CA2056653A1 - Preparation for transdermal drug administration - Google Patents
Preparation for transdermal drug administrationInfo
- Publication number
- CA2056653A1 CA2056653A1 CA2056653A CA2056653A CA2056653A1 CA 2056653 A1 CA2056653 A1 CA 2056653A1 CA 2056653 A CA2056653 A CA 2056653A CA 2056653 A CA2056653 A CA 2056653A CA 2056653 A1 CA2056653 A1 CA 2056653A1
- Authority
- CA
- Canada
- Prior art keywords
- pressure
- sensitive adhesive
- adhesive layer
- preparation
- drug administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000001647 drug administration Methods 0.000 title abstract 3
- 239000010410 layer Substances 0.000 abstract 5
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 4
- 239000003589 local anesthetic agent Substances 0.000 abstract 3
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
Disclosed is a preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in an amount of 40-65 % by weight based on the total weight of the pressure-sensitive adhesive layer. Since the ratio of the amount of undissolved local anesthetic (Ac) to that of dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP338885/1990 | 1990-11-30 | ||
JP2338885A JP2849950B2 (en) | 1990-11-30 | 1990-11-30 | Transdermal formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2056653A1 true CA2056653A1 (en) | 1992-05-31 |
CA2056653C CA2056653C (en) | 2000-08-08 |
Family
ID=18322294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002056653A Expired - Lifetime CA2056653C (en) | 1990-11-30 | 1991-11-29 | Preparation for transdermal drug administration |
Country Status (10)
Country | Link |
---|---|
US (1) | US5368860A (en) |
EP (1) | EP0488137B1 (en) |
JP (1) | JP2849950B2 (en) |
KR (1) | KR0185715B1 (en) |
AT (1) | ATE120642T1 (en) |
CA (1) | CA2056653C (en) |
DE (1) | DE69108683T2 (en) |
DK (1) | DK0488137T3 (en) |
ES (1) | ES2070401T3 (en) |
TW (1) | TW198692B (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020138A2 (en) * | 1992-03-30 | 1993-10-14 | Alza Corporation | Polymer system containing a partially soluble compound |
ATE194281T1 (en) | 1994-09-14 | 2000-07-15 | Minnesota Mining & Mfg | TRANSDERMAL ACTIVE RELEASE MATRIX |
US5573778A (en) * | 1995-03-17 | 1996-11-12 | Adhesives Research, Inc. | Drug flux enhancer-tolerant pressure sensitive adhesive composition |
DE19524691A1 (en) * | 1995-07-06 | 1997-01-09 | Liedtke Pharmed Gmbh | Method and composition of topical therapy for inner ear and labyrinth symptoms |
US5667799A (en) * | 1995-10-30 | 1997-09-16 | Caldwell; Larry J. | Method for treating headache pain with topical local anesthetic compositions |
DE19546159A1 (en) * | 1995-12-11 | 1997-06-12 | Liedtke Pharmed Gmbh | Method and composition of a topically effective therapy for post-operative and post-traumatic wound pain |
US6365178B1 (en) * | 1996-09-06 | 2002-04-02 | Watson Pharmaceuticals, Inc. | Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions |
US5985317A (en) * | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
US6103771A (en) * | 1998-03-20 | 2000-08-15 | Caldwell Galer Incorporated | Method of treating neuroma pain |
CA2343100A1 (en) * | 1998-09-08 | 2000-05-04 | Srinivasan Venkateshwaran | Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs |
EP1280485A4 (en) * | 2000-02-29 | 2006-11-29 | Zars Inc | Improved transdermal drug patch |
EP1747033A1 (en) | 2004-04-30 | 2007-01-31 | Burrell E. Clawson | Apparatus and methods for isolating human body areas for localized cooling |
US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
WO2006037047A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
US7718674B2 (en) * | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
JP2006248996A (en) * | 2005-03-10 | 2006-09-21 | Nitto Denko Corp | Percutaneous absorption type cataplasm |
WO2008011161A2 (en) * | 2006-07-21 | 2008-01-24 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
US8337883B2 (en) | 2006-11-03 | 2012-12-25 | Durect Corporation | Transdermal delivery systems |
PL2344329T3 (en) | 2008-10-02 | 2013-05-31 | Mylan Inc | Method of making a multilayer adhesive laminate |
KR101080380B1 (en) | 2009-08-14 | 2011-11-04 | 한국수력원자력 주식회사 | Film for adhesion of hydrogel having enhanced adhesive strength and preparation method thereof |
AU2016259348B9 (en) * | 2010-04-13 | 2018-11-29 | Relmada Therapeutics, Inc. | Dermal pharmaceutical compositions of 1-Methyl-2',6' pipecoloxylidide and method of use |
CA2796575C (en) * | 2010-04-13 | 2018-05-15 | Relmada Therapeutics, Inc. | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use |
DE102011100619A1 (en) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Therapeutic system, useful to treat chronic pain, comprises active agent impermeable carrier, active agent reservoir containing e.g. opioid receptor agonist, optionally active agent-permeable membrane and active agent impermeable layer |
US10420837B2 (en) * | 2014-10-02 | 2019-09-24 | Nitto Denko Corporation | Vaccine pharmaceutical composition for transdermal administration |
CN109316469B (en) * | 2018-10-09 | 2022-02-22 | 北京德默高科医药技术有限公司 | Stable high-drug-loading lidocaine transdermal patch and preparation method thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58148815A (en) * | 1982-02-26 | 1983-09-05 | Nitto Electric Ind Co Ltd | Preparation of complex medicinal pharmaceutical |
EP0156080B2 (en) * | 1984-03-05 | 1993-10-20 | Nitto Denko Corporation | Percutaneous absorption type adhesive pharmaceutical preparation |
US4655768A (en) * | 1984-07-06 | 1987-04-07 | Avery International Corporation | Bandage for sustained delivery of drugs |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
EP0331392A3 (en) * | 1988-03-01 | 1990-02-14 | Alza Corporation | Anesthesia and antisepsis of the skin |
PT90784A (en) * | 1988-06-09 | 1989-12-29 | Alza Corp | Process for the preparation of a composition of materials for application on a body or limb |
US5120325A (en) * | 1991-06-12 | 1992-06-09 | Fleshtones Products Co., Inc. | Color-matched sterile adhesive bandages containing melanin-like pigment composition |
-
1990
- 1990-11-30 JP JP2338885A patent/JP2849950B2/en not_active Expired - Lifetime
-
1991
- 1991-11-19 TW TW080109062A patent/TW198692B/zh not_active IP Right Cessation
- 1991-11-26 ES ES91120100T patent/ES2070401T3/en not_active Expired - Lifetime
- 1991-11-26 DK DK91120100.2T patent/DK0488137T3/en active
- 1991-11-26 US US07/798,149 patent/US5368860A/en not_active Expired - Lifetime
- 1991-11-26 DE DE69108683T patent/DE69108683T2/en not_active Expired - Lifetime
- 1991-11-26 AT AT91120100T patent/ATE120642T1/en not_active IP Right Cessation
- 1991-11-26 EP EP91120100A patent/EP0488137B1/en not_active Expired - Lifetime
- 1991-11-29 CA CA002056653A patent/CA2056653C/en not_active Expired - Lifetime
- 1991-11-29 KR KR1019910021715A patent/KR0185715B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0488137B1 (en) | 1995-04-05 |
DE69108683T2 (en) | 1995-10-05 |
DK0488137T3 (en) | 1995-08-28 |
KR0185715B1 (en) | 1999-05-01 |
TW198692B (en) | 1993-01-21 |
JPH04208229A (en) | 1992-07-29 |
ES2070401T3 (en) | 1995-06-01 |
KR920009387A (en) | 1992-06-25 |
EP0488137A2 (en) | 1992-06-03 |
EP0488137A3 (en) | 1993-02-03 |
DE69108683D1 (en) | 1995-05-11 |
ATE120642T1 (en) | 1995-04-15 |
CA2056653C (en) | 2000-08-08 |
JP2849950B2 (en) | 1999-01-27 |
US5368860A (en) | 1994-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |