CA2054268C - Nutritional composition - Google Patents
Nutritional composition Download PDFInfo
- Publication number
- CA2054268C CA2054268C CA002054268A CA2054268A CA2054268C CA 2054268 C CA2054268 C CA 2054268C CA 002054268 A CA002054268 A CA 002054268A CA 2054268 A CA2054268 A CA 2054268A CA 2054268 C CA2054268 C CA 2054268C
- Authority
- CA
- Canada
- Prior art keywords
- mcg
- composition
- protein
- per
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 126
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 63
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 53
- 229940088594 vitamin Drugs 0.000 claims abstract description 25
- 229930003231 vitamin Natural products 0.000 claims abstract description 25
- 235000013343 vitamin Nutrition 0.000 claims abstract description 25
- 239000011782 vitamin Substances 0.000 claims abstract description 25
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 20
- 239000011707 mineral Substances 0.000 claims abstract description 20
- 235000020776 essential amino acid Nutrition 0.000 claims abstract description 12
- 239000003797 essential amino acid Substances 0.000 claims abstract description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 206
- 229910052757 nitrogen Inorganic materials 0.000 claims description 105
- 235000005911 diet Nutrition 0.000 claims description 72
- 230000037213 diet Effects 0.000 claims description 62
- 150000001413 amino acids Chemical class 0.000 claims description 50
- 229940024606 amino acid Drugs 0.000 claims description 49
- 230000014075 nitrogen utilization Effects 0.000 claims description 41
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 31
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 31
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 31
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 30
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 30
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 30
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 30
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 30
- 239000004472 Lysine Substances 0.000 claims description 29
- 229960000310 isoleucine Drugs 0.000 claims description 29
- 229930182817 methionine Natural products 0.000 claims description 29
- 230000035764 nutrition Effects 0.000 claims description 29
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 29
- 239000004473 Threonine Substances 0.000 claims description 28
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 28
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 28
- 239000004474 valine Substances 0.000 claims description 28
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 27
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 27
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 27
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 26
- 235000019871 vegetable fat Nutrition 0.000 claims description 24
- 208000030507 AIDS Diseases 0.000 claims description 18
- 235000019485 Safflower oil Nutrition 0.000 claims description 15
- 229930006000 Sucrose Natural products 0.000 claims description 15
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 15
- 235000019486 Sunflower oil Nutrition 0.000 claims description 15
- 239000003813 safflower oil Substances 0.000 claims description 15
- 235000005713 safflower oil Nutrition 0.000 claims description 15
- 239000005720 sucrose Substances 0.000 claims description 15
- 239000002600 sunflower oil Substances 0.000 claims description 15
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 14
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 14
- 239000002285 corn oil Substances 0.000 claims description 14
- 235000005687 corn oil Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 11
- 239000000600 sorbitol Substances 0.000 claims description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 208000011580 syndromic disease Diseases 0.000 claims description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
- 229930003779 Vitamin B12 Natural products 0.000 claims description 4
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 235000019163 vitamin B12 Nutrition 0.000 claims description 4
- 239000011715 vitamin B12 Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- 229930003451 Vitamin B1 Natural products 0.000 claims description 3
- 229930003316 Vitamin D Natural products 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- 229930003448 Vitamin K Natural products 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
- 229960002685 biotin Drugs 0.000 claims description 3
- 235000020958 biotin Nutrition 0.000 claims description 3
- 239000011616 biotin Substances 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 3
- 235000010374 vitamin B1 Nutrition 0.000 claims description 3
- 239000011691 vitamin B1 Substances 0.000 claims description 3
- 235000019158 vitamin B6 Nutrition 0.000 claims description 3
- 239000011726 vitamin B6 Substances 0.000 claims description 3
- 235000019166 vitamin D Nutrition 0.000 claims description 3
- 239000011710 vitamin D Substances 0.000 claims description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 3
- 235000019168 vitamin K Nutrition 0.000 claims description 3
- 239000011712 vitamin K Substances 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- 229940011671 vitamin b6 Drugs 0.000 claims description 3
- 229940046008 vitamin d Drugs 0.000 claims description 3
- 229940046010 vitamin k Drugs 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229930003471 Vitamin B2 Natural products 0.000 claims description 2
- 229940087168 alpha tocopherol Drugs 0.000 claims description 2
- 229910052796 boron Inorganic materials 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052804 chromium Inorganic materials 0.000 claims description 2
- 239000011651 chromium Substances 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229960000304 folic acid Drugs 0.000 claims description 2
- 235000019152 folic acid Nutrition 0.000 claims description 2
- 239000011724 folic acid Substances 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 229910052748 manganese Inorganic materials 0.000 claims description 2
- 239000011572 manganese Substances 0.000 claims description 2
- 229910052750 molybdenum Inorganic materials 0.000 claims description 2
- 239000011733 molybdenum Substances 0.000 claims description 2
- 229910052759 nickel Inorganic materials 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 229940055726 pantothenic acid Drugs 0.000 claims description 2
- 235000019161 pantothenic acid Nutrition 0.000 claims description 2
- 239000011713 pantothenic acid Substances 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229960000984 tocofersolan Drugs 0.000 claims description 2
- 235000019164 vitamin B2 Nutrition 0.000 claims description 2
- 239000011716 vitamin B2 Substances 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 235000004835 α-tocopherol Nutrition 0.000 claims description 2
- 239000002076 α-tocopherol Substances 0.000 claims description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 abstract description 51
- 235000010755 mineral Nutrition 0.000 abstract description 18
- 235000018102 proteins Nutrition 0.000 description 53
- 102000004169 proteins and genes Human genes 0.000 description 53
- 108090000623 proteins and genes Proteins 0.000 description 53
- 235000001014 amino acid Nutrition 0.000 description 46
- 235000013350 formula milk Nutrition 0.000 description 32
- 208000002720 Malnutrition Diseases 0.000 description 26
- 239000003925 fat Substances 0.000 description 26
- 235000019197 fats Nutrition 0.000 description 26
- 229960004452 methionine Drugs 0.000 description 24
- 208000003286 Protein-Energy Malnutrition Diseases 0.000 description 23
- 229960005190 phenylalanine Drugs 0.000 description 23
- 229960004799 tryptophan Drugs 0.000 description 23
- 229960004295 valine Drugs 0.000 description 23
- 229960003136 leucine Drugs 0.000 description 22
- 235000018977 lysine Nutrition 0.000 description 22
- 229960002898 threonine Drugs 0.000 description 22
- 235000005772 leucine Nutrition 0.000 description 21
- 210000001519 tissue Anatomy 0.000 description 18
- 235000004626 essential fatty acids Nutrition 0.000 description 15
- 235000013305 food Nutrition 0.000 description 13
- 206010001513 AIDS related complex Diseases 0.000 description 12
- 235000019621 digestibility Nutrition 0.000 description 12
- 235000021075 protein intake Nutrition 0.000 description 12
- 235000020616 amino acid formula Nutrition 0.000 description 11
- 235000019577 caloric intake Nutrition 0.000 description 11
- 230000002265 prevention Effects 0.000 description 11
- 230000000378 dietary effect Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 230000000295 complement effect Effects 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 239000013589 supplement Substances 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 108010010234 HDL Lipoproteins Proteins 0.000 description 6
- 102000015779 HDL Lipoproteins Human genes 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 208000019423 liver disease Diseases 0.000 description 6
- 235000000824 malnutrition Nutrition 0.000 description 6
- 230000001071 malnutrition Effects 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 208000015380 nutritional deficiency disease Diseases 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 201000005569 Gout Diseases 0.000 description 5
- 108010007622 LDL Lipoproteins Proteins 0.000 description 5
- 102000007330 LDL Lipoproteins Human genes 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 235000021085 polyunsaturated fats Nutrition 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 208000017169 kidney disease Diseases 0.000 description 4
- 201000006370 kidney failure Diseases 0.000 description 4
- 150000004671 saturated fatty acids Chemical class 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 235000013311 vegetables Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000007848 Alcoholism Diseases 0.000 description 3
- 208000017667 Chronic Disease Diseases 0.000 description 3
- 201000003883 Cystic fibrosis Diseases 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 208000004262 Food Hypersensitivity Diseases 0.000 description 3
- 206010016946 Food allergy Diseases 0.000 description 3
- 208000035150 Hypercholesterolemia Diseases 0.000 description 3
- 206010061598 Immunodeficiency Diseases 0.000 description 3
- 208000029462 Immunodeficiency disease Diseases 0.000 description 3
- 201000002772 Kwashiorkor Diseases 0.000 description 3
- 206010025476 Malabsorption Diseases 0.000 description 3
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 3
- 208000012902 Nervous system disease Diseases 0.000 description 3
- 208000001647 Renal Insufficiency Diseases 0.000 description 3
- 108010069201 VLDL Cholesterol Proteins 0.000 description 3
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 201000007930 alcohol dependence Diseases 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000003090 exacerbative effect Effects 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- 235000020932 food allergy Nutrition 0.000 description 3
- 239000002117 illicit drug Substances 0.000 description 3
- 230000007813 immunodeficiency Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 206010026820 marasmus Diseases 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 235000003441 saturated fatty acids Nutrition 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- 244000099147 Ananas comosus Species 0.000 description 2
- 235000007119 Ananas comosus Nutrition 0.000 description 2
- 244000028477 Annona glabra Species 0.000 description 2
- 235000005290 Annona glabra Nutrition 0.000 description 2
- 208000000103 Anorexia Nervosa Diseases 0.000 description 2
- 240000006432 Carica papaya Species 0.000 description 2
- 235000009467 Carica papaya Nutrition 0.000 description 2
- 244000241235 Citrullus lanatus Species 0.000 description 2
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000025966 Neurological disease Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 244000191761 Sida cordifolia Species 0.000 description 2
- 108010062497 VLDL Lipoproteins Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 229960003646 lysine Drugs 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 229940029985 mineral supplement Drugs 0.000 description 2
- 208000030212 nutrition disease Diseases 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 230000022558 protein metabolic process Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- -1 sucrose Chemical class 0.000 description 2
- 230000003319 supportive effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- WRRSFOZOETZUPG-FFHNEAJVSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrate Chemical compound O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC WRRSFOZOETZUPG-FFHNEAJVSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 244000036905 Benincasa cerifera Species 0.000 description 1
- 235000011274 Benincasa cerifera Nutrition 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 101100067721 Caenorhabditis elegans gly-3 gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- OABOXRPGTFRBFZ-IMJSIDKUSA-N Cys-Cys Chemical compound SC[C@H](N)C(=O)N[C@@H](CS)C(O)=O OABOXRPGTFRBFZ-IMJSIDKUSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 244000061508 Eriobotrya japonica Species 0.000 description 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 244000307700 Fragaria vesca Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 208000003623 Hypoalbuminemia Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 229930182844 L-isoleucine Natural products 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 244000149260 Manihot esculenta subsp flabellifolia Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000007660 Sechium edule Species 0.000 description 1
- 235000019095 Sechium edule Nutrition 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 206010049416 Short-bowel syndrome Diseases 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000003851 biochemical process Effects 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 108010004073 cysteinylcysteine Proteins 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940082652 electrolytes and nutrients iv solution used in parenteral administration of fluids Drugs 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 208000020694 gallbladder disease Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 208000027700 hepatic dysfunction Diseases 0.000 description 1
- 229960002885 histidine Drugs 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 235000021048 nutrient requirements Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000007065 protein hydrolysis Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
A novel nutritional composition is disclosed which is based on essential amino acids and optionally vitamins, minerals and carbohydrates.
Description
a NUTRTTIOR~1AL COMPOS ITIOP1 BACizGROUP1D OF THE INVEF1TION
Human nutrition requires a source of the components of protein, carbohydrates, lipids, vitamins and minerals.
Many and varied sources for these nutrient materials have been utilized in the prior art. The prior art does not disclose the concept of providing a balanced supply of nutrients which permits substantially complete absorption of the nutrients which are administered to an individual.
Proteins are associated with all forms of life, an observation that dates back to the original identification of protein as a class by Mulder in 1838. The proteins of living matter act as organic catalysts (enzymes), as structural features of the cell, as messengers (peptide hormones), and as antibodies. The importance of protein in the diet is primarily to act as a source of amino acids, some of which are essential (indispensable) dietary constituents because their carbon skeletons axe not synthesized in the bodies of animals, It is known that the adult human requires eight amino acids which are essential .for the maintenance of good health. These amino acids are isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine.
Amino acid solutions are commercially available for ~ nutrient I.V. feeding of post operative patients, pediatric patients, patients with renal failure and patients with hepatic failure. The available amino acid I.V. solutions are based on crystalline amino acids which have an advantage over the amino acids solutions which were obtained by hydrolysis of proteins such as fibrin or casein. These solutions were nutritionally incomplete in the amino acid content and caused toxic reactions which led to the banning of these solutions in the United States by the Food and Drug Administration.
Amino acid solutions are available which contain ~ all of the essential amino acids in combination with ~~~~~s 8 .. 2 _ non-essential amino acids, with or without vitamins, minerals and a carbohydrate and fat source.
To estimate the nutritional value of protein as well as amino acid formulas, the accepted methodology is to determine, during the ingestion of a proteins) or an amino acid formula, the subject's nitrogen balance. This represents the difference between nitrogen intake and nitrogen output, the difference being either positive (nitrogen retention, as in active growth), negative (nitrogen loss), or zero (nitrogen equilibrium).
In order to carefully determine nitrogen balance (nitrogen intake - nitrogen output), I have used the formula:*
= T - (U + F + S)*
where:
B = Nitrogen Balance I - Nitrogen Intake U = Nitrogen Loss In Urine F = Nitrogen Loss In Feces S = Nitrogen Dermal Losses This formula has been used to compute the Net Nitrogen Utilization (NNU) for the amino acid formulas and proteins that were tested.
The prior art amino acid solutions, which have widely different ratios of the component amino acids, have not been found to be suitable as total nutrient compositions because after prolonged reliance on these compositions, symptoms of nutrient deficiency are detected due to the low percentage of their net nitrogen utilization (NNU). The low ~ net nitrogen utilization (NNU) results in the presence of unabsorbed amino acids, which are deaminated and cause an increased production of blood urea nitrogen (BUN) as well as * Munro, H.N., Crim M.C., in "Modern Nutrition In Health and Disease" Shils, M.R., Young, V.R. (Eds), page 24, Lea &
g5 Febiger, Philadelphia 1988 2~~~~~~~
increased levels of other metabolic nitrogen containing products. This problem is particularly difficult with patients who have renal failure and/or hepatic disorders.
United States Letters Patent No. 3,697,287 disclose an amino acid food composition which is described as a palatable mixture of the essential and non-essential amino acids, minerals, vitamins, carbohydrates and fats. That composition contains essential and non-essential amino acids.
The essential amino acids in such a composition are present in the following ratios:
L-valine 1.0 L-arginine 1,77 L-isoleucine ,g1 L-lysine 1.03 L-phenylalan.ine 1.03 L-histidine .44 L-leucine 1,43 L-methionine ,g3 L-threonine ,g1 L-tryptophan .28 I have discovered that the use of an amino acid composition which contains specific proportions of the essential amino acids will make possible a higher NNU as compared to high NNU protein such as hen whole egg protein or other amino acid compositions. I have discovered that the oral administration of a composition which consists of essential amino acids will result in a higher NNU as compared to compositions which also include non-essential amino acids.
In addition, the use of a preferred embodiment of the invention, will avoid causing or unduly exacerbating the BUN
of patients in which the nitrogen intake is required to be restricted who are fed with certain of the applicant°s composition. The avoidance of exogenous residual nitrogen is achieved by the formulation of the amino acid composition with a specific ratio of the essential amino acids which provide for substantially complete absorption of the required quantity of the amino acids. The novel amino acid composition of the invention may be utilized alone or in combination with carbohydrates, lipids, vitamins and minerals depending on the particular nutrient requirements of a particular patient.
I have also discovered that the feeding of the amino acid composition of the invention has a profound immunostimulant effect which can be determined by the means of objective clinical criteria.
1~ The main function of dietary carbohydrate is to provide energy. Administration of carbohydrate has long been known to spare protein in early fasting.
Protein is abruptly lost upon initiating a fast or upon withdrawing carbohydrates from an adequate diet (even if replaced isoenergetically by fat). Glucose is the main carbohydrate in the body arid although glucose can be utilized by all cells, it is essential only in a few organs, including the brain and the red cells. Although glucose can be converted to fat, it should be noted that fat cannot be converted to glucose. All the dietary carbohydrates seem to reduce the level of high-density lipoprotein (HDL) cholesterol in the serum, and HDL cholesterol.:total cholesterol ratio in the serum is reduced to a greater extent by sucrose than by glucose. The type of dietary carbohydrate can alter the 2S level of triglyceridemia, and this effect can be negated by the addition of polyunsaturated fat to the diet.
Dietary lipids consist mainly of triglycerides (TG), a useful and concentrated source of energy. An adequate TG supply and absorption are especially important for infants and also for adults with a high energy requirement, such as patients with major burns, malignant tumors, and surgical wounds. The alternative energy sources, protein and carbohydrates, deliver per gram, 4 FCcal, less than half the energy density of fats, and require bulky meals to cover high energy requirements. Essential Fatty Acids (EFA) are ~~~~:~v~3 necessary for the normal function of all tissues, it is therefore not surprising that the list of symptoms of EFA
deficiency is a long one. As no animal, including man, can synthesize EFA, it is completely dependent on vegetable lipids to meet EFA requirements.
It has been demonstrated convincingly that diets enriched in EFA such as linoleic acid and reduced in saturated fatty acids do lower significantly LDL and VLDL
cholesterol in man at both 30 and 40 in ~ of fat levels (3).
I have discovered that the oral administration of a composition which contains specific proportion of protein-free carbohydrate and protein-free polyunsaturated vegetable fat results in a palatable mixture having the highest apparent digestibility (AD) a higher Energy Density per weight and per volume and a higher content in EFA joined with a lower content in saturated tatty acids of any natural food or palatable dietetic composition for use as a complement in feeding patients such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism, and/or fail to eat, because of a physiological and/or psychological lack of appetite.
Each dietary fuel differs in apparent digestibility (~), which is calculated as:
(Intake-Stool losses) x 100 Intake To illustrate: If 100 grams of fat are ingested per day, and if the daily stool fat averages 5 grams, then the "apparent digestibility" (AD) of fat is 95~.
I have discovered that the oral administration of a composition which contains specific proportion of mineral-free, protein-free carbohydrates) and highly polyunsaturated vegetable fats) with the highest content in EFA join with the lowest content in saturated fatty acids, results in a palatable mixture which will avoid causing or unduly ,.. Y.7 4,a~ ~,~
_ 6 O
exacerbating the level of High-Density Lipoprotein (HDL), Low-density-Lipoprotein (LDL) and Very Low-Density-Lipoprotein (VLDL) cholesterol in the serum of patients in which HDL, LDL
and VLDL cholesterol level is required to be restricted who are fed with certain of the appl.icant's composition.
I have also discovered that the oral administration of a composition which contains specific proportion of mineral free, protein-free carbohydrate and highly polyunsaturated vegetable fat results in a palatable mixture which will avoid causing or unduly exacerbating the Blood Urea Nitrogen (BUN) of patients in which nitrogen intake is required to be restricted who are fed with certain of the applicant's compositions.
I have also discovered a novel concept for providing vitamin and mineral requirements by means of a method which is based on the administration o.f an amount of vitamins and minerals which is proportionate to the amount of amino acid which are administered.
I also discovered an object of the invention to provide an improved palatable mineral Free protein-free carbohydrate and highly polyunsaturated vegetable fat based nutrient composition.
It is also an abject of the invention to provide a palatable protein-free carbohydrate and protein-free polyunsaturated fat based composition which is useful because of its highest apparent digestibility (AD) and energy density (ED) in the nutritional support of patients suffering from disease where restricted nitrogen intake is indicated such as in certain renal and hepatic dysfunctions.
~0 It is also an object of the invention to provide a palatable mineral-free protein-free carbohydrate and protein-free highly polyunsaturated vegetable fat based composition a higher apparent digestibility (AD) and energy density (ED) content and a higher EFA content joined with a lower saturated fatty acid content of any natural food -or palatable dietetic composition for use as a supplement in feeding patients such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism, and/or who fail to eat, because of a physiological and/or psychological lack of appetite.
It is also an object of the invention to provide a mineral-free, protein-free carbohydrate and highly polyunsaturated vegetable fat based composition which has the advantage of low storage and shipping cost which may be used as an emergency food to be shipped by air in response to catastrophic events.
SUMMARY OF THE INVENTION
In a broad aspect, the present invention relates to a nutritional composition comprising a combination of the following:
(a) isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine in amounts relative to one another which will provide a Net Nitrogen Utilization (NNU) of at least 80%;
(b) a carbohydrate selected from the group consisting of sucrose, maltose and sorbitol, and a highly polyunsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil; and (c) for each gram of amino acid, an amount of vitamins which is equivalent to the following:
Vitamin A 60.02 - 109.0 mcg Vitamin D 37.0 - 63.0 mcg Alpha-tocopherol 0.78 - 1.30 mg Vitamin K 2.0 - 4.0 mcg Vitamin B1 10.0 - 20.0 mcg Vitamin Bz 27.0 - 48.0 mcg - 7a -Nicotinamide 0.13 - 0.23mg Pantothenic Acid 0.18 - 0.30mcg Vitamin B6 13.0 - 23.0mcg Biotin 0.43 - 0.73mcg Folic Acid 3.5 - 6.5 mcg Vitamin B12 35.0 - 65.0ng Vitamin C 3.5 - 6.5 mg The invention comprises a novel amino acid composition comprising a combination of the following essential amino acids:
isoleucine;
leucine;
lysine;
methionine;
phenylalanine;
threonine;
tryptophan; and valine in amounts relative to one another which will provide a net nitrogen utilization (NNU) of at least 75%, preferably 80% or 90% and most preferably 950. The composition may also contain carbohydrates, Essential Fatty Acid (EFA) sources, vitamins and/or minerals.
The amino acid composition has particular use in providing essential nutrients for the prevention or treatment of Protein-Calorie Malnutrition (PCM), in feeding patients _8_ such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism and/or who .fail to eat, because of a physiological and/or psychological lack of appetite.
In particular, the amino acid composition may also be used for supportive nutrition in the case of trauma due to burns, surgery or in diseases, such as kidney disorders, liver disorders, hypercholesterolemia, diabetes mellitus, gout, and the like. A specific application is in the treatment and prevention of abesity which has been successfully treated with certain preferred compositions of the invention.
is The invention also camprises a novel palatable nutritional composition comprising a combination of a specific protein-free carbohydrate and specific protein-free polyunsaturated fat:
protein-free carbohydrate 70-95 wt.~
protein-free highly polyunsaturated vegetable fat 5-30 wt.'s These specific carbohydrate and specific polyunsaturated fat compositions may be used alone or in combination with the amino acid composition of the invention in amounts that vary according to the nutritional requirements 2S of the patient. This may vary between 12 Kcal to 60 Kcal per gram of amino acids.
The preferred ranges are from 80-90 wt.~, protein--free carbohydrate and 20-10 wt.o highly polysaturated vegetable fat and the especially preferred ranges are ~ respectively about 85 wt. ~ to about 15 wt.
The composition made by specific mineral-free, protein-free carbohydrate and specific highly polyunsaturated vegerable fat, in amounts relative to one another, will provide a apparent digestibility of at least 75~, preferably 5 80~ and most preferably 95~, and which will provide the - ~v;~,~: a O
highest apparent digestibility*(AD) and energy density of any natural food or dietetic composition. The mineral--free, protein-free carbohydrate and highly polyunsaturated vegetable fat composition will provide an exceptional high Energy Density, providing in the liquid form composition at least 4Kca1/cc = 3Kca1/g, preferably 4.4 Kcal/cc = 3.4Kca1/g, and high lipids' polyunsaturated/saturated (P/S) ratio, providing a P/S of a least 4.6, preferably 7.0 and most preferably 8.~., compared with any natural food or palatable 1Q dietetic composition. The composition may also contain vitamins and/or minerals.
The specific carbohydrate and specific polyunsaturated vegetable .fat compositions have particular use in providing energy and Essential Fatty Acids (EFA), for ~,S prevention or treatment of Protein-Calorie Malnutrition (PCM). In particular, the composition may be used when further energy and EFA .intake is required, and specifically as a complement of amino acid composition intake for supportive nutrition in the case of trauma due to burns, z0 surgery or in disease, such as renal disorders, liver disorders, diabetes mellitus, gout, and the like.
The specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention may be utilized as a complement, in the prevention and ~ treatment of Protein-Calorie Malnutrition (PCM) as a supplement and/or substitute of carbohydrate and/or fat of the regular diet. In particular, the compositions may be used as a nutritional complement in conditions such as:
Protein-Calorie Malnutrition (PCM), cystic fibrosis, anorexia 30 nervosa, immunodeficiency caused by malnutrition, treatment and prevention of malnutrition in AIDS patients, gout, hepatic disorders, burrs therapy, renal disorders, alcoholism *EIeymfield, S.D., Williams, P.J. in '°b9odern Nutrition In Health arid Disease°', Shils, M.E., Young, V.R. (Eds), page 819, Lea & Febiger, Philadelphia 1988.
Human nutrition requires a source of the components of protein, carbohydrates, lipids, vitamins and minerals.
Many and varied sources for these nutrient materials have been utilized in the prior art. The prior art does not disclose the concept of providing a balanced supply of nutrients which permits substantially complete absorption of the nutrients which are administered to an individual.
Proteins are associated with all forms of life, an observation that dates back to the original identification of protein as a class by Mulder in 1838. The proteins of living matter act as organic catalysts (enzymes), as structural features of the cell, as messengers (peptide hormones), and as antibodies. The importance of protein in the diet is primarily to act as a source of amino acids, some of which are essential (indispensable) dietary constituents because their carbon skeletons axe not synthesized in the bodies of animals, It is known that the adult human requires eight amino acids which are essential .for the maintenance of good health. These amino acids are isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine.
Amino acid solutions are commercially available for ~ nutrient I.V. feeding of post operative patients, pediatric patients, patients with renal failure and patients with hepatic failure. The available amino acid I.V. solutions are based on crystalline amino acids which have an advantage over the amino acids solutions which were obtained by hydrolysis of proteins such as fibrin or casein. These solutions were nutritionally incomplete in the amino acid content and caused toxic reactions which led to the banning of these solutions in the United States by the Food and Drug Administration.
Amino acid solutions are available which contain ~ all of the essential amino acids in combination with ~~~~~s 8 .. 2 _ non-essential amino acids, with or without vitamins, minerals and a carbohydrate and fat source.
To estimate the nutritional value of protein as well as amino acid formulas, the accepted methodology is to determine, during the ingestion of a proteins) or an amino acid formula, the subject's nitrogen balance. This represents the difference between nitrogen intake and nitrogen output, the difference being either positive (nitrogen retention, as in active growth), negative (nitrogen loss), or zero (nitrogen equilibrium).
In order to carefully determine nitrogen balance (nitrogen intake - nitrogen output), I have used the formula:*
= T - (U + F + S)*
where:
B = Nitrogen Balance I - Nitrogen Intake U = Nitrogen Loss In Urine F = Nitrogen Loss In Feces S = Nitrogen Dermal Losses This formula has been used to compute the Net Nitrogen Utilization (NNU) for the amino acid formulas and proteins that were tested.
The prior art amino acid solutions, which have widely different ratios of the component amino acids, have not been found to be suitable as total nutrient compositions because after prolonged reliance on these compositions, symptoms of nutrient deficiency are detected due to the low percentage of their net nitrogen utilization (NNU). The low ~ net nitrogen utilization (NNU) results in the presence of unabsorbed amino acids, which are deaminated and cause an increased production of blood urea nitrogen (BUN) as well as * Munro, H.N., Crim M.C., in "Modern Nutrition In Health and Disease" Shils, M.R., Young, V.R. (Eds), page 24, Lea &
g5 Febiger, Philadelphia 1988 2~~~~~~~
increased levels of other metabolic nitrogen containing products. This problem is particularly difficult with patients who have renal failure and/or hepatic disorders.
United States Letters Patent No. 3,697,287 disclose an amino acid food composition which is described as a palatable mixture of the essential and non-essential amino acids, minerals, vitamins, carbohydrates and fats. That composition contains essential and non-essential amino acids.
The essential amino acids in such a composition are present in the following ratios:
L-valine 1.0 L-arginine 1,77 L-isoleucine ,g1 L-lysine 1.03 L-phenylalan.ine 1.03 L-histidine .44 L-leucine 1,43 L-methionine ,g3 L-threonine ,g1 L-tryptophan .28 I have discovered that the use of an amino acid composition which contains specific proportions of the essential amino acids will make possible a higher NNU as compared to high NNU protein such as hen whole egg protein or other amino acid compositions. I have discovered that the oral administration of a composition which consists of essential amino acids will result in a higher NNU as compared to compositions which also include non-essential amino acids.
In addition, the use of a preferred embodiment of the invention, will avoid causing or unduly exacerbating the BUN
of patients in which the nitrogen intake is required to be restricted who are fed with certain of the applicant°s composition. The avoidance of exogenous residual nitrogen is achieved by the formulation of the amino acid composition with a specific ratio of the essential amino acids which provide for substantially complete absorption of the required quantity of the amino acids. The novel amino acid composition of the invention may be utilized alone or in combination with carbohydrates, lipids, vitamins and minerals depending on the particular nutrient requirements of a particular patient.
I have also discovered that the feeding of the amino acid composition of the invention has a profound immunostimulant effect which can be determined by the means of objective clinical criteria.
1~ The main function of dietary carbohydrate is to provide energy. Administration of carbohydrate has long been known to spare protein in early fasting.
Protein is abruptly lost upon initiating a fast or upon withdrawing carbohydrates from an adequate diet (even if replaced isoenergetically by fat). Glucose is the main carbohydrate in the body arid although glucose can be utilized by all cells, it is essential only in a few organs, including the brain and the red cells. Although glucose can be converted to fat, it should be noted that fat cannot be converted to glucose. All the dietary carbohydrates seem to reduce the level of high-density lipoprotein (HDL) cholesterol in the serum, and HDL cholesterol.:total cholesterol ratio in the serum is reduced to a greater extent by sucrose than by glucose. The type of dietary carbohydrate can alter the 2S level of triglyceridemia, and this effect can be negated by the addition of polyunsaturated fat to the diet.
Dietary lipids consist mainly of triglycerides (TG), a useful and concentrated source of energy. An adequate TG supply and absorption are especially important for infants and also for adults with a high energy requirement, such as patients with major burns, malignant tumors, and surgical wounds. The alternative energy sources, protein and carbohydrates, deliver per gram, 4 FCcal, less than half the energy density of fats, and require bulky meals to cover high energy requirements. Essential Fatty Acids (EFA) are ~~~~:~v~3 necessary for the normal function of all tissues, it is therefore not surprising that the list of symptoms of EFA
deficiency is a long one. As no animal, including man, can synthesize EFA, it is completely dependent on vegetable lipids to meet EFA requirements.
It has been demonstrated convincingly that diets enriched in EFA such as linoleic acid and reduced in saturated fatty acids do lower significantly LDL and VLDL
cholesterol in man at both 30 and 40 in ~ of fat levels (3).
I have discovered that the oral administration of a composition which contains specific proportion of protein-free carbohydrate and protein-free polyunsaturated vegetable fat results in a palatable mixture having the highest apparent digestibility (AD) a higher Energy Density per weight and per volume and a higher content in EFA joined with a lower content in saturated tatty acids of any natural food or palatable dietetic composition for use as a complement in feeding patients such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism, and/or fail to eat, because of a physiological and/or psychological lack of appetite.
Each dietary fuel differs in apparent digestibility (~), which is calculated as:
(Intake-Stool losses) x 100 Intake To illustrate: If 100 grams of fat are ingested per day, and if the daily stool fat averages 5 grams, then the "apparent digestibility" (AD) of fat is 95~.
I have discovered that the oral administration of a composition which contains specific proportion of mineral-free, protein-free carbohydrates) and highly polyunsaturated vegetable fats) with the highest content in EFA join with the lowest content in saturated fatty acids, results in a palatable mixture which will avoid causing or unduly ,.. Y.7 4,a~ ~,~
_ 6 O
exacerbating the level of High-Density Lipoprotein (HDL), Low-density-Lipoprotein (LDL) and Very Low-Density-Lipoprotein (VLDL) cholesterol in the serum of patients in which HDL, LDL
and VLDL cholesterol level is required to be restricted who are fed with certain of the appl.icant's composition.
I have also discovered that the oral administration of a composition which contains specific proportion of mineral free, protein-free carbohydrate and highly polyunsaturated vegetable fat results in a palatable mixture which will avoid causing or unduly exacerbating the Blood Urea Nitrogen (BUN) of patients in which nitrogen intake is required to be restricted who are fed with certain of the applicant's compositions.
I have also discovered a novel concept for providing vitamin and mineral requirements by means of a method which is based on the administration o.f an amount of vitamins and minerals which is proportionate to the amount of amino acid which are administered.
I also discovered an object of the invention to provide an improved palatable mineral Free protein-free carbohydrate and highly polyunsaturated vegetable fat based nutrient composition.
It is also an abject of the invention to provide a palatable protein-free carbohydrate and protein-free polyunsaturated fat based composition which is useful because of its highest apparent digestibility (AD) and energy density (ED) in the nutritional support of patients suffering from disease where restricted nitrogen intake is indicated such as in certain renal and hepatic dysfunctions.
~0 It is also an object of the invention to provide a palatable mineral-free protein-free carbohydrate and protein-free highly polyunsaturated vegetable fat based composition a higher apparent digestibility (AD) and energy density (ED) content and a higher EFA content joined with a lower saturated fatty acid content of any natural food -or palatable dietetic composition for use as a supplement in feeding patients such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism, and/or who fail to eat, because of a physiological and/or psychological lack of appetite.
It is also an object of the invention to provide a mineral-free, protein-free carbohydrate and highly polyunsaturated vegetable fat based composition which has the advantage of low storage and shipping cost which may be used as an emergency food to be shipped by air in response to catastrophic events.
SUMMARY OF THE INVENTION
In a broad aspect, the present invention relates to a nutritional composition comprising a combination of the following:
(a) isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine in amounts relative to one another which will provide a Net Nitrogen Utilization (NNU) of at least 80%;
(b) a carbohydrate selected from the group consisting of sucrose, maltose and sorbitol, and a highly polyunsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil; and (c) for each gram of amino acid, an amount of vitamins which is equivalent to the following:
Vitamin A 60.02 - 109.0 mcg Vitamin D 37.0 - 63.0 mcg Alpha-tocopherol 0.78 - 1.30 mg Vitamin K 2.0 - 4.0 mcg Vitamin B1 10.0 - 20.0 mcg Vitamin Bz 27.0 - 48.0 mcg - 7a -Nicotinamide 0.13 - 0.23mg Pantothenic Acid 0.18 - 0.30mcg Vitamin B6 13.0 - 23.0mcg Biotin 0.43 - 0.73mcg Folic Acid 3.5 - 6.5 mcg Vitamin B12 35.0 - 65.0ng Vitamin C 3.5 - 6.5 mg The invention comprises a novel amino acid composition comprising a combination of the following essential amino acids:
isoleucine;
leucine;
lysine;
methionine;
phenylalanine;
threonine;
tryptophan; and valine in amounts relative to one another which will provide a net nitrogen utilization (NNU) of at least 75%, preferably 80% or 90% and most preferably 950. The composition may also contain carbohydrates, Essential Fatty Acid (EFA) sources, vitamins and/or minerals.
The amino acid composition has particular use in providing essential nutrients for the prevention or treatment of Protein-Calorie Malnutrition (PCM), in feeding patients _8_ such as infants, alcoholics, drug abusers, Acquired Immune Deficiency Syndrome (AIDS) patients, Aids Related Complex (ARC) patients, cancer patients, psychiatric patients, geriatric patients and the like, who have an increased catabolism and/or who .fail to eat, because of a physiological and/or psychological lack of appetite.
In particular, the amino acid composition may also be used for supportive nutrition in the case of trauma due to burns, surgery or in diseases, such as kidney disorders, liver disorders, hypercholesterolemia, diabetes mellitus, gout, and the like. A specific application is in the treatment and prevention of abesity which has been successfully treated with certain preferred compositions of the invention.
is The invention also camprises a novel palatable nutritional composition comprising a combination of a specific protein-free carbohydrate and specific protein-free polyunsaturated fat:
protein-free carbohydrate 70-95 wt.~
protein-free highly polyunsaturated vegetable fat 5-30 wt.'s These specific carbohydrate and specific polyunsaturated fat compositions may be used alone or in combination with the amino acid composition of the invention in amounts that vary according to the nutritional requirements 2S of the patient. This may vary between 12 Kcal to 60 Kcal per gram of amino acids.
The preferred ranges are from 80-90 wt.~, protein--free carbohydrate and 20-10 wt.o highly polysaturated vegetable fat and the especially preferred ranges are ~ respectively about 85 wt. ~ to about 15 wt.
The composition made by specific mineral-free, protein-free carbohydrate and specific highly polyunsaturated vegerable fat, in amounts relative to one another, will provide a apparent digestibility of at least 75~, preferably 5 80~ and most preferably 95~, and which will provide the - ~v;~,~: a O
highest apparent digestibility*(AD) and energy density of any natural food or dietetic composition. The mineral--free, protein-free carbohydrate and highly polyunsaturated vegetable fat composition will provide an exceptional high Energy Density, providing in the liquid form composition at least 4Kca1/cc = 3Kca1/g, preferably 4.4 Kcal/cc = 3.4Kca1/g, and high lipids' polyunsaturated/saturated (P/S) ratio, providing a P/S of a least 4.6, preferably 7.0 and most preferably 8.~., compared with any natural food or palatable 1Q dietetic composition. The composition may also contain vitamins and/or minerals.
The specific carbohydrate and specific polyunsaturated vegetable .fat compositions have particular use in providing energy and Essential Fatty Acids (EFA), for ~,S prevention or treatment of Protein-Calorie Malnutrition (PCM). In particular, the composition may be used when further energy and EFA .intake is required, and specifically as a complement of amino acid composition intake for supportive nutrition in the case of trauma due to burns, z0 surgery or in disease, such as renal disorders, liver disorders, diabetes mellitus, gout, and the like.
The specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention may be utilized as a complement, in the prevention and ~ treatment of Protein-Calorie Malnutrition (PCM) as a supplement and/or substitute of carbohydrate and/or fat of the regular diet. In particular, the compositions may be used as a nutritional complement in conditions such as:
Protein-Calorie Malnutrition (PCM), cystic fibrosis, anorexia 30 nervosa, immunodeficiency caused by malnutrition, treatment and prevention of malnutrition in AIDS patients, gout, hepatic disorders, burrs therapy, renal disorders, alcoholism *EIeymfield, S.D., Williams, P.J. in '°b9odern Nutrition In Health arid Disease°', Shils, M.E., Young, V.R. (Eds), page 819, Lea & Febiger, Philadelphia 1988.
3~
_ 10~ _ t.~ i .C
rehabilitation, tuberculosis, pre and post surgery, hospitalized patients' diet, neurological disorders patients, cancer patients, chronic diseases, illicit-drug rehabilitation, malabsorption, food allergy, diarrhea, S diabetes mellitus, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly.
The specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention are of special utility in providing nutritional complement to patients suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC) in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor or marasmus and the like.
If desired the specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention may be used as supplement/replacement compositions for use in providing and/or enhancing a basic source of nutrition for infants, children and adults. It is of particular utility in geriatric 2d patients.
The composition may be given as a solution in water, or as a dispersion in a suitable liquid, or semisolid medium.
The specific protein-free carbohydrate and 2S protein-free polyunsaturated fat are those which provide an apparent digestibility (AD) of at least 75$. Using this parameter of evaluation, it is possible using the compositions and methods of the present invention to obtain at least 90~
AD and through the use of preferred embodiments up to 99~ AD.
The exceptional high AD and energetic (Energy Density) content, per weight and per volume, are obtained because of the extremely high absorption rates that are possible because of the particular compositions devised by the applicant.
~S
f 3 _ 11_ ~~'':,!~rt?
DETAILED DESCRIPTION OF THE INVENTION
The amino acid composition of the invention is based on the use of crystalline amino acids in specific relative amounts which provide an net nitrogen utilization (NNU) of at least 75~. For example, if a particular subject who is fed which an amino acid formula has a nitrogen intake of 100.0 g. and a total nitrogen output of 100.0 g., the NNU
of the formula is 100'x. If the subject's nitrogen intake is 100 and the output is 128, then the NNU of the formula is 72$.
Using this parameter of evaluation, it is possible using the compositions and methods of the present invention to obtain at least 90~ NNU and through the use of preferred embodiments up to 100$ NNU.
],$ The exceptionally high NNU are believed to be obtained because of the extremely high absorption rates that are possible because of the particular compositions devised by the applicant.
The amino acid composition of the invention 20 comprise those having the following proportions of amino acids in grams per 10 grams of composition:
(a) from 1.217 to 1.647 isoleucine;
(b) from 1.827 to 2.735 leucine;
(c) from 1.260 to 2.359 lysine;
2S (d) from 0.232 to 0.778 methionine;
(e) from 0.843 to 1.314 phenylalanine;
(f) from 0.970 to 1.287 threonine;
(g) from 0.208 to 0.467 tryptophan; and (h) from 1.260 to 1.900 valine.
-12 - ~i~~~s?~
(I) isoleucine 1.217 - 1.530 leucine 1.827 - 2.735 lysine 1.260 - 2.078 methionine 0.232 - 0.778 phenylalanine 0.934 - 1.314 threonine 0.970 - 1.287 tryptophan 0.208 -0.467 valine 1.391 - 1.900 (II) isoleucine 1.251 1.647 leucine 1,846 - 2.130 lysine 2,023 - 2.359 methionine 0.490 - 0.778 phenylalanine 0.843 - 1.144 threonine 1.0S3 - 1.287 tryptophan 0.238 -0.401 valine 1,260 _ 1.426 (TII) ' isoleucine 1.289 -1.647 leucine 1.917 - 2.130 lysine 2.023 - 2.359 methionine 0.490 - 0.778 phenylalanine 0.843 - 1.144 threonine 1.053 - 1.271 tryptophan 0.238 -0.319 valine 1.342 - 1.426 3p r. ~, r;
~~~ ~;~ ~~3 _ 13, (IV) isoleucine 1.251 1.408 leucine 1.846 - 2.054 lysine 2.086 - 2.359 methionine 0.621 - 0,77g phenylalanine 0.969 - 1.144 threonine 1.106 - 1.287 tryptophan 0.293 - 0.401 valine 1.260 - 1.422 (V) isoleucine 1.372 - 1.530 leucine 1.827 - 2.539 lysine 1.550 - 2.078 methionine 0.490 - 0.708 phenylalanine 0.969 - 1.177 threonine 0.970 - 1.157 tryptophan 0.208 -0. 373 valine 1.422 - 1.600 zo (vz) isoleucine 1.2,17 1.530 leucine 1.952 - 2.735 lysine 1.260 - 1.999 methionine 0.232 - 0,778 phenylalanine 0.934 - 1.314 threonine 1:043 - 1.287 tryptophan 0.266 -0.467 valine 1.391 - 1.900 ~5 _ m_ cull) isoleucine 1.372 - 1.445 leucine 2.192 - 2.539 lysine 1.550 - 1.770 S methionine 0.490 - 0.642 phenylalanine 0.969 - 1.155 threonine 0,970 - 1.052 tryptophan 0.282 -0.319 valine 1.486 - 1.571 (VIIT) isoleucine 1.451 - 1.530 leucine 1.827 _ 1.846 lysine 2.020 - 2.078 methionine 0.490 - 0.642 phenylalanine 0.969 - 1.144 threonine 1.115 - 1.157 tryptophan 0.368 - 0.373 valine 1.422 - 1.483 (Ix) isoleucine 1.328 - 1.357 leucine 1.917 - 1.951 lysine 2.086 - 2.250 2S methionine 0.642 - 0.673 phenylalanine 0.969 - 1.144 threonine 1.196 - 1.287 tryptophan 0.333 - 0.340 valine 1.342 - 1.422 ~~~.~~,~
(X) isoleucine 1.366 - 1.408 leuc ine 1. 84 - 1 , 917 lysine 2.267 - 2.359 methionine 0.674 - 0.778 phenylalanine 0.969 - 1.144 threonine 1.106 - 1.157 tryptophan 0.311 - 0.333 valine 1.260 - 1.313 (XI) isoleucine 1.289 ~ 1.647 leucine 1.917 - 2.130 lysine 2.023 - 2.359 methionine 0.622 - 0.778 phenylalanine 0.843 - 0.988 threonine 1.053 - 1.271 tryptophan 0.238 -- 0.298 valine 1.342 - 1.426 (xzx) isoleucine 1,251 - 1.328 leucine 1..950 - 2.067 lysine 2.078 - 2.315 methionine 0.490 - 0.689 phenylalanine 0.969 - 1.144 threonine 1.106 - 1.152 tryptophan 0.282 - 0.401 valine 1.306 - 1.422 3rD
~~ ~ ~ ~ 'i f"?
,r ;: !.r ~.3 !.~
Preferred compositions include the following proportions by weight of the amino acids:
(XIII) isoleucine 1.217 ~ 1.477 leucine 2.281 - 2.735 lysine 1.332 - 1.999 methionine 0.232 - 0.608 phenylalanine 0.934 - 1.136 threonine 1.043 - 1.287 tryptophan 0.304 - 0.467 valine 1.391 - 1.900 (XIV) 15 isoleucine 1.408 - 1.530 leucine 1.952 - 2,077 lysine 1.260 - 1.521 methionine 0,674 - 0.778 phenylalanine 1.257 - 1.314 20 threonine 1.106 - 1.146 tryptophan 0.266 -0.373 valine 1.581 - 1.700 'fhe especially preferred compositions include those 2S having the follawing proportions by weight:
(z) (II) isoleucine 1.438 1.482 Ieucine 2.287 1.963 30 lysine 1.650 1.428 methionine 0.283 0.699 phenylalanine 0.943 1.288 threanine 1.226 1.111 tryptophan 0.448 0.368 35 valine 1.721 1.656 t' a ; ~' '~;3~~~,~(~
_ 17_ a ( IIT ) (_z~) isoleucine 1.310 1.341 leucine 2.053 1.922 lysine 2.189 2.144 methionine 0.621 0.651 phenylalanine 1.029 1.027 threonine 1.107 1.211 tryptophan 0.293 0.338 valine 1.390 1.358 (V) (VT) isoleucine 1.381 1.311 leucine 1.891 1.951 lysine 2.297 2.266 methionine 0.68?. 0.752 phenylalanine 1.029 0.959 threonine 1.113 1.119 tryptophan 0.318 0.256 valine 1.284 1.376 (VIT) (VIIT) isoleucine 1.443 1.484 leucine 2.226 1.832 lysine 1.760 2.064 methionine 0.556 0.580 phenylalanine 1.100 1.p67 threonine 1.041 1.136 tryptophan 0.317 0.371 valine 1.553 1.461 The compositions of the invention may be utilized in the prevention and/or treatment of nutritional and/or metabolic disorders in healthy or sick people as a supplement and/or substitute to the regular diet. Tn particular, the . °.s 18 -.
compositions may be used for nutrition in conditions such as:
Protein--Calorie Malnutrition (PCM), cystic fibrosis, anorexia nervosa, immunodeficiency caused by malnutrition, treatment and prevention of malnutrition in AIDS patients, gout, renal failure, hepatic disorders, burn therapy, hypovitaminosis, hypercholesterolemia, hypoalbuminemia, alcoholism, hemophilia, tuberculosis, pre and post-surgery, hospitalized patients° diet, neurologic disorders patients, pre-menstrual edema and nutritional losses of menstruation, neoplasms, chronic diseases, illicit-drug rehabilitation, malabsorption, food allergy, peptic ulcer, diarrhea, gastrointestinal disorders, short bowel syndrome, hyperlipidemia, diabetes mellitus, gall bladder disorders, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly, nutrition in convalesent patients and nutrition during athlete's training.
The amino acid composition of tk-xe invention is of special utility in providing nutrition to patients suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC). The composition of. the invention may also be used in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor, marasmus and the like.
If desired, the amino acid composition of the invention may be used to the treatment and prevention of obesity, or as a supplement/replacement composition for use in providing and/or enhancing a basic source of nutrition for infants, children and adults. It is of particular utility in geriatric patients.
In the treatment and prevention of obesity, as well as in the maintenance of optimal body weight it may be desirable to include decreasing amounts of a source of calories to avoid hypoglycemia. For example, in the first day may include 2000 Kcal and this may be decreased by 200 Kcal for each day to a minimum of 800 K/cal/day. For physician supervised diets in an institution, a diet without °
19 °
any substantial source of calories may be used after gradually decreasing amounts of a source of calories are used. The calorie content may be reduced to less than 100 Kcal may be used, if necessary.
It is possible to substitute cysteine for part of the methionine component; and to substitute tyrosine for part og the phenylalanine component.
The amino acid compositions of the invention have particular use in pregnancy because the proper requirement of protein is supplied without increasing Blood Urea Nitrogen (BUN) or other nitrogen metabolic residuals; in addition, its use prevents nutritional and metabolic disorders and their consequences during pregnancy and lactation.
The amount of the amino acid composition to be used in each particular condition may generally be determined by titration of individual patients to obtain the desired nutritional response or by use of from 0.5 g to 5.0 g/kg of ideal body weight/per day of the amino acid composition of the invention, and preferably .from 1.0 g to 2.0 g/kg of body ideal weight/per day given orally or parenteraly. Certain of the compositions of the invention may be used intravenously, however, the preferred route of administration is orally via normal feeding or by a stomach tube because absorption is higher and the nosocomial infections associated with intravenous feeding may be avoided. The amino acid composition may be administered dry as a powder, in capsules or tablets, as a.
solution or dispersion in a suitable liquid, or in a semi-solid medium. The ideal weight is determined according to the method set forth in Example I.
0 The mineral-free, protein-free carbohydrate and highly polyunsaturated vegetable fat composition of the invention is based on the use of specific mineral-free, protein-free carbohydrates) and mineral-free, protein-free highly polyunsaturated vegetable fat(s), which will provide 5 an exceptional high AD, providing an apparent digestibility _ 20 _ of at least 75$, preferably 80~ and most preferably 95~.
The use of mineral-free, protein-free carbohydrates) is in the form of the alcohol of glucose, namely sorbitol (glucitol), and/or disaccharides, namely sucrose, and/or maltose. Sorbitol has a therapeutic value as a replacement carbohydrate in the diet of diabetics; sucrose is perhaps the most common and best known disaccharide in the diet, and maltose, which has a relative sweetness value of 40, can replace all or part of the sucrose contents to decrease the sweetness of the composition, and make it more palatable.
The use of mineral-free, protein-free vegetable fat is in the form of vegetable oils with a polyunsaturated/
saturated ratio (P/S ratio) of a least 4.6, preferably 7.0 and most preferably 8.2. The use of vegetable oils with a very high (more than 4.5 P/S ratio), namely safflower oil (8.2 P/S ratio, and/or sunflower oil (7.0 P/S ratio), and/or corn oil (4.6 P/S ratio)(5), is because has been demonstrated convincingly that diets enriched in EFA such as linoleic acid (highly present in safflower oil and/or sunflower oil and/or 24 corn oil) and reduced in saturated fatty acids do lower significantly LDL and VLDL cholesterol in man at both 30 and ~0 in $ of fat levels.
It is to be understood that one or more of the mineral-free, protein-free carbohydrates may be used with one or more of the highly polyunsaturated vegetable fats to provide a composition having the desired flavor and calorie content. Distilled water or any other suitable mineral-free diluent may be added, as desired.
The exceptional high, AD of the nutritional composition of the invention, providing a carbohydra a and vegetable fat composition with an exceptional high apparent digestibility (AD), providing at least 75~, preferably 80~
and most preferably 95~ AD, and an exceptional high'Energy density, providing in the liquid form composition at least 4Kca1/cc (3Kca1/g), preferably ~.~ Kcal/cc (3.4 Kcal/g), and t ~~ ~~;.=~l~
most preferably 4.7 Kcal/cc (3.7 Kcal/g), and an exceptional vegetable fat P/S ratio, providing a P/S of at least 4.s, preferably 7.0 and most preferably 8.2 are obtained by the use of the applicants' compositions.
F'nrm" 1 ~ T
Maltose 70-95 wt.
Safflower Oil 5-30 wt.
TOTAL 100.0 wt.
ZO Fnrm"'1o TT
Maltose 70-95 wt.
Safflower Oil and 5-30 wt. $
Sunflower Oil TOTAL 100.0 wt.
15 (The safflawer oil and sunflower oil may comprise from 1-99 wt. ~ to 99-1 wt. ~ of the total oil content) Formula III
Sorbitol 70-95 wt. ~
Safflower Oil 5-30 wt. ~
as TOTAL 100.0 wt.
Formula IV
Sorbitol 70-95 wt. ~
Safflower Oil and 5-30 wt. ~
2S Sunflower oil TOTAL 100.0 wt. ~
(The safflower oil and sunflower oil may comprise from 1-99 wt. $ to 99-1 wt. ~ of the total oil content) 30 Formula V
Sucrose and 70-95 wt. g Maltose Corn Oil 5-30 wt. ~
TOTAL 100.0 wt. ~
9 ,. ~ ,.? (?
_ 22 Sucrose and 70-95 wt. $
Maltose Sunflower Oil 5-30 wt. $
TOTAL 100.0 wt. ~
Formula VII
Sorbitol and 70-95 wt. $
Maltose 1~ Safflower Oil 5-30 wt. $
TOTAL 100.0 wt' $
Formula VITI
Sorbitol and 70-95 wt. $
Maltose Safflower Oil and 5-30 wt. $
Sunflower Oil TOTAL 100.0 wt. $
(The safflower oil and sunflower oil may comprise from 1-99 wt' $ to 99-1 wt. $ of the total oil content) Formula IX
Sucrose, 70-95 wt.
Maltose and Sorbitol Safflower Oil, 5-30 wt. $
Sunflower oil and Corn Oil TOTAL 100.0 wt. $
(The safflower oil, sunflower oil and corn oil may comprise from Z-99 wt. $ to 99-1 wt, $ of the total oil content) Formula X
Sucrose, 70-95 wt. $
Maltose and Sorbitol Corn Oil 5-30 wt. $
TOTAL 100.0 wt. $
Vitamins are organic micronutrients essential for normal growth and maintenance of life. Vitamins cannot be synthesized by the organism and for these reasons they have to be supplied from an exogenous source. Vitamins provide the only source of certain coenzymes necessary for metabolism, the biochemical process that supports life. Vitamins are classified as fat-soluble and water-soluble. Fat-soluble vitamins, namely A, D, E, and K are stored in body fat and may therefore accumulate in quantities that can be toxic.
i0 The B vitamins and vitamin C are water-soluble and most of them are rapidly excreted in the urine and thus rarely cause toxicity. Vitamin C and B12 tend to be stored in the body.
Effects of vitamins) deficiency, as well, as, toxicity (excessive intake) are dangerous to health, and must i5 be avoided.
The inorganic nutritional minerals and trace elements present in food are essential for health. Some such as calcium, phosphorus, and potassium, occur in the body in concentrations 0.005. Others termed "trace elements'° such 20 as iron, zinc, and iodine, occur in much smaller concentrations ( O.OOS$).
The inorganic elements have many functions such as electrolytes, components of the bones and teeth, components of the prosthetic group of enzymes, and others.
Effects of minerals) deficiency, as well as, toxicity (excessive intake) are dangerous for health and must be avoided.
The preferred group of vitamins and minerals are set forth below. It should be understood that ~rariations in 30 the preferred group may be made but the essence of the applicant's inventive use of vitamins and minerals in the administration of these nutritional elements is in the use of a specific ratio of vitamins and minerals to the total amount of specific amino acids administered to a particular patient 35 taking into consideration the interrelationship - 24~ -specific amino acid(s), vitamins) and mineral(s). This is to allow high NNU, as well as, to avoid hypo or hypervitaminnosis (deficiency or toxicity).
Sodium 13.00 - 23.00 mg Potassium 41.00 - 69.00 mg Magnesium 2.50 - 5.00 mg Calcium 27.00 - 45.00 mg Manganese 1.50 - 3.50 mcg Iron 37.00 -100.00 mcg Cobalt 1.00 - 2.00 mcg Copper 35.00 - 65.00 mcg Zinc 0.16 - 0.28 mg Nickel 0.75 - 2.50 mcg Chromium 50.00 - 85.00 mcg I5 Molybdenum 0.70 - 5.00 mcg Vanadium 0.35 - 0.65 mcg Phosphorus 11.00 - 35.00 mg Chloride 30.00 - 50.00 mg Fluoride 13.00 - 22.00 mcg Iodine 4.00 - 8.00 mcg Selenium 2.00 - 4.50 mcg Bromine 0.07 - 0.13 mg Boron 4.00 - 8.00 mcg Silicon 22.00 - 40.00 mg Vitamin A 60.02 - 109.00mcg ' Vitamin D 37.00 - 63.00 ng Alpha- 0.78 - 1.30 ng Tocopherol Vitamin K 2.00 - 4.00 mcg Vitamin B1 10.00 - 20.00 mcg Vitamin B2 27.00 - 48.00 mcg Nicotinamide 0.13 - 0.23 mg Pantotenic Acid 0.18 - 0.30 mcg Vitamin B6 13.00 - 23.00 mcg Biotin 0.43 - 0.73 mcg fu ° 25 °
O
Fo1 is Ac id 3 . 50 - 6 . 50 mcg Vitamin B12 35.00 - 65.00 ng Vitamin C 3.00 - 6.50 mg The compositions of the invention may be given as dry as a powder, or as tablets, ar as a solution in water, or as a dispersion in a suitable liquid, or semi-solid medium.
The mineral--free, protein-free carbohydrate and highly polyunsaturated vegetable oil compositions of the 1~ invention may be utilized as a complement in the prevention and treatment of Protein--Calorie Malnutrition (PCM) or as a supplement and/or substitute of carbohydrate and/or fat of the regular diet. In particular, these compositions may be used for nutritional complement in conditions such as:
1~ Protein Calorie Malnutrition (PCM), cystic fibrosis, anorexia nervosa, immunodeficiency caused by malnutrition, tx'eatment and prevention of malnutrition in AIDS patients, hypercholesterolemia, gout, hepatic disorders, burn therapy, renal disorders, alcoholism rehabilitation, tuberculasis, pre and post surgery, hospitalized patients' diet, neurological disorders, cancer patients, chronic diseases, illicit-drug rehabilitatian, malabsorption, food allergy, diarrhea, diabetes mellitus, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly.
These compositions of the invention are of special utility in providing a nutritional complement to patients.
suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC).
The composition of the invention may also be used as a complement in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor or marasmus and the like.
If desired, the composition of the invention may be used as a supplement/replacement composition for use in 35 providing and/or enhancing a basic source of nutrition for ,_ ~~~,~.~,~'~t U
infants, children and adults. It is of particular utility in geriatric patients.
The amount of the composition to be used in each particular condition may generally be determinated in accordance of the energetic need of individual patients to obtain that desired nutritional response. The preferred route is the oral route, but a tube may be used for direct infusion into the alimentary tract.
When patients are treated with compositians i~ according to this invention, it is desirable to initially administer 10~ of the total calculated dose and to increase the dose by 10~ per day over a 10 day period. This is done to avoid gastrointestinal problems such as bloating and diarrhea.
The composition may be given as a solution in water, or as a dispersion in a suitable :Liquid, or semisolid medium.
It is to be understand that convention saurces of dietary fiber may be taken in combination with the compositions z0 of the invention, if desired. These sources include fruits, poyllium, bran, vegetables, etc.
is -z7-m E~L,AIriPLE 1 A comparative double-blind, triple cross-over study was carried out in sixty-six subjects, during a 114 day period, to examine subject's nitrogen balances to determine the net nitrogen utilization (NNU) of consumed protein or amino acid formula, during Diets A, B and C.
A group of 6F patients were fed with a Metabolism Equalizing and Stabilizing Diet (MESD) for a 30 day period.
The composition of the formula in grams per 10 grams of amino acids wasp Table Ile 1.438 Leu 2.
1~ Lys 1.650 Met 0.
Phe 0.
Thr 1.226 Trp 0.448 2o val 1.721 Sixty-six healthy subjects were fed with MESD, during the 30 day period, in the preliminary phase of this study, with the purpose of equalizing and stabilizing their 25 protein and energy metabolisms, thus avoiding different metabolism degrees, which could affect their nitrogen balances.
To avoid common errors in energy intake, which also could affect nitrogen balance, MESD supplied a constant ~~ energy intake per subject equivalent to 50 Kcal/Kg/day, during the 30 day period.
To avoid common errors in nitrogen intake, which could affect the nitrogen balance, the carbohydrate and fat of MESD were selected from the essentially protein-free 35 foods of Table IA.
Table IA, Food Com position x 100 Energy g Fruits: Protein (Calories) Apricot 0.8 57 Pineapple 0.4 52 Peach 0.8 52 Strawberry 0.8 36 Pondapple 0.4 52 Tangerine 0.7 43 Mango 0.5 5g Apple 0.3 58 Muskmelon 0.5 25 Orange 0.7 50 Loquat 0.2 44 ~5 Papaya 0.5 32 Pear 0.3 56 Watermelon 0.5 22 Vegetables:
Celery 0.8 19 Eggplant 1.0 27 Waxgourd 0.5 14 Chayote 0.9 31 Lettuce 1.0 13 25 Cucumber 0.7 15 Ripe tomato 0.8 21 Sweet Cassava 1.0 132 Carrot 0.8 41 Sucrose 0.0 384 Corn oil 0.0 384 Maltose 0:0 384 Sorbitol 0.0 384 35 Sufflower Oil 0.0 884 l ~ .1 _ 29 _ Sunflower Oil 0.0 884 Corn Oil 0.0 884 To avoid unnecessary nitrogen loss, and to stabilize subjects' protein metabolisms, MESD also supplied a decreasing amount of protein from the amino acid formula (Table I) during the 30 day period as follows:
(a) 1st and 2nd day: protein intake of 0.80 g/Kg/day;
(b) 3rd and 4th day: protein intake of 0.75 g/Kg/day;
(c) 5th and 6th day: protein intake of 0.70 g/Kg/day;
(d) 7th and 8th day: protein intake of 0.65 g/Kg/day;
(e) 9th and 10th day: protein intake of 0.60 g/K g/day;
(f) 11th and 12th day: protein intake of 0.55 g/Kg/day;
(g) 13th and 14th day: protein intake of 0.50 g/Kg/day;
15 (h) 15th and 16th day: protein intake of 0.45 g/Kg/day;
and (i) from the 17th to the 30th day: protein intake of 0.40 g/Kg/day.
The protein requirement was calculated for each 2p subject in accordance with each subjects ideal weight. The amino acid formula was fed .in three divided doses at 8:00 a.m.; 2:00 p.m. and 8:00 p.m. ~, vitamin-mineral supplement according to Example 4 was also fed to each patient.
After the MESD conclusion, at the beginning of the 2s main phase, the sixty-six healthy subjects were randomly divided into three matched groups, according to sex and number, and named Groups 1, 2 and 3. In accordance with the diet sequence (Table II), the main phase of this study, was conducted during three consecutive 28 day periods, with the purpose of examining subjects° nitrogen balances, in order to evaluate their net nitrogen utilization (NNU) of consumed protein and amino acid formulas, during the periods of Diets A, B and C .
Table II
Sequence of the Diets by Grou Group 1 MESD--_________A___________g___________~
Group 2 MESD-_-________B ___________C___________A
Group 3 MESD_-_________C___________A__________ -B
To achieve this purpose, Groups 1, 2 arid 3, each comprised of twenty_two healthy subjects, were fed with diets A, B, and C, following the obligatory sequence (Table II) and schedule (Table III).
T9hlo TTT
Sequence of Diets by Group and Period Group Group 2 Group First Period (28 days) Diet A B C
Second Period (28 days) DietB C A
Third Period (28 days) Diet C A B
Diets A, B, and C consisted of an identical composition of protein, carbohydrate, fat, vitamins and min erals, but of a different protein source. The diets had the following characteristics:
DTET "A" provided to the subject, a protein intake of 0.4 g/Kg/day, equivalent to 69 mg/Kg/day of nitrogen, from the amino acid formula of Table I and an energy intake of 50 Kcal/Kg/day, from protein-free carbohydrate and fat from Table IA.
DIET "B" provided to the subject a protein intake of 0..4 g/Kg/day, equivalent to s4 mg/Kg/day of nitrogen, from hen whole egg amino acid formula (Table IV) and an energy intake of 50 Kcal/Kg/day, from protein-free carbohydrate and fat from Table IA.
:~ ~ r~ ~.~ o - 31.
Table IV
Amino Acid Composition of Hen Whole Egg*
(Grams of amino acids in 1008 of protein) Arg 1.04 S Asp 7. 75 Cys-Cys 2.58 Glu 13.69 Gly 3. 91 His 2.65 Ile 7.35 Leu 9. 73 Lys 7.08 Met 3.46 Phe 6.39 1S Pro 4.69 Ser 9.29 Thr 5.50 Trp 1.82 Tyr 4.76 val a.21 Corn Oil and sucrose were added to the previous composition, in the following amounts, to provide an energy content in the form of fat and carbohydrate content that approximates that 2S of dried hen whole egg.*
Corn oil 90.00 g Sucrose 7.00 g The achievement of the equalization among formula compositions was obtained by adding to both Diet A - formula of Table I, and Diet B - hen whole egg amino acids formula of Table IV the amount of 0.9 g of fat (corn oil), plus 0.07 g *Basec3 on the data presented in Orr, M.D., and Watt; B.K., ~~~lno Acid Content of Foods" U.S. Dept. Agr., 1957.
;. ~ .,: c i a of carbohydrate (sucrose) per each gram of protein Content of the formulas, achieving an equivalent composition of protein, fat and carbohydrate as contained in the Diet C - dried hen whole egg as follows:
Dried Hen YJhole Egg Composition in 100g.*
Protein 47.0 g Fat 41.2 g Carbohydrate 3.4 g Kcal. 584 DIET "C°° provided to the subject a protein intake of 0.4 g/Kg/day, equivalent to 64 mg/Kg/day of nitrogen, from dried hen whole egg and an energy intake of 50 Kcal/Kg/day from protein-free carbohydrate and fat (Table IA).
To avoid common errors in determining nitrogen intake, which could affect the nitrogen balance, the carbohydrate and fat of Diets A, B and C were substantially protean-free (Table IA).
To avoid common errors in determining energy intake, which could also affect nitrogen balance, Diets A, B
and C supplied a constant energy intake per subject equivalent to SO Kcal/Kg/day, during each 28 day period.
To avoid over-estimating nitrogen intake, caused by unconsumed daily protein or amino acids formula during each 28 day period, all sixty-six subjects were fed three times per day (8:0o a.m.; 2:00 p.m.; and 8:00 p.m.) achieving the total consumption of their allotted formula.
To avoid error in determining energy intake, which could affect nitrogen balance, formulas given during Diets A, B and C had an equivalent composition of protein, fat and carbohydrate, which provided the same energy intake.
The identification by the subject of his/her formula by its flavor which could affect the double-blind characteristic of the sutdy was prevented by adding to the * INCAP-ICNND Composition of Foods, 1961.
~~'~~=~ J
- 33 °
formulas of Diets A, B and C a common fru it shake. To avoid errors in energy intake, this fruit shake, by itself, provided the same energy intake. The fruit for the shake was changed almost daily, and was chosen from Table V.
Table ~1 Food Composition x 100 Energy g Fruits Protein (Calories) Pineapple 0.4 52 Pondapple 0.4 52 Papaya 0.5 32 Watermelon 0.5 22 To avoid a nitrogen over-intake per g/kg/day, which could affect the nitrogen balance, the subject's protein requirement was based on his/her ideal weight. A daily vitamin-mineral supplement according to Example 4 was given to all subjects.
Determining Weight The subject's weight (in kg) was determined, in the early morning after subject's urination and evacuation, and before breakfast. The result was rounded off to the nearest 0.100 kg (range 50 g).
Determining Ideal Weight The subject's ideal weight (in kg) was obtained by subtracting factor 100 from the subject's height (in cm), then multiplying the result by either factor 0.9 (male) or 0.8 (female), in accordance with subject's sex. The result was rounded off to the nearest 0.500 kg (range 250 g). The following formula was applied:
male's ideal weight = ((Height - 100) x 0.9] kg female°s ideal weight = [(Height - 100 x 0.8] kg iJ
_ ~4 _ Determining Nitrogen Balance To determine the subject's nitrogen balance, the following formula was used:
B = I - ( U + F + S ) where:
B = N balance;
I = N intake;
U = N loss in urine;
F = N loss in feces; and S = N dermal losses.
The nitrogen balance represents the difference between N intake (T), and N output (U + F + S), the difference being either positive (N retention), as in active growth, negative (N loss), or zero (N equilibrium).
Determining Nitrogen zntake To determine the subject's nitrogen intake (I), the following formula is used:
Diet protein amount = Dietary nitrogen x 6.25 where use of factor 6.25, implies that the average protein contains 16~ nitrogen.
Determining Nitrogen Loss The urine (U) and feces (F), of each subject are collected throughout each 24--hour day of each consecutive 28 day period, to determine the nitrogen lass by micro-.Kjeldahl techniques.
To determine the subject's nitrogen dermal and minor route losses (S), a constant factor was used:
30 (S) = 5 mg x subject weight (kg) x day _35 _ ~~~~xyt~ot Determining Nitrogen Balance This calculation was made by taking into consideration the subject's real weight. To avoid any misinterpretation in the subject's daily nitrogen balance, which is not usually constant, the subject's diet nitrogen intake (I) per period, and the diet nitrogen output (U + F + S) per period, were obtained by adding up the subject daily nitrogen intake and output amounts, during the diet period.
The subject's nitrogen balance was obtained by the difference between the dietary nitrogen intake (I) per period, and the dietary nitrogen output (U + F + S) per period.
Determining Mean Nitrogen Loss The mean of each subject's nitrogen loss, per period, was obtained by adding up each subject nitrogen loss amount during a diet period, and dividing the result by the total number of subjects.
Determining Mean Protein Loss The mean protein loss per each subject per period, is obtained by multiplying the mean nitrogen loss per period by factor 6.25, All calculations were in accordance with the following formula:
PROTEIN = (N g) x 6.25 where it is assumed that the N content of the mixed proteins of the body is 16~. Thus 1 g of N excreted represent a loss from the body of 6.25 g of mixed proteins.
Determining Mean Tissue Loss The mean tissue loss per subject per period, is obtained by multiplying the mean protein loss per period by factor 5. All calculations are in accordance with the following formula:
LEAN TISSUE = (N g) x 6.25 x 5 ,36 ~ ~~«~H ,.
To illustrate: the N content of the mixed proteins of the body is 16~. Thus 1 g of N excreted represents a loss from the body of 6.25 g of mixed proteins. Intracellular protein exists in approximately a 20 to 25~ aqueous solution in the lean tissue of the body (the fat-free, connective tissue-free, and bane-free "wet" tissue).
P.ssuming that 1 g protein is associated with 5 g of hydrated lean tissue, then 1 g of excreted nitrogen represents a loss of 1 x 6.25 x 5 = 31.25 g of lean tissue.
Determining Mean NitrogenLoss Per Kilo Per Period The subjects' mean nitrogen loss per sub ect j per kg per period, is obtained by dividing the subjects' mean nitrogen loss per period by the mean ideal weight.
is Determining Range of Mean Nitrogen Loss Per Kilo Per Period The subjects' range of mean nitrogen loss per subject per kg per period, is obtained by calculating the difference between the highest and lowest subject°s nitrogen loss per period.
zs ~o 37 _ RESULTS OF THE STUDY
GROUP "1" NITROGEN BALANCE RESULTS BY DIET
Diet A B C
Group 1 equilibrium negative negative The following are the nitrogen balance results obtained from Group °'1°' comprised of twenty-two subjects, with a mean ideal weight of 55 kg, during each 28 day diet period:
DURING DIET "A"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM*
Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
i5 Mean Lean Tissue Loss per subject per period: NONE
DURING DIET "B"
Period: 28 days Subjects: 22 NITRQGEN ubject per period: NEGATIVE*
BALANCE
per s MeanNitrogen Loss subject per period: 28,56 g per Mean Nitrogen Loss kg per period: 519 mg per Mean Protein Lass subject per period: 178.50 g per Mean Lean Tissue Lossper subject per period:892.50 g ~S DURING DIET "Cn Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: NEGATIVE*
Mean Nitrogen Loss per subject per period: 32.78 g Mean Nitrogen Loss per kg per period: 596 mg Mean Protein loss per subject per period: 2p~~,87 g Mean Lean Tissue Loss per subject per priori: 1,02.37 g *found in all twenty two subjects.
3 8 ~ ~ ',-~~~ ~ ;i' .;
GROUP "2'° NTTROGEN BALANCE BY DTET
Diet B C A
Group 2 negative negative equilibrium The following are the nitrogen balance results obtained from Group "2" comprises of twenty-two subjects, with mean ideal weight of 53.5 kg, during each 28 day diet period:
DURING DIET "B°' Period: 28 days Subjects: 22 NITROGEN ubject per period: NEGATIVE*
BALANCE
per s Mean Nitrogen Loss subject per period: 26.51 g per Mean Nitrogen Lass kg per period: 495 mg per Mean Protein Loss subject per period: 165.68 g per Mean Lean Tissue Lossper subject per period:828.93 g DURTNG DIET "C"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: NEGATIVE*
ZO Mean Nitrogen Loss per subject per period: 30.47 g Mean Nitrogen Loss per kg per period: 569 mg Mean Protein Loss per subject per period: 190.43 Mean Lean Tissue Loss per subject per periad: 952.18 g DURING DIET "A"
Period: 28 days ~ Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM*
Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per priod: NONE
*found in all twenty-two subjects.
3 9 - ~ ~ 'a ,!~ ~ ;P
a~ ~, .~ :~
GROUP "3" NITROGEN BALANCE BY' DIET
Diet C A
B
Group 3 negative equilibrium negative S The following are the nitrogen balance results obtained from Group "3" comprises of twentydtwo subjects, with a mean ideal weight of 53 kg, during each 28 day diet period:
DURING DIET °°C"
Period: 28 days Subjects:
NITROGEN ubject ger period:NEGATIVE*
BALANCE
per s Mean Nitrogen Loss subject period: 30.43 g per Mean Nitrogen Loss kg per period: 574 mg per Mean Protein Loss subject per period:190.18 g per 1S Mean Lean Tissue Lossper subject per iod: 950.93 g per DURING DIET '°A"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM
20 Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per period: NONE
DURING DIET "B"
2S Period: 28 days Subjects: 22 NITROGEN BALANCE per ubject per period: NEGATIVE *
s Mean Nitrogen Loss per subject per period: 26.57 g Mean Nitrogen Loss per kg per period: 501 mg Mean Protein Lass per subject per period: 166.06 g 30 Mean Lean Tissue Lossper subject per period:830.31 g *found in all twenty-two subjects.
NITROGEN BALANCE BY GROUP AND DIET
Diet A B C
Group 1 equilibrium negative negative Group 2 equilibrium negative negative Group 3 equilibrium negative negative The following are the nitrogen balance results obtained from the sixty-six subjects belonging to Groups 1, 2, and 3, with a mean ideal weight of 54 kg, during each consecutives 28 day diet period:
1~ DURING DIET "A"
Period: 28 days Subjects: 66 NITROGEN BALANCE per subject per period: EQUILIBRIUM
Mean Nitrogen Loss per subject per, period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per period: NONE
DURTNG DIET "B"
Period:28 days Subjects: 66 NITROGEN NCE per ubject per period: NE GATIVE*
BALA s Mean NitrogenLoss subject per period: 27.21g per Mean NitrogenLoss kg per period: 504 m per 9 Range o.f NitrogenLoss per kg per period: 27 mg Mean Mean ProteinLoss subject per period: 170.06g per Mean Lean sue Lossper subject per period: 850.31g Tis DURING DIET "C"
Period:28 days Subject: 66 NTTROGEN NCE per subject per period: NEGATIVE
BALA
Mean NitrogenLoss per subject per period: 31.22 g Mean NitrogenLoss per kg per period: 578 mg Range of MeanNitrogen Loss per kg per period: 28 mg Mean ProteinLoss per subject per period: 195.12g Mean Lean sue Loss per subject per period: 975.62g Tis *found in all sixty-six subjects.
_ 41_. _ 2~:3~ , .~ .;: ~~ ae ~
a The sixty-six subjects have shown:
(a) the highest net nitrogen utilization (NNU) when receiving the formula of Table I, during Diet A periods, by achieving "equilibrium" in their nitrogen balances;
(b) a lower net nitrogen utilization (NNU) when receiving hen whole egg amino acids formula, during Diet B
periods, by obtaining negative nitrogen balances, with a mean nitrogen loss per subject equivalent to 504 mg/kg/period, which was 28$ less net nitrogen utilization (NNU) than when receiving the formula of Table I during Diet A; and (c) the lowest net nitrogen utilization (NNU) when receiving dried hen whole egg, during Diet C periods, by obtaining negative nitrogen balances, with a mean nitrogen loss per subject equivalent to 578 mg/kg/period, which was 32~ less apparent protein digestibility than when receiving the formula of Table I during Diet A periods.
The hen whole egg protein has been considered to be the protein food with the highest net nitrogen utilization (NNU). The formula of Table T has shown the highest net ~0 nitrogen utilization (NNU)~ by all sixty-six subjects, than both hen whole egg and hen whole egg amino acid formula. It can be concluded that the formula of Table I has a higher apparent protein digestibility than hen whole egg protein.
_ 10~ _ t.~ i .C
rehabilitation, tuberculosis, pre and post surgery, hospitalized patients' diet, neurological disorders patients, cancer patients, chronic diseases, illicit-drug rehabilitation, malabsorption, food allergy, diarrhea, S diabetes mellitus, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly.
The specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention are of special utility in providing nutritional complement to patients suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC) in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor or marasmus and the like.
If desired the specific carbohydrate and specific polyunsaturated vegetable fat compositions of the invention may be used as supplement/replacement compositions for use in providing and/or enhancing a basic source of nutrition for infants, children and adults. It is of particular utility in geriatric 2d patients.
The composition may be given as a solution in water, or as a dispersion in a suitable liquid, or semisolid medium.
The specific protein-free carbohydrate and 2S protein-free polyunsaturated fat are those which provide an apparent digestibility (AD) of at least 75$. Using this parameter of evaluation, it is possible using the compositions and methods of the present invention to obtain at least 90~
AD and through the use of preferred embodiments up to 99~ AD.
The exceptional high AD and energetic (Energy Density) content, per weight and per volume, are obtained because of the extremely high absorption rates that are possible because of the particular compositions devised by the applicant.
~S
f 3 _ 11_ ~~'':,!~rt?
DETAILED DESCRIPTION OF THE INVENTION
The amino acid composition of the invention is based on the use of crystalline amino acids in specific relative amounts which provide an net nitrogen utilization (NNU) of at least 75~. For example, if a particular subject who is fed which an amino acid formula has a nitrogen intake of 100.0 g. and a total nitrogen output of 100.0 g., the NNU
of the formula is 100'x. If the subject's nitrogen intake is 100 and the output is 128, then the NNU of the formula is 72$.
Using this parameter of evaluation, it is possible using the compositions and methods of the present invention to obtain at least 90~ NNU and through the use of preferred embodiments up to 100$ NNU.
],$ The exceptionally high NNU are believed to be obtained because of the extremely high absorption rates that are possible because of the particular compositions devised by the applicant.
The amino acid composition of the invention 20 comprise those having the following proportions of amino acids in grams per 10 grams of composition:
(a) from 1.217 to 1.647 isoleucine;
(b) from 1.827 to 2.735 leucine;
(c) from 1.260 to 2.359 lysine;
2S (d) from 0.232 to 0.778 methionine;
(e) from 0.843 to 1.314 phenylalanine;
(f) from 0.970 to 1.287 threonine;
(g) from 0.208 to 0.467 tryptophan; and (h) from 1.260 to 1.900 valine.
-12 - ~i~~~s?~
(I) isoleucine 1.217 - 1.530 leucine 1.827 - 2.735 lysine 1.260 - 2.078 methionine 0.232 - 0.778 phenylalanine 0.934 - 1.314 threonine 0.970 - 1.287 tryptophan 0.208 -0.467 valine 1.391 - 1.900 (II) isoleucine 1.251 1.647 leucine 1,846 - 2.130 lysine 2,023 - 2.359 methionine 0.490 - 0.778 phenylalanine 0.843 - 1.144 threonine 1.0S3 - 1.287 tryptophan 0.238 -0.401 valine 1,260 _ 1.426 (TII) ' isoleucine 1.289 -1.647 leucine 1.917 - 2.130 lysine 2.023 - 2.359 methionine 0.490 - 0.778 phenylalanine 0.843 - 1.144 threonine 1.053 - 1.271 tryptophan 0.238 -0.319 valine 1.342 - 1.426 3p r. ~, r;
~~~ ~;~ ~~3 _ 13, (IV) isoleucine 1.251 1.408 leucine 1.846 - 2.054 lysine 2.086 - 2.359 methionine 0.621 - 0,77g phenylalanine 0.969 - 1.144 threonine 1.106 - 1.287 tryptophan 0.293 - 0.401 valine 1.260 - 1.422 (V) isoleucine 1.372 - 1.530 leucine 1.827 - 2.539 lysine 1.550 - 2.078 methionine 0.490 - 0.708 phenylalanine 0.969 - 1.177 threonine 0.970 - 1.157 tryptophan 0.208 -0. 373 valine 1.422 - 1.600 zo (vz) isoleucine 1.2,17 1.530 leucine 1.952 - 2.735 lysine 1.260 - 1.999 methionine 0.232 - 0,778 phenylalanine 0.934 - 1.314 threonine 1:043 - 1.287 tryptophan 0.266 -0.467 valine 1.391 - 1.900 ~5 _ m_ cull) isoleucine 1.372 - 1.445 leucine 2.192 - 2.539 lysine 1.550 - 1.770 S methionine 0.490 - 0.642 phenylalanine 0.969 - 1.155 threonine 0,970 - 1.052 tryptophan 0.282 -0.319 valine 1.486 - 1.571 (VIIT) isoleucine 1.451 - 1.530 leucine 1.827 _ 1.846 lysine 2.020 - 2.078 methionine 0.490 - 0.642 phenylalanine 0.969 - 1.144 threonine 1.115 - 1.157 tryptophan 0.368 - 0.373 valine 1.422 - 1.483 (Ix) isoleucine 1.328 - 1.357 leucine 1.917 - 1.951 lysine 2.086 - 2.250 2S methionine 0.642 - 0.673 phenylalanine 0.969 - 1.144 threonine 1.196 - 1.287 tryptophan 0.333 - 0.340 valine 1.342 - 1.422 ~~~.~~,~
(X) isoleucine 1.366 - 1.408 leuc ine 1. 84 - 1 , 917 lysine 2.267 - 2.359 methionine 0.674 - 0.778 phenylalanine 0.969 - 1.144 threonine 1.106 - 1.157 tryptophan 0.311 - 0.333 valine 1.260 - 1.313 (XI) isoleucine 1.289 ~ 1.647 leucine 1.917 - 2.130 lysine 2.023 - 2.359 methionine 0.622 - 0.778 phenylalanine 0.843 - 0.988 threonine 1.053 - 1.271 tryptophan 0.238 -- 0.298 valine 1.342 - 1.426 (xzx) isoleucine 1,251 - 1.328 leucine 1..950 - 2.067 lysine 2.078 - 2.315 methionine 0.490 - 0.689 phenylalanine 0.969 - 1.144 threonine 1.106 - 1.152 tryptophan 0.282 - 0.401 valine 1.306 - 1.422 3rD
~~ ~ ~ ~ 'i f"?
,r ;: !.r ~.3 !.~
Preferred compositions include the following proportions by weight of the amino acids:
(XIII) isoleucine 1.217 ~ 1.477 leucine 2.281 - 2.735 lysine 1.332 - 1.999 methionine 0.232 - 0.608 phenylalanine 0.934 - 1.136 threonine 1.043 - 1.287 tryptophan 0.304 - 0.467 valine 1.391 - 1.900 (XIV) 15 isoleucine 1.408 - 1.530 leucine 1.952 - 2,077 lysine 1.260 - 1.521 methionine 0,674 - 0.778 phenylalanine 1.257 - 1.314 20 threonine 1.106 - 1.146 tryptophan 0.266 -0.373 valine 1.581 - 1.700 'fhe especially preferred compositions include those 2S having the follawing proportions by weight:
(z) (II) isoleucine 1.438 1.482 Ieucine 2.287 1.963 30 lysine 1.650 1.428 methionine 0.283 0.699 phenylalanine 0.943 1.288 threanine 1.226 1.111 tryptophan 0.448 0.368 35 valine 1.721 1.656 t' a ; ~' '~;3~~~,~(~
_ 17_ a ( IIT ) (_z~) isoleucine 1.310 1.341 leucine 2.053 1.922 lysine 2.189 2.144 methionine 0.621 0.651 phenylalanine 1.029 1.027 threonine 1.107 1.211 tryptophan 0.293 0.338 valine 1.390 1.358 (V) (VT) isoleucine 1.381 1.311 leucine 1.891 1.951 lysine 2.297 2.266 methionine 0.68?. 0.752 phenylalanine 1.029 0.959 threonine 1.113 1.119 tryptophan 0.318 0.256 valine 1.284 1.376 (VIT) (VIIT) isoleucine 1.443 1.484 leucine 2.226 1.832 lysine 1.760 2.064 methionine 0.556 0.580 phenylalanine 1.100 1.p67 threonine 1.041 1.136 tryptophan 0.317 0.371 valine 1.553 1.461 The compositions of the invention may be utilized in the prevention and/or treatment of nutritional and/or metabolic disorders in healthy or sick people as a supplement and/or substitute to the regular diet. Tn particular, the . °.s 18 -.
compositions may be used for nutrition in conditions such as:
Protein--Calorie Malnutrition (PCM), cystic fibrosis, anorexia nervosa, immunodeficiency caused by malnutrition, treatment and prevention of malnutrition in AIDS patients, gout, renal failure, hepatic disorders, burn therapy, hypovitaminosis, hypercholesterolemia, hypoalbuminemia, alcoholism, hemophilia, tuberculosis, pre and post-surgery, hospitalized patients° diet, neurologic disorders patients, pre-menstrual edema and nutritional losses of menstruation, neoplasms, chronic diseases, illicit-drug rehabilitation, malabsorption, food allergy, peptic ulcer, diarrhea, gastrointestinal disorders, short bowel syndrome, hyperlipidemia, diabetes mellitus, gall bladder disorders, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly, nutrition in convalesent patients and nutrition during athlete's training.
The amino acid composition of tk-xe invention is of special utility in providing nutrition to patients suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC). The composition of. the invention may also be used in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor, marasmus and the like.
If desired, the amino acid composition of the invention may be used to the treatment and prevention of obesity, or as a supplement/replacement composition for use in providing and/or enhancing a basic source of nutrition for infants, children and adults. It is of particular utility in geriatric patients.
In the treatment and prevention of obesity, as well as in the maintenance of optimal body weight it may be desirable to include decreasing amounts of a source of calories to avoid hypoglycemia. For example, in the first day may include 2000 Kcal and this may be decreased by 200 Kcal for each day to a minimum of 800 K/cal/day. For physician supervised diets in an institution, a diet without °
19 °
any substantial source of calories may be used after gradually decreasing amounts of a source of calories are used. The calorie content may be reduced to less than 100 Kcal may be used, if necessary.
It is possible to substitute cysteine for part of the methionine component; and to substitute tyrosine for part og the phenylalanine component.
The amino acid compositions of the invention have particular use in pregnancy because the proper requirement of protein is supplied without increasing Blood Urea Nitrogen (BUN) or other nitrogen metabolic residuals; in addition, its use prevents nutritional and metabolic disorders and their consequences during pregnancy and lactation.
The amount of the amino acid composition to be used in each particular condition may generally be determined by titration of individual patients to obtain the desired nutritional response or by use of from 0.5 g to 5.0 g/kg of ideal body weight/per day of the amino acid composition of the invention, and preferably .from 1.0 g to 2.0 g/kg of body ideal weight/per day given orally or parenteraly. Certain of the compositions of the invention may be used intravenously, however, the preferred route of administration is orally via normal feeding or by a stomach tube because absorption is higher and the nosocomial infections associated with intravenous feeding may be avoided. The amino acid composition may be administered dry as a powder, in capsules or tablets, as a.
solution or dispersion in a suitable liquid, or in a semi-solid medium. The ideal weight is determined according to the method set forth in Example I.
0 The mineral-free, protein-free carbohydrate and highly polyunsaturated vegetable fat composition of the invention is based on the use of specific mineral-free, protein-free carbohydrates) and mineral-free, protein-free highly polyunsaturated vegetable fat(s), which will provide 5 an exceptional high AD, providing an apparent digestibility _ 20 _ of at least 75$, preferably 80~ and most preferably 95~.
The use of mineral-free, protein-free carbohydrates) is in the form of the alcohol of glucose, namely sorbitol (glucitol), and/or disaccharides, namely sucrose, and/or maltose. Sorbitol has a therapeutic value as a replacement carbohydrate in the diet of diabetics; sucrose is perhaps the most common and best known disaccharide in the diet, and maltose, which has a relative sweetness value of 40, can replace all or part of the sucrose contents to decrease the sweetness of the composition, and make it more palatable.
The use of mineral-free, protein-free vegetable fat is in the form of vegetable oils with a polyunsaturated/
saturated ratio (P/S ratio) of a least 4.6, preferably 7.0 and most preferably 8.2. The use of vegetable oils with a very high (more than 4.5 P/S ratio), namely safflower oil (8.2 P/S ratio, and/or sunflower oil (7.0 P/S ratio), and/or corn oil (4.6 P/S ratio)(5), is because has been demonstrated convincingly that diets enriched in EFA such as linoleic acid (highly present in safflower oil and/or sunflower oil and/or 24 corn oil) and reduced in saturated fatty acids do lower significantly LDL and VLDL cholesterol in man at both 30 and ~0 in $ of fat levels.
It is to be understood that one or more of the mineral-free, protein-free carbohydrates may be used with one or more of the highly polyunsaturated vegetable fats to provide a composition having the desired flavor and calorie content. Distilled water or any other suitable mineral-free diluent may be added, as desired.
The exceptional high, AD of the nutritional composition of the invention, providing a carbohydra a and vegetable fat composition with an exceptional high apparent digestibility (AD), providing at least 75~, preferably 80~
and most preferably 95~ AD, and an exceptional high'Energy density, providing in the liquid form composition at least 4Kca1/cc (3Kca1/g), preferably ~.~ Kcal/cc (3.4 Kcal/g), and t ~~ ~~;.=~l~
most preferably 4.7 Kcal/cc (3.7 Kcal/g), and an exceptional vegetable fat P/S ratio, providing a P/S of at least 4.s, preferably 7.0 and most preferably 8.2 are obtained by the use of the applicants' compositions.
F'nrm" 1 ~ T
Maltose 70-95 wt.
Safflower Oil 5-30 wt.
TOTAL 100.0 wt.
ZO Fnrm"'1o TT
Maltose 70-95 wt.
Safflower Oil and 5-30 wt. $
Sunflower Oil TOTAL 100.0 wt.
15 (The safflawer oil and sunflower oil may comprise from 1-99 wt. ~ to 99-1 wt. ~ of the total oil content) Formula III
Sorbitol 70-95 wt. ~
Safflower Oil 5-30 wt. ~
as TOTAL 100.0 wt.
Formula IV
Sorbitol 70-95 wt. ~
Safflower Oil and 5-30 wt. ~
2S Sunflower oil TOTAL 100.0 wt. ~
(The safflower oil and sunflower oil may comprise from 1-99 wt. $ to 99-1 wt. ~ of the total oil content) 30 Formula V
Sucrose and 70-95 wt. g Maltose Corn Oil 5-30 wt. ~
TOTAL 100.0 wt. ~
9 ,. ~ ,.? (?
_ 22 Sucrose and 70-95 wt. $
Maltose Sunflower Oil 5-30 wt. $
TOTAL 100.0 wt. ~
Formula VII
Sorbitol and 70-95 wt. $
Maltose 1~ Safflower Oil 5-30 wt. $
TOTAL 100.0 wt' $
Formula VITI
Sorbitol and 70-95 wt. $
Maltose Safflower Oil and 5-30 wt. $
Sunflower Oil TOTAL 100.0 wt. $
(The safflower oil and sunflower oil may comprise from 1-99 wt' $ to 99-1 wt. $ of the total oil content) Formula IX
Sucrose, 70-95 wt.
Maltose and Sorbitol Safflower Oil, 5-30 wt. $
Sunflower oil and Corn Oil TOTAL 100.0 wt. $
(The safflower oil, sunflower oil and corn oil may comprise from Z-99 wt. $ to 99-1 wt, $ of the total oil content) Formula X
Sucrose, 70-95 wt. $
Maltose and Sorbitol Corn Oil 5-30 wt. $
TOTAL 100.0 wt. $
Vitamins are organic micronutrients essential for normal growth and maintenance of life. Vitamins cannot be synthesized by the organism and for these reasons they have to be supplied from an exogenous source. Vitamins provide the only source of certain coenzymes necessary for metabolism, the biochemical process that supports life. Vitamins are classified as fat-soluble and water-soluble. Fat-soluble vitamins, namely A, D, E, and K are stored in body fat and may therefore accumulate in quantities that can be toxic.
i0 The B vitamins and vitamin C are water-soluble and most of them are rapidly excreted in the urine and thus rarely cause toxicity. Vitamin C and B12 tend to be stored in the body.
Effects of vitamins) deficiency, as well, as, toxicity (excessive intake) are dangerous to health, and must i5 be avoided.
The inorganic nutritional minerals and trace elements present in food are essential for health. Some such as calcium, phosphorus, and potassium, occur in the body in concentrations 0.005. Others termed "trace elements'° such 20 as iron, zinc, and iodine, occur in much smaller concentrations ( O.OOS$).
The inorganic elements have many functions such as electrolytes, components of the bones and teeth, components of the prosthetic group of enzymes, and others.
Effects of minerals) deficiency, as well as, toxicity (excessive intake) are dangerous for health and must be avoided.
The preferred group of vitamins and minerals are set forth below. It should be understood that ~rariations in 30 the preferred group may be made but the essence of the applicant's inventive use of vitamins and minerals in the administration of these nutritional elements is in the use of a specific ratio of vitamins and minerals to the total amount of specific amino acids administered to a particular patient 35 taking into consideration the interrelationship - 24~ -specific amino acid(s), vitamins) and mineral(s). This is to allow high NNU, as well as, to avoid hypo or hypervitaminnosis (deficiency or toxicity).
Sodium 13.00 - 23.00 mg Potassium 41.00 - 69.00 mg Magnesium 2.50 - 5.00 mg Calcium 27.00 - 45.00 mg Manganese 1.50 - 3.50 mcg Iron 37.00 -100.00 mcg Cobalt 1.00 - 2.00 mcg Copper 35.00 - 65.00 mcg Zinc 0.16 - 0.28 mg Nickel 0.75 - 2.50 mcg Chromium 50.00 - 85.00 mcg I5 Molybdenum 0.70 - 5.00 mcg Vanadium 0.35 - 0.65 mcg Phosphorus 11.00 - 35.00 mg Chloride 30.00 - 50.00 mg Fluoride 13.00 - 22.00 mcg Iodine 4.00 - 8.00 mcg Selenium 2.00 - 4.50 mcg Bromine 0.07 - 0.13 mg Boron 4.00 - 8.00 mcg Silicon 22.00 - 40.00 mg Vitamin A 60.02 - 109.00mcg ' Vitamin D 37.00 - 63.00 ng Alpha- 0.78 - 1.30 ng Tocopherol Vitamin K 2.00 - 4.00 mcg Vitamin B1 10.00 - 20.00 mcg Vitamin B2 27.00 - 48.00 mcg Nicotinamide 0.13 - 0.23 mg Pantotenic Acid 0.18 - 0.30 mcg Vitamin B6 13.00 - 23.00 mcg Biotin 0.43 - 0.73 mcg fu ° 25 °
O
Fo1 is Ac id 3 . 50 - 6 . 50 mcg Vitamin B12 35.00 - 65.00 ng Vitamin C 3.00 - 6.50 mg The compositions of the invention may be given as dry as a powder, or as tablets, ar as a solution in water, or as a dispersion in a suitable liquid, or semi-solid medium.
The mineral--free, protein-free carbohydrate and highly polyunsaturated vegetable oil compositions of the 1~ invention may be utilized as a complement in the prevention and treatment of Protein--Calorie Malnutrition (PCM) or as a supplement and/or substitute of carbohydrate and/or fat of the regular diet. In particular, these compositions may be used for nutritional complement in conditions such as:
1~ Protein Calorie Malnutrition (PCM), cystic fibrosis, anorexia nervosa, immunodeficiency caused by malnutrition, tx'eatment and prevention of malnutrition in AIDS patients, hypercholesterolemia, gout, hepatic disorders, burn therapy, renal disorders, alcoholism rehabilitation, tuberculasis, pre and post surgery, hospitalized patients' diet, neurological disorders, cancer patients, chronic diseases, illicit-drug rehabilitatian, malabsorption, food allergy, diarrhea, diabetes mellitus, nutrition in infants, nutrition in adolescents, nutrition in adults, nutrition in elderly.
These compositions of the invention are of special utility in providing a nutritional complement to patients.
suffering from Acquired Immune Deficiency Syndrome (AIDS) or Aids Related Complex (ARC).
The composition of the invention may also be used as a complement in the treatment of Protein-Calorie Malnutrition (PCM), such as kwashiorkor or marasmus and the like.
If desired, the composition of the invention may be used as a supplement/replacement composition for use in 35 providing and/or enhancing a basic source of nutrition for ,_ ~~~,~.~,~'~t U
infants, children and adults. It is of particular utility in geriatric patients.
The amount of the composition to be used in each particular condition may generally be determinated in accordance of the energetic need of individual patients to obtain that desired nutritional response. The preferred route is the oral route, but a tube may be used for direct infusion into the alimentary tract.
When patients are treated with compositians i~ according to this invention, it is desirable to initially administer 10~ of the total calculated dose and to increase the dose by 10~ per day over a 10 day period. This is done to avoid gastrointestinal problems such as bloating and diarrhea.
The composition may be given as a solution in water, or as a dispersion in a suitable :Liquid, or semisolid medium.
It is to be understand that convention saurces of dietary fiber may be taken in combination with the compositions z0 of the invention, if desired. These sources include fruits, poyllium, bran, vegetables, etc.
is -z7-m E~L,AIriPLE 1 A comparative double-blind, triple cross-over study was carried out in sixty-six subjects, during a 114 day period, to examine subject's nitrogen balances to determine the net nitrogen utilization (NNU) of consumed protein or amino acid formula, during Diets A, B and C.
A group of 6F patients were fed with a Metabolism Equalizing and Stabilizing Diet (MESD) for a 30 day period.
The composition of the formula in grams per 10 grams of amino acids wasp Table Ile 1.438 Leu 2.
1~ Lys 1.650 Met 0.
Phe 0.
Thr 1.226 Trp 0.448 2o val 1.721 Sixty-six healthy subjects were fed with MESD, during the 30 day period, in the preliminary phase of this study, with the purpose of equalizing and stabilizing their 25 protein and energy metabolisms, thus avoiding different metabolism degrees, which could affect their nitrogen balances.
To avoid common errors in energy intake, which also could affect nitrogen balance, MESD supplied a constant ~~ energy intake per subject equivalent to 50 Kcal/Kg/day, during the 30 day period.
To avoid common errors in nitrogen intake, which could affect the nitrogen balance, the carbohydrate and fat of MESD were selected from the essentially protein-free 35 foods of Table IA.
Table IA, Food Com position x 100 Energy g Fruits: Protein (Calories) Apricot 0.8 57 Pineapple 0.4 52 Peach 0.8 52 Strawberry 0.8 36 Pondapple 0.4 52 Tangerine 0.7 43 Mango 0.5 5g Apple 0.3 58 Muskmelon 0.5 25 Orange 0.7 50 Loquat 0.2 44 ~5 Papaya 0.5 32 Pear 0.3 56 Watermelon 0.5 22 Vegetables:
Celery 0.8 19 Eggplant 1.0 27 Waxgourd 0.5 14 Chayote 0.9 31 Lettuce 1.0 13 25 Cucumber 0.7 15 Ripe tomato 0.8 21 Sweet Cassava 1.0 132 Carrot 0.8 41 Sucrose 0.0 384 Corn oil 0.0 384 Maltose 0:0 384 Sorbitol 0.0 384 35 Sufflower Oil 0.0 884 l ~ .1 _ 29 _ Sunflower Oil 0.0 884 Corn Oil 0.0 884 To avoid unnecessary nitrogen loss, and to stabilize subjects' protein metabolisms, MESD also supplied a decreasing amount of protein from the amino acid formula (Table I) during the 30 day period as follows:
(a) 1st and 2nd day: protein intake of 0.80 g/Kg/day;
(b) 3rd and 4th day: protein intake of 0.75 g/Kg/day;
(c) 5th and 6th day: protein intake of 0.70 g/Kg/day;
(d) 7th and 8th day: protein intake of 0.65 g/Kg/day;
(e) 9th and 10th day: protein intake of 0.60 g/K g/day;
(f) 11th and 12th day: protein intake of 0.55 g/Kg/day;
(g) 13th and 14th day: protein intake of 0.50 g/Kg/day;
15 (h) 15th and 16th day: protein intake of 0.45 g/Kg/day;
and (i) from the 17th to the 30th day: protein intake of 0.40 g/Kg/day.
The protein requirement was calculated for each 2p subject in accordance with each subjects ideal weight. The amino acid formula was fed .in three divided doses at 8:00 a.m.; 2:00 p.m. and 8:00 p.m. ~, vitamin-mineral supplement according to Example 4 was also fed to each patient.
After the MESD conclusion, at the beginning of the 2s main phase, the sixty-six healthy subjects were randomly divided into three matched groups, according to sex and number, and named Groups 1, 2 and 3. In accordance with the diet sequence (Table II), the main phase of this study, was conducted during three consecutive 28 day periods, with the purpose of examining subjects° nitrogen balances, in order to evaluate their net nitrogen utilization (NNU) of consumed protein and amino acid formulas, during the periods of Diets A, B and C .
Table II
Sequence of the Diets by Grou Group 1 MESD--_________A___________g___________~
Group 2 MESD-_-________B ___________C___________A
Group 3 MESD_-_________C___________A__________ -B
To achieve this purpose, Groups 1, 2 arid 3, each comprised of twenty_two healthy subjects, were fed with diets A, B, and C, following the obligatory sequence (Table II) and schedule (Table III).
T9hlo TTT
Sequence of Diets by Group and Period Group Group 2 Group First Period (28 days) Diet A B C
Second Period (28 days) DietB C A
Third Period (28 days) Diet C A B
Diets A, B, and C consisted of an identical composition of protein, carbohydrate, fat, vitamins and min erals, but of a different protein source. The diets had the following characteristics:
DTET "A" provided to the subject, a protein intake of 0.4 g/Kg/day, equivalent to 69 mg/Kg/day of nitrogen, from the amino acid formula of Table I and an energy intake of 50 Kcal/Kg/day, from protein-free carbohydrate and fat from Table IA.
DIET "B" provided to the subject a protein intake of 0..4 g/Kg/day, equivalent to s4 mg/Kg/day of nitrogen, from hen whole egg amino acid formula (Table IV) and an energy intake of 50 Kcal/Kg/day, from protein-free carbohydrate and fat from Table IA.
:~ ~ r~ ~.~ o - 31.
Table IV
Amino Acid Composition of Hen Whole Egg*
(Grams of amino acids in 1008 of protein) Arg 1.04 S Asp 7. 75 Cys-Cys 2.58 Glu 13.69 Gly 3. 91 His 2.65 Ile 7.35 Leu 9. 73 Lys 7.08 Met 3.46 Phe 6.39 1S Pro 4.69 Ser 9.29 Thr 5.50 Trp 1.82 Tyr 4.76 val a.21 Corn Oil and sucrose were added to the previous composition, in the following amounts, to provide an energy content in the form of fat and carbohydrate content that approximates that 2S of dried hen whole egg.*
Corn oil 90.00 g Sucrose 7.00 g The achievement of the equalization among formula compositions was obtained by adding to both Diet A - formula of Table I, and Diet B - hen whole egg amino acids formula of Table IV the amount of 0.9 g of fat (corn oil), plus 0.07 g *Basec3 on the data presented in Orr, M.D., and Watt; B.K., ~~~lno Acid Content of Foods" U.S. Dept. Agr., 1957.
;. ~ .,: c i a of carbohydrate (sucrose) per each gram of protein Content of the formulas, achieving an equivalent composition of protein, fat and carbohydrate as contained in the Diet C - dried hen whole egg as follows:
Dried Hen YJhole Egg Composition in 100g.*
Protein 47.0 g Fat 41.2 g Carbohydrate 3.4 g Kcal. 584 DIET "C°° provided to the subject a protein intake of 0.4 g/Kg/day, equivalent to 64 mg/Kg/day of nitrogen, from dried hen whole egg and an energy intake of 50 Kcal/Kg/day from protein-free carbohydrate and fat (Table IA).
To avoid common errors in determining nitrogen intake, which could affect the nitrogen balance, the carbohydrate and fat of Diets A, B and C were substantially protean-free (Table IA).
To avoid common errors in determining energy intake, which could also affect nitrogen balance, Diets A, B
and C supplied a constant energy intake per subject equivalent to SO Kcal/Kg/day, during each 28 day period.
To avoid over-estimating nitrogen intake, caused by unconsumed daily protein or amino acids formula during each 28 day period, all sixty-six subjects were fed three times per day (8:0o a.m.; 2:00 p.m.; and 8:00 p.m.) achieving the total consumption of their allotted formula.
To avoid error in determining energy intake, which could affect nitrogen balance, formulas given during Diets A, B and C had an equivalent composition of protein, fat and carbohydrate, which provided the same energy intake.
The identification by the subject of his/her formula by its flavor which could affect the double-blind characteristic of the sutdy was prevented by adding to the * INCAP-ICNND Composition of Foods, 1961.
~~'~~=~ J
- 33 °
formulas of Diets A, B and C a common fru it shake. To avoid errors in energy intake, this fruit shake, by itself, provided the same energy intake. The fruit for the shake was changed almost daily, and was chosen from Table V.
Table ~1 Food Composition x 100 Energy g Fruits Protein (Calories) Pineapple 0.4 52 Pondapple 0.4 52 Papaya 0.5 32 Watermelon 0.5 22 To avoid a nitrogen over-intake per g/kg/day, which could affect the nitrogen balance, the subject's protein requirement was based on his/her ideal weight. A daily vitamin-mineral supplement according to Example 4 was given to all subjects.
Determining Weight The subject's weight (in kg) was determined, in the early morning after subject's urination and evacuation, and before breakfast. The result was rounded off to the nearest 0.100 kg (range 50 g).
Determining Ideal Weight The subject's ideal weight (in kg) was obtained by subtracting factor 100 from the subject's height (in cm), then multiplying the result by either factor 0.9 (male) or 0.8 (female), in accordance with subject's sex. The result was rounded off to the nearest 0.500 kg (range 250 g). The following formula was applied:
male's ideal weight = ((Height - 100) x 0.9] kg female°s ideal weight = [(Height - 100 x 0.8] kg iJ
_ ~4 _ Determining Nitrogen Balance To determine the subject's nitrogen balance, the following formula was used:
B = I - ( U + F + S ) where:
B = N balance;
I = N intake;
U = N loss in urine;
F = N loss in feces; and S = N dermal losses.
The nitrogen balance represents the difference between N intake (T), and N output (U + F + S), the difference being either positive (N retention), as in active growth, negative (N loss), or zero (N equilibrium).
Determining Nitrogen zntake To determine the subject's nitrogen intake (I), the following formula is used:
Diet protein amount = Dietary nitrogen x 6.25 where use of factor 6.25, implies that the average protein contains 16~ nitrogen.
Determining Nitrogen Loss The urine (U) and feces (F), of each subject are collected throughout each 24--hour day of each consecutive 28 day period, to determine the nitrogen lass by micro-.Kjeldahl techniques.
To determine the subject's nitrogen dermal and minor route losses (S), a constant factor was used:
30 (S) = 5 mg x subject weight (kg) x day _35 _ ~~~~xyt~ot Determining Nitrogen Balance This calculation was made by taking into consideration the subject's real weight. To avoid any misinterpretation in the subject's daily nitrogen balance, which is not usually constant, the subject's diet nitrogen intake (I) per period, and the diet nitrogen output (U + F + S) per period, were obtained by adding up the subject daily nitrogen intake and output amounts, during the diet period.
The subject's nitrogen balance was obtained by the difference between the dietary nitrogen intake (I) per period, and the dietary nitrogen output (U + F + S) per period.
Determining Mean Nitrogen Loss The mean of each subject's nitrogen loss, per period, was obtained by adding up each subject nitrogen loss amount during a diet period, and dividing the result by the total number of subjects.
Determining Mean Protein Loss The mean protein loss per each subject per period, is obtained by multiplying the mean nitrogen loss per period by factor 6.25, All calculations were in accordance with the following formula:
PROTEIN = (N g) x 6.25 where it is assumed that the N content of the mixed proteins of the body is 16~. Thus 1 g of N excreted represent a loss from the body of 6.25 g of mixed proteins.
Determining Mean Tissue Loss The mean tissue loss per subject per period, is obtained by multiplying the mean protein loss per period by factor 5. All calculations are in accordance with the following formula:
LEAN TISSUE = (N g) x 6.25 x 5 ,36 ~ ~~«~H ,.
To illustrate: the N content of the mixed proteins of the body is 16~. Thus 1 g of N excreted represents a loss from the body of 6.25 g of mixed proteins. Intracellular protein exists in approximately a 20 to 25~ aqueous solution in the lean tissue of the body (the fat-free, connective tissue-free, and bane-free "wet" tissue).
P.ssuming that 1 g protein is associated with 5 g of hydrated lean tissue, then 1 g of excreted nitrogen represents a loss of 1 x 6.25 x 5 = 31.25 g of lean tissue.
Determining Mean NitrogenLoss Per Kilo Per Period The subjects' mean nitrogen loss per sub ect j per kg per period, is obtained by dividing the subjects' mean nitrogen loss per period by the mean ideal weight.
is Determining Range of Mean Nitrogen Loss Per Kilo Per Period The subjects' range of mean nitrogen loss per subject per kg per period, is obtained by calculating the difference between the highest and lowest subject°s nitrogen loss per period.
zs ~o 37 _ RESULTS OF THE STUDY
GROUP "1" NITROGEN BALANCE RESULTS BY DIET
Diet A B C
Group 1 equilibrium negative negative The following are the nitrogen balance results obtained from Group °'1°' comprised of twenty-two subjects, with a mean ideal weight of 55 kg, during each 28 day diet period:
DURING DIET "A"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM*
Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
i5 Mean Lean Tissue Loss per subject per period: NONE
DURING DIET "B"
Period: 28 days Subjects: 22 NITRQGEN ubject per period: NEGATIVE*
BALANCE
per s MeanNitrogen Loss subject per period: 28,56 g per Mean Nitrogen Loss kg per period: 519 mg per Mean Protein Lass subject per period: 178.50 g per Mean Lean Tissue Lossper subject per period:892.50 g ~S DURING DIET "Cn Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: NEGATIVE*
Mean Nitrogen Loss per subject per period: 32.78 g Mean Nitrogen Loss per kg per period: 596 mg Mean Protein loss per subject per period: 2p~~,87 g Mean Lean Tissue Loss per subject per priori: 1,02.37 g *found in all twenty two subjects.
3 8 ~ ~ ',-~~~ ~ ;i' .;
GROUP "2'° NTTROGEN BALANCE BY DTET
Diet B C A
Group 2 negative negative equilibrium The following are the nitrogen balance results obtained from Group "2" comprises of twenty-two subjects, with mean ideal weight of 53.5 kg, during each 28 day diet period:
DURING DIET "B°' Period: 28 days Subjects: 22 NITROGEN ubject per period: NEGATIVE*
BALANCE
per s Mean Nitrogen Loss subject per period: 26.51 g per Mean Nitrogen Lass kg per period: 495 mg per Mean Protein Loss subject per period: 165.68 g per Mean Lean Tissue Lossper subject per period:828.93 g DURTNG DIET "C"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: NEGATIVE*
ZO Mean Nitrogen Loss per subject per period: 30.47 g Mean Nitrogen Loss per kg per period: 569 mg Mean Protein Loss per subject per period: 190.43 Mean Lean Tissue Loss per subject per periad: 952.18 g DURING DIET "A"
Period: 28 days ~ Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM*
Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per priod: NONE
*found in all twenty-two subjects.
3 9 - ~ ~ 'a ,!~ ~ ;P
a~ ~, .~ :~
GROUP "3" NITROGEN BALANCE BY' DIET
Diet C A
B
Group 3 negative equilibrium negative S The following are the nitrogen balance results obtained from Group "3" comprises of twentydtwo subjects, with a mean ideal weight of 53 kg, during each 28 day diet period:
DURING DIET °°C"
Period: 28 days Subjects:
NITROGEN ubject ger period:NEGATIVE*
BALANCE
per s Mean Nitrogen Loss subject period: 30.43 g per Mean Nitrogen Loss kg per period: 574 mg per Mean Protein Loss subject per period:190.18 g per 1S Mean Lean Tissue Lossper subject per iod: 950.93 g per DURING DIET '°A"
Period: 28 days Subjects: 22 NITROGEN BALANCE per subject per period: EQUILIBRIUM
20 Mean Nitrogen Loss per subject per period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per period: NONE
DURING DIET "B"
2S Period: 28 days Subjects: 22 NITROGEN BALANCE per ubject per period: NEGATIVE *
s Mean Nitrogen Loss per subject per period: 26.57 g Mean Nitrogen Loss per kg per period: 501 mg Mean Protein Lass per subject per period: 166.06 g 30 Mean Lean Tissue Lossper subject per period:830.31 g *found in all twenty-two subjects.
NITROGEN BALANCE BY GROUP AND DIET
Diet A B C
Group 1 equilibrium negative negative Group 2 equilibrium negative negative Group 3 equilibrium negative negative The following are the nitrogen balance results obtained from the sixty-six subjects belonging to Groups 1, 2, and 3, with a mean ideal weight of 54 kg, during each consecutives 28 day diet period:
1~ DURING DIET "A"
Period: 28 days Subjects: 66 NITROGEN BALANCE per subject per period: EQUILIBRIUM
Mean Nitrogen Loss per subject per, period: NONE
Mean Protein Loss per subject per period: NONE
Mean Lean Tissue Loss per subject per period: NONE
DURTNG DIET "B"
Period:28 days Subjects: 66 NITROGEN NCE per ubject per period: NE GATIVE*
BALA s Mean NitrogenLoss subject per period: 27.21g per Mean NitrogenLoss kg per period: 504 m per 9 Range o.f NitrogenLoss per kg per period: 27 mg Mean Mean ProteinLoss subject per period: 170.06g per Mean Lean sue Lossper subject per period: 850.31g Tis DURING DIET "C"
Period:28 days Subject: 66 NTTROGEN NCE per subject per period: NEGATIVE
BALA
Mean NitrogenLoss per subject per period: 31.22 g Mean NitrogenLoss per kg per period: 578 mg Range of MeanNitrogen Loss per kg per period: 28 mg Mean ProteinLoss per subject per period: 195.12g Mean Lean sue Loss per subject per period: 975.62g Tis *found in all sixty-six subjects.
_ 41_. _ 2~:3~ , .~ .;: ~~ ae ~
a The sixty-six subjects have shown:
(a) the highest net nitrogen utilization (NNU) when receiving the formula of Table I, during Diet A periods, by achieving "equilibrium" in their nitrogen balances;
(b) a lower net nitrogen utilization (NNU) when receiving hen whole egg amino acids formula, during Diet B
periods, by obtaining negative nitrogen balances, with a mean nitrogen loss per subject equivalent to 504 mg/kg/period, which was 28$ less net nitrogen utilization (NNU) than when receiving the formula of Table I during Diet A; and (c) the lowest net nitrogen utilization (NNU) when receiving dried hen whole egg, during Diet C periods, by obtaining negative nitrogen balances, with a mean nitrogen loss per subject equivalent to 578 mg/kg/period, which was 32~ less apparent protein digestibility than when receiving the formula of Table I during Diet A periods.
The hen whole egg protein has been considered to be the protein food with the highest net nitrogen utilization (NNU). The formula of Table T has shown the highest net ~0 nitrogen utilization (NNU)~ by all sixty-six subjects, than both hen whole egg and hen whole egg amino acid formula. It can be concluded that the formula of Table I has a higher apparent protein digestibility than hen whole egg protein.
Claims (20)
1. A nutritional composition comprising a combination of the following:
(a) isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine in amounts relative to one another which will provide a Net Nitrogen Utilization (NNU) at least 80%;
(b) a carbohydrate selected from the group consisting of sucrose, maltose and sorbitol, and a highly polyunsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil; and (c) for each gram of amino acid, an amount of vitamins which is equivalent to the following:
Vitamin A 60.02 - 109.0 mcg Vitamin D 37.0 - 63.0 mcg Alpha-tocopherol 0.78 - 1.30 mg Vitamin K 2.0 - 4.0 mcg Vitamin B1 10.0 - 20.0 mcg Vitamin B2 27.0 - 48.0 mcg Nicotinamide 0.13 - 0.23 mg Pantothenic Acid 0.18 - 0.30 mcg Vitamin B6 13.0 - 23.0 mcg Biotin 0.43 - 0.73 mcg Folic Acid 3.5 - 6.5 mcg Vitamin B12 35.0 - 65.0 ng Vitamin C 3.5 - 6.5 mg
(a) isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine in amounts relative to one another which will provide a Net Nitrogen Utilization (NNU) at least 80%;
(b) a carbohydrate selected from the group consisting of sucrose, maltose and sorbitol, and a highly polyunsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil; and (c) for each gram of amino acid, an amount of vitamins which is equivalent to the following:
Vitamin A 60.02 - 109.0 mcg Vitamin D 37.0 - 63.0 mcg Alpha-tocopherol 0.78 - 1.30 mg Vitamin K 2.0 - 4.0 mcg Vitamin B1 10.0 - 20.0 mcg Vitamin B2 27.0 - 48.0 mcg Nicotinamide 0.13 - 0.23 mg Pantothenic Acid 0.18 - 0.30 mcg Vitamin B6 13.0 - 23.0 mcg Biotin 0.43 - 0.73 mcg Folic Acid 3.5 - 6.5 mcg Vitamin B12 35.0 - 65.0 ng Vitamin C 3.5 - 6.5 mg
2. A nutritional composition as defined in claim 1, which includes the following minerals in amount per gram of amino acid:
Sodium 13.00 - 23.00 mg Potassium 41.00 - 69.00 mg Magnesium 2.50 - 5.00 mg Calcium 27.00 - 45.00 mg Manganese 1.50 - 3.50 mcg Iron 37.00 - 100.00 mcg Cobalt 1.00 - 2.00 mcg Copper 35.00 - 65.00 mcg Zinc 0.16 - 0.28 mg Nickel 0.75 - 2.50 mcg Chromium 50.00 - 85.00 mcg Molybdenum 0.70 - 5.00 mcg Vanodium 0.35 - 0.65 mcg Phosphorous 11.00 - 35.00 mg Chloride 30.00 - 50.00 mg Fluoride 13.00 - 22.00 mcg Iodine 4.00 - 8.00 mcg Bromine 0.07 - 0.13 mg Boron 4.00 - 8.00 mcg Silicon 22.00 - 40.00 mg
Sodium 13.00 - 23.00 mg Potassium 41.00 - 69.00 mg Magnesium 2.50 - 5.00 mg Calcium 27.00 - 45.00 mg Manganese 1.50 - 3.50 mcg Iron 37.00 - 100.00 mcg Cobalt 1.00 - 2.00 mcg Copper 35.00 - 65.00 mcg Zinc 0.16 - 0.28 mg Nickel 0.75 - 2.50 mcg Chromium 50.00 - 85.00 mcg Molybdenum 0.70 - 5.00 mcg Vanodium 0.35 - 0.65 mcg Phosphorous 11.00 - 35.00 mg Chloride 30.00 - 50.00 mg Fluoride 13.00 - 22.00 mcg Iodine 4.00 - 8.00 mcg Bromine 0.07 - 0.13 mg Boron 4.00 - 8.00 mcg Silicon 22.00 - 40.00 mg
3. A nutritional composition as defined in claim 1 wherein in the Net Nitrogen Utilization is at least 90%.
4. A nutritional composition as defined in claim 1 which comprises in grams per 10 grams of composition:
isoleucine~~ 1.217 - 1.477 leucine~~ 2.281 - 2.735 lysine~~~ 1.332 - 1.999 methionine~~ 0.232 - 0.608 phenylalanine~~ 0.934 - 1.136 threonine~~ 1.043 - 1.287 tryptophan~ 0.304 - 0.467 valine~~ 1.391 - 1.900
isoleucine~~ 1.217 - 1.477 leucine~~ 2.281 - 2.735 lysine~~~ 1.332 - 1.999 methionine~~ 0.232 - 0.608 phenylalanine~~ 0.934 - 1.136 threonine~~ 1.043 - 1.287 tryptophan~ 0.304 - 0.467 valine~~ 1.391 - 1.900
5. A nutritional composition as defined in claim 1 which comprises in grams per 10 grams of composition:
isoleucine~ 1.408 - 1.530 leucine~ 1.952 - 2.077 lysine~~ 1.260 - 1.521 methionine~ 0.674 - 0.778 phenylalanine~ 1.257 - 1.314 threonine~ 1.106 - 1.146 tryptophan~ 0.266 - 0.373 valine~~ 1.581 - 1.700
isoleucine~ 1.408 - 1.530 leucine~ 1.952 - 2.077 lysine~~ 1.260 - 1.521 methionine~ 0.674 - 0.778 phenylalanine~ 1.257 - 1.314 threonine~ 1.106 - 1.146 tryptophan~ 0.266 - 0.373 valine~~ 1.581 - 1.700
6. A nutritional composition as defined in claim 3 wherein the carbohydrate and highly polyunsaturated vegetable fat comprise from 12Kcal to 60Kcal per gram of amino acids.
7. A nutritional composition comprising a combination of the following essential amino acids:
isoleucine;
leucine;
lysine;
methionine;
phenylalanine;
threonine;
tryptophan; and valine, in amounts relative to one another which will provide a net nitrogen utilization of at least 80%.
isoleucine;
leucine;
lysine;
methionine;
phenylalanine;
threonine;
tryptophan; and valine, in amounts relative to one another which will provide a net nitrogen utilization of at least 80%.
8. A nutritional composition as defined in claim 6, which includes vitamins.
9. A nutritional composition as defined in claim 7, which includes minerals.
10. A nutritional composition as defined in claim 8, which also includes a source of carbohydrate and polyunsaturated vegetable fat.
11. A nutritional composition which comprises in grams per 10 grams of composition:
isoleucine~~ 1.217 - 1.477 leucine~~ 2.281 - 2.735 lysine~~~ 1.332 - 1.999 methionine~~ 0.232 - 0.608 phenylalanine~~ 0.934 - 1.136 threonine~~ 1.043 - 1.287 tryptophan~~ 0.304 - 0.467 valine~~~ 1.391 - 1.900
isoleucine~~ 1.217 - 1.477 leucine~~ 2.281 - 2.735 lysine~~~ 1.332 - 1.999 methionine~~ 0.232 - 0.608 phenylalanine~~ 0.934 - 1.136 threonine~~ 1.043 - 1.287 tryptophan~~ 0.304 - 0.467 valine~~~ 1.391 - 1.900
12. A nutritional composition which comprises in grams per 10 grams of composition:
isoleucine~~ 1.408 - 1.530 leucine~~ 1.952 - 2.077 lysine~~~ 1.260 - 1.521 methionine~~ 0.674 - 0.778 phenylalanine~~ 1.257 - 1.314 threonine~~ 1.106 - 1.146 tryptophan~~ 0.266 - 0.373 valine~~~ 1.581 - 1.700
isoleucine~~ 1.408 - 1.530 leucine~~ 1.952 - 2.077 lysine~~~ 1.260 - 1.521 methionine~~ 0.674 - 0.778 phenylalanine~~ 1.257 - 1.314 threonine~~ 1.106 - 1.146 tryptophan~~ 0.266 - 0.373 valine~~~ 1.581 - 1.700
13. A nutritional composition as defined in claim 11 or 12, which also includes vitamins.
14. A nutritional composition as defined in claim 11 or 12, which also includes a source of carbohydrate and a polyunsaturated vegetable fat.
15. A method of providing nutrition, which comprises orally administering to a patient a nutritionally effective amount of the composition of claim 1.
16. A method of providing nutrition which comprises orally administering to a patient a nutritionally effective amount of the composition of claim 9.
17. A method of providing nutrition to a patient which requires a restricted nitrogen intake, said method comprising a nutritionally effective amount of the composition of claim 1.
18. A method of providing nutrition to a patient who requires a low residue diet, said method comprising administering an effective amount of the composition of claim 1.
19. A method of providing nutrition to patients afflicted with acquired immune deficiency syndrome (AIDS) or acquired immune deficiency related complex (ARC), said method comprising administering an effective amount of the composition of claim 9.
20. A nutritional composition which comprises:
(a) from 70-95 wt. % of a protein-free carbohydrate selected from the group consisting of maltose, sucrose and sorbitol;
(b) from 5-30 wt. o of a protein-free highly unsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil.
(a) from 70-95 wt. % of a protein-free carbohydrate selected from the group consisting of maltose, sucrose and sorbitol;
(b) from 5-30 wt. o of a protein-free highly unsaturated vegetable fat selected from the group consisting of safflower oil, sunflower oil and corn oil.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/604,665 | 1990-10-26 | ||
US07/604,665 US5132113A (en) | 1990-10-26 | 1990-10-26 | Nutritional composition containing essential amino acids |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2054268A1 CA2054268A1 (en) | 1992-04-27 |
CA2054268C true CA2054268C (en) | 2002-12-10 |
Family
ID=24420507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002054268A Expired - Lifetime CA2054268C (en) | 1990-10-26 | 1991-10-25 | Nutritional composition |
Country Status (9)
Country | Link |
---|---|
US (1) | US5132113A (en) |
EP (1) | EP0482715B1 (en) |
JP (1) | JP3118289B2 (en) |
AT (1) | ATE142435T1 (en) |
CA (1) | CA2054268C (en) |
DE (1) | DE69122025T2 (en) |
DK (1) | DK0482715T3 (en) |
ES (1) | ES2094788T3 (en) |
GR (1) | GR3021978T3 (en) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242697A (en) * | 1990-10-26 | 1993-09-07 | Maurizio Luca | Method of preparing nutrified food products |
CA2078019C (en) * | 1991-09-13 | 2002-08-27 | Siegbert Heinrich Bissbort | Substance or composition and uses thereof |
JPH05163160A (en) * | 1991-12-13 | 1993-06-29 | Snow Brand Milk Prod Co Ltd | Nutrient preparation for prevention and treatment of infectious disease caused by immune depression |
US5629023A (en) * | 1991-12-31 | 1997-05-13 | Bland; Jeffrey S. | Medical food composition for metabolic detoxification |
FR2695317B1 (en) * | 1992-09-07 | 1995-03-10 | Monal Lab | Composition capable of stimulating the secretion of insulin intended for the treatment of non-insulin-dependent diabetes. |
DE69323731T2 (en) * | 1992-11-10 | 1999-07-22 | Otsuka Pharma Co Ltd | FOOD COMPOSITION |
US6764693B1 (en) * | 1992-12-11 | 2004-07-20 | Amaox, Ltd. | Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants |
CA2143420C (en) * | 1992-12-23 | 1999-01-19 | Phyllis J. B. Acosta | Medical foods for the nutritional support of infant/toddler metabolic diseases |
US5326569A (en) * | 1992-12-23 | 1994-07-05 | Abbott Laboratories | Medical foods for the nutritional support of child/adult metabolic diseases |
CN1124444A (en) * | 1993-05-26 | 1996-06-12 | 唐纳德·辛克莱·哈密尔顿 | Monohydrate dextrose or glucose composition |
US5855949A (en) * | 1994-01-10 | 1999-01-05 | Mclean; Linsey | Dietary system high in oil intake |
US5484623A (en) * | 1994-01-10 | 1996-01-16 | Mclean; Linsey | Dietary system high in oil intake for the treatment of obesity and for the lowering of saturated fats |
US5576287A (en) * | 1994-04-29 | 1996-11-19 | Wake Forest University | Method for treating acute renal disease and failure |
AU1515095A (en) * | 1994-12-13 | 1996-07-03 | Wm. Wrigley Jr. Company | Improved chewing gum containing salatrim |
US5589468A (en) * | 1995-01-13 | 1996-12-31 | Clintec Nutrition Co. | Method for providing nutrition to elderly patients |
US5605886A (en) * | 1995-01-31 | 1997-02-25 | Eli Lilly And Company | Anti-obesity proteins |
US5576001A (en) * | 1995-02-22 | 1996-11-19 | Abu-Shaaban; Medhat | Composition for the treatment of diarrhea, its use and its preparation |
JPH0995448A (en) * | 1995-09-29 | 1997-04-08 | Calpis Food Ind Co Ltd:The | Increase in biotin concentration in blood and biotin-containing beverage or food product |
MY115050A (en) * | 1995-10-16 | 2003-03-31 | Mead Johnson Nutrition Co | Diabetic nutritional product having controlled absorption of carbohydrate |
EP0896516A1 (en) * | 1996-04-12 | 1999-02-17 | Beth Israel Deaconess Medical Center, Inc. | Diabetic supplement bar |
US5866555A (en) * | 1997-03-12 | 1999-02-02 | Beth Israel Deaconess Medical Center | Diabetic supplement bar |
AU3784297A (en) * | 1996-08-12 | 1998-03-06 | Taisho Pharmaceutical Co., Ltd. | Zinc-containing composition |
EP0920321A1 (en) * | 1996-08-26 | 1999-06-09 | Oswald Wiss | Vitamine preparations for reducing oxygen consumption during physical efforts |
US5897891A (en) * | 1996-11-18 | 1999-04-27 | Godfrey; John C. | Flavorful zinc compositions for oral use incorporating copper |
US6413557B1 (en) | 1997-07-02 | 2002-07-02 | Kyung Ja Lee | Soy-containing nutrition supplement and process |
EP0891719A1 (en) * | 1997-07-14 | 1999-01-20 | N.V. Nutricia | Nutritional composition containing methionine |
US5817695A (en) * | 1997-12-24 | 1998-10-06 | Pellico; Michael A. | Nutritional product with high fat, low carbohydrate and amino acid imbalance |
AU771728B2 (en) * | 1998-12-28 | 2004-04-01 | Ya Global Investments, Lp | Cyanocobalamin (vitamin B12) treatment in allergic disease |
PT951842E (en) * | 1999-01-20 | 2003-04-30 | Nutricia Nv | ADAPTED BABY FOOD FORMULA |
CN1365279A (en) | 1999-07-28 | 2002-08-21 | 奥斯瓦尔德·维斯 | Preparations for reducing oxygen consumption during physical efforts |
US6827954B2 (en) * | 2000-04-12 | 2004-12-07 | Mid-America Commercialization Corporation | Tasty, convenient, nutritionally balanced food compositions |
US6846501B2 (en) | 2000-04-12 | 2005-01-25 | Mid-America Commercialization Corporation | Traditional snacks having balanced nutritional profiles |
US6726943B2 (en) | 2000-04-12 | 2004-04-27 | Mid-America Commercialization Corporation | Nutritionally balanced snack food compositions |
US6720015B2 (en) | 2000-04-12 | 2004-04-13 | Mid-America Commercialization Corporation | Ready-to-eat nutritionally balanced food compositions having superior taste systems |
US6716462B2 (en) | 2000-04-12 | 2004-04-06 | Mid-America Commercialization Corporation | Nutritionally balanced traditional snack foods |
US20020012733A1 (en) * | 2000-04-12 | 2002-01-31 | The Procter & Gamble Company | Compositions for reducing hypercholesterolemia and controlling of postprandial blood glucose and insulin levels |
US6899905B2 (en) | 2000-04-12 | 2005-05-31 | Mid-America Commercialization Corporation | Tasty, ready-to-eat, nutritionally balanced food compositions |
BR0001794A (en) * | 2000-05-15 | 2001-12-26 | Laboratorios Biosintetica Ltda | Application of phytosteroids (and their isomers), folic acid, cyanocobalamin and pyridoxine in dietary fibers (food) |
US7147859B2 (en) * | 2000-05-15 | 2006-12-12 | Laboratorios Biosintetica Ltda. | Application of phytosterols (and their isomers), folic acid, cyanocobalamin and pyridoxin in dietetic (alimentary) fibers |
WO2002013813A1 (en) * | 2000-08-11 | 2002-02-21 | The Lawson Health Research Institute | Compositions and methods for inhibiting islet dysfunction and autoimmune disorders |
US7696219B2 (en) | 2000-09-27 | 2010-04-13 | Everett Laboratories, Inc. | Method and composition for supplementation of nutritional deficiences in renal patients |
US6995166B1 (en) | 2000-09-27 | 2006-02-07 | Everett Laboratories, Inc. | Method and composition for supplementation of nutritional deficiencies in renal patients |
AU2001294245B2 (en) * | 2000-10-13 | 2006-09-21 | Chugai Seiyaku Kabushiki Kaisha | Compositions for improving lipid metabolism |
IT1319684B1 (en) * | 2000-12-12 | 2003-10-23 | Ursula Mariah Rothlin | PHYTOTHERAPIC FOOD PRODUCTS. |
DE10112925A1 (en) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | Use of sugar phosphates, sugar phosphate analogs, amino acids, amino acid analogs for modulating transaminases and / or the association p36 / malate dehydrogenase |
JP4300753B2 (en) * | 2001-05-31 | 2009-07-22 | 味の素株式会社 | Anemia suppressor and appetite suppressant |
ITTO20010580A1 (en) * | 2001-06-15 | 2002-12-15 | Professional Dietetics Srl | AMINO ACID BASED COMPOSITIONS FOR IMPROVING THE MYOCARDIC VENTRICULAR FUNCTION IN PATIENTS WITH DIABETES. |
US6660293B2 (en) | 2001-06-29 | 2003-12-09 | Everett Laboratories, Inc. | Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects |
US7560123B2 (en) | 2004-08-12 | 2009-07-14 | Everett Laboratories, Inc. | Compositions and methods for nutrition supplementation |
US8617617B2 (en) | 2002-12-10 | 2013-12-31 | Everett Laboratories, Inc. | Methods and kits for co-administration of nutritional supplements |
US6814983B2 (en) | 2002-12-10 | 2004-11-09 | Everett Laboratories, Inc. | Compositions and methods for nutrition supplementation |
US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
SI1670444T1 (en) * | 2003-10-03 | 2011-09-30 | Veijlen N V | Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases |
US20070184091A1 (en) | 2003-10-03 | 2007-08-09 | Gillessen Hubert Jean M F | Animal feed composition |
CN1313435C (en) * | 2003-10-27 | 2007-05-02 | 成都华高药业有限公司 | Novel method for extracting 4-hydroxy isoleucine product from trigonella |
US20050260302A1 (en) * | 2004-05-19 | 2005-11-24 | The Procter & Gamble Company | Nutritionally balanced traditional snack foods having a low glycemic response |
US8101587B2 (en) | 2004-08-12 | 2012-01-24 | Everett Laboratories, Inc. | Kits for nutrition supplementation |
EP1863472B1 (en) | 2005-03-21 | 2013-02-20 | Abbott Laboratories | Amino acid composition for improving glucose tolerance |
WO2006105112A2 (en) * | 2005-03-29 | 2006-10-05 | Ajinomoto Co., Inc. | Amino acid-containing composition for preventing or remedying in the skeletal muscle of aged people |
EP1890717A1 (en) * | 2005-05-26 | 2008-02-27 | Pediatrix Medical Group, Inc. | Nutrition formulations and methods of providing nutrition formulations |
EP1916913B1 (en) * | 2005-08-23 | 2010-11-10 | Dr. Armand Herberger | Protein composition for treating a physiologically caused, clinically normal increased need for protein |
DE112006002215A5 (en) * | 2005-08-23 | 2008-07-03 | Leweling, Hans, Dr. | Protein composition for the treatment of protein deficiency states |
WO2007049818A1 (en) * | 2005-10-27 | 2007-05-03 | Ajinomoto Co., Inc. | Anti-fatty liver, anti-obesity or hypolipidemic composition |
US7982066B2 (en) | 2005-12-09 | 2011-07-19 | Novalife, Inc. | High protein supplement |
WO2007084059A1 (en) * | 2006-01-20 | 2007-07-26 | Bjoerk Inger | A food composition comprising amino acids |
US9192593B2 (en) | 2006-08-30 | 2015-11-24 | Ajinomoto Co., Inc. | Amino-acid containing composition for inhibiting accumulation of fat |
TW200841826A (en) * | 2007-04-20 | 2008-11-01 | Bion Tech Inc | Composition comprising five kinds of process fruit/vegetable |
US9402412B2 (en) * | 2007-05-30 | 2016-08-02 | Nestec S.A. | Metabolic imprinting |
JP2011507548A (en) * | 2007-12-31 | 2011-03-10 | ネステク ソシエテ アノニム | Nutritionally appropriate menu for pediatric food |
AU2010292440B2 (en) * | 2009-09-14 | 2015-06-18 | Société des Produits Nestlé S.A. | Nutritional compositions for modulating inflammation including exogenous vitamin K2 |
JP2011121888A (en) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | Amino acid composition for inflammatory bowel disease |
JP2011144116A (en) * | 2010-01-12 | 2011-07-28 | En Otsuka Pharmaceutical Co Ltd | Additive for inflammatory bowel disease |
WO2011119023A1 (en) | 2010-03-26 | 2011-09-29 | N.V. Nutricia | Low protein infant formula with increased essential amino acids |
US10750771B2 (en) | 2011-06-23 | 2020-08-25 | Innovafood Ab | Food supplement comprising amino acid and chromium |
US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
EP2977047B1 (en) * | 2013-02-26 | 2022-10-19 | Ajinomoto Co., Inc. | Nutrition composition |
WO2015154257A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and, nutritional systems comprising them |
WO2015154251A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them. |
WO2015154254A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them |
WO2015154259A1 (en) * | 2014-04-09 | 2015-10-15 | Nestle (China) Ltd. | Gender specific synthetic nutritional compositions and nutritional systems comprising them |
US20180344677A1 (en) * | 2015-11-27 | 2018-12-06 | Doublegood Ab | Food supplement and composition for treating the metabolic syndrome |
CN110892985A (en) * | 2019-11-28 | 2020-03-20 | 北京诺康达医药科技股份有限公司 | Nutritional preparation suitable for perioperative patients |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3697287A (en) * | 1969-01-28 | 1972-10-10 | Morton Norwich Products Inc | Amino acid food composition |
US4029773A (en) * | 1973-05-25 | 1977-06-14 | Syntex (U.S.A.) Inc. | Composition and method of treating ulcers |
US4070488A (en) * | 1975-11-25 | 1978-01-24 | Davis Rachel D | Nutritive composition |
US4268529A (en) * | 1977-09-02 | 1981-05-19 | Davis Rachel D | Nutritive composition and method of preparing same |
US4220666A (en) * | 1978-02-03 | 1980-09-02 | Desert Merchandising, Inc. | Sucrose-invert sugar protein product and method of manufacture |
JPS56110617A (en) * | 1980-02-08 | 1981-09-01 | Ajinomoto Co Inc | Nutrient composition for young child |
US4357343A (en) * | 1981-06-26 | 1982-11-02 | Baxter Travenol Laboratories, Inc. | Nutritional composition for management of renal failure |
NL8403433A (en) * | 1984-11-09 | 1986-06-02 | Holland Melkunie | FOOD SUPPLY PREPARATION BASED ON MILK COMPONENTS. |
US4833128A (en) * | 1984-12-28 | 1989-05-23 | Neil Solomon | Dietary supplement |
US4871550A (en) * | 1986-09-05 | 1989-10-03 | Millman Phillip L | Nutrient composition for athletes and method of making and using the same |
FR2605854B1 (en) * | 1986-10-30 | 1990-07-06 | Futur Quotidien Sa | DIETARY SUPPLEMENT FOR ENERGY PURPOSES |
-
1990
- 1990-10-26 US US07/604,665 patent/US5132113A/en not_active Expired - Lifetime
-
1991
- 1991-10-22 ES ES91202733T patent/ES2094788T3/en not_active Expired - Lifetime
- 1991-10-22 AT AT91202733T patent/ATE142435T1/en not_active IP Right Cessation
- 1991-10-22 DK DK91202733.1T patent/DK0482715T3/da active
- 1991-10-22 DE DE69122025T patent/DE69122025T2/en not_active Expired - Lifetime
- 1991-10-22 EP EP91202733A patent/EP0482715B1/en not_active Expired - Lifetime
- 1991-10-25 CA CA002054268A patent/CA2054268C/en not_active Expired - Lifetime
- 1991-10-28 JP JP03308541A patent/JP3118289B2/en not_active Expired - Fee Related
-
1996
- 1996-12-11 GR GR960403408T patent/GR3021978T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69122025T2 (en) | 1997-10-23 |
DE69122025D1 (en) | 1996-10-17 |
ES2094788T3 (en) | 1997-02-01 |
GR3021978T3 (en) | 1997-03-31 |
EP0482715A1 (en) | 1992-04-29 |
JP3118289B2 (en) | 2000-12-18 |
US5132113A (en) | 1992-07-21 |
ATE142435T1 (en) | 1996-09-15 |
JPH04346770A (en) | 1992-12-02 |
EP0482715B1 (en) | 1996-09-11 |
DK0482715T3 (en) | 1997-03-03 |
CA2054268A1 (en) | 1992-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2054268C (en) | Nutritional composition | |
US20210275582A1 (en) | Composition of nutrition supplementation for nutritional deficiencies and method of use therefore | |
KR101075816B1 (en) | Total enteral nutritious composition | |
CN100355420C (en) | Leucine-enriched nutritional compositions | |
EP0705542B1 (en) | Adolescent dietary composition | |
US6900180B1 (en) | Pharmaceutical compositions for alleviating discomfort | |
US5242697A (en) | Method of preparing nutrified food products | |
Lagua et al. | Nutrition and diet therapy reference dictionary | |
KR20020089448A (en) | Composition comprising free amino acids | |
CN1212605A (en) | Composition and its use as food supplement or for lowering lipids in serum | |
Giordano et al. | Protein restriction in chronic renal failure | |
US5186963A (en) | Therapeutic dietary composition containing amaranth | |
US5849335A (en) | Composition and method for providing glutamine | |
CA2514687A1 (en) | Advenced vitamin c-based composition with enhanced biotransformation and utilization of protein and l-carnitine for nutritional supplementation or the like | |
US6004926A (en) | Body fat percent-lowering, body composition-improving food composition and a method for lowering the body fat percentage and improving the body composition | |
CN105638900A (en) | Special medical food for patients in emergency states and preparation method thereof | |
Jackson et al. | Nutritional requirements of infants and children | |
KR100266799B1 (en) | Nutritional formula for patients with renal disease and process for preparing the same | |
RU2335927C2 (en) | Nutrient compositions enriched with leucine | |
EP1123013A1 (en) | Product and method for providing glutamine | |
Lagua | AA. Abbreviation for 1. Adenylic acid. 2. Amino acid. 3. Alcoholics Anonymous. AAA. Abbreviation for aromatic amino acid. ABeD. Abbreviation for Advocates for | |
CN115918914A (en) | Oral nutritional supplement containing compound protein, preparation and application | |
Dufour | Nutritional models for space travel from chemically defined diets | |
Marks et al. | Methods and problems of weight reduction | |
Lagua | T. Abbreviation for temperature. T3• Abbreviation for triiodothyronine, a thyroid hormone. See Thyroid gland. T 4'Abbreviation for tetraiodothyronine |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |