CA2151801A1 - 3'-modified oligonucleotide derivatives - Google Patents

3'-modified oligonucleotide derivatives

Info

Publication number
CA2151801A1
CA2151801A1 CA002151801A CA2151801A CA2151801A1 CA 2151801 A1 CA2151801 A1 CA 2151801A1 CA 002151801 A CA002151801 A CA 002151801A CA 2151801 A CA2151801 A CA 2151801A CA 2151801 A1 CA2151801 A1 CA 2151801A1
Authority
CA
Canada
Prior art keywords
modified oligonucleotide
oligonucleotides
see formula
oligonucleotide derivatives
ribozymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002151801A
Other languages
French (fr)
Other versions
CA2151801C (en
Inventor
Anuschirwan Peyman
Eugen Uhlmann
Carolin Carolus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Anuschirwan Peyman
Eugen Uhlmann
Carolin Carolus
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4420737A external-priority patent/DE4420737A1/en
Priority claimed from DE4424263A external-priority patent/DE4424263A1/en
Application filed by Anuschirwan Peyman, Eugen Uhlmann, Carolin Carolus, Hoechst Aktiengesellschaft filed Critical Anuschirwan Peyman
Priority to CA 2628883 priority Critical patent/CA2628883C/en
Publication of CA2151801A1 publication Critical patent/CA2151801A1/en
Application granted granted Critical
Publication of CA2151801C publication Critical patent/CA2151801C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

Novel oligonucleotide analogs of the formulae I and II (see Formula I) (see Formula II) in which A, B, D, R1, R2, T, U, V, W, X, Y, Z, a, b, m, m', n and n' have the meanings stated in the description, with valuable physical, biological and pharmacological properties, and a process for the preparation thereof are described. Application thereof relates to the use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex forming oligonucleotides), as probes for detecting nucleic acids and as aids in molecular biology.
CA 2151801 1994-06-15 1995-06-14 3'-modified oligonucleotide derivatives Expired - Fee Related CA2151801C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2628883 CA2628883C (en) 1994-06-15 1995-06-14 Novel 3'-modified oligonucleotide derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4420737A DE4420737A1 (en) 1994-06-15 1994-06-15 New 3'-derivatised oligo:nucleotide analogues
DEP4420737.9 1994-06-15
DEP4424263.8 1994-07-09
DE4424263A DE4424263A1 (en) 1994-07-09 1994-07-09 New 3'-derivatised oligo:nucleotide analogues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA 2628883 Division CA2628883C (en) 1994-06-15 1995-06-14 Novel 3'-modified oligonucleotide derivatives

Publications (2)

Publication Number Publication Date
CA2151801A1 true CA2151801A1 (en) 1995-12-16
CA2151801C CA2151801C (en) 2008-08-19

Family

ID=25937419

Family Applications (2)

Application Number Title Priority Date Filing Date
CA 2151801 Expired - Fee Related CA2151801C (en) 1994-06-15 1995-06-14 3'-modified oligonucleotide derivatives
CA 2628883 Expired - Fee Related CA2628883C (en) 1994-06-15 1995-06-14 Novel 3'-modified oligonucleotide derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA 2628883 Expired - Fee Related CA2628883C (en) 1994-06-15 1995-06-14 Novel 3'-modified oligonucleotide derivatives

Country Status (9)

Country Link
US (1) US5696248A (en)
EP (1) EP0688784B1 (en)
JP (1) JP4398517B2 (en)
AT (1) ATE312840T1 (en)
AU (1) AU701333B2 (en)
CA (2) CA2151801C (en)
DE (1) DE59511027D1 (en)
DK (1) DK0688784T3 (en)
ES (1) ES2253740T3 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US7309692B1 (en) * 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
CA2288946A1 (en) * 1997-05-05 1998-11-12 Hoechst Marion Roussel Deutschland Gmbh Modified antisense nucleotides complementary to a section of the human ha-ras gene
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
CA2357986C (en) * 1998-12-30 2014-02-11 Oligos Etc. Inc. Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof
DE10019252A1 (en) * 2000-04-18 2001-10-31 Klaus Karl Degitz Polydeoxyribonucleotides to inhibit ICAM-1 gene expression
WO2003061386A1 (en) * 2002-01-03 2003-07-31 Board Of Regents, The University Of Texas System Wt1 antisense oligos for the inhibition of breast cancer
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
AR040996A1 (en) 2002-08-19 2005-04-27 Coley Pharm Group Inc IMMUNE STIMULATING NUCLEIC ACIDS
CA2502015A1 (en) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5' cpg nucleic acids and methods of use
CA2520538C (en) 2003-03-31 2014-04-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
UA88457C2 (en) 2003-10-30 2009-10-26 Коли Фармасьютикал Гмбх Immunostimulatory nucleic acid with enhanced immunostimulatory potency
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
NZ554277A (en) 2004-10-20 2010-09-30 Antisense Therapeutics Ltd Antisense modulation of integrin alpha 4 expression
KR101251707B1 (en) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 CpG oligonucleotide analogs containing hydrophobic T analogs with enhanced immunostimulatory activity
USRE47320E1 (en) 2007-11-20 2019-03-26 Ionis Pharmaceuticals, Inc. Modulation of CD40 expression
WO2011032095A1 (en) * 2009-09-11 2011-03-17 Segetis, Inc. Ketal esters of oxocarboxylic acids and process of making
WO2013120003A1 (en) 2012-02-08 2013-08-15 Isis Pharmaceuticals, Inc. Modulation of rna by repeat targeting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930016437A (en) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 Oligonucleotide Analogues, Methods for Making and Uses thereof
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use

Also Published As

Publication number Publication date
AU2165995A (en) 1995-12-21
CA2628883A1 (en) 1995-12-16
EP0688784B1 (en) 2005-12-14
JPH0827178A (en) 1996-01-30
ES2253740T3 (en) 2006-06-01
AU701333B2 (en) 1999-01-28
DE59511027D1 (en) 2006-01-19
US5696248A (en) 1997-12-09
ATE312840T1 (en) 2005-12-15
EP0688784A3 (en) 1997-01-22
CA2151801C (en) 2008-08-19
EP0688784A2 (en) 1995-12-27
CA2628883C (en) 2011-02-15
DK0688784T3 (en) 2006-04-18
JP4398517B2 (en) 2010-01-13

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150615