CA2093895A1 - Nail lacquer for the treatment of onychomycosis - Google Patents

Nail lacquer for the treatment of onychomycosis

Info

Publication number
CA2093895A1
CA2093895A1 CA2093895A CA2093895A CA2093895A1 CA 2093895 A1 CA2093895 A1 CA 2093895A1 CA 2093895 A CA2093895 A CA 2093895A CA 2093895 A CA2093895 A CA 2093895A CA 2093895 A1 CA2093895 A1 CA 2093895A1
Authority
CA
Canada
Prior art keywords
lacquer
urea
onychomycosis
treatment
nail lacquer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2093895A
Other languages
French (fr)
Other versions
CA2093895C (en
Inventor
Wolfgang Wohlrab
Katrin Wellner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dermapharm AG
Original Assignee
Roehm GmbH Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm GmbH Chemische Fabrik filed Critical Roehm GmbH Chemische Fabrik
Publication of CA2093895A1 publication Critical patent/CA2093895A1/en
Application granted granted Critical
Publication of CA2093895C publication Critical patent/CA2093895C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a nail lacquer for treating onychomycosis, comprised of a film-forming agent, an antimycotically active substance, and urea, wherewith the antimycotically active substance and the urea are liberated from the lacquer when the lacquer is applied.
A preferred formulation comprises cellulose derivative(s) as film former(s), clotrimazole as the antimycotic (present in the amount of 5-30 wt.% based on the weight of the non-volatile components), urea (present in the amount of 15-60 wt.% based on the weight of the non-volatile components), and dibutyl phthalate as a plasticizer, in a solvent mixture comprised of acetone and ethanol.
CA002093895A 1992-04-10 1993-04-13 Nail lacquer for the treatment of onychomycosis Expired - Fee Related CA2093895C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4212105.1 1992-04-10
DE4212105A DE4212105A1 (en) 1992-04-10 1992-04-10 Nail polish for the treatment of onychomycoses

Publications (2)

Publication Number Publication Date
CA2093895A1 true CA2093895A1 (en) 1993-10-11
CA2093895C CA2093895C (en) 1997-04-15

Family

ID=6456565

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093895A Expired - Fee Related CA2093895C (en) 1992-04-10 1993-04-13 Nail lacquer for the treatment of onychomycosis

Country Status (6)

Country Link
US (1) US5346692A (en)
EP (1) EP0565072B1 (en)
JP (1) JPH069342A (en)
AT (1) ATE150641T1 (en)
CA (1) CA2093895C (en)
DE (2) DE4212105A1 (en)

Families Citing this family (62)

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DE19518262A1 (en) * 1995-05-18 1996-11-21 Hoechst Ag The use of glyceryl triacetate for the treatment of onychomycoses
US5661170A (en) * 1994-03-21 1997-08-26 Woodward Laboratories, Inc. Antimicrobial compositions and methods for using the same
US5632973A (en) * 1995-09-19 1997-05-27 Keller; Alexander M. L. Artificial fingernail method and composition
US5770184A (en) * 1995-09-19 1998-06-23 Keller; Alexander M. L. Artificial fingernail method and composition
DE19643831A1 (en) 1996-10-30 1998-05-07 Hoechst Ag Medicament for treating azole-resistant fungal infections
US5696105A (en) * 1996-03-14 1997-12-09 Hackler; Walter A. Antifungal nail composition
US20040039030A1 (en) * 1996-09-27 2004-02-26 Hoechst Akeengesellschaft Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
DE19639816A1 (en) * 1996-09-27 1998-04-02 Hoechst Ag Antifungal agents with high drug release
DE19639817A1 (en) 1996-09-27 1998-04-02 Hoechst Ag Use of 1-hydroxy-2-pyridones for the treatment of skin infections
US5968986A (en) * 1997-12-18 1999-10-19 Woodward Laboratories, Inc. Antimicrobial nail coating composition
CA2298526A1 (en) * 1997-07-28 1999-02-04 Dermatolazer Technologies Ltd Phototherapy based method for treating pathogens and composition for effecting same
US5993790A (en) * 1997-08-04 1999-11-30 Pedinol Pharmacal Inc. Nail evulsion compositions and method for evulsing nails and treating nail and nail bed infections
US5994383A (en) * 1997-11-18 1999-11-30 Woodward Laboratories, Inc. Surfactant-based antimicrobial compositions and methods for using the same
BR9904780A (en) 1998-02-09 2000-03-08 Macrochem Corp Fungicide nail polish and method of using it
US6264927B1 (en) 1998-08-27 2001-07-24 Elmer P. Monahan Topical solution and method for the treatment of nail fungus
US6479039B1 (en) 1999-07-13 2002-11-12 Woodward Laboratories, Inc. Antimicrobial artificial nail composition and methods for preparing and using same
US6403063B1 (en) 1999-07-26 2002-06-11 Kenneth I. Sawyer Method of treating nail fungus
US6401724B1 (en) * 1999-10-11 2002-06-11 Par Pharmaceuticals Incorporated Method of applying a cosmetic nail lacquer or polish to a nail
PT1263426E (en) * 2000-01-03 2006-07-31 Manfred Bohn PREPARATIONS FOR THE TRAUMATIC REMOVAL OF A UNION
US6495124B1 (en) 2000-02-14 2002-12-17 Macrochem Corporation Antifungal nail lacquer and method using same
DE10011081A1 (en) * 2000-03-09 2001-09-13 Aventis Pharma Gmbh Lacquer formulation for treating and preventing onychomycosis, comprising combination of systemic and topical antimycotic agents in film-forming polymer base
US8257688B2 (en) * 2000-03-27 2012-09-04 Taro Pharmaceuticals Industries Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues
US7074392B1 (en) * 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
US6740314B2 (en) 2000-07-07 2004-05-25 Kirker-Enterprises, Inc. Nail enamel compositions containing bismuth oxychloride
US6565835B1 (en) 2000-07-07 2003-05-20 Kirker Enterprises, Inc. Nail enamel compositions containing aluminum platelets
DE10035991A1 (en) * 2000-07-24 2002-02-14 Polichem Sa Nail polish composition
AU2002248308B2 (en) * 2001-01-09 2006-12-07 Israel Dvoretzky Therapeutic film forming composition and treatment system
US6878365B2 (en) * 2001-03-10 2005-04-12 James Edward Brehove Topical application for treating toenail fungus
DE10126501A1 (en) * 2001-05-30 2002-12-12 Aventis Pharma Gmbh Composition used for detaching abnormal keratin material e.g. warts or fungally damage nails, comprises mixture of urea, film former and water or aqueous alcohol
FR2830449B1 (en) * 2001-10-05 2004-04-23 Fabre Pierre Dermo Cosmetique USE OF TAZAROTENE FOR THE PREPARATION OF A NAIL VARNISH FOR THE TREATMENT AND / OR PREVENTION OF PSORIASIS AND A NAIL VARNISH CONTAINING IT
US20040071760A1 (en) * 2002-01-07 2004-04-15 Israel Dvoretzky Therapeutic film forming composition and treatment system therefor
US6998114B2 (en) 2002-01-22 2006-02-14 Eastman Chemical Company Hair grooming formulations and methods for the use thereof
US6743417B2 (en) * 2002-04-22 2004-06-01 Bradley Pharmaceuticals, Inc. Method of treating onychomycosis with urea and an antioxidant
US20030049307A1 (en) * 2002-08-15 2003-03-13 Gyurik Robert J. Pharmaceutical composition
US20060216267A1 (en) * 2002-08-20 2006-09-28 Kovacs Stephen G Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
US20050025724A1 (en) * 2003-07-28 2005-02-03 Robert Laggan Composition and method for dry nail polish repair
EP1648378A2 (en) * 2003-07-29 2006-04-26 Pierre Fabre Dermo-Cosmetique Antimycosic nail varnish
DE10341944A1 (en) * 2003-09-11 2005-04-28 York Pharma Plc Antimycotic nail polish formulation with substituted 2-aminothiazoles as active ingredient
WO2007106622A2 (en) * 2006-02-03 2007-09-20 Carl Lawyer Fungicidal formulation and method of use
WO2007098591A2 (en) * 2006-03-02 2007-09-07 Nuvo Research Inc. Topical nail formulation
DE102006049585A1 (en) * 2006-10-22 2008-04-24 Susilo, Rudy, Dr. Nail varnish useful for treating toenail and fingernail disorders comprises urea; fatty acids; allantoin, dexpanthenol, hyaluronic acid, penetration enhancer, antimicrobial agent, antipsoriatic agent and/or antieczema agent
US8771725B2 (en) 2007-10-12 2014-07-08 Chesson Laboratory Associates, Inc. Poly(urea-urethane) compositions useful as topical medicaments and methods of using the same
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US20090298805A1 (en) * 2008-06-03 2009-12-03 Polson George A Topical pyrithione compositions and methods for treatment of nail fungus
FR2937250B1 (en) * 2008-10-21 2013-05-10 Fabre Pierre Dermo Cosmetique UREA-BASED FILMOGENOUS SOLUTION FOR THE TREATMENT OF NAIL PSORASIS
MX2012001766A (en) * 2009-08-13 2012-03-07 Moberg Derma Ab Compositions and methods for treating fungal infection of the nail.
ES2369101B2 (en) 2010-05-07 2012-08-02 Universidade De Santiago De Compostela PHARMACEUTICAL SYSTEM FOR THE ADMINISTRATION OF DRUGS IN THE NAILS.
WO2012110430A1 (en) * 2011-02-10 2012-08-23 Moberg Derma Ab Novel composition for topical use on a nail
US9295251B1 (en) 2011-04-08 2016-03-29 Safehands Solutions, LLC Synergistic antimicrobial compositions of PCMX and carboxylic acid and related methods
US9693564B2 (en) 2011-06-21 2017-07-04 Safehands Solutions, LLC Water based antimicrobial composition using benzalkonium chloride and cocamidopropyl PG-dimonium chloride phosphate
CA2775393C (en) * 2012-05-02 2014-04-29 Samy Saad Topical non-aqueous pharmaceutical formulations
US8835369B2 (en) 2012-06-04 2014-09-16 L'oreal Odorless acetone-free nail polish removing composition
NL2009669C2 (en) * 2012-10-19 2014-04-23 Dutch Renewable Energy B V Enhanced nail penetrating composition.
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
EP2968886A1 (en) 2013-03-14 2016-01-20 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
MX363386B (en) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Stabilized efinaconazole compositions.
EP3091985A4 (en) 2014-01-10 2017-11-29 Manistee Partners LLC Treatment of migraines
EP2952208A1 (en) 2014-06-04 2015-12-09 Universidade de Santiago de Compostela Hydroalcoholic system for nail treatment
ITUA20164000A1 (en) * 2016-05-31 2016-08-31 Ocinap S R L patch kit for the treatment of fungal nail infections
EP4129292A1 (en) 2021-08-04 2023-02-08 OnychoPharm GmbH Formulation for substituted 2-aminothiazoles in the treatment of fungal and fungal-bacterial infections of the nail
US11833134B1 (en) 2023-02-06 2023-12-05 King Faisal University Polymeric clotrimazole biofilm for the treatment of otomycosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180058A (en) * 1978-08-15 1979-12-25 Jacob Brem Method of treating pathological conditions of the nail
DE3520098A1 (en) * 1985-06-05 1986-12-11 Bayer Ag, 5090 Leverkusen FORMULAS CONTAINING AZOLE DERIVATIVES AND THEIR USE FOR ATRAUMATIC NAIL REMOVAL
ATE84208T1 (en) * 1985-11-04 1993-01-15 Owen Galderma Lab Inc FILM FORMING MEDICATION CARRIERS FOR ADMINISTRATION OF MEDICATIONS TO NAILS; METHOD OF USE.
DE3544983A1 (en) * 1985-12-19 1987-06-25 Hoechst Ag ANTIMYCOTIC EFFECTIVE NAIL POLISH
FR2613227B1 (en) * 1987-04-01 1990-12-28 Oreal PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE IN THE TREATMENT OF NAIL FUNGAL INFECTIONS
DE3720147A1 (en) * 1987-06-16 1988-12-29 Hoechst Ag ANTIMYCOTICALLY EFFECTIVE NAIL POLISH AND METHOD FOR THE PRODUCTION THEREOF
JPH0783286B2 (en) * 1988-09-16 1995-09-06 松下電器産業株式会社 AGC circuit
CA2008775C (en) * 1989-02-24 1998-12-22 Alberto Ferro Nail lacquer

Also Published As

Publication number Publication date
ATE150641T1 (en) 1997-04-15
JPH069342A (en) 1994-01-18
CA2093895C (en) 1997-04-15
EP0565072A1 (en) 1993-10-13
US5346692A (en) 1994-09-13
DE4212105A1 (en) 1993-10-14
EP0565072B1 (en) 1997-03-26
DE59305922D1 (en) 1997-04-30

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