CA2163637A1 - Topologically segregated, encoded solid phase libraries - Google Patents

Topologically segregated, encoded solid phase libraries

Info

Publication number
CA2163637A1
CA2163637A1 CA002163637A CA2163637A CA2163637A1 CA 2163637 A1 CA2163637 A1 CA 2163637A1 CA 002163637 A CA002163637 A CA 002163637A CA 2163637 A CA2163637 A CA 2163637A CA 2163637 A1 CA2163637 A1 CA 2163637A1
Authority
CA
Canada
Prior art keywords
test compound
synthetic test
libraries
molecules
structures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002163637A
Other languages
French (fr)
Other versions
CA2163637C (en
Inventor
Michal Lebl
Kit S. Lam
Sydney E. Salmon
Victor Krchnak
Nikolai Sepetov
Peter Kocis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/249,830 external-priority patent/US5840485A/en
Application filed by Individual filed Critical Individual
Publication of CA2163637A1 publication Critical patent/CA2163637A1/en
Application granted granted Critical
Publication of CA2163637C publication Critical patent/CA2163637C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.
CA002163637A 1993-05-27 1994-05-27 Topologically segregated, encoded solid phase libraries Expired - Fee Related CA2163637C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6832793A 1993-05-27 1993-05-27
US068,327 1993-05-27
US08/249,830 US5840485A (en) 1993-05-27 1994-05-26 Topologically segregated, encoded solid phase libraries
US08/249,830 1994-05-26
PCT/US1994/006078 WO1994028028A1 (en) 1993-05-27 1994-05-27 Topologically segregated, encoded solid phase libraries

Publications (2)

Publication Number Publication Date
CA2163637A1 true CA2163637A1 (en) 1994-12-08
CA2163637C CA2163637C (en) 2008-05-06

Family

ID=26748852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002163637A Expired - Fee Related CA2163637C (en) 1993-05-27 1994-05-27 Topologically segregated, encoded solid phase libraries

Country Status (12)

Country Link
US (1) US6090912A (en)
EP (1) EP0705279B1 (en)
JP (1) JP3394777B2 (en)
AT (2) ATE366741T1 (en)
AU (1) AU686186B2 (en)
CA (1) CA2163637C (en)
DE (2) DE69434998T2 (en)
DK (2) DK1310510T3 (en)
ES (2) ES2204921T3 (en)
NZ (1) NZ267843A (en)
PT (1) PT705279E (en)
WO (1) WO1994028028A1 (en)

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Also Published As

Publication number Publication date
WO1994028028A1 (en) 1994-12-08
DE69432147T2 (en) 2003-11-27
EP0705279A4 (en) 1999-03-24
ATE232882T1 (en) 2003-03-15
DE69434998T2 (en) 2008-03-13
AU686186B2 (en) 1998-02-05
AU7048694A (en) 1994-12-20
ATE366741T1 (en) 2007-08-15
DK1310510T3 (en) 2007-09-24
NZ267843A (en) 1997-10-24
JP3394777B2 (en) 2003-04-07
JPH09501490A (en) 1997-02-10
PT705279E (en) 2003-07-31
EP0705279A1 (en) 1996-04-10
DK0705279T3 (en) 2003-06-10
US6090912A (en) 2000-07-18
CA2163637C (en) 2008-05-06
DE69434998D1 (en) 2007-08-23
ES2204921T3 (en) 2004-05-01
EP0705279B1 (en) 2003-02-19
ES2289194T3 (en) 2008-02-01
DE69432147D1 (en) 2003-03-27

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