CA2054189A1 - Stable ascorbic acid compositions - Google Patents

Stable ascorbic acid compositions

Info

Publication number
CA2054189A1
CA2054189A1 CA2054189A CA2054189A CA2054189A1 CA 2054189 A1 CA2054189 A1 CA 2054189A1 CA 2054189 A CA2054189 A CA 2054189A CA 2054189 A CA2054189 A CA 2054189A CA 2054189 A1 CA2054189 A1 CA 2054189A1
Authority
CA
Canada
Prior art keywords
ascorbic acid
water
composition
carrier
acid compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2054189A
Other languages
French (fr)
Other versions
CA2054189C (en
Inventor
Douglas Darr
Sheldon R. Pinnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Douglas Darr
Sheldon R. Pinnell
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23329228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2054189(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Douglas Darr, Sheldon R. Pinnell, Duke University filed Critical Douglas Darr
Publication of CA2054189A1 publication Critical patent/CA2054189A1/en
Application granted granted Critical
Publication of CA2054189C publication Critical patent/CA2054189C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Abstract

A stable topical composition consists essentially of at least about 1 wt.% L-ascobic acid, preferably from about 3 to 20 wt.
% L-ascorbic acid, and more preferably about 5 to 10 wt% L-ascorbic acid in water and a carrier for topical application is disclosed. Such a composition appears to allow ready penetration into the skin and retards the damage caused by ultraviolet tight.
Any composition containing at least about 1 wt. % L-ascorbic acid is expected to have beneficial effects, with the concentration of L-ascorbic acid being primarily limited by its solubility in the water/carrier system. The ratio of water to carrier is at least 1:1, and more preferably from 2:1 to 10:1, and the pH of the composition is no more than 3.0 to 3:5, preferably no more than about 2.5.
CA002054189A 1989-04-17 1990-04-16 Stable ascorbic acid compositions Expired - Lifetime CA2054189C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US339,488 1989-04-17
US07/339,488 US5140043A (en) 1989-04-17 1989-04-17 Stable ascorbic acid compositions
PCT/US1990/001968 WO1990012572A1 (en) 1989-04-17 1990-04-16 Stable ascorbic acid compositions

Publications (2)

Publication Number Publication Date
CA2054189A1 true CA2054189A1 (en) 1990-10-18
CA2054189C CA2054189C (en) 2000-11-21

Family

ID=23329228

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002054189A Expired - Lifetime CA2054189C (en) 1989-04-17 1990-04-16 Stable ascorbic acid compositions

Country Status (11)

Country Link
US (1) US5140043A (en)
EP (1) EP0486499B1 (en)
JP (1) JP3708540B2 (en)
AT (1) ATE156355T1 (en)
AU (1) AU647699B2 (en)
CA (1) CA2054189C (en)
DE (1) DE69031219T2 (en)
DK (1) DK0486499T3 (en)
ES (1) ES2104605T3 (en)
HK (1) HK1001834A1 (en)
WO (1) WO1990012572A1 (en)

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EP0486499A4 (en) 1993-06-16
ATE156355T1 (en) 1997-08-15
HK1001834A1 (en) 1998-07-10
US5140043A (en) 1992-08-18
JPH04507089A (en) 1992-12-10
ES2104605T3 (en) 1997-10-16
WO1990012572A1 (en) 1990-11-01
JP3708540B2 (en) 2005-10-19
CA2054189C (en) 2000-11-21
DK0486499T3 (en) 1998-03-16
AU647699B2 (en) 1994-03-24
DE69031219T2 (en) 1998-01-22
AU5523990A (en) 1990-11-16
EP0486499B1 (en) 1997-08-06
DE69031219D1 (en) 1997-09-11
EP0486499A1 (en) 1992-05-27

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