CA2171638A1 - The semaphorin gene family - Google Patents
The semaphorin gene familyInfo
- Publication number
- CA2171638A1 CA2171638A1 CA002171638A CA2171638A CA2171638A1 CA 2171638 A1 CA2171638 A1 CA 2171638A1 CA 002171638 A CA002171638 A CA 002171638A CA 2171638 A CA2171638 A CA 2171638A CA 2171638 A1 CA2171638 A1 CA 2171638A1
- Authority
- CA
- Canada
- Prior art keywords
- semaphorin
- semaphorins
- nucleic acids
- cell growth
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
- A01K67/0337—Genetically modified Arthropods
- A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/121,713 | 1993-09-13 | ||
US08/121,713 US5639856A (en) | 1993-09-13 | 1993-09-13 | Semaphorin gene family |
PCT/US1994/010151 WO1995007706A1 (en) | 1993-09-13 | 1994-09-13 | The semaphorin gene family |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2171638A1 true CA2171638A1 (en) | 1995-03-23 |
CA2171638C CA2171638C (en) | 2001-05-29 |
Family
ID=22398364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002171638A Expired - Fee Related CA2171638C (en) | 1993-09-13 | 1994-09-13 | The semaphorin gene family |
Country Status (11)
Country | Link |
---|---|
US (8) | US5639856A (en) |
EP (1) | EP0721342B1 (en) |
JP (1) | JP3544378B2 (en) |
AT (1) | ATE214286T1 (en) |
AU (1) | AU683494B2 (en) |
CA (1) | CA2171638C (en) |
DE (1) | DE69430130T2 (en) |
DK (1) | DK0721342T3 (en) |
ES (1) | ES2173922T3 (en) |
PT (1) | PT721342E (en) |
WO (1) | WO1995007706A1 (en) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5654173A (en) * | 1996-08-23 | 1997-08-05 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
DE69637846D1 (en) | 1995-12-06 | 2009-04-09 | Dainippon Sumitomo Pharma Co | NEW SEMAPHORIN Z AND GENE ENCODING IT |
WO1998011216A1 (en) * | 1996-09-11 | 1998-03-19 | Sumitomo Pharmaceuticals Company, Limited | Novel semaphorin gene: semaphorin y |
PT932678E (en) * | 1996-09-24 | 2006-07-31 | Tanox Inc | A family of genes that encode apoptosis-related, peptide-encoded peptides and methods for their use |
US20070299005A1 (en) * | 1996-09-24 | 2007-12-27 | Tanox, Inc. | Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof |
WO1998015628A1 (en) | 1996-10-09 | 1998-04-16 | Sumitomo Pharmaceuticals Company, Limited | Novel semaphorin gene: semaphorin w |
US6436669B1 (en) * | 1996-11-15 | 2002-08-20 | Sumitomo Pharmaceuticals Company, Limited | Semaphorin genes (I) |
EP0892047A3 (en) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Human and murine semaphorin L |
US6428965B1 (en) * | 1997-07-17 | 2002-08-06 | The Johns Hopkins University | Screening assays for the interaction of semaphorins and neuropilins |
US20030166108A1 (en) * | 1997-09-18 | 2003-09-04 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US6130068A (en) | 1998-10-26 | 2000-10-10 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
EP1027436A1 (en) * | 1997-10-28 | 2000-08-16 | Immunex Corporation | Viral encoded semaphorin protein receptor dna and polypeptides |
US7214497B2 (en) | 1997-10-28 | 2007-05-08 | Immunex Corporation | Viral encoded semaphorin protein receptor DNA and polypeptides |
US6562949B1 (en) | 1997-10-28 | 2003-05-13 | Immunex Corporation | Antibodies to viral encoded semaphorin protein receptor polypeptides |
US6635421B1 (en) * | 1997-12-09 | 2003-10-21 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
EP1046650A4 (en) | 1997-12-22 | 2001-12-19 | Ono Pharmaceutical Co | PEPTIDES, METHOD FOR ASSAYING HUMAN PEPSINOGEN II or HUMAN PEPSIN II, AND ASSAYING KIT |
JPH11187882A (en) * | 1997-12-26 | 1999-07-13 | Ono Pharmaceut Co Ltd | Novel polypeptide, its production, cdna coding for the same polypeptide, vector comprising the same cdna, host cell transformed by the same vector, antibody of the same polypeptide, and pharmaceutical composition containing the polypeptide of antibody |
EP0933425A1 (en) * | 1998-01-30 | 1999-08-04 | Smithkline Beecham Plc | Semaphorin family polypeptides and polynucleotides |
EP1066317A2 (en) * | 1998-01-30 | 2001-01-10 | Smithkline Beecham Plc | Novel compounds |
US7339033B2 (en) * | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
EP1135488A1 (en) | 1998-11-26 | 2001-09-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Human semaphorin 6a-1 (sema6a-1), a gene involved in neuronal development and regeneration mechanisms during apoptosis, and its use as a potential drug target |
CA2384104A1 (en) * | 1999-09-08 | 2001-03-15 | Melanie K. Spriggs | Use of semaphorin for modulation of cellular efflux |
US20080213878A1 (en) * | 1999-10-19 | 2008-09-04 | Gregory Donoho | Novel human membrane proteins and polynucleotides encoding the same |
AU1450101A (en) * | 1999-11-02 | 2001-05-14 | Zymogenetics Inc. | Human semaphorin |
WO2001038491A2 (en) * | 1999-11-08 | 2001-05-31 | The General Hospital Corporation | Novel semaphorin domains |
EP1268538A2 (en) * | 2000-03-20 | 2003-01-02 | Lexicon Genetics Incorporated | Human secreted proteins and polynucleotides encoding the same |
WO2001088133A2 (en) * | 2000-05-18 | 2001-11-22 | Lexicon Genetics Incorporated | Human semaphorin homologs and polynucleotides encoding the same |
WO2001090179A2 (en) * | 2000-05-23 | 2001-11-29 | Lexicon Genetics Incorporated | Novel human thrombospondin-like proteins and polynucleotides encoding the same |
DE60130769T2 (en) * | 2000-07-28 | 2008-07-17 | Dainippon Sumitomo Pharma Co., Ltd. | CONVEYORS OF NERVE REGENERATION THAT CONTAIN AN ACTIVE INGREDIENT OF A SEMAPHORINE INHIBITOR |
EP1418834A4 (en) * | 2001-07-20 | 2007-04-04 | Sinai School Medicine | Methods for diagnosing and treating alzheimer's disease and parkinson's disease |
WO2003035100A1 (en) * | 2001-09-26 | 2003-05-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Neuropilin as a novel therapeutic target for modulation of immune reponses |
US7781413B2 (en) * | 2001-10-31 | 2010-08-24 | Board Of Regents, The University Of Texas System | SEMA3B inhibits tumor growth and induces apoptosis in cancer cells |
US20030232419A1 (en) * | 2002-02-04 | 2003-12-18 | Kolodkin Alex L. | Molecules interacting with CASL (MICAL) polynucleotides, polypeptides, and methods of using the same |
EP1442749A1 (en) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system |
FR2876913A1 (en) * | 2004-10-22 | 2006-04-28 | Centre Nat Rech Scient | MODULATION OF SYNAPTIC TRANSMISSION BY SEMAPHORINS AND ITS APPLICATIONS |
WO2008100995A1 (en) | 2007-02-14 | 2008-08-21 | Vaccinex, Inc. | Humanized anti-cd100 antibodies |
KR20170080705A (en) | 2009-05-08 | 2017-07-10 | 백시넥스 인코포레이티드 | Anti-cd100 antibodies and methods for using the same |
JP6395606B2 (en) | 2011-10-11 | 2018-09-26 | バクシネックス インコーポレーティッド | Use of semaphorin-4D binding molecules for regulation of blood brain barrier permeability |
US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
JP6391676B2 (en) * | 2013-05-23 | 2018-09-19 | アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションAjou University Industry−Academic Cooperation Foundation | Tumor penetrating peptide specific for neuropilin and fusion protein fused with this peptide |
PT3013350T (en) | 2013-06-25 | 2020-04-08 | Vaccinex Inc | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases |
NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
EP3262064A1 (en) | 2015-02-23 | 2018-01-03 | Seagull Therapeutics SAS | Non-natural semaphorins 3 and their medical use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2148587C1 (en) * | 1991-06-24 | 2000-05-10 | Чирон Корпорейшн | Polypeptide and method of its synthesis, reagent for immuno-analysis, method of assay of antibody presence, method of induction of immune response |
US5639856A (en) * | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
US5416197A (en) * | 1993-10-15 | 1995-05-16 | Trustees Of The University Of Pennsylvania | Antibodies which bind human collapsin |
US5807806A (en) * | 1997-06-12 | 1998-09-15 | Nippon Soda Co., Ltd. | Benzoylpyrazole derivatives having specific substituents and herbicide |
-
1993
- 1993-09-13 US US08/121,713 patent/US5639856A/en not_active Expired - Lifetime
-
1994
- 1994-09-13 WO PCT/US1994/010151 patent/WO1995007706A1/en active IP Right Grant
- 1994-09-13 AT AT94928057T patent/ATE214286T1/en active
- 1994-09-13 CA CA002171638A patent/CA2171638C/en not_active Expired - Fee Related
- 1994-09-13 EP EP94928057A patent/EP0721342B1/en not_active Expired - Lifetime
- 1994-09-13 AU AU77240/94A patent/AU683494B2/en not_active Ceased
- 1994-09-13 DE DE69430130T patent/DE69430130T2/en not_active Expired - Lifetime
- 1994-09-13 DK DK94928057T patent/DK0721342T3/en active
- 1994-09-13 JP JP50926195A patent/JP3544378B2/en not_active Expired - Fee Related
- 1994-09-13 PT PT94928057T patent/PT721342E/en unknown
- 1994-09-13 ES ES94928057T patent/ES2173922T3/en not_active Expired - Lifetime
-
1997
- 1997-04-08 US US08/833,391 patent/US6013781A/en not_active Expired - Fee Related
- 1997-04-08 US US08/835,268 patent/US5807826A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 US US09/060,610 patent/US6344544B1/en not_active Expired - Fee Related
- 1998-04-15 US US09/060,692 patent/US5935865A/en not_active Expired - Lifetime
-
2002
- 2002-02-04 US US10/067,632 patent/US7153936B2/en not_active Expired - Fee Related
-
2006
- 2006-10-12 US US11/580,373 patent/US20070033669A1/en not_active Abandoned
-
2007
- 2007-06-14 US US11/763,394 patent/US20080312158A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080312158A1 (en) | 2008-12-18 |
AU7724094A (en) | 1995-04-03 |
US6344544B1 (en) | 2002-02-05 |
US6013781A (en) | 2000-01-11 |
EP0721342A4 (en) | 1998-07-29 |
AU683494B2 (en) | 1997-11-13 |
US5807826A (en) | 1998-09-15 |
DK0721342T3 (en) | 2002-07-15 |
US20070033669A1 (en) | 2007-02-08 |
ES2173922T3 (en) | 2002-11-01 |
EP0721342A1 (en) | 1996-07-17 |
CA2171638C (en) | 2001-05-29 |
DE69430130D1 (en) | 2002-04-18 |
US5935865A (en) | 1999-08-10 |
US20030166849A1 (en) | 2003-09-04 |
DE69430130T2 (en) | 2002-08-22 |
EP0721342B1 (en) | 2002-03-13 |
JP3544378B2 (en) | 2004-07-21 |
JPH09505725A (en) | 1997-06-10 |
WO1995007706A1 (en) | 1995-03-23 |
US5639856A (en) | 1997-06-17 |
PT721342E (en) | 2002-09-30 |
ATE214286T1 (en) | 2002-03-15 |
US7153936B2 (en) | 2006-12-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |