CA2013814A1 - Device for cardiac defibrillation - Google Patents

Device for cardiac defibrillation

Info

Publication number
CA2013814A1
CA2013814A1 CA002013814A CA2013814A CA2013814A1 CA 2013814 A1 CA2013814 A1 CA 2013814A1 CA 002013814 A CA002013814 A CA 002013814A CA 2013814 A CA2013814 A CA 2013814A CA 2013814 A1 CA2013814 A1 CA 2013814A1
Authority
CA
Canada
Prior art keywords
arrhythmia
progress
still
charging
shock
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002013814A
Other languages
French (fr)
Inventor
Benjamin Pless
Phillip L. Ball
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacesetter Inc
Original Assignee
Benjamin Pless
Ventritex, Inc.
Phillip L. Ball
Pacesetter, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benjamin Pless, Ventritex, Inc., Phillip L. Ball, Pacesetter, Inc. filed Critical Benjamin Pless
Publication of CA2013814A1 publication Critical patent/CA2013814A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39Heart defibrillators
    • A61N1/3956Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
    • A61N1/3962Implantable devices for applying electric shocks to the heart, e.g. for cardioversion in combination with another heart therapy
    • A61N1/39622Pacing therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39Heart defibrillators
    • A61N1/3987Heart defibrillators characterised by the timing or triggering of the shock

Abstract

DEVICE FOR CARDIAC DEFIBRILLATION
ABSTRACT OF THE DISCLOSURE
A method for cardiac defibrillation is described, for use with an implanted defibrillator. A
patient's R-waves are sensed to detect the R-R intervals.
If an arrhythmia is detected, the charging of a capacitor is commenced. Determinations are made whether the arrhythmia is still in progress and whether the capacitor is charged a predetermined amount. If the arrhythmia is not still in progress, the charging is discontinued. If the arrhythmia is still in progress and the capacitors are charged a predetermined amount, another R-R interval is detected and if the R-R interval is shorter than a selected amount, a shock is delivered to the heart.

Description

3 ~

Docket Mo. 13436 DEVICE FOR CARDIAC DE~IBRILLATION

FIELD OF THE INYENTION

The present invention concerns a novel device for safely defibrillating the heart including an implanted cardiac de~ibrillator.

BACKGROUND OF THE INVENTION

Implanted cardiac defibrillators are known, in which the high voltage capacitors are discharged to provide a defibrillating high energy shock that is timed off the sensed electrogram. However, if there is a mistaken diagnosis by the device and the shock is delivered into sinus, it is particularly arrhythmogenic if it is asynchronous and happens to coincide with the vulnerable zone. Further, if the rhythm converts back to sinus rhythm, we have found that the shock should be aborted since even a synchronous shock carries some risk.
Present implantable defibrillators that are sold by CPI/Intec are committed to deliver a high voltage shock once the capacitors begin charging. Thus after charging is completed, the high voltage shock will necessarily be delivered. Likewise, the implantable cardioverter that was sold by Medtronic, Inc. was also committed to deliver the high voltage shock once the capacitors begin charging.
In the implantable defibrlllator presently sold by Telectronlcs, Inc., during charglng of the capacltors the charging is discontinued part way to recheck the arrhythmia status. However, independent of the result of that arrhythmia check, the capacltors continue charging and an arrhythmla check is made again when the capacitors are fully charged. Only if both checks show an arrhythmia, do the capacitors deliver the high voltage shock to the heart.
It is an object of the invention to provide a cardiac defibrillation device in which the high voltage shock does not coincide with the vulnerable zone.
Another object of the present inven~ion is to provide a cardiac defibrillation device in which the high voltage shock is aborted if the arrhythmia converts back to sinus rhythm.
Other objects and advantages of the invention will become apparen-t as the description proceeds.

SVMM~RY OF TH~ INVENTION

In accordance with the present invention, a device is provided for cardiac defibrillation including an implantable defibrillator having means for sensing R-~3~

waves, energy storage means, charging means anddischarging means for delivering a shock to the heart.
The device of the present invention comprises means for:
sensing a patient's R~waves to detect R-R intervals; if an arrhythmia is detected, then commencing charging of the storage means; determining whether the arrhythmia is still in progress; if the arrhythmia is still in progress, then determining if the storage means is charged a predetermined amount; if the storage means is charged a predetermined amount, then detecting at least another R-R interval; and only if another R-R interval is shorter than a selected amount before sinus rhythm is redetected, then delivering a shock to the heart.
In accordance with the device of the present invention, the shock is delivered to the heart substantially immediately following the sensing of an R-wave after a short ~i.e., arrhythmia) interval.
A more detailed explanation of the invention is provided in the following description and claims, and as illustrated in the following drawings.

~38~

.

BRIEF DESCRIPTION O~ THE DRAWINGS

Fig. 1 is a block diagram of an implantable defibrillator constructed in accordance with the principles of the present invention.
Fig. 2 is a timing diagram of an operation thereof.
Fig. 3 is a timing diagram of another operation thereof.
Fig. 4 is a timing diagram of a still further operation thereof.
Fig. 5 is a flow chart of a method in accordance with the principles of the present invention.

DETAILED DESCRIPTION OF THE
ILLUSTRATIVE ENBODIMEN~

Referring to Figure 1, the block diagram for the implantable defibrillator includes ~our ICs and a set of high voltage discretes. The battery produces a positive voltage with respect to ground that varies from about 6.4 volts when new, to 5.0 volts at the end of service. The battery directly powers IC2 30 and the hiyh voltage discretes 60.
IC2 contains a band-gap reference circuit 31 that produces 1.235 volts, and 3 volt regulator that ~:L3~

powers the microprocessor 90, IC1 70, and the ECG storage RAM 77 through line 100. The 3 volt regulator runs off of a switched capacitor V 2/3 battery voltage down converter 33 for improved e~ficiency.
The microprocessor 90 communicates with IC2 through a data and address bus 83 and an on-chip interface 34 that contains chip-select, address decoding and data bus logic as is typically used with microprocessor peripherals. The internal bus 35 allows the microprocessor to control a general purpose ADC 36, the atrial pace circuits 37, the ventricular pace circuits 38, and the ~V control and regulate block 39.
The ADC 36 is used by the microprocessor to measure the battery and other diagnostic voltages within the device.
The atrial pace circuits 37 include a DAC that provides the ability to pace at regulated voltages. It communicates with the atrium of a heart 40 through two lines. One line 41 is a switchable groundi the other line 42 is the pacing cathode and is also the input to the atrial sense amplifier, as will be described below.
The ventricular pace circuits 37 include a DAC
that provides the ability to pace at regulated voltages.
It communicates with the ventricle of a heart 40 through two lines. One line 43 is a switchable ground; the other 8 :1 4 line 44 is the pacing cathode and is also the input to the ventricular sense amplifier, as will be described below.
Both the atrial and ventricular pace lines pass through high voltage protection circuits 45 to keep the defibrillation voltages generated by the device from damaging the pacing circuits 37 and 38.
The HV control and regulate block 39 on IC2 30 is used by the microprocessor 90 to charge a high voltage capacitor included in the HV charge block 46 to a regulated voltage, and then to deliver the defibrillating pulse to the heart 40 through the action of switches in the HV delivery block 47. An HV sense line 48 is used by the HV regulation circuits 39 to monitor the defibrillating voltage duriny charging. An HV control bus 49 is used by the HV control circuits 39 to c~ntrol the switches in the HV delivery blocX 47 for delivering the defibrillating pulse to the electrodes 52, 53 through lines 50 and 51.
ICl 70 is another microprocessor peripheral and provides timing, interrupt, telemetry, ECG storage, and sensing functions.
A dual channel electrogram sensing and waveform analysis section 71 interfaces with the atrium and ~25 ventricle of the heart 40 through lines 42 and 44 respectively. The sensed electrogram is amplified and digitized. The ampllfiers contained in this section 71 have multiple gain settings that are under microprocessor control for maintaining an AGC. Features such as peak voltage and complex width are extracted by the waveform analysis circuits 71 for the microprocessor 90 to use in discriminating arrhythmias from normal sinus rhythm. The voltage reference 31 from IC2 30 is used by the digitizer circuit 71 in the usual ~ashion, and is supp]ied by line 7~.
The digitized ECG is provided to the RAM
controller 7~ through a bus 73. The RAM controller sequences through the addresses of a static RAM 77 to maintain a pretrigger area, and this produces a post trigger area upon command from the microprocessor 90.
The crystal and monitor block 78 has a lOOKHz crystal oscillator that provides clocks to the entire system. The monitor is a conventional R~C oscillator that provides a back-up clock if the crystal should fail.
The microprocessor communicates with ICl through two buses, 83 and 84. One bus ~3 is a conventional data and address bus and goes to an on-chip interface 81 that contains chip select, address decoding and data bus drivers as are typically used with microprocessor peripherals. The other bus ~ is a 2 ~

control bus. It allows the microprocessor to set up a variety of maskable interrupts for events like timer timeouts, and sense events. If an interrupt is not masked, and the corresponding event occurs, an interrupt is sent from ICl 70 to the microprocessor 90 to alPrt it of the occurrence. On IC1 70, the up control and interrupt section 79 contains microprocessor controllable timers and interrupt logic.
The device can communicate with the outside world through a telemetry interface 80. A coil ~05 is used in a conventional fashion to transmit and receive pulsed signals. The telemetry circuits g0 decode an incoming bit stream from an external coil 110 and hold the data for subssquent retrisval by~ths microprocessor 90. When used for transmitting, the~circuit 80 receives data from the microprocessor 90, encodes it, and provides ths timing to~ pulss the coil 105. The communication~
function is ussd to retrieve data from the implantsd device, and~ to change the modality of~ operation if ~0 required.
The microprocessor 90 is of conventionsl architecture comprising an ALU 91, a ROM 92, a~RAM 93, and interfacs clrcuits 9~. Ths ROM 92 contains the ~ program code that determines the operation of the device.
The RAM 93 is used to modify the operating ::

.
- ~ ,.,, , : : .
. .~

, , 201~

characteristics o~ the device as regards modality, pulse widths, pulse amplitudes, and so forth. Diagnostic data is also stored in the RAM for subsequent transmission to the outside world. The Algorithmic Logic Unit (ALU) 91 performs the logical operations directed by the program code in the ROM.
The program code is written to perform certain desirable functions which are best described in flowchart form.
Referring now to Fig. 2, waveform 2a represents the heart complex. It is illustrated starting off in sinus rhythm and then speeding up to a tachycardia at point d. Waveform 2b, the high voltage charging status indicator waveform, is a digital level that represents the high voltage charging. Waveform 2c is the master voltage which increases to point e, the point when thé
capacitors are fully charged and the high voltage charge automatically discontinues. However, it can be seen that at point e the arrhythmia ceased and there are no further short intervals. Thus no shock is delivered.
Referring to Fig. 3, heart complex waveform 3a commences with sinus rhythm and accelerates to a tachycardia at point d. The arrhythmia is sensed and the high voltage charging status line 3b goes high. However, the devlce continues to sense while charglng is :
.~ .

.

8 1 ~
, commencing and since the heart complex returned to sinus rhythm during charging, this is detected and the capacitor charying is terminated at point e even thouyh the target voltage is not reached. In this case, no shock is delivered because the rhythm returned to sinus during the charging of the capacitor.
Referring now to Fig. 4, heart complex trace 4a commences in sinus rhythm but speeds up to a tachycardia at point d. The arrhythmia is sensed, high 10 voltage charging line 4b goes high and stays high until the capacitors are fully charged as indicated on capacitor voltage line 4c, point e. High voltage charging line 4b goes low at point e and at this point the device is trying to s~nchronize and waits for the 15 next R-wave. After receiving the next R-wave, it awaits the next R-wave, and it determines that there is ~ long interval so the shock i5 not delivered. Thereafter, however, there is a short interval and the shock f is delivered to the heart.
A flowchart illustrating the method described with respect to time and timing diagrams is illustrated in Fig. 5. Fig. 5 illustrates the ventricular shock synchronizing procedure. First, the next R-wave is awaited 120. When the R-wave is sensed, the system 25 checks to see if an arrhythmia is still in progress 122.

~38~

If not, the capacitor charying is discontinued 124 and the routine is exited 126.
If the arrhythmia ls still in progress 122, the high voltage circuit is polled 128 to determine if the capacitors are fully charged 130. If the capacitors are not fully charged, return via 132 to the top of the loop and await the next R-wave 120. If the capacitors are fully charged, wait for one R-wave 134 and wait for another R-wave 136 and then a determination is made whether or not the interval between those two R-waves is short 138. If the interval was long, then verify whether or not the arrhythmia is still in progress 140. If the arrhythmia is not still in progress, then exit from the routine 142. If the arrhythmia is still in progress, then return to waiting for another R-wave 136. If a next R-R interval is now short, then a high~voltaqe sh:ock ls:
delivered to the heart 144 and th.e routine is exited 146.
It can be seen that~a novel method has been shown and described for cardiac defibrillation, ln which~ ;
a detected arrhythmia is checked during charging of the capacitors and the charglng is discontinued lf termination of the arrhythmia is detected. If charging is ~completed, however, a hlgh voltage shock is not delivered on the first sensed event after completion of charging. Further, even if charglng is completed, a high 2~13~1~

.

voltage shock is not delivered if the previous sense events were of long interval. This minlmizes the amount of high voltage charging that is necessary, with an associated decrease in battery usage. Further, it most effectively reduces the probability of delivering a shock into sinus rhythm.
Although an illustrative embodiment of the invention has been shown and described, it i5 to be understood that various modifications and substitutions may be made by those skilled in the art without departing from the novel spirit and scope of the present invention -

Claims (9)

1. A device for cardiac defibrillation which comprises:
an implantable defibrillator having means for sensing R-waves;
energy storage means;
charging means and discharging means;
means for sensing a patient's R-waves to detect R-R intervals;
means for commencing charging of said storage means if an arrhythmia is detected;
means for determining whether the arrhythmia is still in progress;
means for determining if said storage means is charged a predetermined amount if said arrhythmia is still in progress;

means for detecting another R-R interval if said storage means is charged said pre-determined amount; and means for delivering a shock to the heart if said another R-R interval is shorter than a selected amount.
2. A device as described in claim 1, including means for discontinuing the charging if said arrhythmia is not still in progress.
3. A device as described in claim 1, including means for delivering said shock to the heart substantially immediately following the sensing of an R-wave.
4. A device as described in claim 1, wherein including means for continuing to determine whether the arrhythmia is still in progress if said storage means is not charged said predetermined amount, and discontinuing the charging if the arrhythmia is not still in progress.
5. A device as described in Claim 4, including means for inhibiting the shock to the heart if said arrhythmia is not still in progress.
6. A device for cardiac defibrillation with an implantable defibrillator comprising:
energy storage means;
means for sensing a patient's R-waves to detect R-R intervals;

means for commencing charging of said storage means if an arrhythmia is detected;
means for determining whether the arrhythmia is still in progress;
means for discontinuing the charging if said arrhythmia is not still in progress;
means for determining if said storage means is charged a predetermined amount if said arrhythmia is still in progress;
means for detecting another R-R interval if said storage means is charged said predetermined amount;
means for delivering a shock to the heart if said another R-R interval is shorter than a amount;
means for determining whether the arrhythmia is still in progress if said another R-R interval is not shorter than a predetermined amount;
means for determining whether the previous R-R
interval was shorter than a selected amount if said arrhythmia is still in progress then detecting another R-wave;
means for delivering a shock to the heart if said previous R-R interval was shorter than a selected amount;
and means for inhibiting the delivery of a shock to the heart if said arrhythmia is not still in progress.
7. A device as described in claim 6, including:
means for continuing to determine whether the arrhythmia is still in progress if said storage means is not charged said predetermined amount; and means for discontinuing the charging if the arrhythmia is not still in progress, then discontinuing the charging.
8. A device for cardiac defibrillation which comprises:
an implantable defibrillator having means for sensing R-waves;
energy storage means;
charging means for charging the energy storage means;
discharging means for discharging the energy storage means and delivering a shock to the heart;
means for measuring R-R intervals from said sensed R-waves;
means for commencing charging of said storage means if an arrhythmia is detected;

means for determining whether the arrhythmia is still in progress;
means for discontinuing the charging if the arrhythmia is not still in progress;
means for detecting another R-R interval if said storage means is charged a predetermined amount; and said discharging means being operable to deliver said shock to the heart if said another R-R interval is shorter than a selected amount.
9. A device as described in Claim 8, including means for determining if said storage means is charged a predetermined amount if said arrhythmia is still in progress.
CA002013814A 1989-04-26 1990-04-04 Device for cardiac defibrillation Abandoned CA2013814A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/344,011 US4949719A (en) 1989-04-26 1989-04-26 Method for cardiac defibrillation
US344,011 1989-04-26

Publications (1)

Publication Number Publication Date
CA2013814A1 true CA2013814A1 (en) 1990-10-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (5)

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US (1) US4949719A (en)
EP (1) EP0395242B1 (en)
AT (1) ATE119793T1 (en)
CA (1) CA2013814A1 (en)
DE (1) DE69017743T2 (en)

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ATE119793T1 (en) 1995-04-15
EP0395242A2 (en) 1990-10-31

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