CA2039471C - Dose indicating injection pen - Google Patents
Dose indicating injection penInfo
- Publication number
- CA2039471C CA2039471C CA002039471A CA2039471A CA2039471C CA 2039471 C CA2039471 C CA 2039471C CA 002039471 A CA002039471 A CA 002039471A CA 2039471 A CA2039471 A CA 2039471A CA 2039471 C CA2039471 C CA 2039471C
- Authority
- CA
- Canada
- Prior art keywords
- syringe
- plunger rod
- liquid
- housing
- indicating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
- A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
- A61M2205/585—Means for facilitating use, e.g. by people with impaired vision by visual feedback having magnification means, e.g. magnifying glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
- A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
- A61M5/502—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe for blocking the piston
Abstract
Two embodiments of a multi-dose syringe both include structure for indicating the selected amount of liquid to be injected. A first element and a second element coupled respectively to the syringe housing and the plunger rod are adapted for calibrated movement with respect to each other, One of the first and second elements includes an outer portion having a dose-indicating scale thereon, and another of the first and second elements surrounding said outer portion includes a window through which only a segment of the dose-indicating scale on said portion is visible, the visible portion indicating the amount of liquid selected for injection.
Description
''' --1- 7~ n~ 4~-DOSE ~DICATING INJECTION PEN
3ac~around o~ t~e Invention The present invention relates generally to devices suitable for use in dispensing a measured amount of liquid material ~rom a container. The invention particularly relates to a hypodermic syringe having the same general appearance as a pen or mechanical pencil which is specifically adapted to provide for multiple measured injections of materials such as insulin or human growth hormone.
Diabetics and others frequently find themselves in situations where the assistance of a health professional is unavailable tQ adn~-inister a subcutaneous or intramuscular injectior~ ~3f a measured amount of a liquid agent. In such situations such persons need to have a low cost syringe which does not require the assistance of a health professional to achieve the desired measure of accuracy. It is often the case that such persons require more than one dose per day, each dose being of a somewhat different volume. Dispensers of this general type are known which have the general appearance of a pen or mechanical pencil. The dispenser is typically large enough to hold several such doses, yet it is small enough to fit conveniently in one's pocket or purse. E~camples of such devices are to be found in U.S. Patents 4,413,760; 4,498,904; and 4,592,745. Additional examples are shown in PCT
International Publications wO 87/02895 and WO 88/07874, and in European Patent ~pplication No. 0 327 910, published August 16, 1989.
B
203~
.,~
.", In devices of this class, a container of the liquid is generally provided having a closed first end adapted to be penetrated by a needle assembly so as to permit the liquid in the container to pass out the closed first end for subcutaneous or intramuscular injection. The second end of the container is generally closed by a piston. To prevent tampering or reuse of the liquid container, the piston is generally designed such that a pushing force can be applied to the piston to reduce the liquid-holding volume of the container, but no feature is presented which would be suitable for pulling on the piston so as to enlarge the liquid-holding volume of the container.
An elongated member in the nature of a plunger rod is received within the housing for e~erting a force on the piston closing the second end of the container.
A means is provided for measuring the distance which the plunger rod travels to determine the decrease in volume of the liquid container which causes the dispensing of the liquid within the container. It has generally been recognized that the dispenser should have some feature which would allow the rod to only travel in a single direction toward the piston thereby preventing any action on the part of the rod which might permit an enlargement of the volume of the liquid container. A
safety cover is generally provided over a needle assembly attached to the closed end of the container.
While the prior art pen-style syringes have met with some success, certain shortcomings have also been observed. In some prior art pens, the adjustment of the ~03~7~
, i",., i" , dose to be injected, once made, cannot be accurately diminished to a smaller value. This results in an unnecessary waste of the medicating liquid within the syringe. In some prior art pens, the indication of dose is difficult to read. Prior art pens have generally required the patient to read two scales and/or to do some computations in order to determine the dosage delivered. Further, many prior art devices are specifically intended for repeated use generally by substitution of containers within the syringe which can contribute to the unethical use of the syringe in connection with non-prescribed substances.
SummarY of the ~nvention ln order to overcome these and other shortcomings of the prior art, a syringe constructed in accordance with the present invention includes a syringe housing, a needle assembly coupled to a distal end of the syringe housinq, and a piston movable within the housing to e~pel liquid from the housing through the needle. A plunger rod having a non-circular cross-section is provided having a distal end in contact with the piston for exerting a force on the piston. An interior surface of the syringe housing includes a non-circular opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing, and means engaging a surface of the plunger rod are provided for preventing movement of the plunger rod away from the needle assembly.
' -~ Q 3 ~
A first element and a second element are coupled respectively to the syringe housing and the plunger rod and are adapted for calibrated movement with respect to each other. One of the first and second elements includes an outer portion having a dose-indicating scale thereon. Another of the first and second elements comprising means surrounding said outer portion includes a window through which only some of the dose-indicating scale on said portion is visible, the visible portion completely and unambiguously indicating the amount of liquid selected for injection.
Thus, in pens constructed in accordance with the present invention, the patient needs only to read the scale situated in the window to determine the dosage to be delivered. No consideration of multiple scales or computation is required to determine the dosage.
Two specific embodiments illustrative of the present invention are presented. rn one embodiment, a collar coupled by threads to the syringe housing is selectively adjustable to vary the desired dosage.
Indicia in the form of a dose-indicating scale situated on the collar is hidden by a cap fixed to the plunger rod. A window in the cap permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected. In this embodiment of the invention, as the liquid is repeatedly dispensed from the syringe, the overall length of the pen diminishes.
In the second illustrated embodiment a collar is rotatably coupled to, but is not longitudinally adjustable with respect to, the syringe housing. A
~3~3 ~ P
".1~_' ' ~,.....
hollow cap coupled by threads to the plunger rod is selectively adjustable to vary the desired dosage.
Indicia in the form of a dose-indicating scale situated on the cap is hidden by the collar escept for a window in the collar which permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected. In this embodiment of the invention, the overall length of the pen remains substantially unchanged with repeated use.
In both embodiments, the window can include a lens to enhance the image of the scale. Additionally, both embodiments provide a feature permitting a zeroing of the scale prior to the selected adjustment resulting in the desired dosage. The devices as a whole can be constructed ~rom inexpensive materials and are adapted for machine assembly which contributes directly to a very low manufacturing cost thereby permitting the devices to be disposable. The adjustment of the dose can be increased and decreased thereby diminishing any waste of the medicating liquid. Importantly, the dose indication feature is simply and directly read thereby providing for a more accurate and cost effective use of the medicating liquid dispensed from the apparatus.
Additional features and advantages will become apparent to those skilled in the art from the following detailed discussion of preferred embodiments esemplifying the best mode of carrying out the invention as presently perceived. The detailed description particularly refers to the accompanying drawings.
-6- ~ n ~
3rief DescriPtion of the ~rawinqs Fig. 1 is a front elevation view of a first embodiment of the invention.
Fig. 2 is an enlarged sectional detail taken along line 2-2 of Fig. 1 partially broken away.
Fig. 3 is a dead sectional view taken through line 3-3 of Fig. 2.
Fig. 4 is a plan view of the dose-indicating scale used in the first embodiment.
Fig. S is an front elevation view of a second embodiment of the present invention partially broken away.
Fig. 6 is a sectional detail view taken along lines 6-6 of Fig. 5.
lS Fig. 7 is a view of the left end of the embodiment shown in Fig. 5 with the collar rotated with respect to the cap.
Fig. 8 is a sectional view taken through line 8-8 of Fig. 6.
Fig. 9 is a sectional view taken through line 9-9 of Fig. 6.
Fig. 10 is a plan view from the right side of Fig. 6 of the push-washer.
Fig. 11 is a plan view of the dose-indicating scale used in connection with the second embodiment of the invention.
Fig. 12 (located on the first sheet of drawings, with Figs. 1-4) is a sectional view of a lens incorporated into a window of either embodiment of the invention.
.~
S~ ~, DescriP~ion of ~he Preferred Embodiments A syringe 20 is shown in Fig. 1 to be constructed to include a pocket clip 22 and to otherwise have the general appearance of a pen or mechanical pencil. The syringe 20 includes a syringe housing 24 which holds within it a container 26 containing a liquid. A needle assembly 28 is coupled to a distal end 30 of the housing 24 and includes a removable protective cover 32. An overcap 34, shown to be transparent in Fig. 1, is provided which envelops the syringe housing 24, needle asse~bly 28, and protective cover 32.
The pro~imal end 36 of overcap 34 is coupled to the distal end 38 of collar 40. Collar 40 is shown in Fig. 2 to be unitary with clip 22. The collar 40 includes an interior threaded surface 42 which engages the proximal end 44 of syringe housing 24 thereby permitting relative movement between the syringe housing 24 and the collar 40. A piston 46 is situated within the container 26 so as to expel the contained liquid through the needle 48.
A plunger rod 50 includes a distal end 52 which contacts the piston 46 for exerting a liquid dispensing force on the piston. The plunger rod 50 is shown in Fig. 3 in cross section to have a non-round exterior configuration. A retainer 54 is fixed within the syringe housing 24 at a fixed rotational position and includes an interior surface having a configuration matching the exterior surface of plunger rod 50 to prevent relative rotation between the plunger rod 50 and the syringe housing 24. A push-washer 56 is sandwiched between retainer 54 and container 26 and engages the surface of plunger rod as shown in Fig. 3 to prevent movement of the plunger rod 50 away from the needle S assembly 28. This ensures that the only motion available for the plunger rod 50 is one which will cause liquid to be dispensed from the container 26.
The prozimal end 58 of plunger rod S0 includes an integral cap 60. The cap includes a window 62. The window 62 overlies element 64 which carries on an outer surface a pattern of indicia forming a dose-indicating scale 66 as shown in Fig. 4. The element 64 is frictionally engaged to collar 40 and generally moves with collar 40 relative to cap 60.
In operation, the syringe 20 initially appears as shown in FIg. 1. To dispense a desired amount of liquid from the syringe 20, the overcap 34 is removed from the syringe telescopically to the right of Fig. 1.
The collar 40 is then rotated in the direction of arrow A thereby causing displacement of the collar 40 azially toward the right. As this rotational and az1al displacement of collar 40 occurs with respect to the syringe housing 24, through the interaction of the interior threaded surface 42 and the syringe housing prosimal end 44, the cap 60 is effectively displaced both rotationally and asially in the direction of arrow 8 toward the position shown in phantom at the estreme left of Fig. 2.
As this displacement occurs, the segment of the dose-indicating scale 66 which is visible through G;7 ~ ~ Y~
'~...
~indow 62 varies thereby showing a linear increase in the numbers illustrated in Fig. 4 to indicate an increasing dosage of liquid to be dispensed. The desired dosage can thereby be selected by viewing the dose-indicatinq scale through the window 62. It is to be noted that the collar 40 is free to rotate in either direction thereby permitting both upward and downward adjustment of the dosage should the desired dosage ~e inadvertently be passed during the act of adjustment.
Once the desired dosage is selected, the protective cover 32 is removed from the needle assembly 28 and the needle 48 is situated for appropriate subcutaneous or intramusculear injection of the liquid contained within container 26. Once the needle 48 is appropriately positioned, a force is applied to the end of cap 60 causing a linear displacement of the cap, integral plunger rod 50, and piston 46 toward the right to dispense the liquid from the container 26. The dispensing displacement of the plunger rod 50 is halted by the abutting contact between cap 60 and element 64.
Once the desired amount of liquid has been dispensed from the syringe 20, the needle 48 is removed from the injection position and the protective cap 32 replaced. The overcap 34 is also then replaced.
Finally, element 64 can be forcibly rotated with respect to collar 40 until the scale "0~ appears in the window 62. It is to be noted that with each successive use of a syringe 20, the syringe housing 24 retreats further within the collar 40 which gives the user of 3 ~ 1 4 ~ ~
such a dispensing pen a rough visual indication of the amount of liquid remaininq in the syringe.
~ n a second preferred embodiment, a syringe 70 according to the present invention shown in Fig. 5 et se~. includes a pocket clip 72 and otherwise has the general appearance of a pen or mechanical pencil. In syringe 70, the pocket clip 72 is formed as part of overcap 74 which is slidably received over syringe housing 76. The syringe housing 76 includes a container 78 of liquid to be dispensed through needle 80 of needle assembly 82, the needle assembly including a protective cover 84 similar to that of syringe 20. The container 78 includes a piston 86 which when displaced to the right of Fig. 6 causes the liquid within the container 78 to be e~pelled through the needle 80.
A plunger rod 88 includes a distal end 90 contacting piston 86. The plunger rod 88 includes a spiral outer surface 92 interrupted by a pair of longitudinal channels 94 and 96 which are best illustrated in Figs. 8 and 9. The syringe housing 76 includes a pair of inwardly projecting fingers 98 and 100 engaged in slots or channels 94 and 96 to prevent rotation of the plunger rod 88 with respect to the syringe housing 76. A push-nut 102, as shown in Fig. 10, is sandwiched between the distal surfaces of fingers 98 and 100 and the pro~imal end of container 78. The inwardly projecting prongs 104 on the push-nut 102 project into slots or channels 94 and 96 to engage the base of each channel preventing movement of the plunger rod 88 away from the needle assembly 82.
.,=,_,.
A hollow cap 106 envelops the plunger rod 88 and is engaged with the spiral surface 92 of the plunger rod 88 by an inwardly threaded portion 108 near the distal end of the cap 106. The cap 106 includes an externally serrated portion 110 which interacts with a projecting finger 112 of syringe housing 76 to create a sensible vibration in the event of rotation of the cap 106 relative to the syringe housing 76. An outer portion of the cap 114 carries indicia forming a dose-indicating scale 116 as shown in Fig. 11.
A collar 118 is mounted to the syrinqe housing 76 by detent 120 and is rotatable with respect to the housing 76. The collar envelops all but a projecting portion 122 of cap 106. A window 124 in collar 118 permits visual inspection of a limited portion of the scale 116 carried by the outer portion 114 of cap 106. Both cap 106 and collar 118 include a surface feature 126 and 128, respectively, for zeroing the collar 118 with respect to the cap 106.
In operation, one seeking to use syringe 70 to inject a selected amount of liquid first rotates collar 118 with respect to syringe housing 76 to a position where a double-zero scale is visible through window 124 as shown in Fig. 5. The collar and cap are designed so that this zeroing of scale 116 is automatically achieved by rotating collar 118 with respect to syringe housing 76 until the surface features 126 and 128 are aligned as shown in Fig. 5.
The projecting portion 122 of cap 106 is then rotated with respect to the syringe housing 76. This '?
"~_ rotation of the cap 106 causes the cap to ride up the threads 92 of plunger rod 88 thereby moving a~ially to the left as shown in Figs. 5 and 6. The rotation also causes the portion of scale 116 visible through window 124 to be modified with the scale numbers increasing as in the first em~odiment. The rotation of cap 106 with respect to syringe housing 76 also causes finger 1~2 to ride over the grooves of the serrated surface 110 causing a sensible movement of the finger 112. By dimensioning the grooves appropriately, the number of grooves traversed by finger 112 can match the scale visible through window 124. The sensible movement of the flexible finger 112 coupled with the initial zeroing achieved by the co-alignment of surface features 126 and 128 permits use of the syringe 70 by a visually impaired person.
At such time as the scale for the desired dosage is achieved in window 124, the overcap 74 can be removed from the syringe 70. The protective cover 84 can also be removed from the needle 80 and the needle appropriately placed for injection. Pressure is then applied to the end of cap 106 causing it to move axially with the plunger rod 88 toward the needle assembly 82.
The movement of the plunger rod forces piston 86 to e~pel liquid from the liquid container 78 through the needle 80. Movement of the cap 106 and plunger rod 88 is terminated by the abutment between the cap 106 and syringe housing 76 at stop 130. During such axial movement of cap 106, the projecting finger 112 slides within a single groove 110 thereby restricting the 4 ~
""
cap 106 from any rotational movement relative to the syringe housing 76 which would cause a modification of the selected dosage.
After the selected dosage has been injected, the needle 80 is removed from its injection position and the protective cover 84 repositioned as shown in Fig. 6. The overcap can then also be replaced. E~cept when the amount selected for injection was 20, 40, or 60 scale units, the relative position between cap 106 and collar 118 will be other than an aligned position and will thus appear something like that shown in Fig. 7.
The collar 118 can now be rotated relative to the syringe housing 76 to the zero position as previously described so that the syringe 70 is ready for a subsequent selection of a measured amount of liquid.
Fig. 12 shows in cross section a window from either embodiment which includes a lens 132 which acts to enlarge the image of the dose-indicating scale.
While only the second illustrated embodiment includes a ~lexible member 112 adapted for a sensible movement during the calibrated adjustment of the syringe, such a feature could be included in syringe 20. Although the invention has been described in detail with reference to the two illustrated preferred embodiments, other variations and modifications exist within the scope and spirit of the invention as described and as defined in the following claims.
3ac~around o~ t~e Invention The present invention relates generally to devices suitable for use in dispensing a measured amount of liquid material ~rom a container. The invention particularly relates to a hypodermic syringe having the same general appearance as a pen or mechanical pencil which is specifically adapted to provide for multiple measured injections of materials such as insulin or human growth hormone.
Diabetics and others frequently find themselves in situations where the assistance of a health professional is unavailable tQ adn~-inister a subcutaneous or intramuscular injectior~ ~3f a measured amount of a liquid agent. In such situations such persons need to have a low cost syringe which does not require the assistance of a health professional to achieve the desired measure of accuracy. It is often the case that such persons require more than one dose per day, each dose being of a somewhat different volume. Dispensers of this general type are known which have the general appearance of a pen or mechanical pencil. The dispenser is typically large enough to hold several such doses, yet it is small enough to fit conveniently in one's pocket or purse. E~camples of such devices are to be found in U.S. Patents 4,413,760; 4,498,904; and 4,592,745. Additional examples are shown in PCT
International Publications wO 87/02895 and WO 88/07874, and in European Patent ~pplication No. 0 327 910, published August 16, 1989.
B
203~
.,~
.", In devices of this class, a container of the liquid is generally provided having a closed first end adapted to be penetrated by a needle assembly so as to permit the liquid in the container to pass out the closed first end for subcutaneous or intramuscular injection. The second end of the container is generally closed by a piston. To prevent tampering or reuse of the liquid container, the piston is generally designed such that a pushing force can be applied to the piston to reduce the liquid-holding volume of the container, but no feature is presented which would be suitable for pulling on the piston so as to enlarge the liquid-holding volume of the container.
An elongated member in the nature of a plunger rod is received within the housing for e~erting a force on the piston closing the second end of the container.
A means is provided for measuring the distance which the plunger rod travels to determine the decrease in volume of the liquid container which causes the dispensing of the liquid within the container. It has generally been recognized that the dispenser should have some feature which would allow the rod to only travel in a single direction toward the piston thereby preventing any action on the part of the rod which might permit an enlargement of the volume of the liquid container. A
safety cover is generally provided over a needle assembly attached to the closed end of the container.
While the prior art pen-style syringes have met with some success, certain shortcomings have also been observed. In some prior art pens, the adjustment of the ~03~7~
, i",., i" , dose to be injected, once made, cannot be accurately diminished to a smaller value. This results in an unnecessary waste of the medicating liquid within the syringe. In some prior art pens, the indication of dose is difficult to read. Prior art pens have generally required the patient to read two scales and/or to do some computations in order to determine the dosage delivered. Further, many prior art devices are specifically intended for repeated use generally by substitution of containers within the syringe which can contribute to the unethical use of the syringe in connection with non-prescribed substances.
SummarY of the ~nvention ln order to overcome these and other shortcomings of the prior art, a syringe constructed in accordance with the present invention includes a syringe housing, a needle assembly coupled to a distal end of the syringe housinq, and a piston movable within the housing to e~pel liquid from the housing through the needle. A plunger rod having a non-circular cross-section is provided having a distal end in contact with the piston for exerting a force on the piston. An interior surface of the syringe housing includes a non-circular opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing, and means engaging a surface of the plunger rod are provided for preventing movement of the plunger rod away from the needle assembly.
' -~ Q 3 ~
A first element and a second element are coupled respectively to the syringe housing and the plunger rod and are adapted for calibrated movement with respect to each other. One of the first and second elements includes an outer portion having a dose-indicating scale thereon. Another of the first and second elements comprising means surrounding said outer portion includes a window through which only some of the dose-indicating scale on said portion is visible, the visible portion completely and unambiguously indicating the amount of liquid selected for injection.
Thus, in pens constructed in accordance with the present invention, the patient needs only to read the scale situated in the window to determine the dosage to be delivered. No consideration of multiple scales or computation is required to determine the dosage.
Two specific embodiments illustrative of the present invention are presented. rn one embodiment, a collar coupled by threads to the syringe housing is selectively adjustable to vary the desired dosage.
Indicia in the form of a dose-indicating scale situated on the collar is hidden by a cap fixed to the plunger rod. A window in the cap permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected. In this embodiment of the invention, as the liquid is repeatedly dispensed from the syringe, the overall length of the pen diminishes.
In the second illustrated embodiment a collar is rotatably coupled to, but is not longitudinally adjustable with respect to, the syringe housing. A
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hollow cap coupled by threads to the plunger rod is selectively adjustable to vary the desired dosage.
Indicia in the form of a dose-indicating scale situated on the cap is hidden by the collar escept for a window in the collar which permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected. In this embodiment of the invention, the overall length of the pen remains substantially unchanged with repeated use.
In both embodiments, the window can include a lens to enhance the image of the scale. Additionally, both embodiments provide a feature permitting a zeroing of the scale prior to the selected adjustment resulting in the desired dosage. The devices as a whole can be constructed ~rom inexpensive materials and are adapted for machine assembly which contributes directly to a very low manufacturing cost thereby permitting the devices to be disposable. The adjustment of the dose can be increased and decreased thereby diminishing any waste of the medicating liquid. Importantly, the dose indication feature is simply and directly read thereby providing for a more accurate and cost effective use of the medicating liquid dispensed from the apparatus.
Additional features and advantages will become apparent to those skilled in the art from the following detailed discussion of preferred embodiments esemplifying the best mode of carrying out the invention as presently perceived. The detailed description particularly refers to the accompanying drawings.
-6- ~ n ~
3rief DescriPtion of the ~rawinqs Fig. 1 is a front elevation view of a first embodiment of the invention.
Fig. 2 is an enlarged sectional detail taken along line 2-2 of Fig. 1 partially broken away.
Fig. 3 is a dead sectional view taken through line 3-3 of Fig. 2.
Fig. 4 is a plan view of the dose-indicating scale used in the first embodiment.
Fig. S is an front elevation view of a second embodiment of the present invention partially broken away.
Fig. 6 is a sectional detail view taken along lines 6-6 of Fig. 5.
lS Fig. 7 is a view of the left end of the embodiment shown in Fig. 5 with the collar rotated with respect to the cap.
Fig. 8 is a sectional view taken through line 8-8 of Fig. 6.
Fig. 9 is a sectional view taken through line 9-9 of Fig. 6.
Fig. 10 is a plan view from the right side of Fig. 6 of the push-washer.
Fig. 11 is a plan view of the dose-indicating scale used in connection with the second embodiment of the invention.
Fig. 12 (located on the first sheet of drawings, with Figs. 1-4) is a sectional view of a lens incorporated into a window of either embodiment of the invention.
.~
S~ ~, DescriP~ion of ~he Preferred Embodiments A syringe 20 is shown in Fig. 1 to be constructed to include a pocket clip 22 and to otherwise have the general appearance of a pen or mechanical pencil. The syringe 20 includes a syringe housing 24 which holds within it a container 26 containing a liquid. A needle assembly 28 is coupled to a distal end 30 of the housing 24 and includes a removable protective cover 32. An overcap 34, shown to be transparent in Fig. 1, is provided which envelops the syringe housing 24, needle asse~bly 28, and protective cover 32.
The pro~imal end 36 of overcap 34 is coupled to the distal end 38 of collar 40. Collar 40 is shown in Fig. 2 to be unitary with clip 22. The collar 40 includes an interior threaded surface 42 which engages the proximal end 44 of syringe housing 24 thereby permitting relative movement between the syringe housing 24 and the collar 40. A piston 46 is situated within the container 26 so as to expel the contained liquid through the needle 48.
A plunger rod 50 includes a distal end 52 which contacts the piston 46 for exerting a liquid dispensing force on the piston. The plunger rod 50 is shown in Fig. 3 in cross section to have a non-round exterior configuration. A retainer 54 is fixed within the syringe housing 24 at a fixed rotational position and includes an interior surface having a configuration matching the exterior surface of plunger rod 50 to prevent relative rotation between the plunger rod 50 and the syringe housing 24. A push-washer 56 is sandwiched between retainer 54 and container 26 and engages the surface of plunger rod as shown in Fig. 3 to prevent movement of the plunger rod 50 away from the needle S assembly 28. This ensures that the only motion available for the plunger rod 50 is one which will cause liquid to be dispensed from the container 26.
The prozimal end 58 of plunger rod S0 includes an integral cap 60. The cap includes a window 62. The window 62 overlies element 64 which carries on an outer surface a pattern of indicia forming a dose-indicating scale 66 as shown in Fig. 4. The element 64 is frictionally engaged to collar 40 and generally moves with collar 40 relative to cap 60.
In operation, the syringe 20 initially appears as shown in FIg. 1. To dispense a desired amount of liquid from the syringe 20, the overcap 34 is removed from the syringe telescopically to the right of Fig. 1.
The collar 40 is then rotated in the direction of arrow A thereby causing displacement of the collar 40 azially toward the right. As this rotational and az1al displacement of collar 40 occurs with respect to the syringe housing 24, through the interaction of the interior threaded surface 42 and the syringe housing prosimal end 44, the cap 60 is effectively displaced both rotationally and asially in the direction of arrow 8 toward the position shown in phantom at the estreme left of Fig. 2.
As this displacement occurs, the segment of the dose-indicating scale 66 which is visible through G;7 ~ ~ Y~
'~...
~indow 62 varies thereby showing a linear increase in the numbers illustrated in Fig. 4 to indicate an increasing dosage of liquid to be dispensed. The desired dosage can thereby be selected by viewing the dose-indicatinq scale through the window 62. It is to be noted that the collar 40 is free to rotate in either direction thereby permitting both upward and downward adjustment of the dosage should the desired dosage ~e inadvertently be passed during the act of adjustment.
Once the desired dosage is selected, the protective cover 32 is removed from the needle assembly 28 and the needle 48 is situated for appropriate subcutaneous or intramusculear injection of the liquid contained within container 26. Once the needle 48 is appropriately positioned, a force is applied to the end of cap 60 causing a linear displacement of the cap, integral plunger rod 50, and piston 46 toward the right to dispense the liquid from the container 26. The dispensing displacement of the plunger rod 50 is halted by the abutting contact between cap 60 and element 64.
Once the desired amount of liquid has been dispensed from the syringe 20, the needle 48 is removed from the injection position and the protective cap 32 replaced. The overcap 34 is also then replaced.
Finally, element 64 can be forcibly rotated with respect to collar 40 until the scale "0~ appears in the window 62. It is to be noted that with each successive use of a syringe 20, the syringe housing 24 retreats further within the collar 40 which gives the user of 3 ~ 1 4 ~ ~
such a dispensing pen a rough visual indication of the amount of liquid remaininq in the syringe.
~ n a second preferred embodiment, a syringe 70 according to the present invention shown in Fig. 5 et se~. includes a pocket clip 72 and otherwise has the general appearance of a pen or mechanical pencil. In syringe 70, the pocket clip 72 is formed as part of overcap 74 which is slidably received over syringe housing 76. The syringe housing 76 includes a container 78 of liquid to be dispensed through needle 80 of needle assembly 82, the needle assembly including a protective cover 84 similar to that of syringe 20. The container 78 includes a piston 86 which when displaced to the right of Fig. 6 causes the liquid within the container 78 to be e~pelled through the needle 80.
A plunger rod 88 includes a distal end 90 contacting piston 86. The plunger rod 88 includes a spiral outer surface 92 interrupted by a pair of longitudinal channels 94 and 96 which are best illustrated in Figs. 8 and 9. The syringe housing 76 includes a pair of inwardly projecting fingers 98 and 100 engaged in slots or channels 94 and 96 to prevent rotation of the plunger rod 88 with respect to the syringe housing 76. A push-nut 102, as shown in Fig. 10, is sandwiched between the distal surfaces of fingers 98 and 100 and the pro~imal end of container 78. The inwardly projecting prongs 104 on the push-nut 102 project into slots or channels 94 and 96 to engage the base of each channel preventing movement of the plunger rod 88 away from the needle assembly 82.
.,=,_,.
A hollow cap 106 envelops the plunger rod 88 and is engaged with the spiral surface 92 of the plunger rod 88 by an inwardly threaded portion 108 near the distal end of the cap 106. The cap 106 includes an externally serrated portion 110 which interacts with a projecting finger 112 of syringe housing 76 to create a sensible vibration in the event of rotation of the cap 106 relative to the syringe housing 76. An outer portion of the cap 114 carries indicia forming a dose-indicating scale 116 as shown in Fig. 11.
A collar 118 is mounted to the syrinqe housing 76 by detent 120 and is rotatable with respect to the housing 76. The collar envelops all but a projecting portion 122 of cap 106. A window 124 in collar 118 permits visual inspection of a limited portion of the scale 116 carried by the outer portion 114 of cap 106. Both cap 106 and collar 118 include a surface feature 126 and 128, respectively, for zeroing the collar 118 with respect to the cap 106.
In operation, one seeking to use syringe 70 to inject a selected amount of liquid first rotates collar 118 with respect to syringe housing 76 to a position where a double-zero scale is visible through window 124 as shown in Fig. 5. The collar and cap are designed so that this zeroing of scale 116 is automatically achieved by rotating collar 118 with respect to syringe housing 76 until the surface features 126 and 128 are aligned as shown in Fig. 5.
The projecting portion 122 of cap 106 is then rotated with respect to the syringe housing 76. This '?
"~_ rotation of the cap 106 causes the cap to ride up the threads 92 of plunger rod 88 thereby moving a~ially to the left as shown in Figs. 5 and 6. The rotation also causes the portion of scale 116 visible through window 124 to be modified with the scale numbers increasing as in the first em~odiment. The rotation of cap 106 with respect to syringe housing 76 also causes finger 1~2 to ride over the grooves of the serrated surface 110 causing a sensible movement of the finger 112. By dimensioning the grooves appropriately, the number of grooves traversed by finger 112 can match the scale visible through window 124. The sensible movement of the flexible finger 112 coupled with the initial zeroing achieved by the co-alignment of surface features 126 and 128 permits use of the syringe 70 by a visually impaired person.
At such time as the scale for the desired dosage is achieved in window 124, the overcap 74 can be removed from the syringe 70. The protective cover 84 can also be removed from the needle 80 and the needle appropriately placed for injection. Pressure is then applied to the end of cap 106 causing it to move axially with the plunger rod 88 toward the needle assembly 82.
The movement of the plunger rod forces piston 86 to e~pel liquid from the liquid container 78 through the needle 80. Movement of the cap 106 and plunger rod 88 is terminated by the abutment between the cap 106 and syringe housing 76 at stop 130. During such axial movement of cap 106, the projecting finger 112 slides within a single groove 110 thereby restricting the 4 ~
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cap 106 from any rotational movement relative to the syringe housing 76 which would cause a modification of the selected dosage.
After the selected dosage has been injected, the needle 80 is removed from its injection position and the protective cover 84 repositioned as shown in Fig. 6. The overcap can then also be replaced. E~cept when the amount selected for injection was 20, 40, or 60 scale units, the relative position between cap 106 and collar 118 will be other than an aligned position and will thus appear something like that shown in Fig. 7.
The collar 118 can now be rotated relative to the syringe housing 76 to the zero position as previously described so that the syringe 70 is ready for a subsequent selection of a measured amount of liquid.
Fig. 12 shows in cross section a window from either embodiment which includes a lens 132 which acts to enlarge the image of the dose-indicating scale.
While only the second illustrated embodiment includes a ~lexible member 112 adapted for a sensible movement during the calibrated adjustment of the syringe, such a feature could be included in syringe 20. Although the invention has been described in detail with reference to the two illustrated preferred embodiments, other variations and modifications exist within the scope and spirit of the invention as described and as defined in the following claims.
Claims (13)
1. A syringe for containing a liquid to be injected including means for selectively adjusting the amount of liquid to be injected and means for indicating the amount selected, comprising:
a syringe housing, a piston movable within the housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a first element and a second element coupled respectively to the syringe housing and the plunger rod and capable of calibrated movement with respect to each other, one of the first and second elements including an outer portion having a dose-indicating scale thereon, and another of the first and second elements comprising means surrounding said outer portion including a window through which only a segment of the dose-indicating scale on said portion is visible, the visible segment indicating the amount of liquid selected for injection.
a syringe housing, a piston movable within the housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a first element and a second element coupled respectively to the syringe housing and the plunger rod and capable of calibrated movement with respect to each other, one of the first and second elements including an outer portion having a dose-indicating scale thereon, and another of the first and second elements comprising means surrounding said outer portion including a window through which only a segment of the dose-indicating scale on said portion is visible, the visible segment indicating the amount of liquid selected for injection.
2. A syringe according to claim 1 further comprising rotation preventing means within the syringe housing for preventing rotation of the plunger rod with respect to the syringe housing.
3. A syringe according to claim 2 wherein the rotation preventing means comprises an interior surface of the syringe housing having a non-cylindrical opening corresponding generally to a cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing.
4. A syringe according to claim 1 further comprising a needle assembly coupled to a distal end of the syringe housing; and prevention means engaging a surface of the plunger rod for preventing movement of the plunger rod away from the needle assembly.
5. A syringe according to claim 4 further comprising stop means means surrounding the plunger rod for stopping movement of the second element toward the needle assembly upon injection of the selected amount of liquid.
6. The syringe of claim 4 further comprising a container of liquid situated within the syringe housing, said prevention means contacting a proximal end of the container of liquid for maintaining the container in fixed position with respect to the syringe housing.
7. The syringe of claim 2 further comprising rotation preventing means within the syringe housing for preventing rotation of the plunger rod with respect to the syringe housing, the rotation preventing means including prevention means engaging a surface of the plunger rod for preventing movement of the plunger rod away from a distal end of the syringe housing.
8. A syringe according to claim 1 wherein the first element comprises a collar including means for movably engaging the collar to the syringe housing, and wherein the window further comprises a lens for enlarging the appearance of the visible portion of the dose-indicating scale.
9. A syringe according to claim 8 wherein the second element comprises a cap coupled to the plunger rod, the cap including said window and lens through which said dose-indicating scale is visible.
10. A syringe according to claim 8 wherein the second element comprises a cap coupled to the plunger rod, the cap including said dose-indicating scale on an outer portion thereof, only a segment of the dose-indicating scale being visible through said window and lens in said collar.
11. A syringe for containing a liquid to be injected including means for selectively adjusting the amount of liquid to be injected and means for indicating the amount selected, comprising:
a syringe housing, a piston movable within the housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a collar including a threaded coupling coupled to the syringe housing for calibrated adjustment of the collar relative thereto, the collar including an outer portion having a dose-indicating scale thereon; and a hollow cap fixed to the plunger rod, an outer portion of the cap overlying the outer portion of the collar and having a window through which only a segment of the dose-indicating scale on said portion of the collar is visible, the visible portion indicating the amount of liquid selected for injection.
a syringe housing, a piston movable within the housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a collar including a threaded coupling coupled to the syringe housing for calibrated adjustment of the collar relative thereto, the collar including an outer portion having a dose-indicating scale thereon; and a hollow cap fixed to the plunger rod, an outer portion of the cap overlying the outer portion of the collar and having a window through which only a segment of the dose-indicating scale on said portion of the collar is visible, the visible portion indicating the amount of liquid selected for injection.
12. A syringe for containing a liquid to be injected including means for selectively adjusting the amount of liquid to be injected and means for indicating the amount selected, comprising:
a syringe housing, a piston movable within the syringe housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a hollow cap enveloping a second end of the plunger rod end opposite the first end including means for calibrated adjustment of the cap relative to the plunger, an outer portion of the cap having a dose-indicating scale thereon for indicating calibrated movement of the cap with respect to the plunger rod; and a collar surrounding a distal end of the hollow cap and rotatably coupled to the syringe housing, the collar including a window through which only a segment of the dose-indicating scale on said portion of the cap is visible, the visible portion indicating the amount of liquid selected for injection.
a syringe housing, a piston movable within the syringe housing to expel the liquid, and a plunger rod having a first end in contact with the piston for exerting a force on the piston;
a hollow cap enveloping a second end of the plunger rod end opposite the first end including means for calibrated adjustment of the cap relative to the plunger, an outer portion of the cap having a dose-indicating scale thereon for indicating calibrated movement of the cap with respect to the plunger rod; and a collar surrounding a distal end of the hollow cap and rotatably coupled to the syringe housing, the collar including a window through which only a segment of the dose-indicating scale on said portion of the cap is visible, the visible portion indicating the amount of liquid selected for injection.
13. A syringe for containing a liquid to be injected including means for selectively adjusting the amount of liquid to be injected and means for indicating the amount selected, comprising:
a syringe housing, a needle assembly coupled to a distal end of the syringe housing, a piston movable within the housing to expel liquid from the housing through the needle, a plunger rod having a non-circular cross-section and a distal end in contact with the piston for exerting a force on the piston, an interior surface of the syringe housing having a non-circular opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing, and means engaging a surface of the plunger rod for preventing movement of the plunger rod away from the needle assembly;
a first element and a second element coupled respectively to the syringe housing and the plunger rod and adapted for calibrated movement with respect to each other, one of the first and second elements including an outer portion having a dose-indicating scale thereon, and another of the first and second elements comprising means surrounding said outer portion including a window through which only a segment of the dose-indicating scale on said portion is visible, the visible portion indicating the amount of liquid selected for injection.
a syringe housing, a needle assembly coupled to a distal end of the syringe housing, a piston movable within the housing to expel liquid from the housing through the needle, a plunger rod having a non-circular cross-section and a distal end in contact with the piston for exerting a force on the piston, an interior surface of the syringe housing having a non-circular opening corresponding generally to the cross-section of the plunger rod for preventing rotation of the plunger rod with respect to the housing, and means engaging a surface of the plunger rod for preventing movement of the plunger rod away from the needle assembly;
a first element and a second element coupled respectively to the syringe housing and the plunger rod and adapted for calibrated movement with respect to each other, one of the first and second elements including an outer portion having a dose-indicating scale thereon, and another of the first and second elements comprising means surrounding said outer portion including a window through which only a segment of the dose-indicating scale on said portion is visible, the visible portion indicating the amount of liquid selected for injection.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/504,254 | 1990-04-04 | ||
| US07/504,254 US5226896A (en) | 1990-04-04 | 1990-04-04 | Dose indicating injection pen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2039471A1 CA2039471A1 (en) | 1991-10-05 |
| CA2039471C true CA2039471C (en) | 1998-12-08 |
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ID=24005496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002039471A Expired - Fee Related CA2039471C (en) | 1990-04-04 | 1991-03-28 | Dose indicating injection pen |
Country Status (23)
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| US (2) | US5226896A (en) |
| EP (1) | EP0450905B1 (en) |
| JP (1) | JPH066159B2 (en) |
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Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671729A1 (en) * | 1991-01-17 | 1992-07-24 | Micro Dose Pharma | DEVICE FOR DELIVERING CONTROLLED DOSES, PARTICULARLY OF THE DISPOSABLE INSULIN SYRINGE TYPE. |
| US5298023A (en) * | 1991-03-08 | 1994-03-29 | Habley Medical Technology Corporation | Multiple pharmaceutical dispenser with accumulator |
| DE4112259A1 (en) * | 1991-04-15 | 1992-10-22 | Medico Dev Investment Co | INJECTION DEVICE |
| DK134691D0 (en) * | 1991-07-12 | 1991-07-12 | Novo Nordisk As | APPARATUS |
| DK175491D0 (en) * | 1991-10-18 | 1991-10-18 | Novo Nordisk As | APPARATUS |
| SE9103215D0 (en) * | 1991-11-04 | 1991-11-04 | Kabi Pharmacia Ab | A METHOD AND DEVICE FOR DOSING A LIQUID PREPARATION |
| US5328486A (en) * | 1991-11-19 | 1994-07-12 | American Cyanamid Company | Syringe for dispensing multiple dosages |
| DK194291D0 (en) * | 1991-11-29 | 1991-11-29 | Novo Nordisk As | SPRAY FOR AUTOMATIC INJECTION. |
| FR2684880B1 (en) * | 1991-12-17 | 1994-03-25 | Micro Dose Pharma | MECHANICAL DEVICE WITH DISPLAY OF A VISUAL INDICATION, SUCH AS A GRADUATION. |
| CH682806A5 (en) * | 1992-02-21 | 1993-11-30 | Medimpex Ets | Injection device. |
| CH682805A5 (en) * | 1992-02-24 | 1993-11-30 | Medimpex Ets | Display device for an injection device. |
| GB9219849D0 (en) * | 1992-09-19 | 1992-10-28 | Hypoguard Uk Ltd | Device |
| US5391157A (en) * | 1992-10-20 | 1995-02-21 | Eli Lilly And Company | End of dose indicator |
| US5545147A (en) * | 1992-10-20 | 1996-08-13 | Eli Lilly And Company | Anti-backup improvement for hypodermic syringes |
| US5378233A (en) * | 1992-11-18 | 1995-01-03 | Habley Medical Technology Corporation | Selected dose pharmaceutical dispenser |
| US5584815A (en) * | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
| US5472022A (en) * | 1993-11-02 | 1995-12-05 | Genentech, Inc. | Injection pen solution transfer apparatus and method |
| ES2070782B1 (en) * | 1993-11-05 | 1995-12-16 | Vita Invest Sa | IMPROVEMENTS IN SELF-INJECTABLE EQUIPMENT. |
| US5514097A (en) * | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
| US5536249A (en) * | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
| US5725508A (en) * | 1994-06-22 | 1998-03-10 | Becton Dickinson And Company | Quick connect medication delivery pen |
| IL114767A (en) * | 1994-07-27 | 1998-12-06 | Survival Technology | Nipple plunger |
| AU696439B2 (en) | 1995-03-07 | 1998-09-10 | Eli Lilly And Company | Recyclable medication dispensing device |
| US5651775A (en) | 1995-07-12 | 1997-07-29 | Walker; Richard Bradley | Medication delivery and monitoring system and methods |
| AU1860697A (en) * | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
| US5776103A (en) | 1995-10-11 | 1998-07-07 | Science Incorporated | Fluid delivery device with bolus injection site |
| US5658259A (en) * | 1995-10-19 | 1997-08-19 | Meridian Medical Technologies, Inc. | Dental cartridge assembly auto-injector with protective needle cover |
| US5741242A (en) * | 1995-12-22 | 1998-04-21 | Science Incorporated | Infusion device with fill assembly |
| EP0828527B1 (en) * | 1996-04-02 | 2002-07-31 | Disetronic Licensing AG | Injection device |
| WO1997036625A1 (en) | 1996-04-02 | 1997-10-09 | Disetronic Licensing Ag | Injection device |
| EP0848623B1 (en) | 1996-07-05 | 2003-10-08 | Disetronic Licensing AG | Injection device for injection of liquid |
| DE59611288D1 (en) * | 1996-07-05 | 2005-12-01 | Tecpharma Licensing Ag | INJECTION DEVICE FOR INJECTING LIQUID |
| US6146361A (en) | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
| DE29703820U1 (en) * | 1997-03-03 | 1998-07-02 | Medico Dev Investment Co | Injection device |
| DE19717107B4 (en) | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System of container and drive device for a piston, which is held in the container containing a drug fluid |
| EP1863201A3 (en) * | 1997-04-24 | 2014-03-19 | Ntt Mobile Communications Network Inc. | Method and system for mobile communications |
| DE19723647C1 (en) | 1997-06-05 | 1998-12-24 | Disetronic Licensing Ag | Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| DE19740187C1 (en) * | 1997-09-12 | 1999-04-15 | Disetronic Licensing Ag | Dosing unit, e.g. for medicines |
| ES2140328B1 (en) * | 1997-12-04 | 2000-10-16 | Perez Jose Manuel Prieto | APPLICATOR DEVICE FOR AMPOULES OF INJECTABLE THERAPEUTIC SUBSTANCES. |
| DE19755125B4 (en) | 1997-12-11 | 2006-04-20 | Tecpharma Licensing Ag | Needle protection device for injection devices |
| CA2305634C (en) * | 1998-01-30 | 2006-01-03 | Novo Nordisk A/S | An injection syringe |
| US6001082A (en) * | 1998-02-20 | 1999-12-14 | Becton Dickinson And Company | Medication delivery pen with an integral magnifying pocket clip |
| US6126637A (en) | 1998-04-15 | 2000-10-03 | Science Incorporated | Fluid delivery device with collapsible needle cover |
| US6290679B1 (en) | 1999-05-14 | 2001-09-18 | Disetronic Licensing Ag | Device for metered administration of an injectable product |
| DE19822031C2 (en) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Auto injection device |
| DE19821933C1 (en) * | 1998-05-15 | 1999-11-11 | Disetronic Licensing Ag | Device for administering an injectable product |
| US6689108B2 (en) * | 1998-11-13 | 2004-02-10 | Elan Pharma International Limited | Device for measuring a volume of drug |
| US20040069044A1 (en) * | 1999-04-29 | 2004-04-15 | Gilad Lavi | Device for measuring a volume of drug |
| DE19945397C2 (en) | 1999-09-22 | 2001-07-19 | Disetronic Licensing Ag | Device for the dosed administration of an injectable product |
| US6547763B2 (en) | 2000-05-18 | 2003-04-15 | Novo Nordisk A/S | Dose display for injection device |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| US6986760B2 (en) * | 2000-08-02 | 2006-01-17 | Becton, Dickinson And Company | Pen needle and safety shield system |
| ES2605353T3 (en) * | 2000-08-02 | 2017-03-14 | Becton, Dickinson And Company | Pen needle system and safety shield |
| IL154683A0 (en) * | 2000-10-09 | 2003-09-17 | Lilly Co Eli | Pen device for administration of parathyroid hormone |
| US6899699B2 (en) * | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
| US6673049B2 (en) | 2001-02-15 | 2004-01-06 | Disetronic Licensing Ag | Injection device for injecting fluid |
| SE518708C2 (en) * | 2001-02-28 | 2002-11-12 | Mats Bonniers Sjukvaard Och Ut | Syringe with metering device |
| CA2440983A1 (en) | 2001-03-14 | 2002-09-26 | Penjet Corporation | System and method for removing dissolved gas from a solution |
| US6613010B2 (en) | 2001-04-13 | 2003-09-02 | Penjet Corporation | Modular gas-pressured needle-less injector |
| US20050192530A1 (en) * | 2001-04-13 | 2005-09-01 | Penjet Corporation | Method and apparatus for needle-less injection with a degassed fluid |
| WO2002087663A2 (en) | 2001-04-27 | 2002-11-07 | Penjet Corporation | Method and apparatus for filling or refilling a needle-less injector |
| DE20112501U1 (en) * | 2001-07-30 | 2002-12-19 | Disetronic Licensing Ag | Locking lock for connecting housing parts of an injection or infusion device |
| DE10163327A1 (en) | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Reservoir module with piston rod |
| DE10163326A1 (en) * | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Administration device with dosing device |
| DE10163328B4 (en) | 2001-07-30 | 2005-08-11 | Tecpharma Licensing Ag | Administration device with anti-rotation device |
| DE60213253T2 (en) * | 2001-08-27 | 2007-07-26 | Novo Nordisk A/S | A CARTRIDGE AND A MEDICAL DELIVERY SYSTEM THAT SUCH AS A CARTRIDGE |
| US20040098010A1 (en) * | 2001-10-22 | 2004-05-20 | Glenn Davison | Confuser crown skin pricker |
| US6824526B2 (en) | 2001-10-22 | 2004-11-30 | Penjet Corporation | Engine and diffuser for use with a needle-less injector |
| DE20209051U1 (en) * | 2001-12-21 | 2003-04-24 | Disetronic Licensing Ag | Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop |
| GB0205485D0 (en) * | 2002-03-08 | 2002-04-24 | Dca Design Int Ltd | Improvements in and relating to a medicament delivery service |
| DE10229122B4 (en) | 2002-06-28 | 2006-09-07 | Tecpharma Licensing Ag | Administration device with resettable actuation lock |
| DE10232412A1 (en) * | 2002-07-17 | 2004-02-05 | Disetronic Licensing Ag | Administration device with priming function |
| ES2327731T3 (en) * | 2002-09-24 | 2009-11-03 | Shl Group Ab | INJECTION DEVICE. |
| US7018356B2 (en) | 2002-10-31 | 2006-03-28 | Wise Roger R | Method and apparatus for adjusting the contents of a needle-less injector |
| US6896666B2 (en) * | 2002-11-08 | 2005-05-24 | Kochamba Family Trust | Cutaneous injection delivery under suction |
| US20060264926A1 (en) * | 2002-11-08 | 2006-11-23 | Kochamba Gary S | Cutaneous stabilization by vacuum for delivery of micro-needle array |
| US9205197B2 (en) * | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
| GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| DE10327119A1 (en) | 2003-06-13 | 2004-12-30 | Aventis Pharma Deutschland Gmbh | Injection cap |
| US8932264B2 (en) * | 2003-08-11 | 2015-01-13 | Becton, Dickinson And Company | Medication delivery pen assembly with needle locking safety shield |
| DE20317377U1 (en) † | 2003-11-03 | 2005-03-17 | B D Medico S A R L | injection device |
| US7293803B2 (en) * | 2003-12-16 | 2007-11-13 | Ching-Nan Chu | Method for indicating the user's name on a blood-sampling needle pen and the product thereof |
| JP4922172B2 (en) | 2004-10-04 | 2012-04-25 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drive mechanism for drug delivery device |
| DE602005017182D1 (en) | 2004-10-21 | 2009-11-26 | Novo Nordisk As | INJECTION DEVICE WITH TORSION SPRING AND ROTATABLE DISPLAY |
| ATE444090T1 (en) | 2004-10-21 | 2009-10-15 | Novo Nordisk As | SELECTION MECHANISM FOR A ROTARY PIN |
| EP1877121B1 (en) | 2005-04-24 | 2015-09-23 | Novo Nordisk A/S | Injection device |
| US20070113861A1 (en) * | 2005-11-08 | 2007-05-24 | Novo Nordisk A/S | Cap for a medical device |
| JP4834389B2 (en) * | 2005-11-29 | 2011-12-14 | 前田産業株式会社 | Injection device |
| GB0524604D0 (en) * | 2005-12-02 | 2006-01-11 | Owen Mumford Ltd | Injection method and apparatus |
| EP1965846A1 (en) * | 2005-12-08 | 2008-09-10 | Eli Lilly And Company | Dose indicating assembly of a pharmaceutical injection device |
| GB2434103B (en) * | 2006-01-12 | 2009-11-25 | Owen Mumford Ltd | Lancet firing device |
| JP5183499B2 (en) * | 2006-03-10 | 2013-04-17 | ノボ・ノルデイスク・エー／エス | Injection device |
| JP5062768B2 (en) * | 2006-03-10 | 2012-10-31 | ノボ・ノルデイスク・エー／エス | INJECTION DEVICE AND METHOD FOR REPLACING CARTRIDGE OF THE DEVICE |
| DE602007004972D1 (en) | 2006-05-16 | 2010-04-08 | Novo Nordisk As | GEARING MECHANISM FOR AN INJECTION DEVICE |
| AU2007253481B2 (en) | 2006-05-18 | 2013-01-17 | Novo Nordisk A/S | An injection device with mode locking means |
| US8632506B2 (en) | 2006-06-30 | 2014-01-21 | Novo Nordisk A/S | Medical delivery system comprising a coding mechanism |
| ATE487417T1 (en) * | 2006-07-14 | 2010-11-15 | Hoffmann La Roche | INJECTION DEVICE WITH A SECOND DEVICE FUNCTION FOR OBTAINING A BODY FLUID SAMPLE |
| WO2008009647A1 (en) * | 2006-07-15 | 2008-01-24 | Novo Nordisk A/S | A medical delivery system with flexible blocking element |
| ATE493161T1 (en) * | 2006-07-15 | 2011-01-15 | Novo Nordisk As | MEDICAL DELIVERY SYSTEM WITH ASYMMETRIC CODING DEVICES |
| ATE493162T1 (en) * | 2006-08-28 | 2011-01-15 | Novo Nordisk As | AXIAL LOCKABLE AND ROTATION OPEN MEDICATION ADMINISTRATION SYSTEM |
| US20080077430A1 (en) * | 2006-09-25 | 2008-03-27 | Singer Michael S | Systems and methods for improving medication adherence |
| US20100042054A1 (en) * | 2006-11-17 | 2010-02-18 | Novo Nordisk A/S | Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container |
| DE602007014411D1 (en) | 2006-11-21 | 2011-06-16 | Novo Nordisk As | MEDICAL DISPENSING SYSTEM WITH LOCKING RING WITH L-SHAPED NUTS |
| JP2010512817A (en) * | 2006-12-15 | 2010-04-30 | ノボ・ノルデイスク・エー／エス | Medical delivery system comprising a container and a dosing assembly having a radially moving fastening means |
| EP2091600B1 (en) * | 2006-12-21 | 2019-02-20 | Novo Nordisk A/S | A syringe device |
| EP2115722A4 (en) * | 2007-01-12 | 2011-12-07 | Healthhonors Corp | Behavior modification with intermittent reward |
| PL2109474T5 (en) | 2007-02-05 | 2019-07-31 | Novo Nordisk A/S | Injection button |
| JP5230722B2 (en) | 2007-03-23 | 2013-07-10 | ノボ・ノルデイスク・エー／エス | Injection device with lock nut |
| DE102007018696A1 (en) | 2007-04-18 | 2008-10-23 | Sanofi-Aventis Deutschland Gmbh | Injection device for dispensing a medicament |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8172813B2 (en) * | 2008-02-28 | 2012-05-08 | Becton, Dickinson And Company | Syringe with two piece plunger rod |
| US7976510B2 (en) | 2008-02-28 | 2011-07-12 | Becton, Dickinson And Company | Syringe with adjustable two piece plunger rod |
| JP2009240411A (en) | 2008-03-28 | 2009-10-22 | Terumo Corp | Drug container |
| EP2274029B1 (en) | 2008-05-02 | 2011-11-02 | Sanofi-Aventis Deutschland GmbH | Medication delivery device |
| ES2398034T3 (en) * | 2008-07-09 | 2013-03-13 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device and a method of assembling a medication delivery device |
| WO2010033882A2 (en) * | 2008-09-18 | 2010-03-25 | Becton, Dickinson And Company | Medical injector with slidable sleeve activation |
| USRE47614E1 (en) | 2008-10-13 | 2019-09-24 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device and method of manufacturing a drug delivery device |
| GB2465390A (en) | 2008-11-17 | 2010-05-19 | Owen Mumford Ltd | Syringe needle cover remover |
| EP2196233A1 (en) | 2008-12-12 | 2010-06-16 | Sanofi-Aventis Deutschland GmbH | Resettable drive mechanism for a medication delivery device and medication delivery device |
| EP2393542B1 (en) * | 2009-02-06 | 2016-09-28 | Becton Dickinson and Company | Lubricated pen needle |
| CA2756966A1 (en) | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Dose button for a drug delivery device and method for manufacturing a dose button |
| EP2415041B1 (en) | 2009-03-31 | 2018-11-21 | Sanofi-Aventis Deutschland GmbH | Method for manufacturing a drug delivery device body using an adhesive and drug delivery device body |
| WO2010112558A1 (en) * | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with dose indication window |
| JP5748738B2 (en) | 2009-03-31 | 2015-07-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drug delivery device |
| CN102448527B (en) | 2009-03-31 | 2015-10-21 | 赛诺菲-安万特德国有限公司 | The cap for brush |
| NZ595940A (en) | 2009-04-30 | 2013-07-26 | Sanofi Aventis Deutschland | Axially adjustable connection of piston rod to piston for drive mechanism of a drug delivery device with an interlock means to lock the piston rod to the piston |
| US8672896B2 (en) * | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
| US10034982B2 (en) | 2009-06-01 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Spindle for a drug delivery device |
| US8257319B2 (en) | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
| AR076722A1 (en) | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | SET FOR A DEVICE FOR THE DELIVERY OF PHARMACOS AND DEVICE FOR THE DELIVERY OF PHARMACOS |
| EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
| JP5866286B2 (en) * | 2009-09-30 | 2016-02-17 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Assembly of drug delivery device |
| CA2773928A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Injection device |
| GB0918145D0 (en) | 2009-10-16 | 2009-12-02 | Owen Mumford Ltd | Injector apparatus |
| PL215310B1 (en) | 2009-10-30 | 2013-11-29 | Kappa Medilab Spolka Z Ograniczona Odpowiedzialnoscia | Automatic applicator, especially for insulin |
| AU2010314169B2 (en) | 2009-11-03 | 2014-09-04 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
| WO2011067267A1 (en) * | 2009-12-02 | 2011-06-09 | Sanofi-Aventis Deutschland Gmbh | Dose display mechanism for a drug delivery device |
| GB201004626D0 (en) | 2010-03-19 | 2010-05-05 | Owen Mumford Ltd | Improved injection device |
| CA2743198C (en) | 2010-06-18 | 2019-06-11 | Lawrence H. Chanoch | Adjustable dose setting plunger for syringe |
| EP2600922B2 (en) | 2010-08-06 | 2022-07-20 | Sanofi-Aventis Deutschland GmbH | Cartridge holder and method for assembling a cartridge unit for a drug delivery device |
| CN103180000B (en) * | 2010-10-25 | 2015-09-09 | 赛诺菲-安万特德国有限公司 | Drug delivery device and the method for assembling drug delivery device |
| AR086257A1 (en) | 2011-05-06 | 2013-11-27 | Sanofi Aventis Deutschland | FARMACOS ADMINISTRATION DEVICE AND CARTRIDGE SUPPORT FOR A FARMACOS ADMINISTRATION DEVICE |
| JP6069351B2 (en) | 2011-12-29 | 2017-02-01 | ノボ・ノルデイスク・エー／エス | Torsion spring type automatic syringe with dial-up / dial-down administration mechanism |
| AU2013245106B2 (en) * | 2012-04-05 | 2017-07-27 | Sanofi-Aventis Deutschland Gmbh | Pen -type injector with window element |
| CN104203316A (en) | 2012-04-19 | 2014-12-10 | 赛诺菲-安万特德国有限公司 | Assembly for a drug delivery device and drug delivery device |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| WO2013178600A1 (en) | 2012-05-30 | 2013-12-05 | Sanofi-Aventis Deutschland Gmbh | Bearing for a piston rod body for a drug delivery device, a piston rod arrangement and a piston rod body |
| US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| CN104507518B (en) * | 2012-07-06 | 2017-08-11 | 卡贝欧洲有限公司 | Delivery device |
| US20150165122A1 (en) | 2012-08-08 | 2015-06-18 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with tamper-evident closure |
| ES2941078T3 (en) | 2012-08-31 | 2023-05-16 | Sanofi Aventis Deutschland | drug delivery device |
| KR102166894B1 (en) | 2012-08-31 | 2020-10-16 | 사노피-아벤티스 도이칠란트 게엠베하 | Drug delivery device |
| WO2014040929A1 (en) | 2012-09-11 | 2014-03-20 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and drug delivery device |
| BR112015010607A2 (en) | 2012-11-09 | 2017-12-05 | Iinjec Tech Inc | fluid delivery injector, retractable needle assembly, and method for injecting at least one dose of a transcutaneously fluid medication into the body. |
| TWI653069B (en) | 2013-03-11 | 2019-03-11 | 德商賽諾菲阿凡提斯德意志有限公司 | "piston rod and drug delivery device comprising the piston rod" |
| EP2968783B1 (en) | 2013-03-13 | 2021-04-21 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device comprising a feedback feature |
| DK2968786T3 (en) | 2013-03-13 | 2020-12-14 | Sanofi Aventis Deutschland | MEDICINE DELIVERY DEVICE WITH A FEEDBACK FUNCTION |
| WO2014139915A1 (en) * | 2013-03-13 | 2014-09-18 | Sanofi-Aventis Deutschland Gmbh | Drug injection device with particular optical window elements for unambiguous legibility of dose value |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| US9180243B2 (en) | 2013-03-15 | 2015-11-10 | Tandem Diabetes Care, Inc. | Detection of infusion pump conditions |
| WO2014154777A1 (en) * | 2013-03-28 | 2014-10-02 | Sanofi-Aventis Deutschland Gmbh | Filling device for a drug delivery device and system with a fillings device and drug delivery device |
| EP2983761B1 (en) | 2013-04-10 | 2017-11-15 | Sanofi | Drive assembly for a drug delivery device |
| KR102296049B1 (en) | 2013-05-16 | 2021-08-30 | 사노피-아벤티스 도이칠란트 게엠베하 | Mechanism for a drug delivery device |
| WO2014191190A1 (en) | 2013-05-27 | 2014-12-04 | Sanofi-Aventis Deutschland Gmbh | Drive assembly for a drug delivery device and drug delivery device |
| AU2014314290B2 (en) | 2013-08-29 | 2018-11-08 | Sanofi-Aventis Deutschland Gmbh | Housing and cap for an injection device made of an outer metal part and an inner plastic part |
| HUE047773T2 (en) | 2013-08-29 | 2020-05-28 | Sanofi Aventis Deutschland | Cap for a drug delivery device |
| HUE055023T2 (en) | 2013-08-29 | 2021-10-28 | Sanofi Aventis Deutschland | Cap assembly for a drug delivery device and drug delivery device |
| EP3041538B1 (en) | 2013-09-03 | 2020-06-03 | Sanofi | Drive mechanism and injection device herewith |
| PL3049131T3 (en) | 2013-09-23 | 2021-04-19 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
| KR200475972Y1 (en) * | 2013-10-02 | 2015-01-21 | (주)아모레퍼시픽 | A Cosmetic Liquid Syringe |
| US10159801B2 (en) | 2013-12-20 | 2018-12-25 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
| USD770038S1 (en) | 2014-06-26 | 2016-10-25 | Eli Lilly And Company | Medication injection device |
| CA3009221A1 (en) | 2014-12-23 | 2016-06-30 | Automed Pty Ltd | Delivery apparatus, system and associated methods |
| EP3064239A1 (en) * | 2015-03-05 | 2016-09-07 | Carebay Europe Ltd. | Medicament delivery device with information provider system |
| TWI711472B (en) | 2015-03-23 | 2020-12-01 | 德商賽諾菲阿凡提斯德意志有限公司 | Housing for an injection device and interconnection of housing components |
| PL414382A1 (en) | 2015-10-15 | 2017-04-24 | Copernicus Spółka Z Ograniczoną Odpowiedzialnością | Setting mechanism, in particular for dosing |
| WO2017114612A1 (en) * | 2015-12-30 | 2017-07-06 | Carebay Europe Ltd | Medicament delivery device |
| JP6969876B2 (en) | 2016-02-29 | 2021-11-24 | メディセル・アーゲー | Transmission mechanism, especially injectors with gear trains |
| EP3348294A1 (en) | 2017-01-13 | 2018-07-18 | Carebay Europe Ltd. | Medicament delivery device |
| CN111050750A (en) | 2017-08-24 | 2020-04-21 | 诺沃挪第克公司 | GLP-1 compositions and uses thereof |
| EP4106727A1 (en) | 2020-02-18 | 2022-12-28 | Novo Nordisk A/S | Pharmaceutical formulations |
| US11957542B2 (en) | 2020-04-30 | 2024-04-16 | Automed Patent Holdco, Llc | Sensing complete injection for animal injection device |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3232117A (en) * | 1962-09-14 | 1966-02-01 | Roger Gilmont Instr Inc | Micrometer buret |
| DE1632032B2 (en) * | 1967-12-20 | 1977-11-03 | Fa Rudolf Brand, 6980 Wertheim | INSTRUMENT FOR PROMOTING AND VARIABLE PRE-SELECTABLE DOSING OF LIQUIDS |
| US3613952A (en) * | 1970-04-23 | 1971-10-19 | Cole Parmer Instr Co | Fluid dispenser with adjustable stroke piston and register |
| US3815785A (en) * | 1972-12-04 | 1974-06-11 | Gilmont R Instr Inc | Micrometric dispenser with calibration means |
| US4096751A (en) * | 1977-06-15 | 1978-06-27 | Oxford Laboratories Inc. | Hand-held micropipettor with fluid transfer volume adjustment mechanism |
| EP0037696B1 (en) * | 1980-04-08 | 1984-05-23 | Greater Glasgow Health Board | Dispensing device |
| DE3031830C2 (en) * | 1980-08-23 | 1983-02-17 | Witeg-Glasgeräte Helmut Antlinger KG, 6980 Wertheim | Bottle dispenser |
| IE52621B1 (en) * | 1981-02-12 | 1988-01-06 | Turner Robert Charles | Dose metering plunger devices for use with syringes |
| US4367739A (en) * | 1981-04-20 | 1983-01-11 | Leveen Harry H | Syringe |
| US4395921A (en) * | 1981-06-26 | 1983-08-02 | Scientific Manufacturing Industries, Inc. | Adjustable volume liquid dispenser |
| US4475905A (en) * | 1982-09-30 | 1984-10-09 | Himmelstrup Anders B | Injection device |
| US4592745A (en) * | 1984-02-29 | 1986-06-03 | Novo Industri A/S | Dispenser |
| DE3670768D1 (en) * | 1985-11-08 | 1990-06-07 | Disetronic Ag | INJECTION DEVICE. |
| DE3638984C3 (en) * | 1986-11-14 | 1993-11-18 | Haselmeier Wilhelm Fa | Injection device |
| DK177187A (en) * | 1987-04-07 | 1988-10-08 | Dcp Af 1988 As | DOSING UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A FLUID, SUCH AS INSULIN, FROM A GLASS AMPULA |
| DE3715258C2 (en) * | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injection device |
| GB8713810D0 (en) * | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
| CH675078A5 (en) * | 1988-01-22 | 1990-08-31 | Nosta Ag | |
| DK166948B1 (en) * | 1988-02-10 | 1993-08-09 | Dcp Af 1988 As | DOSING UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A FLUID, SUCH AS INSULIN, FROM A GLASS STUBLE |
| US4973318A (en) * | 1988-02-10 | 1990-11-27 | D.C.P. Af 1988 A/S | Disposable syringe |
| GB8809115D0 (en) * | 1988-04-18 | 1988-05-18 | Turner R C | Syringes |
| US5244465A (en) * | 1988-10-19 | 1993-09-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Reusable injection device for distributing a preselected dose |
-
1990
- 1990-04-04 US US07/504,254 patent/US5226896A/en not_active Expired - Lifetime
-
1991
- 1991-03-20 NO NO911115A patent/NO300306B1/en not_active IP Right Cessation
- 1991-03-26 IL IL9768391A patent/IL97683A/en not_active IP Right Cessation
- 1991-03-28 ZA ZA912399A patent/ZA912399B/en unknown
- 1991-03-28 CA CA002039471A patent/CA2039471C/en not_active Expired - Fee Related
- 1991-03-28 NZ NZ237622A patent/NZ237622A/en unknown
- 1991-04-01 AR AR91319361A patent/AR245371A1/en active
- 1991-04-01 MX MX025155A patent/MX173301B/en unknown
- 1991-04-02 FI FI911583A patent/FI104235B1/en active
- 1991-04-02 DK DK91302864.3T patent/DK0450905T3/en active
- 1991-04-02 AU AU74026/91A patent/AU639542B2/en not_active Ceased
- 1991-04-02 ES ES91302864T patent/ES2079565T3/en not_active Expired - Lifetime
- 1991-04-02 DE DE69113847T patent/DE69113847T2/en not_active Expired - Fee Related
- 1991-04-02 EP EP91302864A patent/EP0450905B1/en not_active Expired - Lifetime
- 1991-04-02 AT AT91302864T patent/ATE129162T1/en not_active IP Right Cessation
- 1991-04-03 IE IE110091A patent/IE69664B1/en not_active IP Right Cessation
- 1991-04-03 PT PT97248A patent/PT97248B/en active IP Right Grant
- 1991-04-03 RU SU914895034A patent/RU2033193C1/en active
- 1991-04-03 HU HU911083A patent/HU210293B/en not_active IP Right Cessation
- 1991-04-03 KR KR1019910005330A patent/KR960000846B1/en not_active IP Right Cessation
- 1991-04-03 JP JP3070830A patent/JPH066159B2/en not_active Expired - Fee Related
- 1991-04-03 YU YU59291A patent/YU47961B/en unknown
-
1993
- 1993-06-25 US US08/083,740 patent/US5295976A/en not_active Expired - Lifetime
-
1995
- 1995-11-08 GR GR950403108T patent/GR3017999T3/en unknown
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