CA2123133A1 - Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system - Google Patents

Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system

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Publication number
CA2123133A1
CA2123133A1 CA002123133A CA2123133A CA2123133A1 CA 2123133 A1 CA2123133 A1 CA 2123133A1 CA 002123133 A CA002123133 A CA 002123133A CA 2123133 A CA2123133 A CA 2123133A CA 2123133 A1 CA2123133 A1 CA 2123133A1
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Prior art keywords
donor
chromophores
fluorophores
hybridization
energy transfer
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CA002123133A
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French (fr)
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CA2123133C (en
Inventor
Michael J. Heller
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Nanogen Inc
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Individual
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    • Y10T436/13—Tracers or tags

Abstract

The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one, fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore, and methods using the photonic structures.
CA002123133A 1991-11-07 1992-11-06 Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system Expired - Fee Related CA2123133C (en)

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US79026291A 1991-11-07 1991-11-07
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PCT/US1992/009827 WO1993009128A1 (en) 1991-11-07 1992-11-06 Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system

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EP1067134A2 (en) 2001-01-10
ATE201692T1 (en) 2001-06-15
JP3509859B2 (en) 2004-03-22
JPH07502992A (en) 1995-03-30
US6416953B1 (en) 2002-07-09
AU667497B2 (en) 1996-03-28
DE69231853D1 (en) 2001-07-05
WO1993009128A1 (en) 1993-05-13
CA2123133C (en) 2005-01-04
US6911310B2 (en) 2005-06-28
EP0620822A1 (en) 1994-10-26
EP1067134A3 (en) 2001-05-02
US6162603A (en) 2000-12-19
EP1067134B1 (en) 2004-07-28
US5565322A (en) 1996-10-15
DE69231853T2 (en) 2001-09-13
EP0620822B1 (en) 2001-05-30
DK0620822T3 (en) 2001-08-27
DE69233391D1 (en) 2004-09-02
GR3036456T3 (en) 2001-11-30
US5532129A (en) 1996-07-02
US5849489A (en) 1998-12-15
AU3136493A (en) 1993-06-07
US20030054361A1 (en) 2003-03-20
ATE272068T1 (en) 2004-08-15
US20070042386A1 (en) 2007-02-22
EP0620822A4 (en) 1996-01-10
ES2159282T3 (en) 2001-10-01

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