CA2173317A1 - Pharmaceutically acceptable polymeric tissue coating - Google Patents

Pharmaceutically acceptable polymeric tissue coating

Info

Publication number
CA2173317A1
CA2173317A1 CA002173317A CA2173317A CA2173317A1 CA 2173317 A1 CA2173317 A1 CA 2173317A1 CA 002173317 A CA002173317 A CA 002173317A CA 2173317 A CA2173317 A CA 2173317A CA 2173317 A1 CA2173317 A1 CA 2173317A1
Authority
CA
Canada
Prior art keywords
tissues
tissue
cells
polymeric material
binding component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002173317A
Other languages
French (fr)
Other versions
CA2173317C (en
Inventor
Jeffrey A. Hubbell
Donald Elbert
Jennifer L. Hill-West
Paul D. Drumheller
Sanghamitra M. Chowdhury
Amarpreet S. Sawhney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Jeffrey A. Hubbell
Donald Elbert
Jennifer L. Hill-West
Paul D. Drumheller
Sanghamitra M. Chowdhury
Amarpreet S. Sawhney
Board Of Regents, The University Of Texas System
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jeffrey A. Hubbell, Donald Elbert, Jennifer L. Hill-West, Paul D. Drumheller, Sanghamitra M. Chowdhury, Amarpreet S. Sawhney, Board Of Regents, The University Of Texas System, The Board Of Regents Of The University Of Texas System filed Critical Jeffrey A. Hubbell
Publication of CA2173317A1 publication Critical patent/CA2173317A1/en
Application granted granted Critical
Publication of CA2173317C publication Critical patent/CA2173317C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) and which is not poly(ethylene glycol) is used as the non-binding component. A water-soluble polymer that is positively charged at physiological pH (polycation) and which is not poly(L-lysine) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.
CA002173317A 1993-10-05 1994-10-05 Pharmaceutically acceptable polymeric tissue coating Expired - Fee Related CA2173317C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US132,507 1993-10-05
US08/132,507 US5462990A (en) 1990-10-15 1993-10-05 Multifunctional organic polymers
PCT/US1994/011325 WO1995009883A1 (en) 1993-10-05 1994-10-05 Multifunctional organic polymers

Publications (2)

Publication Number Publication Date
CA2173317A1 true CA2173317A1 (en) 1995-04-13
CA2173317C CA2173317C (en) 2007-05-29

Family

ID=22454362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002173317A Expired - Fee Related CA2173317C (en) 1993-10-05 1994-10-05 Pharmaceutically acceptable polymeric tissue coating

Country Status (12)

Country Link
US (4) US5462990A (en)
EP (1) EP0722470B1 (en)
JP (1) JPH09506012A (en)
AT (1) ATE195541T1 (en)
AU (1) AU683312B2 (en)
CA (1) CA2173317C (en)
DE (1) DE69425577T2 (en)
DK (1) DK0722470T3 (en)
ES (1) ES2152334T3 (en)
GR (1) GR3034767T3 (en)
PT (1) PT722470E (en)
WO (1) WO1995009883A1 (en)

Cited By (3)

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US7427415B2 (en) 2002-10-11 2008-09-23 Novocell, Inc. Implantation of encapsulated biological materials for treating diseases
US8802075B2 (en) 2009-02-18 2014-08-12 Eyeon Particle Sciences Llc Bi-functional co-polymer use for opthalmic and other topical and local applications
US11135242B2 (en) 2016-07-06 2021-10-05 Calm Water Therapeutics Llc Bi-functional co-polymer use for ophthalmic and other topical and local applications

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ATE195541T1 (en) 2000-09-15
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US5567440A (en) 1996-10-22
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CA2173317C (en) 2007-05-29
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US5462990A (en) 1995-10-31
US5849839A (en) 1998-12-15
DE69425577D1 (en) 2000-09-21

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