CA2056743A1 - Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control - Google Patents

Thermal Cycler for Automatic Performance of the Polymerase Chain Reaction with Close Temperature Control

Info

Publication number
CA2056743A1
CA2056743A1 CA2056743A CA2056743A CA2056743A1 CA 2056743 A1 CA2056743 A1 CA 2056743A1 CA 2056743 A CA2056743 A CA 2056743A CA 2056743 A CA2056743 A CA 2056743A CA 2056743 A1 CA2056743 A1 CA 2056743A1
Authority
CA
Canada
Prior art keywords
chain reaction
polymerase chain
temperature control
thermal cycler
automatic performance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2056743A
Other languages
French (fr)
Other versions
CA2056743C (en
Inventor
Albert C. Mossa
Lisa M. Goven
John G. Atwood
Fenton Williams
Timothy M. Woudenberg
Marcel Margulies
Robert P. Ragusa
Richard Leath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems Inc
Original Assignee
Albert C. Mossa
Lisa M. Goven
John G. Atwood
Fenton Williams
Timothy M. Woudenberg
Marcel Margulies
Robert P. Ragusa
Richard Leath
Perkin-Elmer/Cetus Instruments
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27088746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2056743(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albert C. Mossa, Lisa M. Goven, John G. Atwood, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Perkin-Elmer/Cetus Instruments filed Critical Albert C. Mossa
Priority to CA002266010A priority Critical patent/CA2266010C/en
Publication of CA2056743A1 publication Critical patent/CA2056743A1/en
Application granted granted Critical
Publication of CA2056743C publication Critical patent/CA2056743C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1927—Control of temperature characterised by the use of electric means using a plurality of sensors
    • G05D23/193—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces
    • G05D23/1935—Control of temperature characterised by the use of electric means using a plurality of sensors sensing the temperaure in different places in thermal relationship with one or more spaces using sequential control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D23/00—Control of temperature
    • G05D23/19—Control of temperature characterised by the use of electric means
    • G05D23/1917—Control of temperature characterised by the use of electric means using digital means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Abstract

An apparatus and control system for performing automated polymerase chain reaction (PCT) comprises a sample block (12) having wells for holding sample tubes (10), a computer controller (20), heating (14,156) and cooling (34,40) elements and a temperature sensor (21). The computer controller (20) monitors the temperature of the sample block (12) over time to determine the temperature of the liquid samples (10) and adjust the heating or cooling applied to the sample tubes (10) in order to provide for an optimal or desired PCR procedure.
CA002056743A 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control Expired - Lifetime CA2056743C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002266010A CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62060690A 1990-11-29 1990-11-29
US620,606 1990-11-29
US67054591A 1991-03-14 1991-03-14
US670,545 1991-03-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002266010A Division CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Publications (2)

Publication Number Publication Date
CA2056743A1 true CA2056743A1 (en) 1992-05-30
CA2056743C CA2056743C (en) 1999-04-13

Family

ID=27088746

Family Applications (4)

Application Number Title Priority Date Filing Date
CA002056743A Expired - Lifetime CA2056743C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002266010A Expired - Lifetime CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002395941A Expired - Lifetime CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002436618A Expired - Lifetime CA2436618C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA002266010A Expired - Lifetime CA2266010C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002395941A Expired - Lifetime CA2395941C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
CA002436618A Expired - Lifetime CA2436618C (en) 1990-11-29 1991-11-29 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control

Country Status (14)

Country Link
US (4) US5475610A (en)
EP (8) EP0488769B1 (en)
JP (7) JPH06233670A (en)
KR (1) KR100236506B1 (en)
AT (6) ATE261774T1 (en)
AU (2) AU662494B2 (en)
CA (4) CA2056743C (en)
DE (11) DE1157744T1 (en)
DK (4) DK0488769T3 (en)
ES (3) ES2318232T3 (en)
GR (1) GR920300125T1 (en)
IE (2) IE20080750A1 (en)
IL (5) IL111092A (en)
NZ (3) NZ270629A (en)

Cited By (3)

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US5683659A (en) * 1995-02-22 1997-11-04 Hovatter; Kenneth R. Integral assembly of microcentrifuge strip tubes and strip caps
US9108772B2 (en) 2013-03-15 2015-08-18 Scientific Specialties, Inc. Container latching systems for one-handed operation
CN113275057A (en) * 2015-07-23 2021-08-20 塞弗德公司 Thermal control device and method of use thereof

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