CA2161196A1 - Polymeric composition - Google Patents

Polymeric composition

Info

Publication number
CA2161196A1
CA2161196A1 CA002161196A CA2161196A CA2161196A1 CA 2161196 A1 CA2161196 A1 CA 2161196A1 CA 002161196 A CA002161196 A CA 002161196A CA 2161196 A CA2161196 A CA 2161196A CA 2161196 A1 CA2161196 A1 CA 2161196A1
Authority
CA
Canada
Prior art keywords
polymeric composition
mass
bioabsorbable
occlusive
semipermeable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002161196A
Other languages
French (fr)
Other versions
CA2161196C (en
Inventor
Nagabhushanam Totakura
Shalaby W. Shalaby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Surgical Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2161196A1 publication Critical patent/CA2161196A1/en
Application granted granted Critical
Publication of CA2161196C publication Critical patent/CA2161196C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds

Abstract

A polymeric composition for use in medicine includes a hydrophobic bioabsorbable polymer admixed with a hydrophilic liquid polymer wherein the polymeric composition undergoes macroscopic phase separation on contact with aqueous media. The polymeric composition optionally includes a medicinal agent. The polymeric composition may be deposited as a permeable, semipermeable or occlusive irregular mass, regular mass, film or foam over a suitable surface such viable body tissue. Bioabsorbable implants formed from the polymeric composition may assume a variety of three dimensional configurations such as planar, spherical, cylindrical, rectangular and polygonal.
CA002161196A 1994-11-22 1995-10-23 Polymeric composition Expired - Lifetime CA2161196C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/343,389 US5607686A (en) 1994-11-22 1994-11-22 Polymeric composition
US08/343,389 1994-11-22

Publications (2)

Publication Number Publication Date
CA2161196A1 true CA2161196A1 (en) 1996-05-23
CA2161196C CA2161196C (en) 2005-01-04

Family

ID=23345922

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002161196A Expired - Lifetime CA2161196C (en) 1994-11-22 1995-10-23 Polymeric composition

Country Status (3)

Country Link
US (1) US5607686A (en)
EP (1) EP0713708A1 (en)
CA (1) CA2161196C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015159305A1 (en) 2014-04-13 2015-10-22 Council Of Scientific And Industrial Research Bioactive oil based polyesteramide nanofibers for wound healing applications

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0914102T3 (en) 1996-05-24 2006-01-09 Angiotech Pharm Inc Preparations and methods for treating or preventing diseases of the body canals
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5847046A (en) * 1997-03-12 1998-12-08 United States Surgical Corporation Biodegradable bone cement
ES2359973T3 (en) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES.
GB9814609D0 (en) * 1998-07-07 1998-09-02 Smith & Nephew Polymers
CA2341220A1 (en) 1998-08-20 2000-03-02 3M Innovative Properties Company Spray on bandage and drug delivery system
US6264741B1 (en) * 1998-11-25 2001-07-24 Sandia Corporation Self-assembly of nanocomposite materials
EP2305324B1 (en) 1999-03-25 2014-09-17 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6716445B2 (en) * 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2000060956A1 (en) 1999-04-12 2000-10-19 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6469132B1 (en) * 1999-05-05 2002-10-22 Mcgill University Diblock copolymer and use thereof in a micellar drug delivery system
US6962691B1 (en) 1999-05-20 2005-11-08 U & I Pharmaceuticals Ltd. Topical spray compositions
US20040115252A1 (en) * 1999-06-25 2004-06-17 Thomas Leon Methods of treating illnesses in non-human mammals
KR100416242B1 (en) 1999-12-22 2004-01-31 주식회사 삼양사 Liquid composition of biodegradable block copolymer for drug delivery and process for the preparation thereof
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
EP1315777B1 (en) * 2000-09-06 2007-10-31 AP Pharma, Inc. Degradable polyacetal polymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
CA2451187C (en) * 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7244445B2 (en) 2002-07-29 2007-07-17 Poly Med, Inc Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US20040220534A1 (en) * 2003-04-29 2004-11-04 Martens Paul W. Medical device with antimicrobial layer
WO2005002625A2 (en) 2003-06-26 2005-01-13 Control Delivery Systems, Inc. In-situ gelling drug delivery system
US20050036956A1 (en) * 2003-08-15 2005-02-17 Lin Fei Non-aqueous liquid tooth whitening composition
NZ538805A (en) * 2005-03-14 2007-10-26 Otago Innovation Ltd Site specific intra-oral application apparatus
CA2618404A1 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
WO2007089902A2 (en) * 2006-01-31 2007-08-09 David Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
US8795730B2 (en) * 2006-01-31 2014-08-05 David John Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070265329A1 (en) * 2006-05-12 2007-11-15 Devang Shah T Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
US9555167B2 (en) * 2006-12-11 2017-01-31 3M Innovative Properties Company Biocompatible antimicrobial compositions
US20080200890A1 (en) * 2006-12-11 2008-08-21 3M Innovative Properties Company Antimicrobial disposable absorbent articles
AU2009270695A1 (en) 2008-07-17 2010-01-21 Ap Pharma Methods for enhancing the stability of polyorthoesters and their formulations
US8905760B2 (en) * 2008-11-04 2014-12-09 Duane C. Keller Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations
US8956161B2 (en) 2008-11-04 2015-02-17 Duane C Keller Article and method for controlling oral-originated systemic disease
WO2010068827A1 (en) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Methods for enhancing stability of polyorthoesters and their formulations
US8591229B2 (en) 2010-12-16 2013-11-26 Duane C. Keller Devices and methods for creating a positive pressure environment for treatment of oral biofilms associated with periodontal disease
US8998059B2 (en) 2011-08-01 2015-04-07 Ethicon Endo-Surgery, Inc. Adjunct therapy device having driver with cavity for hemostatic agent
US9492170B2 (en) 2011-08-10 2016-11-15 Ethicon Endo-Surgery, Inc. Device for applying adjunct in endoscopic procedure
US8998060B2 (en) 2011-09-13 2015-04-07 Ethicon Endo-Surgery, Inc. Resistive heated surgical staple cartridge with phase change sealant
US9101359B2 (en) 2011-09-13 2015-08-11 Ethicon Endo-Surgery, Inc. Surgical staple cartridge with self-dispensing staple buttress
US9999408B2 (en) 2011-09-14 2018-06-19 Ethicon Endo-Surgery, Inc. Surgical instrument with fluid fillable buttress
US8814025B2 (en) 2011-09-15 2014-08-26 Ethicon Endo-Surgery, Inc. Fibrin pad matrix with suspended heat activated beads of adhesive
US9254180B2 (en) 2011-09-15 2016-02-09 Ethicon Endo-Surgery, Inc. Surgical instrument with staple reinforcement clip
US9125649B2 (en) 2011-09-15 2015-09-08 Ethicon Endo-Surgery, Inc. Surgical instrument with filled staple
US9198644B2 (en) 2011-09-22 2015-12-01 Ethicon Endo-Surgery, Inc. Anvil cartridge for surgical fastening device
US9393018B2 (en) 2011-09-22 2016-07-19 Ethicon Endo-Surgery, Inc. Surgical staple assembly with hemostatic feature
US8985429B2 (en) 2011-09-23 2015-03-24 Ethicon Endo-Surgery, Inc. Surgical stapling device with adjunct material application feature
US8899464B2 (en) 2011-10-03 2014-12-02 Ethicon Endo-Surgery, Inc. Attachment of surgical staple buttress to cartridge
US9089326B2 (en) 2011-10-07 2015-07-28 Ethicon Endo-Surgery, Inc. Dual staple cartridge for surgical stapler
JPWO2015133580A1 (en) * 2014-03-05 2017-04-06 わかもと製薬株式会社 Injectable polylactic acid-containing composition
US10569071B2 (en) 2015-08-31 2020-02-25 Ethicon Llc Medicant eluting adjuncts and methods of using medicant eluting adjuncts
US10285692B2 (en) * 2015-08-31 2019-05-14 Ethicon Llc Adjuncts for surgical devices including agonists and antagonists
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1109891B (en) * 1955-08-25 1961-06-29 American Sealants Company Liquid mixtures that polymerize in the absence of air
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3763071A (en) * 1969-04-14 1973-10-02 Dow Chemical Co Dispersible suspensions of functional polymers
FR2047874A6 (en) * 1969-06-10 1971-03-19 Nouvel Lucien
US3700643A (en) * 1970-09-02 1972-10-24 Union Carbide Corp Radiation-curable acrylate-capped polycaprolactone compositions
US3760034A (en) * 1971-01-26 1973-09-18 Union Carbide Corp Graft copolymers of lactone polyesters
US3997660A (en) * 1972-02-29 1976-12-14 Ceskoslovenska Akademie Ved Soluble hydrophilic polymers and process for producing the same
US3992518A (en) * 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPS557855A (en) * 1978-07-04 1980-01-21 Nippon Oil & Fats Co Ltd Preparation of non-aqueous polymer dispersion
US4267295A (en) * 1979-02-09 1981-05-12 Syntex (U.S.A.) Inc. Polymeric compositions and hydrogels formed therefrom
DE3027776C2 (en) * 1980-07-23 1982-11-25 Degussa Ag, 6000 Frankfurt Process for the preparation of a (meth) acrylate resin having hydroxyl groups and modified with ε-caprolactone
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US4570629A (en) * 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
US4582052A (en) * 1982-03-23 1986-04-15 Repromed, Inc. Povidone-iodine dispensing fiber
JPH0631602B2 (en) * 1982-04-28 1994-04-27 トヨタ自動車株式会社 Ignition timing control device for internal combustion engine
JPS5911315A (en) * 1982-07-09 1984-01-20 Sumitomo Electric Ind Ltd Compounded composition and thermally recoverable article
US4683287A (en) * 1982-11-02 1987-07-28 Union Carbide Corporation Compositions containing a reactive monomer derived from a lactone
US4543358A (en) * 1982-12-13 1985-09-24 American Cyanamid Company Anthelmintic gel composition and a method for their preparation at ambient temperatures
US5286763A (en) * 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
JPS59190131A (en) * 1983-04-11 1984-10-27 Fuji Giken Kk Paper money paying device
NZ205357A (en) * 1983-05-02 1986-01-24 Stolle Res & Dev A method of treating aquatic plants with a controlled release,biologically active agent containing compositions
US4643734A (en) * 1983-05-05 1987-02-17 Hexcel Corporation Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom
US4883534A (en) * 1983-05-11 1989-11-28 University Of Toronto Innovations Foundations Benzoin antimicrobial dental varnishes
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4725271A (en) * 1983-10-17 1988-02-16 Enquay Pharmaceutical Associates Synthetic resin matrix drug storage and topical drug delivery dressing for veterinary usage
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US4632975A (en) * 1984-02-09 1986-12-30 Union Carbide Corporation Polyfunctional acrylate derivatives of caprolactone-polyols
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
JPS61109637A (en) * 1984-10-31 1986-05-28 Hitachi Ltd Table device
US4701320A (en) * 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
US4650665A (en) * 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4702917A (en) * 1985-11-18 1987-10-27 Research Triangle Institute Porous bioabsorbable polyesters
JPH0759496B2 (en) * 1986-03-25 1995-06-28 ロ−ト製薬株式会社 Periodontal disease treatment agent
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
JPH01500085A (en) * 1986-07-04 1989-01-19 フセソユズニ　ナウチノ‐イススレドバテルスキ　イ　イスピタテルニ　インスティテュト　メディツィンスコイ　テフニキ suture material
US4882168A (en) * 1986-09-05 1989-11-21 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
ES2040719T3 (en) * 1986-09-23 1993-11-01 American Cyanamid Company BIO-ABSORBABLE COATING FOR A SURGICAL ARTICLE.
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4981696A (en) * 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US4983689A (en) * 1987-05-07 1991-01-08 Yu Simon H Process for making macromolecular monomers of polylactones with terminal acryloyl unsaturation and block copolymers thereof
US5175000A (en) * 1987-06-30 1992-12-29 Vipont Pharmaceutical, Inc. Free amine benzophenanthridine alkaloid compositions
US5013553A (en) * 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US4913897A (en) * 1987-12-28 1990-04-03 Bio-Products, Inc. Use of hydrogel solutions to form a hydrophilic protective film on the skin against toxic substances, pollutants, infections and skin secretions
US5068107A (en) * 1988-01-14 1991-11-26 Ortho-Vacon, Inc. Polymeric orthodontic members and orthodontic treatment method
US5160737A (en) * 1988-05-03 1992-11-03 Perio Products Ltd. Liquid polymer composition, and method of use
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5094841A (en) * 1988-07-05 1992-03-10 The Trustees Of Columbia University In The City Of New York Gel for optimum release of fluoride with antibacterial capability for use in the prevention of caries of root surface
DE3825211A1 (en) * 1988-07-25 1990-02-01 Henkel Kgaa IMPROVED BODY RESORBONABLE WAXES (III)
US5068220A (en) * 1988-07-26 1991-11-26 Sharpoint L.P. Biodegradable polyamides for providing a controlled release therapeutic drug
US4950735A (en) * 1988-07-26 1990-08-21 Sharpoint L.P. Biodegradable polyamides
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US4911926A (en) * 1988-11-16 1990-03-27 Mediventures Inc. Method and composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5085866A (en) * 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US4975271A (en) * 1988-12-19 1990-12-04 Vipont Pharmaceutical, Inc. Muscosal delivery systems for treatment of periodontal disease
US5324520A (en) * 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US5236355A (en) 1988-12-22 1993-08-17 American Cyanamid Company Apparatus for the treatment of periodontal disease
DE3905007A1 (en) * 1989-02-18 1990-08-23 Basf Ag CONTINUOUS METHOD FOR PRODUCING AQUEOUS NON-SELF-MULULATING POLYMER DISPERSIONS
US5007940A (en) * 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
SE464109B (en) * 1989-07-06 1991-03-11 Moelnlycke Ab ELASTIC MATERIAL AND ABSORBABLE SINGLE ARTICLES MANUFACTURED THEREOF
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5268178A (en) * 1989-09-25 1993-12-07 The Board Of Regents, The University Of Texas System Biodegradable antibiotic implants and methods of their use in treating and preventing infections
US5093319A (en) * 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
US4994277A (en) * 1989-10-31 1991-02-19 Pfizer Hospital Products Group, Inc. Use of xanthan gum for preventing adhesions
US5133981A (en) * 1989-11-17 1992-07-28 Atrix Laboratories, Inc. Purification of benzophenanthridine alkaloids extracts from alkaloid extracts
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
US5019094A (en) * 1990-05-09 1991-05-28 Ethicon, Inc. Crystalline copolymers of p-dioxanone and poly(alkylene oxides)
US5197882A (en) * 1990-05-14 1993-03-30 Gary R. Jernberg Periodontal barrier and method for aiding periodontal tissue regeneration agents
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
CA2065156A1 (en) * 1990-07-03 1992-01-04 Richard L. Dunn Intragingival delivery systems for treatment of periodontal disease
US5192536A (en) * 1990-10-26 1993-03-09 Huprich Carl A Method and composition for coating a wound with polyether polyurethane
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
DE4206883A1 (en) * 1992-03-05 1993-09-09 Bosch Gmbh Robert FUEL INJECTION PUMP FOR INTERNAL COMBUSTION ENGINES
CA2092646A1 (en) * 1992-03-25 1993-09-26 Ross R. Muth Bioabsorbable blends of a bioabsorbable copolymer and a poly(oxyalkylene)
US5322925A (en) * 1992-10-30 1994-06-21 United States Surgical Corporation Absorbable block copolymers and surgical articles made therefrom
CA2114290C (en) * 1993-01-27 2006-01-10 Nagabushanam Totakura Post-surgical anti-adhesion device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015159305A1 (en) 2014-04-13 2015-10-22 Council Of Scientific And Industrial Research Bioactive oil based polyesteramide nanofibers for wound healing applications

Also Published As

Publication number Publication date
EP0713708A1 (en) 1996-05-29
US5607686A (en) 1997-03-04
CA2161196C (en) 2005-01-04

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