CA2156721A1 - Removal of Selected Factors from Whole Blood or Its Components - Google Patents

Removal of Selected Factors from Whole Blood or Its Components

Info

Publication number
CA2156721A1
CA2156721A1 CA2156721A CA2156721A CA2156721A1 CA 2156721 A1 CA2156721 A1 CA 2156721A1 CA 2156721 A CA2156721 A CA 2156721A CA 2156721 A CA2156721 A CA 2156721A CA 2156721 A1 CA2156721 A1 CA 2156721A1
Authority
CA
Canada
Prior art keywords
removal
whole blood
components
blood
selected factors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2156721A
Other languages
French (fr)
Other versions
CA2156721C (en
Inventor
Thomas B. Okarma
John Blankenship
Abraham T. Lin
Mohammad A. Elkalay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Thomas B. Okarma
John Blankenship
Abraham T. Lin
Mohammad A. Elkalay
Applied Immune Sciences, Inc.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Aventis Pharmaceuticals Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/032,357 external-priority patent/US5437861A/en
Application filed by Thomas B. Okarma, John Blankenship, Abraham T. Lin, Mohammad A. Elkalay, Applied Immune Sciences, Inc., Rhone-Poulenc Rorer Pharmaceuticals Inc., Aventis Pharmaceuticals Products Inc. filed Critical Thomas B. Okarma
Publication of CA2156721A1 publication Critical patent/CA2156721A1/en
Application granted granted Critical
Publication of CA2156721C publication Critical patent/CA2156721C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3673—Anticoagulant coating, e.g. Heparin coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use

Abstract

This invention provides a composition, device and method for the removal of factors from whole blood or plasma. As shown in the figure, blood enters through line (100) and passes through pump (102). Pump (102) allows the blood to flow through silica bed (104) which has a pressure monitoring device (106) at its inlet and pressure monitoring device (108) at its outlet. The blood is returned to the body through line (110).
CA002156721A 1993-03-16 1994-03-08 Removal of selected factors from whole blood or its components Expired - Fee Related CA2156721C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/032,357 1993-03-16
US08/032,357 US5437861A (en) 1993-03-16 1993-03-16 Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
US20111794A 1994-02-24 1994-02-24
US08/201,117 1994-02-24
PCT/US1994/002541 WO1994021124A1 (en) 1993-03-16 1994-03-08 Removal of selected factors from whole blood or its components

Publications (2)

Publication Number Publication Date
CA2156721A1 true CA2156721A1 (en) 1994-09-29
CA2156721C CA2156721C (en) 1999-06-01

Family

ID=26708317

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002156721A Expired - Fee Related CA2156721C (en) 1993-03-16 1994-03-08 Removal of selected factors from whole blood or its components

Country Status (6)

Country Link
US (1) US5523096A (en)
EP (1) EP0689380A4 (en)
JP (1) JPH09501066A (en)
AU (1) AU680897B2 (en)
CA (1) CA2156721C (en)
WO (1) WO1994021124A1 (en)

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US8329388B2 (en) * 1997-07-30 2012-12-11 Cytosorbents, Inc. Biocompatible devices, systems, and methods for reducing levels of proinflammatory of antiinflammatory stimulators or mediators in the blood
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US6787040B2 (en) * 2000-05-16 2004-09-07 Immunocept, L.L.C. Method and system for colloid exchange therapy
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US7407662B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified viral particles with immunogenic properties and reduced lipid content
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EP1409108A4 (en) * 2001-06-25 2007-11-14 Lipid Sciences Inc Hollow fiber contactor systems for removal of lipids from fluids
US6991727B2 (en) * 2001-06-25 2006-01-31 Lipid Sciences, Inc. Hollow fiber contactor systems for removal of lipids from fluids
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US7393826B2 (en) * 2003-07-03 2008-07-01 Lipid Sciences, Inc. Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
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Also Published As

Publication number Publication date
CA2156721C (en) 1999-06-01
EP0689380A4 (en) 1996-08-14
AU6517694A (en) 1994-10-11
AU680897B2 (en) 1997-08-14
EP0689380A1 (en) 1996-01-03
JPH09501066A (en) 1997-02-04
WO1994021124A1 (en) 1994-09-29
US5523096A (en) 1996-06-04

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