CA2154913A1 - Magnetically Responsive Composition for Carrying Biologically Active Substances and Methods of Production and Use - Google Patents

Magnetically Responsive Composition for Carrying Biologically Active Substances and Methods of Production and Use

Info

Publication number
CA2154913A1
CA2154913A1 CA2154913A CA2154913A CA2154913A1 CA 2154913 A1 CA2154913 A1 CA 2154913A1 CA 2154913 A CA2154913 A CA 2154913A CA 2154913 A CA2154913 A CA 2154913A CA 2154913 A1 CA2154913 A1 CA 2154913A1
Authority
CA
Canada
Prior art keywords
biologically active
particles
methods
active substances
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2154913A
Other languages
French (fr)
Other versions
CA2154913C (en
Inventor
Viktor Alexeevich Volkonsky
Sergei V. Chernyakov
Sergei D. Dvuhsherstnov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FeRx Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2154913A1 publication Critical patent/CA2154913A1/en
Application granted granted Critical
Publication of CA2154913C publication Critical patent/CA2154913C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A magnetically controllable, or guided, carrier composition and methods of use and productions are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded ferrocarbon particles of 0.2 to 5.0 µm in size, and preferably between 1.0 and 4.0 µm, containing 1.0 to 95.0% by volume of carbon, and preferably between about 20 and 50%. The particles are produced by a joint deformation of a mechanical mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to absorb the substance onto the particles.
The combination is administered in suspension.
CA002154913A 1993-01-29 1994-01-26 Magnetically responsive composition for carrying biologically active substances and methods of production and use Expired - Fee Related CA2154913C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1136393A 1993-01-29 1993-01-29
US08/011,363 1993-01-29
PCT/US1994/000892 WO1994016683A1 (en) 1993-01-29 1994-01-26 Magnetically responsive composition for carrying biologically active substances and methods of production and use

Publications (2)

Publication Number Publication Date
CA2154913A1 true CA2154913A1 (en) 1994-08-04
CA2154913C CA2154913C (en) 1999-10-19

Family

ID=21750068

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002154913A Expired - Fee Related CA2154913C (en) 1993-01-29 1994-01-26 Magnetically responsive composition for carrying biologically active substances and methods of production and use

Country Status (12)

Country Link
US (3) US5549915A (en)
EP (1) EP0683665B1 (en)
JP (2) JP3145120B2 (en)
AT (1) ATE210967T1 (en)
AU (1) AU6165394A (en)
CA (1) CA2154913C (en)
DE (1) DE69429507T2 (en)
DK (1) DK0683665T3 (en)
ES (1) ES2165385T3 (en)
HK (1) HK1013256A1 (en)
PT (1) PT683665E (en)
WO (1) WO1994016683A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165385T3 (en) * 1993-01-29 2002-03-16 Ferx Inc COMPOSITION SENSITIVE TO THE MAGNETIC FIELD TO TRANSPORT BIOLOGICALLY ACTIVE SUBSTANCES AND METHODS OF PRODUCTION AND USE.
US6200547B1 (en) 1994-01-26 2001-03-13 Ferx Incorporated Magnetically responsive compositions for carrying biologically active substances and methods of production and use
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US7090636B2 (en) * 2000-03-31 2006-08-15 Fe Rx Incorporated Permanent magnet keeper-shield assembly
US6488615B1 (en) 2000-03-31 2002-12-03 Ferx Incorporated Permanent magnet keeper-shield assembly
EP1428228A4 (en) * 2001-02-26 2008-04-30 Univ Utah Res Found Magnetic activated particles for adsorption of solutes from solution
US6921283B2 (en) * 2001-08-27 2005-07-26 Trompeter Electronics, Inc. BNC connector having visual indication
FR2832598B1 (en) * 2001-11-26 2006-01-27 Oreal ARTICLE OF PACKAGING AND / OR APPLICATION OF A PRODUCT
AU2003214812A1 (en) * 2002-01-09 2003-07-30 Ferx Incorporated Magnetic delivery compositions
EP1482956A1 (en) * 2002-02-01 2004-12-08 Vanderbilt University Targeted drug delivery methods
US8097185B2 (en) * 2002-02-26 2012-01-17 University Of Utah Research Foundation Magnetic activated carbon particles for adsorption of solutes from solution
US20040133099A1 (en) * 2002-12-18 2004-07-08 Dyer R. Kent Otologic nanotechnology
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
ES2264839B1 (en) * 2003-11-24 2007-10-01 Universidad De Zaragoza (Inst Denanociencia De Ar Agom. PARENTERAL PHARMACOTHERAPY FOCUSED THROUGH THE IMPLANT OF PERMANENT MAGNETS IN THE DIANA ORGANS.
DE10359252A1 (en) * 2003-12-17 2005-07-28 Siemens Ag Navigated heat treatment of tumors with enzyme-coated iron particles
US20070100457A1 (en) * 2004-03-04 2007-05-03 Hyde Edward R Jr Paramagnetic liquid interface
US20070274907A1 (en) * 2004-03-26 2007-11-29 Yuhua Li Magnetically Targetable Mitomycin C Compositions and Methods of Their Use
US20060024378A1 (en) * 2004-08-02 2006-02-02 Mehta Rakesh H Magnetically responsive carbon nano-structures for transporting biologically active substances, and methods relating thereto
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US8568286B2 (en) * 2006-06-14 2013-10-29 Cardiac Pacemakers, Inc. Methods to position therapeutic agents using a magnetic field
US8246975B2 (en) 2006-06-28 2012-08-21 Ihi Corporation Drug, drug guidance system, magnetic detection system, and drug design method
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
JP5433155B2 (en) * 2008-02-20 2014-03-05 株式会社Ｉｈｉ Magnetic drug, drug guidance system, and magnetic detection device
JP2009274962A (en) * 2008-05-12 2009-11-26 Yoshihiro Ishikawa Iron salen complex, medicine having magnetism, guiding system of medicine and device for detecting magnetism
CN102239138A (en) 2008-11-20 2011-11-09 株式会社Ihi Auto magnetic metal salen complex compound
RU2525509C2 (en) 2009-12-25 2014-08-20 АйЭйчАй КОРПОРЕЙШН Magnetic body and drug delivery control unit using magnetic body
WO2011151978A1 (en) 2010-06-01 2011-12-08 株式会社Ihi Fluorescent dye material and use thereof
US8740872B2 (en) 2010-10-19 2014-06-03 The Board Of Regents Of The University Of Oklahoma Magnetically-targeted treatment for cardiac disorders
US10398668B2 (en) 2010-10-19 2019-09-03 The Board Of Regents Of The University Of Oklahoma Glutamate treatment of cardiovascular disorders
US9744235B2 (en) 2010-10-19 2017-08-29 The Board Of Regents Of The University Of Oklahoma Treatment of cardiovascular disorders with targeted nanoparticles
WO2012086683A1 (en) 2010-12-21 2012-06-28 株式会社Ihi Metal-salen complex compound and production method for same
JP2012176905A (en) * 2011-02-25 2012-09-13 Ihi Corp Metal-salen complex compound
JP2012131737A (en) * 2010-12-21 2012-07-12 Ihi Corp Metal-salen complex compound and production method therefor
JP2012167067A (en) 2011-02-15 2012-09-06 Ihi Corp Auto-magnetic metal salen complex compound
JP5873656B2 (en) 2011-06-13 2016-03-01 株式会社Ihi Metal salen complex compounds, local anesthetics and antineoplastic agents
JP6017766B2 (en) 2011-07-26 2016-11-02 株式会社Ihi Novel anticancer agent of metal salen complex compound
JP6155190B2 (en) 2011-10-04 2017-06-28 株式会社Ihi In-vivo behavior control system of metal-salen complex compound responsive drug and metal-salen complex compound
JP5694549B2 (en) * 2011-10-06 2015-04-01 株式会社Ihi Liquid
SG11201702260RA (en) 2014-09-26 2017-04-27 Ihi Corp Anti-cancer agent and cancer cell killing method

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3718594A (en) * 1970-11-30 1973-02-27 Eastman Kodak Co Method of preparing magnetically responsive carrier particles
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
US4345588A (en) * 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
EP0093757A1 (en) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof
JPS59122429A (en) * 1982-12-28 1984-07-14 Japan Synthetic Rubber Co Ltd Magnetic particle for carrier of biological substance
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
US4849209A (en) * 1985-06-07 1989-07-18 Cadema Medical Products, Inc. Treatment of arthritis, including rheumatoid arthritis with 166 Holmium radionuclide
US4818614A (en) * 1985-07-29 1989-04-04 Shiseido Company Ltd. Modified powder
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US4871716A (en) * 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
JPH01122037U (en) * 1988-02-12 1989-08-18
SU1722256A3 (en) * 1989-11-02 1992-03-23 Viktor A Volkonskij Method of producing magnetically controlled dispersion
ES2165385T3 (en) * 1993-01-29 2002-03-16 Ferx Inc COMPOSITION SENSITIVE TO THE MAGNETIC FIELD TO TRANSPORT BIOLOGICALLY ACTIVE SUBSTANCES AND METHODS OF PRODUCTION AND USE.

Also Published As

Publication number Publication date
DK0683665T3 (en) 2002-04-02
EP0683665A1 (en) 1995-11-29
AU6165394A (en) 1994-08-15
DE69429507T2 (en) 2002-05-16
JPH08506111A (en) 1996-07-02
US5705195A (en) 1998-01-06
JP3145120B2 (en) 2001-03-12
ES2165385T3 (en) 2002-03-16
PT683665E (en) 2002-05-31
EP0683665B1 (en) 2001-12-19
DE69429507D1 (en) 2002-01-31
US5549915A (en) 1996-08-27
EP0683665A4 (en) 1996-04-17
WO1994016683A1 (en) 1994-08-04
CA2154913C (en) 1999-10-19
JP3176600B2 (en) 2001-06-18
JP2001010978A (en) 2001-01-16
US5651989A (en) 1997-07-29
ATE210967T1 (en) 2002-01-15
HK1013256A1 (en) 1999-08-20

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