CA1292212C - Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament - Google Patents

Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament

Info

Publication number
CA1292212C
CA1292212C CA 579849 CA579849A CA1292212C CA 1292212 C CA1292212 C CA 1292212C CA 579849 CA579849 CA 579849 CA 579849 A CA579849 A CA 579849A CA 1292212 C CA1292212 C CA 1292212C
Authority
CA
Canada
Prior art keywords
hollow part
needle
open end
seat
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 579849
Other languages
French (fr)
Inventor
Mario Coccia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of CA1292212C publication Critical patent/CA1292212C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2051Connecting means having tap means, e.g. tap means activated by sliding
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00Surgery
    • Y10S604/905Aseptic connectors or couplings, e.g. frangible, piercable

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Catching Or Destruction (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Reciprocating Pumps (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Basic Packing Technique (AREA)

Abstract

Abstract:
APPARATUS WITH SAFETY LOCKING MEMBERS, FOR CONNECTING A SYRINGE TO
A BOTTLE CONTAINING A MEDICAMENT

The invention relates to an apparatus for connecting a bottle containing a medicament to a syringe the needle of which is housed in a closed chamber defined by the apparatus and from which the needle can be made to emerge by sliding the separate constituent parts of the apparatus along each other. To prevent the needle emerging from said chamber when no bottle is housed in the appropriate seat provided in the apparatus, there extends from one of the parts of the apparatus an elongated flexible appendix having at least one protuberance which projects into said seat and against which the bottle presses when inserted into the seat, so bending the appendix outwards. In front of the free end of the appendix there is provided a stop tooth projecting from that constituent part of the apparatus which is mobile along the first stated part and extends totally around said seat. When no bottle is inserted into the seat in the apparatus it is impossible to move the various parts of the apparatus along each other because the free end of the flexible appendix makes contact with and halts against said stop tooth, to thus prevent the needle emerging from said chamber.

Description

APPARATUS WITH SA~ETY LCCXING ~EMBERS, FOR CON~ECTI~G A SYRI~GE TO
A BOTTLE CONTAI~ING A ~EE~ICAME~T

The invention relates ta an improvement in apparatus for connecting a bottle containing a medicament to a syringe used to withdraw the medicament from the bottle, possibly af-ter feeding into this latter a solvent or the llke.

~ore specifically, the said apparatus is of the type described in US~ patent ~o. 4,576,~11. It cor~prises several mutually mabile constituent parts and at one end contains a seat into which the end of a syringe can be fitted so that its naedle extends into a closed chamber bounded by the apparatus which, at its other end, co~prlses a seat for housing the mouth of a bottle containing a =dicament. The various constituent parts of the apparatus can move axially along each other to securely lock the bottle mou-th in its seat by means of retention teeth projecting from flexible tongues, and to cause the point and a portion of the needle to emerge from its chamber so that~the needle can perforate the elastic plug fitted to the bottle opening and penetrate in-to the ~ottle, to be able to ln~ect into it any liquid contained in the syrin3e ar to draw into the syringe the liquid contained ln the bottle. ~

~bile the bottle is connec-ted to the apparatus the needle ls al~lays contained within the apparatus chamber or (partly) within -the battle, ie the needle is never freely e~posed and accessible from the outside.

The apparatus of USA patent 4,~7~ l1 has ho~iever the drawback :
:
:

,~
that if no bottle is inserted into its seat in the apparatus, this can still be erroneously or accidentally operated in the sense of moving the various component parts along each other to cause the needle to emerge from its protection chamber. In such a case the needle would project outwards from the apparatus and be accessible from the outside, with consequent danger in terms of loss of needle sterility and even greater danger if a high-risk medicament such as an antitumoral drug has already been drawn into the syringe.
The object of the present invention is therefore to obviate the aforesaid drawbacks, ie to prevent the various constituent parts of the apparatus being able to move along each other when no bottle mouth (or the like) is inserted into its seat in the apparatus, to thus preven-t the needle emerging from the closed chamber provided in the apparatus.
Therefore this invention seeks to provide an apparatus for connecting a syringe to a bottle having a lip surrounding a mouth, said apparatus comprising:
(a) a radially inner hollow part having a first end containing a first seat -or a syringe and a second end;
(b) an intermediate hollow part slidably received in said radially inner hollow part and having a Eirst open end and a second open end;
(c) a radially outer part slidably received on said intermediate hollow part and having a first end and a second end;
(d) a perforable plug received in said second open end of said intermediate hollow part;
(e) a plurality of flexible retention elements ~2Z~ 2 projecting axially from said second open end oE said intermediate hollow part radially outwardly of sald perforable plug;
(f) at leas-t one flexible appendix projecting axially from said second open end of said intermedia~e hollow part radially outwardly of said perforable plug;
(g) at least one stop tooth projecting axially from said second open end of said radially outer part towards sald at least one flexible appendix; and (h) means for limiting the axial movement of said parts relative to each other so as to define a :Eirst position, in which the overall length of said apparatus is at a maximum, and a second position, in which the overall length of said apparatus is at a minimum, wherein (i) said radially inner hollow part and said first open end of said intermediate part together define a chamber which, in the first positlon of said apparatus, has an axial length such :: that, in use, it entirely contains a needle in fluid communication ; with a syringe received in said first seat and which, in the second position of said apparatus, has an axial length such that, in use, the:same needle projects through said perforable plug;
(jj said plurality of flexi~ble retention elemen-ts and : sa:id second open end of said~intermediate hollow part together define a second seat sized, shaped, and positioned to receive and to grip the lip of a bottle; and~
: ~ (k) said at least one:flexible appendix is sized5:
shaped, and positioned so tha-t:
(i) it is cammed radially outwardly when the lip of a~bottl~ is received in said second seat, permitting said 21~

2b apparatus to assume its second position, and (li) when it is not cammed radially outwardly, it abuts against said at least one stop tooth at a point during the axial movement of said parts relative to each other that prevent said apparatus from assuming its second position.
The structure and characteristics of the apparatus will be more apparent from the description given hereinafter by way of non-limiting example with reference to the accompanying drawing, in I

~9~2i2 which:
Pi~ure 1 is a partly sectlonal view of the apparatus ln lts rest state, wlth the needle completely retracted into the closed chamber of the apparatus;
~lgure 2 shows the same apparatus connected to a bottle ~outh and wlth the syrlnge needle pro~ecting from the closed chamber and extendlng lnto the bottle; and Pigure 3 shows only an end portlan af the apparatus in the state shown ln Figure 2, but with a battle necX af different thickness from that shown in Figura 2.

The apparatus shown on the drawlng comprises three separate main constltuent partst namely the parts 1, 2 and 3. Plns 4 are rigid with one of these parts and extend radlally into axially extending groaves farmed in the ather twa parts. In this manner -the three parts 1, 2 and 3 are coupled ta each ather but can be moved a~ially alang each ather.

The part 1 camprises a seat ~nat sho~n) to house and retain the free end of a syringe 5. With the said part 1 there is rigid a ~eedle 6 which when the apparatus i5 in use is securely connected to the syrlnge inle-t and outlet hole.

When the apparatus ls in its rest state, ie not in use (Figure 1), the needle 6 is completely enclosed and pratected within a chamber 7 defined by the parts 1 and 2. At its lower end, below the needle point, it comprises a hole hermetically sealed by a perfarable plug 8 af rubber ar a simllar materlal.

The part 3 extends downwards fram the apparatus ~wlth referenc~ to the flgures of the drawing) beyond the part 2 in the form of a shaped continuous tubular wall 9 which has its free end enlarged in an lnward dlrection and into which from the lower end of the part 2 there extend the flexible retention elements 10, the outer surface of which is such as not to interfere with the free edge of the wall 9 when the parts 1, 2 and 3 are superposed on each other ~to their maxlmum qxtent ~Fl~ure 2~, provlded that sald appendlces :

are free, ie provided no bottle ls Gonnected to the described apparatus.

In this respect, the retention elements lC define a housin~ seat ln which the mouth of a bottle ll for contalnlng medicaments can be lnserted and retalned. In Fl~ure 1 no bottle is lnserted in lts housin~ seat, the apparatus ls ln lts rest state and the elements 10 can bend bo-th lnwards and outwards. Under these conditlons ~Fl~ure 1), if the mouth of a bottle 11 is lnserted into the seat defined by the elements 10 these are bent freely outwards by the bottle neck, which interferes with the protuberances pro~ecting from these elements. When the bottle 11 has been lnserted into its seat in the described manner, the parts 1, 2 and 3 can be moved along each other ~Figure 2) so that the free edge of the wall 9 rests against the outer surface of the elements 10, whlch can therefore not bend further outwards. The result is that when in this position the protuberances pro~ectlng lnwards from the elements 10 are locked under the nec~ of the battle, which can therefore not be removed from the apparatus. It will be noted that when the apparatus is in the position shown in ~igure 1, the needle is completely housed within the chamber 7, whereas when in the position shown iD Fi~ure 2 the needle has passed through the plu~ and extends into the bottle 11.

The apparatus described up to this point is of well known type, and is illustrated in USA patent No. 4,576,211. This apparatus has~co~siderable merit, but has the drawback that lf no bottle ls lnserted between the elements 10, -the parts 1, 2 and 3 can still be moved freely alon~ each other to cause the needle to emer~e fram the closed chamber of the apparatus. The polnt of the needle and a portlon thereof are therefore exposed and freely extendin~
olltslde the apparatus, a sltuatlon which can be very dan~erous if the syringe is fllled with a potentially toxlc medicament, such as an antltumoral dru~.
::
To prevent thls happening, le to allow the needle polnt to pass ~ ~ beyond the plu~ 8 only when the mouth of a bottle 11 Is inserted :: : ~: :

;~2~2~1~

between -the retention elements 10, according to the present invention there proJects from the lower end of the part 2 at least one flexible appendix 12 havin~ a protuberance 13 proJecting towards the seat deflned by the inner surfaces of the retentlon elements 10. The free end of a tooth 1~ which pro~ects upwards from the edge of the wall 9 of the part 3 is positioned in front o~ the free end of the appendix 12 (when ln the rest state of Figure 1~.

Assuming that the condltions of Figure 1 apply, lf an attempt is made to slide the parts 1, 2, 3 along each other, the free end of the appendix 12 makes contact with the free end of the tooth 14 to prevent any further sliding of the parts along each other, and thus prevent the needle 6 emerging from the plug 8.

It will again be assumqd that the rest conditions of Figure 1 apply, but. that the mouth of a bottle 11 is now inserted into the seat defined by the flexible elements 10. As the bottle mouth i5 inserted in-to said seat, the mouth firstly acts against the protuberances 15 pro~ecting from the elements 10 (so urging these latter outwards), and then acts against the protuberance 13, so bending the appendix 12 outwards. Under these conditions, the parts 1, 2, 3 can be freely slid along each other ~and the needle can perforate and pro~ect below the plug 8) because the appendix 12 is in an outwardly bent state and its free end ~o longer comes into contact with the stop tooth 14. ~hus the presence of the appendix 12 with its protuberance 13 and the presence and positioning a~ the stap tooth 1~ ensure that the needle 6 can be made to praject belaw the plug 8 (and thus be freely extending and accessible from the autside) anly when a medicament bottle mouth or an ob~ect reproducing the shape of such a bottle mouth is housed between the flexible elements 10.

It should be noted that when in the state shown in Figure 2, the protuberances 15 are positloned below the lower edge (relative to the figures) of the mouth of the bottle 11, so preventing its removal from the apparatus as the elements 10 now rest against the ~. ~t free edge of the wall 9 and cannot t~herefore bend outwards.

~he present invention also incorporates the followln~ further characteristic. As stated, when ln the state shown in Flgure 2, the protuberances 15 hook onto and securely retain a bottle mouth.

~ost bottles have a mouth with a proJecting neck of constant defined helght or thickness. There are however bottles with necks of a different height, for e~ample ~rèater than that of the bottle shown by dashed lines ln Figure 2.

In the apparatus described in USA pate~t ~o. 4,576,211 the flexible elements 10 are provided with protuberances able to hook only onto bottles having necks of a defined constant height.

As can be seen from the drawings accompanying this descriptlon, the protuberances 15 are shaped stepwise with the tallest or most proJectin~ step positioned at the ~ree end of the elements 10. In this manner, when the bottle neck is of smaller height, it is hooked by a shorter step on the protuberances 15 (Figure 2), whereas if the bottle neck is of greater height (Figure 3) it is hooked by a taller step on said protuberances.

The apparatus is therefore more versatile -than the known type and can be used with bottles of different structure.

Claims (8)

1. Apparatus for connecting a syringe to a bottle having a lip surrounding a mouth, said apparatus comprising:
(a) a radially inner hollow part having a first end containing a first seat for a syringe and a second end;
(b) an intermediate hollow part slidably received in said radially inner hollow part and having a first open end and a second open end;
(c) a radially outer part slidably received on said intermediate hollow part and having a first end and a second end;
(d) a perforable plug received in said second open end of said intermediate hollow part;
(e) a plurality of flexible retention elements projecting axially from said second open end of said intermediate hollow part radially outwardly of said perforable plug;
~ (f) at least one flexible appendix projecting axially from said second open end of said intermediate hollow part radially outwardly of said performable plug;
(g) at least one stop tooth projecting axially from said second open end of said radially outer part towards said at least one flexible appendix; and (h) means for limiting the axial movement of said parts relative to each other so as to define a first position, in which the overall length of said apparatus is at a maximum, and a second position, in which the overall length of said apparatus is at a minimum, wherein (i) said radially inner hollow part and said first open end of said intermediate part together define a chamber which, in the first position of said apparatus, has an axial length such that, in use, it entirely contains a needle in fluid communication with a syringe received in said first seat and which, in the second position of said apparatus, has an axial length such that, in use, the same needle projects through said perforable plug;
(j) said plurality of flexible retention elements and said second open end of said intermediate hollow part together define a second seat sized, shaped, and positioned to receive and to grip the lip of a bottle; and (k) said at least one flexible appendix is sized, shaped, and positioned so that:
(i) it is cammed radially outwardly when the lip of a bottle is received in said second seat, permitting said apparatus to assume its second position, and (ii) when it is not cammed radially outwardly, it abuts against said at least one stop tooth at a point during the axial movement of said parts relative to each other that prevent said apparatus from assuming its second position.
2. Apparatus as recited in claim 1 wherein said at least one flexible appendix and said at least one stop tooth are sized, shaped, and positioned so that, when said at least one flexible appendix is not cammed radially outwardly, a needle in fluid communication with a syringe received in said first seat cannot project through said perforable plug.
3. Apparatus as recited in claim 1 wherein the needle is rigidly mounted on said radially inner part and, consequently, is a part of said apparatus.
4. Apparatus as recited in claim 1 wherein the needle is rigidly mounted on the syringe and, consequently, is not a part of said apparatus.
5. Apparatus as recited in claim 1 wherein:
(a) a plurality of axially spaced protuberances project radially inwardly from each one of said plurality of flexible retention elements;
(b) the length in the radial direction of said plurality of axially spaced protuberances increases toward said second end of said radially outer part; and (c) the length in the radial direction of each one of said plurality of axially spaced protuberances on each one of said : plurality of flexible retention elements is the same as the length in the radial direction of corresponding ones of said plurality of axially spaced protuberances on the other ones of said plurality of flexible retention elements at the same axial spacing from said intermediate hollow part;
whereby said plurality of flexible retention elements are adapted to grip bottles having lips with different axial lengths.
6. Apparatus for connecting a syringe to a bottle having a lip surrounding a mouth, said apparatus comprising:

(a) a radially inner hollow part having a first end containing a first seat for a syringe and a second end;
(b) an intermediate hollow part slidably received in said radially inner hollow part and having a first open end and a second open end;
(c) a radially outer part slidably received on said intermediate hollow part and having a first end and a second end;
(d) a perforable plug received in said second open end of said intermediate hollow part;
(e) a plurality of flexible retention elements projecting axially from said second open end of said intermediate hollow part radially outwardly of said perforable plug; and (f) means for limiting the axial movement of said parts relative to each other so as to define a first position, in which the overall length of said apparatus is at a maximum, and a second position, in which the overall length of said apparatus is at a minimum, wherein (g) said radially inner hollow part and said first open end of said intermediate hollow part together define a chamber which, in the first position of said apparatus, has an axial length such that, in use, it entirely contains a needle in fluid communication with a syringe received in said first seat and which, in the second position of said apparatus, has an axial length such that, in use, the same needle projects through said perforable plug;
(h) said plurality of flexible retention elements and said second open end of said intermediate hollow part together define a second seat sized, shaped, and positioned to receive and to grip the lip of a bottle; and (i) a plurality of axially spaced protuberances project radially inwardly from each one of said plurality of flexible retention elements;
(j) the length in the radial direction of said plurality of axially spaced protuberances increases towards said second end of said radially outer part; and (k) the length in the radial direction of each one of said plurality of axially spaced protuberances on each one of said plurality of flexible retention elements is the same as the length in the radial direction of corresponding ones of said axially spaced protuberances on the other ones of said plurality of flexible retention elements at the same axial spacing from said intermediate hollow part, whereby said plurality of flexible retention elements are adapted to grip bottles having lips with different axial lengths.
7. Apparatus as recited in claim 6 wherein the needle is rigidly mounted on said radially inner part and, consequently, is a part of said apparatus.

,
8. Apparatus as recited in claim 6 wherein the needle is rigidly mounted on the syringe and, consequently, is not a part of said apparatus.
CA 579849 1987-10-14 1988-10-12 Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament Expired - Fee Related CA1292212C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22283A/87 1987-10-14
IT2228387A IT1231892B (en) 1987-10-14 1987-10-14 APPARATUS WITH SAFETY LOCKING ORGANS FOR CONNECTION OF A SYRINGE TO A BOTTLE CONTAINING A DRUG

Publications (1)

Publication Number Publication Date
CA1292212C true CA1292212C (en) 1991-11-19

Family

ID=11194145

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 579849 Expired - Fee Related CA1292212C (en) 1987-10-14 1988-10-12 Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament

Country Status (19)

Country Link
US (1) US4872494A (en)
EP (1) EP0311787B1 (en)
JP (1) JPH01135354A (en)
KR (1) KR890006265A (en)
AT (1) ATE77046T1 (en)
AU (1) AU603263B2 (en)
CA (1) CA1292212C (en)
DE (1) DE3871899T2 (en)
DK (1) DK569788A (en)
ES (1) ES2032913T3 (en)
FI (1) FI884683A (en)
GR (1) GR3004904T3 (en)
HU (1) HU206990B (en)
IL (1) IL88000A0 (en)
IT (1) IT1231892B (en)
NZ (1) NZ226511A (en)
PT (1) PT88747B (en)
SU (1) SU1746866A4 (en)
ZA (1) ZA887609B (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4986322A (en) * 1987-03-24 1991-01-22 Societe Semco System of packaging for ready to use preparations
US5158558A (en) * 1989-06-26 1992-10-27 University Of Florida Needle-shielding fluid transfer device
US5247972A (en) * 1991-12-17 1993-09-28 Whittier Medical, Inc. Alignment guide for hypodermic syringe
US5279582A (en) * 1992-04-01 1994-01-18 Thomas R Davison Retractable syringe sheath with bottle engagement
US5279583A (en) * 1992-08-28 1994-01-18 Shober Jr Robert C Retractable injection needle assembly
DE4327178C1 (en) * 1993-08-13 1995-03-09 Pms Gmbh Prod & Recycling Device for refilling a printhead of an inkjet printer
US5433256A (en) * 1994-01-14 1995-07-18 Apotex, Inc. Pill guide and dispenser tray
AU703741B2 (en) * 1994-03-21 1999-04-01 Bernd Hansen Device for sterile filling of containers
US5862840A (en) * 1994-03-21 1999-01-26 Hansen; Bernd Device for sterile filling of containers
US5893397A (en) * 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
CA2252404A1 (en) 1996-04-22 1997-10-30 Abbott Laboratories Container closure system
FR2753624B1 (en) * 1996-09-25 1999-04-16 Biodome CONNECTION DEVICE, PARTICULARLY BETWEEN A CONTAINER WITH PERFORABLE CAP AND A SYRINGE
US5924584A (en) * 1997-02-28 1999-07-20 Abbott Laboratories Container closure with a frangible seal and a connector for a fluid transfer device
US5954104A (en) * 1997-02-28 1999-09-21 Abbott Laboratories Container cap assembly having an enclosed penetrator
US5894870A (en) * 1997-06-10 1999-04-20 Pharmacia & Upjohn Company Syringe guide and vial holder
US6159192A (en) 1997-12-04 2000-12-12 Fowles; Thomas A. Sliding reconstitution device with seal
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
AR021220A1 (en) 1998-09-15 2002-07-03 Baxter Int CONNECTION DEVICE FOR ESTABLISHING A FLUID COMMUNICATION BETWEEN A FIRST CONTAINER AND A SECOND CONTAINER.
US6113583A (en) 1998-09-15 2000-09-05 Baxter International Inc. Vial connecting device for a sliding reconstitution device for a diluent container
US8562583B2 (en) 2002-03-26 2013-10-22 Carmel Pharma Ab Method and assembly for fluid transfer and drug containment in an infusion system
US7867215B2 (en) 2002-04-17 2011-01-11 Carmel Pharma Ab Method and device for fluid transfer in an infusion system
SE523001C2 (en) 2002-07-09 2004-03-23 Carmel Pharma Ab Coupling component for transmitting medical substances, comprises connecting mechanism for releasable connection to second coupling component having further channel for creating coupling, where connecting mechanism is thread
US7942861B2 (en) 2002-10-22 2011-05-17 Baxter International Inc. Fluid container with access port and safety cap
US7507226B2 (en) * 2002-10-22 2009-03-24 Baxter International Inc. Access port with safety tab and fluid container employing same
JP4341239B2 (en) 2002-12-19 2009-10-07 ニプロ株式会社 Liquid transfer tool
EP1590024B1 (en) 2003-01-21 2016-04-27 Carmel Pharma AB A needle for penetrating a membrane
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
US7615041B2 (en) * 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
US20070060904A1 (en) * 2005-03-14 2007-03-15 Becton, Dickinson And Company Filling system and method for syringes with short needles
ES2425579T3 (en) 2006-05-25 2013-10-16 Bayer Healthcare, Llc Reconstitution device
US7942860B2 (en) 2007-03-16 2011-05-17 Carmel Pharma Ab Piercing member protection device
ES2542016T3 (en) * 2007-03-16 2015-07-29 Carmel Pharma Ab A drilling member protection device
BRPI0810542A2 (en) * 2007-04-23 2014-10-21 Plastmed Ltd METHOD FOR TRANSFER WITHOUT LIQUID CONTAMINATION, FLUID TRANSFER APPARATUS, EQUIPMENT COUPLING METHOD, CONNECTOR SECTION FOR USE IN A FLUID TRANSFER OPERATION AND CONNECTION SECTION COUPLING METHOD
US7975733B2 (en) 2007-05-08 2011-07-12 Carmel Pharma Ab Fluid transfer device
US8029747B2 (en) 2007-06-13 2011-10-04 Carmel Pharma Ab Pressure equalizing device, receptacle and method
US8622985B2 (en) 2007-06-13 2014-01-07 Carmel Pharma Ab Arrangement for use with a medical device
US8657803B2 (en) 2007-06-13 2014-02-25 Carmel Pharma Ab Device for providing fluid to a receptacle
US10398834B2 (en) 2007-08-30 2019-09-03 Carmel Pharma Ab Device, sealing member and fluid container
US8287513B2 (en) 2007-09-11 2012-10-16 Carmel Pharma Ab Piercing member protection device
JP5329546B2 (en) 2007-09-17 2013-10-30 カルメル ファルマ アクチボラゲット Bag connector
US9039673B2 (en) * 2008-01-09 2015-05-26 Novartis Ag Unitary withdrawal spike unit suitable for factory fitting
FR2928539B1 (en) * 2008-03-12 2012-02-24 Vygon INTERFACING DEVICE FOR PERFORATING BOTTLES FOR THE PREPARATION OF PERFUME FLUIDS
US8414554B2 (en) 2008-05-14 2013-04-09 J & J Solutions, Inc. Systems and methods for safe medicament transport
US8075550B2 (en) 2008-07-01 2011-12-13 Carmel Pharma Ab Piercing member protection device
US8523838B2 (en) 2008-12-15 2013-09-03 Carmel Pharma Ab Connector device
US8790330B2 (en) 2008-12-15 2014-07-29 Carmel Pharma Ab Connection arrangement and method for connecting a medical device to the improved connection arrangement
US8864725B2 (en) 2009-03-17 2014-10-21 Baxter Corporation Englewood Hazardous drug handling system, apparatus and method
US8721614B2 (en) * 2009-10-28 2014-05-13 Terumo Kabushiki Kaisha Connector assembly
US8480646B2 (en) 2009-11-20 2013-07-09 Carmel Pharma Ab Medical device connector
USD637713S1 (en) 2009-11-20 2011-05-10 Carmel Pharma Ab Medical device adaptor
US8162013B2 (en) 2010-05-21 2012-04-24 Tobias Rosenquist Connectors for fluid containers
US9168203B2 (en) 2010-05-21 2015-10-27 Carmel Pharma Ab Connectors for fluid containers
AU2011258371B2 (en) 2010-05-27 2014-09-18 J&J Solutions, Inc. Closed fluid transfer system
US20120000569A1 (en) * 2010-07-01 2012-01-05 Wiegel Christopher D Reservoir filling aid for a medical pump
EP2771060A4 (en) * 2011-10-28 2015-09-02 Ge Healthcare Bio Sciences Probe assembly
MX358074B (en) 2012-02-02 2018-08-03 Becton Dickinson Holdings Pte Ltd Adaptor for coupling with a medical container.
WO2013179596A1 (en) 2012-05-31 2013-12-05 学校法人近畿大学 Exposure-preventing cap
DE102012113002B4 (en) 2012-10-01 2014-04-30 Medac Gesellschaft für klinische Spezialpräparate mbH Transfer device for removing or transferring a fluid
DE102014104281B3 (en) 2014-03-27 2015-09-10 Medac Gesellschaft für klinische Spezialpräparate mbH transfer device
GB201918663D0 (en) * 2019-12-17 2020-01-29 Oribiotech Ltd A connector

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR864605A (en) * 1940-04-02 1941-05-01 Self-cooling impeller
CH581273A5 (en) * 1974-06-04 1976-10-29 Lacrex Brevetti Sa Snap connection between hose ends - has inner and outer sleeves with O-ring seal and finger with ridge and groove
US3993063A (en) * 1975-06-16 1976-11-23 Union Carbide Corporation Protective shielding assembly for use in loading a hypodermic syringe with radioactive material
EP0126718A3 (en) * 1983-05-20 1985-10-23 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
IT1173370B (en) * 1984-02-24 1987-06-24 Erba Farmitalia SAFETY DEVICE TO CONNECT A SYRINGE TO THE MOUTH OF A BOTTLE CONTAINING A DRUG OR A TUBE FOR DISPENSING THE SYRINGE DRUG
US4684365A (en) * 1985-01-24 1987-08-04 Eaton Corporation Disposable refill unit for implanted medication infusion device
IE60235B1 (en) * 1986-09-18 1994-06-15 Kabi Pharmacia Ab "Connector and disposable assembly utilising said connector"
US4768568A (en) * 1987-07-07 1988-09-06 Survival Technology, Inc. Hazardous material vial apparatus providing expansible sealed and filter vented chambers

Also Published As

Publication number Publication date
SU1746866A4 (en) 1992-07-07
GR3004904T3 (en) 1993-04-28
JPH01135354A (en) 1989-05-29
DE3871899T2 (en) 1992-12-10
HU206990B (en) 1993-03-01
EP0311787A3 (en) 1989-10-11
IT8722283A0 (en) 1987-10-14
HUT51905A (en) 1990-06-28
FI884683A (en) 1989-04-15
DK569788A (en) 1989-04-15
AU603263B2 (en) 1990-11-08
AU2361688A (en) 1989-04-20
PT88747B (en) 1993-11-30
ZA887609B (en) 1989-06-28
DE3871899D1 (en) 1992-07-16
US4872494A (en) 1989-10-10
PT88747A (en) 1989-07-31
IT1231892B (en) 1992-01-15
NZ226511A (en) 1991-06-25
ES2032913T3 (en) 1993-03-01
ATE77046T1 (en) 1992-06-15
FI884683A0 (en) 1988-10-12
KR890006265A (en) 1989-06-12
DK569788D0 (en) 1988-10-13
IL88000A0 (en) 1989-06-30
EP0311787A2 (en) 1989-04-19
EP0311787B1 (en) 1992-06-10

Similar Documents

Publication Publication Date Title
CA1292212C (en) Apparatus with safety locking members, for connecting a syringe to a bottle containing a medicament
US5171300A (en) Disposable hypodermic syringe
EP0613382B1 (en) Attachment for a parenteral device
US4576211A (en) Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for drug delivery from the syringe
US4932941A (en) Non-reusable disposable syringe
US5562626A (en) Safety syringe
EP0327061B1 (en) Disposable retractable syringe
EP1377331B1 (en) Non-reusable syringe
JP2954550B2 (en) Connector assembly
US5215524A (en) Plunger for non-reuseable syringe
AU2010202200B2 (en) Single use syringe having safety shield
US4976702A (en) Syringe needle guard
KR960009657B1 (en) Disease control syringe having a retractable needle
US5740909A (en) Lockable and leak-proof sharps disposal container
EP0324009A1 (en) Hazardous material vial apparatus and method
WO1990001962A1 (en) Safety device for an injection syringe needle
WO1993013817A1 (en) Syringe with extendable and retractable needle
EP0300694A1 (en) Non-reusable syringe
EP0758256B1 (en) Hypodermic syringe
MX2013000878A (en) Dual chamber syringe with retractable needle.
US20050054979A1 (en) Syringe
JPH05503458A (en) Protection mechanism for syringe
US5380297A (en) Syringe
EP1287842B1 (en) Safety device for a safety syringe
MXPA01008884A (en) Retracting needle syringe.

Legal Events

Date Code Title Description
MKLA Lapsed