CA2020614A1 - Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid - Google Patents

Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid

Info

Publication number
CA2020614A1
CA2020614A1 CA002020614A CA2020614A CA2020614A1 CA 2020614 A1 CA2020614 A1 CA 2020614A1 CA 002020614 A CA002020614 A CA 002020614A CA 2020614 A CA2020614 A CA 2020614A CA 2020614 A1 CA2020614 A1 CA 2020614A1
Authority
CA
Canada
Prior art keywords
catheter
infusion section
fluid
passageways
sheath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002020614A
Other languages
French (fr)
Inventor
Beverly A. Huss
Robert W. Reinhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Cardiovascular Systems Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2020614A1 publication Critical patent/CA2020614A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M2025/0175Introducing, guiding, advancing, emplacing or holding catheters having telescopic features, interengaging nestable members movable in relations to one another
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0074Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
    • A61M25/0075Valve means

Abstract

INTRAVASCULAR CATHETER HAVING AN ADJUSTABLE
LENGTH INFUSION SECTION TO DELIVER THERAPEUTIC FLUID

ABSTRACT OF THE DISCLOSURE
An elongated catheter assembly for the intravascular delivery of therapeutic fluids which has an infusion section on the distal end for the discharge of fluids to the exterior of the catheter and an elongated sheath which moves longitudinally to vary the length of the infusion section through which treatment fluid can pass. The sheath preferably is elongated so that the position thereof can be ajusted from the proximal end of the catheter assembly. In this manner, the effective length of the infusion section can be adjusted to the length of the treatment site, such as a thrombus.

Description

INTRAVASCUI~R CATHETER HAVING AN ADJUSTABLE
LENGTH INFUSION SECTION TQ DELIVER THERAPEUTIC FLUID

BACKGROUND OF THE INVENTION

This invention generally relates to a vascular catheter which ~elivers therapeutic ~luid to a desired location within a patient's vasculature.
Therapeu-tic fluids such as those containing urokinase, streptokinase, tissue plasminogen activator (TPA) have been found effective in many instances in the treatment of vascular thrombosis. The systemic administration of such therapeutic agents is not always desirable because the entire body of the patient must be medicated in order to treat small vascular sites. Delivery of therapeutic fluids through vascular catheters directly to a desired treatment site is usually more effective and, moreover, with direct deliv~ry higher concentrations o~ the therapeutic agent may be used in the treating solution.
In the direct delivery of therapeutic fluid to a thrombotic region in the patient's vasculature, it is highly desirable to limit the application of the therapeutic fluid ; ; only to the treatment site to limit the amount of therapeutic agent used (which can be Yery expensive3 and to avoid over medicating the patient. Frequently, there are multiple treatment sites of various lengths which re~uire the use of multiple ca~heters having at the distal end thereof drug delivery sections of various lengths to effectively deliver the treatment fluid only to the treatment site. In these instances, either a separate catheter must be used at each treatment site, which increases the time and the inconvenience of the procedure, or inefficient application of the treatment 2~ $1~

fluid must be accepted.
What has been needed is a catheter delivery system which can deliver therapeutic fluids to one or more thrombotic sites with means to adjust the effective l~ngth of drug delivery section of the catheter body, particularly after the catheter has been inserted into the pa~ient's blood vessels. The present invention provides a catheter which satisfies this need.

SUMMARY OF THE INVENTION

The present invention provides a catheter for the ,intravascular delivery of therapeutic fluid, comprising: an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter; an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
In one presently preferred embodiment, a snugly fitting sheath is slidably mounted onto the exterior of the catheter body so that longitudinal or axial movement of the sheath with respect to the catheter body blocks or~unblocks a greater or lesser number of fluid ~low passayeways in the wall of the infusion section. In another presently preferred embodiment, a tubular sheath snugly fits within the interior of the catheter body and is adapted to be slidable therein so that a greater or lesser number of fluid flow passageways passing through the wall of the infusion section are blocked or unblocked to thereby control the effective length of the infusion section.
The elongated catheter body generally has an outer tubular element and an inner tubular element coaxially disposed within the outer tubular element with the distal ends of ~hese tubular members sealingly bonded together to prevent loss o~ therapeutic fluids therefrom. An annular lumen which is defined between the inner and outer tubular element directs therapeutic fluids from an adapter provided on the proximal end of the catheter body to the distal portion thereof having the infusion section. The length of the infusion section in the distal portion of the catheter which is effective in infusing therapeutic fluid may be adjusted prior to or a~ter inserting the catheter into a patient's vascular system.
These adjustments are performed from the proximal end of the catheter which normally extends out of the patient during the vasc~llar procedure.
These and other advantages of the invention will become more apparent from the following detailed descxiption of the invention when taken in conjunction with the accompanying exemplary drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. l is an elevational view partially in section of a drug delivery catheter em~odying features of the invention;
FIG. 2 is an enlaged view of the distal erld of the catheter shown in FIG. 1 partially in section;
FIG. 3 is a transverse cross-sectional view of the catheter shown in FIGo 1 taken along the lines 2-2;
FIG. 4 is an elevational view of another drug delivery catheter embodying features of the invention;

~ 2 ~

FIG. 5 is an enlarged sectional view of the distal end of the catheter shown in FIG. 4 taken along the lines 5-5 shown in FIG. 4;
FIG. 6 is a cross-sectional view of the drug delivery catheter shown in FIG. 3 taken along the lines 6-6; and FIG. 7 is a partial longitudinal view in section of a distal section of a drug delivery system similar to that shown in FIG. 1 with a porous section to discharge fluid through the wall of the catheter.

DETAILED_DESCRIPTION OF THE INVENTION

Reference is made to FIGS. 1-3 which illustrate a catheter assembly for the intravascular delivery of therapeutic fluids. The catheter assembly 10 generally includes an elongated catheter body 11 having an outer tubular element 12 and an inner tubular element 13 concentrically disposed therein, an adapter 14 on the proximal end of the catheter body, and an elongated sheath 1~ mounted for slidable movement on the exterior of the catheter body 11.
The inner and outer tubular elements 13 and 12, respectively, define therebetween an annular lumen 16 for directing treatment fluid to the infusion section 17 in the distal portion of the catheter body 11 wherein fluid flow passageways 18 provided in the wall 19 of the outer tubular element 12. The distal ends of the inner and outer tubular elements ~3 and 12 are sealingly bonded such as by adhesive, heat shrinking, or other suitable means to prevent loss of the treatment fluid therefrom. The inner tubular element 13 is provided with an inner lumen 20 adapted to receive a guidewire (not shown) which facilitates advancing the catheter to the desired vascular site.

2~2 ~

The adapter 14 has a side arm 21 which directs therapeutic fluid to the annular lumen 16 in the catheter body 11. A guidewire would extend through the proximal end 22 of the adapter into the inner lumen 20.
The outer elongated tubular sheath 15 is mounted about the outer tubular element 12 for slidable longitudinal movement thereon. The distal end of the sheath 15 fits the outer tubular element 12 snugly so as to effectively prevent discharge fluid through the blocked passageways. A
tightenable collar 23 is provided on the sheath 15 to fix the relative longitudinal position of the sheath with respect to the outer tubular element. It also seals the proximal end of the sheath to prevent leakage of treatment fluid therefrom.
Radiopaque marker 24 is provided on the distal end of the sheath 15 and radiopa~ue markers 25 and 26 are provided on the proximal and distal ends of the infusion section 17 to be able to fluoroscopically visualize these components when the catheter is inserted into the patient's vasculature.
The passageways or ports 18 are provided through the wall of the distal portion of the outer tubular element 12 between the two markers 25 and 26 to infuse therapeutic fluids at a desired vascular site. The length of the infusion section 17 which is effective in discharging fluid is varied by changing the relative longitudinal position of the distal end of the sheath 15 thereon to accommodate thrombi of various lengths.
In utilizing the invention, the catheter assembly 10 is introduced into the patient's vascular system percutaneously through a guiding catheter with a guidewire slidably disposed within the inner lumen 20 of the inner tubular element 12.
Once the infusion section 17 is properly positione~ within a desired location, the length thereof which is exposed is adjusted by axial movement of the sheath 15 at the proximal end thereof which extends out of the patient. The effective 2~2~

length of the infusion section 17 is preferably the approximate length of the thrombus site to be treated. Other treatment sites of different len~ths can also be subsequently treated by readjusting the effective length of the infusion section in essentially the same manner.
FIGS. 4, 5 and 6 illustrate an alternative catheter assembly 40 which is similar in many respects to the catheter assembly shown in FIGS. 1 and 3. In this embodiment, the catheter body 41 has inner and outer tubular elements 42 and 43. The tubular sheath 45 is slidabl~ mounted within the interior of the outer tubular element 42 and an adapter 44 is provided on the proximal end thereof. The proximal end of the outer tubular element 42 is provided with a tightenable collar 46 which sealingly engages the exterior of the sheath 45 and thereby fixes the relative position between the sheath 45 and the outer tubular element 42.
The proximal ends of the sheath 45 and the inner tubular element 43 are secured to the adapter 44. The side arm 47 of adapter 44 directs treatment fluid through the annular passageway 50 disposed between the inner tubular element 43 and the sheath 45 and/or the outer tubular member 42 to the infusion section 51. The infusion section 51 is provided with fluid flow passageways 52 for infusing treatment fluid through wall 53 in the outer tubular element 42 to the exterior of the catheter body 41. A guidewire (not shown) extends through the proximal end 54 of the adapter 44 into the inner lumen 55 provided in inner tubular element 43.
The embodiment shown in FIGS. 4-6 operates in a similar manner as the catheter assembly shown 'in FIGS. 1 -3 except that the proximal end of the outer tubular element 42 is secured to the exterior of the sheath 45 by means of the collar 46 to fix the relative position therebetween. As the outer tubular element 42 is moved longitudinally over the sheath 45, a greater or lesser number of infusion ports 52 are opened thereby adjusting the effective length of the infusion section 51.
As shown in FIG. 7, the fluid flow passageways 52 and 18 of the prior embodiment may be replaced by porous sections 60 formed of suitable plastic material which allows the passage of the treatment ~luid from the annular lumen 51 to the exterior of the catheter. Indeed, the entire infusion section can be formed from a porous plastic material.
The sheath and the inner and outer tubular elements of the catheter body may be formed from suitable plastic materials, such as polyethylene, polyimide and polyesters such as Hytrel 7246, which is a block copolymer of polybutylene terephthalate and long chain polyester glycols. Hytrel is a trademark of the DuPont company. Porous plastic materials for fluid discharge may be formed from polypropylene.
In the embodiment shown in FIGS. 1-3, the sheath 15 is typically about 90 cm in length with an inner diameter of about 0.059 inch (1.5 mm) and an outer diameter of about 0.065 inch (1.65 mm). The outer tubular element 12 of this embodiment has a length of about 130 cm with an inner diameter of about 0.051 inch (1.3 mm) and an outer diameter of about 0.059 inch (1.5 mm)and the inner tubular element 13 has a length of about 130 cm, an inner diameter of about 0.040 inch (1 mm), and an outer diameter of about 0.047 inch (1.2 mm).
In the embodiment shown in FIGS. 4 6, typically the sheath 45 is about 90 cm in length with an inner diameter oE about 0.051 inch (1.3 mm) and an outer diameter of about 0.055 inch (1.4 mm). The outer tubular element 42 has a length of about 90 cm with an inner diameter of about 0.055 inch (1.4 mm)and an outer diameter of about 0.063 inch (1.6 mm), and the inner tubular element 43 has a length of about 120 cm, an inner diameter of about 0.040 inch (l mm), and an outer diameter of about 0.047 inch (1.2 mm). The dimensions of the components may vary widely, depending upon the vascular use of the catheter.
The infusion seckions 17 and 51 are about 10-30 cm in length, typically about 20, cm with about 30 passageways provided in the wall of the outer members 12 and 42 with effective diameters of about 0.005 inch (0.127 mm).
Preferably the passageways are aligned along the length of the outer tubular element in 3 spirals of 10 passageways each.
If porous plastic materials are employed for fluid discharge, it should have an effective pore size of about 2 to about 20 microns.
The number and effective size of the passageways or porous sections will be determined to a large extent upon the desired flow rate of therapeutic fluids and the pressure thereof in the annular lumen between the inner and outer tubular members which form the catheter body. The typical values given above wexe designed for a flow rate of about 80 cc's per hour at a pressure of about 3 to 10 psi (20,000 to 69,000 Pa). Other ~low rates and pressures may require a different number of passageways and different passageway diameters.
Various modifications and improvements can be made to the present invention. For example, in the preferred embodiments described herein, a single annular lumen is employed to direct treatment fluid to the entire infusion section. However, in order to provide a more uniform delivery of the treatment fluid, the annular lumen may be compartmentalized as described and claimed in copending application Serial No. ~,~D~, o~Y-i filed January 3, 1990 which is hereby incorporated by reference in its entirety. In this modification, each compartment of the annular lumen will supply fluid to a particular set of passageways. Preferably, such lumen compartment has a separate source of treatment fluid~
Other modifications and improvements can be made without departing from the scope of the invention.

Claims (13)

1. A catheter for the intravascular delivery of therapeutic fluid, comprising:
a) an elongated catheter body having an inner lumen extending therein to direct therapeutic fluid from the proximal end thereof to a fluid infusion section in a distal portion thereof having means to pass therapeutic fluid from the inner lumen through the wall of the infusion section to the exterior of the catheter;
b) an adapter on the proximal end of the catheter body for directing therapeutic fluids from a source thereof to the inner lumen in the catheter body; and c) means longitudinally movable with respect to the distal portion of the catheter body to adjust the effective length of the infusion section thereof.
2. The catheter of claim 1 wherein the means to pass fluid through the wall of the infusion section is a plurality of passageways.
3. The catheter of claim 2 wherein the passageways have an effective diameter of about 0.002 to about 0.01 inch.
4. The catheter of claim 3 wherein there are about 20 to about 40 passageways in the infusion section.
5. The catheter of claim 4 wherein the passageways through the wall of the infusion section are disposed spirally along the length of the infusion section.
6. The catheter of claim 5 wherein the passageways extend about one complete revolution about the catheter body.
7. The catheter of claim 6 wherein there are a plurality of spiral lines of passageways.
8. The catheter of claim 1 wherein the means to adjust the effective length of the infusion section is a sheath, the longitudinal movement of which closes or opens fluid flow passageways in the wall of the infusion section.
9. The catheter of claim 1 wherein the means to pass fluid through the wall of the infusion section comprises porous plastic material.
10. The catheter of claim 8 wherein the sheath is disposed on the exterior of the catheter body and has a proximal end with a means to sealingly secure said proximal end to the catheter body.
11. The catheter of claim 10 wherein the catheter body comprises an outer tubular element an inner tubular element concentrically disposed therein which defines therebetween an annular lumen for directing therapeutic fluid to the infusion section.
12 12. The catheter of claim 8 wherein the catheter body comprises an outer tubular element and an inner tubular member concentrically disposed therein and wherein the sheath is disposed on the inner surface of the outer tubular element.
13. The catheter of claim 12 wherein the outer tubular member has on the proximal end thereof means to sealingly engage the exterior of the sheath.
CA002020614A 1989-07-07 1990-07-06 Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid Abandoned CA2020614A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US377,243 1989-07-07
US07/377,243 US4968306A (en) 1989-07-07 1989-07-07 Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid

Publications (1)

Publication Number Publication Date
CA2020614A1 true CA2020614A1 (en) 1991-01-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002020614A Abandoned CA2020614A1 (en) 1989-07-07 1990-07-06 Intravascular catheter having an adjustable length infusion section to deliver therapeutic fluid

Country Status (4)

Country Link
US (1) US4968306A (en)
EP (1) EP0406901A1 (en)
JP (1) JPH03131272A (en)
CA (1) CA2020614A1 (en)

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EP0406901A1 (en) 1991-01-09
JPH03131272A (en) 1991-06-04

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