CA1166108A - Bone prosthesis with controlled stiffness - Google Patents

Bone prosthesis with controlled stiffness

Info

Publication number
CA1166108A
CA1166108A CA000390495A CA390495A CA1166108A CA 1166108 A CA1166108 A CA 1166108A CA 000390495 A CA000390495 A CA 000390495A CA 390495 A CA390495 A CA 390495A CA 1166108 A CA1166108 A CA 1166108A
Authority
CA
Canada
Prior art keywords
bone
prosthesis
structural member
plate
fracture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000390495A
Other languages
French (fr)
Inventor
Frederick J. Kummer
Richard D. Coutts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MTG Divestitures LLC
Original Assignee
Howmedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howmedica Inc filed Critical Howmedica Inc
Application granted granted Critical
Publication of CA1166108A publication Critical patent/CA1166108A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8028—Cushions, i.e. elements forming interface between bone plate and bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8033—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers
    • A61B17/8047—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates having indirect contact with screw heads, or having contact with screw heads maintained with the aid of additional components, e.g. nuts, wedges or head covers wherein the additional element surrounds the screw head in the plate hole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive

Abstract

PC(HO) 6348 BONE PROSTHESIS WITH CONTROLLED STIFFNESS
Abstract A novel bone prosthesis for use in healing a bone fracture is disclosed comprising a strong, rigid non-absorbable structural member and a biologically absorbable element held in use under compression against the structural member. Use of the novel prosthesis combines an excellent initial stabilization of the fixed fracture with a gradual shifting of stress-bearing from the prosthesis to the bone in the fracture region as the fracture heals. Thus, problems associated with stress-shielding during healing are alleviated. The structural member may be, e.q., a bone plate, intramedullary rod or hip nail.

Description

PC(HO) 6348 BONE PROSTHESIS WITH CONTROLLED STIFFNESS

A wide variety of rigid metal prostheses, such as bone plates, intramedullary rods and fPmoral nails, aIe used in the fixation of bone fractures. A
potential problem associated with the use of rigid bone prostheses for fracture fixation is referred to in the art as stress-shielding. As bone remodeling takes place in the region of the fracture, stresses exerted on the healing bone are carried primarily by the prosthesis rather than by the bone in the fracture region. This stress-shielding can be the cause of significant bone resorption, with consequent reduction of strength of the bone in the region of the healed fracture. Shielding of bending stresses from bone undergoing remodeling is believed to be particularly deleterious~ See Bradley, G. W. et al., "Effects of Flexural Rigidity of Plates on Bone Healing", Jour. Bone and Joint Surg., Vol. 61-A, No. 6, pp. 866-872 (September 1979) and Woo, S. L-Y et al., "A Comparison of Cortical Bone Atrophy Secondary to Fixation with Plates with Large Differences in Bending Stiffness", Jour. Bone and Joint Surg., Vol. 58-A, No. 2, pp. 190-195 (March 1976).

The use of bone prostheses made of materials that are substantially less rigid than conventional surgical implant alloys has been proposed in order to alleviate problems arising from stress-shielding.
; One class of materials of reduced rigidity consists of non-absorbable syn~hetic polymers reinforced with inorganic fibers. However, the use of such materials sacrifices the excellent initial stabilization provided by a rigid prosthesis, which insures the maintenance of a proper alignment of bone segments during the early stages of healing.

U. S. Patent 2,987,062 discloses an orthopedic bone fracture clamp adapted to be wrapped around a fractured bone. The clamp comprises two metallic bands directly connected at one pair of ends and joined by a link of absorbable catgut at the other pair of ends. The assembly of bands and absorbable link is placed under tension so as to hold the fractured bone together.
After implantation of the assembly in the patient the link begins to be absorbed. Eventually the link fails and the clamping pressure on the bone is terminated, thereby, according to the patent, obviating the deleterious effects of continued pressure on the bone and eliminating the need for a second surgical operation to remove the clamp. However, the clamping pressure applied to the healing bone would not tend to decrease gradually or progressively with time after implantation.
Instead, it would tend to drop in one full step at the moment of failure of the link from near the initial clamping pressure to zero.

The use of a bone plate having a rigidity that gradually decreases with time after implantation has been proposed by Parsons, J. R. et al., "A Variable Stiffness, Ab~orbable Bone Plate", presented at the Fifth Annual Meeting of the Society for Biomaterials, Clemson, South Carolina, April 28-May 1, 1979. The bone plate proposed by Parsons et al. is made of a material consisting of continuous carbon fibers embedded in a resorbable J ~

matrix of polylactic acid polymer. However, the initial rigidity of this plate is only 20% to 50% that of conventional stainless steel bone plates, and the rigidity decreases by only 10% after six weeks of implantation. Also, the carbon fibers are dispersed throughout the tissue of the patient after absorption of the polylactic acid matrix.
A novel bone prosthesis for use in healing a bone fracture has now been invented comprising a strong, rigid, biologically non-absorbable structural member and a biologically absorbable element adapted to be held under compression against said structural member when said prosthesis is secured to said bone, so that stress is transmitted from said bone through said element to said structural member, whereby the stress transmitted to said prosthesis gradually decreases with time during the healing of said bone as said element is absorbed. The structural member is preferably made of metal, but may also be made of a ceramic, carbonaceous or other material. The biologically absorbable element is preferably made of a synthetic polymeric material, such as a hydroxy-methacrylate polymer, a polypeptide, polyglycolic acid, polylactic acid or a copolymer of polyglycolic acid and polylactic acid, but may also be made of, e.g., a ceramic material such as hydroxyapatite or tricalcium phosphate or a naturally-occurring polymeric material. The structural member of the novel prosthesis of the invention may be, e.g., a bone plate, intramedullary rod or hip nail. The effective overall rigidity of the prosthesis, as experienced by the healing bone, varies progressively with time after 3~

implantation, with stresses transmitted through the healing bone being gradually shifted from the prosthesis to the bone in the fracture region. The rate of decline of said effective rigidity as a function of time can be controlled by proper choice of the material (chemical composition, porosity, molecular weight, degree of crystallinity, monomeric ratio in copolymer, etc.) used for the biologically absorbable element.

A prosthesis of the invention may be designed in such a manner that its effective overall rigidity varies progressively after implantation from almost that of the rigid structural member to zero, with the probability of having to perform a subsequent surgical operation to remove the non-absorbable portion of the prosthesis being substantially lower than when said portion is implanted alone.

The invention will be described in detail with reference to certain preferred embodiments thereof. Reference to these embodiments does not limit the scope of the invention, which is limited only by the scope of the claims.

In the drawings:

FIG. 1 is a front sectional view of a first embodiment of the invention, a bone plate provided with a continuous biologically absorbable coating;

FIG. 2 is a front sectional view of a second embodiment of the invention, a bone plate provided with a plurality of biologically absorbable spacers;

- s -FIG. 3 is a front sectional view of a third embodiment of the invention, a bone plate provided with a plurality of biologically absorbable washers;

FIG. 4 is a front sectional view of a fourth embodiment of the invention, a bone plate provided with a plurality of biologically absorbable gaskets and non-absorbable sleeves;

FIG. 5 is a front sectional view of a fifth embodiment of the invention, an intramedullary rod provided with a continuous biologically absorbable coating; and FIG. 6 iS sectional view taken along line 6-6 of F:[G. 5.

FIG. 1 is a front sectional view of a first embodiment of the invention, bone prosthesis 1, secured to bone fragments 8 and 9 so as to effect the healing of a fracture between said bone fragments represented by fracture line F. Prosthesis 1 comprises a metallic structural member 2 and a biologically absorbable element 3. Structural member 2 is a conventional bone plate. Prosthesis 1 is secured to the bone by means of a plurality of conventional metallic bone screws 4 to 7 fitted through a plurality of circular apertures in member 2. Structural member 2 and bone screws 4 to 7 are made of a strong, rigid, biologically non-absorbable surgical implant alloy such as the cobalt-chromium-molybdenum alloy manufactured and sold under the trademark Vitallium (Howmedica, Inc.; ~ew York, New York) or 316L stainless steel.

i~t~ 8 Element 3 is a biologically absorbable continuoùs coating molded to the bottom face of member 2 and having the same length and width as said face. Element 3 is typically from about 0.1 mm. to about 1 mm. in thickness.
The absorbable coating is provided with a plurality of circular bone screw apertures coinciding with those in member 2. Element 3 is made of a synthetic polymeric material, preferably polyglycolic acid, polylactic acid or a polyglycolic acid:polylactic acid copolymer.
As can be seen in FIG. 1, element 3 is held under com-pression between structural member 2 and bone fragments 8 and 9 when prosthesis 1 is secured to said fragments by means of bone screws 4 to 7. The face of element 3 held adjacent to the bone fragments may be textured to allow for access of blood to the bone. Immediately after implantation, virtually all of the stresses transmitted between bone fragments 8 and 9 are trans-mitted through element 3 and carried by member 2, since they cannot be transmitted across the fracture line F.
The rigidity of prosthesis 1 experienced by the bone fragments immediately after fixation is almost that of a conventional rigid metallic bone plate.

As time passes after implantation, two phenomena occur simultaneously. First, the fracture between fragments ~5 8 and 9 begins to heal, thus reducing the need for stress-shielding. Second, element 3 is gradually absorbed by the bodily fluids and is thus gradually weakened. As these two phenomena occur, the pathway of stress trans-mission between bone fragments 8 and 9 is gradually shifted so that with passing time progressively more stress is transmitted directly through the healing bone in the region of original fracture line F and , progressively less stress is transmitted through prosthesis 1. Finally, as the absorption of element 3 nears completion, virtually all of the stresses are carried by the healed bone itself; the probability of having to perform a subsequent surgical operation to remove the non-absorbable portion of the prosthesis is substantially lower than when said portion is implanted by itself without element 3.

Alternate designs for biologically absorbable elements for use with structural member 2 and screws 4 to 7 are shown in FIGS. 2, 3 and 4. In FIG. 2, the continuous coating 3 of FIG. 1 has been replaced by a plurality of discrete, generally rectangular biologically absorbable spacers 11 to 13 molded to the bottom face of structural member 2. The width of said spacers, i.e. the dimension extending perpendicularly to the plane of FIG. 2, is the same as the width of the bottom face of member 2. In FIG. 3, the continuous coating 3 of FIG. 1 has been replaced by a plurality of biologically absorbable washers 21 to 24 for screws 4 to 7. Washers 21 to 24 are not molded to structural member 2, and are separable therefrom when the pros-thesis of FIG. 3 is not in use. In FIG. 4, the con-tinuous coating 3 of FIG. 1 has been replaced by a plurality of biologically absorbable gaskets 31 to 34 for screws 4 to 7. Additionally, the prosthesis con-tains a plurality of non-absorbable polymeric, e.g.
polyethylene, sleeves 41 to 44 located within the bone screw apertures of structural member 2 to prevent fretting of bone screws 4 to 7 against member 2.
Gaskets 31 to 34 and sleeves 41 to 44 are separable from member 2 when the prosthesis of FIG. 4 is not in use.

`8 FIG. 5 is a front sectional view of a fifth embodiment of the invention, bone prosthesis 101, which has been driven into the medullary canal 110 of a fractured bone so as to effect the healing of a fracture, represented by fracture line L, between bone fragments 108 and 109. Prosthesis 101 comprises a metallic structural member 102, which is a conventional intra-medullary rod, and a biologically absorbable element 103, which is a continuous coating molded to the exterior surface of member 102. As can be seen in FIG. 6, both member 102 and element 103 are circular in transverse cross-section, subtending an angle of about 270. Structural member 102 is made of a strong, rigid, biologically non-absorbable surgical implant alloy such as the cobalt-chromium-molybdenum alloy manufactured and sold under the trademark Vitallium ~owmedica, Inc.; New York, New York). Element 103 is made of a synthetic polymeric material, preferably poly-glycolic acid, polylactic acid or a polyglycolic acid:polylactic acid copolymer. As can be seen in FIGS.
5 and 6, element 103 is held under compression between structural member 102 and bone fragments 108 and 109 when prosthesis 101 is driven into the medullary canal of the fractured bone. As bone healing and absorption of element 103 occur simultaneously after implantation, stress t~ansmission is gradually shifted from prosthesis 101 to the bone in the region of original fracture line in an analogous manner as described above with regard to the prostheses of FI~S. 1 to 4. Again, the probability of having to perform a subsequent surgical operation to remove structural member 102 is substantially reduced.

Claims (9)

PC(HO) 6348
1. A bone prosthesis for use in healing a bone fracture comprising a strong, rigid, biologically non-absorbable structural member and a biologically absorbable element adapted to be held under compression against said structural member when said prosthesis is secured to said bone, so that stress is transmitted from said bone through said element to said structural member, whereby the stress transmitted to said prosthesis gradually decreases with time during the healing of said bone as said element is absorbed.
2. A prosthesis of claim 1 wherein said element is adapted to be held between said structural member and said bone when said prosthesis is secured to said bone.
3. A prosthesis of claim 2 wherein said structural member is a bone plate and said element is affixed to said plate.
4. A prosthesis of claim 2 wherein said structural member is an intramedullary rod and said element is affixed to the exterior of said rod.
5. A prosthesis of claim 1 wherein said structural member is a bone plate adapted to be secured to said bone by means including a bone screw fitted through an aperture in said plate, and said element is a gasket held between said screw and said plate.
6. A prosthesis of claim 2 wherein said structural member is a bone plate adapted to be secured to said bone by means including a bone screw adapted to be fitted through an aperture in said plate, and said element is a washer for said screw held between said plate and said bone.
7. A prosthesis of claim 1 wherein said structural member is made of metal.
8. A prosthesis of claim 1 wherein said element is made of a polymeric material.
9. A prosthesis of claim 8 wherein said element is made of a synthetic polymeric material.
CA000390495A 1980-11-21 1981-11-20 Bone prosthesis with controlled stiffness Expired CA1166108A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/208,906 US4338926A (en) 1980-11-21 1980-11-21 Bone fracture prosthesis with controlled stiffness
US208,906 1980-11-21

Publications (1)

Publication Number Publication Date
CA1166108A true CA1166108A (en) 1984-04-24

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Family Applications (1)

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CA000390495A Expired CA1166108A (en) 1980-11-21 1981-11-20 Bone prosthesis with controlled stiffness

Country Status (5)

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US (1) US4338926A (en)
EP (1) EP0052998B1 (en)
JP (1) JPS57117852A (en)
CA (1) CA1166108A (en)
DE (1) DE3165445D1 (en)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573458A (en) * 1982-08-17 1986-03-04 Zimmer, Inc. Bone fixation plate
FI69402C (en) * 1983-09-20 1986-02-10 Materials Consultants Oy OSTEOSYNTESANORDNING
GB8400932D0 (en) * 1984-01-13 1984-02-15 Geistlich Soehne Ag Bone fracture fixation plates
US4863475A (en) * 1984-08-31 1989-09-05 Zimmer, Inc. Implant and method for production thereof
DE3442004C1 (en) * 1984-11-16 1986-04-24 Otte, Heinz, Dr.med., 8712 Volkach Bone fixation apparatus for the treatment of fractures
GB8515870D0 (en) * 1985-06-22 1985-07-24 Showell A W Sugicraft Ltd Bone fixation plates
US5013315A (en) * 1985-07-12 1991-05-07 Minnesota Mining And Manufacturing Company Semiabsorbable bone plate spacer
US4973333A (en) * 1985-09-20 1990-11-27 Richards Medical Company Resorbable compressing screw and method
US4776329A (en) * 1985-09-20 1988-10-11 Richards Medical Company Resorbable compressing screw and method
US4693720A (en) * 1985-09-23 1987-09-15 Katecho, Incorporated Device for surgically repairing soft tissues and method for making the same
FR2596978A1 (en) * 1986-04-10 1987-10-16 Peters BONE FIXING PLATE, PROVIDED WITH SUTURE WIRES
US4832686A (en) * 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4781183A (en) * 1986-08-27 1988-11-01 American Cyanamid Company Surgical prosthesis
NZ222159A (en) * 1986-10-27 1989-12-21 Johnson & Johnson Prod Inc Absorbable bone plate
EP0270704B1 (en) * 1986-12-12 1989-04-26 Aesculap Ag Anchoring element for fastening an osteosynthesis plate to a bone
SU1651778A3 (en) * 1986-12-19 1991-05-23 Хута Баильдон, Пшедсембиорство Паньствове (Инопредприятие) Appliance for ostheosynthesis of fractures of the femoral neck
US4756307A (en) * 1987-02-09 1988-07-12 Zimmer, Inc. Nail device
US4774933A (en) * 1987-05-18 1988-10-04 Xomed, Inc. Method and apparatus for implanting hearing device
JP2564183B2 (en) * 1987-11-03 1996-12-18 ジンテーズ アクチエンゲゼルシャフト Bone graft
DE3805303C1 (en) * 1988-02-20 1989-06-01 Medi-System Gmbh, 4400 Muenster, De
DE3838774A1 (en) * 1988-11-11 1990-05-17 Mecron Med Prod Gmbh SLIDING PLATE
DE3841288A1 (en) * 1988-12-08 1990-06-13 Pertti Prof Dr Toermaelae OSTEOSYNTHESE IMPLANTS
FI82805C (en) * 1988-12-23 1991-04-25 Biocon Oy EN POLYMER FIXERINGSKIVKONSTRUKTION FOER KIRURGISKT BRUK.
US5474553A (en) * 1989-04-18 1995-12-12 Rainer Baumgart System for setting tubular bone fractures
CA1317173C (en) * 1989-11-08 1993-05-04 Amnon Foux Plate for broken bone fixation
AU1443692A (en) * 1991-02-20 1992-09-15 Danek Medical, Inc. Improved external fixation frame assembly
EP0523926A3 (en) * 1991-07-15 1993-12-01 Smith & Nephew Richards Inc Prosthetic implants with bioabsorbable coating
US5201733A (en) * 1992-01-21 1993-04-13 Etheredge Iii James L Method and apparatus for internal fixation of fractures
DE4205118C1 (en) * 1992-02-13 1993-07-29 Dietmar Dr.Med. Priv. Doz. 5000 Koeln De Pennig
FR2688139B1 (en) * 1992-03-06 1995-06-23 Zimmer Sa NEW COATING FOR PROSTHETIC SYSTEM.
WO1993021847A1 (en) * 1992-04-29 1993-11-11 Danek Medical, Inc. Positionable spinal fixation device
US5599290A (en) * 1992-11-20 1997-02-04 Beth Israel Hospital Bone fracture prevention garment and method
DE4414675C1 (en) * 1994-04-27 1995-09-28 Kirsch Axel Covering device for bone defects and method for their production
US5529736A (en) * 1994-08-10 1996-06-25 Clemson University Process of making a bone healing device
US6206881B1 (en) * 1995-09-06 2001-03-27 Synthes (Usa) Bone plate
CA2158890C (en) * 1995-09-22 2002-01-22 John Runciman Spherical washer for use with a bone screw
ES2238736T3 (en) * 1996-12-03 2005-09-01 Osteobiologics, Inc. BIODEGRADABLE POLYMER FILM.
US6004323A (en) * 1997-02-04 1999-12-21 The University Of Iowa Research Foundation Surgically implantable fastening system
US6139550A (en) * 1997-02-11 2000-10-31 Michelson; Gary K. Skeletal plating system
EP1402835B1 (en) * 1997-02-11 2011-09-28 Warsaw Orthopedic, Inc. Single-lock anterior cervical plating system
ES2268267T3 (en) * 1997-02-11 2007-03-16 Warsaw Orthopedic, Inc. PREVIOUS CERVICAL PLATE FOR UNIQUE TYPE LOCK DEVICE.
US5810821A (en) * 1997-03-28 1998-09-22 Biomet Inc. Bone fixation screw system
US5951557A (en) * 1997-12-30 1999-09-14 Luter; Dennis W. Bone plate
US6063117A (en) * 1998-01-22 2000-05-16 Perry; Arthur C. Porous orbital implant structure
SI1112095T1 (en) * 1998-09-11 2003-04-30 Gerhard Dr. Schmidmaier Biologically active implants
US6350284B1 (en) * 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration
US6296645B1 (en) 1999-04-09 2001-10-02 Depuy Orthopaedics, Inc. Intramedullary nail with non-metal spacers
US6783529B2 (en) 1999-04-09 2004-08-31 Depuy Orthopaedics, Inc. Non-metal inserts for bone support assembly
US6187008B1 (en) 1999-07-07 2001-02-13 Bristol-Myers Squibb Device for temporarily fixing bones
AU7118100A (en) * 1999-09-03 2001-04-10 Daniel J. Cook Temporary spine fixation device and method
EP1211993B1 (en) * 1999-09-14 2005-10-26 Dietmar Prof. Dr. Wolter Fixation system for bones
US6540746B1 (en) * 1999-09-30 2003-04-01 Sulzer Orthopedics Ltd. Bone plate for splinting a fracture at a bone with a plurality of bone screws
MXPA02007226A (en) * 2000-01-27 2002-12-09 Synthes Ag Bone plate.
US6808527B2 (en) 2000-04-10 2004-10-26 Depuy Orthopaedics, Inc. Intramedullary nail with snap-in window insert
US6527775B1 (en) 2000-09-22 2003-03-04 Piper Medical, Inc. Intramedullary interlocking fixation device for the distal radius
US6666868B2 (en) 2001-03-02 2003-12-23 Medicinelodge, Inc. Two-part orthopedic fastener
US7122037B2 (en) * 2001-05-17 2006-10-17 Inion Ltd. Bone fracture fastener and material for production thereof
AU2001258138B2 (en) 2001-05-28 2004-10-28 Synthes Gmbh Bone plate for the fixation of fractures of the proximal humerus
US6692507B2 (en) * 2001-08-23 2004-02-17 Scimed Life Systems, Inc. Impermanent biocompatible fastener
US6749639B2 (en) 2001-08-27 2004-06-15 Mayo Foundation For Medical Education And Research Coated prosthetic implant
US20060142765A9 (en) * 2001-10-15 2006-06-29 Dixon Robert A Vertebral implant for bone fixation or interbody use
FR2845588B1 (en) * 2002-10-09 2006-12-15 Biotech Internat SELF-LOCKING OSTEOSYNTHESIS DEVICE
DE20300987U1 (en) * 2003-01-23 2003-04-10 Stryker Trauma Gmbh Implant for osteosynthesis
US7951176B2 (en) 2003-05-30 2011-05-31 Synthes Usa, Llc Bone plate
DE20321552U1 (en) 2003-08-26 2007-12-27 Synthes Gmbh bone plate
US11259851B2 (en) 2003-08-26 2022-03-01 DePuy Synthes Products, Inc. Bone plate
JP2007506452A (en) * 2003-09-08 2007-03-22 ジンテーズ　アクチエンゲゼルシャフト　クール Bone fixation device
US8979900B2 (en) 2003-09-24 2015-03-17 DePuy Synthes Products, LLC Spinal stabilization device
US7137985B2 (en) 2003-09-24 2006-11-21 N Spine, Inc. Marking and guidance method and system for flexible fixation of a spine
US8105367B2 (en) 2003-09-29 2012-01-31 Smith & Nephew, Inc. Bone plate and bone plate assemblies including polyaxial fasteners
US20050085814A1 (en) * 2003-10-21 2005-04-21 Sherman Michael C. Dynamizable orthopedic implants and their use in treating bone defects
US7699879B2 (en) * 2003-10-21 2010-04-20 Warsaw Orthopedic, Inc. Apparatus and method for providing dynamizable translations to orthopedic implants
ES2322575T3 (en) * 2003-10-30 2009-06-23 Synthes Gmbh OSTEOSYNTHESIS PLATE.
ATE540628T1 (en) * 2003-12-01 2012-01-15 Smith & Nephew Inc HUMERAL NAIL WITH INSERT FOR FIXING A SCREW
US20050209603A1 (en) 2003-12-02 2005-09-22 St. Francis Medical Technologies, Inc. Method for remediation of intervertebral disks
US20050136764A1 (en) * 2003-12-18 2005-06-23 Sherman Michael C. Designed composite degradation for spinal implants
US11291484B2 (en) 2004-01-26 2022-04-05 DePuy Synthes Products, Inc. Highly-versatile variable-angle bone plate system
US7637928B2 (en) * 2004-01-26 2009-12-29 Synthes Usa, Llc Variable angle locked bone fixation system
US8574268B2 (en) * 2004-01-26 2013-11-05 DePuy Synthes Product, LLC Highly-versatile variable-angle bone plate system
US7468069B2 (en) 2004-02-10 2008-12-23 Atlas Spine, Inc. Static anterior cervical plate
US7485133B2 (en) * 2004-07-14 2009-02-03 Warsaw Orthopedic, Inc. Force diffusion spinal hook
US7588577B2 (en) 2004-07-15 2009-09-15 Wright Medical Technology, Inc. Guide assembly for intramedullary fixation and method of using the same
US20060015101A1 (en) 2004-07-15 2006-01-19 Wright Medical Technology, Inc. Intramedullary fixation assembly and devices and methods for installing the same
US7288095B2 (en) 2004-08-12 2007-10-30 Atlas Spine, Inc. Bone plate with screw lock
WO2006032362A2 (en) * 2004-09-17 2006-03-30 Michael Buhr Partially resorbable osteosynthetic products
WO2006069089A2 (en) 2004-12-21 2006-06-29 Packaging Service Corporation Of Kentucky Cervical plate system
US7322984B2 (en) 2005-01-06 2008-01-29 Spinal, Llc Spinal plate with internal screw locks
US7438715B2 (en) * 2005-01-06 2008-10-21 Spinal Llc Spinal implant kit
US7410488B2 (en) 2005-02-18 2008-08-12 Smith & Nephew, Inc. Hindfoot nail
US20060242813A1 (en) * 2005-04-29 2006-11-02 Fred Molz Metal injection molding of spinal fixation systems components
US20060271048A1 (en) * 2005-05-12 2006-11-30 Jeffery Thramann Pedicle screw based vertebral body stabilization apparatus
US7828830B2 (en) * 2005-05-12 2010-11-09 Lanx, Inc. Dynamic spinal stabilization
US9060820B2 (en) 2005-05-18 2015-06-23 Sonoma Orthopedic Products, Inc. Segmented intramedullary fracture fixation devices and methods
US8961516B2 (en) 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
US7909825B2 (en) 2006-11-22 2011-03-22 Sonoma Orthepedic Products, Inc. Fracture fixation device, tools and methods
US20060264951A1 (en) 2005-05-18 2006-11-23 Nelson Charles L Minimally Invasive Actuable Bone Fixation Devices Having a Retractable Interdigitation Process
US8287539B2 (en) 2005-05-18 2012-10-16 Sonoma Orthopedic Products, Inc. Fracture fixation device, tools and methods
GB0513647D0 (en) * 2005-07-02 2005-08-10 Greater Glasgow Health Board S Supra mucosal bone fixation
US8382807B2 (en) 2005-07-25 2013-02-26 Smith & Nephew, Inc. Systems and methods for using polyaxial plates
JP5270339B2 (en) 2005-07-25 2013-08-21 スミス アンド ネフュー インコーポレーテッド System and method for using a multi-axis plate
US20070191848A1 (en) * 2006-02-01 2007-08-16 Zimmer Technology, Inc. Hydrogel bone plate spacer
EP2010104B1 (en) * 2006-04-25 2018-09-05 Teleflex Medical Incorporated Calcium phosphate polymer composite and method
US8309521B2 (en) * 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US20090082816A1 (en) * 2007-09-20 2009-03-26 Graham Matthew R Remodelable orthopaedic spacer and method of using the same
US20090130620A1 (en) * 2007-11-19 2009-05-21 Mohamadreza Yazdi Bone supported palatal expansion appliance
US8771283B2 (en) 2007-12-17 2014-07-08 Wright Medical Technology, Inc. Guide assembly for intramedullary fixation and method of using the same
CA2738478A1 (en) 2008-09-26 2010-04-01 Sonoma Orthopedic Products, Inc. Bone fixation device, tools and methods
BRPI0920250A2 (en) 2008-10-15 2016-11-22 Smith & Nephew Inc composite internal fasteners
US8246664B2 (en) * 2009-02-24 2012-08-21 Osteomed Llc Multiple bone fusion plate
CA2794019C (en) 2009-03-24 2019-09-10 Stabiliz Orthopedics, LLC Orthopedic fixation device with bioresorbable layer
US8529608B2 (en) 2009-04-28 2013-09-10 Osteomed Llc Bone plate with a transfixation screw hole
US8652183B1 (en) 2009-07-07 2014-02-18 Mari S Truman Multi-angle orthopedic expansion head fastener
DK2453939T3 (en) * 2009-07-16 2014-02-03 Anatoli D Dosta bone implants
US8758346B2 (en) * 2009-09-14 2014-06-24 DePuy Synthes Products, LLC Variable angle compression plate
CN103717179B (en) 2011-06-15 2017-08-08 史密夫和内修有限公司 Variable angle locked implant
DE102012006454A1 (en) * 2012-03-30 2013-10-02 Heraeus Medical Gmbh Anti-infective spacer for osteosynthesis plates
FR2994380B1 (en) * 2012-08-13 2015-07-17 Biotech Ortho COATING PLATE OF BONE FRAGMENTS AND METHODS OF MAKING SUCH PLATE.
EP3323364A1 (en) * 2013-04-12 2018-05-23 Zimmer GmbH Orthopedic plate
CN103654928A (en) * 2013-12-10 2014-03-26 徐斌 Self-releasing-type internal fracture fixation system
US9770278B2 (en) 2014-01-17 2017-09-26 Arthrex, Inc. Dual tip guide wire
US20150265325A1 (en) * 2014-03-24 2015-09-24 Robert G Matheny Sternal Closure Apparatus, System and Method
CN103961168A (en) * 2014-05-14 2014-08-06 徐斌 Reinforcing bar for supporting pore passage of bone nail
US9814499B2 (en) 2014-09-30 2017-11-14 Arthrex, Inc. Intramedullary fracture fixation devices and methods
CH710695B1 (en) 2015-02-03 2022-11-30 Brianza Stefano Device for variable fixation of bone fragments.
US11707306B2 (en) * 2015-06-09 2023-07-25 Cheng Xin She Fixing bone plate
WO2017048909A1 (en) 2015-09-18 2017-03-23 Smith & Nephew, Inc. Bone plate
US10905476B2 (en) 2016-09-08 2021-02-02 DePuy Synthes Products, Inc. Variable angle bone plate
US10624686B2 (en) 2016-09-08 2020-04-21 DePuy Synthes Products, Inc. Variable angel bone plate
US10820930B2 (en) 2016-09-08 2020-11-03 DePuy Synthes Products, Inc. Variable angle bone plate
US11426220B2 (en) 2017-10-11 2022-08-30 Howmedica Osteonics Corp. Humeral fixation plate guides
WO2019136122A1 (en) 2018-01-03 2019-07-11 Lee Thomas Hoon Hybrid cannulated orthopedic screws
WO2019140438A1 (en) 2018-01-15 2019-07-18 Sands Steven Saam Hybrid intramedullary rods
US11026727B2 (en) 2018-03-20 2021-06-08 DePuy Synthes Products, Inc. Bone plate with form-fitting variable-angle locking hole
US10772665B2 (en) 2018-03-29 2020-09-15 DePuy Synthes Products, Inc. Locking structures for affixing bone anchors to a bone plate, and related systems and methods
US11013541B2 (en) 2018-04-30 2021-05-25 DePuy Synthes Products, Inc. Threaded locking structures for affixing bone anchors to a bone plate, and related systems and methods
US11701150B2 (en) * 2018-08-24 2023-07-18 Laboratoires Bodycad Inc. Patient-specific fixation plate with spacing elements
US10925651B2 (en) 2018-12-21 2021-02-23 DePuy Synthes Products, Inc. Implant having locking holes with collection cavity for shavings
EP3941373A1 (en) 2019-03-18 2022-01-26 GLW, Inc. Hybrid bone plate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2136471A (en) * 1937-06-30 1938-11-15 Rudolph H Schneider Bone pin
US2987062A (en) * 1956-07-23 1961-06-06 Arthur E Ellison Bone splint with absorbable section
US3739773A (en) * 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
US3875937A (en) * 1963-10-31 1975-04-08 American Cyanamid Co Surgical dressings of absorbable polymers
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
US3272204A (en) * 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands
US3596656A (en) * 1969-01-21 1971-08-03 Bernd B Kaute Fracture fixation device
DE6938553U (en) * 1969-10-03 1976-06-10 Artur Fischer RAIL FOR SURGICAL PURPOSES TO CONNECT BROKEN BONE PARTS.
BE758156R (en) * 1970-05-13 1971-04-28 Ethicon Inc ABSORBABLE SUTURE ELEMENT AND ITS
US3918100A (en) * 1974-05-13 1975-11-11 Us Navy Sputtering of bone on prostheses
US3892649A (en) * 1974-05-13 1975-07-01 Us Navy Electrodeposition of bone within a plastic matrix
JPS5839533B2 (en) * 1975-12-30 1983-08-30 住友化学工業株式会社 Implant noseizouhouhou
US4186448A (en) * 1976-04-16 1980-02-05 Brekke John H Device and method for treating and healing a newly created bone void
AT352867B (en) * 1976-05-12 1979-10-10 Battelle Institut E V BONE REPLACEMENT, BONE COMPOUND OR PROSTHESIS ANCHORING MATERIAL AND PROCESS FOR ITS PRODUCTION
FR2439003A1 (en) * 1978-10-20 1980-05-16 Anvar NEW OSTEOSYNTHESIS PARTS, THEIR PREPARATION AND THEIR APPLICATION
US4281420A (en) * 1979-02-15 1981-08-04 Raab S Bone connective prostheses adapted to maximize strength and durability of prostheses-bone cement interface; and methods of forming same
US4292695A (en) * 1980-06-25 1981-10-06 Lord Corporation Prosthesis stem
US4292694A (en) * 1980-06-25 1981-10-06 Lord Corporation Prosthesis anchoring means

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DE3165445D1 (en) 1984-09-13
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US4338926A (en) 1982-07-13
EP0052998A1 (en) 1982-06-02
JPS57117852A (en) 1982-07-22

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