CA2075500C - Unit dose assembly - Google Patents
Unit dose assembly Download PDFInfo
- Publication number
- CA2075500C CA2075500C CA002075500A CA2075500A CA2075500C CA 2075500 C CA2075500 C CA 2075500C CA 002075500 A CA002075500 A CA 002075500A CA 2075500 A CA2075500 A CA 2075500A CA 2075500 C CA2075500 C CA 2075500C
- Authority
- CA
- Canada
- Prior art keywords
- tube
- nozzle
- cap
- section
- thin wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
- B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
- B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
- B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
- B65D51/222—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being integral with, or fixedly attached to, the outer closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/36—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for applying contents to surfaces
- B65D35/38—Nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
- B67B7/24—Hole-piercing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0006—Upper closure
- B65D2251/0015—Upper closure of the 41-type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2251/00—Details relating to container closures
- B65D2251/0003—Two or more closures
- B65D2251/0068—Lower closure
- B65D2251/0093—Membrane
- B65D2251/0096—Membrane integral with the container
Abstract
A cap and tube assembly device, including a tube (II) for containing a product, a nozzle having one end mounted to one end of the tube and having a thin wall section (23) puncturable to provide a discharge on the other end and a cap (17). The nozzle has a smaller axial cross section than the tube. The junction of the tube and the nozzle define an inclined surface of transition (15) to permit flow without cavitation from the tube to the nozzle. The cap has an inside cross section sized to engage the nozzle and an outside cross section less than the inside cross section of the tube. The cap has an axially centered puncture spike (33) positioned in a first position spaced from the thin wall and movable to a second position to puncture the thin wall. The puncture means includes a chisel shaped edge (37) for forming a hole in the thin wall without fragmenting the wall. Also provided are ribs (27a, b, c) positioned in the tube for preventing entry of the cap into the nozzle when a plurality of these assemblies are stacked one on another.
Description
WO 91/1198 ~~~ ~~~~ P~flUS9~/00851 I~. '..:
,.. . , . , IT1~IT DOSE ASSEMBLY
TECHI~IGAL FIELD
This invention xelates to unit dose assembly devices and~more particularly to a.cap and tube assembly in which a unit dose is provided in a tube. The tube may contain a single dose of meda.cine, vitamins, eye drops, . or other pharmaceutically related products. The device is particularly suitable for.use with sterile medicaments which need to be protected by the container prior to use.
., . : .: . .: : ~ : . y w' .
. . .. . _ ~(':! .'(: . "-? ' .~':1 , ... . ."... _ , :,'' ..
.
: r Ti C:
.,3 :3'i :'!:':~F ~: ~
~ Y ' ~. .
.: %.~ L G:i ~ t ii"
. . _ .._... ..... ' ..
.. . ' .
.. .. ... _... .,. -. >
, .... .
i-~'.z .L:;~.:..'., .:1".i.:3t,:~._,~... ;:.i,.,.e..W; a._.~:::r;..x ~..::;;s.
'.. ~, , .. ..J::::. . ,..._.....~:.._~...,..._ ."T : ..:.!.'_....
. ,_. ...",., t; :~~,~r'.rr.a._ ..;1 :r i.; ' ._, . , a~:!'r: .
' ...., .... ... .. , _...
_ L .. " _ .. , , ,.~ _....
..... i.~.i1',~'a "; . .:l;:ruJs.~ .~..:... .... i-: Y!) fiY::~ei .
:;..:i<
.....,..
.
a ..
.
..
_ ~v~ g~uz~~s ' ; :' : . ~ ... ~crius9~ioossa B~lCRGR~UND A'~T
Cap and tube assemblies which carry medicines, vitamins, and the like have obtained significant interest , in the pharmaceutical industry. Not only is there a concern for resistance to undesirable tampering, such as by a child, there. is increasing interest in insuring that the entire dose contained in the container is delivered w to the patient and that no parts of the container itself contact the patient.
In my recent patent, U.S. latent No. 4,67,326, I
have provided an excellent design for a child resistant cap. The design described in my patent is of great value in providing a product wherein there is easy inspection of unit dose sterile medicaments in a cap and tube assembly which is child resistant and suitable for a high reliability pass/fail inspection.
Depending upon the size of the tube, the thickness of the thin wall, and the shape of the piercer, tearing the plastic thin wall causes pieces to~break off. These small pieces of plastic are inert, and normally axe not harmful. Howevex, particularly when the contents are eye drops, it would be of great advantage if the possibility of small pieces of plastic breaking. off could be reduced WdD 91/12198 PC~'/US91/~851 ..
::- ;.. v'~.;.'~;
to the absolute minimum, if not totally eliminated.
Accordingly, that is one of the objects of the present invention.
Also, the junction between °the tube and the portion of the tubs which forms the discharge structure for a cap and 'tube assembly often times includes a sharp junction, as would necessarily happen if the discharge nozzle was merely joined to the tube using conventional technology.
In this case, sometimes when the product is dispensed from the tube, one or two drops are :trapped on what becomes a ledge or ring at the junction between the tube and the discharge nozzle. When it is important that the entire dose be received by the user, failure to remove these one or two drops:.provides a:less.-than: complete treatment o - Accordingly, .. it : ~ is aazother ob j ect of .~ this invention to . provide ; ~ design wha.ch allows ~ for total evacuation of '~th~ -tube. ~ . .. . ...:
, . . -~ : - :~:; :. > . ... :; , -: :~: ..: ::.;::
.-..~ . . _..:r.Tn order-to.-increase=the .efficiency of: cap.and_tube -a='.~ assemblies ~~ dining-.ahe ~:~-filling '~step;vi~:particularly -rwhen ~~ automated assembly is -'~ employed, its°=::is-' necessary to rapidly transfer larg~~~r.~'quantities w=of :~ :°cap.::-and ~ tube assemblies to the filling. machine. This is best accomplished by stacking a plurality of assemblies, with ViYO 91/12198 PCTJU691/00851 the assembled cap and tube being sized to fit inside other unfilled cap and tube assemblies. It is also necessary that these stacked assemblies be readily separable with a minimum amount of force, such as in a .
gravity feed ~so that the automated assembly equipment does not become jammed or otherwise malfunctioned. When this stacking feature is contemplated, it is necessary, of course, to size the cap portion so that it fits within the interior~of the adjacent tube. Similarly, the cap cannot be so small that it fits into the nozzle.
Accordingly, it object of .this invention to provide a cap and tube assembly which is suitable for stacking.
When the junction between the tube and the discharge nozzle is a conventional. junction, such as when the tube..and nozzle are merely.joined together, the ring , .~or r ridge-::.which is formed at 'that -~ junction . has the .potential-:.for the cap becoming stuck in that_.junction, thereby causing a difficulty in the_separationof two stacked assemblies. If the cap strikes the junction .....:: between : the ~~tube -sand a nozzle : at an angle,-. there is the .c-,,:Y-,very::,real ~ danger ;:.that : the ' cap ~ will , become -wedged ::in the orifiae;~thereby jamming =~. or otherwise delaying :; the ~.; :~::: operationvof-cassembly. ~equipmen~t. _._. .. .;.: . ... . .
25:~c~ :.~ _. ~. ~. . ,........... , s .; . .. :v ~:-i', ~. ~ -:~..~;:;:~~....
~ .. : , ,!.":.6>~ , :: ~ . ::7:. ., ,, ~~- :, '' :.~> .: . , vl ,. . . ., ._ , _,.. _ , .," . ...
1%~~ 91/12198 ,..r... PC~'/LJS91/00851 1~~,'6~~~~~'~
DT CL~SDRE ~F T:S>; T~i'l.'TOP7 Tt has now been discovered that the above and other objects of the present invention may .be accomplished in the following manner. Specifically, a cap and tube assembly has been discovered which includes the following components.
First, there is a tube for containing a product. A
nozzle is also included,:having one end.mounted,to one -end of the tube. The nozzle has at its other end a thin wall section which is punctu~able to provide a discharge from the device. The nozzle has a smaller axial cross section than the tube. The function of the tube and nozzle is constructed to:.:define an inclined surface of transition from the larger cross section of the tube to the smaller cross section of the nozzle. The surface will~..~ resemble a.funnel, having an . axial cross section which .-begins with_ ..the .:.larger cross section . of the tube' '~-and decreases :ao ::the smaller cross section.,~f 'the _nozzle -~~= "'_' to 'formvthevinclined :surface of :.transition. =~:This;;surface .:~:r :.of'ritransition-,:will permit=..flow: of:the':contents ~ra'x.thout y °' ?.r:Cwitation, =even s:when::~ahe.fluid=: is.; very ~;.nonwiscous such '., ~-as,- 'for example; eye drops. . ... ~~::- . ,.-. _ . .. .
251 i::~". .. ::~' :'~t::v.;"~:'~,-] ?:-._:'..'T .,a~ '...,.... ...:~..)'.
....,,.' _~ , . ..
n VdU 91/12198 F > : : . ,. PCf/US91/00851 ' . ..
The cap and tube assembly of the present invention includes a cap which has an inside cross section which is sized to engage the nozzle. It also has an outside cross , ;
section which is.less than the inside cross section of the tube, so that the tubes can be stacked on top. of. caps as will be described hereinafter.
The cap has an axially centered puncture means TO which 'is positioned in a first position spaced from the thin wall of the nozzle and is movable to aesecond position to puncture.the thin wall and provide access to the contents therein. The puncture means is preferably one which includes a chisel shaped edged~for forming a hole in the wall w~.thout fragmenting the thin wall of the nozzle: . : v.. .
.. In~ another::embodiment :of.ahe present.: invention, .. . there= ~ is .. provided :: a : means .. pos itioned in the . tube f or ~ preventing ~~ entry of ~: .the .,:.cap into -: he . nozzle when ~ .
,.. . , . , IT1~IT DOSE ASSEMBLY
TECHI~IGAL FIELD
This invention xelates to unit dose assembly devices and~more particularly to a.cap and tube assembly in which a unit dose is provided in a tube. The tube may contain a single dose of meda.cine, vitamins, eye drops, . or other pharmaceutically related products. The device is particularly suitable for.use with sterile medicaments which need to be protected by the container prior to use.
., . : .: . .: : ~ : . y w' .
. . .. . _ ~(':! .'(: . "-? ' .~':1 , ... . ."... _ , :,'' ..
.
: r Ti C:
.,3 :3'i :'!:':~F ~: ~
~ Y ' ~. .
.: %.~ L G:i ~ t ii"
. . _ .._... ..... ' ..
.. . ' .
.. .. ... _... .,. -. >
, .... .
i-~'.z .L:;~.:..'., .:1".i.:3t,:~._,~... ;:.i,.,.e..W; a._.~:::r;..x ~..::;;s.
'.. ~, , .. ..J::::. . ,..._.....~:.._~...,..._ ."T : ..:.!.'_....
. ,_. ...",., t; :~~,~r'.rr.a._ ..;1 :r i.; ' ._, . , a~:!'r: .
' ...., .... ... .. , _...
_ L .. " _ .. , , ,.~ _....
..... i.~.i1',~'a "; . .:l;:ruJs.~ .~..:... .... i-: Y!) fiY::~ei .
:;..:i<
.....,..
.
a ..
.
..
_ ~v~ g~uz~~s ' ; :' : . ~ ... ~crius9~ioossa B~lCRGR~UND A'~T
Cap and tube assemblies which carry medicines, vitamins, and the like have obtained significant interest , in the pharmaceutical industry. Not only is there a concern for resistance to undesirable tampering, such as by a child, there. is increasing interest in insuring that the entire dose contained in the container is delivered w to the patient and that no parts of the container itself contact the patient.
In my recent patent, U.S. latent No. 4,67,326, I
have provided an excellent design for a child resistant cap. The design described in my patent is of great value in providing a product wherein there is easy inspection of unit dose sterile medicaments in a cap and tube assembly which is child resistant and suitable for a high reliability pass/fail inspection.
Depending upon the size of the tube, the thickness of the thin wall, and the shape of the piercer, tearing the plastic thin wall causes pieces to~break off. These small pieces of plastic are inert, and normally axe not harmful. Howevex, particularly when the contents are eye drops, it would be of great advantage if the possibility of small pieces of plastic breaking. off could be reduced WdD 91/12198 PC~'/US91/~851 ..
::- ;.. v'~.;.'~;
to the absolute minimum, if not totally eliminated.
Accordingly, that is one of the objects of the present invention.
Also, the junction between °the tube and the portion of the tubs which forms the discharge structure for a cap and 'tube assembly often times includes a sharp junction, as would necessarily happen if the discharge nozzle was merely joined to the tube using conventional technology.
In this case, sometimes when the product is dispensed from the tube, one or two drops are :trapped on what becomes a ledge or ring at the junction between the tube and the discharge nozzle. When it is important that the entire dose be received by the user, failure to remove these one or two drops:.provides a:less.-than: complete treatment o - Accordingly, .. it : ~ is aazother ob j ect of .~ this invention to . provide ; ~ design wha.ch allows ~ for total evacuation of '~th~ -tube. ~ . .. . ...:
, . . -~ : - :~:; :. > . ... :; , -: :~: ..: ::.;::
.-..~ . . _..:r.Tn order-to.-increase=the .efficiency of: cap.and_tube -a='.~ assemblies ~~ dining-.ahe ~:~-filling '~step;vi~:particularly -rwhen ~~ automated assembly is -'~ employed, its°=::is-' necessary to rapidly transfer larg~~~r.~'quantities w=of :~ :°cap.::-and ~ tube assemblies to the filling. machine. This is best accomplished by stacking a plurality of assemblies, with ViYO 91/12198 PCTJU691/00851 the assembled cap and tube being sized to fit inside other unfilled cap and tube assemblies. It is also necessary that these stacked assemblies be readily separable with a minimum amount of force, such as in a .
gravity feed ~so that the automated assembly equipment does not become jammed or otherwise malfunctioned. When this stacking feature is contemplated, it is necessary, of course, to size the cap portion so that it fits within the interior~of the adjacent tube. Similarly, the cap cannot be so small that it fits into the nozzle.
Accordingly, it object of .this invention to provide a cap and tube assembly which is suitable for stacking.
When the junction between the tube and the discharge nozzle is a conventional. junction, such as when the tube..and nozzle are merely.joined together, the ring , .~or r ridge-::.which is formed at 'that -~ junction . has the .potential-:.for the cap becoming stuck in that_.junction, thereby causing a difficulty in the_separationof two stacked assemblies. If the cap strikes the junction .....:: between : the ~~tube -sand a nozzle : at an angle,-. there is the .c-,,:Y-,very::,real ~ danger ;:.that : the ' cap ~ will , become -wedged ::in the orifiae;~thereby jamming =~. or otherwise delaying :; the ~.; :~::: operationvof-cassembly. ~equipmen~t. _._. .. .;.: . ... . .
25:~c~ :.~ _. ~. ~. . ,........... , s .; . .. :v ~:-i', ~. ~ -:~..~;:;:~~....
~ .. : , ,!.":.6>~ , :: ~ . ::7:. ., ,, ~~- :, '' :.~> .: . , vl ,. . . ., ._ , _,.. _ , .," . ...
1%~~ 91/12198 ,..r... PC~'/LJS91/00851 1~~,'6~~~~~'~
DT CL~SDRE ~F T:S>; T~i'l.'TOP7 Tt has now been discovered that the above and other objects of the present invention may .be accomplished in the following manner. Specifically, a cap and tube assembly has been discovered which includes the following components.
First, there is a tube for containing a product. A
nozzle is also included,:having one end.mounted,to one -end of the tube. The nozzle has at its other end a thin wall section which is punctu~able to provide a discharge from the device. The nozzle has a smaller axial cross section than the tube. The function of the tube and nozzle is constructed to:.:define an inclined surface of transition from the larger cross section of the tube to the smaller cross section of the nozzle. The surface will~..~ resemble a.funnel, having an . axial cross section which .-begins with_ ..the .:.larger cross section . of the tube' '~-and decreases :ao ::the smaller cross section.,~f 'the _nozzle -~~= "'_' to 'formvthevinclined :surface of :.transition. =~:This;;surface .:~:r :.of'ritransition-,:will permit=..flow: of:the':contents ~ra'x.thout y °' ?.r:Cwitation, =even s:when::~ahe.fluid=: is.; very ~;.nonwiscous such '., ~-as,- 'for example; eye drops. . ... ~~::- . ,.-. _ . .. .
251 i::~". .. ::~' :'~t::v.;"~:'~,-] ?:-._:'..'T .,a~ '...,.... ...:~..)'.
....,,.' _~ , . ..
n VdU 91/12198 F > : : . ,. PCf/US91/00851 ' . ..
The cap and tube assembly of the present invention includes a cap which has an inside cross section which is sized to engage the nozzle. It also has an outside cross , ;
section which is.less than the inside cross section of the tube, so that the tubes can be stacked on top. of. caps as will be described hereinafter.
The cap has an axially centered puncture means TO which 'is positioned in a first position spaced from the thin wall of the nozzle and is movable to aesecond position to puncture.the thin wall and provide access to the contents therein. The puncture means is preferably one which includes a chisel shaped edged~for forming a hole in the wall w~.thout fragmenting the thin wall of the nozzle: . : v.. .
.. In~ another::embodiment :of.ahe present.: invention, .. . there= ~ is .. provided :: a : means .. pos itioned in the . tube f or ~ preventing ~~ entry of ~: .the .,:.cap into -: he . nozzle when ~ .
3:~ . . ='plural3ay . of .assemblies are 'atacked .on, one -:another . :, This -~wwr:~m~a~sl=is- preferably located.. near the :~unction.:be~ween 'the ,.._. . . tubev-and:~the~nozzleo.:.v~.It:umay~:_comprise ~a.>.plurali~y of stacking ribs attached . o -::ahe _: inclined: ..aurfaGe of . , transition, to prevent the cap,from engaging the nozzl~.°
d!'~ 91/1219 PGT/US91/00851 BRIEF DESCRIPTI03v1 OF THE DR~~IY1~1C~S
These and other objects of the present invention and the various features and details of the operation and construction thereof are hereinafter more fully set forth with reference to the accompanying drawings, where:
Fig. 1 is a perspective view of a tubular-plastic medicament container having a cylindrical closure member with an internal axially aligned piercing member, shown as having an open-terminal end prior to filling with a medicament, all in accordance with the, invention.
Fig. 2 is an enlarged, exploded sectional elevational view of the.assembly_shown in Fig. 1.
Fig: 3 is a.secti.onal-view taken:.along the line 3,3 ... of Fig. 2, .showing ,additional details of the .piercing a w: point . . . _ . :-: . .: : ~: . -.
..~.~:: ..., ;:.~ .. .:. :: ~..~:.. :. a;.~M. . .:... :.-: :-:; ~ : .' ~ ::: :
.;~: ;
._. ..... :_Fig: : 4 is a.: plan view: of the cont~iner,;~tak~n;along line 4,4 of the Fig. 2, showing additional details of.the s:s :discharge port ::and.-.diaphragm.r ::~~:e ~._~ : . " .. _ »... ~~~~..=:stu ~.~, .w.c: , . .... .
~'iO 91/12198 , PC,'T/1JS91 /00851 y:...,, i ~ ~.. ~o ~ ~..
~ r~'r~~~
Fig. 5 is a section view, taken along line 5,5 of Fig. 2 showing additional details of the.three triangular i shaped stacking ribs.
..
Fig, 5 is an enlarged fragmentary sectional elevational view taken along lines 6,6 of Fig. 1, showing details of the assembled medicament container and cylindrical member, in an interlock storage mode Fig. 7 is a view similar to Fig. 6, but showing the outer closure member moved forcefully downward, upon the neck portion of the medicant container, driving the piercing point through the diaphragm, creating an opening through which medicament may be divcpensed..
.. ..- Fig; - $ ..,is,,.. a ;.greatly -enlarged> view of . the detail -~ contained ~rithin the dot 'and- dash _circle of Fig;: 7, and designated Fig. $, showing the piercing having. cut through the diaphragm but due to the design of the point . . -e-'creating=a ;flap=which is retained °-by. the container neck.
~,:.~ ; . ~ ... :-.~ta : f~~c.~_. ,.. . . ~~: ' ;~ f :: . . . ~-5~:° -Fig. 9 shows the unfilled medicament assemblies in a stacked, non~~amming mode.
W~ 91/121913 p(°T/~JS91/t10~51 ' ~~'~ ~~~~J
Fig. ZO is perspective view of the medicament ...
assembly shown in Figs. 1 - 9, after being filled with medicament and having its lower terminal end flattened and heat sealed.
V6V0 ~91/1219~ . , ..., ..., , F(.'f/L1S91/00~51,:
. . ~ , (' ,., , URST ?iODE FOR r.~.RRYIIdGOUT °iT~ IIrTVENTIOFd The device of this invention shown generally by the reference numeral 10 includes a tube portion 11 which has , 5 a nozzle 13 at one end thereof, which is joined to the tube via a junction 15. Fitted on the nozzle 13 is a cap 17 .
Shown in greater detail in Fig. 2 is the tube 11 10 and nozzle 13. The nozzle 13 has an axial cross section which is smaller than the axial cross section of the tube 11 such 'that the junction 15 of the nozzle 13 and the tube 11 defines an inclined :surface of transition 16 which permits flow of product from the tube 11 to the nozzle 13 without cavitation or other turbulence.
The other end 19 of nozzle 13 includes a recess 21 protecting a thin wall portion 23 which functions as a diaphragm. The thin wall 23 maintains the sterility and the integrity of the contents .until the thin wall or diaphragm 23 is broken as will be described hereinafter.
The inside wall. 24 adjacent the diaphragm 23 is tapered to facilitate total discharge of the contents in the same way that surface of transition 16 functions. ' , '1~U0 91/12198 PC'f/LJS91/00851 ' Nozzle 13 also contains a rib 25 on the outside thereof for positioning the cap as will be described hereinafter. Also shown in Fig. 2 and in Fig. 5 is a stacking rib 27 which may be formed in three parts, shown as 27a, 27b; and 27c respectivelys The cap 17 has a elosed end 29 with an interior wall 31. Mounted on the interior wall -3l is a piercer point-33 which serves to puncture the diaphragm 23 when . access:.ta the contents is desired..
The cap 17 also includes ~ groove 35 located on the.
inside wall of the cap and sized:to interlock with the ' 15 ring 25 and provide a means for :Fixedly locating the cap 17 .. with . respect to the tube . 11..:..:. It is, : of .caurse, vpossible:to :reverse .these two elements ~so that. the ring or rib~25 would be on.;the :inside of: cap 17,_..:and the groove 35 would be in~the nozzla~l3a. The:ring and groove serve :.asv::-a.._.surface of._ resistance:.:and :.an-v ~.nterference surface which cooperate to restrain movement of the cap .::v,~c on the'wozzle: ~.-:~- . _ .:( a ~..~~ .
;.,r......... . _.,t.: _.... .:;ue:..~',~~ - . . . ..: i~~'~,: .:r.!''.!e ,..
~ _..._ ,._..~::.r:3'. .
.. ... v Finally s=: .its :is~~noted~:,that~vthe piercing~:.point 33 ::-.:25 .;~..~referabl~'a.has a ,chisel..: shape in order-..to~~form~ ~ :hole:
in -.i~~ ~~the -diaphragm 23 'without fragmenting ahe ,_thin :;wall 23.
WCl 91/12198 , PCT/t1~91/00851 ':;, 5.~~ s . . . , ~_'_:~/,~ , ~,~'~~ ~~~
As shown in Fig. 6, the cap 17 is located on the nozzle 13 by the interlocking of the rib 25 and the groove 35. When the cap i7 is fired in this location, the piercing.point 33 does not reach to the diaphragm 23, thereby preserving the integrity of the contents. In order to obtain access to the contents, pressure is applied to the cap 17 in the direction of arrow 39 so that the chiseled shape 37 of the piercer point 33 passes through the diaphragm 23 and causes a portion 23a to peel back and provide access to the contents .when the cap 17 is removed.
If all of the contents tube 11 have not been removed, the cap.l7.can be. replaced such as by relocating the ring 25 and groove 35. .In.:order to prevent the contents:from::escaping the tube altogether, the.cap 17 can ~be repositioned :.as shown in Figs: 7: and 8, - so that - the piercing point . 33 -serves'. as a. plug for :the hole :20.::.created.by peeled.portion 23a of;the diaphragm.23.. >
. ~ ~. . ;: . ,..i ~ ., . .~,. .. ., . .-:.,f . :. n ..
3~ypically, however, the present~.,degign :is most suitable fox a unit dose application. For this reason, _ _ .:..the ~.yunction :15: defines ~ anv:inclined surface of transition ...: 25 ~:~16.. to permit°vflow ,of the.-tcontents .without-,~cavitation ::from .
-.: the'>tube;;ll_:to°_the~°nozzle 13: W:Tnside ,wall~,24serves the ,. ~'~ 91/12198 ~~~ ~~~,~ PCT/ZJ591/00851 same purpose. Once the contents have been expelled, the cap can be replaced on the nozzle, engaging ring 25 in groove 35 until the entire assembly can be disposed of properly.
nuring the assembly process, it may be desirable to stack a plurality of assemblies, particularly when there is automated equipment in use. shown in Fig. 9 is a tube 11 and cap 17 positioned within the tube lla of a second assembly. dote that the stacking ribs 27a and 27c prevent the cap .17 from entering the opening to nozzle 13a. The advantage of this construction is that the assemblies do not become stuck to one another when stacked and they can be easily removed for filling, labeling or other assembly operations. The depth of the ring 25 and groove 35 is sufficient to prevent movement of the cap 17 with respect to the nozzle 13 during this assembly process.
The final step in the assembly of the device of this invention is shown in Fig. 10, where. the other end of tube 11 has been flattened and heat sealed at 41.
Thus, the entire contents are protected and sterile conditions are preserved until the time when the medicament is needed.
i W~ 91/12198 w Pd.'T/IJS91l00851 ~~'>.' While particular embodiments of the invention have -been illustrated and described herein,_it is not intended to limit the invention, and changes and modifications anay , be made herein~within the scope of the following claims.
,-w_... . ..
:, _, . .. : . . . ., . . ~ .~ ~. . .. . , .: ... .. .. .. . . ~s c~:'n ., ~~w'-> ~. r, ..a :_ . . _. :, ._._~ :~ _. . _ . ~.~ .. , .... _. _ . .. . ~ .
... ::.s .. .~, _... . . , . . ' ;~ .. . . _. , . .......: .7.;_:., .~ :::o:J.~ .. ' -_ =:~'< ::.~ 4 : , ...~ ., '~~. r~
. . .. ...~ .. __....., i_9-_~....:.i.~::.~~.~'yi .. ::.i w..i.,.t:..~i~.. .
_...w~~~'v3. '...,. , ._ ~~',: ' ~.r~_;' .<-,. _.>.. _.... .... ~! , i:'.'. .. ... " i.'::;,' .... !..;.:.....
_.
.. ..~~.: ,..- .. . 1::~~ 4 s).. ~:~ ...
d!'~ 91/1219 PGT/US91/00851 BRIEF DESCRIPTI03v1 OF THE DR~~IY1~1C~S
These and other objects of the present invention and the various features and details of the operation and construction thereof are hereinafter more fully set forth with reference to the accompanying drawings, where:
Fig. 1 is a perspective view of a tubular-plastic medicament container having a cylindrical closure member with an internal axially aligned piercing member, shown as having an open-terminal end prior to filling with a medicament, all in accordance with the, invention.
Fig. 2 is an enlarged, exploded sectional elevational view of the.assembly_shown in Fig. 1.
Fig: 3 is a.secti.onal-view taken:.along the line 3,3 ... of Fig. 2, .showing ,additional details of the .piercing a w: point . . . _ . :-: . .: : ~: . -.
..~.~:: ..., ;:.~ .. .:. :: ~..~:.. :. a;.~M. . .:... :.-: :-:; ~ : .' ~ ::: :
.;~: ;
._. ..... :_Fig: : 4 is a.: plan view: of the cont~iner,;~tak~n;along line 4,4 of the Fig. 2, showing additional details of.the s:s :discharge port ::and.-.diaphragm.r ::~~:e ~._~ : . " .. _ »... ~~~~..=:stu ~.~, .w.c: , . .... .
~'iO 91/12198 , PC,'T/1JS91 /00851 y:...,, i ~ ~.. ~o ~ ~..
~ r~'r~~~
Fig. 5 is a section view, taken along line 5,5 of Fig. 2 showing additional details of the.three triangular i shaped stacking ribs.
..
Fig, 5 is an enlarged fragmentary sectional elevational view taken along lines 6,6 of Fig. 1, showing details of the assembled medicament container and cylindrical member, in an interlock storage mode Fig. 7 is a view similar to Fig. 6, but showing the outer closure member moved forcefully downward, upon the neck portion of the medicant container, driving the piercing point through the diaphragm, creating an opening through which medicament may be divcpensed..
.. ..- Fig; - $ ..,is,,.. a ;.greatly -enlarged> view of . the detail -~ contained ~rithin the dot 'and- dash _circle of Fig;: 7, and designated Fig. $, showing the piercing having. cut through the diaphragm but due to the design of the point . . -e-'creating=a ;flap=which is retained °-by. the container neck.
~,:.~ ; . ~ ... :-.~ta : f~~c.~_. ,.. . . ~~: ' ;~ f :: . . . ~-5~:° -Fig. 9 shows the unfilled medicament assemblies in a stacked, non~~amming mode.
W~ 91/121913 p(°T/~JS91/t10~51 ' ~~'~ ~~~~J
Fig. ZO is perspective view of the medicament ...
assembly shown in Figs. 1 - 9, after being filled with medicament and having its lower terminal end flattened and heat sealed.
V6V0 ~91/1219~ . , ..., ..., , F(.'f/L1S91/00~51,:
. . ~ , (' ,., , URST ?iODE FOR r.~.RRYIIdGOUT °iT~ IIrTVENTIOFd The device of this invention shown generally by the reference numeral 10 includes a tube portion 11 which has , 5 a nozzle 13 at one end thereof, which is joined to the tube via a junction 15. Fitted on the nozzle 13 is a cap 17 .
Shown in greater detail in Fig. 2 is the tube 11 10 and nozzle 13. The nozzle 13 has an axial cross section which is smaller than the axial cross section of the tube 11 such 'that the junction 15 of the nozzle 13 and the tube 11 defines an inclined :surface of transition 16 which permits flow of product from the tube 11 to the nozzle 13 without cavitation or other turbulence.
The other end 19 of nozzle 13 includes a recess 21 protecting a thin wall portion 23 which functions as a diaphragm. The thin wall 23 maintains the sterility and the integrity of the contents .until the thin wall or diaphragm 23 is broken as will be described hereinafter.
The inside wall. 24 adjacent the diaphragm 23 is tapered to facilitate total discharge of the contents in the same way that surface of transition 16 functions. ' , '1~U0 91/12198 PC'f/LJS91/00851 ' Nozzle 13 also contains a rib 25 on the outside thereof for positioning the cap as will be described hereinafter. Also shown in Fig. 2 and in Fig. 5 is a stacking rib 27 which may be formed in three parts, shown as 27a, 27b; and 27c respectivelys The cap 17 has a elosed end 29 with an interior wall 31. Mounted on the interior wall -3l is a piercer point-33 which serves to puncture the diaphragm 23 when . access:.ta the contents is desired..
The cap 17 also includes ~ groove 35 located on the.
inside wall of the cap and sized:to interlock with the ' 15 ring 25 and provide a means for :Fixedly locating the cap 17 .. with . respect to the tube . 11..:..:. It is, : of .caurse, vpossible:to :reverse .these two elements ~so that. the ring or rib~25 would be on.;the :inside of: cap 17,_..:and the groove 35 would be in~the nozzla~l3a. The:ring and groove serve :.asv::-a.._.surface of._ resistance:.:and :.an-v ~.nterference surface which cooperate to restrain movement of the cap .::v,~c on the'wozzle: ~.-:~- . _ .:( a ~..~~ .
;.,r......... . _.,t.: _.... .:;ue:..~',~~ - . . . ..: i~~'~,: .:r.!''.!e ,..
~ _..._ ,._..~::.r:3'. .
.. ... v Finally s=: .its :is~~noted~:,that~vthe piercing~:.point 33 ::-.:25 .;~..~referabl~'a.has a ,chisel..: shape in order-..to~~form~ ~ :hole:
in -.i~~ ~~the -diaphragm 23 'without fragmenting ahe ,_thin :;wall 23.
WCl 91/12198 , PCT/t1~91/00851 ':;, 5.~~ s . . . , ~_'_:~/,~ , ~,~'~~ ~~~
As shown in Fig. 6, the cap 17 is located on the nozzle 13 by the interlocking of the rib 25 and the groove 35. When the cap i7 is fired in this location, the piercing.point 33 does not reach to the diaphragm 23, thereby preserving the integrity of the contents. In order to obtain access to the contents, pressure is applied to the cap 17 in the direction of arrow 39 so that the chiseled shape 37 of the piercer point 33 passes through the diaphragm 23 and causes a portion 23a to peel back and provide access to the contents .when the cap 17 is removed.
If all of the contents tube 11 have not been removed, the cap.l7.can be. replaced such as by relocating the ring 25 and groove 35. .In.:order to prevent the contents:from::escaping the tube altogether, the.cap 17 can ~be repositioned :.as shown in Figs: 7: and 8, - so that - the piercing point . 33 -serves'. as a. plug for :the hole :20.::.created.by peeled.portion 23a of;the diaphragm.23.. >
. ~ ~. . ;: . ,..i ~ ., . .~,. .. ., . .-:.,f . :. n ..
3~ypically, however, the present~.,degign :is most suitable fox a unit dose application. For this reason, _ _ .:..the ~.yunction :15: defines ~ anv:inclined surface of transition ...: 25 ~:~16.. to permit°vflow ,of the.-tcontents .without-,~cavitation ::from .
-.: the'>tube;;ll_:to°_the~°nozzle 13: W:Tnside ,wall~,24serves the ,. ~'~ 91/12198 ~~~ ~~~,~ PCT/ZJ591/00851 same purpose. Once the contents have been expelled, the cap can be replaced on the nozzle, engaging ring 25 in groove 35 until the entire assembly can be disposed of properly.
nuring the assembly process, it may be desirable to stack a plurality of assemblies, particularly when there is automated equipment in use. shown in Fig. 9 is a tube 11 and cap 17 positioned within the tube lla of a second assembly. dote that the stacking ribs 27a and 27c prevent the cap .17 from entering the opening to nozzle 13a. The advantage of this construction is that the assemblies do not become stuck to one another when stacked and they can be easily removed for filling, labeling or other assembly operations. The depth of the ring 25 and groove 35 is sufficient to prevent movement of the cap 17 with respect to the nozzle 13 during this assembly process.
The final step in the assembly of the device of this invention is shown in Fig. 10, where. the other end of tube 11 has been flattened and heat sealed at 41.
Thus, the entire contents are protected and sterile conditions are preserved until the time when the medicament is needed.
i W~ 91/12198 w Pd.'T/IJS91l00851 ~~'>.' While particular embodiments of the invention have -been illustrated and described herein,_it is not intended to limit the invention, and changes and modifications anay , be made herein~within the scope of the following claims.
,-w_... . ..
:, _, . .. : . . . ., . . ~ .~ ~. . .. . , .: ... .. .. .. . . ~s c~:'n ., ~~w'-> ~. r, ..a :_ . . _. :, ._._~ :~ _. . _ . ~.~ .. , .... _. _ . .. . ~ .
... ::.s .. .~, _... . . , . . ' ;~ .. . . _. , . .......: .7.;_:., .~ :::o:J.~ .. ' -_ =:~'< ::.~ 4 : , ...~ ., '~~. r~
. . .. ...~ .. __....., i_9-_~....:.i.~::.~~.~'yi .. ::.i w..i.,.t:..~i~.. .
_...w~~~'v3. '...,. , ._ ~~',: ' ~.r~_;' .<-,. _.>.. _.... .... ~! , i:'.'. .. ... " i.'::;,' .... !..;.:.....
_.
.. ..~~.: ,..- .. . 1::~~ 4 s).. ~:~ ...
Claims (3)
1. A cap and tube assembly device, comprising:
a tube for containing a product;
a nozzle having one end mounted to one end of said tube and having a thin wall section puncturable to provide a discharge on the other end;
said nozzle having a non-threaded outer nozzle surface with a smaller axial cross section than said tube, the junction of said tube and said nozzle defining an inclined surface of transition to permit flow without cavitation from said tube to said nozzle;
a cap having an inside non-threaded cap surface with a cross section sized to slidably engage said nozzle and having an outside cross section less than the inside cross section of said tube;
said cap having an axially centered puncture means positioned in a first position spaced from said thin wall and movable to a second position to puncture said thin wall said nozzle surface and cap surface mating to locate said first position;
wherein the outside of said nozzle is provided with a surface of resistance and the inside of said cap has an interference surface, whereby said surface of resistance and said interference surface cooperate to selectively maintain said puncture means in said first position;
said puncture means having a chisel shaped edge for forming an axially centered hole in said wall without removing or fragmenting said wall; and means positioned in said tube including a plurality of stacking ribs attached to said inclined surface of transition for preventing entry of said cap into said nozzle when a plurality of said assemblies are stacked one on another.
a tube for containing a product;
a nozzle having one end mounted to one end of said tube and having a thin wall section puncturable to provide a discharge on the other end;
said nozzle having a non-threaded outer nozzle surface with a smaller axial cross section than said tube, the junction of said tube and said nozzle defining an inclined surface of transition to permit flow without cavitation from said tube to said nozzle;
a cap having an inside non-threaded cap surface with a cross section sized to slidably engage said nozzle and having an outside cross section less than the inside cross section of said tube;
said cap having an axially centered puncture means positioned in a first position spaced from said thin wall and movable to a second position to puncture said thin wall said nozzle surface and cap surface mating to locate said first position;
wherein the outside of said nozzle is provided with a surface of resistance and the inside of said cap has an interference surface, whereby said surface of resistance and said interference surface cooperate to selectively maintain said puncture means in said first position;
said puncture means having a chisel shaped edge for forming an axially centered hole in said wall without removing or fragmenting said wall; and means positioned in said tube including a plurality of stacking ribs attached to said inclined surface of transition for preventing entry of said cap into said nozzle when a plurality of said assemblies are stacked one on another.
2. The device of claim 1 wherein said surface of resistance and said interference surface comprise mutually aligned tapered surfaces on the outside of said nozzle and the inside of said cap to provide a snug fit at said first position, said cap being expandable upon movement to said second position.
3. The device of claim 1 wherein said surface of transition is at approximately 45° with respect to the axis of the nozzle and tube.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US476,839 | 1990-02-08 | ||
| US07/476,839 US5052589A (en) | 1990-02-08 | 1990-02-08 | Unit dose assembly |
| PCT/US1991/000851 WO1991012198A1 (en) | 1990-02-08 | 1991-02-07 | Unit dose assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2075500A1 CA2075500A1 (en) | 1991-08-09 |
| CA2075500C true CA2075500C (en) | 2000-12-19 |
Family
ID=23893467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002075500A Expired - Lifetime CA2075500C (en) | 1990-02-08 | 1991-02-07 | Unit dose assembly |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5052589A (en) |
| EP (1) | EP0513229B1 (en) |
| JP (1) | JPH05506000A (en) |
| BR (1) | BR9105996A (en) |
| CA (1) | CA2075500C (en) |
| DE (1) | DE69108382T2 (en) |
| FI (1) | FI103379B1 (en) |
| WO (1) | WO1991012198A1 (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0752040Y2 (en) * | 1991-04-06 | 1995-11-29 | 東亞合成株式会社 | Adhesive container |
| US5226562A (en) * | 1991-09-11 | 1993-07-13 | Norbert Kirk | Dispenser for glue cartridge |
| AU2889592A (en) * | 1991-10-24 | 1993-05-21 | Cp Packaging, Inc. | Container closure assemblies |
| US5301837A (en) * | 1992-01-31 | 1994-04-12 | Cp Packaging, Inc. | Child resistant medicament dispenser |
| GB9125699D0 (en) * | 1991-12-03 | 1992-01-29 | Glaxo Group Ltd | Device |
| CH684082A5 (en) * | 1991-12-19 | 1994-07-15 | Sika Robotics Ag | Container. |
| JPH0749308B2 (en) * | 1992-04-14 | 1995-05-31 | 積水アイコー株式会社 | One push squeeze type double structure type adhesive packaging container |
| GB9311892D0 (en) * | 1993-06-09 | 1993-07-28 | Glaxo Wellcome Australia Ltd | Device |
| US5469980A (en) * | 1994-01-26 | 1995-11-28 | Wheaton Holding, Inc. | Child resistant container closure assembly |
| US5464122A (en) * | 1994-06-24 | 1995-11-07 | Merck & Co., Inc. | Non-streaming ophthalmic tip and delivery device |
| US6379069B1 (en) | 1994-12-12 | 2002-04-30 | James Alexander Corporation | Dispenser and process |
| US5582330A (en) * | 1994-12-28 | 1996-12-10 | Allergan, Inc. | Specific volume dispenser |
| WO1996038346A1 (en) * | 1995-05-29 | 1996-12-05 | Pentel Kabushiki Kaisha | Liquid container |
| US5590780A (en) * | 1995-06-22 | 1997-01-07 | Wheaton Holding, Inc. | Unit dose assembly |
| CA2223249C (en) * | 1995-06-22 | 2007-12-18 | Wheaton Holding, Inc. | Container-closure assembly |
| DE19628384C2 (en) * | 1996-07-13 | 1998-10-22 | Kerplas Neuenburg Gmbh Kunstst | Container with a plastic outlet cannula that can be closed by a cap |
| US6126037A (en) * | 1997-09-09 | 2000-10-03 | Merck & Co., Inc. | Flow control orifice |
| GB2328935A (en) * | 1997-09-09 | 1999-03-10 | Merck & Co Inc | Method for producing a uniform flow control orifice |
| ES2191420T3 (en) * | 1998-03-05 | 2003-09-01 | Henkel Kgaa | PACK WITH A DISCHARGE NOZZLE. |
| US20040127861A1 (en) * | 2002-12-26 | 2004-07-01 | Bradley Pharmaceuticals, Inc. | Method and apparatus for dispensing a composition |
| ITMO20030283A1 (en) * | 2003-10-21 | 2005-04-22 | Lameplast Spa | BOTTLE FOR FLUID PRODUCTS, PARTICULARLY PHARMACEUTICAL, |
| US7581899B2 (en) | 2004-11-30 | 2009-09-01 | James Alexander Corporation | Dispenser and process |
| JP4045277B2 (en) * | 2005-01-17 | 2008-02-13 | 株式会社ファンケル | Bottle container |
| US7976234B2 (en) * | 2006-04-28 | 2011-07-12 | James Alexander Corporation | Multi-chambered dispenser and process |
| US7591398B2 (en) * | 2006-09-27 | 2009-09-22 | Pouchsmart, Inc. | Container closure assembly |
| US8109236B2 (en) * | 2007-04-05 | 2012-02-07 | Sumitomo Corporation Of America | Fluid delivery assembly |
| US8668400B2 (en) * | 2007-04-05 | 2014-03-11 | The Hartz Mountain Corporation | Fluid applicator |
| US7665474B2 (en) * | 2007-06-06 | 2010-02-23 | Virginia Morales | Disposable eyebrow dye kit |
| US8910830B2 (en) | 2007-12-18 | 2014-12-16 | James Alexander Corporation | Container assembly |
| US8403178B2 (en) * | 2007-12-18 | 2013-03-26 | James Alexander Corporation | Container assembly |
| US8100294B2 (en) * | 2007-12-18 | 2012-01-24 | James Alexander Corporation | Container assembly |
| ATE548285T1 (en) | 2008-01-29 | 2012-03-15 | James Alexander Corp | DONOR |
| US9567138B2 (en) * | 2011-05-24 | 2017-02-14 | Sunstar Americas, Inc. | Delivery system |
| JP2013224160A (en) * | 2012-04-20 | 2013-10-31 | Kokuyo S&T Co Ltd | Container |
| JP6029001B2 (en) * | 2012-10-31 | 2016-11-24 | 株式会社吉野工業所 | Container with nozzle cap |
| FR3110898B1 (en) * | 2020-05-27 | 2024-03-15 | Coradin Sas | ASSEMBLY COMPOSED OF A CONTAINER FOR A FLUID AND A DISPENSER PACKAGING |
| US11772851B2 (en) * | 2021-06-21 | 2023-10-03 | Medmix Switzerland Ag | Liquid applicator |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2771218A (en) * | 1954-05-19 | 1956-11-20 | Henderson Edward | Closure assembly |
| US3454196A (en) * | 1967-07-20 | 1969-07-08 | Polytop Corp | Fixed spout closure with auxiliary cap |
| US3580423A (en) * | 1969-02-27 | 1971-05-25 | Realistic Co | Container closure and apparatus for opening same |
| US3922099A (en) * | 1974-06-26 | 1975-11-25 | William C Christine | Applicator dispenser |
| US4296786A (en) * | 1979-09-28 | 1981-10-27 | The West Company | Transfer device for use in mixing a primary solution and a secondary or additive substance |
| US4723687A (en) * | 1981-03-16 | 1988-02-09 | Franz Kutterer | Tube with screw cap |
| US4493439A (en) * | 1981-07-20 | 1985-01-15 | William Ledewitz | Collapsible dispensing container |
| US4681243A (en) * | 1984-03-07 | 1987-07-21 | Colpo Co., Ltd. | Cartridge with plug opening mechanism |
| US4867326A (en) * | 1988-08-25 | 1989-09-19 | Cp Packaging | Child resistant cap and tube assembly |
| US4884703A (en) * | 1988-09-27 | 1989-12-05 | Cp Packaging Inc. | Container and closure assembly |
-
1990
- 1990-02-08 US US07/476,839 patent/US5052589A/en not_active Expired - Lifetime
-
1991
- 1991-02-07 BR BR919105996A patent/BR9105996A/en not_active IP Right Cessation
- 1991-02-07 WO PCT/US1991/000851 patent/WO1991012198A1/en active IP Right Grant
- 1991-02-07 JP JP91504696A patent/JPH05506000A/en active Pending
- 1991-02-07 CA CA002075500A patent/CA2075500C/en not_active Expired - Lifetime
- 1991-02-07 EP EP91904891A patent/EP0513229B1/en not_active Expired - Lifetime
- 1991-02-07 DE DE69108382T patent/DE69108382T2/en not_active Expired - Fee Related
-
1992
- 1992-08-10 FI FI923573A patent/FI103379B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05506000A (en) | 1993-09-02 |
| BR9105996A (en) | 1992-11-10 |
| EP0513229A4 (en) | 1993-03-10 |
| FI103379B (en) | 1999-06-30 |
| FI923573A (en) | 1992-08-10 |
| DE69108382T2 (en) | 1995-11-02 |
| WO1991012198A1 (en) | 1991-08-22 |
| CA2075500A1 (en) | 1991-08-09 |
| US5052589A (en) | 1991-10-01 |
| FI923573A0 (en) | 1992-08-10 |
| EP0513229B1 (en) | 1995-03-22 |
| DE69108382D1 (en) | 1995-04-27 |
| EP0513229A1 (en) | 1992-11-19 |
| FI103379B1 (en) | 1999-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2075500C (en) | Unit dose assembly | |
| CA1331363C (en) | Child resistant cap and tube assembly | |
| US6387073B1 (en) | Hermetically sealed container with medicament storing and dispensing insert | |
| EP1814794B1 (en) | Multi-chamber container and cap therefor | |
| US6921383B2 (en) | Tamper evident end cap assembly for a loaded syringe and process | |
| JP5576128B2 (en) | Material release spout | |
| EP2070840A2 (en) | Container with pill dispensing insert | |
| BRPI0806474A2 (en) | intranasal cartridge devices | |
| JP2008502422A (en) | Tamper-evident overcap for containers | |
| PL205227B1 (en) | Sliding reconstitution device for a diluent container | |
| US20140209603A1 (en) | Stopping device and container comprising such a device | |
| US20120216909A1 (en) | Dosing Adapter for Use with Oral Syringe | |
| KR102268214B1 (en) | Dispensing device having a peripheral outer wall | |
| US6983843B2 (en) | Container and a container accessory | |
| WO2003011705A1 (en) | Flip top piercing tip cap | |
| US4586622A (en) | Tamper-resistant pharmaceutical vial and cap assembly | |
| EP2616354B1 (en) | Closing device for a container and container comprising said closing device | |
| AU2002253786A1 (en) | A container and a container accessory | |
| US11180296B2 (en) | Doser cap for liquid container | |
| EP2137080B1 (en) | A dispensing device | |
| CA2121695A1 (en) | Container closure assemblies | |
| AU2017208698A1 (en) | Closure for a container | |
| BRPI0806080A2 (en) | membrane piercing twist closure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |