CA1326425C - Dilatation catheter with a microporous permeable balloon - Google Patents
Dilatation catheter with a microporous permeable balloonInfo
- Publication number
- CA1326425C CA1326425C CA000596954A CA596954A CA1326425C CA 1326425 C CA1326425 C CA 1326425C CA 000596954 A CA000596954 A CA 000596954A CA 596954 A CA596954 A CA 596954A CA 1326425 C CA1326425 C CA 1326425C
- Authority
- CA
- Canada
- Prior art keywords
- dilatation element
- fluid
- lumen
- tissue
- dilatation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0475—Tracheal tubes having openings in the tube
- A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
- A61M16/0481—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids through the cuff wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1079—Balloon catheters with special features or adapted for special applications having radio-opaque markers in the region of the balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
Abstract
Abstract A catheter for treating a constricted blood vessel (10) comprises an elongated tubular body (3) having an internal lumen (4), a proximal portion and a distal portion, and includes an inflatable dilatation element (1) on the distal portion thereof.
The dilatation element is in communication (9) with the lumen and is adapted to be inflatable and deflatable by the application of a suitable therapeutic tissue dissolving fluid (13) pressurized within the lumen. The dilatation element includes a wall (5) having microporus openings (12) adapted to be permeable by the fluid applied to inflate the dilatation element. The fluid, which is pumped into the interior space of the dilatation element, under sufficient pressure, presses through the microporus wall directly on and into the adjacent tissue (11).
The fluid tends to dissolve the tissue, thereby treatment time is considerably shortened and the long-term success of the treatment is improved, since the impairing tissue is not only dislodged but also dissolved from the vessel.
The dilatation element is in communication (9) with the lumen and is adapted to be inflatable and deflatable by the application of a suitable therapeutic tissue dissolving fluid (13) pressurized within the lumen. The dilatation element includes a wall (5) having microporus openings (12) adapted to be permeable by the fluid applied to inflate the dilatation element. The fluid, which is pumped into the interior space of the dilatation element, under sufficient pressure, presses through the microporus wall directly on and into the adjacent tissue (11).
The fluid tends to dissolve the tissue, thereby treatment time is considerably shortened and the long-term success of the treatment is improved, since the impairing tissue is not only dislodged but also dissolved from the vessel.
Description
13~2~
P.C. 7393 CATHETER FOR RECANALIZING CONSTRICTED VESSELS
The invention relates to a dilatation catheter for treating a constrictPd blood vessel. Dilatation catheters have been employed fGr some time in the treatment of vascular constrictions generally known as angioplasty. Such catheters have an elongated tubular body with a balloon at the distal end that is inflatable and deflatable under fluid pressure. A
guide wire is typically first inserted within the vessel to the location of the constriction. ~he catheter is then inserted (with the balloon deflated) over the guide wire with the balloon positioned at the location of the constriction. By way of an externally accessible internal lumen leading through the support tube, the balloon is filled with fluid, so that it expands causing the constricting tissue to be pressed outwardly into the vessel wall.
A disadvantage of the angioplasty procedure is that the treatment of severe constrictions takes a comparatively long time and can require periodic interruption in order to avoid distal ischemia. It has also been found that the treatment is sometimes unsuccessful because the constricting tissue is not removed but merely pressed to the wall of the vessel and restenosis can eventually occur. The success of such a treatment can be improved if a substance that will dissolve the impairing tissue, as for example a plasminogen activator, is introduced into the vessel to be treated.
It is an ob;ect of the present invention to provide a dilatation catheter in which vascular constrictions can be treated with a suitable therapeutic (tissue dissolving) fluid resulting in greater long-term success.
, . ..
~2- ~3~2~
This object is achieved by the present invention in which a catheter for treating a constricted blood vessel comprises an elongated tubular body having an internal lumen, a proximal portion and a distal portion, and includes an inflatable dilatation element on the distal portion thereof. The dilatation element is in communication with the lumen and is adapted to be inflatable and deflatable by the application of a suitable tissue dissolving fluid pressurized within the lumen. The dilatation element includes a wall having microporus openings adapted to be permeable by the fluid applied to inflate the dilatation element. The fluid, which is pumped into the interior space of the dilatation element, under sufficient pressure, presses through the microporus wall directly on and into the adjacent ti~sue. The fluid tends to dissolve the tissue, thereby treatment time is considerably shortened and the long-term success of the treatment is improved, since the impairing tissue is not only dislodged but also dissolved from the vessel. The fluid has a rapid and focused effect because it is brought directly to the action site and thereby requires only a minimal quantity of the therapeutic fluid.
The invention will be better understood from the following detailed description taken in conjunction with the drawing.
Fig. 1 shows a longitudinal section of the catheter of the present invention in the distended state;
Fig. la is a sectional view taken along the line I-I of Figure 1:
Fig. 2 shows a longitudinal section of a blood vessel having the catheter of Figure 1 inserted therein: and -3- ~3~2~
Fig. 3 is a sectional view taken along the line III-III of Fig. 2.
Referring to the figures, the catheter of the present invention is illustrated, by an example, in which an elongated tubular body 3 has a dilatation balloon 1 attached to the distal end thereof. The interior of the dilatation balloon is in communication with an internal lumen 4 through an opening 9 of a connecting piece 6. The lumen 4 is accessible at the proximal portion of the body to inflate and deflate the balloon with a suitable fluid respectively by a typical suction and pressure pump (not shown).
The dilatation balloon 1 is deflated into a compressed or folded state for the purpose of introduction into a blood vessel. For such introduction of the dilatation balloon 1, a stenosed section of vessel (see Figure 3) is first probed utilizing a well-known technique by a guide wire 2 and the catheter and the dilatation balloon 1 is then inserted onto the guide wire 2 and extended to the section of vessel to be dilated. Radiopaque marking elements 8 are mounted on a tubing piece 7 and are clearly visible on x-ray to facilitate the proper location of the balloon.
When the dilatation balloon 1 is in the desired location of the vessel, it is filled with a suitable therapeutic fluid 13 under controlled pressure by means of a pressure pump, until it assumes the cylindrical shape. The dilatation balloon 1 is designed so that after reaching a determined shape, it will not assume a larger diameter even when considerably greater pressure is exerted. This prevents the vessel from being inadvertently excessively distended and damaged.
The dilatation balloon 1 is formed for example, of polyvinyl chloride and has, a cylindrical wall 5 .
_4_ 1 3 2 ~
provided with microporus openings 12. The openings 12 are preferably arranged evenly in the radial and longitudinal surface so that in the dilated state, the fluid 13 presses uniformly radially outwardly through the wall 5. The openings 12 have a comparatively small diameter, for example O.05 mm, so that the wall 5 is microporus yet permeable to the fluid 13.
In Figs. 2 and 3, the constriction is schematically illustrated as a tissue 11 forming a stenosis in vessel 10. In the dilated state, the outer surface of the wall 5 lies adjacent to the tissue 11 and the fluid 13 is forced into the tissue 11 through the openings 12. The fluid 13 is thus delivered directly to the tissue 11.
The openings 12 are uniformly distributed on the wall 5 at approximately the same intervals, in order to ensure a suitably uniform and distributed delivery of the fluid 13 to the tissue 11.
The fluid 13 contains a suitable therapeutic agent and/or contrast medium. In the case of treatment of a stenosis the therapeutic agent is specifically a drug which dissolves the tissue 11.
Such drugs are known for example as plasminogen activator. During treatment the vasoconstrictive tissue 11 is pressed onto the vascular wall 10 and simultaneously a specified amount of the therapeutic fluid is introduced under pressure directly into the tissue 11. The constricting tissue 11 can thus be eliminated in a fast and gentle manner.
P.C. 7393 CATHETER FOR RECANALIZING CONSTRICTED VESSELS
The invention relates to a dilatation catheter for treating a constrictPd blood vessel. Dilatation catheters have been employed fGr some time in the treatment of vascular constrictions generally known as angioplasty. Such catheters have an elongated tubular body with a balloon at the distal end that is inflatable and deflatable under fluid pressure. A
guide wire is typically first inserted within the vessel to the location of the constriction. ~he catheter is then inserted (with the balloon deflated) over the guide wire with the balloon positioned at the location of the constriction. By way of an externally accessible internal lumen leading through the support tube, the balloon is filled with fluid, so that it expands causing the constricting tissue to be pressed outwardly into the vessel wall.
A disadvantage of the angioplasty procedure is that the treatment of severe constrictions takes a comparatively long time and can require periodic interruption in order to avoid distal ischemia. It has also been found that the treatment is sometimes unsuccessful because the constricting tissue is not removed but merely pressed to the wall of the vessel and restenosis can eventually occur. The success of such a treatment can be improved if a substance that will dissolve the impairing tissue, as for example a plasminogen activator, is introduced into the vessel to be treated.
It is an ob;ect of the present invention to provide a dilatation catheter in which vascular constrictions can be treated with a suitable therapeutic (tissue dissolving) fluid resulting in greater long-term success.
, . ..
~2- ~3~2~
This object is achieved by the present invention in which a catheter for treating a constricted blood vessel comprises an elongated tubular body having an internal lumen, a proximal portion and a distal portion, and includes an inflatable dilatation element on the distal portion thereof. The dilatation element is in communication with the lumen and is adapted to be inflatable and deflatable by the application of a suitable tissue dissolving fluid pressurized within the lumen. The dilatation element includes a wall having microporus openings adapted to be permeable by the fluid applied to inflate the dilatation element. The fluid, which is pumped into the interior space of the dilatation element, under sufficient pressure, presses through the microporus wall directly on and into the adjacent ti~sue. The fluid tends to dissolve the tissue, thereby treatment time is considerably shortened and the long-term success of the treatment is improved, since the impairing tissue is not only dislodged but also dissolved from the vessel. The fluid has a rapid and focused effect because it is brought directly to the action site and thereby requires only a minimal quantity of the therapeutic fluid.
The invention will be better understood from the following detailed description taken in conjunction with the drawing.
Fig. 1 shows a longitudinal section of the catheter of the present invention in the distended state;
Fig. la is a sectional view taken along the line I-I of Figure 1:
Fig. 2 shows a longitudinal section of a blood vessel having the catheter of Figure 1 inserted therein: and -3- ~3~2~
Fig. 3 is a sectional view taken along the line III-III of Fig. 2.
Referring to the figures, the catheter of the present invention is illustrated, by an example, in which an elongated tubular body 3 has a dilatation balloon 1 attached to the distal end thereof. The interior of the dilatation balloon is in communication with an internal lumen 4 through an opening 9 of a connecting piece 6. The lumen 4 is accessible at the proximal portion of the body to inflate and deflate the balloon with a suitable fluid respectively by a typical suction and pressure pump (not shown).
The dilatation balloon 1 is deflated into a compressed or folded state for the purpose of introduction into a blood vessel. For such introduction of the dilatation balloon 1, a stenosed section of vessel (see Figure 3) is first probed utilizing a well-known technique by a guide wire 2 and the catheter and the dilatation balloon 1 is then inserted onto the guide wire 2 and extended to the section of vessel to be dilated. Radiopaque marking elements 8 are mounted on a tubing piece 7 and are clearly visible on x-ray to facilitate the proper location of the balloon.
When the dilatation balloon 1 is in the desired location of the vessel, it is filled with a suitable therapeutic fluid 13 under controlled pressure by means of a pressure pump, until it assumes the cylindrical shape. The dilatation balloon 1 is designed so that after reaching a determined shape, it will not assume a larger diameter even when considerably greater pressure is exerted. This prevents the vessel from being inadvertently excessively distended and damaged.
The dilatation balloon 1 is formed for example, of polyvinyl chloride and has, a cylindrical wall 5 .
_4_ 1 3 2 ~
provided with microporus openings 12. The openings 12 are preferably arranged evenly in the radial and longitudinal surface so that in the dilated state, the fluid 13 presses uniformly radially outwardly through the wall 5. The openings 12 have a comparatively small diameter, for example O.05 mm, so that the wall 5 is microporus yet permeable to the fluid 13.
In Figs. 2 and 3, the constriction is schematically illustrated as a tissue 11 forming a stenosis in vessel 10. In the dilated state, the outer surface of the wall 5 lies adjacent to the tissue 11 and the fluid 13 is forced into the tissue 11 through the openings 12. The fluid 13 is thus delivered directly to the tissue 11.
The openings 12 are uniformly distributed on the wall 5 at approximately the same intervals, in order to ensure a suitably uniform and distributed delivery of the fluid 13 to the tissue 11.
The fluid 13 contains a suitable therapeutic agent and/or contrast medium. In the case of treatment of a stenosis the therapeutic agent is specifically a drug which dissolves the tissue 11.
Such drugs are known for example as plasminogen activator. During treatment the vasoconstrictive tissue 11 is pressed onto the vascular wall 10 and simultaneously a specified amount of the therapeutic fluid is introduced under pressure directly into the tissue 11. The constricting tissue 11 can thus be eliminated in a fast and gentle manner.
Claims (7)
1. A catheter for treating a constricted blood vessel comprising an elongated tubular body having an internal lumen, a proximal portion and a distal portion, and including an inflatable dilatation element on the distal portion thereof which is in communication with said lumen and which is adapted to be inflatable and deflatable by the application of a pressurized fluid within said lumen;
characterized in that said dilatation element includes a wall having microporus openings adapted to be permeable by the fluid applied to inflate said dilatation element.
characterized in that said dilatation element includes a wall having microporus openings adapted to be permeable by the fluid applied to inflate said dilatation element.
2. A catheter according to claim 1, wherein said dilatation element comprises a tubular balloon having a substantially cylindrical wall when inflated.
3. A catheter according to claim 2 which said microporous openings are arranged radially.
4. A catheter according to claim 2 wherein said microporous openings are distributed substantially uniformly along the cylindrical wall.
5. A catheter according to claim 2 wherein said microporous openings are approximately 0.05 mm in diameter.
6. A catheter according to claim 2 wherein said elongated tubular body further includes a second lumen adapted to receive a guide wire.
7. A catheter according to claim 5 wherein said dilatation element is formed of polyvinyl chloride.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH146088 | 1988-04-20 | ||
| CH1460/88-1 | 1988-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1326425C true CA1326425C (en) | 1994-01-25 |
Family
ID=4210991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000596954A Expired - Fee Related CA1326425C (en) | 1988-04-20 | 1989-04-18 | Dilatation catheter with a microporous permeable balloon |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5098381A (en) |
| EP (1) | EP0338979B1 (en) |
| JP (1) | JPH062157B2 (en) |
| AT (1) | ATE79040T1 (en) |
| AU (1) | AU621870B2 (en) |
| CA (1) | CA1326425C (en) |
| DE (2) | DE8904026U1 (en) |
| ES (1) | ES2034749T3 (en) |
| GR (1) | GR3005636T3 (en) |
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| US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
| US4423725A (en) * | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
| US4662368A (en) | 1983-06-13 | 1987-05-05 | Trimedyne Laser Systems, Inc. | Localized heat applying medical device |
| US4585000A (en) * | 1983-09-28 | 1986-04-29 | Cordis Corporation | Expandable device for treating intravascular stenosis |
| DE3442736A1 (en) * | 1984-11-23 | 1986-06-05 | Tassilo Dr.med. 7800 Freiburg Bonzel | DILATATION CATHETER |
| US4616648A (en) | 1985-01-08 | 1986-10-14 | Devices For Vascular Intervention | Device facilitating the exchange of dilatation catheters during an angioplasty procedure |
| US4824436A (en) * | 1985-04-09 | 1989-04-25 | Harvey Wolinsky | Method for the prevention of restenosis |
| DE3821544C2 (en) * | 1988-06-25 | 1994-04-28 | H Prof Dr Med Just | Dilatation catheter |
| US4994033A (en) * | 1989-05-25 | 1991-02-19 | Schneider (Usa) Inc. | Intravascular drug delivery dilatation catheter |
-
1989
- 1989-04-01 DE DE8904026U patent/DE8904026U1/de not_active Expired
- 1989-04-04 AT AT89810248T patent/ATE79040T1/en not_active IP Right Cessation
- 1989-04-04 DE DE8989810248T patent/DE58901964D1/en not_active Expired - Fee Related
- 1989-04-04 EP EP89810248A patent/EP0338979B1/en not_active Expired - Lifetime
- 1989-04-04 ES ES198989810248T patent/ES2034749T3/en not_active Expired - Lifetime
- 1989-04-18 CA CA000596954A patent/CA1326425C/en not_active Expired - Fee Related
- 1989-04-19 AU AU33193/89A patent/AU621870B2/en not_active Ceased
- 1989-04-20 JP JP1101512A patent/JPH062157B2/en not_active Expired - Fee Related
-
1991
- 1991-07-19 US US07/732,953 patent/US5098381A/en not_active Expired - Lifetime
-
1992
- 1992-09-07 GR GR920401966T patent/GR3005636T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE8904026U1 (en) | 1989-05-24 |
| AU3319389A (en) | 1989-10-26 |
| ES2034749T3 (en) | 1993-04-01 |
| DE58901964D1 (en) | 1992-09-10 |
| JPH062157B2 (en) | 1994-01-12 |
| EP0338979B1 (en) | 1992-08-05 |
| EP0338979A3 (en) | 1990-01-10 |
| AU621870B2 (en) | 1992-03-26 |
| US5098381A (en) | 1992-03-24 |
| ATE79040T1 (en) | 1992-08-15 |
| EP0338979A2 (en) | 1989-10-25 |
| GR3005636T3 (en) | 1993-06-07 |
| JPH0213464A (en) | 1990-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |