CA2164321A1 - Plasma-like solution - Google Patents

Plasma-like solution

Info

Publication number
CA2164321A1
CA2164321A1 CA002164321A CA2164321A CA2164321A1 CA 2164321 A1 CA2164321 A1 CA 2164321A1 CA 002164321 A CA002164321 A CA 002164321A CA 2164321 A CA2164321 A CA 2164321A CA 2164321 A1 CA2164321 A1 CA 2164321A1
Authority
CA
Canada
Prior art keywords
solutions
sodium
partially
subject
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002164321A
Other languages
French (fr)
Other versions
CA2164321C (en
Inventor
Paul E. Segall
Hal Sternberg
Harold D. Waitz
Judith M. Segall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotime Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26752331&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2164321(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/071,533 external-priority patent/US5407428A/en
Application filed by Individual filed Critical Individual
Publication of CA2164321A1 publication Critical patent/CA2164321A1/en
Application granted granted Critical
Publication of CA2164321C publication Critical patent/CA2164321C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Abstract

Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and maguesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
CA002164321A 1993-06-04 1994-06-03 Plasma-like solution Expired - Lifetime CA2164321C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/071,533 1993-06-04
US08/071,533 US5407428A (en) 1993-06-04 1993-06-04 Solutions for use as plasma expanders and substitutes
US13352793A 1993-10-07 1993-10-07
US08/133,527 1993-10-07
PCT/US1994/006279 WO1994028950A1 (en) 1993-06-04 1994-06-03 Plasma-like solution

Publications (2)

Publication Number Publication Date
CA2164321A1 true CA2164321A1 (en) 1994-12-22
CA2164321C CA2164321C (en) 2002-08-20

Family

ID=26752331

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002164321A Expired - Lifetime CA2164321C (en) 1993-06-04 1994-06-03 Plasma-like solution

Country Status (17)

Country Link
US (14) US5702880A (en)
EP (1) EP0701455B1 (en)
JP (1) JP3715312B2 (en)
KR (1) KR100267604B1 (en)
CN (1) CN1102851C (en)
AT (1) ATE199626T1 (en)
AU (1) AU681675B2 (en)
BR (1) BR9406742A (en)
CA (1) CA2164321C (en)
DE (1) DE69426879T2 (en)
DK (1) DK0701455T3 (en)
ES (1) ES2157260T3 (en)
GR (1) GR3036013T3 (en)
HK (1) HK1010698A1 (en)
PT (1) PT701455E (en)
RU (1) RU2142282C1 (en)
WO (1) WO1994028950A1 (en)

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JPH08511265A (en) 1996-11-26
EP0701455A1 (en) 1996-03-20
US5702880A (en) 1997-12-30
WO1994028950A1 (en) 1994-12-22
AU681675B2 (en) 1997-09-04
US5698536A (en) 1997-12-16
EP0701455A4 (en) 1998-01-07
CN1127476A (en) 1996-07-24
DK0701455T3 (en) 2001-06-18
US5733894A (en) 1998-03-31
US5723281A (en) 1998-03-03
US5747071A (en) 1998-05-05
ES2157260T3 (en) 2001-08-16
KR100267604B1 (en) 2000-11-01
US5968726A (en) 1999-10-19
CA2164321C (en) 2002-08-20
US6080538A (en) 2000-06-27
US20020012957A1 (en) 2002-01-31
US5613944A (en) 1997-03-25
GR3036013T3 (en) 2001-09-28
EP0701455B1 (en) 2001-03-14
US6110504A (en) 2000-08-29
CN1102851C (en) 2003-03-12
US6444418B2 (en) 2002-09-03
US5571801A (en) 1996-11-05
US20020025562A1 (en) 2002-02-28
HK1010698A1 (en) 1999-06-25
DE69426879T2 (en) 2001-10-18
US6406839B1 (en) 2002-06-18
US20020009783A1 (en) 2002-01-24
RU2142282C1 (en) 1999-12-10
JP3715312B2 (en) 2005-11-09
US6387612B1 (en) 2002-05-14
US6410218B2 (en) 2002-06-25
BR9406742A (en) 1996-03-12
AU7052594A (en) 1995-01-03
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ATE199626T1 (en) 2001-03-15
PT701455E (en) 2001-09-27

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