CA2138647A1 - Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses - Google Patents

Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses

Info

Publication number
CA2138647A1
CA2138647A1 CA002138647A CA2138647A CA2138647A1 CA 2138647 A1 CA2138647 A1 CA 2138647A1 CA 002138647 A CA002138647 A CA 002138647A CA 2138647 A CA2138647 A CA 2138647A CA 2138647 A1 CA2138647 A1 CA 2138647A1
Authority
CA
Canada
Prior art keywords
peptides
labeled
radioactively
imaging
therapeutic uses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002138647A
Other languages
French (fr)
Other versions
CA2138647C (en
Inventor
Richard T. Dean
John Lister-James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diatide Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2138647A1 publication Critical patent/CA2138647A1/en
Application granted granted Critical
Publication of CA2138647C publication Critical patent/CA2138647C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Abstract

This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for produ-cing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and em-bodiments of such peptides labeled with technetium-99m (Tc-99m), as well as methods and kits for making, radiolabeling and us-ing such peptides to image sites in a mammalian body. The invention also relates to peptide derivatives and analogues of somatostantin labeled with rhenium-186(186Re) and rhenium-188(188Re), and methods and kits for making, radiolabeling and using such peptides therapeutically in a mammalian body.
CA002138647A 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses Expired - Fee Related CA2138647C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/902,935 US5716596A (en) 1992-06-23 1992-06-23 Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US902,935 1992-06-23
PCT/US1993/006029 WO1994000489A2 (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostantin-derived peptides for imaging and therapeutic uses

Publications (2)

Publication Number Publication Date
CA2138647A1 true CA2138647A1 (en) 1994-01-06
CA2138647C CA2138647C (en) 2002-11-12

Family

ID=25416650

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002138647A Expired - Fee Related CA2138647C (en) 1992-06-23 1993-06-23 Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses

Country Status (10)

Country Link
US (5) US5716596A (en)
EP (2) EP1094074A3 (en)
JP (1) JPH08503924A (en)
AT (1) ATE203754T1 (en)
AU (1) AU690071B2 (en)
CA (1) CA2138647C (en)
DE (1) DE69330521T2 (en)
DK (1) DK0649434T3 (en)
ES (1) ES2164667T3 (en)
WO (1) WO1994000489A2 (en)

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Also Published As

Publication number Publication date
US5833942A (en) 1998-11-10
WO1994000489A3 (en) 1994-03-31
EP1094074A3 (en) 2002-01-09
WO1994000489A2 (en) 1994-01-06
US5843401A (en) 1998-12-01
EP0649434A1 (en) 1995-04-26
ES2164667T3 (en) 2002-03-01
US5820845A (en) 1998-10-13
ATE203754T1 (en) 2001-08-15
US5814298A (en) 1998-09-29
CA2138647C (en) 2002-11-12
EP1094074A2 (en) 2001-04-25
JPH08503924A (en) 1996-04-30
DE69330521D1 (en) 2001-09-06
AU690071B2 (en) 1998-04-23
DE69330521T2 (en) 2002-05-16
AU4768893A (en) 1994-01-24
EP0649434B1 (en) 2001-08-01
US5716596A (en) 1998-02-10
DK0649434T3 (en) 2001-11-12

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