CA2166676A1 - Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative - Google Patents

Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative

Info

Publication number
CA2166676A1
CA2166676A1 CA002166676A CA2166676A CA2166676A1 CA 2166676 A1 CA2166676 A1 CA 2166676A1 CA 002166676 A CA002166676 A CA 002166676A CA 2166676 A CA2166676 A CA 2166676A CA 2166676 A1 CA2166676 A1 CA 2166676A1
Authority
CA
Canada
Prior art keywords
derivative
diagnostic agent
copper complex
hypoxia
schiff base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002166676A
Other languages
French (fr)
Other versions
CA2166676C (en
Inventor
Yasuhisa Fujibayashi
Akira Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Publication of CA2166676A1 publication Critical patent/CA2166676A1/en
Application granted granted Critical
Publication of CA2166676C publication Critical patent/CA2166676C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds

Abstract

The present invention relates to a diagnostic agent for hypoxia or mitochondrial dysfunction comprising a radioactive copper complex of a dithiosemicarbazone derivative or a radioactive copper complex of a diamine diol schiff base derivative described in claim 1.
The diagnostic agent according to the present invention has a good transferability to the target tissue, reduction reaction affinity at a hypoxic site, high stability in a non-target site and rapid disappearance ability therefrom.
CA002166676A 1995-01-09 1996-01-05 Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative Expired - Fee Related CA2166676C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1750495 1995-01-09
JP7-17504 1995-01-09

Publications (2)

Publication Number Publication Date
CA2166676A1 true CA2166676A1 (en) 1996-07-10
CA2166676C CA2166676C (en) 2007-05-01

Family

ID=11945820

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166676A Expired - Fee Related CA2166676C (en) 1995-01-09 1996-01-05 Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative

Country Status (9)

Country Link
US (1) US5843400A (en)
EP (1) EP0726077B1 (en)
KR (1) KR100419760B1 (en)
AT (1) ATE210468T1 (en)
AU (1) AU702169B2 (en)
CA (1) CA2166676C (en)
DE (1) DE69617763T2 (en)
DK (1) DK0726077T3 (en)
ES (1) ES2169207T3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11596651B2 (en) 2017-09-01 2023-03-07 Oregon State University Therapeutic metal complexes and ligands and methods of making and using the same

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9705521D0 (en) 1997-03-18 1997-05-07 Univ Sheffield The use of mononuclear phagocytes in the vivo imaging of hypoxic/ischaemic tissue
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
NZ562572A (en) * 2005-04-15 2011-01-28 Synta Pharmaceuticals Corp Combination cancer therapy with BIS (thiohydrazide) amide compounds
GB0513812D0 (en) 2005-07-05 2005-08-10 Isis Innovation Compounds for imaging and therapy
AU2007288338B2 (en) 2006-08-21 2012-05-03 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
JP6017766B2 (en) 2011-07-26 2016-11-02 株式会社Ihi Novel anticancer agent of metal salen complex compound
JP6046338B2 (en) * 2011-10-27 2016-12-14 株式会社Ihi Radical inhibitor
EP2838880B1 (en) * 2012-04-17 2017-12-13 Merrimack Pharmaceuticals, Inc. Compositions and methods for non-invasive imaging
CN109694391B (en) * 2018-12-20 2021-03-23 广西师范大学 Platinum complex taking 2-amino-5-chlorobenzophenone thiosemicarbazone as ligand and synthetic method and application thereof
CN113735781B (en) * 2021-08-18 2023-05-09 广西师范大学 Copper complex and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
JPH01186899A (en) * 1988-01-18 1989-07-26 Nippon Mejifuijitsukusu Kk Tc-99m mononuclear complex having membrane permeability
US4917879A (en) * 1989-05-19 1990-04-17 University Of Cincinnati 99MTC(III) myocardial imaging agents that are effective in humans
US5079346A (en) * 1990-05-01 1992-01-07 Trustees Of The University Of Pennsylvania Gallium-labelled imaging agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11596651B2 (en) 2017-09-01 2023-03-07 Oregon State University Therapeutic metal complexes and ligands and methods of making and using the same

Also Published As

Publication number Publication date
DE69617763D1 (en) 2002-01-24
EP0726077B1 (en) 2001-12-12
EP0726077A2 (en) 1996-08-14
ATE210468T1 (en) 2001-12-15
AU702169B2 (en) 1999-02-18
ES2169207T3 (en) 2002-07-01
CA2166676C (en) 2007-05-01
DK0726077T3 (en) 2002-03-04
DE69617763T2 (en) 2002-08-14
KR100419760B1 (en) 2004-07-05
AU4085696A (en) 1996-07-18
KR960029339A (en) 1996-08-17
US5843400A (en) 1998-12-01
EP0726077A3 (en) 1997-06-11

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Legal Events

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