CA2008739A1 - Compositions and method for the treatment of disease - Google Patents
Compositions and method for the treatment of diseaseInfo
- Publication number
- CA2008739A1 CA2008739A1 CA2008739A CA2008739A CA2008739A1 CA 2008739 A1 CA2008739 A1 CA 2008739A1 CA 2008739 A CA2008739 A CA 2008739A CA 2008739 A CA2008739 A CA 2008739A CA 2008739 A1 CA2008739 A1 CA 2008739A1
- Authority
- CA
- Canada
- Prior art keywords
- compositions
- disease
- treatment
- arylpropionic
- implicated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Synergistic compositions comprising an antioxidant and an arylpropionic, non-steroidal anti-inflammatory drug used to treat certain diseases are disclosed. The compositions inhibit production of arachidonic acid cascade end-products which have been implicated as causes of tissue-destruction in periodontal disease. The compositions are administered in combination with a carrier, which may be a mucosal-tenacious polymer selected from the groups of semi-solid pastes, gels, ointments, liquids or films.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/302,210 US5032384A (en) | 1989-01-27 | 1989-01-27 | Compositions and method for the treatment of disease |
US302,210 | 1989-01-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2008739A1 true CA2008739A1 (en) | 1990-07-27 |
CA2008739C CA2008739C (en) | 1998-06-23 |
Family
ID=23166770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002008739A Expired - Lifetime CA2008739C (en) | 1989-01-27 | 1990-01-26 | Compositions and method for the treatment of disease |
Country Status (10)
Country | Link |
---|---|
US (1) | US5032384A (en) |
EP (1) | EP0380367B1 (en) |
JP (1) | JP2764451B2 (en) |
AT (1) | ATE97805T1 (en) |
AU (1) | AU622756B2 (en) |
CA (1) | CA2008739C (en) |
DE (1) | DE69004817T2 (en) |
DK (1) | DK0380367T3 (en) |
ES (1) | ES2060014T3 (en) |
NZ (1) | NZ232250A (en) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
US5188817A (en) * | 1989-03-27 | 1993-02-23 | Julius Ozick | Method of treatment for periodontitis |
JPH02258718A (en) * | 1989-03-31 | 1990-10-19 | Nippon Kayaku Co Ltd | Pasty base and pharmaceutical |
CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
US5464609A (en) * | 1990-03-16 | 1995-11-07 | The Procter & Gamble Company | Use of ketorolac for treatment of oral diseases and conditions |
AU661818B2 (en) * | 1990-03-16 | 1995-08-10 | Procter & Gamble Company, The | Use of ketorolac for treatment of periodontal disease |
CA2061477A1 (en) * | 1991-03-25 | 1992-09-26 | Lawrence J. Daher | Analgesic composition containing beta-carotene |
US5605930A (en) * | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
CA2134073A1 (en) * | 1992-04-23 | 1993-11-11 | Ze'ev Shaked | Bioadhesive aqueous mineral oil emulsion ointment base, topical pharmaceutical compositions comprising same and their use in wound healing |
US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
FR2698788B1 (en) * | 1992-12-09 | 1995-03-03 | Union Pharma Scient Appl | Effervescent pharmaceutical composition containing ibuprofen and process for its preparation. |
AU6582194A (en) * | 1993-04-27 | 1994-11-21 | Sunstar Inc. | Intraoral composition |
FR2710265B1 (en) * | 1993-09-22 | 1995-10-20 | Adir | Bioadhesive pharmaceutical composition for the controlled release of active ingredients. |
US5897858A (en) * | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
US5462728A (en) * | 1994-04-05 | 1995-10-31 | Blank; Izhak | Pharmaceutical compositions |
CN1129400A (en) * | 1994-05-06 | 1996-08-21 | 阿尔康实验室公司 | Use of vitamin E. Tocopheryl derivatives in ophthalmic compositions |
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5607966A (en) * | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
US5811453A (en) * | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Viscoelastic compositions and methods of use |
NZ311474A (en) * | 1995-06-09 | 1997-09-22 | Euro Celtique Sa | Formulations for providing prolonged local anesthesia |
FR2742054B1 (en) * | 1995-12-06 | 1998-01-09 | Synthelabo | PHARMACEUTICAL COMPOSITIONS CONTAINING AN ANTI-INFLAMMATORY AGENT AND VEGETABLE CERAMIDES |
JPH11511763A (en) | 1996-06-24 | 1999-10-12 | ユーロ―セルティーク,エス.エイ. | How to provide safe local anesthesia |
US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5827886A (en) * | 1997-05-07 | 1998-10-27 | Thione International, Inc. | Composition for relief of arthritis-induced symptoms |
EP1009390A4 (en) * | 1997-07-02 | 2004-05-06 | Euro Celtique Sa | Prolonged anesthesia in joints and body spaces |
US6138683A (en) * | 1997-09-19 | 2000-10-31 | Thione International, Inc. | Smokeless tobacco products containing antioxidants |
US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
US6228347B1 (en) * | 1997-12-01 | 2001-05-08 | Thione International, Inc. | Antioxidant gel for gingival conditions |
JP3763075B2 (en) * | 1998-04-24 | 2006-04-05 | サンスター株式会社 | Food composition, oral composition and pharmaceutical composition for prevention or treatment of periodontal disease |
ITMI981586A1 (en) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | VITAMIN AND ITS ESTERS FOR USE IN TOPICAL TREATMENT OF MUCOSA DISORDERS |
FR2781156B1 (en) * | 1998-07-20 | 2001-06-29 | Lafon Labor | PHARMACEUTICAL COMPOSITION FOR PARTICULARLY FOR THE PREVENTION AND TREATMENT OF RADIOMUCITES AND CHEMOMUCITES |
US6254891B1 (en) | 1998-09-03 | 2001-07-03 | Ascent Pediatrics, Inc. | Extended release acetaminophen |
US6126967A (en) * | 1998-09-03 | 2000-10-03 | Ascent Pediatrics | Extended release acetaminophen particles |
US6201028B1 (en) | 1998-12-08 | 2001-03-13 | The Rockefeller University | Methods and compositions for prevention and treatment of atherosclerosis and hyperlipidemia with non-steroidal anti-inflammatory drugs |
US6200550B1 (en) | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
KR19990068298A (en) * | 1999-03-12 | 1999-09-06 | 정명우 | Tooth paste-composition containing rose-seed oil |
US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US20030158111A1 (en) * | 1999-10-01 | 2003-08-21 | David Bar-Or | Methods and products for oral care |
US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
JP4886107B2 (en) * | 2000-10-13 | 2012-02-29 | サンスター株式会社 | Oral dissolving tablets for periodontal disease prevention |
JP2004521111A (en) * | 2001-01-25 | 2004-07-15 | ユーロ−セルティーク,エス.エイ. | Local anesthetics and usage |
JP4803889B2 (en) * | 2001-03-01 | 2011-10-26 | 日本ゼトック株式会社 | Non-aqueous toothpaste |
FR2832630B1 (en) * | 2001-11-28 | 2005-01-14 | Oreal | COSMETIC AND / OR DERMATOLOGICAL COMPOSITION CONTAINING AT LEAST ONE OXIDATION-SENSITIVE HYDROPHILIC ACTIVE STABILIZED WITH AT LEAST ONE COPOLYMER OF N-VINYLIMIDAZOLE |
DE10163543A1 (en) * | 2001-12-21 | 2003-07-31 | Basf Ag | Super absorber containing tocopherol |
DE10224612A1 (en) * | 2002-06-04 | 2003-12-24 | Lohmann Therapie Syst Lts | Active substance-containing film-like preparations with improved chemical stability, and process for their preparation |
ES2254885T3 (en) * | 2002-06-20 | 2006-06-16 | L'oreal | COSMETIC AND / OR DERMATOLOGICAL USE OF A COMPOSITION THAT CONTAINS AT LEAST A HYDROPHYLE AGENT SENSITIVE TO OXIDATION FOR AT LEAST ONE MALEIC ANHYDRID COPOLYMER. |
EP1545452A1 (en) * | 2002-09-28 | 2005-06-29 | McNEIL-PPC, INC. | Modified release dosage forms |
JP4495901B2 (en) * | 2002-10-02 | 2010-07-07 | 日本澱粉工業株式会社 | Active inhibitor for oral preparation |
CN102266272B (en) | 2002-11-27 | 2012-12-26 | Dmi生物科学公司 | Personal care composition and products |
WO2004100884A2 (en) * | 2003-05-07 | 2004-11-25 | Dmi Biosciences, Inc. | Oral care methods and products |
AU2004275821A1 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize N-acyl-L-aspartic acid |
KR100564934B1 (en) * | 2003-12-09 | 2006-03-30 | 학교법인 건국대학교 | method for manufacturing an edible film including polyphenol extracted from green tea |
US8168161B2 (en) * | 2004-12-22 | 2012-05-01 | Hill's Pet Nutrition, Inc. | Method to promote oral health in companion animals |
CN101404990B (en) * | 2006-03-16 | 2012-04-25 | 诺瓦提斯公司 | Solid dosage form containing a taste masked active agent |
JP2009269851A (en) * | 2008-05-07 | 2009-11-19 | Nikko Chemical Co Ltd | Inhibitor of prostaglandin e2 production and its utilization |
US8956161B2 (en) | 2008-11-04 | 2015-02-17 | Duane C Keller | Article and method for controlling oral-originated systemic disease |
US8905760B2 (en) * | 2008-11-04 | 2014-12-09 | Duane C. Keller | Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations |
TWI435733B (en) * | 2010-01-29 | 2014-05-01 | Colgate Palmolive Co | Oral care formulations for malodor control |
US8591229B2 (en) | 2010-12-16 | 2013-11-26 | Duane C. Keller | Devices and methods for creating a positive pressure environment for treatment of oral biofilms associated with periodontal disease |
RU2763874C1 (en) * | 2021-05-04 | 2022-01-11 | Светлана Николаевна Саблина | Method for the treatment of inflammatory periodontal diseases in women in the menopausal and postmenopausal periods |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411885A (en) * | 1980-09-30 | 1983-10-25 | Barels Ronald R | Vitamin E oil based dentifrice |
JPS57139013A (en) * | 1981-02-19 | 1982-08-27 | Eisai Co Ltd | Prophylactic or remedy for periodontosis |
AU556817B2 (en) * | 1982-02-03 | 1986-11-20 | Efamol Limited | Topical application of a lithium salt and dihomo-alpha- linolenic acid |
CH655656B (en) * | 1982-10-07 | 1986-05-15 | ||
JPS59122422A (en) * | 1982-12-29 | 1984-07-14 | Toko Yakuhin Kogyo Kk | Anti-inflammatory analgesic gel for oral cavity |
JPS59222406A (en) * | 1983-06-01 | 1984-12-14 | Teijin Ltd | Pharmaceutical preparation for remedying periodontosis and its preparation |
US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
DE3346525A1 (en) * | 1983-12-22 | 1985-07-04 | A. Nattermann & Cie GmbH, 5000 Köln | PHARMACEUTICAL PREPARATION WITH SPECIAL 1,2-DIACYL-GLYCERO-3-PHOSPHOCHOLINES FOR THE TREATMENT OF DISEASES IN THE GASTIC COLON |
JPH0647533B2 (en) * | 1984-08-10 | 1994-06-22 | 裕 水島 | Fat emulsion containing 4-biphenylylacetic acid compound |
EP0187703B1 (en) * | 1985-01-11 | 1992-08-05 | Teijin Limited | Sustained release preparation |
ATE46265T1 (en) * | 1985-01-23 | 1989-09-15 | Asta Pharma Ag | SYNERGISTIC COMBINATION OF FLUPIRTIN AND NON-STEROIDAL ANTIPHLOGISTICS. |
GB8507058D0 (en) * | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
DE3681754D1 (en) * | 1985-04-27 | 1991-11-07 | Nitto Denko Corp | ADHESIVE PLASTER AND MEDICINAL PRODUCTS FOR THE MOUTH. |
DE3676235D1 (en) * | 1985-06-04 | 1991-01-31 | Teijin Ltd | DRUG PREPARATION WITH DELAYED DELIVERY OF ACTIVE SUBSTANCE. |
JPH0676314B2 (en) * | 1985-09-30 | 1994-09-28 | 花王株式会社 | Suppository base and suppository |
JPS62223115A (en) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | Remedy for periodontosis |
JPS62223112A (en) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | Remedy for periodontosis |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
JPH0744940B2 (en) * | 1986-12-24 | 1995-05-17 | ライオン株式会社 | Base material for oral application |
EP0279867A3 (en) * | 1987-01-12 | 1988-10-05 | EFEKA Friedrich & Kaufmann GmbH & Co KG | Use of vitamin e and combinations of vitamin e with anti-inflammatory agents and analgesics in the treatment of rheumatic diseases |
US4847069A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
US4954332A (en) * | 1987-10-22 | 1990-09-04 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
US4869897A (en) * | 1987-10-22 | 1989-09-26 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid |
US4847072A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate |
US4847071A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
US4946671A (en) * | 1987-10-22 | 1990-08-07 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
US4939135A (en) * | 1988-10-03 | 1990-07-03 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
-
1989
- 1989-01-27 US US07/302,210 patent/US5032384A/en not_active Expired - Lifetime
-
1990
- 1990-01-24 AU AU48761/90A patent/AU622756B2/en not_active Expired
- 1990-01-25 NZ NZ232250A patent/NZ232250A/en unknown
- 1990-01-26 JP JP2017688A patent/JP2764451B2/en not_active Expired - Lifetime
- 1990-01-26 DK DK90300855.5T patent/DK0380367T3/en active
- 1990-01-26 CA CA002008739A patent/CA2008739C/en not_active Expired - Lifetime
- 1990-01-26 DE DE90300855T patent/DE69004817T2/en not_active Expired - Lifetime
- 1990-01-26 EP EP90300855A patent/EP0380367B1/en not_active Expired - Lifetime
- 1990-01-26 ES ES90300855T patent/ES2060014T3/en not_active Expired - Lifetime
- 1990-01-26 AT AT90300855T patent/ATE97805T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU622756B2 (en) | 1992-04-16 |
DE69004817D1 (en) | 1994-01-13 |
NZ232250A (en) | 1991-04-26 |
JP2764451B2 (en) | 1998-06-11 |
DK0380367T3 (en) | 1994-02-28 |
AU4876190A (en) | 1990-08-09 |
DE69004817T2 (en) | 1994-04-14 |
US5032384A (en) | 1991-07-16 |
JPH02270815A (en) | 1990-11-05 |
ES2060014T3 (en) | 1994-11-16 |
ATE97805T1 (en) | 1993-12-15 |
CA2008739C (en) | 1998-06-23 |
EP0380367A1 (en) | 1990-08-01 |
EP0380367B1 (en) | 1993-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry | ||
MKEX | Expiry |
Effective date: 20100126 |