CA2098302A1 - Medicaments - Google Patents

Medicaments

Info

Publication number
CA2098302A1
CA2098302A1 CA002098302A CA2098302A CA2098302A1 CA 2098302 A1 CA2098302 A1 CA 2098302A1 CA 002098302 A CA002098302 A CA 002098302A CA 2098302 A CA2098302 A CA 2098302A CA 2098302 A1 CA2098302 A1 CA 2098302A1
Authority
CA
Canada
Prior art keywords
medicaments
solvates
indole
dimethylamino
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002098302A
Other languages
French (fr)
Other versions
CA2098302C (en
Inventor
Joanne Craig
Derek L. Crookes
Stephen J. Skittrall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Joanne Craig
Derek L. Crookes
Stephen J. Skittrall
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joanne Craig, Derek L. Crookes, Stephen J. Skittrall, Glaxo Group Limited filed Critical Joanne Craig
Publication of CA2098302A1 publication Critical patent/CA2098302A1/en
Application granted granted Critical
Publication of CA2098302C publication Critical patent/CA2098302C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Abstract

3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide sulphate salt (2:1) and pharmaceutically accept-able solvates thereof are disclosed. The compound is of use in the preparation of pharmaceutical compositions, particularly for intranasal formulations, for use in the treatment of conditions associated with cephalic pain, in particular migraine.
CA002098302A 1990-12-12 1991-12-10 Medicaments Expired - Lifetime CA2098302C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments
GB9026998.6 1990-12-12
PCT/EP1991/002362 WO1992010477A1 (en) 1990-12-12 1991-12-10 Medicaments

Publications (2)

Publication Number Publication Date
CA2098302A1 true CA2098302A1 (en) 1992-06-13
CA2098302C CA2098302C (en) 2001-10-16

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002098302A Expired - Lifetime CA2098302C (en) 1990-12-12 1991-12-10 Medicaments

Country Status (36)

Country Link
US (2) US5554639A (en)
EP (1) EP0490689B1 (en)
JP (1) JP2994037B2 (en)
KR (1) KR100211479B1 (en)
CN (2) CN1030890C (en)
AP (1) AP230A (en)
AT (1) ATE119881T1 (en)
AU (1) AU650706B2 (en)
BE (1) BE1005085A3 (en)
CA (1) CA2098302C (en)
CH (1) CH684192A5 (en)
CY (1) CY2005A (en)
CZ (1) CZ281931B6 (en)
DE (1) DE69108200T2 (en)
DK (1) DK0490689T3 (en)
EG (1) EG20219A (en)
ES (1) ES2069836T3 (en)
FR (1) FR2670487B1 (en)
GB (2) GB9026998D0 (en)
GR (1) GR3015430T3 (en)
HK (1) HK82697A (en)
HU (1) HU211937A9 (en)
IE (1) IE62894B1 (en)
IL (1) IL100330A (en)
IS (1) IS1706B (en)
IT (1) IT1252868B (en)
MX (1) MX9102501A (en)
MY (1) MY109265A (en)
NL (1) NL9102071A (en)
NZ (1) NZ240942A (en)
PT (1) PT99757B (en)
RU (1) RU2108328C1 (en)
TW (2) TW205035B (en)
WO (1) WO1992010477A1 (en)
YU (1) YU48926B (en)
ZA (1) ZA919750B (en)

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UA27908C2 (en) * 1992-06-05 2000-10-16 Мерк Шарп Енд Дом Лімітед SULFATE SALT N, N-DIMETHYL-2- [5- (1,2,4-TRIAZOL-1YLMETHYL) -1H-INDOL-3-YL] ETHYLAMINE AND / OR SOLVATES, PHARMACEUTICAL AND METHOD OF TREATMENT
FR2749846B1 (en) * 1996-06-17 1998-09-11 Pf Medicament METHANESULFONATE SALT OF ARYLPIPERAZINE DERIVED FROM TRYPTAMINE AND ITS SOLVATES FOR PHARMACEUTICAL USE
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6106837A (en) * 1997-05-15 2000-08-22 Hirsch; Alan R. Method of treating headaches, and article of manufacture therefor
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
DE60228294D1 (en) * 2001-06-05 2008-09-25 Ronald Aung-Din Topische migränetherapie
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
SI1575566T1 (en) * 2002-12-26 2012-08-31 Pozen Inc Multilayer dosage forms containing naproxen and triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
EP1644004A4 (en) * 2003-06-20 2010-10-06 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
WO2005119607A2 (en) * 2004-06-03 2005-12-15 Tyfone, Inc. System and method for securing financial transactions
CA2569964A1 (en) * 2004-06-10 2005-12-29 Duramed Pharmaceuticals, Inc. Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US8283478B2 (en) 2005-05-20 2012-10-09 Janssen Pharmaceutica Nv Process for preparation of sulfamide derivatives
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
EA200870556A1 (en) 2006-05-19 2009-06-30 Янссен Фармацевтика Н.В. COMBINED THERAPY IN THE TREATMENT OF EPILEPSY AND RELATED DISORDERS
PL2124556T3 (en) 2006-10-09 2015-02-27 Charleston Laboratories Inc Pharmaceutical compositions
JP2010507585A (en) * 2006-10-19 2010-03-11 オースペックス・ファーマシューティカルズ・インコーポレイテッド Substituted indole
US20080275030A1 (en) 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
US8124126B2 (en) 2008-01-09 2012-02-28 Charleston Laboratories, Inc. Pharmaceutical compositions
US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
CN102046621B (en) 2008-05-27 2014-11-12 生物区科学管理控股有限公司 Antiviral salts
CA2765866C (en) * 2008-06-20 2016-06-21 Alphapharm Pty Ltd Single phase pharmaceutical composition of a 5-ht1 inhibitor and an nsaid
PE20110060A1 (en) 2008-06-23 2011-01-31 Janssen Pharmaceutica Nv CRYSTALLINE FORM OF (2S) - (-) - N- (6-CHLORO-2,3-DIHYDRO-BENZO [1,4] DIOXIN-2-ILMETHYL) -SULFAMIDE
JP2011526889A (en) * 2008-06-30 2011-10-20 アフギン ファーマ，エルエルシー Local nerve action therapy
US8815939B2 (en) 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
WO2011006012A1 (en) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Pharmaceutical compositions
KR101646079B1 (en) 2009-09-25 2016-08-12 닥터 레디스 레보러터리즈 리미티드 Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
AU2016226267A1 (en) 2015-03-02 2017-09-28 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
JP6897971B2 (en) 2015-05-15 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Methods and compositions for treating arthritis
JP2019507181A (en) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド Pharmaceutical composition
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US10723718B2 (en) 2017-11-07 2020-07-28 The Regents Of The University Of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
CN115335051A (en) * 2020-02-27 2022-11-11 拜尔哈文制药股份有限公司 Oral fast-dispersing dosage form of rimaidiazepam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
ITRM910922A1 (en) 1993-06-11
NZ240942A (en) 1994-03-25
AP9100339A0 (en) 1992-01-31
GB9026998D0 (en) 1991-01-30
GB2251614A (en) 1992-07-15
YU191491A (en) 1994-04-05
FR2670487A1 (en) 1992-06-19
IE62894B1 (en) 1995-03-08
CY2005A (en) 1997-12-05
HU211937A9 (en) 1996-01-29
RU2108328C1 (en) 1998-04-10
ES2069836T3 (en) 1995-05-16
CN1128259A (en) 1996-08-07
CH684192A5 (en) 1994-07-29
GB2251614B (en) 1994-12-14
HK82697A (en) 1997-06-27
BE1005085A3 (en) 1993-04-13
JP2994037B2 (en) 1999-12-27
JPH06503560A (en) 1994-04-21
WO1992010477A1 (en) 1992-06-25
PT99757B (en) 1999-05-31
IE914317A1 (en) 1992-06-17
CN1030890C (en) 1996-02-07
PT99757A (en) 1992-12-31
DE69108200D1 (en) 1995-04-20
IS3790A7 (en) 1992-06-13
IT1252868B (en) 1995-06-28
AP230A (en) 1993-01-27
YU48926B (en) 2002-12-10
CN1063099A (en) 1992-07-29
US5554639A (en) 1996-09-10
US5705520A (en) 1998-01-06
MY109265A (en) 1996-12-31
EP0490689A1 (en) 1992-06-17
ZA919750B (en) 1992-10-28
CN1050831C (en) 2000-03-29
CA2098302C (en) 2001-10-16
IL100330A (en) 1996-06-18
IL100330A0 (en) 1992-09-06
TW205035B (en) 1993-05-01
TW300886B (en) 1997-03-21
AU9072091A (en) 1992-07-08
KR100211479B1 (en) 1999-08-02
CZ114093A3 (en) 1994-02-16
GB9126297D0 (en) 1992-02-12
ATE119881T1 (en) 1995-04-15
EP0490689B1 (en) 1995-03-15
CZ281931B6 (en) 1997-04-16
MX9102501A (en) 1992-09-01
DE69108200T2 (en) 1995-07-20
EG20219A (en) 1997-11-30
IS1706B (en) 1998-12-10
NL9102071A (en) 1992-07-01
ITRM910922A0 (en) 1991-12-11
DK0490689T3 (en) 1995-05-22
FR2670487B1 (en) 1993-08-20
AU650706B2 (en) 1994-06-30
GR3015430T3 (en) 1995-06-30

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