CA2165984A1 - Compounds for the photodecontamination of pathogens in blood - Google Patents

Compounds for the photodecontamination of pathogens in blood

Info

Publication number
CA2165984A1
CA2165984A1 CA002165984A CA2165984A CA2165984A1 CA 2165984 A1 CA2165984 A1 CA 2165984A1 CA 002165984 A CA002165984 A CA 002165984A CA 2165984 A CA2165984 A CA 2165984A CA 2165984 A1 CA2165984 A1 CA 2165984A1
Authority
CA
Canada
Prior art keywords
pathogens
compounds
blood
photodecontamination
blood products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002165984A
Other languages
French (fr)
Other versions
CA2165984C (en
Inventor
Susan Wollowitz
Stephen T. Isaacs
Henry Rapoport
Hans Peter Spielmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerus Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2165984A1 publication Critical patent/CA2165984A1/en
Application granted granted Critical
Publication of CA2165984C publication Critical patent/CA2165984C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0066—Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods

Abstract

Psoralen compounds are synthesized which have substitutions on the 4, 4', 5' and 8 positions of the psotalen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
CA002165984A 1993-06-28 1994-06-24 Compounds for the photodecontamination of pathogens in blood Expired - Lifetime CA2165984C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/083,459 1993-06-28
US08/083,459 US5399719A (en) 1993-06-28 1993-06-28 Compounds for the photodecontamination of pathogens in blood
PCT/US1994/007185 WO1995000141A1 (en) 1993-06-28 1994-06-24 Compounds for the photodecontamination of pathogens in blood

Publications (2)

Publication Number Publication Date
CA2165984A1 true CA2165984A1 (en) 1995-01-05
CA2165984C CA2165984C (en) 2004-01-20

Family

ID=22178486

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002165984A Expired - Lifetime CA2165984C (en) 1993-06-28 1994-06-24 Compounds for the photodecontamination of pathogens in blood

Country Status (10)

Country Link
US (6) US5399719A (en)
EP (3) EP1776952A3 (en)
JP (1) JP4047374B2 (en)
AT (2) ATE353643T1 (en)
AU (1) AU699805B2 (en)
CA (1) CA2165984C (en)
DE (3) DE69435250D1 (en)
ES (2) ES2282991T3 (en)
HK (1) HK1083493A1 (en)
WO (1) WO1995000141A1 (en)

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Also Published As

Publication number Publication date
AU7251194A (en) 1995-01-17
EP1584622A2 (en) 2005-10-12
US5399719A (en) 1995-03-21
DE122007000052I1 (en) 2007-11-08
DE69435250D1 (en) 2009-12-24
HK1083493A1 (en) 2006-07-07
US5654443A (en) 1997-08-05
EP0707476B1 (en) 2007-02-14
ES2282991T3 (en) 2007-10-16
DE69434924D1 (en) 2007-03-29
EP0707476A4 (en) 1998-12-23
WO1995000141A1 (en) 1995-01-05
ATE448233T1 (en) 2009-11-15
JP4047374B2 (en) 2008-02-13
EP1584622A3 (en) 2007-10-17
JPH08512032A (en) 1996-12-17
CA2165984C (en) 2004-01-20
EP0707476A1 (en) 1996-04-24
EP1776952A3 (en) 2007-05-02
ATE353643T1 (en) 2007-03-15
US6503699B1 (en) 2003-01-07
DE69434924T2 (en) 2007-11-22
US5972593A (en) 1999-10-26
AU699805B2 (en) 1998-12-17
EP1584622B1 (en) 2009-11-11
US5578736A (en) 1996-11-26
ES2336574T3 (en) 2010-04-14
US5585503A (en) 1996-12-17
EP1776952A2 (en) 2007-04-25

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