CA2164321A1 - Plasma-like solution - Google Patents

Plasma-like solution

Info

Publication number
CA2164321A1
CA2164321A1 CA002164321A CA2164321A CA2164321A1 CA 2164321 A1 CA2164321 A1 CA 2164321A1 CA 002164321 A CA002164321 A CA 002164321A CA 2164321 A CA2164321 A CA 2164321A CA 2164321 A1 CA2164321 A1 CA 2164321A1
Authority
CA
Canada
Prior art keywords
solutions
sodium
partially
subject
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002164321A
Other languages
French (fr)
Other versions
CA2164321C (en
Inventor
Paul E. Segall
Hal Sternberg
Harold D. Waitz
Judith M. Segall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotime Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26752331&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2164321(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/071,533 external-priority patent/US5407428A/en
Application filed by Individual filed Critical Individual
Publication of CA2164321A1 publication Critical patent/CA2164321A1/en
Application granted granted Critical
Publication of CA2164321C publication Critical patent/CA2164321C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Abstract

Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and maguesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
CA002164321A 1993-06-04 1994-06-03 Plasma-like solution Expired - Lifetime CA2164321C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/071,533 US5407428A (en) 1993-06-04 1993-06-04 Solutions for use as plasma expanders and substitutes
US08/071,533 1993-06-04
US13352793A 1993-10-07 1993-10-07
US08/133,527 1993-10-07
PCT/US1994/006279 WO1994028950A1 (en) 1993-06-04 1994-06-03 Plasma-like solution

Publications (2)

Publication Number Publication Date
CA2164321A1 true CA2164321A1 (en) 1994-12-22
CA2164321C CA2164321C (en) 2002-08-20

Family

ID=26752331

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002164321A Expired - Lifetime CA2164321C (en) 1993-06-04 1994-06-03 Plasma-like solution

Country Status (17)

Country Link
US (14) US5702880A (en)
EP (1) EP0701455B1 (en)
JP (1) JP3715312B2 (en)
KR (1) KR100267604B1 (en)
CN (1) CN1102851C (en)
AT (1) ATE199626T1 (en)
AU (1) AU681675B2 (en)
BR (1) BR9406742A (en)
CA (1) CA2164321C (en)
DE (1) DE69426879T2 (en)
DK (1) DK0701455T3 (en)
ES (1) ES2157260T3 (en)
GR (1) GR3036013T3 (en)
HK (1) HK1010698A1 (en)
PT (1) PT701455E (en)
RU (1) RU2142282C1 (en)
WO (1) WO1994028950A1 (en)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3715312B2 (en) * 1993-06-04 2005-11-09 バイオタイム インク Plasma-like solution
US6627393B2 (en) * 1993-06-04 2003-09-30 Biotime, Inc. Solutions for use as plasma expanders and substitutes
US6680305B1 (en) 1993-06-04 2004-01-20 Biotime, Inc. Physiologically acceptable aqueous solutions and methods for their use
US6300322B1 (en) * 1993-06-04 2001-10-09 Biotime, Inc. Plasma-like solution
US5945272A (en) * 1993-06-04 1999-08-31 Biotime, Incorporated Plasma expanders and blood substitutes
US6218099B1 (en) * 1994-06-03 2001-04-17 Biotime, Inc. Methods and compositions for use in perfusion applications
US6040132A (en) * 1996-06-14 2000-03-21 Biostore New Zealand, Ltd. Methods for the lyophilization of living biological materials
US6060233A (en) * 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US5827640A (en) * 1996-06-14 1998-10-27 Biostore New Zealand Limited Methods for the preservation of cells and tissues using trimethylamine oxide or betaine with raffinose or trehalose
US6387069B1 (en) * 1996-09-23 2002-05-14 Dsu Medical Corporation Blood set priming method and apparatus
US7166084B2 (en) * 1996-09-23 2007-01-23 Dsu Medical Corporation Blood set priming method and apparatus
US5804551A (en) * 1996-11-12 1998-09-08 Baxter International Inc. Pretraumatic use of hemoglobin
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6054427A (en) * 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
AU6865298A (en) * 1997-03-17 1998-10-12 Boris Rubinsky The use of cryoprotective agent compounds during cryosurgery
US5834178C1 (en) * 1997-07-09 2002-04-23 Univ Wayne State Flush-storage solution for donor organs
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6117166A (en) * 1997-10-27 2000-09-12 Winston; Thomas R. Apparatus and methods for grafting blood vessel tissue
SK6282000A3 (en) * 1997-10-31 2001-02-12 Biotime Inc Physiologically acceptable aqueous solutions and methods for their use
CN1068778C (en) * 1998-05-15 2001-07-25 赵超英 Novel drug composition for treating and curing and its preparing method
US6706309B1 (en) 1998-11-25 2004-03-16 William F. Aftoora Liquefied water soluble acidity-reducing formulation for food and beverage products
EP1133244A4 (en) * 1998-11-25 2002-04-17 William F Aftoora Liquefied water soluble acidity-reducing formulation for food and beverage products
US6589223B1 (en) 1999-02-03 2003-07-08 Biotime, Inc. Method and compositions for use in perfusion applications
US6755811B1 (en) * 1999-08-25 2004-06-29 Corazon Technologies, Inc. Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue
US6846842B2 (en) 1999-10-07 2005-01-25 Beth Israel Deconess Medical Center, Inc. Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion
US6759230B1 (en) * 1999-10-26 2004-07-06 The Board Of Regents, The University Of Texas Microbe, microbial exopolysaccharide, and uses thereof
US6492103B1 (en) * 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
EP1586329A1 (en) * 2000-02-08 2005-10-19 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US7780967B2 (en) 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
AU2001255339A1 (en) * 2000-04-14 2001-10-30 Biotime, Inc. Systems, kits, and methods of administering synthetic plasma
CA2417331C (en) * 2000-07-28 2011-03-22 Christopher J. Murphy Transplant media comprising bnp-1
AU2002214443B2 (en) * 2000-11-03 2005-12-15 Vitrolife Ab Evaluation and preservation solution
US6746836B1 (en) 2000-12-08 2004-06-08 Abe Widra Alpha-keratose as a blood plasma expander and use thereof
US6806069B2 (en) 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
US6864231B2 (en) * 2001-01-09 2005-03-08 Pharmachem Laboratories, Inc. Glycoprotein matrix compositions and methods related thereto
AU2002254525B2 (en) * 2001-04-04 2004-12-23 Critical Therapeutics, Inc. Method for preventing acute renal failure
US20050053912A1 (en) * 2001-06-11 2005-03-10 Roth Mark B. Methods for inducing reversible stasis
US20070213793A1 (en) * 2001-08-06 2007-09-13 Radiant Medical, Inc. Use of endovascular hypothermia in organ and/or tissue transplantations
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
EP1438085B1 (en) 2001-10-25 2008-10-15 Emory University Catheter for modified perfusion
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
CA2481753A1 (en) * 2002-04-17 2003-10-30 Critical Therapeutics, Inc. Method for treating ileus with an alpha -ketoalkanoic acid or - ester or - amide
JP3912206B2 (en) * 2002-07-05 2007-05-09 株式会社日立製作所 Fuel pump for in-cylinder direct fuel injection system
US20070029259A1 (en) * 2003-02-04 2007-02-08 Hirotaka Kakita Method of reducing impurity content in aqueous salt solution
CN1777416B (en) * 2003-05-01 2012-11-07 伊诺基因卡尔生物技术私人有限公司 Lactate containing pharmaceutical composition and uses thereof
ATE377609T1 (en) * 2004-03-01 2007-11-15 Braun Melsungen Ag HYDROXYETHYL STARCH
GB0407583D0 (en) * 2004-04-05 2004-05-05 Arbab Tarig S M Diagnostic testing and related matters
US7439012B2 (en) * 2004-08-17 2008-10-21 Wake Forest University Health Sciences Ambient stored blood plasma expanders containing keratose
US8465970B2 (en) 2004-10-07 2013-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
EP1827298A4 (en) * 2004-12-22 2011-09-28 Univ Emory Therapeutic adjuncts to enhance the organ protective effects of postconditioning
US7601487B2 (en) * 2005-04-12 2009-10-13 Cleo Cosmetic And Pharmaceutical Co., Llc Composition using HMW dextran and method for in vitro preservation of corneal tissues
EP1879599B1 (en) * 2005-04-20 2013-10-16 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
EP1946763B1 (en) * 2005-11-08 2013-08-21 Ajinomoto Co., Inc. Promoter for recovery from anesthesia
US7854754B2 (en) 2006-02-22 2010-12-21 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
CA2648598A1 (en) * 2006-04-03 2007-10-11 Innogene Kalbiotech Pte Ltd Lactate and calcium containing pharmaceutical composition and uses thereof
IL301141A (en) 2006-04-19 2023-05-01 Transmedics Inc Systems and methods for ex vivo organ care
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
GB0712833D0 (en) * 2007-07-03 2007-08-08 Aqix Ltd Body Fluid Expander
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US8285390B2 (en) 2007-08-21 2012-10-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
US20090123436A1 (en) * 2007-11-08 2009-05-14 Surmodics, Inc. Cryopreservative compositions and methods
US10750738B2 (en) 2008-01-31 2020-08-25 Transmedics, Inc. Systems and methods for ex vivo lung care
US20090263780A1 (en) * 2008-04-17 2009-10-22 Yanming Wang Organ preservation fluid
EP2346428B1 (en) 2008-09-25 2019-11-06 Zeltiq Aesthetics, Inc. Treatment planning systems and methods for body contouring applications
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
CN101444526B (en) * 2008-12-30 2012-06-27 杭州民生药业有限公司 Pharmaceutical composition
ES2916830T3 (en) 2009-04-30 2022-07-06 Zeltiq Aesthetics Inc Device for removing heat from lipid-rich subcutaneous cells
SE534527C2 (en) * 2009-09-24 2011-09-20 Vivoline Medical Ab Procedure, device and fluid for treating a heart after withdrawal
DE102009045589A1 (en) * 2009-10-12 2011-04-14 Universitätsklinikum Freiburg Apparatus for treating an individual with cardiac output, cardiac arrest or stroke
US9314368B2 (en) 2010-01-25 2016-04-19 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods
WO2011160012A1 (en) * 2010-06-17 2011-12-22 The Trustees Of Columbia University In The City Of New York Tissue culture media containing trimethylamine n-oxide
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
IT1401386B1 (en) * 2010-07-30 2013-07-18 Eurotech S P A LIQUID COOLING DEVICE FOR ELECTRONIC BOARDS, IN PARTICULAR FOR HIGH PERFORMANCE PROCESSING UNITS
GB201020300D0 (en) 2010-11-30 2011-01-12 Vitrolife Sweden Ab Product
US10722395B2 (en) 2011-01-25 2020-07-28 Zeltiq Aesthetics, Inc. Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
WO2012125782A2 (en) 2011-03-15 2012-09-20 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
AU2012242578B2 (en) 2011-04-14 2016-07-21 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
CN102488942B (en) * 2011-11-22 2013-03-20 安徽双鹤药业有限责任公司 Blood return testing method and blood return testing device thereof
US20130330706A1 (en) * 2012-06-06 2013-12-12 Evan C. Unger Fluid for Suspended Animation
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US10575890B2 (en) 2014-01-31 2020-03-03 Zeltiq Aesthetics, Inc. Treatment systems and methods for affecting glands and other targeted structures
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
AU2015271799B2 (en) 2014-06-02 2019-07-11 Transmedics, Inc. Ex vivo organ care system
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
EP3229588A4 (en) 2014-12-12 2019-03-13 Freed, Darren Apparatus and method for organ perfusion
CA2988610A1 (en) * 2015-06-10 2016-12-15 Cellphire, Inc. Composition and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia
AU2016308818B2 (en) 2015-08-18 2022-04-21 Astellas Institute For Regenerative Medicine Clinical formulations
CA2997267A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc. Aortic cannula for ex vivo organ care system
US10448631B2 (en) 2015-09-22 2019-10-22 East Carolina University Cryopreservation using sucralose
WO2017070112A1 (en) 2015-10-19 2017-04-27 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
CA3009414A1 (en) 2016-01-07 2017-07-13 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
CN106092848B (en) * 2016-03-22 2018-07-06 威海威高血液净化制品有限公司 Dialyzer ultrafiltration performance test fluid
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
ES2651717B1 (en) * 2016-07-26 2018-11-16 Lara OLLER DUQUE Isotonic crystalloid aqueous solution
EP3551198B1 (en) * 2016-12-08 2022-02-02 Cellphire Inc. Compositions and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
WO2018226993A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
WO2020028472A1 (en) 2018-07-31 2020-02-06 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
US20200208110A1 (en) 2018-11-30 2020-07-02 Cellphire, Inc. PLATELETS LOADED WITH mRNA
EP3886879A4 (en) 2018-11-30 2022-12-07 Cellphire Inc. Platelets as delivery agents
WO2020227149A1 (en) 2019-05-03 2020-11-12 Cellphire, Inc. Materials and methods for producing blood products
AU2020289541A1 (en) 2019-06-03 2021-12-16 Cooler Heads Care, Inc Cooling cap assembly and cooling unit
CN114450066A (en) 2019-08-16 2022-05-06 塞尔菲乐有限公司 Thrombosomes as antiplatelet agent reversal agents
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CA3170201A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
IT202000027050A1 (en) * 2020-11-12 2022-05-12 S A L F S P A Laboratorio Farm COLLOIDAL SOLUTION FOR PERFUSION AND EX-VIVO PRESERVATION OF LUNGS

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34077A (en) * 1862-01-07 Improvement in weighing-registers
US3356570A (en) * 1964-11-27 1967-12-05 Trustees Of Barnes Hospital Composition for treating shock
US3758382A (en) * 1968-07-26 1973-09-11 Us Navy Ve agent process of freezing blood using a hydroxyalkyl starch as cryoprotecti
ZA702706B (en) * 1969-04-28 1971-12-29 Knox Gelatine Inc Blood plasma substitute
US3897550A (en) * 1971-06-01 1975-07-29 Cybersol Method for administering water soluble drugs, nutrients and other solutes to a mammal
US3937821A (en) * 1971-08-21 1976-02-10 Kyorin Seiyaku Kabushiki Kaisha Plasma substitute including artificial starch and method for the preparation thereof
US3949098A (en) * 1974-06-05 1976-04-06 Nabisco, Inc. Nutritious orange drink concentrate, process and drink resultant therefrom
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
DE2801123C2 (en) * 1977-01-26 1986-01-02 Armour Pharma GmbH & Co KG, 3440 Eschwege Process for the production of a serum protein preparation which can be administered intravenously
US4609372A (en) * 1983-10-13 1986-09-02 Miles Laboratories, Inc. Heat sterilizable storage solution for red blood cells
AU583272B2 (en) * 1984-04-27 1989-04-27 Synthetic Blood Corporation Coacervate system synthetic whole blood substitute
AU4634685A (en) * 1984-06-22 1986-01-24 R.L. Veech Electrolyte solutions and in vivo use thereof
US5084377A (en) * 1984-09-19 1992-01-28 Larry Rowan Cryogenic suspension method
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4908350A (en) * 1985-10-31 1990-03-13 The Regents Of The University Of California Hyperosmotic/hyperoncotic solutions for resuscitation of hypodynamic shock
US4769318A (en) * 1986-06-03 1988-09-06 Ube Industries, Ltd. Additive solution for blood preservation and activation
US5210083A (en) * 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
JPS6360931A (en) * 1986-08-29 1988-03-17 Noboru Sato Solution for preserving blood or blood preparation and preservation of blood or blood preparation using said solution
US4927806A (en) * 1987-04-23 1990-05-22 The Regents Of The University Of California Saturated salt/concentrated dextran formulation to treat hemorrhage
AU2900889A (en) * 1987-12-24 1989-07-19 Thomas Julius Borody Orthostatic lavage solutions
US4923442A (en) * 1988-05-02 1990-05-08 Cryomedical Sciences Inc. Blood substitute
US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
USRE34077E (en) * 1988-05-02 1992-09-22 Cryomedical Sciences, Inc. Blood substitute
JPH03220201A (en) * 1988-11-18 1991-09-27 Eisai Co Ltd Conjugate of prostaglandin with polysaccharide
US5252213A (en) * 1989-06-20 1993-10-12 University Of Washington Dry dialysate composition
US5082831A (en) * 1989-12-05 1992-01-21 Cryovita Laboratories, Inc. Total body washout solution and method of use
US5171526A (en) * 1990-01-05 1992-12-15 Allergan, Inc. Ophthalmic compositions and methods for preserving and using same
EP0523037A4 (en) * 1990-03-30 1993-07-28 Biomedical Frontiers, Inc. Fluid resuscitation
US5416078A (en) * 1990-03-30 1995-05-16 Biomedical Frontiers, Inc. Fluid resuscitation
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
GB9021325D0 (en) * 1990-10-01 1990-11-14 Geistlich Soehne Ag Chemical composition
WO1992008349A1 (en) * 1990-11-07 1992-05-29 Baxter International Inc. Blood platelet storage medium
CA2066374C (en) * 1991-04-19 2002-01-29 Paul E. Segall Solution for perfusing primates
EP0663821A4 (en) * 1991-08-08 1997-09-17 Leigh D Segel Fluorocarbon blood substitute.
US5407428A (en) * 1993-06-04 1995-04-18 Biotime, Inc. Solutions for use as plasma expanders and substitutes
JP3715312B2 (en) * 1993-06-04 2005-11-09 バイオタイム インク Plasma-like solution

Also Published As

Publication number Publication date
HK1010698A1 (en) 1999-06-25
ES2157260T3 (en) 2001-08-16
US6387612B1 (en) 2002-05-14
JPH08511265A (en) 1996-11-26
US20020009783A1 (en) 2002-01-24
CA2164321C (en) 2002-08-20
US6110504A (en) 2000-08-29
JP3715312B2 (en) 2005-11-09
EP0701455A4 (en) 1998-01-07
WO1994028950A1 (en) 1994-12-22
US6406839B1 (en) 2002-06-18
CN1102851C (en) 2003-03-12
US5733894A (en) 1998-03-31
US6444418B2 (en) 2002-09-03
ATE199626T1 (en) 2001-03-15
EP0701455A1 (en) 1996-03-20
US5698536A (en) 1997-12-16
US5613944A (en) 1997-03-25
US5968726A (en) 1999-10-19
US6410218B2 (en) 2002-06-25
AU681675B2 (en) 1997-09-04
BR9406742A (en) 1996-03-12
US5747071A (en) 1998-05-05
US20020025562A1 (en) 2002-02-28
EP0701455B1 (en) 2001-03-14
GR3036013T3 (en) 2001-09-28
PT701455E (en) 2001-09-27
US5723281A (en) 1998-03-03
US5702880A (en) 1997-12-30
US6080538A (en) 2000-06-27
DK0701455T3 (en) 2001-06-18
DE69426879T2 (en) 2001-10-18
KR100267604B1 (en) 2000-11-01
CN1127476A (en) 1996-07-24
RU2142282C1 (en) 1999-12-10
US5571801A (en) 1996-11-05
US20020012957A1 (en) 2002-01-31
AU7052594A (en) 1995-01-03
DE69426879D1 (en) 2001-04-19

Similar Documents

Publication Publication Date Title
CA2164321A1 (en) Plasma-like solution
CA2066374A1 (en) Solution for perfusing primates
Arlian et al. Survival and infestivity of Sarcoptes scabiei var. canis and var. hominis
DE3843958C2 (en) Composition for the preservation and storage of an organ transplant and method for its preservation
CN100381048C (en) Evaluation and preservation solution
WO1995002326A1 (en) Solutions for tissue preservation and bloodless surgery and methods using same
EP0142002B1 (en) Heat sterilizable storage solution for red blood cells and blood bags containing it
CA2362051A1 (en) Methods and compositions for use in perfusion applications
Bando et al. Effects of newly developed solutions containing trehalose on twenty-hour canine lung preservation
HUP9900112A2 (en) Preservation solution
Toledo-Pereyra et al. Small bowel preservation: Comparison of perfusion and nonperfusion systems
CA2093116A1 (en) Chemical compositions
JPH0822801B2 (en) Solution for organ preservation
WO1989010746A3 (en) Blood substitute
JP3989574B2 (en) Tooth preservation solution
Takeuchi et al. Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution
JP2770175B2 (en) Kidney protective liquid
Nikonenko et al. Combination of the deportalization of pancreatic blood flow and transplantation of pancreatic islets in patients with insulin dependent diabetes mellitus
Kirklin Historic overview of cardioplegia and reperfusion
Opie Ischemia: Critical lesions
Bolli Myocardial “reperfusion injury”: Fact or fiction?

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140603