CA2172538A1 - Self-setting calcium phosphate cements and methods for preparing and using them - Google Patents

Self-setting calcium phosphate cements and methods for preparing and using them

Info

Publication number
CA2172538A1
CA2172538A1 CA2172538A CA2172538A CA2172538A1 CA 2172538 A1 CA2172538 A1 CA 2172538A1 CA 2172538 A CA2172538 A CA 2172538A CA 2172538 A CA2172538 A CA 2172538A CA 2172538 A1 CA2172538 A1 CA 2172538A1
Authority
CA
Canada
Prior art keywords
calcium phosphate
self
phosphate
preparing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2172538A
Other languages
French (fr)
Other versions
CA2172538C (en
Inventor
Laurence C. Chow
Shozo Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Dental Association Health Foundation
Original Assignee
Laurence C. Chow
Shozo Takagi
American Dental Association Health Foundation
Ada Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurence C. Chow, Shozo Takagi, American Dental Association Health Foundation, Ada Foundation filed Critical Laurence C. Chow
Publication of CA2172538A1 publication Critical patent/CA2172538A1/en
Application granted granted Critical
Publication of CA2172538C publication Critical patent/CA2172538C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
    • A61K6/838—Phosphorus compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/873—Carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Abstract

The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphate other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
CA002172538A 1993-09-24 1994-09-23 Self-setting calcium phosphate cements and methods for preparing and using them Expired - Lifetime CA2172538C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/126,502 US5525148A (en) 1993-09-24 1993-09-24 Self-setting calcium phosphate cements and methods for preparing and using them
US08/126,502 1993-09-24
PCT/US1994/010819 WO1995008319A1 (en) 1993-09-24 1994-09-23 Self-setting calcium phosphate cements and methods for preparing and using them

Publications (2)

Publication Number Publication Date
CA2172538A1 true CA2172538A1 (en) 1995-03-30
CA2172538C CA2172538C (en) 1999-11-16

Family

ID=22425179

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002172538A Expired - Lifetime CA2172538C (en) 1993-09-24 1994-09-23 Self-setting calcium phosphate cements and methods for preparing and using them

Country Status (9)

Country Link
US (4) US5525148A (en)
EP (1) EP0721320B1 (en)
JP (1) JPH10504467A (en)
AT (1) ATE210950T1 (en)
CA (1) CA2172538C (en)
DE (2) DE69429526T2 (en)
ES (1) ES2099687T1 (en)
GR (1) GR970300020T1 (en)
WO (1) WO1995008319A1 (en)

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CA2172538C (en) 1999-11-16
EP0721320A1 (en) 1996-07-17
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US5997624A (en) 1999-12-07
DE69429526T2 (en) 2002-08-08
EP0721320B1 (en) 2001-12-19
US5976234A (en) 1999-11-02
ATE210950T1 (en) 2002-01-15
JPH10504467A (en) 1998-05-06
DE69429526D1 (en) 2002-01-31
US5525148A (en) 1996-06-11
US5954867A (en) 1999-09-21
WO1995008319A1 (en) 1995-03-30
DE721320T1 (en) 1997-04-10
GR970300020T1 (en) 1997-07-30

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