CA2113587A1 - Vasoocculsion device containing radiopaque fibers - Google Patents

Vasoocculsion device containing radiopaque fibers

Info

Publication number
CA2113587A1
CA2113587A1 CA002113587A CA2113587A CA2113587A1 CA 2113587 A1 CA2113587 A1 CA 2113587A1 CA 002113587 A CA002113587 A CA 002113587A CA 2113587 A CA2113587 A CA 2113587A CA 2113587 A1 CA2113587 A1 CA 2113587A1
Authority
CA
Canada
Prior art keywords
fibers
braided
radiopaque
radiolucent
tubular member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002113587A
Other languages
French (fr)
Inventor
Erik T. Engelson
Gene Samson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Target Therapeutics Inc
Original Assignee
Erik T. Engelson
Gene Samson
Target Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erik T. Engelson, Gene Samson, Target Therapeutics, Inc. filed Critical Erik T. Engelson
Publication of CA2113587A1 publication Critical patent/CA2113587A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers

Abstract

ABSTRACT OF THE INVENTION

This invention is a vasoocclusive device. More particularly, it is a tubular vasoocclusion braid woven from at least radiopaque fibers. The braid may also be partially woven from radiolucent fibers. Optionally, the device may contain a fibrous center or wick in its interior. The device may be continuous or segmented and a fibrous covering or element may be attached.

Description

2113~87 , ;~ , ,~

. .
~ 5 VASOOCCLUSION DEVIC~ CONTAINING RADIOPAOU~ FIBERS
: 1 .
~ . .
Field of the I~ve~ion This invention is a vasoocclusive device. More particularly, it 18 a tubular vasoocclusion braid woven I from at least radiopaque fibers. The braid may also be partlally woven from radiolucent fibers. Optionally, the device may contain a flbrous center or wick in it i 15 interior. The device may be continuous or segmented and a fibrous covering or element may be attached.

Background of the Invention Vasoocclusion devices are surgical implements that are placed within the vascuIature of the human body, typically via a catheter, either to block the flow of blood through the vessel making-up that portion of the vasculature or to fonm a clot within an aneurysm stemming fron the vessel. one widely used vasoocclusive device is a helical wire coil having windings that are dimensioned to engage the walls of the vessels. Fibers may also be woven or laid crosswise through the windings to provide a sub~trate for clot formation and tissue growth within the chosen site. Coils having such a structure are readily commercially available.
U.S. Patent N`umber 4,994,069, to Richart et al., de w ribes a vasoocclusive coil which assume~ a ~i linear helical configuration when stretched, and a folded J, convoluted configuration ~hen relaxed. The coil is i 35 introduced into the human body in a stretched condition.

.~ .

2113a87 . .

When the coil reaches its intended site, the coil assumes its relaxed condition -- which is better suited to occlude the vessel -- and restricts blood flow beyond the space that it occupies.
U.S. Patent No. 5,226,gl1 to Chee et al.
teaches a helical vasoocclusion coil to which fibrous elements are attached in such a way that they will not be dislodged from the coil. The fibrous elements enhance the ability of the coil to fill space within the vasculature and to facilitate clot formation and tissue growth.
Care must be taken in creating combination fibroue vasoocclusive elements, i.e., those containing multiple cores and fibrous elements, since the fibrous elements may come off and migrate to vessels supplying blood to normal tissue. Fibrous elements, since they are not normally radiopaque, are difficult to find and to retrieve if separated from the metallic coil.
Nevertheless, it is desireable to increase the ratio of ---fibrou~ element to the metallic coil since the fibrous element increases the tendency of the coil assembly to --cause embolic and tissue growth. --The inventive vasoocclusive braid is desireable in that the ratio of fibrous material to metallic ---material is quite high, the fibrous material is held firmly in place due to the braided or woven configuration, and is easily placed within the body's vasculature.

Sun~K~c~ of the I~yen~Qa This inventlon is a vasoocclusive device comprising:
(a) a braided member which may be segmented, contlnuous, or segmented having a gap between the two end portion~, but ln each case having a first end and a 2113~7 ~ `

second end and woven at least from radiopaque fibers but optionally partially woven from radiolucent fibers; and optionally (b) at lea~t one fibrous woven element or 5 covering attached to the exterior of the braid, and -(c) a fibrous wick or center as the core of the braided member.

Brief De~c~ie~ion of the ~rawings Figure 1 is a ~chematic depiction of an overall system for introducing the inventive devices into the vessel of a human body.
Figures 2-5 are side views, partial cross-sectional side view~, or partial cutaway sideviews of a number of embadiments of the inventive vasoocclusive device.

Descri~tion o$ the Invention The vasoocclusive devices of this invention may be used in a manner similar to those described in U.S.
Pat. No. 4,994,069. Briefly, the inventive devices may be supplied in a pre-pac~aged form in a sterile cannula which is adapted to engage the prox;mAl end of a catheter. As is sho~n in Figure 1, once the catheter (100) is in place ~ithin a vessel (102) -- for instance, the distal end (104) of the catheter llOO) at an aneurysm ~106) -- the braid-containing cannula is placed into engagement with the proximal end of the catheter and the braide are transferred from the cannula lumen into the catheter lumen by exerting force on the proximal end of the coil. A flexible pu~her device ~10~) may be used to push the braid ~110) through the catheter ~100) to the deeired relea~e slte. The location o~ the braide ~110) may be observed due to the radiopaclty o~ the metallic etrands in the braid. Once at the eite, the braids are ., " ~
2~13~87 singly plunged from the catheter lumen into the ve~sel qite (106). ~ -Figure 2 depicts one embodiment of the va~oocclusive braid of the invention, generally ~hown as (120). The vasoocclusive device (120) has several component~: a first end (122), a ~econd end (124), and a braided or woven tubular fibrous element (126) extending from the first end (122) to a similar position on the second end (124). The tubular element (126) may be made up completely or partially of regular or randomly included radiopaque wlres (128) and optionally may be partially woven of, or cowoven with, radiolucent fibers or wires (130). The braided member may be woven using known weaving techniques and devices to form the tubular member (126) shown in this and the other figures.
Caps (122) and (124), variously in this configuration and in the others discussed herein, may be made of a radiopaque material such as platinum, tungsten, gold, silver, or alloys thereof, or other suitable generally radiopaque metals which are otherwise biologically inert. Radiopacity for the cap~ (122) and (124) is, of course, optional since the braid itself --contains radiopaque wires. The caps ~122) and (124) may be produced from a polymeric material or glue which seals the wires into the fibrous tubular element and keeps it from unraveling.
The diameter of the wire or fiber used in production of the braid will typically be in the range of 0.0005 and 0.005 lnches. The resulting woven braid diameter will normally be 0.008 to 0.018 inches.
Preferably, the braid diameter is 0.015 to 0.018 inches.
The wire may be a radlopaque material such as a metal or polymer, which polymer may be filled with a radiopaque material such a~ po~dered tantalum. Suitable metals and alloys include the platinum group metals especially 21135~7 platinum, rhodium, palladium, and tungsten, gold, silver, ~ tantalum, or alloys thereof. Preferred is a platinum-s tungsten alloy.
The wire may also be any of a variety of 5 stainless steels but may be made of other appropriate ~ materials including shape memory or highly elastic alloys i such as nickel-titanium alloys (48-58 atomic % nickel and 3 optionally containing modest amounts of iron); copper-zinc alloys (38.5-41.5 weight % zinc); copper-zinc alloys 10 containing 1-10 weight ~ of beryllium, silicon, tin, aluminum, or gallium; or nickel-aluminum alloys (36-38 atomic ~ aluminum). Particularly preferred are the alloy3 described in U.S. Pat Nos. 3,174,851, 3,351,463, and 3,753,700. Bspecially preferred is the Ti-Ni alloy 15 known as nitinol. Nitinol wire having the proper transition temperature allows the device to be introduced through the catheter in a linear fashion and upon raising the temperature of the vasoocclusive braid to body temperature, the wire in that braid assumes its pre-20 selected shape.
The radiolucent fibers may be made from biocompatible materials such as Dacron (polyester~, polyglycolic acid, polylactic acid, fluoropolymers (polytetrafluoroethylene), Nylon (polyamide), or silk.
25 The strands forming the braid should be reasonably heavy, e.g., having tensile strength of greater than about 0.15 pounds. Preferred materials are Dacron strands.
¦ The fibrous elements incorporated into the braid may be a bundle of individual fibers, e.g., between 30 5 and 100 flbers per fibrous bundle, preferably 20 to 30 fibers per bundle, or may be monofilaments.
The axial length of the braid will usually be in the range of 0.5 to 100 cm, more usually 2.5 to 40 cm.
Figure 3 shows another varlatlon of the inventive vasoocclusive device (140). In this variation, .. , ... ~

: , ,. . .~ . ~ . . .

2113587 ~

the tubular braid (142) contains a slightly higher incidence of radiopaque wires (12 a ) than the braid shown in Figure 2. This aspect is ~hown merely for the purpose of illustration. A3 noted above, the intent is to include at least radiopaque elements and optionally radiolucent elements which enhance the embolic features of the inventive braid. More importantly, Figure 3 shows the use of outlying fibers (144) which have been tied (or otherwise attached) to the tubular braid fibers. These fibers (144) are tied at various intervals to increase the propensity of the device to occlude blood. The outlying fibers (144) are typically Dacron but may be any of the natural and manmade fibers listed above.
Figure 4 shows another variation (150) of the inventive device in which tassels (152) are tied to the tubular braid to increase the breadth of the device and increase its overall clotting ability. These tassels are typically Dacron but, again, may be any of the fibrous materials described above. The tassels (152) may be short or long and may be singular or multiple depending upon the use intended.
Figure 5 shows a cutaway sideview of the invenSive device in which the braided tubular vasoocclusion device discussed above contains a core of radiolucent fibers. Although the fibers making up the braided tube may be radiolucent or radiopaque, the radiopaque fibers are preferred. The interior core of the braided tubular occlusion device (154) contains a bundle of radiolucent fibers (156) extending from one end of the braided tube to the other. The fiber bundle may be made up of fibers selected from those thermoplastics and natural materials noted above. The ends of the bundle may be ~ealed by heating those ends where the material~ 80 allow. The bundle may be pre-filled or infused with drugs ~ultable for later hastening of . , : : ,, ; . - . - .:

~, . . . .

coagulation after the device i8 introduced into the selected vascular site. The vasoocclusive device of IFigure 5 may also have outlying fibers attached to the !braided tubular element as has been discussed generally ! 5 above.
¦The braided ccclusion devices may be made in a variety of ways, as should be apparent from the ¦discussion above. The devices may be strung on a guidewire or other similar device for installation, ¦10 necessitating that the braided tubular device have open ends for pascage of the guidewires. The ends may be closed if 80 desired.
The ultimate shape of the device is a matter of choice. We contemplate that it may be straight, as introduced into the body lumen, or may be C~ shaped, circular, figure ~8~, random, or any other shape desirable to the physician user in view of the physical situation to be resolved.
Modifications of the above-described variations for carrying out the invention which are obvious to those of ordinary skill in the fields of medical device design generally, and vasoocclusion devices specifically, are intended to be within the scope of the following claims.

. . - .
~ , .
. ... ; :: -.. . . .

'

Claims (17)

1. A vasoocclusive device comprising a tubular member of braided fibers, at least a portion of said braided fibers being radiopaque, and having an interior cavity and a proximal and a distal end and which is of a size suitable for occluding a chosen site within the human vasculature.
2. The device of claim 1 where the tubular member braided fibers also comprise radiolucent fibers.
3. The device of claim 2 where the radiolucent fibers are selected from polyesters, polyglycolic acid, polylactic acid, fluoropolymers, polyamides, and silk.
4. The device of claim 3 where the radiolucent fibers comprise polyester.
5. The device of claim 1 where the radiopaque fibers comprise metals or polymers.
6. The device of claim 5 where the braided radiopaque fibers are selected from platinum, tungsten, gold, silver, tantalum, and alloys thereof, shape memory alloys, and stainless steels.
7. The device of claim 6 where the braided radiopaque fibers comprise a platinum-tungsten alloy.
8. The device of claim 6 where the braided radiopaque fibers comprise a shape memory alloy.
9. The device of claim 8 where at least a portion of the braided radiopaque fibers comprise nitinol.
10. The device of claim 1 additionally comprising braided fibers tied to the fibers in the braided tubular member.
11. The device of claim 10 where the fibers tied to the braided fibers are tied at multiple locations.
12. The device of claim 10 where the fibers tied to the braided fibers are tied so as to form tassels.
13. The device of claim 1 where the braided tubular member contains radiolucent fibers within the interior cavity.
14. The device of claim 13 where the radiolucent fibers in the interior cavity extend from the tubular member's distal end to the tubular member's proximal end.
15. The device of claim 13 where the radiolucent fibers in the interior cavity are selected from polyesters, polyglycolic acid, polylactic acid, fluoropolymers, polyamides, and silk.
16. The device of claim 15 where the radiolucent fibers in the interior cavity comprise polyester.
17. The device of claim 1 where the tubular member of braided fibers has a diameter of 0.015 to 0.018 inches.
CA002113587A 1993-01-15 1994-01-17 Vasoocculsion device containing radiopaque fibers Abandoned CA2113587A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US005,478 1993-01-15
US08/005,478 US5423849A (en) 1993-01-15 1993-01-15 Vasoocclusion device containing radiopaque fibers

Publications (1)

Publication Number Publication Date
CA2113587A1 true CA2113587A1 (en) 1994-07-16

Family

ID=21716084

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002113587A Abandoned CA2113587A1 (en) 1993-01-15 1994-01-17 Vasoocculsion device containing radiopaque fibers

Country Status (11)

Country Link
US (1) US5423849A (en)
EP (1) EP0679069B1 (en)
JP (1) JP2548514B2 (en)
AT (1) ATE224673T1 (en)
AU (1) AU669054B2 (en)
CA (1) CA2113587A1 (en)
DE (1) DE69332341T2 (en)
ES (1) ES2184757T3 (en)
IL (1) IL108182A0 (en)
TW (1) TW240165B (en)
WO (1) WO1994015534A1 (en)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003010A1 (en) * 1993-07-23 1995-02-02 Cook Incorporated A flexible stent having a pattern formed from a sheet of material
US6165210A (en) 1994-04-01 2000-12-26 Gore Enterprise Holdings, Inc. Self-expandable helical intravascular stent and stent-graft
US6001123A (en) 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
JP2825452B2 (en) * 1994-04-25 1998-11-18 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド Radiopak stent marker
JP4046760B2 (en) * 1994-05-19 2008-02-13 ボストン サイエンティフィック サイムド， インコーポレイテッド Improved tissue support device
US6331188B1 (en) 1994-08-31 2001-12-18 Gore Enterprise Holdings, Inc. Exterior supported self-expanding stent-graft
US6015429A (en) 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
EP0781114B1 (en) * 1994-09-16 2005-05-25 Ethicon Endo-Surgery, Inc. Devices for defining and marking tissue
NL9401533A (en) * 1994-09-21 1996-05-01 Cordis Europ MR-visible catheter with elements of paramagnetic material.
US5658264A (en) * 1994-11-10 1997-08-19 Target Therapeutics, Inc. High performance spiral-wound catheter
US5690671A (en) * 1994-12-13 1997-11-25 Micro Interventional Systems, Inc. Embolic elements and methods and apparatus for their delivery
US6638291B1 (en) 1995-04-20 2003-10-28 Micrus Corporation Three dimensional, low friction vasoocclusive coil, and method of manufacture
US5911731A (en) * 1995-04-20 1999-06-15 Target Therapeutics, Inc. Anatomically shaped vasoocclusive devices
US5645558A (en) * 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US8790363B2 (en) * 1995-04-20 2014-07-29 DePuy Synthes Products, LLC Three dimensional, low friction vasoocclusive coil, and method of manufacture
US6824553B1 (en) 1995-04-28 2004-11-30 Target Therapeutics, Inc. High performance braided catheter
US5891112A (en) * 1995-04-28 1999-04-06 Target Therapeutics, Inc. High performance superelastic alloy braid reinforced catheter
US6705323B1 (en) 1995-06-07 2004-03-16 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and methods
US6176240B1 (en) 1995-06-07 2001-01-23 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and their delivery
US6689162B1 (en) * 1995-10-11 2004-02-10 Boston Scientific Scimed, Inc. Braided composite prosthesis
US5658308A (en) * 1995-12-04 1997-08-19 Target Therapeutics, Inc. Bioactive occlusion coil
US6042605A (en) 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
DE69637245T2 (en) * 1995-12-14 2008-06-12 Gore Enterprise Holdings, Inc., Newark Crease resistant stent rail
JP2000503559A (en) 1995-12-14 2000-03-28 ゴア エンタープライズ ホールディングス，インコーポレイティド Apparatus and method for deploying a stent-graft
US5885258A (en) * 1996-02-23 1999-03-23 Memory Medical Systems, Inc. Medical instrument with slotted memory metal tube
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US5718159A (en) * 1996-04-30 1998-02-17 Schneider (Usa) Inc. Process for manufacturing three-dimensional braided covered stent
US6592617B2 (en) * 1996-04-30 2003-07-15 Boston Scientific Scimed, Inc. Three-dimensional braided covered stent
US6270477B1 (en) 1996-05-20 2001-08-07 Percusurge, Inc. Catheter for emboli containment
US6174329B1 (en) 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
US5964797A (en) * 1996-08-30 1999-10-12 Target Therapeutics, Inc. Electrolytically deployable braided vaso-occlusion device
US6096052A (en) * 1998-07-08 2000-08-01 Ovion, Inc. Occluding device and method of use
US20010041900A1 (en) * 1999-12-21 2001-11-15 Ovion, Inc. Occluding device and method of use
US7073504B2 (en) 1996-12-18 2006-07-11 Ams Research Corporation Contraceptive system and method of use
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US6551350B1 (en) 1996-12-23 2003-04-22 Gore Enterprise Holdings, Inc. Kink resistant bifurcated prosthesis
US5925061A (en) 1997-01-13 1999-07-20 Gore Enterprise Holdings, Inc. Low profile vascular stent
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
US5919224A (en) * 1997-02-12 1999-07-06 Schneider (Usa) Inc Medical device having a constricted region for occluding fluid flow in a body lumen
US20020133222A1 (en) * 1997-03-05 2002-09-19 Das Gladwin S. Expandable stent having a plurality of interconnected expansion modules
US6776792B1 (en) 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US5741327A (en) 1997-05-06 1998-04-21 Global Therapeutics, Inc. Surgical stent featuring radiopaque markers
US5746691A (en) 1997-06-06 1998-05-05 Global Therapeutics, Inc. Method for polishing surgical stents
US6174330B1 (en) 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US5980564A (en) * 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
US6340367B1 (en) 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6245103B1 (en) 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6156061A (en) * 1997-08-29 2000-12-05 Target Therapeutics, Inc. Fast-detaching electrically insulated implant
US6168570B1 (en) 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6626939B1 (en) * 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
US7070607B2 (en) 1998-01-27 2006-07-04 The Regents Of The University Of California Bioabsorbable polymeric implants and a method of using the same to create occlusions
US5935145A (en) * 1998-02-13 1999-08-10 Target Therapeutics, Inc. Vaso-occlusive device with attached polymeric materials
US5925060A (en) 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
DK0986334T3 (en) 1998-04-07 2005-01-24 Cook Inc Device for carocclusion with an asymmetric plurality of fibers
US6168615B1 (en) 1998-05-04 2001-01-02 Micrus Corporation Method and apparatus for occlusion and reinforcement of aneurysms
US7004962B2 (en) * 1998-07-27 2006-02-28 Schneider (Usa), Inc. Neuroaneurysm occlusion and delivery device and method of using same
US6187024B1 (en) 1998-11-10 2001-02-13 Target Therapeutics, Inc. Bioactive coating for vaso-occlusive devices
US8016852B2 (en) * 1998-11-10 2011-09-13 Stryker Corporation Bioactive components for incorporation with vaso-occlusive members
US6083259A (en) * 1998-11-16 2000-07-04 Frantzen; John J. Axially non-contracting flexible radially expandable stent
US6187034B1 (en) 1999-01-13 2001-02-13 John J. Frantzen Segmented stent for flexible stent delivery system
US6022359A (en) * 1999-01-13 2000-02-08 Frantzen; John J. Stent delivery system featuring a flexible balloon
US20020138094A1 (en) * 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
US6620192B1 (en) * 1999-03-16 2003-09-16 Advanced Cardiovascular Systems, Inc. Multilayer stent
US6464723B1 (en) 1999-04-22 2002-10-15 Advanced Cardiovascular Systems, Inc. Radiopaque stents
ATE377395T1 (en) * 1999-06-02 2007-11-15 Sethel Interventional Inc INTRACORPORAL CLOSURE DEVICE
US6280457B1 (en) * 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
US7229462B2 (en) * 1999-07-30 2007-06-12 Angioguard, Inc. Vascular filter system for carotid endarterectomy
US7229463B2 (en) * 1999-07-30 2007-06-12 Angioguard, Inc. Vascular filter system for cardiopulmonary bypass
US6709667B1 (en) 1999-08-23 2004-03-23 Conceptus, Inc. Deployment actuation system for intrafallopian contraception
US6585757B1 (en) 1999-09-15 2003-07-01 Advanced Cardiovascular Systems, Inc. Endovascular stent with radiopaque spine
DE19952505A1 (en) * 1999-10-29 2001-05-03 Gerd Hausdorf An expandable balloon for medical use comprises a thin-walled polymer shell coated with radio-opaque material in a pattern and is expandable on introduction of liquid and increasing pressure
US6602287B1 (en) 1999-12-08 2003-08-05 Advanced Cardiovascular Systems, Inc. Stent with anti-thrombogenic coating
WO2001066167A2 (en) * 2000-03-03 2001-09-13 Chuter Timothy A M Large vessel stents and occluders
US6656200B2 (en) 2000-04-07 2003-12-02 Collagen Matrix, Inc. Embolization device
US6652579B1 (en) 2000-06-22 2003-11-25 Advanced Cardiovascular Systems, Inc. Radiopaque stent
US6695833B1 (en) * 2000-09-27 2004-02-24 Nellix, Inc. Vascular stent-graft apparatus and forming method
US20030004533A1 (en) 2001-05-04 2003-01-02 Concentric Medical Bioactive polymer vaso-occlusive device
US7150737B2 (en) 2001-07-13 2006-12-19 Sci/Med Life Systems, Inc. Methods and apparatuses for navigating the subarachnoid space
US20030093105A1 (en) * 2001-07-13 2003-05-15 Scimed Life Systems, Inc. Guide catheter for introduction into the subarachnoid space and methods of use thereof
US7011647B2 (en) * 2001-07-13 2006-03-14 Scimed Life Systems, Inc. Introducer sheath
US7455666B2 (en) 2001-07-13 2008-11-25 Board Of Regents, The University Of Texas System Methods and apparatuses for navigating the subarachnoid space
JP2003048841A (en) * 2001-08-03 2003-02-21 Yasuhiko Tabata Composition for blocking blood vessel
FR2832307B1 (en) * 2001-11-19 2004-08-27 Sofradim Production DEVICE FOR OCCLUSIONING A BODILY CONDUIT, IN PARTICULAR A VARIOUS VEIN
EP1542616B1 (en) * 2002-09-20 2015-04-22 Endologix, Inc. Stent-graft with positioning anchor
WO2004058110A2 (en) * 2002-12-24 2004-07-15 Ovion, Inc. Contraceptive device and delivery system
CA2525792C (en) 2003-05-15 2015-10-13 Biomerix Corporation Reticulated elastomeric matrices, their manufacture and use in implantable devices
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
CA2484906C (en) * 2003-10-17 2012-12-04 Tyco Healthcare Group Lp Surgical access device and manufacture thereof
US7763077B2 (en) 2003-12-24 2010-07-27 Biomerix Corporation Repair of spinal annular defects and annulo-nucleoplasty regeneration
EP1711143B1 (en) * 2004-02-02 2013-04-10 Conceptus, Inc. Contraceptive with permeable and impermeable components
US20060009798A1 (en) * 2004-02-02 2006-01-12 Ams Research Corporation Methods and devices for occluding body lumens and/or enhancing tissue ingrowth
CA2779044C (en) * 2004-04-28 2014-12-16 Conceptus, Inc. Endoscopic delivery of medical devices
CA2567331C (en) * 2004-05-21 2012-08-14 Microtherapeutics, Inc. Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity
US8623067B2 (en) 2004-05-25 2014-01-07 Covidien Lp Methods and apparatus for luminal stenting
US8267985B2 (en) 2005-05-25 2012-09-18 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
EP2419048A4 (en) 2004-05-25 2014-04-09 Covidien Lp Vascular stenting for aneurysms
US20060206200A1 (en) 2004-05-25 2006-09-14 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
WO2005115118A2 (en) 2004-05-25 2005-12-08 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
US8617234B2 (en) 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
US7749242B2 (en) * 2004-06-21 2010-07-06 Boston Scientific Scimed, Inc. Expanding vaso-occlusive device
US8048145B2 (en) 2004-07-22 2011-11-01 Endologix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
EP1793744B1 (en) 2004-09-22 2008-12-17 Dendron GmbH Medical implant
ATE448737T1 (en) 2004-09-22 2009-12-15 Dendron Gmbh DEVICE FOR IMPLANTING MICROWL COILS
US20080140184A1 (en) * 2004-09-30 2008-06-12 Pellegrino-Gensey J Lee Scaffold device
US20060089672A1 (en) * 2004-10-25 2006-04-27 Jonathan Martinek Yarns containing filaments made from shape memory alloys
US7455688B2 (en) * 2004-11-12 2008-11-25 Con Interventional Systems, Inc. Ostial stent
WO2006055967A2 (en) * 2004-11-19 2006-05-26 Lumen Biomedical, Inc. Extendable device on an aspiration catheter
US8771294B2 (en) 2004-11-26 2014-07-08 Biomerix Corporation Aneurysm treatment devices and methods
DE102005007341B4 (en) * 2005-02-17 2007-10-11 Kasprzak, Piotr, Dr. Stent prosthesis for vascular surgery, especially in the area of the aortic arch
DE102005019782A1 (en) * 2005-04-28 2006-11-09 Dendron Gmbh Device for implantation of occlusion coils with internal securing means
CA2604081C (en) 2005-05-25 2013-11-26 Chestnut Medical Technologies, Inc. System and method for delivering and deploying a self-expanding device within a vessel
US8273101B2 (en) * 2005-05-25 2012-09-25 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
EP1903985A4 (en) 2005-07-07 2010-04-28 Nellix Inc Systems and methods for endovascular aneurysm treatment
US8052714B2 (en) * 2005-11-22 2011-11-08 Medtronic Vascular, Inc. Radiopaque fibers and filtration matrices
US7867547B2 (en) 2005-12-19 2011-01-11 Advanced Cardiovascular Systems, Inc. Selectively coating luminal surfaces of stents
US8152833B2 (en) 2006-02-22 2012-04-10 Tyco Healthcare Group Lp Embolic protection systems having radiopaque filter mesh
US20070219618A1 (en) * 2006-03-17 2007-09-20 Cully Edward H Endoprosthesis having multiple helically wound flexible framework elements
US8235047B2 (en) * 2006-03-30 2012-08-07 Conceptus, Inc. Methods and devices for deployment into a lumen
CN101448464B (en) 2006-04-17 2011-05-04 微治疗公司 System and method for mechanically positioning intravascular implants
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
US8069814B2 (en) 2006-05-04 2011-12-06 Advanced Cardiovascular Systems, Inc. Stent support devices
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
US8017237B2 (en) 2006-06-23 2011-09-13 Abbott Cardiovascular Systems, Inc. Nanoshells on polymers
CA2679112C (en) * 2007-03-05 2015-08-11 Boston Scientific Limited Deploying embolic coils
ES2437619T3 (en) 2007-03-13 2014-01-13 Covidien Lp An implant that includes a helical winding and a stretch resistant element
CA2680793C (en) 2007-03-13 2015-07-07 Microtherapeutics, Inc. An implant, a mandrel, and a method of forming an implant
US8048441B2 (en) 2007-06-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Nanobead releasing medical devices
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
EP2234562B1 (en) 2007-12-21 2019-02-27 MicroVention, Inc. A system and method of detecting implant detachment
EP2231030B1 (en) 2007-12-21 2019-02-27 MicroVention, Inc. System and method for locating detachment zone of a detachable implant
AU2009240419A1 (en) 2008-04-25 2009-10-29 Nellix, Inc. Stent graft delivery system
WO2009140437A1 (en) 2008-05-13 2009-11-19 Nfocus Neuromedical, Inc. Braid implant delivery systems
CA2726596A1 (en) 2008-06-04 2009-12-10 Nellix, Inc. Sealing apparatus and methods of use
FR2943905B1 (en) * 2009-04-06 2011-04-22 Braun Medical Sas EMBOLIZATION IMPLANT
US20110092955A1 (en) 2009-10-07 2011-04-21 Purdy Phillip D Pressure-Sensing Medical Devices, Systems and Methods, and Methods of Forming Medical Devices
US20110276078A1 (en) 2009-12-30 2011-11-10 Nellix, Inc. Filling structure for a graft system and methods of use
CA2795740C (en) 2010-04-14 2018-03-13 Microvention, Inc. Implant delivery device
US8801768B2 (en) 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
RU2599592C2 (en) 2011-02-04 2016-10-10 Концентрик Медикал, Инк. Device for embolic occlusion extraction
CN103648437B (en) 2011-04-06 2016-05-04 恩朵罗杰克斯国际控股有限公司 For the method and system of vascular aneurysms treatment
US9173736B2 (en) 2011-04-28 2015-11-03 Medtronic Vascular, Inc. Method of making an endoluminal vascular prosthesis
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9011480B2 (en) 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
WO2013119332A2 (en) 2012-02-09 2013-08-15 Stout Medical Group, L.P. Embolic device and methods of use
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9155647B2 (en) 2012-07-18 2015-10-13 Covidien Lp Methods and apparatus for luminal stenting
US9301831B2 (en) 2012-10-30 2016-04-05 Covidien Lp Methods for attaining a predetermined porosity of a vascular device
US9452070B2 (en) 2012-10-31 2016-09-27 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9943427B2 (en) 2012-11-06 2018-04-17 Covidien Lp Shaped occluding devices and methods of using the same
US9157174B2 (en) 2013-02-05 2015-10-13 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
US9119948B2 (en) 2013-02-20 2015-09-01 Covidien Lp Occlusive implants for hollow anatomical structures, delivery systems, and related methods
US10561509B2 (en) 2013-03-13 2020-02-18 DePuy Synthes Products, Inc. Braided stent with expansion ring and method of delivery
WO2014159093A1 (en) 2013-03-14 2014-10-02 Endologix, Inc. Method for forming materials in situ within a medical device
US8679150B1 (en) 2013-03-15 2014-03-25 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy methods
US8715314B1 (en) 2013-03-15 2014-05-06 Insera Therapeutics, Inc. Vascular treatment measurement methods
CN116172656A (en) 2013-03-15 2023-05-30 伊瑟拉医疗公司 Vascular treatment devices and methods
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
WO2017142874A2 (en) 2016-02-16 2017-08-24 Insera Therapeutics, Inc. Aspiration devices and anchored flow diverting devices
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9060777B1 (en) 2014-05-28 2015-06-23 Tw Medical Technologies, Llc Vaso-occlusive devices and methods of use
EP3148481A4 (en) 2014-05-28 2017-05-03 Stryker European Holdings I, LLC Vaso-occlusive devices and methods of use
AU2015292327A1 (en) 2014-07-25 2017-02-16 Incumedx, Inc. Covered embolic coils
US10206796B2 (en) 2014-08-27 2019-02-19 DePuy Synthes Products, Inc. Multi-strand implant with enhanced radiopacity
US10736730B2 (en) 2015-01-20 2020-08-11 Neurogami Medical, Inc. Vascular implant
US10925611B2 (en) 2015-01-20 2021-02-23 Neurogami Medical, Inc. Packaging for surgical implant
US11484319B2 (en) 2015-01-20 2022-11-01 Neurogami Medical, Inc. Delivery system for micrograft for treating intracranial aneurysms
EP3247285B1 (en) 2015-01-20 2021-08-11 Neurogami Medical, Inc. Micrograft for the treatment of intracranial aneurysms
US10857012B2 (en) 2015-01-20 2020-12-08 Neurogami Medical, Inc. Vascular implant
WO2016182949A1 (en) 2015-05-08 2016-11-17 Stryker European Holdings I, Llc Vaso-occlusive devices
CN108135686B (en) * 2015-09-10 2021-06-04 纳米纤维解决方案股份有限公司 Polymer electrospinning embolization devices and methods of use
EP3370788A4 (en) 2015-11-02 2019-07-31 Nanofiber Solutions, LLC Electrospun fibers having contrast agents and methods of making the same
CN105433991B (en) * 2015-12-28 2018-12-07 先健科技(深圳)有限公司 Plugging device
WO2017214431A2 (en) * 2016-06-10 2017-12-14 Stryker Corporation Braided medical devices
US10420563B2 (en) 2016-07-08 2019-09-24 Neurogami Medical, Inc. Delivery system insertable through body lumen
US10076428B2 (en) 2016-08-25 2018-09-18 DePuy Synthes Products, Inc. Expansion ring for a braided stent
US10292851B2 (en) 2016-09-30 2019-05-21 DePuy Synthes Products, Inc. Self-expanding device delivery apparatus with dual function bump
WO2018217653A1 (en) 2017-05-22 2018-11-29 Boston Scientific Scimed, Inc. Devices and methods of use with devices having a radiopaque filament
AU2019204522A1 (en) 2018-07-30 2020-02-13 DePuy Synthes Products, Inc. Systems and methods of manufacturing and using an expansion ring
US10456280B1 (en) 2018-08-06 2019-10-29 DePuy Synthes Products, Inc. Systems and methods of using a braided implant
US10278848B1 (en) 2018-08-06 2019-05-07 DePuy Synthes Products, Inc. Stent delivery with expansion assisting delivery wire
US11039944B2 (en) 2018-12-27 2021-06-22 DePuy Synthes Products, Inc. Braided stent system with one or more expansion rings
US20210267644A1 (en) * 2020-03-02 2021-09-02 Cleveland State University Metal plate with one-way shape memory effect

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105492A (en) * 1958-10-01 1963-10-01 Us Catheter & Instr Corp Synthetic blood vessel grafts
US3272204A (en) * 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands
US3826171A (en) * 1970-04-20 1974-07-30 J Kaar Guitar string
JPS6028434Y2 (en) * 1980-06-16 1985-08-28 建部 容保 Artificial blood vessel
US4364392A (en) * 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
US4512338A (en) * 1983-01-25 1985-04-23 Balko Alexander B Process for restoring patency to body vessels
US5190546A (en) * 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US4798606A (en) * 1985-02-26 1989-01-17 Corvita Corporation Reinforcing structure for cardiovascular graft
US4629458A (en) * 1985-02-26 1986-12-16 Cordis Corporation Reinforcing structure for cardiovascular graft
US4708718A (en) * 1985-07-02 1987-11-24 Target Therapeutics Hyperthermic treatment of tumors
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4762922A (en) * 1987-07-01 1988-08-09 Squibb Corporation 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
US4820298A (en) * 1987-11-20 1989-04-11 Leveen Eric G Internal vascular prosthesis
US4877030A (en) * 1988-02-02 1989-10-31 Andreas Beck Device for the widening of blood vessels
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5071407A (en) * 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5167624A (en) * 1990-11-09 1992-12-01 Catheter Research, Inc. Embolus delivery system and method
US5217484A (en) * 1991-06-07 1993-06-08 Marks Michael P Retractable-wire catheter device and method
US5226911A (en) * 1991-10-02 1993-07-13 Target Therapeutics Vasoocclusion coil with attached fibrous element(s)
US5256146A (en) * 1991-10-11 1993-10-26 W. D. Ensminger Vascular catheterization system with catheter anchoring feature
US5261916A (en) * 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5250071A (en) * 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use

Also Published As

Publication number Publication date
IL108182A0 (en) 1994-04-12
JP2548514B2 (en) 1996-10-30
EP0679069A4 (en) 1996-07-24
TW240165B (en) 1995-02-11
DE69332341T2 (en) 2003-01-23
WO1994015534A1 (en) 1994-07-21
AU669054B2 (en) 1996-05-23
JPH0759787A (en) 1995-03-07
EP0679069B1 (en) 2002-09-25
ES2184757T3 (en) 2003-04-16
AU5985894A (en) 1994-08-15
ATE224673T1 (en) 2002-10-15
US5423849A (en) 1995-06-13
EP0679069A1 (en) 1995-11-02
DE69332341D1 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
US5423849A (en) Vasoocclusion device containing radiopaque fibers
JP2553309B2 (en) Vascular occlusion device with tubular cover of woven or knitted fibers
AU656283B2 (en) Vasoocclusion coil with attached fibrous element(s)
EP0964648B1 (en) Vaso-occlusive coil with conical ends
JP2908363B2 (en) Bioactive occlusion coil
US5582619A (en) Stretch resistant vaso-occlusive coils
CA2084749C (en) Vasoocclusion coil with attached fibrous element(s)
EP0754435A1 (en) Stretch-resistant vaso-occlusive coils
JP2002507902A (en) Stretch-resistant vasoocclusive coil (II)
EP0715503A1 (en) Vasoocclusive coils with thrombogenic enhancing fibers

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued