CA1165250A - Method and apparatus for testing and using membrane filters in an on site of use housing - Google Patents
Method and apparatus for testing and using membrane filters in an on site of use housingInfo
- Publication number
- CA1165250A CA1165250A CA000387353A CA387353A CA1165250A CA 1165250 A CA1165250 A CA 1165250A CA 000387353 A CA000387353 A CA 000387353A CA 387353 A CA387353 A CA 387353A CA 1165250 A CA1165250 A CA 1165250A
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- indicating means
- outlet
- membrane
- inlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 87
- 238000012360 testing method Methods 0.000 title claims abstract description 84
- 238000000034 method Methods 0.000 title claims abstract description 18
- 230000002950 deficient Effects 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 63
- 238000004891 communication Methods 0.000 claims description 23
- 230000006854 communication Effects 0.000 claims description 23
- 238000013022 venting Methods 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 11
- 238000012544 monitoring process Methods 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000006260 foam Substances 0.000 claims description 5
- 238000010998 test method Methods 0.000 claims description 5
- 238000011016 integrity testing Methods 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 239000000543 intermediate Substances 0.000 claims 2
- 229940090045 cartridge Drugs 0.000 description 31
- 210000004379 membrane Anatomy 0.000 description 31
- 239000011521 glass Substances 0.000 description 26
- 230000005587 bubbling Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000009740 moulding (composite fabrication) Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000011175 product filtration Methods 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/14—Safety devices specially adapted for filtration; Devices for indicating clogging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/10—Testing of membranes or membrane apparatus; Detecting or repairing leaks
- B01D65/102—Detection of leaks in membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
- G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/44—Cartridge types
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Water Supply & Treatment (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
I.S. 16,138 Title: Method And Apparatus For Testing And Using Membrane Filters In An On Site Of Use Housing Inventor: V. Walter Kowalski ABSTRACT
An improved method and apparatus for testing a membrane filter in an on site of use housing and to simultaneously test a plurality of membrane filters in a common housing at the site of use to independently determine if each filter is acceptable for use or is defective.
An improved method and apparatus for testing a membrane filter in an on site of use housing and to simultaneously test a plurality of membrane filters in a common housing at the site of use to independently determine if each filter is acceptable for use or is defective.
Description
METHOD AND APPARATUS FOR TESTING AND USI~G
MEMBRANE FILTERS IN AN ON SITE OF USE ~OUSING
The present invention relates generally to testing membrane type filters and more particularly to a novel method - and apparatus for testing membrane filters in an "on site of use" housing.
The specific construction of the membrane filter mean~ disposed w~thin the "on site of use" housing is not to be construed as a limitation of the present invention.
The filter means may be a suitably supported disc-type membrane or a membrane type filter cartridge. The present invention also contemplates simultaneously testing multiple membrane type filter cartridges and determining which, if any, individual cartridge is not suitable for use, such cartridges being of unique design.
Membranes are being employed in the Piltration of liquids where sterility must be assured and bacterio-logical organisms must be removed. This is normally accom-plished by using membranes in the microporous range such as disclosed in U.S. patent 3~876,738.
r ~ ~ .
l.S. 16,l~
, ~ ~ ~ 5Z 50 Users of membrane filters require validation of the filters before, during and after product filtration, and it is necessary to prevent any contamination from being introduced from outside sources. This 5 dictates the importance of on site of usP testing without creating outside sources of contamination.
In methods according to the prior art it has nor-mally been necessary to use accessory equipment such as graduated cylinders, flasks, pans, hoses, etc., 10 all of which are e~traneous to the fixed on site installation. Various membrane filter tests used up to this time by industry are described in an article entitled "Non-Destructive Tests For Bacterial Re-tentive Filters" by Ben Trasen which was published in 15 the September/October 1979 issue of the Journal of Parental Drug Association, pages 273 t~ 279.
The applicant knows of no prior art method of simultaneously testing multiple mem~rane filter cartridges and individually validating or positively 20 determining which one of the several cartridges is defective in a multi-cartridge housing However, industry has been using multiple membrane cartridges within a single housing and, to avoid unnecessary con-tamination, has been batch testing the cartridges at 25 the point of use in a manner noted above. It should be appreciated that membrane cartridges are costly ` and with the batch test methods presently in use, all 16,138 ,. .
~ ~ ~ 5Z SO
of the cartridges in a single housing are probably discarded when there ma~ be only one which is bad.
Accordingly, one object of the present invention is to provide an improved method and appar-atus for testing membrane filters at the site of use.
Another object of the present invention is to provide a method and appara.tus which requires no extraneous equipment and once the connections to the housing have been made and the housing has been closed, the integrity of the filter unit during test and use is not disturbed unless a defective membrane filter must be replaced.
Still another object of the present inven-tion is to provide a method and apparatus wherein a plurality of membrane filters are simultaneously tested wit~hin a single housing.
And another object of the present invention is to provide a method and apparatus with means for determining whether each of the membrane filters is acceptable for use.
And another object of the present invention is to provide a method and apparatus with permanent inlet and outlet connections for both the test liquid and the liquid to be filtered, and inlet and outlet connections remaining undisturbed when a membrane filter is replaced.
Still another object of the present invention is to provide a novel membrane filter cartridge with its core open at both ends during use of the cartridge.
And still another object of the present invention is to provide a membrane filter cartridge with redundant sealing means at its ends.
According to the above objects, from a broad aspect, the present invention provides an apparatus for integrity testing and using membrane filter means at the site of use, comprising a base and a cover releasably ; connected to said base thereby forming a housing which defines a filter chamber, a membrane filter disposed within said housing and dividing the filter chamber into an inlet area on one side of said membrane filter and an outlet area on the opposite side of said membrane filter, said housing having an inlet in communication with the inlet area of said chamber, an outlet in communication with the outlet area of said chamber and vent means communicating with said inlet area at the upper portion of said chamber, said inlet adapted at particular times to be selectively closed, connected to a source o test fluid during test of said membrane filter and to a source of fluid to be filtered during use of said mem-brane filter~ said outlet adapted at particular times to be ~electively clo3ed, connected to a return l.ine for said test fluid during test and to a delivery line for said filtered fluid during use, said vent means adapted at particular 1~65;250 - 4a -times to be selectively closed and connected to a source of controlled air pressure, and a flow condition indicating means communicating with the outlet area at the upper portion of said chamber, and having valve means for control-ling flow through said indicating means.
According to a still further broad aspect of the present invention there is provided a method of testing membrane type filter car,tridges at the site o use, compris-ing the steps of placing a plurality of cartridges in the chamber of a filter housing at the filtering site with the lower end of the core of each cartridge in communication with the outlet of the housing and the upper end of the core of each cartridge in communication with a different one of a plurality of flow condition indicating means which extend through the top of the housing, with the outlet closed, venting the top of the chamber and opening the inlet to admit test liquid to fill the chamber, closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through all of the cartrldges to the open outlet, venting the indicating means one by one to sequentially fill each of the indicating means while main-taining flow through all of the cartridges until the membrane filter media thereof is thoroughly wet by the test liquid, closing the inlet and connecting chamber to air pressure at about 5 psig to cause all of the test liquid to flow from the chamber through the membrane filter media of all of the - ~b -cartridges while monitoring all of the indicating means to determine that no air bubbles appear therein, increasing the air pressure slowly while monitoring all of the indicating means to determine that no air bubbles appear in quick sequence in any of the indicating means until the air pressure reaches the acceptable diffusional flow rate test pressure range as predetermined in accordance with the membrane filter media of the cartridges being tested, and draining all test liquid from the chamber, the indicating means and the cartridges.
The foregoing and other objects and advantages will appear more fully hereinafter from a consideration of the detailed description which follows, taken together with the accompanying drawing wherein several embodiments of the invention are illustrated by way of example. It is to be expressly understood, however, that the drawings are for illustration purposes only and are not to be construed as defining the limits of the present invention.
FIGURE 1 of the drawings is an elevational view of a multi-cartridge filter with portions thereof brolcen away to better illustrate the present invention.
FIGURE 2 is an elevational view of a filter in accordance with the present invention having a disc type ,~ membrane for the filter media therein.
FIGURE 3 is a sectional view taken on line 3-3 of FIGURE 2.
. .
, ,: ;
I.S. 16,138 ~65250 While only a multi-cartridge housing is shown in FIGURE 1 of the drawings, a showing of a single cartridge and housing would be mere dupli-cation of the illustration provided. For clarity, 5 the novel invention will be described and discussed in connection with multi-cartridges in a single housing.. When applied to a single cartridge in a single cartridge housing, duplication of parts and manifolding for multi-cartridges would not be re-10 quired, as will be further discussed.
It also is to be understood that membranecartridges as used herein is intended to mèan any cartridge type filters having membrane filter media.
To facilitate description, three-way valves are 15 employed to alternatively connect test liquid or liquid to be filtered to the inlet and outlet which may also be closed by such valves. A three way valve is also employed to alternatively close or connect the filter chamber within the housing to atmosphere 20 for venting or to control air pressure as may be required. It is considered to be merely a matter of choice to employ such three way valves or to use separately valved line connections.
; Referring now to the drawings, and more 25 particularly to FIGURE 1, the novel apparatus is pro-vided with a housing comDrisins eubular cover 10 ,; .
.
I.S. 16, 138 ~P65ZSO
having a flange ring ll for releasably connect-ing the cover at its lower end to a base 20 by a series of releasable connector or fastening means 12 (only one being sho~n). The upper end of the 5 cover 10 is closed by a top plate 15 having a plur-ality of openings 16 with sockets or adaptors 17A
for mounting visual flow condition indicating means such as sight glasses or gages 17. Each glass or gage 17, which is provided at its inner end with a lO socket or adaptor 17A, is provided at its outer end with a valve 18 the function of which will be further discussed. It should be noted that the sockets or adaptors provide flow communication be-tween the upper portion of the filter chamber 13 and 15 the indicating means or sight glasses 17.
The housing comprising the cover 10 and ,~ base 20 ~efines a filter chamber 13 which is pro-vided with a port or flow path 19 in communication with the upper portion of the filter chamber 13. The 20 flow path 19 is provided to vent the filter chamber 13 to atmosphere and is adapted to be selectively closed and connected to a source 37 of controlled air pressure having a gage 38 for instantaneously in-dicating pressure of the controlled air, preferably by 25 provision of a three way valve 35 having a vent connection or port 36, as shown.
. , ' . ' ' ,., ; ' " ' .
I.S. 16,138 , ~65250 The base 20 is formed by an inner plate 21 and an outer plate 22 joined together in face - to face relationship by a series of fasteners 23 (only one shown). The plates 21 and 22 are pro-5 vided with axially aligned central openings defining an inlet 24 for the filter chamber 13. The outer plate 22 is further provided with a recess 26 form-ing a manifold which provides conmlunication between an outlet 25 in the outer plate 22 and a plurality 10 of soclcets or socket openings 27 through the inner plate 21. The openings 27 are equal in number and are axially aligned with the openings 16 in the upper plate 15 or with the sockets or adaptors 17A for the sight glasses or indicating means 17. The inlet 24 15 is adapted to selectively receive test liquid and liquid to be filtered, and al80 be closed or connected to drain the chamber 13; while the outlet 25 is adap-ted to be selectively closed, connected to discharge test liquid and to discharge filtered liquid. This 20 is preferably accomplished by providing three way valve 40 to close the inlet 24 in one position or to connect the inlet to a source 41 of test liquid or a source 42 of liquid to be filtered Similarly, a three way valve 45 is provided to close outlet 25 or to 25 connect the outlet to a discharge line 46 for test liquid or to a discharge line 47 for filtered li~uid.
', ' , ., ~ , , ~ , , I.S. 16,1~8 .
1~.65250 .
. A suitable valved drain or drain valve 28 for the filter chamber 13 is provided adjacent the valve 40, as show~,or valve 40 may be made to provide a drain position. Alternatively, filter chamber 13 can be 5 fully drained by removing pressure from inlet line 41 for test liquid which is connected to inlet 24 by the valve 40, and, opening valve 35 to vent.
A plurality of membrane cartridges 30 are provided in the filter chamber 13 each having a unique 10 upper end cap or cap assembly 31 sealing the top end of the membrane and extending or being plugged into the socket 17A of a sight glass 17. Each end cap 31 J is provided with redundant sacket seal means in the form of a pair of axially spaced 0-rings 33 to prevent 15 leakage through the connection f~om the chamber 13.
Similarly, each cartridge 30 is provided with a lower end cap or cap assembly 32 sealing the bottom end of the cartridge membrane and extending into or being plugged into an appropriate socket opening 27 axially 20 aligned with the socket 17A of a sight glass or in-dicating means 17 receiving the upper end cap 31.
The lower ent cap 32 is also provided with redundant sealing in the form of a pair of axially spaced 0-rings 34. It should be particularly noted that the core of 25 each cartridge is open at both ends, and communicates at its upper end through end cap 31 with a sight glass -' ' ' I.S, 16,13%
1~65Z50 or indicating means 17 and at its lower end through end cap 32, the appropriate socket 26 with the mani-fold 26 and outlet 25. Adding to the unique con-struction of the cartridge 30, the upper end cap 31 is provided with a tapered or conical inner surface 31A which connects a flow path portion of larger dia-meter receiving the upper end of the cartridge core and assists or permits air bubbles to rise unimpeded from the cartridge core through a flow path portion of smaller diameter into the indicatin~ means or sight glass 17.
In an arrangement having o,nly a single cart-ridge 30 in a single cartridge housing, only one opening 16 for a single adaptor 17A and sight glass 17 would be required. The manifold 26 would be elimin-ated and a single socket opening 27 would be aligned with the outlet 25 in a manner similar to the inlet 24, In effect, it would be preferable to eliminate the inner plate 21 from the base 20 and the outlet 25 would be axially aligned with the single opening 16, In this instance, the outlet 25 would be a socket and receive the lower end cap 32 of the single cart-ridge 30.
It should be noted that the vent 19 and the inlet 24 are in flow communication with the cham-ber 13 on the inlet side of the membranes of the I.S, 16,138 ~65Z50 membranes of the cartridges 30 which is considered as being the inlet chamber area. The cores of the cartridges 30 on the opposite side of the membranes, with or without the manifold 16, are considered as being the outlet chamber area in flow communication - with the sight glasses or indicating means 17 and the outlet 25.
In the absence of liquid in the apparatus and with valves 18, 28, 35, 40 and 45 all closed, fasteners 12 can be rotated to release the flange 11 and cover 10 can be removed from the base 20. An appropriate number of cartridges 30 are put into the cover 10 with the upper end caps 31 each being inserted or plugged into the inner end or socket member 17A of a different one of the sight glasses or gages 17 while the lower end caps 32 are inserted or plugged into the appropriate axially aligned sockets or socket openings 27 in the base 20. The cover 10 i5 then reclamped to the base 20 by fasteners 12 and the apparatus is prepared for testing the mem-brane cartridges 30.
Initially, valve 35 is opened to vent the inlet area of chamber 13 through lines 19 and 36, and valve 40 is operated to gradually connect line 41 from a source of test liquid or wetting fluid to the inlet 24 for filling the inlet area of the chamber 13.
I.S. 16,138 ~ ~65250 When the test liquid starts to escape from the vent 36, the valve 35 is closed and valve 45 is opened tO
connect the outlet 25 to the test liquid return line 46 providing a controlled circulating flow of test 5 liquid through the cartridges 30 to wet the membranes thereof and fill the outlet area of the filter cham-ber 13 with test liquid. One by one the valves 18 are opened unless they are self venting, to fill the sight glasses or indicating means 17 with test liquid lO and are closed as each of the sight glasses are filled. The flow rate of the test liquid can be controlled by manipulation of valves 40 and 45 but normally the test liquid circulating system would be provided with valves (not shown) particularly for this 15 purpose. At this time, the filter chamber 13, cart-ridges 30 and indicating means or sight glasses 17 are all filled with test liquid.
Circulating flow of test liquid through the cartridges 30 is maintained for a nominal period of 20 time to assure that the membranes or membrane filter media of the cartridges 30 are sufficiently wet. The inlet 24 is now closed by the valve 40 and a nominal pressure of about 5 psig is provided to the inlet area of the chamber 13 by connecting line 19 to line 37 by 25 valve 35; line 37 being connected to a compressed air or gas source as previously stated. The nominal I.S, 16,138 1~L65Z50 pressure will cause continued flow of test liquid through the cartridges 30 from the inlet area to the outlet area until all but a thin layer of liquid remains at the bottom of the inlet area of the chamber 13.
If during the period nominal pressure is being provided to chamber 13 by monitoring the in-dicating means it is noted that air bubbles appear in one of the indicating means or sight glasses 17 causing the liquid level in the indicating means sight glasses to drop which is an indication of a ,defective cartridge 30, the test either can ~ontinue by appropriate manipulation of valve 18 of that in-,, dicating means or sight glass and the outlet valve45 to control flow and maintain a liquid level inthe defective cartridge slght glass, or the test can be terminated. The defective cartridge 30 would then be replaced and a retest performed.
When essentially all flow of test liquid ' 20 through outlet line 46 has stopped, valve 45 is closed, all valves 18 are opened and the air pressure to fil-ter chamber 13 from the source 37 of controlled air is gradually increased to the diffusional flow rate test pressure when air passes through the membranes 25 and intermittently bubbles into the sight glasses 17 escaping through the open valves 18. The intermittent escape of air bubbles should be essentially the same I.S. 1~,138 lP65Z50 in all of the sight glasses or indicating means 17.
Excessive bubbling in any of the sight glasses 17 would indicate a defective cartridge 30 which is in communication with the sight glass exhibiting excessive bubbling.
To determine the diffusional flow rate, valves 18 are closed and valve 45 is opened connect-ing outlet 25 to line 46. Intermittent air bubbling into the sight glasses 17 will cause the liquid levels 10 therein to drop. This measured drop is timed to cal-culate the diffusional flow rate. If the calculated diffusional flo~7 rate is less than the maximum allow-able diffusional flow rate, the cartridge is acceptable.
If it is desired to determine the foam all-15 over point of a membrane cartridge 30, air pressure is gradùally increased until air bubbles replace the test liquid from the indicatin~ means or sight glasses 17 almost instantaneously, and the pressure of gage 38 will provide the foam all-over point. The air pres-20 sure should be maintained until all test liquid is ex-pelled from the outlet area of the chamber 13 on down-stream side of the membrane media of the cartridges 30.
After tests are completed and all cartridges 30 are acceptable for use, there will be a thin layer 25 of test liquid or wetting fluid in the bottom of the inlet area of the chamber 13 of a depth approximately equal to the height of the bottom end caps 32 of the I.S. 16,138 1~L65250 . -14-cartridges 30. Since all of the test liquid will have been drained from the sight glasses 17 and cartridges 30, with valves 18 and 45 closed, the valve 35 is opened to vent the inlet area o~ the 5 chamber 13 and valve 28 is opened to drain all the test liquid remaining at the bottom of the inlet area of chamber 13 through the inlet 24. After draining is complete, the valves 35 and 28 are closed and filtering can commence without further 10 delay by connecting inlet line 42 for liquid to be filtered to the inlet 24 by valve 40 and discharge line 47 for filtered liquid to outlet 25 by valve 45. During filtration, appropriate manipulation of the inlet valve 40 and the outlet valve 45 can con-15 trol the flow rate or the system can be providedwith automatic flow control means.
It should be readily understood that when the filter unit has but a single filte. cartridge 30, there will be only one visible indicating means 17 20 with its vent valve 18. Testing of such a unit will be as previously described with only the single in-dicating means 17 being monitored and controlled by its valve 18.
Referring now to FIGURES 2 and 3, a modified 25 housing is co~prised of a cover 110 and a base 120 ., corresponding to the cover 10 and base 20, respective-I.S. 16,138 ~5~50 ly, of FIGURE 1. The cover 110 and base 120 are releasably connected together by fastening ~eans 112, and are formed to define a filter chamber 113 corresponding to chamber 13. In place of the mem-brane filter cartridges 30 of FIGURE 1, a disc-type membrane filter 130 with a-suitable porous or per-forated backing plate or sheet 131 is disposed in and divides the chamber 113 into inlet and outlet areas. The peripheries of the membrane 130 and backing plate or sheet 131 are retained or clamped between the cover 110 and base 120, and are provided thereat, as shown, with O-ring seals 133 and 134.
An inlet 124, in communication with the inlet area of the filter chamber 130, corresponds to the lnlet 24 and is adapted for similar flow control by the valve 40 while an outlet 125 in communication with the outlet area of the filter chamber 130, corres-ponds to the outlet 25 and is adapted for similar flow control by the valve 45. The cover 110 is provided 20 with a vent port 119, corresponding to the flow path 19, in communication withthe inlet area at the upper portion of the filter chamber 130 and is adapted for selective flow control by the valve 35. The ~odified housing also is provided ~7ith an opening or flow path 25 116 corresponding to one of the openings 16, and a I.S. 16,138 ~65Z50 socket or adaptor 117A corresponding to the socket 17A. The socket 117A mounts a sight glass or visible indicating means 17, and with openings 116, provides communication for the visible indicating means 17 5 with the outlet area at the upper portion of the filter chamber 130.
The base 120 is preferably provided with a plurality of ribs 121 which extend into the outlet area of filter chamber 113 to engage and support the 10 backing plate or sheet 131 against deflection due to pressure differentials across the filter membrane 130.
This modified filter will be tested and used in the same manner as previousl7 described re-15 lative to the filter of FIGURE l when only a singlefilter cartridge 30 is tested and used.
Although several embodiments of the in-vention have been illustrated and described in detail, it is to be expressly understood that the invention 20 is not limited thereto. Various changes may be made in the design and arrangement of the parts without departing from the spirit and scope of the invention as the same will now be understood by those skilled' in the art.
MEMBRANE FILTERS IN AN ON SITE OF USE ~OUSING
The present invention relates generally to testing membrane type filters and more particularly to a novel method - and apparatus for testing membrane filters in an "on site of use" housing.
The specific construction of the membrane filter mean~ disposed w~thin the "on site of use" housing is not to be construed as a limitation of the present invention.
The filter means may be a suitably supported disc-type membrane or a membrane type filter cartridge. The present invention also contemplates simultaneously testing multiple membrane type filter cartridges and determining which, if any, individual cartridge is not suitable for use, such cartridges being of unique design.
Membranes are being employed in the Piltration of liquids where sterility must be assured and bacterio-logical organisms must be removed. This is normally accom-plished by using membranes in the microporous range such as disclosed in U.S. patent 3~876,738.
r ~ ~ .
l.S. 16,l~
, ~ ~ ~ 5Z 50 Users of membrane filters require validation of the filters before, during and after product filtration, and it is necessary to prevent any contamination from being introduced from outside sources. This 5 dictates the importance of on site of usP testing without creating outside sources of contamination.
In methods according to the prior art it has nor-mally been necessary to use accessory equipment such as graduated cylinders, flasks, pans, hoses, etc., 10 all of which are e~traneous to the fixed on site installation. Various membrane filter tests used up to this time by industry are described in an article entitled "Non-Destructive Tests For Bacterial Re-tentive Filters" by Ben Trasen which was published in 15 the September/October 1979 issue of the Journal of Parental Drug Association, pages 273 t~ 279.
The applicant knows of no prior art method of simultaneously testing multiple mem~rane filter cartridges and individually validating or positively 20 determining which one of the several cartridges is defective in a multi-cartridge housing However, industry has been using multiple membrane cartridges within a single housing and, to avoid unnecessary con-tamination, has been batch testing the cartridges at 25 the point of use in a manner noted above. It should be appreciated that membrane cartridges are costly ` and with the batch test methods presently in use, all 16,138 ,. .
~ ~ ~ 5Z SO
of the cartridges in a single housing are probably discarded when there ma~ be only one which is bad.
Accordingly, one object of the present invention is to provide an improved method and appar-atus for testing membrane filters at the site of use.
Another object of the present invention is to provide a method and appara.tus which requires no extraneous equipment and once the connections to the housing have been made and the housing has been closed, the integrity of the filter unit during test and use is not disturbed unless a defective membrane filter must be replaced.
Still another object of the present inven-tion is to provide a method and apparatus wherein a plurality of membrane filters are simultaneously tested wit~hin a single housing.
And another object of the present invention is to provide a method and apparatus with means for determining whether each of the membrane filters is acceptable for use.
And another object of the present invention is to provide a method and apparatus with permanent inlet and outlet connections for both the test liquid and the liquid to be filtered, and inlet and outlet connections remaining undisturbed when a membrane filter is replaced.
Still another object of the present invention is to provide a novel membrane filter cartridge with its core open at both ends during use of the cartridge.
And still another object of the present invention is to provide a membrane filter cartridge with redundant sealing means at its ends.
According to the above objects, from a broad aspect, the present invention provides an apparatus for integrity testing and using membrane filter means at the site of use, comprising a base and a cover releasably ; connected to said base thereby forming a housing which defines a filter chamber, a membrane filter disposed within said housing and dividing the filter chamber into an inlet area on one side of said membrane filter and an outlet area on the opposite side of said membrane filter, said housing having an inlet in communication with the inlet area of said chamber, an outlet in communication with the outlet area of said chamber and vent means communicating with said inlet area at the upper portion of said chamber, said inlet adapted at particular times to be selectively closed, connected to a source o test fluid during test of said membrane filter and to a source of fluid to be filtered during use of said mem-brane filter~ said outlet adapted at particular times to be ~electively clo3ed, connected to a return l.ine for said test fluid during test and to a delivery line for said filtered fluid during use, said vent means adapted at particular 1~65;250 - 4a -times to be selectively closed and connected to a source of controlled air pressure, and a flow condition indicating means communicating with the outlet area at the upper portion of said chamber, and having valve means for control-ling flow through said indicating means.
According to a still further broad aspect of the present invention there is provided a method of testing membrane type filter car,tridges at the site o use, compris-ing the steps of placing a plurality of cartridges in the chamber of a filter housing at the filtering site with the lower end of the core of each cartridge in communication with the outlet of the housing and the upper end of the core of each cartridge in communication with a different one of a plurality of flow condition indicating means which extend through the top of the housing, with the outlet closed, venting the top of the chamber and opening the inlet to admit test liquid to fill the chamber, closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through all of the cartrldges to the open outlet, venting the indicating means one by one to sequentially fill each of the indicating means while main-taining flow through all of the cartridges until the membrane filter media thereof is thoroughly wet by the test liquid, closing the inlet and connecting chamber to air pressure at about 5 psig to cause all of the test liquid to flow from the chamber through the membrane filter media of all of the - ~b -cartridges while monitoring all of the indicating means to determine that no air bubbles appear therein, increasing the air pressure slowly while monitoring all of the indicating means to determine that no air bubbles appear in quick sequence in any of the indicating means until the air pressure reaches the acceptable diffusional flow rate test pressure range as predetermined in accordance with the membrane filter media of the cartridges being tested, and draining all test liquid from the chamber, the indicating means and the cartridges.
The foregoing and other objects and advantages will appear more fully hereinafter from a consideration of the detailed description which follows, taken together with the accompanying drawing wherein several embodiments of the invention are illustrated by way of example. It is to be expressly understood, however, that the drawings are for illustration purposes only and are not to be construed as defining the limits of the present invention.
FIGURE 1 of the drawings is an elevational view of a multi-cartridge filter with portions thereof brolcen away to better illustrate the present invention.
FIGURE 2 is an elevational view of a filter in accordance with the present invention having a disc type ,~ membrane for the filter media therein.
FIGURE 3 is a sectional view taken on line 3-3 of FIGURE 2.
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I.S. 16,138 ~65250 While only a multi-cartridge housing is shown in FIGURE 1 of the drawings, a showing of a single cartridge and housing would be mere dupli-cation of the illustration provided. For clarity, 5 the novel invention will be described and discussed in connection with multi-cartridges in a single housing.. When applied to a single cartridge in a single cartridge housing, duplication of parts and manifolding for multi-cartridges would not be re-10 quired, as will be further discussed.
It also is to be understood that membranecartridges as used herein is intended to mèan any cartridge type filters having membrane filter media.
To facilitate description, three-way valves are 15 employed to alternatively connect test liquid or liquid to be filtered to the inlet and outlet which may also be closed by such valves. A three way valve is also employed to alternatively close or connect the filter chamber within the housing to atmosphere 20 for venting or to control air pressure as may be required. It is considered to be merely a matter of choice to employ such three way valves or to use separately valved line connections.
; Referring now to the drawings, and more 25 particularly to FIGURE 1, the novel apparatus is pro-vided with a housing comDrisins eubular cover 10 ,; .
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I.S. 16, 138 ~P65ZSO
having a flange ring ll for releasably connect-ing the cover at its lower end to a base 20 by a series of releasable connector or fastening means 12 (only one being sho~n). The upper end of the 5 cover 10 is closed by a top plate 15 having a plur-ality of openings 16 with sockets or adaptors 17A
for mounting visual flow condition indicating means such as sight glasses or gages 17. Each glass or gage 17, which is provided at its inner end with a lO socket or adaptor 17A, is provided at its outer end with a valve 18 the function of which will be further discussed. It should be noted that the sockets or adaptors provide flow communication be-tween the upper portion of the filter chamber 13 and 15 the indicating means or sight glasses 17.
The housing comprising the cover 10 and ,~ base 20 ~efines a filter chamber 13 which is pro-vided with a port or flow path 19 in communication with the upper portion of the filter chamber 13. The 20 flow path 19 is provided to vent the filter chamber 13 to atmosphere and is adapted to be selectively closed and connected to a source 37 of controlled air pressure having a gage 38 for instantaneously in-dicating pressure of the controlled air, preferably by 25 provision of a three way valve 35 having a vent connection or port 36, as shown.
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I.S. 16,138 , ~65250 The base 20 is formed by an inner plate 21 and an outer plate 22 joined together in face - to face relationship by a series of fasteners 23 (only one shown). The plates 21 and 22 are pro-5 vided with axially aligned central openings defining an inlet 24 for the filter chamber 13. The outer plate 22 is further provided with a recess 26 form-ing a manifold which provides conmlunication between an outlet 25 in the outer plate 22 and a plurality 10 of soclcets or socket openings 27 through the inner plate 21. The openings 27 are equal in number and are axially aligned with the openings 16 in the upper plate 15 or with the sockets or adaptors 17A for the sight glasses or indicating means 17. The inlet 24 15 is adapted to selectively receive test liquid and liquid to be filtered, and al80 be closed or connected to drain the chamber 13; while the outlet 25 is adap-ted to be selectively closed, connected to discharge test liquid and to discharge filtered liquid. This 20 is preferably accomplished by providing three way valve 40 to close the inlet 24 in one position or to connect the inlet to a source 41 of test liquid or a source 42 of liquid to be filtered Similarly, a three way valve 45 is provided to close outlet 25 or to 25 connect the outlet to a discharge line 46 for test liquid or to a discharge line 47 for filtered li~uid.
', ' , ., ~ , , ~ , , I.S. 16,1~8 .
1~.65250 .
. A suitable valved drain or drain valve 28 for the filter chamber 13 is provided adjacent the valve 40, as show~,or valve 40 may be made to provide a drain position. Alternatively, filter chamber 13 can be 5 fully drained by removing pressure from inlet line 41 for test liquid which is connected to inlet 24 by the valve 40, and, opening valve 35 to vent.
A plurality of membrane cartridges 30 are provided in the filter chamber 13 each having a unique 10 upper end cap or cap assembly 31 sealing the top end of the membrane and extending or being plugged into the socket 17A of a sight glass 17. Each end cap 31 J is provided with redundant sacket seal means in the form of a pair of axially spaced 0-rings 33 to prevent 15 leakage through the connection f~om the chamber 13.
Similarly, each cartridge 30 is provided with a lower end cap or cap assembly 32 sealing the bottom end of the cartridge membrane and extending into or being plugged into an appropriate socket opening 27 axially 20 aligned with the socket 17A of a sight glass or in-dicating means 17 receiving the upper end cap 31.
The lower ent cap 32 is also provided with redundant sealing in the form of a pair of axially spaced 0-rings 34. It should be particularly noted that the core of 25 each cartridge is open at both ends, and communicates at its upper end through end cap 31 with a sight glass -' ' ' I.S, 16,13%
1~65Z50 or indicating means 17 and at its lower end through end cap 32, the appropriate socket 26 with the mani-fold 26 and outlet 25. Adding to the unique con-struction of the cartridge 30, the upper end cap 31 is provided with a tapered or conical inner surface 31A which connects a flow path portion of larger dia-meter receiving the upper end of the cartridge core and assists or permits air bubbles to rise unimpeded from the cartridge core through a flow path portion of smaller diameter into the indicatin~ means or sight glass 17.
In an arrangement having o,nly a single cart-ridge 30 in a single cartridge housing, only one opening 16 for a single adaptor 17A and sight glass 17 would be required. The manifold 26 would be elimin-ated and a single socket opening 27 would be aligned with the outlet 25 in a manner similar to the inlet 24, In effect, it would be preferable to eliminate the inner plate 21 from the base 20 and the outlet 25 would be axially aligned with the single opening 16, In this instance, the outlet 25 would be a socket and receive the lower end cap 32 of the single cart-ridge 30.
It should be noted that the vent 19 and the inlet 24 are in flow communication with the cham-ber 13 on the inlet side of the membranes of the I.S, 16,138 ~65Z50 membranes of the cartridges 30 which is considered as being the inlet chamber area. The cores of the cartridges 30 on the opposite side of the membranes, with or without the manifold 16, are considered as being the outlet chamber area in flow communication - with the sight glasses or indicating means 17 and the outlet 25.
In the absence of liquid in the apparatus and with valves 18, 28, 35, 40 and 45 all closed, fasteners 12 can be rotated to release the flange 11 and cover 10 can be removed from the base 20. An appropriate number of cartridges 30 are put into the cover 10 with the upper end caps 31 each being inserted or plugged into the inner end or socket member 17A of a different one of the sight glasses or gages 17 while the lower end caps 32 are inserted or plugged into the appropriate axially aligned sockets or socket openings 27 in the base 20. The cover 10 i5 then reclamped to the base 20 by fasteners 12 and the apparatus is prepared for testing the mem-brane cartridges 30.
Initially, valve 35 is opened to vent the inlet area of chamber 13 through lines 19 and 36, and valve 40 is operated to gradually connect line 41 from a source of test liquid or wetting fluid to the inlet 24 for filling the inlet area of the chamber 13.
I.S. 16,138 ~ ~65250 When the test liquid starts to escape from the vent 36, the valve 35 is closed and valve 45 is opened tO
connect the outlet 25 to the test liquid return line 46 providing a controlled circulating flow of test 5 liquid through the cartridges 30 to wet the membranes thereof and fill the outlet area of the filter cham-ber 13 with test liquid. One by one the valves 18 are opened unless they are self venting, to fill the sight glasses or indicating means 17 with test liquid lO and are closed as each of the sight glasses are filled. The flow rate of the test liquid can be controlled by manipulation of valves 40 and 45 but normally the test liquid circulating system would be provided with valves (not shown) particularly for this 15 purpose. At this time, the filter chamber 13, cart-ridges 30 and indicating means or sight glasses 17 are all filled with test liquid.
Circulating flow of test liquid through the cartridges 30 is maintained for a nominal period of 20 time to assure that the membranes or membrane filter media of the cartridges 30 are sufficiently wet. The inlet 24 is now closed by the valve 40 and a nominal pressure of about 5 psig is provided to the inlet area of the chamber 13 by connecting line 19 to line 37 by 25 valve 35; line 37 being connected to a compressed air or gas source as previously stated. The nominal I.S, 16,138 1~L65Z50 pressure will cause continued flow of test liquid through the cartridges 30 from the inlet area to the outlet area until all but a thin layer of liquid remains at the bottom of the inlet area of the chamber 13.
If during the period nominal pressure is being provided to chamber 13 by monitoring the in-dicating means it is noted that air bubbles appear in one of the indicating means or sight glasses 17 causing the liquid level in the indicating means sight glasses to drop which is an indication of a ,defective cartridge 30, the test either can ~ontinue by appropriate manipulation of valve 18 of that in-,, dicating means or sight glass and the outlet valve45 to control flow and maintain a liquid level inthe defective cartridge slght glass, or the test can be terminated. The defective cartridge 30 would then be replaced and a retest performed.
When essentially all flow of test liquid ' 20 through outlet line 46 has stopped, valve 45 is closed, all valves 18 are opened and the air pressure to fil-ter chamber 13 from the source 37 of controlled air is gradually increased to the diffusional flow rate test pressure when air passes through the membranes 25 and intermittently bubbles into the sight glasses 17 escaping through the open valves 18. The intermittent escape of air bubbles should be essentially the same I.S. 1~,138 lP65Z50 in all of the sight glasses or indicating means 17.
Excessive bubbling in any of the sight glasses 17 would indicate a defective cartridge 30 which is in communication with the sight glass exhibiting excessive bubbling.
To determine the diffusional flow rate, valves 18 are closed and valve 45 is opened connect-ing outlet 25 to line 46. Intermittent air bubbling into the sight glasses 17 will cause the liquid levels 10 therein to drop. This measured drop is timed to cal-culate the diffusional flow rate. If the calculated diffusional flo~7 rate is less than the maximum allow-able diffusional flow rate, the cartridge is acceptable.
If it is desired to determine the foam all-15 over point of a membrane cartridge 30, air pressure is gradùally increased until air bubbles replace the test liquid from the indicatin~ means or sight glasses 17 almost instantaneously, and the pressure of gage 38 will provide the foam all-over point. The air pres-20 sure should be maintained until all test liquid is ex-pelled from the outlet area of the chamber 13 on down-stream side of the membrane media of the cartridges 30.
After tests are completed and all cartridges 30 are acceptable for use, there will be a thin layer 25 of test liquid or wetting fluid in the bottom of the inlet area of the chamber 13 of a depth approximately equal to the height of the bottom end caps 32 of the I.S. 16,138 1~L65250 . -14-cartridges 30. Since all of the test liquid will have been drained from the sight glasses 17 and cartridges 30, with valves 18 and 45 closed, the valve 35 is opened to vent the inlet area o~ the 5 chamber 13 and valve 28 is opened to drain all the test liquid remaining at the bottom of the inlet area of chamber 13 through the inlet 24. After draining is complete, the valves 35 and 28 are closed and filtering can commence without further 10 delay by connecting inlet line 42 for liquid to be filtered to the inlet 24 by valve 40 and discharge line 47 for filtered liquid to outlet 25 by valve 45. During filtration, appropriate manipulation of the inlet valve 40 and the outlet valve 45 can con-15 trol the flow rate or the system can be providedwith automatic flow control means.
It should be readily understood that when the filter unit has but a single filte. cartridge 30, there will be only one visible indicating means 17 20 with its vent valve 18. Testing of such a unit will be as previously described with only the single in-dicating means 17 being monitored and controlled by its valve 18.
Referring now to FIGURES 2 and 3, a modified 25 housing is co~prised of a cover 110 and a base 120 ., corresponding to the cover 10 and base 20, respective-I.S. 16,138 ~5~50 ly, of FIGURE 1. The cover 110 and base 120 are releasably connected together by fastening ~eans 112, and are formed to define a filter chamber 113 corresponding to chamber 13. In place of the mem-brane filter cartridges 30 of FIGURE 1, a disc-type membrane filter 130 with a-suitable porous or per-forated backing plate or sheet 131 is disposed in and divides the chamber 113 into inlet and outlet areas. The peripheries of the membrane 130 and backing plate or sheet 131 are retained or clamped between the cover 110 and base 120, and are provided thereat, as shown, with O-ring seals 133 and 134.
An inlet 124, in communication with the inlet area of the filter chamber 130, corresponds to the lnlet 24 and is adapted for similar flow control by the valve 40 while an outlet 125 in communication with the outlet area of the filter chamber 130, corres-ponds to the outlet 25 and is adapted for similar flow control by the valve 45. The cover 110 is provided 20 with a vent port 119, corresponding to the flow path 19, in communication withthe inlet area at the upper portion of the filter chamber 130 and is adapted for selective flow control by the valve 35. The ~odified housing also is provided ~7ith an opening or flow path 25 116 corresponding to one of the openings 16, and a I.S. 16,138 ~65Z50 socket or adaptor 117A corresponding to the socket 17A. The socket 117A mounts a sight glass or visible indicating means 17, and with openings 116, provides communication for the visible indicating means 17 5 with the outlet area at the upper portion of the filter chamber 130.
The base 120 is preferably provided with a plurality of ribs 121 which extend into the outlet area of filter chamber 113 to engage and support the 10 backing plate or sheet 131 against deflection due to pressure differentials across the filter membrane 130.
This modified filter will be tested and used in the same manner as previousl7 described re-15 lative to the filter of FIGURE l when only a singlefilter cartridge 30 is tested and used.
Although several embodiments of the in-vention have been illustrated and described in detail, it is to be expressly understood that the invention 20 is not limited thereto. Various changes may be made in the design and arrangement of the parts without departing from the spirit and scope of the invention as the same will now be understood by those skilled' in the art.
Claims (22)
1. Apparatus for integrity testing and using membrane filter means at the site of use, comprising:
a base and a cover releasably connected to said base thereby forming a housing which defines a filter chamber a membrane filter disposed within said housing and dividing the filter chamber into an inlet area on one side of said membrane filter and an outlet area on the opposite side of said membrane filter;
said housing having an inlet in communication with the inlet area of said chamber, an outlet in communication with the outlet area of said chamber and vent means communi-cating with said inlet area at the upper portion of said chamber;
said inlet adapted at particular times to be selectively closed, connected to a source of test fluid during test of said membrane filter and to a source of fluid to be filtered during use of said membrane filter;
said outlet adapted at particular times to be selectively closed, connected to a return line for said test fluid during test and to a delivery line for said filtered fluid during use;
said vent means adapted at particular times to be selectively closed and connected to a source of controlled air pressure; and a flow condition indicating means communicating with the outlet area at the upper portion of said chamber, and having valve means for controlling flow through said indicating means.
a base and a cover releasably connected to said base thereby forming a housing which defines a filter chamber a membrane filter disposed within said housing and dividing the filter chamber into an inlet area on one side of said membrane filter and an outlet area on the opposite side of said membrane filter;
said housing having an inlet in communication with the inlet area of said chamber, an outlet in communication with the outlet area of said chamber and vent means communi-cating with said inlet area at the upper portion of said chamber;
said inlet adapted at particular times to be selectively closed, connected to a source of test fluid during test of said membrane filter and to a source of fluid to be filtered during use of said membrane filter;
said outlet adapted at particular times to be selectively closed, connected to a return line for said test fluid during test and to a delivery line for said filtered fluid during use;
said vent means adapted at particular times to be selectively closed and connected to a source of controlled air pressure; and a flow condition indicating means communicating with the outlet area at the upper portion of said chamber, and having valve means for controlling flow through said indicating means.
2. The apparatus in accordance with claim 1 and the periphery of said membrane filter extending outwardly of said chamber and being retained between said cover and said base.
3. The apparatus in accordance with claim 2, and said membrane filter comprising:
a disc type filter membrane; and a backing plate supporting said membrane and capable of permitting flow of fluid therethrough.
a disc type filter membrane; and a backing plate supporting said membrane and capable of permitting flow of fluid therethrough.
4. The apparatus in accordance with claim 3, and a first O-ring seal disposed between said base and the periphery of said backing plate; and a second O-ring seal disposed between said cover and the periphery of said membrane.
5. The apparatus in accordance with claim 4, and said cover provided with a plurality of ribs extending into the outlet area of said chamber and engaging said backing plate thereby preventing deflection of said membrane filter due to pressure differential across said filter membrane.
6. The apparatus in accordance with claim 1, and said membrane filter comprising a filter cartridge having membrane filter media sealed at its upper and lower ends, an and a core through the filter media;
said cartridge being removably disposed in the inlet area of said chamber; and said core defining the outlet area of said chamber and having an upper end connected to communicate with said flow condition indicating means and a lower end connected to communicate with said outlet.
said cartridge being removably disposed in the inlet area of said chamber; and said core defining the outlet area of said chamber and having an upper end connected to communicate with said flow condition indicating means and a lower end connected to communicate with said outlet.
7 . The apparatus in accordance with claim 6, and said indicating means and said outlet each providing a socket axially aligned with the socket provided by the other;
and said cartridge having a pair of end caps sealing the ends of said filter media and being inserted into said axially aligned sockets thereby providing communication between the outlet area of said chamber and said indicating means at the upper end of said core and said outlet at the lower end of said core.
and said cartridge having a pair of end caps sealing the ends of said filter media and being inserted into said axially aligned sockets thereby providing communication between the outlet area of said chamber and said indicating means at the upper end of said core and said outlet at the lower end of said core.
8. The apparatus in accordance with claim 7, and an axially spaced pair of O-ring seals engaging each of said end caps and said socket into which said end cap is inserted.
9. The apparatus in accordance with claim 8, and said end cap at the upper end of said cartridge defining an axial flow path therethrough with a portion of larger diameter communicating with said core and a portion of smaller diameter communicating with said indicating means;
and said axial flow path having a tapered interme-diate portion flow connecting said portions of larger and smaller diameters to permit air bubbles to rise unimpeded from said core into said indicating means.
and said axial flow path having a tapered interme-diate portion flow connecting said portions of larger and smaller diameters to permit air bubbles to rise unimpeded from said core into said indicating means.
10. The apparatus in accordance with claim 1, and a plurality of said indicating means each communicating with the outlet area at the upper portion of said chambers, said membrane filter comprising a plurality of filter cartridges each having membrane filter media sealed at its upper and lower ends, and a core through the filter media;
said cartridges being removably disposed in the inlet area of said chamber and the cores of said cartridges defining the outlet area of said chamber and each of said cores having an upper end connected to communicate with a different one of said indicating means and a lower end connected to communicate with the outlet.
said cartridges being removably disposed in the inlet area of said chamber and the cores of said cartridges defining the outlet area of said chamber and each of said cores having an upper end connected to communicate with a different one of said indicating means and a lower end connected to communicate with the outlet.
11. The apparatus in accordance with claim 10, and a plurality of pairs of axially aligned sockets in communication with said chamber;
each of said indicating means providing one of said sockets of a different one of said pairs and the housing providing the other sockets of said pairs which communicate with each other and said outlet;
said cartridges each having a pair of end caps sealing the ends of said filter media and being inserted into a different one of said pairs of axially aligned sockets thereby providing communication between the outlet area of said chamber and said indicating means at the upper ends of said cores and said outlet at the lower ends of said cores.
each of said indicating means providing one of said sockets of a different one of said pairs and the housing providing the other sockets of said pairs which communicate with each other and said outlet;
said cartridges each having a pair of end caps sealing the ends of said filter media and being inserted into a different one of said pairs of axially aligned sockets thereby providing communication between the outlet area of said chamber and said indicating means at the upper ends of said cores and said outlet at the lower ends of said cores.
12. The apparatus in accordance with claim 11, and said end cap at the upper end of each of said cartridges defining an axial flow path therethrough with a portion of larger diameter communicating with the core of said cartridge and a portion of smaller diameter at the end of the cap communicating with one of said indicating means; and said axial flow path having an intermediate portion with a tapered wall connecting the portions with larger and smaller diameters together to permit air bubbles to rise unimpeded from said core into said indicating means.
13. The apparatus in accordance with claim 12, and a different axially spaced pair of O-ring seals engaging each of said end caps and said socket into which said end cap is inserted.
14. A method of testing membrane type filter cartridges at the site of use, comprising the steps of:
placing a plurality of cartridges in the chamber of a filter housing at the filtering site with the lower end of the core of each cartridge in communication with the outlet of the housing and the upper end of the core of each cartridge in communication with a different one of a plurality of flow condition indicating means which extend through the top of the housing;
with the outlet closed, venting the top of the chamber and opening the inlet to admit test liquid to fill the chamber;
closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through all of the cartridges to the open outlet;
venting the indicating means one by one to sequen-tially fill each of the indicating means while maintaining flow through all of the cartridges until the membrane filter media thereof is thoroughly wet by the test liquid;
closing the inlet and connecting chamber to air pressure at about 5 psig to cause all of the test liquid to flow from the chamber through the membrane filter media of all of the cartridges while monitoring all of the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring all of the indicating means to determine that no air bubbles appear in quick sequence in any of the indicating means until the air pressure reaches the acceptable diffusional flow rate test pressure range as predetermined in accordance with the membrane filter media of the cartridges being tested; and draining all test liquid from the chamber, the indicating means and the cartridges.
placing a plurality of cartridges in the chamber of a filter housing at the filtering site with the lower end of the core of each cartridge in communication with the outlet of the housing and the upper end of the core of each cartridge in communication with a different one of a plurality of flow condition indicating means which extend through the top of the housing;
with the outlet closed, venting the top of the chamber and opening the inlet to admit test liquid to fill the chamber;
closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through all of the cartridges to the open outlet;
venting the indicating means one by one to sequen-tially fill each of the indicating means while maintaining flow through all of the cartridges until the membrane filter media thereof is thoroughly wet by the test liquid;
closing the inlet and connecting chamber to air pressure at about 5 psig to cause all of the test liquid to flow from the chamber through the membrane filter media of all of the cartridges while monitoring all of the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring all of the indicating means to determine that no air bubbles appear in quick sequence in any of the indicating means until the air pressure reaches the acceptable diffusional flow rate test pressure range as predetermined in accordance with the membrane filter media of the cartridges being tested; and draining all test liquid from the chamber, the indicating means and the cartridges.
15. The method in accordance with claim 14, and further increasing the air pressure before draining and substantially instantaneously replacing test liquid in all of the indicat-ing means with air to determine the foam all-over point of the cartridges.
16. The method in accordance with claim 14 when air bubbles appear in an indicating means thereby indicating the cartridge in communication therewith is defective, comprising the further steps of:
venting the indicating means with air from air bubbles; and choking the flow through the outlet to maintain a column of test liquid in the vented indicating means until the test is completed.
venting the indicating means with air from air bubbles; and choking the flow through the outlet to maintain a column of test liquid in the vented indicating means until the test is completed.
17. A method of testing a filter with membrane filter media at the site of use, comprising the steps of:
placing a membrane filter in the chamber of housing between inlet and outlet which communicate with the bottom of the chamber;
providing a flow condition indicating means in communication with the upper portion of said chamber on the outlet side of said membrane filter;
with the outlet closed, venting the upper portion of the chamber on the inlet side of said membrane filter and admitting test liquid into the inlet to fill the chamber, closing the vent when test liquid fills the chamber and opening the outlet to provide a continuous flow of test liquid from the outlet through said membrane filter to the outlet;
venting the indicating means only until it is filled with test liquid and maintaining flow through the membrane filter until the membrane is thoroughly wet by the test liquid;
closing the inlet and connecting the inlet side of the chamber to a source of air pressure at about 5 psig while monitoring the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring the indicating means to determine that no air bubbles appear therein in quick sequence until the air pressure is in the acceptable diffusional flow rate test pressure range as predetermined by the membrane of the filter being tested;
disconnecting the air pressure and draining all test liquid from the chamber and the indicating means.
placing a membrane filter in the chamber of housing between inlet and outlet which communicate with the bottom of the chamber;
providing a flow condition indicating means in communication with the upper portion of said chamber on the outlet side of said membrane filter;
with the outlet closed, venting the upper portion of the chamber on the inlet side of said membrane filter and admitting test liquid into the inlet to fill the chamber, closing the vent when test liquid fills the chamber and opening the outlet to provide a continuous flow of test liquid from the outlet through said membrane filter to the outlet;
venting the indicating means only until it is filled with test liquid and maintaining flow through the membrane filter until the membrane is thoroughly wet by the test liquid;
closing the inlet and connecting the inlet side of the chamber to a source of air pressure at about 5 psig while monitoring the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring the indicating means to determine that no air bubbles appear therein in quick sequence until the air pressure is in the acceptable diffusional flow rate test pressure range as predetermined by the membrane of the filter being tested;
disconnecting the air pressure and draining all test liquid from the chamber and the indicating means.
18. The method in accordance with claim 17, and comprising the step of:
venting the chamber and indicating means while connecting the inlet to a drain line for draining the chamber and the indicating means.
venting the chamber and indicating means while connecting the inlet to a drain line for draining the chamber and the indicating means.
19. The method in accordance with claim 18, and further increasing the air pressure before draining and substantially instantaneously replacing test liquid in the indicating means with air to determine the foam all-over point of the membrane.
20. A method of testing membrane type filter cartridges at the site of use, comprising the steps of:
placing a cartridge in the chamber of a filter housing at the filtering site with its core in flow communi-cation at its lower end with the outlet of the housing and at its upper end with a flow condition indicating means extending through the top of the housing;
with the outlet closed, venting the upper portion of the chamber and admitting test liquid into the inlet of the housing to fill the chamber;
closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through the cartridge to the outlet;
venting the indicating means only until it is filled with test liquid and maintaining flow through the cartridge until the membrane media thereof is thoroughly wet by the test liquid;
closing the inlet and connecting the chamber to air pressure at about 5 psig to move all of the test liquid from the chamber through the membrane media while monitoring the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring the indicating means to determine that no air bubbles appear therein in quick sequence until the air pressure is in the acceptable diffusional flow rate test pressure range as pre-determined in accordance with the membrane of the cartridge being tested; and draining all test liquid from the chamber, the indicating means and the cartridge.
placing a cartridge in the chamber of a filter housing at the filtering site with its core in flow communi-cation at its lower end with the outlet of the housing and at its upper end with a flow condition indicating means extending through the top of the housing;
with the outlet closed, venting the upper portion of the chamber and admitting test liquid into the inlet of the housing to fill the chamber;
closing the vent and opening the outlet to provide a continuous flow of test liquid from the inlet through the cartridge to the outlet;
venting the indicating means only until it is filled with test liquid and maintaining flow through the cartridge until the membrane media thereof is thoroughly wet by the test liquid;
closing the inlet and connecting the chamber to air pressure at about 5 psig to move all of the test liquid from the chamber through the membrane media while monitoring the indicating means to determine that no air bubbles appear therein;
increasing the air pressure slowly while monitoring the indicating means to determine that no air bubbles appear therein in quick sequence until the air pressure is in the acceptable diffusional flow rate test pressure range as pre-determined in accordance with the membrane of the cartridge being tested; and draining all test liquid from the chamber, the indicating means and the cartridge.
21. The method in accordance with claim 20, and comprising the step of:
venting the chamber and the indicating means while connecting the inlet to a drain line for draining the chamber, indicating means and cartridge.
venting the chamber and the indicating means while connecting the inlet to a drain line for draining the chamber, indicating means and cartridge.
22. The method in accordance with claim 21, and further increasing the air pressure before draining and substantially instantaneously replacing test liquid in the indicating means with air to determine the foam all-over point of the cartridge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000438681A CA1171363A (en) | 1980-10-30 | 1983-10-07 | Filter cartridge with microporous membrane filter media for mounting in a filter housing |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20285680A | 1980-10-30 | 1980-10-30 | |
| US202,856 | 1980-10-30 | ||
| US265,481 | 1981-05-20 | ||
| US06/265,481 US4384474A (en) | 1980-10-30 | 1981-05-20 | Method and apparatus for testing and using membrane filters in an on site of use housing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000438681A Division CA1171363A (en) | 1980-10-30 | 1983-10-07 | Filter cartridge with microporous membrane filter media for mounting in a filter housing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1165250A true CA1165250A (en) | 1984-04-10 |
Family
ID=26898084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000387353A Expired CA1165250A (en) | 1980-10-30 | 1981-10-06 | Method and apparatus for testing and using membrane filters in an on site of use housing |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4384474A (en) |
| EP (1) | EP0051373B1 (en) |
| AU (1) | AU7617081A (en) |
| BR (1) | BR8107017A (en) |
| CA (1) | CA1165250A (en) |
| DE (1) | DE3173014D1 (en) |
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- 1981-05-20 US US06/265,481 patent/US4384474A/en not_active Expired - Fee Related
- 1981-10-06 CA CA000387353A patent/CA1165250A/en not_active Expired
- 1981-10-08 AU AU76170/81A patent/AU7617081A/en not_active Abandoned
- 1981-10-15 DE DE8181304810T patent/DE3173014D1/en not_active Expired
- 1981-10-15 EP EP81304810A patent/EP0051373B1/en not_active Expired
- 1981-10-29 BR BR8107017A patent/BR8107017A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3173014D1 (en) | 1986-01-02 |
| EP0051373A2 (en) | 1982-05-12 |
| US4384474A (en) | 1983-05-24 |
| EP0051373A3 (en) | 1982-06-23 |
| EP0051373B1 (en) | 1985-11-21 |
| AU7617081A (en) | 1982-05-06 |
| BR8107017A (en) | 1982-07-13 |
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