CA2151801A1 - 3'-modified oligonucleotide derivatives - Google Patents
3'-modified oligonucleotide derivativesInfo
- Publication number
- CA2151801A1 CA2151801A1 CA002151801A CA2151801A CA2151801A1 CA 2151801 A1 CA2151801 A1 CA 2151801A1 CA 002151801 A CA002151801 A CA 002151801A CA 2151801 A CA2151801 A CA 2151801A CA 2151801 A1 CA2151801 A1 CA 2151801A1
- Authority
- CA
- Canada
- Prior art keywords
- modified oligonucleotide
- oligonucleotides
- see formula
- oligonucleotide derivatives
- ribozymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/40—Succinic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Novel oligonucleotide analogs of the formulae I and II (see Formula I) (see Formula II) in which A, B, D, R1, R2, T, U, V, W, X, Y, Z, a, b, m, m', n and n' have the meanings stated in the description, with valuable physical, biological and pharmacological properties, and a process for the preparation thereof are described. Application thereof relates to the use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex forming oligonucleotides), as probes for detecting nucleic acids and as aids in molecular biology.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2628883 CA2628883C (en) | 1994-06-15 | 1995-06-14 | Novel 3'-modified oligonucleotide derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4420737.9 | 1994-06-15 | ||
DE4420737A DE4420737A1 (en) | 1994-06-15 | 1994-06-15 | New 3'-derivatised oligo:nucleotide analogues |
DE4424263A DE4424263A1 (en) | 1994-07-09 | 1994-07-09 | New 3'-derivatised oligo:nucleotide analogues |
DEP4424263.8 | 1994-07-09 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2628883 Division CA2628883C (en) | 1994-06-15 | 1995-06-14 | Novel 3'-modified oligonucleotide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2151801A1 true CA2151801A1 (en) | 1995-12-16 |
CA2151801C CA2151801C (en) | 2008-08-19 |
Family
ID=25937419
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2151801 Expired - Fee Related CA2151801C (en) | 1994-06-15 | 1995-06-14 | 3'-modified oligonucleotide derivatives |
CA 2628883 Expired - Fee Related CA2628883C (en) | 1994-06-15 | 1995-06-14 | Novel 3'-modified oligonucleotide derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2628883 Expired - Fee Related CA2628883C (en) | 1994-06-15 | 1995-06-14 | Novel 3'-modified oligonucleotide derivatives |
Country Status (9)
Country | Link |
---|---|
US (1) | US5696248A (en) |
EP (1) | EP0688784B1 (en) |
JP (1) | JP4398517B2 (en) |
AT (1) | ATE312840T1 (en) |
AU (1) | AU701333B2 (en) |
CA (2) | CA2151801C (en) |
DE (1) | DE59511027D1 (en) |
DK (1) | DK0688784T3 (en) |
ES (1) | ES2253740T3 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
US7309692B1 (en) | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
US6977244B2 (en) * | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
JP2002501505A (en) * | 1997-05-05 | 2002-01-15 | アベンティス、ファルマ、ドイチュラント、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | Modified antisense nucleotide complementary to human Ha-ras gene fragment |
US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US20040186071A1 (en) | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
US5968826A (en) * | 1998-10-05 | 1999-10-19 | Isis Pharmaceuticals Inc. | Antisense inhibition of integrin α4 expression |
CA2357986C (en) * | 1998-12-30 | 2014-02-11 | Oligos Etc. Inc. | Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof |
DE10019252A1 (en) * | 2000-04-18 | 2001-10-31 | Klaus Karl Degitz | Polydeoxyribonucleotides to inhibit ICAM-1 gene expression |
US20040043950A1 (en) * | 2002-01-03 | 2004-03-04 | Board Of Regents, The University Of Texas System | WT1 antisense oligos for the inhibition of breast cancer |
GB0209539D0 (en) * | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
AR040996A1 (en) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | IMMUNE STIMULATING NUCLEIC ACIDS |
WO2004053104A2 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5’ cpg nucleic acids and methods of use |
JP4782668B2 (en) | 2003-03-31 | 2011-09-28 | エフ.ホフマン−ラ ロシュ アーゲー | Compositions and methods for detecting certain flaviviruses, including members of the Japanese encephalitis virus serogroup |
SG122973A1 (en) | 2003-10-30 | 2006-06-29 | Coley Pharm Gmbh | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
CA2584614A1 (en) | 2004-10-20 | 2006-08-24 | Antisense Therapeutics Ltd | Antisense modulation of integrin .alpha.4 expression |
PT2078080E (en) | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
EP2222851B1 (en) | 2007-11-20 | 2017-06-28 | Ionis Pharmaceuticals, Inc. | Modulation of cd40 expression |
WO2011032095A1 (en) * | 2009-09-11 | 2011-03-17 | Segetis, Inc. | Ketal esters of oxocarboxylic acids and process of making |
EP3330278A1 (en) | 2012-02-08 | 2018-06-06 | Ionis Pharmaceuticals, Inc. | Modulation of rna by repeat targeting |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646261A (en) * | 1992-01-22 | 1997-07-08 | Hoechst Aktiengesellschaft | 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use |
IL104461A (en) * | 1992-01-22 | 2001-05-20 | Hoechst Ag | Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them |
-
1995
- 1995-06-05 US US08/462,305 patent/US5696248A/en not_active Expired - Lifetime
- 1995-06-09 DE DE59511027T patent/DE59511027D1/en not_active Expired - Lifetime
- 1995-06-09 EP EP19950108896 patent/EP0688784B1/en not_active Expired - Lifetime
- 1995-06-09 DK DK95108896T patent/DK0688784T3/en active
- 1995-06-09 AT AT95108896T patent/ATE312840T1/en active
- 1995-06-09 ES ES95108896T patent/ES2253740T3/en not_active Expired - Lifetime
- 1995-06-13 AU AU21659/95A patent/AU701333B2/en not_active Ceased
- 1995-06-14 JP JP17043695A patent/JP4398517B2/en not_active Expired - Fee Related
- 1995-06-14 CA CA 2151801 patent/CA2151801C/en not_active Expired - Fee Related
- 1995-06-14 CA CA 2628883 patent/CA2628883C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0688784B1 (en) | 2005-12-14 |
ATE312840T1 (en) | 2005-12-15 |
JPH0827178A (en) | 1996-01-30 |
ES2253740T3 (en) | 2006-06-01 |
DE59511027D1 (en) | 2006-01-19 |
EP0688784A2 (en) | 1995-12-27 |
JP4398517B2 (en) | 2010-01-13 |
US5696248A (en) | 1997-12-09 |
AU701333B2 (en) | 1999-01-28 |
AU2165995A (en) | 1995-12-21 |
CA2151801C (en) | 2008-08-19 |
CA2628883A1 (en) | 1995-12-16 |
EP0688784A3 (en) | 1997-01-22 |
CA2628883C (en) | 2011-02-15 |
DK0688784T3 (en) | 2006-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150615 |