CA2056653A1 - Preparation for transdermal drug administration - Google Patents

Preparation for transdermal drug administration

Info

Publication number
CA2056653A1
CA2056653A1 CA2056653A CA2056653A CA2056653A1 CA 2056653 A1 CA2056653 A1 CA 2056653A1 CA 2056653 A CA2056653 A CA 2056653A CA 2056653 A CA2056653 A CA 2056653A CA 2056653 A1 CA2056653 A1 CA 2056653A1
Authority
CA
Canada
Prior art keywords
pressure
sensitive adhesive
adhesive layer
preparation
drug administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2056653A
Other languages
French (fr)
Other versions
CA2056653C (en
Inventor
Masaki Sunami
Koji Maruyama
Mitsuhiko Hori
Shoichi Tokuda
Kenichiro Saito
Ikuo Kishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Denko Corp
Original Assignee
Masaki Sunami
Koji Maruyama
Mitsuhiko Hori
Shoichi Tokuda
Kenichiro Saito
Ikuo Kishi
Nitto Denko Corporation
Lederle (Japan), Ltd.
Wyeth Lederle Japan, Ltd.
Wyeth K.K.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Masaki Sunami, Koji Maruyama, Mitsuhiko Hori, Shoichi Tokuda, Kenichiro Saito, Ikuo Kishi, Nitto Denko Corporation, Lederle (Japan), Ltd., Wyeth Lederle Japan, Ltd., Wyeth K.K. filed Critical Masaki Sunami
Publication of CA2056653A1 publication Critical patent/CA2056653A1/en
Application granted granted Critical
Publication of CA2056653C publication Critical patent/CA2056653C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

Disclosed is a preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in an amount of 40-65 % by weight based on the total weight of the pressure-sensitive adhesive layer. Since the ratio of the amount of undissolved local anesthetic (Ac) to that of dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.
CA002056653A 1990-11-30 1991-11-29 Preparation for transdermal drug administration Expired - Lifetime CA2056653C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2338885A JP2849950B2 (en) 1990-11-30 1990-11-30 Transdermal formulation
JP338885/1990 1990-11-30

Publications (2)

Publication Number Publication Date
CA2056653A1 true CA2056653A1 (en) 1992-05-31
CA2056653C CA2056653C (en) 2000-08-08

Family

ID=18322294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002056653A Expired - Lifetime CA2056653C (en) 1990-11-30 1991-11-29 Preparation for transdermal drug administration

Country Status (10)

Country Link
US (1) US5368860A (en)
EP (1) EP0488137B1 (en)
JP (1) JP2849950B2 (en)
KR (1) KR0185715B1 (en)
AT (1) ATE120642T1 (en)
CA (1) CA2056653C (en)
DE (1) DE69108683T2 (en)
DK (1) DK0488137T3 (en)
ES (1) ES2070401T3 (en)
TW (1) TW198692B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9301817A (en) * 1992-03-30 1994-01-31 Alza Corp POLYMERIC SYSTEM CONTAINING A PARTIALLY SOLUBLE COMPOUND.
ATE194281T1 (en) 1994-09-14 2000-07-15 Minnesota Mining & Mfg TRANSDERMAL ACTIVE RELEASE MATRIX
US5573778A (en) * 1995-03-17 1996-11-12 Adhesives Research, Inc. Drug flux enhancer-tolerant pressure sensitive adhesive composition
DE19524691A1 (en) * 1995-07-06 1997-01-09 Liedtke Pharmed Gmbh Method and composition of topical therapy for inner ear and labyrinth symptoms
US5667799A (en) * 1995-10-30 1997-09-16 Caldwell; Larry J. Method for treating headache pain with topical local anesthetic compositions
DE19546159A1 (en) * 1995-12-11 1997-06-12 Liedtke Pharmed Gmbh Method and composition of a topically effective therapy for post-operative and post-traumatic wound pain
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US6365178B1 (en) * 1996-09-06 2002-04-02 Watson Pharmaceuticals, Inc. Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
US6103771A (en) * 1998-03-20 2000-08-15 Caldwell Galer Incorporated Method of treating neuroma pain
EP1117389A1 (en) * 1998-09-08 2001-07-25 TheraTech, Inc. Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs
EP1280485A4 (en) * 2000-02-29 2006-11-29 Zars Inc Improved transdermal drug patch
CA2564822A1 (en) 2004-04-30 2005-11-17 Burrell E. Clawson Apparatus and methods for isolating human body areas for localized cooling
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
WO2006036936A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
US20060079558A1 (en) * 2004-09-27 2006-04-13 Bridge Pharma. Inc. R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics
JP2006248996A (en) * 2005-03-10 2006-09-21 Nitto Denko Corp Percutaneous absorption type cataplasm
CA2655809C (en) * 2006-07-21 2013-10-01 Bridge Pharma, Inc. Dermal anesthetic compounds
ES2388355T3 (en) 2006-11-03 2012-10-11 Durect Corporation Transdemic delivery systems comprising bupivacaine
US8142592B2 (en) 2008-10-02 2012-03-27 Mylan Inc. Method for making a multilayer adhesive laminate
KR101080380B1 (en) 2009-08-14 2011-11-04 한국수력원자력 주식회사 Film for adhesion of hydrogel having enhanced adhesive strength and preparation method thereof
AU2016259348B9 (en) * 2010-04-13 2018-11-29 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-Methyl-2',6' pipecoloxylidide and method of use
CN107115326B (en) * 2010-04-13 2021-01-22 雷尔玛达治疗股份有限公司 Skin pharmaceutical composition of 1-methyl-N- (2, 6-xylyl) -2-piperidine formamide and using method thereof
DE102011100619A1 (en) 2010-05-05 2012-01-05 Amw Gmbh Therapeutic system, useful to treat chronic pain, comprises active agent impermeable carrier, active agent reservoir containing e.g. opioid receptor agonist, optionally active agent-permeable membrane and active agent impermeable layer
EP3202417A4 (en) * 2014-10-02 2018-04-25 Nitto Denko Corporation Vaccine pharmaceutical composition for transdermal administration
CN109316469B (en) * 2018-10-09 2022-02-22 北京德默高科医药技术有限公司 Stable high-drug-loading lidocaine transdermal patch and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58148815A (en) * 1982-02-26 1983-09-05 Nitto Electric Ind Co Ltd Preparation of complex medicinal pharmaceutical
ATE42901T1 (en) * 1984-03-05 1989-05-15 Nitto Denko Corp ADHESIVE MEDICATION FOR PERCUTANEOUS ABSORPTION.
US4655768A (en) * 1984-07-06 1987-04-07 Avery International Corporation Bandage for sustained delivery of drugs
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
EP0331392A3 (en) * 1988-03-01 1990-02-14 Alza Corporation Anesthesia and antisepsis of the skin
JPH03501386A (en) * 1988-06-09 1991-03-28 アルザ・コーポレーション Permeation enhancers including ethanol and glycerol monooleate
US5120325A (en) * 1991-06-12 1992-06-09 Fleshtones Products Co., Inc. Color-matched sterile adhesive bandages containing melanin-like pigment composition

Also Published As

Publication number Publication date
EP0488137A2 (en) 1992-06-03
ES2070401T3 (en) 1995-06-01
KR920009387A (en) 1992-06-25
EP0488137A3 (en) 1993-02-03
US5368860A (en) 1994-11-29
KR0185715B1 (en) 1999-05-01
TW198692B (en) 1993-01-21
DK0488137T3 (en) 1995-08-28
JP2849950B2 (en) 1999-01-27
DE69108683T2 (en) 1995-10-05
EP0488137B1 (en) 1995-04-05
CA2056653C (en) 2000-08-08
DE69108683D1 (en) 1995-05-11
JPH04208229A (en) 1992-07-29
ATE120642T1 (en) 1995-04-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202