CA2061567A1 - Use of hyaluronic acid to repair ischemia reperfusion damage - Google Patents
Use of hyaluronic acid to repair ischemia reperfusion damageInfo
- Publication number
- CA2061567A1 CA2061567A1 CA2061567A CA2061567A CA2061567A1 CA 2061567 A1 CA2061567 A1 CA 2061567A1 CA 2061567 A CA2061567 A CA 2061567A CA 2061567 A CA2061567 A CA 2061567A CA 2061567 A1 CA2061567 A1 CA 2061567A1
- Authority
- CA
- Canada
- Prior art keywords
- hyaluronic acid
- repair
- ischemia reperfusion
- reperfusion damage
- damage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
Abstract
A pharmaceutical composition comprising an effective non-toxic amount of hyaluronic acid (HA) and or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and units of HA in association with a suitable diluent or pharmaceutically acceptable carrier for use in treating ischemia damage in tissue.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002061567A CA2061567C (en) | 1992-02-20 | 1992-02-20 | Use of hyaluronic acid to repair ischemia reperfusion damage |
SG1996002901A SG49654A1 (en) | 1992-02-20 | 1993-02-19 | The use of hyaluronic acid to repair ischemia reperfusion damage |
EP93301230A EP0557118A1 (en) | 1992-02-20 | 1993-02-19 | The use of hyaluronic acid to repair ischemia reperfusion damage |
US08/200,309 US5674857A (en) | 1992-02-20 | 1994-02-23 | Use of hyaluronic acid to repair ischemia reperfusion damage |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002061567A CA2061567C (en) | 1992-02-20 | 1992-02-20 | Use of hyaluronic acid to repair ischemia reperfusion damage |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2061567A1 true CA2061567A1 (en) | 1993-08-21 |
CA2061567C CA2061567C (en) | 1998-02-03 |
Family
ID=4149301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002061567A Expired - Lifetime CA2061567C (en) | 1992-02-20 | 1992-02-20 | Use of hyaluronic acid to repair ischemia reperfusion damage |
Country Status (4)
Country | Link |
---|---|
US (1) | US5674857A (en) |
EP (1) | EP0557118A1 (en) |
CA (1) | CA2061567C (en) |
SG (1) | SG49654A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5834444A (en) * | 1991-07-03 | 1998-11-10 | Hyal Pharmaceutical Corporation | Hyaluronic acid and salts thereof inhibit arterial restenosis |
CA2130762C (en) * | 1994-08-24 | 1999-07-06 | Eva Anne Turley | Treatment of disease and conditions associated with macrophage infiltration |
US5585361A (en) * | 1994-06-07 | 1996-12-17 | Genzyme Corporation | Methods for the inhibition of platelet adherence and aggregation |
US5591724A (en) * | 1995-02-14 | 1997-01-07 | Bioniche Inc. | Method for treating the urinary bladder and associated structures using hyaluronic acid |
JP4627580B2 (en) * | 2000-06-08 | 2011-02-09 | 生化学工業株式会社 | Liver disease treatment |
WO2002035929A1 (en) * | 2000-11-03 | 2002-05-10 | Vitrolife Ab | Evaluation and preservation solution |
JP4537057B2 (en) | 2001-08-14 | 2010-09-01 | テルアビブ・ユニバーシティ・フューチャー・テクノロジー・デベロップメント・エルピー | Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and treatment |
US9241735B2 (en) | 2003-12-05 | 2016-01-26 | Onset Medical Corporation | Expandable percutaneous sheath |
CA2560200A1 (en) * | 2004-03-17 | 2005-09-22 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Cd44-targeting for reducing/preventing ischemia-reperfusion-injury |
US20060135962A1 (en) | 2004-09-09 | 2006-06-22 | Kick George F | Expandable trans-septal sheath |
US7892203B2 (en) | 2004-09-09 | 2011-02-22 | Onset Medical Corporation | Expandable transluminal sheath |
US8337518B2 (en) | 2006-12-20 | 2012-12-25 | Onset Medical Corporation | Expandable trans-septal sheath |
GB0913442D0 (en) | 2009-07-31 | 2009-09-16 | Univ Ramot | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
JP6091415B2 (en) * | 2010-10-07 | 2017-03-08 | ナショナル チェン クン ユニバーシティー | Use of hyaluronan to promote ischemic limb blood flow in diabetes |
IN2014MN01886A (en) | 2012-04-18 | 2015-07-10 | Univ Ramot | |
EP3160448A4 (en) | 2014-06-26 | 2018-11-14 | Ramot at Tel-Aviv University Ltd. | Liposomal formulations for delivery of nucleic acids |
CN112972490B (en) * | 2021-03-04 | 2022-02-18 | 中国人民解放军军事科学院军事医学研究院 | Application of hyaluronic acid in preparing medicine for preventing or treating iron death related diseases |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
US4303676A (en) * | 1980-03-21 | 1981-12-01 | Balazs Endre A | Hyaluronate based compositions and cosmetic formulations containing same |
US4684627A (en) * | 1981-09-08 | 1987-08-04 | Leveen Harry H | Treatment of cancer with phlorizin and its derivatives |
US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
IT1229075B (en) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Topical compsn. contg. hyaluronic acid deriv. as vehicle |
AU555747B2 (en) * | 1983-08-09 | 1986-10-09 | Cilco Inc. | Chondroitin sulfate and sodium hyaluronate composition |
IN163192B (en) * | 1983-10-11 | 1988-08-20 | Fidia Spa | |
NO161573C (en) * | 1983-11-25 | 1989-08-30 | Miles Inc | PROCEDURE FOR THE PREPARATION OF HYALURONIC ACID. |
CA1295796C (en) * | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
JPS6117A (en) * | 1984-06-11 | 1986-01-06 | Seikagaku Kogyo Co Ltd | Mucopolysaccharide-type cancer-metastatis suppressing agent |
US4711780A (en) * | 1984-06-11 | 1987-12-08 | Fahim Mostafa S | Composition and process for promoting epithelial regeneration |
US4735902A (en) * | 1984-10-23 | 1988-04-05 | Matti Siren | Stabilized composition containing inositoltriphosphate |
US4636524A (en) * | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
EP0187703B1 (en) * | 1985-01-11 | 1992-08-05 | Teijin Limited | Sustained release preparation |
US4784990A (en) * | 1985-01-18 | 1988-11-15 | Bio-Technology General Corporation | High molecular weight sodium hyaluronate |
US4719201A (en) * | 1985-02-07 | 1988-01-12 | Regents Of The University Of Minnesota | Method for stimulating recovery from ischemia |
US4713448A (en) * | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
SE8501723L (en) * | 1985-04-09 | 1986-10-10 | Pharmacia Ab | PREPARATION TO BE USED IN TREATMENT OF LED INFLAMMATION |
US4725585A (en) * | 1985-04-26 | 1988-02-16 | Pharmacia Ab | Method of enhancing the host defense |
EP0207638B1 (en) * | 1985-06-04 | 1990-12-19 | Teijin Limited | Sustained-release pharmaceutical preparation |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
FR2584606A1 (en) * | 1985-07-12 | 1987-01-16 | Dropic | USE OF POLY- AND OLIGOSACCHARIDES FOR THE PRODUCTION OF ACTIVE MEDICAMENTS IN THE PATHOLOGIES OF CONNECTIVE TISSUE |
IN166447B (en) * | 1985-11-27 | 1990-05-12 | Ethicon Inc | |
EP0224987B1 (en) * | 1985-11-29 | 1992-04-15 | Biomatrix, Inc. | Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same |
JP2604135B2 (en) * | 1986-02-28 | 1997-04-30 | ライオン株式会社 | Oral bone disease treatment |
EP0240098A3 (en) * | 1986-04-04 | 1989-05-10 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Oligo and polysaccharides for the treatment of diseases caused by retroviruses |
EP0244178A3 (en) * | 1986-04-28 | 1989-02-08 | Iolab, Inc | Intraocular dosage compositions and method of use |
US4808576A (en) * | 1986-04-28 | 1989-02-28 | Mobay Corporation | Remote administration of hyaluronic acid to mammals |
IT1213301B (en) * | 1986-07-14 | 1989-12-20 | Zambon Spa | COMPOSITIONS FOR THE TREATMENT OF SYNDROMES FROM ISCHEMIA AND REPERFUSION |
IT1198449B (en) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | ESTERS OF POLYVALENT ALCOHOLS OF HYALURONIC ACID |
ZA878877B (en) * | 1986-11-29 | 1988-05-24 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of diseases caused by viruses |
GB8706052D0 (en) * | 1987-03-13 | 1987-04-15 | Medical Research Int | Therapeutic compositions |
ATE129254T1 (en) * | 1987-03-19 | 1995-11-15 | Arthropharm Pty Ltd | ANTI-INFLAMMATORY AGENTS AND COMPOSITIONS. |
EP0285357A3 (en) * | 1987-03-31 | 1989-10-25 | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo | Control of retroviruses |
US4795741A (en) * | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
GB8713747D0 (en) * | 1987-06-12 | 1987-07-15 | Unilever Plc | Skin treatment composition |
US4931460A (en) * | 1987-09-17 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Post-ischemic myocardial dysfunction using thromboxane A2 antagonists |
NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
US4968671A (en) * | 1987-11-26 | 1990-11-06 | Yamanouchi Pharmaceutical Co., Ltd. | Therapeutic agents for ischemic heart diseases |
US4988515A (en) * | 1988-01-28 | 1991-01-29 | The Regents Of The Univ. Of Calif. | Cardioplegic solution |
DK505588D0 (en) * | 1988-02-26 | 1988-09-09 | Jesper Hamburger | MEDIUM AND USE OF SAME |
JPH01287041A (en) * | 1988-05-13 | 1989-11-17 | Rooman Kogyo:Kk | Sustained release preparation |
IT1219587B (en) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES |
US5057494A (en) * | 1988-08-03 | 1991-10-15 | Ethicon, Inc. | Method for preventing tissue damage after an ischemic episode |
CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
US5095037B1 (en) * | 1989-12-21 | 1995-12-19 | Nissho Kk | Combined anti-inflammatory agent |
WO1991015215A1 (en) * | 1990-03-30 | 1991-10-17 | Biomedical Frontiers, Inc. | Fluid resuscitation |
US5099012A (en) * | 1990-12-11 | 1992-03-24 | Eastman Kodak Company | Chroman-2-carboxamide conjugates and their use for treatment of reperfusion injury |
US5095027A (en) * | 1991-02-28 | 1992-03-10 | Clintec Nutrition Co. | Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid |
DE19538814C2 (en) * | 1995-10-18 | 1998-07-09 | Obermaier Geb Ohg | Foot massager |
-
1992
- 1992-02-20 CA CA002061567A patent/CA2061567C/en not_active Expired - Lifetime
-
1993
- 1993-02-19 EP EP93301230A patent/EP0557118A1/en not_active Ceased
- 1993-02-19 SG SG1996002901A patent/SG49654A1/en unknown
-
1994
- 1994-02-23 US US08/200,309 patent/US5674857A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5674857A (en) | 1997-10-07 |
EP0557118A1 (en) | 1993-08-25 |
CA2061567C (en) | 1998-02-03 |
SG49654A1 (en) | 1998-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |