CA2020614A1 - Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid - Google Patents
Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluidInfo
- Publication number
- CA2020614A1 CA2020614A1 CA002020614A CA2020614A CA2020614A1 CA 2020614 A1 CA2020614 A1 CA 2020614A1 CA 002020614 A CA002020614 A CA 002020614A CA 2020614 A CA2020614 A CA 2020614A CA 2020614 A1 CA2020614 A1 CA 2020614A1
- Authority
- CA
- Canada
- Prior art keywords
- catheter
- infusion section
- fluid
- passageways
- sheath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M2025/0175—Introducing, guiding, advancing, emplacing or holding catheters having telescopic features, interengaging nestable members movable in relations to one another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M25/0075—Valve means
Abstract
INTRAVASCULAR CATHETER HAVING AN ADJUSTABLE
LENGTH INFUSION SECTION TO DELIVER THERAPEUTIC FLUID
ABSTRACT OF THE DISCLOSURE
An elongated catheter assembly for the intravascular delivery of therapeutic fluids which has an infusion section on the distal end for the discharge of fluids to the exterior of the catheter and an elongated sheath which moves longitudinally to vary the length of the infusion section through which treatment fluid can pass. The sheath preferably is elongated so that the position thereof can be ajusted from the proximal end of the catheter assembly. In this manner, the effective length of the infusion section can be adjusted to the length of the treatment site, such as a thrombus.
LENGTH INFUSION SECTION TO DELIVER THERAPEUTIC FLUID
ABSTRACT OF THE DISCLOSURE
An elongated catheter assembly for the intravascular delivery of therapeutic fluids which has an infusion section on the distal end for the discharge of fluids to the exterior of the catheter and an elongated sheath which moves longitudinally to vary the length of the infusion section through which treatment fluid can pass. The sheath preferably is elongated so that the position thereof can be ajusted from the proximal end of the catheter assembly. In this manner, the effective length of the infusion section can be adjusted to the length of the treatment site, such as a thrombus.
Description
INTRAVASCUI~R CATHETER HAVING AN ADJUSTABLE
LENGTH INFUSION SECTION TQ DELIVER THERAPEUTIC FLUID
BACKGROUND OF THE INVENTION
This invention generally relates to a vascular catheter which ~elivers therapeutic ~luid to a desired location within a patient's vasculature.
Therapeu-tic fluids such as those containing urokinase, streptokinase, tissue plasminogen activator (TPA) have been found effective in many instances in the treatment of vascular thrombosis. The systemic administration of such therapeutic agents is not always desirable because the entire body of the patient must be medicated in order to treat small vascular sites. Delivery of therapeutic fluids through vascular catheters directly to a desired treatment site is usually more effective and, moreover, with direct deliv~ry higher concentrations o~ the therapeutic agent may be used in the treating solution.
In the direct delivery of therapeutic fluid to a thrombotic region in the patient's vasculature, it is highly desirable to limit the application of the therapeutic fluid ; ; only to the treatment site to limit the amount of therapeutic agent used (which can be Yery expensive3 and to avoid over medicating the patient. Frequently, there are multiple treatment sites of various lengths which re~uire the use of multiple ca~heters having at the distal end thereof drug delivery sections of various lengths to effectively deliver the treatment fluid only to the treatment site. In these instances, either a separate catheter must be used at each treatment site, which increases the time and the inconvenience of the procedure, or inefficient application of the treatment 2~ $1~
fluid must be accepted.
What has been needed is a catheter delivery system which can deliver therapeutic fluids to one or more thrombotic sites with means to adjust the effective l~ngth of drug delivery section of the catheter body, particularly after the catheter has been inserted into the pa~ient's blood vessels. The present invention provides a catheter which satisfies this need.
SUMMARY OF THE INVENTION
The present invention provides a catheter for the ,intravascular delivery of therapeutic fluid, comprising: an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter; an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
In one presently preferred embodiment, a snugly fitting sheath is slidably mounted onto the exterior of the catheter body so that longitudinal or axial movement of the sheath with respect to the catheter body blocks or~unblocks a greater or lesser number of fluid ~low passayeways in the wall of the infusion section. In another presently preferred embodiment, a tubular sheath snugly fits within the interior of the catheter body and is adapted to be slidable therein so that a greater or lesser number of fluid flow passageways passing through the wall of the infusion section are blocked or unblocked to thereby control the effective length of the infusion section.
The elongated catheter body generally has an outer tubular element and an inner tubular element coaxially disposed within the outer tubular element with the distal ends of ~hese tubular members sealingly bonded together to prevent loss o~ therapeutic fluids therefrom. An annular lumen which is defined between the inner and outer tubular element directs therapeutic fluids from an adapter provided on the proximal end of the catheter body to the distal portion thereof having the infusion section. The length of the infusion section in the distal portion of the catheter which is effective in infusing therapeutic fluid may be adjusted prior to or a~ter inserting the catheter into a patient's vascular system.
These adjustments are performed from the proximal end of the catheter which normally extends out of the patient during the vasc~llar procedure.
These and other advantages of the invention will become more apparent from the following detailed descxiption of the invention when taken in conjunction with the accompanying exemplary drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. l is an elevational view partially in section of a drug delivery catheter em~odying features of the invention;
FIG. 2 is an enlaged view of the distal erld of the catheter shown in FIG. 1 partially in section;
FIG. 3 is a transverse cross-sectional view of the catheter shown in FIGo 1 taken along the lines 2-2;
FIG. 4 is an elevational view of another drug delivery catheter embodying features of the invention;
~ 2 ~
FIG. 5 is an enlarged sectional view of the distal end of the catheter shown in FIG. 4 taken along the lines 5-5 shown in FIG. 4;
FIG. 6 is a cross-sectional view of the drug delivery catheter shown in FIG. 3 taken along the lines 6-6; and FIG. 7 is a partial longitudinal view in section of a distal section of a drug delivery system similar to that shown in FIG. 1 with a porous section to discharge fluid through the wall of the catheter.
DETAILED_DESCRIPTION OF THE INVENTION
Reference is made to FIGS. 1-3 which illustrate a catheter assembly for the intravascular delivery of therapeutic fluids. The catheter assembly 10 generally includes an elongated catheter body 11 having an outer tubular element 12 and an inner tubular element 13 concentrically disposed therein, an adapter 14 on the proximal end of the catheter body, and an elongated sheath 1~ mounted for slidable movement on the exterior of the catheter body 11.
The inner and outer tubular elements 13 and 12, respectively, define therebetween an annular lumen 16 for directing treatment fluid to the infusion section 17 in the distal portion of the catheter body 11 wherein fluid flow passageways 18 provided in the wall 19 of the outer tubular element 12. The distal ends of the inner and outer tubular elements ~3 and 12 are sealingly bonded such as by adhesive, heat shrinking, or other suitable means to prevent loss of the treatment fluid therefrom. The inner tubular element 13 is provided with an inner lumen 20 adapted to receive a guidewire (not shown) which facilitates advancing the catheter to the desired vascular site.
2~2 ~
The adapter 14 has a side arm 21 which directs therapeutic fluid to the annular lumen 16 in the catheter body 11. A guidewire would extend through the proximal end 22 of the adapter into the inner lumen 20.
The outer elongated tubular sheath 15 is mounted about the outer tubular element 12 for slidable longitudinal movement thereon. The distal end of the sheath 15 fits the outer tubular element 12 snugly so as to effectively prevent discharge fluid through the blocked passageways. A
tightenable collar 23 is provided on the sheath 15 to fix the relative longitudinal position of the sheath with respect to the outer tubular element. It also seals the proximal end of the sheath to prevent leakage of treatment fluid therefrom.
Radiopaque marker 24 is provided on the distal end of the sheath 15 and radiopa~ue markers 25 and 26 are provided on the proximal and distal ends of the infusion section 17 to be able to fluoroscopically visualize these components when the catheter is inserted into the patient's vasculature.
The passageways or ports 18 are provided through the wall of the distal portion of the outer tubular element 12 between the two markers 25 and 26 to infuse therapeutic fluids at a desired vascular site. The length of the infusion section 17 which is effective in discharging fluid is varied by changing the relative longitudinal position of the distal end of the sheath 15 thereon to accommodate thrombi of various lengths.
In utilizing the invention, the catheter assembly 10 is introduced into the patient's vascular system percutaneously through a guiding catheter with a guidewire slidably disposed within the inner lumen 20 of the inner tubular element 12.
Once the infusion section 17 is properly positione~ within a desired location, the length thereof which is exposed is adjusted by axial movement of the sheath 15 at the proximal end thereof which extends out of the patient. The effective 2~2~
length of the infusion section 17 is preferably the approximate length of the thrombus site to be treated. Other treatment sites of different len~ths can also be subsequently treated by readjusting the effective length of the infusion section in essentially the same manner.
FIGS. 4, 5 and 6 illustrate an alternative catheter assembly 40 which is similar in many respects to the catheter assembly shown in FIGS. 1 and 3. In this embodiment, the catheter body 41 has inner and outer tubular elements 42 and 43. The tubular sheath 45 is slidabl~ mounted within the interior of the outer tubular element 42 and an adapter 44 is provided on the proximal end thereof. The proximal end of the outer tubular element 42 is provided with a tightenable collar 46 which sealingly engages the exterior of the sheath 45 and thereby fixes the relative position between the sheath 45 and the outer tubular element 42.
The proximal ends of the sheath 45 and the inner tubular element 43 are secured to the adapter 44. The side arm 47 of adapter 44 directs treatment fluid through the annular passageway 50 disposed between the inner tubular element 43 and the sheath 45 and/or the outer tubular member 42 to the infusion section 51. The infusion section 51 is provided with fluid flow passageways 52 for infusing treatment fluid through wall 53 in the outer tubular element 42 to the exterior of the catheter body 41. A guidewire (not shown) extends through the proximal end 54 of the adapter 44 into the inner lumen 55 provided in inner tubular element 43.
The embodiment shown in FIGS. 4-6 operates in a similar manner as the catheter assembly shown 'in FIGS. 1 -3 except that the proximal end of the outer tubular element 42 is secured to the exterior of the sheath 45 by means of the collar 46 to fix the relative position therebetween. As the outer tubular element 42 is moved longitudinally over the sheath 45, a greater or lesser number of infusion ports 52 are opened thereby adjusting the effective length of the infusion section 51.
As shown in FIG. 7, the fluid flow passageways 52 and 18 of the prior embodiment may be replaced by porous sections 60 formed of suitable plastic material which allows the passage of the treatment ~luid from the annular lumen 51 to the exterior of the catheter. Indeed, the entire infusion section can be formed from a porous plastic material.
The sheath and the inner and outer tubular elements of the catheter body may be formed from suitable plastic materials, such as polyethylene, polyimide and polyesters such as Hytrel 7246, which is a block copolymer of polybutylene terephthalate and long chain polyester glycols. Hytrel is a trademark of the DuPont company. Porous plastic materials for fluid discharge may be formed from polypropylene.
In the embodiment shown in FIGS. 1-3, the sheath 15 is typically about 90 cm in length with an inner diameter of about 0.059 inch (1.5 mm) and an outer diameter of about 0.065 inch (1.65 mm). The outer tubular element 12 of this embodiment has a length of about 130 cm with an inner diameter of about 0.051 inch (1.3 mm) and an outer diameter of about 0.059 inch (1.5 mm)and the inner tubular element 13 has a length of about 130 cm, an inner diameter of about 0.040 inch (1 mm), and an outer diameter of about 0.047 inch (1.2 mm).
In the embodiment shown in FIGS. 4 6, typically the sheath 45 is about 90 cm in length with an inner diameter oE about 0.051 inch (1.3 mm) and an outer diameter of about 0.055 inch (1.4 mm). The outer tubular element 42 has a length of about 90 cm with an inner diameter of about 0.055 inch (1.4 mm)and an outer diameter of about 0.063 inch (1.6 mm), and the inner tubular element 43 has a length of about 120 cm, an inner diameter of about 0.040 inch (l mm), and an outer diameter of about 0.047 inch (1.2 mm). The dimensions of the components may vary widely, depending upon the vascular use of the catheter.
The infusion seckions 17 and 51 are about 10-30 cm in length, typically about 20, cm with about 30 passageways provided in the wall of the outer members 12 and 42 with effective diameters of about 0.005 inch (0.127 mm).
Preferably the passageways are aligned along the length of the outer tubular element in 3 spirals of 10 passageways each.
If porous plastic materials are employed for fluid discharge, it should have an effective pore size of about 2 to about 20 microns.
The number and effective size of the passageways or porous sections will be determined to a large extent upon the desired flow rate of therapeutic fluids and the pressure thereof in the annular lumen between the inner and outer tubular members which form the catheter body. The typical values given above wexe designed for a flow rate of about 80 cc's per hour at a pressure of about 3 to 10 psi (20,000 to 69,000 Pa). Other ~low rates and pressures may require a different number of passageways and different passageway diameters.
Various modifications and improvements can be made to the present invention. For example, in the preferred embodiments described herein, a single annular lumen is employed to direct treatment fluid to the entire infusion section. However, in order to provide a more uniform delivery of the treatment fluid, the annular lumen may be compartmentalized as described and claimed in copending application Serial No. ~,~D~, o~Y-i filed January 3, 1990 which is hereby incorporated by reference in its entirety. In this modification, each compartment of the annular lumen will supply fluid to a particular set of passageways. Preferably, such lumen compartment has a separate source of treatment fluid~
Other modifications and improvements can be made without departing from the scope of the invention.
LENGTH INFUSION SECTION TQ DELIVER THERAPEUTIC FLUID
BACKGROUND OF THE INVENTION
This invention generally relates to a vascular catheter which ~elivers therapeutic ~luid to a desired location within a patient's vasculature.
Therapeu-tic fluids such as those containing urokinase, streptokinase, tissue plasminogen activator (TPA) have been found effective in many instances in the treatment of vascular thrombosis. The systemic administration of such therapeutic agents is not always desirable because the entire body of the patient must be medicated in order to treat small vascular sites. Delivery of therapeutic fluids through vascular catheters directly to a desired treatment site is usually more effective and, moreover, with direct deliv~ry higher concentrations o~ the therapeutic agent may be used in the treating solution.
In the direct delivery of therapeutic fluid to a thrombotic region in the patient's vasculature, it is highly desirable to limit the application of the therapeutic fluid ; ; only to the treatment site to limit the amount of therapeutic agent used (which can be Yery expensive3 and to avoid over medicating the patient. Frequently, there are multiple treatment sites of various lengths which re~uire the use of multiple ca~heters having at the distal end thereof drug delivery sections of various lengths to effectively deliver the treatment fluid only to the treatment site. In these instances, either a separate catheter must be used at each treatment site, which increases the time and the inconvenience of the procedure, or inefficient application of the treatment 2~ $1~
fluid must be accepted.
What has been needed is a catheter delivery system which can deliver therapeutic fluids to one or more thrombotic sites with means to adjust the effective l~ngth of drug delivery section of the catheter body, particularly after the catheter has been inserted into the pa~ient's blood vessels. The present invention provides a catheter which satisfies this need.
SUMMARY OF THE INVENTION
The present invention provides a catheter for the ,intravascular delivery of therapeutic fluid, comprising: an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter; an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
In one presently preferred embodiment, a snugly fitting sheath is slidably mounted onto the exterior of the catheter body so that longitudinal or axial movement of the sheath with respect to the catheter body blocks or~unblocks a greater or lesser number of fluid ~low passayeways in the wall of the infusion section. In another presently preferred embodiment, a tubular sheath snugly fits within the interior of the catheter body and is adapted to be slidable therein so that a greater or lesser number of fluid flow passageways passing through the wall of the infusion section are blocked or unblocked to thereby control the effective length of the infusion section.
The elongated catheter body generally has an outer tubular element and an inner tubular element coaxially disposed within the outer tubular element with the distal ends of ~hese tubular members sealingly bonded together to prevent loss o~ therapeutic fluids therefrom. An annular lumen which is defined between the inner and outer tubular element directs therapeutic fluids from an adapter provided on the proximal end of the catheter body to the distal portion thereof having the infusion section. The length of the infusion section in the distal portion of the catheter which is effective in infusing therapeutic fluid may be adjusted prior to or a~ter inserting the catheter into a patient's vascular system.
These adjustments are performed from the proximal end of the catheter which normally extends out of the patient during the vasc~llar procedure.
These and other advantages of the invention will become more apparent from the following detailed descxiption of the invention when taken in conjunction with the accompanying exemplary drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. l is an elevational view partially in section of a drug delivery catheter em~odying features of the invention;
FIG. 2 is an enlaged view of the distal erld of the catheter shown in FIG. 1 partially in section;
FIG. 3 is a transverse cross-sectional view of the catheter shown in FIGo 1 taken along the lines 2-2;
FIG. 4 is an elevational view of another drug delivery catheter embodying features of the invention;
~ 2 ~
FIG. 5 is an enlarged sectional view of the distal end of the catheter shown in FIG. 4 taken along the lines 5-5 shown in FIG. 4;
FIG. 6 is a cross-sectional view of the drug delivery catheter shown in FIG. 3 taken along the lines 6-6; and FIG. 7 is a partial longitudinal view in section of a distal section of a drug delivery system similar to that shown in FIG. 1 with a porous section to discharge fluid through the wall of the catheter.
DETAILED_DESCRIPTION OF THE INVENTION
Reference is made to FIGS. 1-3 which illustrate a catheter assembly for the intravascular delivery of therapeutic fluids. The catheter assembly 10 generally includes an elongated catheter body 11 having an outer tubular element 12 and an inner tubular element 13 concentrically disposed therein, an adapter 14 on the proximal end of the catheter body, and an elongated sheath 1~ mounted for slidable movement on the exterior of the catheter body 11.
The inner and outer tubular elements 13 and 12, respectively, define therebetween an annular lumen 16 for directing treatment fluid to the infusion section 17 in the distal portion of the catheter body 11 wherein fluid flow passageways 18 provided in the wall 19 of the outer tubular element 12. The distal ends of the inner and outer tubular elements ~3 and 12 are sealingly bonded such as by adhesive, heat shrinking, or other suitable means to prevent loss of the treatment fluid therefrom. The inner tubular element 13 is provided with an inner lumen 20 adapted to receive a guidewire (not shown) which facilitates advancing the catheter to the desired vascular site.
2~2 ~
The adapter 14 has a side arm 21 which directs therapeutic fluid to the annular lumen 16 in the catheter body 11. A guidewire would extend through the proximal end 22 of the adapter into the inner lumen 20.
The outer elongated tubular sheath 15 is mounted about the outer tubular element 12 for slidable longitudinal movement thereon. The distal end of the sheath 15 fits the outer tubular element 12 snugly so as to effectively prevent discharge fluid through the blocked passageways. A
tightenable collar 23 is provided on the sheath 15 to fix the relative longitudinal position of the sheath with respect to the outer tubular element. It also seals the proximal end of the sheath to prevent leakage of treatment fluid therefrom.
Radiopaque marker 24 is provided on the distal end of the sheath 15 and radiopa~ue markers 25 and 26 are provided on the proximal and distal ends of the infusion section 17 to be able to fluoroscopically visualize these components when the catheter is inserted into the patient's vasculature.
The passageways or ports 18 are provided through the wall of the distal portion of the outer tubular element 12 between the two markers 25 and 26 to infuse therapeutic fluids at a desired vascular site. The length of the infusion section 17 which is effective in discharging fluid is varied by changing the relative longitudinal position of the distal end of the sheath 15 thereon to accommodate thrombi of various lengths.
In utilizing the invention, the catheter assembly 10 is introduced into the patient's vascular system percutaneously through a guiding catheter with a guidewire slidably disposed within the inner lumen 20 of the inner tubular element 12.
Once the infusion section 17 is properly positione~ within a desired location, the length thereof which is exposed is adjusted by axial movement of the sheath 15 at the proximal end thereof which extends out of the patient. The effective 2~2~
length of the infusion section 17 is preferably the approximate length of the thrombus site to be treated. Other treatment sites of different len~ths can also be subsequently treated by readjusting the effective length of the infusion section in essentially the same manner.
FIGS. 4, 5 and 6 illustrate an alternative catheter assembly 40 which is similar in many respects to the catheter assembly shown in FIGS. 1 and 3. In this embodiment, the catheter body 41 has inner and outer tubular elements 42 and 43. The tubular sheath 45 is slidabl~ mounted within the interior of the outer tubular element 42 and an adapter 44 is provided on the proximal end thereof. The proximal end of the outer tubular element 42 is provided with a tightenable collar 46 which sealingly engages the exterior of the sheath 45 and thereby fixes the relative position between the sheath 45 and the outer tubular element 42.
The proximal ends of the sheath 45 and the inner tubular element 43 are secured to the adapter 44. The side arm 47 of adapter 44 directs treatment fluid through the annular passageway 50 disposed between the inner tubular element 43 and the sheath 45 and/or the outer tubular member 42 to the infusion section 51. The infusion section 51 is provided with fluid flow passageways 52 for infusing treatment fluid through wall 53 in the outer tubular element 42 to the exterior of the catheter body 41. A guidewire (not shown) extends through the proximal end 54 of the adapter 44 into the inner lumen 55 provided in inner tubular element 43.
The embodiment shown in FIGS. 4-6 operates in a similar manner as the catheter assembly shown 'in FIGS. 1 -3 except that the proximal end of the outer tubular element 42 is secured to the exterior of the sheath 45 by means of the collar 46 to fix the relative position therebetween. As the outer tubular element 42 is moved longitudinally over the sheath 45, a greater or lesser number of infusion ports 52 are opened thereby adjusting the effective length of the infusion section 51.
As shown in FIG. 7, the fluid flow passageways 52 and 18 of the prior embodiment may be replaced by porous sections 60 formed of suitable plastic material which allows the passage of the treatment ~luid from the annular lumen 51 to the exterior of the catheter. Indeed, the entire infusion section can be formed from a porous plastic material.
The sheath and the inner and outer tubular elements of the catheter body may be formed from suitable plastic materials, such as polyethylene, polyimide and polyesters such as Hytrel 7246, which is a block copolymer of polybutylene terephthalate and long chain polyester glycols. Hytrel is a trademark of the DuPont company. Porous plastic materials for fluid discharge may be formed from polypropylene.
In the embodiment shown in FIGS. 1-3, the sheath 15 is typically about 90 cm in length with an inner diameter of about 0.059 inch (1.5 mm) and an outer diameter of about 0.065 inch (1.65 mm). The outer tubular element 12 of this embodiment has a length of about 130 cm with an inner diameter of about 0.051 inch (1.3 mm) and an outer diameter of about 0.059 inch (1.5 mm)and the inner tubular element 13 has a length of about 130 cm, an inner diameter of about 0.040 inch (1 mm), and an outer diameter of about 0.047 inch (1.2 mm).
In the embodiment shown in FIGS. 4 6, typically the sheath 45 is about 90 cm in length with an inner diameter oE about 0.051 inch (1.3 mm) and an outer diameter of about 0.055 inch (1.4 mm). The outer tubular element 42 has a length of about 90 cm with an inner diameter of about 0.055 inch (1.4 mm)and an outer diameter of about 0.063 inch (1.6 mm), and the inner tubular element 43 has a length of about 120 cm, an inner diameter of about 0.040 inch (l mm), and an outer diameter of about 0.047 inch (1.2 mm). The dimensions of the components may vary widely, depending upon the vascular use of the catheter.
The infusion seckions 17 and 51 are about 10-30 cm in length, typically about 20, cm with about 30 passageways provided in the wall of the outer members 12 and 42 with effective diameters of about 0.005 inch (0.127 mm).
Preferably the passageways are aligned along the length of the outer tubular element in 3 spirals of 10 passageways each.
If porous plastic materials are employed for fluid discharge, it should have an effective pore size of about 2 to about 20 microns.
The number and effective size of the passageways or porous sections will be determined to a large extent upon the desired flow rate of therapeutic fluids and the pressure thereof in the annular lumen between the inner and outer tubular members which form the catheter body. The typical values given above wexe designed for a flow rate of about 80 cc's per hour at a pressure of about 3 to 10 psi (20,000 to 69,000 Pa). Other ~low rates and pressures may require a different number of passageways and different passageway diameters.
Various modifications and improvements can be made to the present invention. For example, in the preferred embodiments described herein, a single annular lumen is employed to direct treatment fluid to the entire infusion section. However, in order to provide a more uniform delivery of the treatment fluid, the annular lumen may be compartmentalized as described and claimed in copending application Serial No. ~,~D~, o~Y-i filed January 3, 1990 which is hereby incorporated by reference in its entirety. In this modification, each compartment of the annular lumen will supply fluid to a particular set of passageways. Preferably, such lumen compartment has a separate source of treatment fluid~
Other modifications and improvements can be made without departing from the scope of the invention.
Claims (13)
1. A catheter for the intravascular delivery of therapeutic fluid, comprising:
a) an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter;
b) an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and c) means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
a) an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter;
b) an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and c) means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
2. The catheter of claim 1 wherein the means to pass fluid through the wall of the infusion section is a plurality of passageways.
3. The catheter of claim 2 wherein the passageways have an effective diameter of about 0.002 to about 0.01 inch.
4. The catheter of claim 3 wherein there are about 20 to about 40 passageways in the infusion section.
5. The catheter of claim 4 wherein the passageways through the wall of the infusion section are disposed spirally along the length of the infusion section.
6. The catheter of claim 5 wherein the passageways extend about one complete revolution about the catheter body.
7. The catheter of claim 6 wherein there are a plurality of spiral lines of passageways.
8. The catheter of claim 1 wherein the means to adjust the effective length of the infusion section is a sheath, the longitudinal movement of which closes or opens fluid flow passageways in the wall of the infusion section.
9. The catheter of claim 1 wherein the means to pass fluid through the wall of the infusion section comprises porous plastic material.
10. The catheter of claim 8 wherein the sheath is disposed on the exterior of the catheter body and has a proximal end with a means to sealingly secure said proximal end to the catheter body.
11. The catheter of claim 10 wherein the catheter body comprises an outer tubular element an inner tubular element concentrically disposed therein which defines therebetween an annular lumen for directing therapeutic fluid to the infusion section.
12 12. The catheter of claim 8 wherein the catheter body comprises an outer tubular element and an inner tubular member concentrically disposed therein and wherein the sheath is disposed on the inner surface of the outer tubular element.
13. The catheter of claim 12 wherein the outer tubular member has on the proximal end thereof means to sealingly engage the exterior of the sheath.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US377,243 | 1989-07-07 | ||
US07/377,243 US4968306A (en) | 1989-07-07 | 1989-07-07 | Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid |
Publications (1)
Publication Number | Publication Date |
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CA2020614A1 true CA2020614A1 (en) | 1991-01-08 |
Family
ID=23488330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002020614A Abandoned CA2020614A1 (en) | 1989-07-07 | 1990-07-06 | Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid |
Country Status (4)
Country | Link |
---|---|
US (1) | US4968306A (en) |
EP (1) | EP0406901A1 (en) |
JP (1) | JPH03131272A (en) |
CA (1) | CA2020614A1 (en) |
Families Citing this family (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083220A (en) | 1990-03-13 | 2000-07-04 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
USRE42625E1 (en) | 1990-03-13 | 2011-08-16 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
USRE42756E1 (en) | 1990-03-13 | 2011-09-27 | The Regents Of The University Of California | Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US5250034A (en) * | 1990-09-17 | 1993-10-05 | E-Z-Em, Inc. | Pressure responsive valve catheter |
US5178611A (en) * | 1991-05-01 | 1993-01-12 | Paul Rosenberg | Device and method for inhibiting intravascular device associated infection |
WO1994015661A1 (en) * | 1991-05-01 | 1994-07-21 | Rosenberg Paul H | Device and method for inhibiting intravascular device associated infection |
US5551448A (en) * | 1991-10-18 | 1996-09-03 | United States Surgical Corporation | Endoscopic surgical instrument for aspiration and irrigation |
AU656628B2 (en) * | 1991-10-18 | 1995-02-09 | United States Surgical Corporation | Endoscopic surgical instrument for aspiration and irrigation |
US5263952A (en) * | 1992-03-25 | 1993-11-23 | Spectranetics | Two-piece tip for fiber optic catheter |
US5368566A (en) * | 1992-04-29 | 1994-11-29 | Cardiovascular Dynamics, Inc. | Delivery and temporary stent catheter having a reinforced perfusion lumen |
US5569184A (en) * | 1992-04-29 | 1996-10-29 | Cardiovascular Dynamics, Inc. | Delivery and balloon dilatation catheter and method of using |
US5368579A (en) * | 1992-07-23 | 1994-11-29 | Sandridge; James B. | Perfusion controlled guiding catheter apparatus and method |
US5716410A (en) * | 1993-04-30 | 1998-02-10 | Scimed Life Systems, Inc. | Temporary stent and method of use |
ES2122073T3 (en) * | 1993-06-17 | 1998-12-16 | Angiomed Ag | DEVICE FOR THE DISSOLUTION OF THROMBS IN VESSELS THROUGH LYSIS. |
US5318535A (en) * | 1993-06-21 | 1994-06-07 | Baxter International Inc. | Low-profile dual-lumen perfusion balloon catheter with axially movable inner guide sheath |
JPH0751379A (en) * | 1993-06-24 | 1995-02-28 | Cardiovascular Dynamics Inc | Injection catheter, intravascular site treating method, and production of catheter |
US5409455A (en) * | 1993-07-09 | 1995-04-25 | Scimed Life Systems, Inc. | Vascular navigation and visualization assist device |
US5383890A (en) * | 1993-10-27 | 1995-01-24 | Baxter International Inc. | Low-profile single-lumen perfusion balloon catheter |
US5429617A (en) * | 1993-12-13 | 1995-07-04 | The Spectranetics Corporation | Radiopaque tip marker for alignment of a catheter within a body |
US5425723A (en) * | 1993-12-30 | 1995-06-20 | Boston Scientific Corporation | Infusion catheter with uniform distribution of fluids |
US5843093A (en) | 1994-02-09 | 1998-12-01 | University Of Iowa Research Foundation | Stereotactic electrode assembly |
US6129685A (en) * | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US7077822B1 (en) | 1994-02-09 | 2006-07-18 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
US5425714A (en) * | 1994-03-15 | 1995-06-20 | Cordis Corporation | Perfusion catheter with moving body |
US5415636A (en) * | 1994-04-13 | 1995-05-16 | Schneider (Usa) Inc | Dilation-drug delivery catheter |
US5514092A (en) * | 1994-08-08 | 1996-05-07 | Schneider (Usa) Inc. | Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration |
US5520662A (en) * | 1994-09-09 | 1996-05-28 | Moss; Gerald | Gastrointestinal aspirating and feeding device with removable sleeve |
AU5545596A (en) * | 1995-04-28 | 1996-11-18 | Medtronic, Inc. | Intraparenchymal infusion catheter system |
US7069634B1 (en) | 1995-04-28 | 2006-07-04 | Medtronic, Inc. | Method for manufacturing a catheter |
US5643228A (en) * | 1995-11-13 | 1997-07-01 | Uresil Corporation | Catheter |
US5662619A (en) * | 1995-11-27 | 1997-09-02 | Zarate; Alfredo R. | Venous dialysis needle |
US20030069522A1 (en) | 1995-12-07 | 2003-04-10 | Jacobsen Stephen J. | Slotted medical device |
US6090083A (en) | 1996-01-31 | 2000-07-18 | Scimed Life Systems, Inc. | Low profile valve and balloon catheter |
US6786888B1 (en) | 1996-05-20 | 2004-09-07 | Medtronic Ave, Inc. | Low profile catheter for emboli protection |
US6325777B1 (en) | 1996-05-20 | 2001-12-04 | Medtronic Percusurge, Inc. | Low profile catheter valve and inflation adaptor |
US6050972A (en) | 1996-05-20 | 2000-04-18 | Percusurge, Inc. | Guidewire inflation system |
US6958059B2 (en) | 1996-05-20 | 2005-10-25 | Medtronic Ave, Inc. | Methods and apparatuses for drug delivery to an intravascular occlusion |
ATE285812T1 (en) | 1996-05-20 | 2005-01-15 | Medtronic Percusurge Inc | LOW PROFILE CATHETER VALVE |
US6017319A (en) * | 1996-05-24 | 2000-01-25 | Precision Vascular Systems, Inc. | Hybrid tubular guide wire for catheters |
US5782797A (en) * | 1996-06-06 | 1998-07-21 | Scimed Life Systems, Inc. | Therapeutic infusion device |
US5893841A (en) * | 1996-08-30 | 1999-04-13 | Delcath Systems, Inc. | Balloon catheter with occluded segment bypass |
US5843043A (en) * | 1997-03-25 | 1998-12-01 | Markus; George | Syringe and process for dispensing treatment fluid |
US6063069A (en) * | 1997-05-19 | 2000-05-16 | Micro Therapeutics Inc. | Method and apparatus for power lysis of a thrombus |
US6635027B1 (en) | 1997-05-19 | 2003-10-21 | Micro Therepeutics, Inc. | Method and apparatus for intramural delivery of a substance |
US6179813B1 (en) | 1998-04-24 | 2001-01-30 | Scimed Life Systems, Inc. | Vascular infusion device |
US6508777B1 (en) | 1998-05-08 | 2003-01-21 | Cardeon Corporation | Circulatory support system and method of use for isolated segmental perfusion |
CN1102999C (en) * | 1998-05-22 | 2003-03-12 | 米罗斯拉夫·塞德拉切克 | Hydraulic motor |
US6726651B1 (en) | 1999-08-04 | 2004-04-27 | Cardeon Corporation | Method and apparatus for differentially perfusing a patient during cardiopulmonary bypass |
US6129700A (en) * | 1998-12-04 | 2000-10-10 | Advanced Cardiovascular Systems, Inc. | Contrast medium injection device and method of use |
US6395208B1 (en) | 1999-01-25 | 2002-05-28 | Atrium Medical Corporation | Method of making an expandable fluoropolymer device |
US7637886B2 (en) | 1999-01-25 | 2009-12-29 | Atrium Medical Corporation | Expandable fluoropolymer device and method of making |
US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US6210363B1 (en) | 1999-02-23 | 2001-04-03 | Cardeon Corporation | Methods and devices for occluding a vessel and performing differential perfusion |
US6210376B1 (en) | 1999-04-08 | 2001-04-03 | New York University | Cannulated delivery pin |
US6368315B1 (en) * | 1999-06-23 | 2002-04-09 | Durect Corporation | Composite drug delivery catheter |
US6852097B1 (en) * | 1999-06-24 | 2005-02-08 | Fulton, Iii Richard E. | Mechanically active infusion catheter |
US6241710B1 (en) * | 1999-12-20 | 2001-06-05 | Tricardia Llc | Hypodermic needle with weeping tip and method of use |
US6475185B1 (en) | 2000-02-24 | 2002-11-05 | Scimed Life Systems, Inc. | Occlusion device |
US6945969B1 (en) * | 2000-03-31 | 2005-09-20 | Medtronic, Inc. | Catheter for target specific drug delivery |
US6306106B1 (en) | 2000-06-19 | 2001-10-23 | Advanced Cardiovascular Systems, Inc. | Diagnostic sheath for reduced embolic risk |
US6685672B1 (en) * | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
US6464662B1 (en) * | 2000-07-26 | 2002-10-15 | Image-Guided Neurologics, Inc. | Drug delivery and catheter systems, apparatus and processes |
DE20020252U1 (en) * | 2000-11-29 | 2002-04-11 | Maslanka Herbert | Spray Catheters |
US6692458B2 (en) | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
DE60216593T2 (en) | 2001-07-05 | 2007-09-27 | Precision Vascular Systems, Inc., West Valley City | MEDICAL DEVICE WITH A TORQUE TRANSMITTED SOFT END PIECE AND METHOD FOR ITS FORMING |
DE20113545U1 (en) * | 2001-08-16 | 2001-12-20 | Rehau Ag & Co | catheter |
CA2458148C (en) * | 2001-08-22 | 2010-03-23 | Arteria Medical Science, Inc. | Apparatus and methods for treating stroke and controlling cerebral flow characteristics |
JP2003062082A (en) * | 2001-08-23 | 2003-03-04 | Buaayu:Kk | Ptcr catheter |
US6755813B2 (en) * | 2001-11-20 | 2004-06-29 | Cleveland Clinic Foundation | Apparatus and method for performing thrombolysis |
US6855136B2 (en) * | 2002-04-03 | 2005-02-15 | Gore Enterprise Holdings, Inc. | Infusion catheter having an atraumatic tip |
US9440046B2 (en) * | 2002-04-04 | 2016-09-13 | Angiodynamics, Inc. | Venous insufficiency treatment method |
US6730095B2 (en) * | 2002-06-26 | 2004-05-04 | Scimed Life Systems, Inc. | Retrograde plunger delivery system |
WO2008124790A2 (en) | 2002-07-10 | 2008-10-16 | Angiodynamics, Inc. | Device and method for endovascular treatment for causing closure of a blood vessel |
US7914467B2 (en) | 2002-07-25 | 2011-03-29 | Boston Scientific Scimed, Inc. | Tubular member having tapered transition for use in a medical device |
DE60334122D1 (en) | 2002-07-25 | 2010-10-21 | Boston Scient Ltd | MEDICAL DEVICE FOR NAVIGATING THROUGH ANATOMY |
US7613503B2 (en) | 2002-08-09 | 2009-11-03 | Boston Scientific Scimed, Inc. | Device with infusion holes for imaging inside a blood vessel |
US20040097880A1 (en) * | 2002-11-19 | 2004-05-20 | Angiodynamics, Inc. | Combination thrombolytic infusion catheter and dilator system |
US8043281B2 (en) | 2002-12-23 | 2011-10-25 | Medtronic, Inc. | Catheters incorporating valves and permeable membranes |
AU2003303387A1 (en) * | 2002-12-23 | 2004-07-22 | Medtronic, Inc. | Multiple infusion section catheters, systems, and methods |
US8246602B2 (en) | 2002-12-23 | 2012-08-21 | Medtronic, Inc. | Catheters with tracking elements and permeable membranes |
US8377035B2 (en) | 2003-01-17 | 2013-02-19 | Boston Scientific Scimed, Inc. | Unbalanced reinforcement members for medical device |
US20040143283A1 (en) * | 2003-01-17 | 2004-07-22 | Mcgill Scott | Inflation adaptor and method of use |
US7169118B2 (en) | 2003-02-26 | 2007-01-30 | Scimed Life Systems, Inc. | Elongate medical device with distal cap |
US7001369B2 (en) | 2003-03-27 | 2006-02-21 | Scimed Life Systems, Inc. | Medical device |
US20040260237A1 (en) * | 2003-06-17 | 2004-12-23 | Paul Squadrito | Inflation adaptor with magnetically-assisted loading |
US7226441B2 (en) * | 2003-06-23 | 2007-06-05 | Codman & Shurtleff, Inc. | Catheter with block-overriding system |
US7824345B2 (en) | 2003-12-22 | 2010-11-02 | Boston Scientific Scimed, Inc. | Medical device with push force limiter |
US9232948B2 (en) | 2003-12-23 | 2016-01-12 | Stryker Corporation | Catheter with distal occlusion apparatus |
WO2006023203A1 (en) * | 2004-08-19 | 2006-03-02 | Vein Rx, Inc. | An occludable intravascular catheter for drug delivery and method of using the same |
US20060085054A1 (en) * | 2004-09-09 | 2006-04-20 | Zikorus Arthur W | Methods and apparatus for treatment of hollow anatomical structures |
US20060229573A1 (en) * | 2005-04-08 | 2006-10-12 | Mckinley Medical L.L.L.P. | Adjustable infusion catheter |
US20070213671A1 (en) * | 2005-09-07 | 2007-09-13 | Hiatt Mark J | Infusion catheter system with telescoping cannula |
US7850623B2 (en) | 2005-10-27 | 2010-12-14 | Boston Scientific Scimed, Inc. | Elongate medical device with continuous reinforcement member |
US8961491B2 (en) * | 2006-04-21 | 2015-02-24 | Bayer Medical Care Inc | Catheters and related equipment |
US8551020B2 (en) | 2006-09-13 | 2013-10-08 | Boston Scientific Scimed, Inc. | Crossing guidewire |
US8556914B2 (en) | 2006-12-15 | 2013-10-15 | Boston Scientific Scimed, Inc. | Medical device including structure for crossing an occlusion in a vessel |
US8409114B2 (en) | 2007-08-02 | 2013-04-02 | Boston Scientific Scimed, Inc. | Composite elongate medical device including distal tubular member |
US8105246B2 (en) | 2007-08-03 | 2012-01-31 | Boston Scientific Scimed, Inc. | Elongate medical device having enhanced torque and methods thereof |
US8821477B2 (en) | 2007-08-06 | 2014-09-02 | Boston Scientific Scimed, Inc. | Alternative micromachined structures |
US9808595B2 (en) | 2007-08-07 | 2017-11-07 | Boston Scientific Scimed, Inc | Microfabricated catheter with improved bonding structure |
WO2009057774A1 (en) * | 2007-10-31 | 2009-05-07 | Olympus Corporation | Drug solution-administration system and cannula for administering drug solution |
US7841994B2 (en) | 2007-11-02 | 2010-11-30 | Boston Scientific Scimed, Inc. | Medical device for crossing an occlusion in a vessel |
US8157747B2 (en) | 2008-02-15 | 2012-04-17 | Lary Research & Development, Llc | Single-use indicator for a surgical instrument and a surgical instrument incorporating same |
US8376961B2 (en) | 2008-04-07 | 2013-02-19 | Boston Scientific Scimed, Inc. | Micromachined composite guidewire structure with anisotropic bending properties |
EP2341850B1 (en) * | 2008-07-09 | 2021-04-07 | CORAFLO Ltd liab. Co | Systems for caval stenting for venous drainage |
US8535243B2 (en) | 2008-09-10 | 2013-09-17 | Boston Scientific Scimed, Inc. | Medical devices and tapered tubular members for use in medical devices |
US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
US8795254B2 (en) | 2008-12-10 | 2014-08-05 | Boston Scientific Scimed, Inc. | Medical devices with a slotted tubular member having improved stress distribution |
US9433209B2 (en) | 2009-03-26 | 2016-09-06 | Organic Medical Ventures, L.L.C. | Transdermal venous access locking solutions |
US20100249747A1 (en) * | 2009-03-26 | 2010-09-30 | Organic Medical Ventures, L.L.C. | Transdermal venous access locking solution |
US9427498B2 (en) | 2009-03-26 | 2016-08-30 | Organic Medical Ventures, L.L.C. | Syringe treated with transdermal venous access locking solutions and method of treating the syringe |
US9072296B2 (en) | 2009-03-26 | 2015-07-07 | Organic Medical Ventures, L.L.C. | Transdermal venous access locking solutions |
US8137293B2 (en) | 2009-11-17 | 2012-03-20 | Boston Scientific Scimed, Inc. | Guidewires including a porous nickel-titanium alloy |
US9295816B2 (en) * | 2009-12-09 | 2016-03-29 | Osprey Medical, Inc. | Catheter with distal and proximal ports |
US10603466B2 (en) * | 2009-12-14 | 2020-03-31 | Michael G. Tal | Intravascular catheter with positioning markers and method of placement |
EP2531247B1 (en) | 2010-02-04 | 2017-01-04 | Guillermo L. Pol | Medical tubes for selective mechanical ventilation of the lungs |
JP2013521995A (en) * | 2010-03-24 | 2013-06-13 | シファメド・ホールディングス・エルエルシー | Endovascular tissue destruction |
US8551021B2 (en) | 2010-03-31 | 2013-10-08 | Boston Scientific Scimed, Inc. | Guidewire with an improved flexural rigidity profile |
PL2558154T3 (en) * | 2010-04-16 | 2020-11-30 | Clearpoint Neuro, Inc. | Mri surgical systems including mri-compatible surgical cannulae for transferring a substance to and/or from a patient |
KR20130086949A (en) | 2010-05-07 | 2013-08-05 | 케어퓨전 2200, 아이엔씨 | Catheter allowing variable dosing of an active agent |
AU2011252976A1 (en) | 2010-05-12 | 2012-11-08 | Shifamed Holdings, Llc | Low profile electrode assembly |
US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
US8905996B2 (en) * | 2010-11-01 | 2014-12-09 | Biomet Manufacturing, Llc | Cannulated syringe |
MX341823B (en) | 2011-02-01 | 2016-09-05 | Channel Medsystems Inc | Methods and apparatus for cyrogenic treatment of a body cavity or lumen. |
US8795202B2 (en) | 2011-02-04 | 2014-08-05 | Boston Scientific Scimed, Inc. | Guidewires and methods for making and using the same |
US9763735B2 (en) | 2011-02-24 | 2017-09-19 | Eximo Medical Ltd. | Hybrid catheter for endoluminal intervention |
US9072874B2 (en) | 2011-05-13 | 2015-07-07 | Boston Scientific Scimed, Inc. | Medical devices with a heat transfer region and a heat sink region and methods for manufacturing medical devices |
WO2012166168A1 (en) * | 2011-06-02 | 2012-12-06 | Atrium Medical Corporation | Body lumen fluid delivery device |
US8992513B2 (en) | 2011-06-30 | 2015-03-31 | Angiodynamics, Inc | Endovascular plasma treatment device and method of use |
US8702678B2 (en) | 2011-08-03 | 2014-04-22 | Venous Therapy, Inc. | Assemblies, systems, and methods for infusing therapeutic agents into the body |
EP2741804B1 (en) | 2011-08-11 | 2017-04-26 | Osprey Medical Inc. | Systems and methods for limb treatment |
HUE040153T2 (en) | 2011-08-31 | 2019-02-28 | Organic Medical Ventures L L C | Transdermal venous access locking solutions |
US9084647B2 (en) * | 2011-10-12 | 2015-07-21 | Globus Medical, Inc. | Screw with anchor features |
US8932270B2 (en) | 2012-04-11 | 2015-01-13 | Cook Medical Technologies Llc | Variable infusion length catheter and method |
US10279143B2 (en) * | 2013-03-11 | 2019-05-07 | Covidien Lp | Flushing stylet |
US9956383B2 (en) | 2013-03-15 | 2018-05-01 | Cook Medical Technologies Llc | Medical devices and methods for providing access to a bodily passage during dilation |
EP2983603B1 (en) | 2013-04-08 | 2020-03-25 | Apama Medical, Inc. | Cardiac ablation catheters |
US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
CN107837108B (en) * | 2013-05-23 | 2021-04-27 | 查内尔麦德系统公司 | Cryotherapeutic system |
US10220162B2 (en) * | 2014-01-07 | 2019-03-05 | Gil Vardi | Pericardial access device and its methods of use |
US9901706B2 (en) | 2014-04-11 | 2018-02-27 | Boston Scientific Scimed, Inc. | Catheters and catheter shafts |
CN104001254A (en) * | 2014-05-19 | 2014-08-27 | 天津博安医用有限公司 | Push sleeve applicable to intravenous thrombolysis catheter |
US9692557B2 (en) * | 2015-02-04 | 2017-06-27 | Stryker European Holdings I, Llc | Apparatus and methods for administering treatment within a bodily duct of a patient |
EP3253438B1 (en) * | 2015-02-04 | 2022-09-21 | Stryker European Operations Holdings LLC | Apparatus and methods for administering treatment within a bodily duct of a patient |
WO2016126369A1 (en) * | 2015-02-04 | 2016-08-11 | Stryker European Holdings I, Llc And Stryker Corporation, A Michigan Corporation | Apparatus and methods for administering treatment within a bodily duct of a patient |
EP4302713A2 (en) | 2015-11-16 | 2024-01-10 | Boston Scientific Scimed, Inc. | Energy delivery devices |
US11351048B2 (en) | 2015-11-16 | 2022-06-07 | Boston Scientific Scimed, Inc. | Stent delivery systems with a reinforced deployment sheath |
US11684420B2 (en) | 2016-05-05 | 2023-06-27 | Eximo Medical Ltd. | Apparatus and methods for resecting and/or ablating an undesired tissue |
US10857328B2 (en) * | 2018-01-16 | 2020-12-08 | Daniel Ezra Walzman | Bypass catheter |
US10857335B2 (en) | 2017-02-13 | 2020-12-08 | Daniel Ezra Walzman | Temporary bypass balloon catheter |
US10799674B2 (en) * | 2018-01-16 | 2020-10-13 | Daniel Ezra Walzman | Bypass catheter |
US11596769B2 (en) | 2018-01-16 | 2023-03-07 | Daniel Ezra Walzman | Bypass catheter |
US11596438B2 (en) | 2018-01-16 | 2023-03-07 | Daniel Ezra Walzman | Bypass catheter |
US11006996B2 (en) | 2018-01-16 | 2021-05-18 | Daniel Ezra Walzman | Torus balloon with energy emitters for intravascular lithotripsy |
US10926061B2 (en) | 2018-01-16 | 2021-02-23 | Daniel Ezra Walzman | Bypass catheter |
EP3810026A1 (en) * | 2018-06-25 | 2021-04-28 | Angelus Industria De Produtos Odontologicos S/A | Injection systems in the radicular canal system and use thereof |
EP3854437B1 (en) * | 2020-01-27 | 2022-01-19 | Heraeus Medical GmbH | Device for temporary local application of fluids |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE361793C (en) * | 1920-02-13 | 1922-10-19 | Wilhelm Rothenburger | catheter |
US3860006A (en) * | 1973-06-25 | 1975-01-14 | Kendall & Co | Suprapubic catheter system using an internal stylet |
LU77252A1 (en) * | 1976-05-06 | 1977-08-22 | ||
JPS5626738Y2 (en) * | 1977-03-31 | 1981-06-25 | ||
CA1092927A (en) * | 1979-12-28 | 1981-01-06 | Allentyne Limited | Hemodialysis cannula for subclavian insertion |
US4702260A (en) * | 1985-04-16 | 1987-10-27 | Ko Pen Wang | Flexible bronchoscopic needle assembly |
DE3523520A1 (en) * | 1985-07-01 | 1987-01-08 | Stoeckert Instr Gmbh | VESSEL CATHETER |
GB2181650B (en) * | 1985-10-18 | 1989-09-13 | Blagoveshchensk G Med Inst | Aortic cannula |
DE3731590C1 (en) * | 1987-09-19 | 1988-07-21 | Braun Melsungen Ag | Medical probe |
-
1989
- 1989-07-07 US US07/377,243 patent/US4968306A/en not_active Expired - Lifetime
-
1990
- 1990-07-06 EP EP90112965A patent/EP0406901A1/en not_active Withdrawn
- 1990-07-06 CA CA002020614A patent/CA2020614A1/en not_active Abandoned
- 1990-07-06 JP JP2179423A patent/JPH03131272A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US4968306A (en) | 1990-11-06 |
EP0406901A1 (en) | 1991-01-09 |
JPH03131272A (en) | 1991-06-04 |
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Legal Events
Date | Code | Title | Description |
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FZDE | Discontinued |