CA2141691A1 - Solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof - Google Patents

Solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof

Info

Publication number
CA2141691A1
CA2141691A1 CA002141691A CA2141691A CA2141691A1 CA 2141691 A1 CA2141691 A1 CA 2141691A1 CA 002141691 A CA002141691 A CA 002141691A CA 2141691 A CA2141691 A CA 2141691A CA 2141691 A1 CA2141691 A1 CA 2141691A1
Authority
CA
Canada
Prior art keywords
extended
production
release profile
solid pharmaceutical
dosage forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002141691A
Other languages
French (fr)
Other versions
CA2141691C (en
Inventor
Eberhard Nurnberg
Stefan Ritsert
Erhard Seiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Eberhard Nurnberg
Stefan Ritsert
Erhard Seiller
Merz + Co. Gmbh & Co.
Merz Pharma Gmbh & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eberhard Nurnberg, Stefan Ritsert, Erhard Seiller, Merz + Co. Gmbh & Co., Merz Pharma Gmbh & Co. Kgaa filed Critical Eberhard Nurnberg
Publication of CA2141691A1 publication Critical patent/CA2141691A1/en
Application granted granted Critical
Publication of CA2141691C publication Critical patent/CA2141691C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention provides solid pharmaceutical compositions in dosage form containing an active ingredient ar princ-iple, preferably memantine, which exhibit an extended two-phase release profile and which are characterized by the presence of both a water-soluble and a water-insoluble salt of casein, preferably sodium and calcium caseinate, in the matrix thereof, in broad proportions and in a total amount between 5 and 98% by weight of the composition, and with a process for the production there-of.
CA002141691A 1992-08-04 1993-08-04 Solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof Expired - Lifetime CA2141691C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4225730A DE4225730C2 (en) 1992-08-04 1992-08-04 Process for the preparation of solid dosage forms with protracted 2-stage release
DEP4225730.1 1992-08-04
PCT/EP1993/002074 WO1994003158A1 (en) 1992-08-04 1993-08-04 Solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof

Publications (2)

Publication Number Publication Date
CA2141691A1 true CA2141691A1 (en) 1994-02-17
CA2141691C CA2141691C (en) 2002-04-09

Family

ID=6464804

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002141691A Expired - Lifetime CA2141691C (en) 1992-08-04 1993-08-04 Solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof

Country Status (17)

Country Link
US (1) US5382601A (en)
EP (1) EP0582186B1 (en)
JP (1) JP3560244B2 (en)
CN (1) CN1086708A (en)
AT (1) ATE176866T1 (en)
AU (1) AU669731B2 (en)
CA (1) CA2141691C (en)
DE (2) DE4225730C2 (en)
DK (1) DK0582186T3 (en)
ES (1) ES2128369T3 (en)
GR (1) GR3030227T3 (en)
IL (1) IL106580A (en)
LT (1) LT3201B (en)
LV (1) LV10182B (en)
MX (1) MX9304675A (en)
WO (1) WO1994003158A1 (en)
ZA (1) ZA935614B (en)

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US5952389A (en) * 1998-01-13 1999-09-14 Synchroneuron Methods of treating tardive dyskinesia and other movement disorders
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US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
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AU2005215775B2 (en) * 2004-02-13 2011-02-03 Neuromolecular, Inc. Combination of a NMDA receptor antagonist and an anti-depressive drug MAO-inhibitor or a GADPH-inhibitor for the treatment of psychiatric conditions
US20050245460A1 (en) * 2004-02-13 2005-11-03 Meyerson Laurence R Methods and compositions for the treatment of epilepsy, seizure disorders, and other CNS disorders
KR100901927B1 (en) * 2004-06-17 2009-06-10 메르츠 파마 게엠베하 운트 코. 카가아 Drinkable immediate release tablet made with direct compression of memantine or neramexane
AU2005328701B2 (en) 2004-06-17 2009-08-13 Merz Pharma Gmbh & Co. Kgaa Drinkable immediate release tablet made with direct compression of memantine or neramexane
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US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
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US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
EP1830886B1 (en) * 2004-12-27 2016-04-13 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
WO2006121560A2 (en) 2005-04-06 2006-11-16 Adamas Pharmaceuticals, Inc. Methods and compositions for treatment of cns disorders
US20090023778A1 (en) * 2005-04-28 2009-01-22 Eisai R&D Management Co., Ltd. Composition Containing Anti-Dementia Drug
US20060270742A1 (en) * 2005-05-02 2006-11-30 Jane Staunton Compositions and methods for the treatment of neurodegenerative diseases
WO2006138227A1 (en) * 2005-06-16 2006-12-28 Forest Laboratories, Inc. Modified and immediate release memantine bead formulation
CA2634507A1 (en) * 2005-12-23 2007-06-28 Alk-Abello A/S Method for dissolution testing of pharmaceutical products
EP2040676A2 (en) * 2006-07-06 2009-04-01 Forest Laboratories, Inc. Orally dissolving formulations of memantine
US7624743B2 (en) * 2006-09-14 2009-12-01 Halliburton Energy Services, Inc. Methods and compositions for thermally treating a conduit used for hydrocarbon production or transmission to help remove paraffin wax buildup
GB0623897D0 (en) * 2006-11-30 2007-01-10 Pliva Istrazivanje I Razvoj D Pharmaceutical composition of memantine
US20080182908A1 (en) * 2007-01-25 2008-07-31 Vinita Umashankar Vyas Pharmaceutical compositions comprising memantine
US20100215740A1 (en) 2007-10-10 2010-08-26 Rubicon Research Private Limited Taste-masked orally disintegrating tablets of memantine hydrochloride
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
EP2506709B2 (en) 2009-12-02 2019-10-09 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
EP2363119A1 (en) * 2010-03-05 2011-09-07 Centre Hospitalier Universitaire d'Angers New pharmaceutical composition suitable for treating persons affected by neurodegenerative or neurovascular diseases
WO2012101653A2 (en) 2011-01-25 2012-08-02 Cadila Healthcare Limited Modified release pharmaceutical compositions memantine
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FR2980973B1 (en) * 2011-10-11 2013-11-15 Univ Clermont Auvergne COMPOSITION FOR THE PROPHYLACTIC TREATMENT OF NEUROPATHIC PAIN.
US20130274342A1 (en) * 2012-04-12 2013-10-17 Cerecor, Inc. Compositions and methods for treating cough
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US10213394B1 (en) 2018-02-15 2019-02-26 Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság Composition and method for treating neurological disease
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Also Published As

Publication number Publication date
ATE176866T1 (en) 1999-03-15
LTIP839A (en) 1994-08-25
CA2141691C (en) 2002-04-09
JPH07509479A (en) 1995-10-19
WO1994003158A1 (en) 1994-02-17
DE4225730C2 (en) 2003-04-30
DE59309388D1 (en) 1999-04-01
ES2128369T3 (en) 1999-05-16
US5382601A (en) 1995-01-17
EP0582186B1 (en) 1999-02-24
JP3560244B2 (en) 2004-09-02
LV10182A (en) 1994-10-20
IL106580A0 (en) 1993-12-08
AU4706993A (en) 1994-03-03
GR3030227T3 (en) 1999-08-31
MX9304675A (en) 1994-03-31
LV10182B (en) 1995-04-20
AU669731B2 (en) 1996-06-20
LT3201B (en) 1995-03-27
IL106580A (en) 1998-02-08
ZA935614B (en) 1995-02-03
DE4225730A1 (en) 1994-02-10
CN1086708A (en) 1994-05-18
DK0582186T3 (en) 1999-09-27
EP0582186A1 (en) 1994-02-09

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Legal Events

Date Code Title Description
EEER Examination request