CA2177703A1 - Dry powder inhalator medicament carrier - Google Patents
Dry powder inhalator medicament carrierInfo
- Publication number
- CA2177703A1 CA2177703A1 CA002177703A CA2177703A CA2177703A1 CA 2177703 A1 CA2177703 A1 CA 2177703A1 CA 002177703 A CA002177703 A CA 002177703A CA 2177703 A CA2177703 A CA 2177703A CA 2177703 A1 CA2177703 A1 CA 2177703A1
- Authority
- CA
- Canada
- Prior art keywords
- carrier
- medicament
- depressions
- carrier device
- plan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Abstract
A carrier (10) impregnated at spaced locations along its circumference with a dose (16) of powdered medicament. The powdered medicament is embedded in and across interstices (12) in the carrier formed by intersecting and sometimes offset depressions (32, 34, 36, 38) on each surface of the carrier.
Description
WO 95/1519n PCr~j94/10664 ~1777~3 ;
. DRY POWDER INHA~ATOR MEDICA'.~ENT CARRIER
7.~A~-K':~"UNU OF Tl~7.~ INVENTION
Field of the Invention:
This invention relates to a ~ L carrier, and more particularly, to a carrier containing a dry powder ~ adapted to be housed within an inhalator usable by asthmatics and the like. By 7nh.71 ;ng on a mouthpiece, a prescribed dosage of the r - ~ i ~ 1, is entrained in an air stream and inhaled by the user through the mouthpiece to coat the lungs of the user.
Descri~tion of the Prior A~-t:
Asthma and other respiratory '; co; ~Pc have long been treated by the inhalation of an ~uLu~Liate medicament to coat the bronchial tubes in the lungs to ease breathing and increase air capacity. For many years the two most widely used and convenient choices of treatment have been the inhalation of a - -7iC;r~~ ~
from a drug solution or cl7cponc; on in a metered dose aerosol, ,.~ ~s~uLi2ed inhalator, or in~alation of a powdered drug generally admixed with an excipient, from a dry powder inhalator. Tlith gro:ling concern Wo 95/15190 2 :1 7 7 ~ ~ 3 PCT/US94/10664 : .
being voiced over the strong link between depletion of the earth's a; srh~ric ozone layer and chlorofluorocarbon pm; Cci~,nc, use of these materials in pressurized inhalators is being questioned, while an interest in dry powder inhalation systems has accordingly been stimulated.
Small quantities of a fine particle, preferably micronized powder, are used mainly for therapeutic purposes in treating d;ceAc~c of the respiratory tract. Powders of this type, such as salmeterol hydronapthoate, in quantities generally below 50 mi-;LuU, ~ llh..~ Lg) are added to the respiratory air of the lung of the patient. It has been ~ound that the particles of active materials 6hould have a particle size of less than 5 microns (~) in ~hi~l~nPcc to insure that they penetrate deep into the lung. Thus, the metered dose must be atomized, aerosolized, or sufficiently broken up for inhalation by the patient to achieve the desired effect in the required dosage.
In copPndin~ application serial numbers 08/025,964, ~iled March 3, 1993, to Mlllh Illcor et al, entitled "Dry Powder Inhalator Medicament Carrier", and 08/143,182, filed on or about ûctober 26, 1993, entitled "Dry Powder Medicament Inhalator", by inventors Mulhauser et al, and assigned to the same i~ccignPP as the present invention, a woven or null..Jv~-screen mesh disc or r ~ L carrier is .1; c~ A
which has perforations impregnated at spaced locations ~ WO 9511519n 2 ~ 3 PCIIUS9411066~
;
along its circumference with a dose of powdered r~ Ll such as salmeterol ILy~L~ apLhoate~ which is useful in the LLt:a, L of asthma. The carrier is selectively indexed so as to present the impregnated doses of r - i t seriatim bctween a pair of holes in an upper and lower pressure plate in an inhalator.
Air is forced through the holes in the ~Lc S:.uL~ plates and the perforations in the Pn~r~ ted carrier to entrain a dose of the powdered r-~ Ll which is then inhaled through a mouthpiece, by the patient-user.
Because the powdered r - -;: L is i , _ c y--~,ted into the carrier and spans a number of perforations or interstices formed therein, the air impinging upon the carrier and the powdered r ~ '; ~ L will cause the r~ L to break up as it is pressed up against and passed through the in~ra~LLu~:Lu~ to aerosol or atomize the same so that the r ~ '; ~ L is presented in dy~Lu~Liate particle sizes for maximum benefit when inhaled. Further, due to the porous nature of the carrier and the interstitial deposit of the --';1 L, turbulent air can completely XuLL~u.-d each r~ L dose and entrain it, to assure complete fl;crPnc;n~ of the ~ L dose from the carrier into the air stream. The tllrhlllPn~e can be created in the air flowing through the carrier by passing it through a nozzle and bottom p~S,.uL-- plate in such a manner to create pressure changes resulting in 2 1 7 ~ 7 ~ ~ PCTIUS94/10664 `: ;
turbulence of the air as it passes through the carrier to assist in breaking up the _ ~e ssed dose.
This invention relates to such r-~;cAr ~t carrier structures which lend themselves to mass production.
BRIEF l)ESCRIPTION OF T~E DRAWINGS
Further objects and adv~1.La~es of the invention will become apparent from the following description and claims, and from the AC , ylng drawings, wherein:
FIGURE l :is a top plan view of the dry powder medicament carrier of the present invention;
FIGURE 2 is a perspective view of the carrier disc of FIGURE l;
FIGURE 3 is an enlarged view of one of the lS ~ L doses on the carrier o~ FIGURE
illustrating the structure of a '; c L carrying portion of the carrier;
FIGURE 4 is a cross-sectional view taken substantially along the plane indicated by line 4-4 o~
2 0 FIGURE 3;
~ WO 95/15190 2 1 7 7 7 ~ ~ PCrlUS94110664 .
FIGURE 5 is a fragmentary view similar to FIGURE
. DRY POWDER INHA~ATOR MEDICA'.~ENT CARRIER
7.~A~-K':~"UNU OF Tl~7.~ INVENTION
Field of the Invention:
This invention relates to a ~ L carrier, and more particularly, to a carrier containing a dry powder ~ adapted to be housed within an inhalator usable by asthmatics and the like. By 7nh.71 ;ng on a mouthpiece, a prescribed dosage of the r - ~ i ~ 1, is entrained in an air stream and inhaled by the user through the mouthpiece to coat the lungs of the user.
Descri~tion of the Prior A~-t:
Asthma and other respiratory '; co; ~Pc have long been treated by the inhalation of an ~uLu~Liate medicament to coat the bronchial tubes in the lungs to ease breathing and increase air capacity. For many years the two most widely used and convenient choices of treatment have been the inhalation of a - -7iC;r~~ ~
from a drug solution or cl7cponc; on in a metered dose aerosol, ,.~ ~s~uLi2ed inhalator, or in~alation of a powdered drug generally admixed with an excipient, from a dry powder inhalator. Tlith gro:ling concern Wo 95/15190 2 :1 7 7 ~ ~ 3 PCT/US94/10664 : .
being voiced over the strong link between depletion of the earth's a; srh~ric ozone layer and chlorofluorocarbon pm; Cci~,nc, use of these materials in pressurized inhalators is being questioned, while an interest in dry powder inhalation systems has accordingly been stimulated.
Small quantities of a fine particle, preferably micronized powder, are used mainly for therapeutic purposes in treating d;ceAc~c of the respiratory tract. Powders of this type, such as salmeterol hydronapthoate, in quantities generally below 50 mi-;LuU, ~ llh..~ Lg) are added to the respiratory air of the lung of the patient. It has been ~ound that the particles of active materials 6hould have a particle size of less than 5 microns (~) in ~hi~l~nPcc to insure that they penetrate deep into the lung. Thus, the metered dose must be atomized, aerosolized, or sufficiently broken up for inhalation by the patient to achieve the desired effect in the required dosage.
In copPndin~ application serial numbers 08/025,964, ~iled March 3, 1993, to Mlllh Illcor et al, entitled "Dry Powder Inhalator Medicament Carrier", and 08/143,182, filed on or about ûctober 26, 1993, entitled "Dry Powder Medicament Inhalator", by inventors Mulhauser et al, and assigned to the same i~ccignPP as the present invention, a woven or null..Jv~-screen mesh disc or r ~ L carrier is .1; c~ A
which has perforations impregnated at spaced locations ~ WO 9511519n 2 ~ 3 PCIIUS9411066~
;
along its circumference with a dose of powdered r~ Ll such as salmeterol ILy~L~ apLhoate~ which is useful in the LLt:a, L of asthma. The carrier is selectively indexed so as to present the impregnated doses of r - i t seriatim bctween a pair of holes in an upper and lower pressure plate in an inhalator.
Air is forced through the holes in the ~Lc S:.uL~ plates and the perforations in the Pn~r~ ted carrier to entrain a dose of the powdered r-~ Ll which is then inhaled through a mouthpiece, by the patient-user.
Because the powdered r - -;: L is i , _ c y--~,ted into the carrier and spans a number of perforations or interstices formed therein, the air impinging upon the carrier and the powdered r ~ '; ~ L will cause the r~ L to break up as it is pressed up against and passed through the in~ra~LLu~:Lu~ to aerosol or atomize the same so that the r ~ '; ~ L is presented in dy~Lu~Liate particle sizes for maximum benefit when inhaled. Further, due to the porous nature of the carrier and the interstitial deposit of the --';1 L, turbulent air can completely XuLL~u.-d each r~ L dose and entrain it, to assure complete fl;crPnc;n~ of the ~ L dose from the carrier into the air stream. The tllrhlllPn~e can be created in the air flowing through the carrier by passing it through a nozzle and bottom p~S,.uL-- plate in such a manner to create pressure changes resulting in 2 1 7 ~ 7 ~ ~ PCTIUS94/10664 `: ;
turbulence of the air as it passes through the carrier to assist in breaking up the _ ~e ssed dose.
This invention relates to such r-~;cAr ~t carrier structures which lend themselves to mass production.
BRIEF l)ESCRIPTION OF T~E DRAWINGS
Further objects and adv~1.La~es of the invention will become apparent from the following description and claims, and from the AC , ylng drawings, wherein:
FIGURE l :is a top plan view of the dry powder medicament carrier of the present invention;
FIGURE 2 is a perspective view of the carrier disc of FIGURE l;
FIGURE 3 is an enlarged view of one of the lS ~ L doses on the carrier o~ FIGURE
illustrating the structure of a '; c L carrying portion of the carrier;
FIGURE 4 is a cross-sectional view taken substantially along the plane indicated by line 4-4 o~
2 0 FIGURE 3;
~ WO 95/15190 2 1 7 7 7 ~ ~ PCrlUS94110664 .
FIGURE 5 is a fragmentary view similar to FIGURE
3, but illustrating a dir~erent configuration of the pel~oLations or interstices for holding the ~ L
on the carrier;
FIGURE 6 is a cross-~c~ionAl view taken substantially along the plane indicated by line 6-6 of FIGURE 5;
FIGURE 7 is a fragmentary view similar to FIGURE
3, but illustrating a further different configuration of the interstices which can be used for holding the "; ~ L on the carrier;
FIGURE 8 is a cross-sectional view taken substAnt;Ally along the plane indicated by line 8-8 of FIGURE 7;
- FIGURE 9 is a fragmentary view similar to FIGURE
3, but illustrating yet another conf iguration of the interstices for holding the - ';I L on the carrier;
FIGURE lO is a cross-sectional view taken substantially along the plane indicated by line lO-lO
of FIGURE 9;
FIGURE ll is a fragmentary view similar to FIGURE
3, but illustrating still a different configuration of the interstices for holding the r-a;~ -- L on the carrier;
-FIGURE 12 is a cross-sectional view taken substantially along the plane indicated by line 12-12 of FIGURE 11.
DE'T~TT~n DESCRIPTION OF THE ~K~ MP~nDIMENT
Referring now to the drawings in detail, wherein like numeral6 indicate like elements thluuy~lOuL the several views, a medicament carrier 10 in the shape of a ring or disc is illustrated in FIG. 1 which constitutes a r~ L carrier forming the subject of the instant invention.
The medicament carrier 10 is of a size to be inserted within a breath-activated dry powder inhalator disclosed in detail in copc~n~; n~ U. 5 .
application, Serial No. 08/143,182, filed on or ~bout October 26, 1993, to M~llhAll-er et al, entitled "Dry Powder M~-l; L Inhalator" and Ac~ci~npd to the same Acc;~n-~e as the present invention, which disclosure is in~ uL~olc.Led by reference herein.
The carrier 10 can be stamped from a metal blank or even photo acid etched from St~inlPcc steel or ceramic to provide portions adjacent its periphery 14 containing a plurality of small interstices 12 (see e.g., FIGS. 3 and 4). Disposed across and impregnated within a number of the interstices 12 by ~h~cif~n at spaeed locations along the periphery or eircumference ~ WO 95/l5190 2 1 7 7 ~ ~ ~ PCrJUS9~11066~
;
14 of the carrier 10 is a prescribed dose 16 of a - ~ '; t ~. The size of the dose 16 depends upon the drug used. For example, a common drug used for asthmatics is fiAlr ' Prol l.ydLul-a~Lhoate which is to be ~ pPnc:pd in single doses of approximately 50 mi iLUyLa~. Each 'il 1, dose 16 of this drug could be approximately .030 to .250 inches in ~
with a fh;(~knP~: of about .002 - 0.1 inches to achieve the effective dosage.
The carrier 10 can be formed with interstice6 12 of approximately . 004 to .125 square inches and is positioned between a pair of ~LI=aaUL~: plates (not shown) each having an enlarged opening adapted to register with one of the r ~ ' i ~ I_ doses 16 upon inrlPYin7 of the carrier 10, by suitable - '-n;cAl means, such as a pawl in contact with s~olPted camming teeth 22 on the inner ring or ciL iiu~Le~ e of the carrier. Indicia 24 adjacent teeth 22 will indicate to the user the number of doses 16 1, ;n;n~ on the carrier 10. The ~res,,uLe plates distribute the pressure about the pprirhpry of the carrier 10 to maintain the - 'i~ ~ dose 16 in its i _ eg..a~ed position ~ssed across the interstices or perforations 12 and the 6pace th~L~ bc L~ l adjacent the periphery 14. Air can then be forced through the plate holes and the Pn~ rS~ ted carrier 10 to entrain the dose 16 of the powdered - ';CA- l~, and the air stream with the entrained r - ' i: ~ ~ is then inhaled through a mouthpiece by the patient-user.
Wo 95/15190 2 ~ 7 ~ ~ ~ 3 PCT/US9~/1066 4 Because the powdered --- - i, L is ; _ ey,.ated into the carrier 10, across a plurali~y of the interstices 12, the air impinging upon the carrier disc and the powdered r~ L will cause the medicament to break up as it is pressed up against and passed through the disc infrastructure or interstices 12 in the carrier 10 to aerosol or atomize the same 80 that the ~ L is presented in appropriate particle sizes for maximum benefit when inhaled.
Further, due to the porous nature of the carrier and the interstitial deposit of the r-';l L, air can let~ly ~ULL~UIId each ';~ L dose and entrain it as shown e . g ., in FIG. 3 to ~ssure complete ~1;cp~nc;nq o~ the medicament dose from the mesh into the air stream.
As shown in FIGS. 3 and 4, the dose carrying portion 16 of the carrier disc 10 can be formed by photoetching or stamping of a metal or ceramic base 26 from opposite sides 28, 30 of the base with overlapping and offset, intersecting, cup-shaped depressions 32 for aiding in holding the ';~ ~ 13 on the surface of carrier 10. Three adjacent ones of cup-shaped depressions 32, e.g., 34, 36, and 38, form a set of the interstices 12, each of substantially ovoid shape in plan. The overlapping portions 40 of the cup-shaped depressions 32 form an air passage (or interstice 12) and provide corner surfaces 42 for contact with the r-~ as it is entrained in the WO 9S/15190 2 ~ 7 7 7 0 ~ PCrlUS9111066,1 ;
air to aid in pressing against the '; ~ L and breaking up the same to ensure complete entrainment and minimal agglomeration of the r-';( L particles.
FIGS. 5 and 6 illustrate that in lieu of forming cup-shaped depressions which overlap and are offset from each other, the cup-shaped depressions 44 formed on each surface or side 28, 30 of the base 26 can intersect along a common axis, still providing corner surfaces 46 for contact with the ~ L to aid in breaking upon the -~1~ L when entrained in an air stream through the aligned depressions.
FIGS. 7 and 8 show that the cup-shaped depressions 51 rather than being circular in plan, as in FIGS. 3 and 5, can be square in plan forming sguare overlapping and intersecting of fset interstices 48 .
In FIGS. 9 and 10, the cup-shaped depressions 52 are hexagonal in plan on both surfaces 28 and 30 of base 2 6, providing diamond shaped interstices 54 at intersecting corners of the depressions. The interstices 48 and 54 have defined, sharp corners 53, along with the depressions 51 and 52 to increase contact with the medicament during air flow to ensure that the ~ l~ ssed dose 16 is broken up.
WO 95/15190 PCT/US94/l066~
~1777~3 lo The cup-shaped depressions 56 may also be formed with different diameters, as illustrated in FIGS. 11 and 12 and need not be offset, as in FIGS. 5 and 6, as long as interfering surfaces 58 are formed for contact 5 with the entrained ~ -nt dose 16.
on the carrier;
FIGURE 6 is a cross-~c~ionAl view taken substantially along the plane indicated by line 6-6 of FIGURE 5;
FIGURE 7 is a fragmentary view similar to FIGURE
3, but illustrating a further different configuration of the interstices which can be used for holding the "; ~ L on the carrier;
FIGURE 8 is a cross-sectional view taken substAnt;Ally along the plane indicated by line 8-8 of FIGURE 7;
- FIGURE 9 is a fragmentary view similar to FIGURE
3, but illustrating yet another conf iguration of the interstices for holding the - ';I L on the carrier;
FIGURE lO is a cross-sectional view taken substantially along the plane indicated by line lO-lO
of FIGURE 9;
FIGURE ll is a fragmentary view similar to FIGURE
3, but illustrating still a different configuration of the interstices for holding the r-a;~ -- L on the carrier;
-FIGURE 12 is a cross-sectional view taken substantially along the plane indicated by line 12-12 of FIGURE 11.
DE'T~TT~n DESCRIPTION OF THE ~K~ MP~nDIMENT
Referring now to the drawings in detail, wherein like numeral6 indicate like elements thluuy~lOuL the several views, a medicament carrier 10 in the shape of a ring or disc is illustrated in FIG. 1 which constitutes a r~ L carrier forming the subject of the instant invention.
The medicament carrier 10 is of a size to be inserted within a breath-activated dry powder inhalator disclosed in detail in copc~n~; n~ U. 5 .
application, Serial No. 08/143,182, filed on or ~bout October 26, 1993, to M~llhAll-er et al, entitled "Dry Powder M~-l; L Inhalator" and Ac~ci~npd to the same Acc;~n-~e as the present invention, which disclosure is in~ uL~olc.Led by reference herein.
The carrier 10 can be stamped from a metal blank or even photo acid etched from St~inlPcc steel or ceramic to provide portions adjacent its periphery 14 containing a plurality of small interstices 12 (see e.g., FIGS. 3 and 4). Disposed across and impregnated within a number of the interstices 12 by ~h~cif~n at spaeed locations along the periphery or eircumference ~ WO 95/l5190 2 1 7 7 ~ ~ ~ PCrJUS9~11066~
;
14 of the carrier 10 is a prescribed dose 16 of a - ~ '; t ~. The size of the dose 16 depends upon the drug used. For example, a common drug used for asthmatics is fiAlr ' Prol l.ydLul-a~Lhoate which is to be ~ pPnc:pd in single doses of approximately 50 mi iLUyLa~. Each 'il 1, dose 16 of this drug could be approximately .030 to .250 inches in ~
with a fh;(~knP~: of about .002 - 0.1 inches to achieve the effective dosage.
The carrier 10 can be formed with interstice6 12 of approximately . 004 to .125 square inches and is positioned between a pair of ~LI=aaUL~: plates (not shown) each having an enlarged opening adapted to register with one of the r ~ ' i ~ I_ doses 16 upon inrlPYin7 of the carrier 10, by suitable - '-n;cAl means, such as a pawl in contact with s~olPted camming teeth 22 on the inner ring or ciL iiu~Le~ e of the carrier. Indicia 24 adjacent teeth 22 will indicate to the user the number of doses 16 1, ;n;n~ on the carrier 10. The ~res,,uLe plates distribute the pressure about the pprirhpry of the carrier 10 to maintain the - 'i~ ~ dose 16 in its i _ eg..a~ed position ~ssed across the interstices or perforations 12 and the 6pace th~L~ bc L~ l adjacent the periphery 14. Air can then be forced through the plate holes and the Pn~ rS~ ted carrier 10 to entrain the dose 16 of the powdered - ';CA- l~, and the air stream with the entrained r - ' i: ~ ~ is then inhaled through a mouthpiece by the patient-user.
Wo 95/15190 2 ~ 7 ~ ~ ~ 3 PCT/US9~/1066 4 Because the powdered --- - i, L is ; _ ey,.ated into the carrier 10, across a plurali~y of the interstices 12, the air impinging upon the carrier disc and the powdered r~ L will cause the medicament to break up as it is pressed up against and passed through the disc infrastructure or interstices 12 in the carrier 10 to aerosol or atomize the same 80 that the ~ L is presented in appropriate particle sizes for maximum benefit when inhaled.
Further, due to the porous nature of the carrier and the interstitial deposit of the r-';l L, air can let~ly ~ULL~UIId each ';~ L dose and entrain it as shown e . g ., in FIG. 3 to ~ssure complete ~1;cp~nc;nq o~ the medicament dose from the mesh into the air stream.
As shown in FIGS. 3 and 4, the dose carrying portion 16 of the carrier disc 10 can be formed by photoetching or stamping of a metal or ceramic base 26 from opposite sides 28, 30 of the base with overlapping and offset, intersecting, cup-shaped depressions 32 for aiding in holding the ';~ ~ 13 on the surface of carrier 10. Three adjacent ones of cup-shaped depressions 32, e.g., 34, 36, and 38, form a set of the interstices 12, each of substantially ovoid shape in plan. The overlapping portions 40 of the cup-shaped depressions 32 form an air passage (or interstice 12) and provide corner surfaces 42 for contact with the r-~ as it is entrained in the WO 9S/15190 2 ~ 7 7 7 0 ~ PCrlUS9111066,1 ;
air to aid in pressing against the '; ~ L and breaking up the same to ensure complete entrainment and minimal agglomeration of the r-';( L particles.
FIGS. 5 and 6 illustrate that in lieu of forming cup-shaped depressions which overlap and are offset from each other, the cup-shaped depressions 44 formed on each surface or side 28, 30 of the base 26 can intersect along a common axis, still providing corner surfaces 46 for contact with the ~ L to aid in breaking upon the -~1~ L when entrained in an air stream through the aligned depressions.
FIGS. 7 and 8 show that the cup-shaped depressions 51 rather than being circular in plan, as in FIGS. 3 and 5, can be square in plan forming sguare overlapping and intersecting of fset interstices 48 .
In FIGS. 9 and 10, the cup-shaped depressions 52 are hexagonal in plan on both surfaces 28 and 30 of base 2 6, providing diamond shaped interstices 54 at intersecting corners of the depressions. The interstices 48 and 54 have defined, sharp corners 53, along with the depressions 51 and 52 to increase contact with the medicament during air flow to ensure that the ~ l~ ssed dose 16 is broken up.
WO 95/15190 PCT/US94/l066~
~1777~3 lo The cup-shaped depressions 56 may also be formed with different diameters, as illustrated in FIGS. 11 and 12 and need not be offset, as in FIGS. 5 and 6, as long as interfering surfaces 58 are formed for contact 5 with the entrained ~ -nt dose 16.
Claims (12)
1. A medicament carrier device for use in a dry powder breath-activated inhalator apparatus comprising a carrier having opposed surfaces comprising overlapping and intersecting depressions, with a plurality of said interstices formed from and joining portions of said overlapping, intersecting depressions formed in each of said opposed surfaces, at least one predetermined dose of a powdered medicament impregnated within said carrier, said powdered medicament dose disposed on at least one portion of said opposed surfaces of said carrier across said portion, said powdered medicament contained within said depressions forming said plurality of interstices and spanning the spaces between said depressions;
non-intersecting portions of said depressions also holding said powdered medicament and providing sharp edges, said sharp edges atomizing said powdered medicament responsive to air flowing through said carrier, depressions, and interstices, and impinging on said sharp edges, said powdered medicament being entrained within this flow of air introduced into said carrier .
non-intersecting portions of said depressions also holding said powdered medicament and providing sharp edges, said sharp edges atomizing said powdered medicament responsive to air flowing through said carrier, depressions, and interstices, and impinging on said sharp edges, said powdered medicament being entrained within this flow of air introduced into said carrier .
2. The medicament carrier device of claim 1 wherein said depressions in each of said opposed surfaces have the same geometric shape in plan, but are offset from each other along a vertical axis through each of said intersecting depressions.
3. The medicament carrier device of claim 1 wherein said depressions in each of said opposed surfaces have the same geometric shape in plan, and are formed along a common vertical axis through each of said intersecting depressions.
4. The medicament carrier device of claim 3 wherein said depressions in each of said opposed surfaces have the same geometric shape in plan, but are of different sizes.
5. The medicament carrier device of claim 2 wherein said geometric shape in plan is a circle.
6. The medicament carrier device of claim 2 wherein said geometric shape in plan is a square.
7. The medicament carrier device of claim 2 wherein said geometric shape in plan is a hexagon.
8. The medicament carrier device of claim 1 wherein said carrier is formed from metal and said depressions are photo-etched in said metal.
9. The medicament carrier device of claim 1 wherein said carrier is formed from metal and said depressions are stamped in said metal carrier.
10. The medicament carrier device of claim 1 wherein said carrier is formed from a ceramic material.
11. The medicament carrier device of claim 7 wherein said interstices are approximately . 004 to .125 square inches in area.
12. The medicament carrier device of claim 9 wherein each said medicament dose on said carrier is approximately .030 to .250 inches in diameter with a thickness of about .002 to 0.1 inches.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/161,230 US5388573A (en) | 1993-12-02 | 1993-12-02 | Dry powder inhalator medicament carrier |
| US08/161,230 | 1993-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2177703A1 true CA2177703A1 (en) | 1995-06-08 |
Family
ID=22580378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002177703A Abandoned CA2177703A1 (en) | 1993-12-02 | 1994-09-21 | Dry powder inhalator medicament carrier |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5388573A (en) |
| EP (1) | EP0792175B1 (en) |
| JP (1) | JP3573212B2 (en) |
| KR (1) | KR960706360A (en) |
| CN (1) | CN1143915A (en) |
| AT (1) | ATE209516T1 (en) |
| AU (1) | AU687101B2 (en) |
| BR (1) | BR9408206A (en) |
| CA (1) | CA2177703A1 (en) |
| DE (1) | DE69429286T2 (en) |
| FI (1) | FI962272A0 (en) |
| HU (1) | HU216507B (en) |
| NO (1) | NO962265L (en) |
| NZ (1) | NZ274378A (en) |
| WO (1) | WO1995015190A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007115395A1 (en) * | 2006-04-07 | 2007-10-18 | The University Of Western Ontario | Powder inhaler featuring disc with dosing holes |
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| US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
| DE4142238A1 (en) * | 1991-12-20 | 1993-06-24 | Boehringer Ingelheim Kg | POWDER INHALATOR WITH POWDER SUPPORT FROM REGULAR MICROSTRUCTURES |
| JPH08507452A (en) * | 1993-03-03 | 1996-08-13 | テナックス コーポレーション | Dry powder inhaler drug carrier |
| US5647347A (en) * | 1994-10-21 | 1997-07-15 | Glaxo Wellcome Inc. | Medicament carrier for dry powder inhalator |
| US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
| US5699789A (en) * | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
| US5875776A (en) * | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| GB9610821D0 (en) * | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US5794613A (en) * | 1997-01-09 | 1998-08-18 | Sepracor, Inc. | Multiple-dose dispenser for dry powder inhalers |
| US6006747A (en) | 1997-03-20 | 1999-12-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| JP4221859B2 (en) * | 1999-02-12 | 2009-02-12 | 株式会社デンソー | Manufacturing method of semiconductor device |
| SE524957C2 (en) * | 2002-04-12 | 2004-11-02 | Microdrug Ag | Method for dividing and distributing in air of dry powder drug |
| SE524990C2 (en) * | 2002-04-12 | 2004-11-09 | Microdrug Ag | Preparation of therapeutic dry powder and method for splitting and spreading in the air of medical powder |
| SE525027C2 (en) * | 2002-04-12 | 2004-11-16 | Microdrug Ag | Device comprising a powder air grinder |
| US8251060B2 (en) * | 2006-11-15 | 2012-08-28 | Perfetti and Perfetti, LLC | Device and method for delivering an aerosol drug |
| USD635246S1 (en) * | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
| US9351924B2 (en) | 2011-03-11 | 2016-05-31 | Snu R&Db Foundation | Drug delivery system including laminated structure |
| US9016274B1 (en) | 2013-10-14 | 2015-04-28 | Jackie L. White | Devices for vaporizing and delivering an aerosol agent |
| US10765821B2 (en) * | 2015-03-19 | 2020-09-08 | Altria Client Services Llc | Vaporizer for vaporizing a constituent of a plant material |
| US10179215B2 (en) | 2015-03-19 | 2019-01-15 | Altria Client Services Llc | Vaporizer for vaporizing a constituent of a plant material |
| US10292431B2 (en) | 2016-07-18 | 2019-05-21 | Jackie L. White | Pellet substrates for vaporizing and delivering an aerosol |
| US10624386B2 (en) | 2017-07-18 | 2020-04-21 | Jackie L. White | Pellet substrates for vaporizing and delivering an aerosol |
| USD916361S1 (en) | 2019-06-25 | 2021-04-13 | Altria Client Services Llc | Aerosol-generating capsule |
| US11458262B2 (en) | 2019-06-25 | 2022-10-04 | Altria Client Services Llc | Capsules, heat-not-burn (HNB) aerosol-generating devices, and methods of generating an aerosol |
| US11910826B2 (en) | 2021-01-18 | 2024-02-27 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices and capsules |
| US11789476B2 (en) | 2021-01-18 | 2023-10-17 | Altria Client Services Llc | Heat-not-burn (HNB) aerosol-generating devices including intra-draw heater control, and methods of controlling a heater |
| US11510870B1 (en) | 2021-08-31 | 2022-11-29 | Jackie L. White | Substrates for vaporizing and delivering an aerosol |
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-
1993
- 1993-12-02 US US08/161,230 patent/US5388573A/en not_active Expired - Lifetime
-
1994
- 1994-09-21 HU HU9601485A patent/HU216507B/en not_active IP Right Cessation
- 1994-09-21 CN CN94194825A patent/CN1143915A/en active Pending
- 1994-09-21 AT AT94929275T patent/ATE209516T1/en not_active IP Right Cessation
- 1994-09-21 JP JP51559395A patent/JP3573212B2/en not_active Expired - Fee Related
- 1994-09-21 WO PCT/US1994/010664 patent/WO1995015190A1/en active IP Right Grant
- 1994-09-21 EP EP94929275A patent/EP0792175B1/en not_active Expired - Lifetime
- 1994-09-21 NZ NZ274378A patent/NZ274378A/en not_active IP Right Cessation
- 1994-09-21 KR KR1019960702891A patent/KR960706360A/en active IP Right Grant
- 1994-09-21 CA CA002177703A patent/CA2177703A1/en not_active Abandoned
- 1994-09-21 DE DE69429286T patent/DE69429286T2/en not_active Expired - Lifetime
- 1994-09-21 AU AU78393/94A patent/AU687101B2/en not_active Ceased
- 1994-09-21 BR BR9408206A patent/BR9408206A/en not_active IP Right Cessation
-
1996
- 1996-05-30 FI FI962272A patent/FI962272A0/en unknown
- 1996-05-31 NO NO962265A patent/NO962265L/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007115395A1 (en) * | 2006-04-07 | 2007-10-18 | The University Of Western Ontario | Powder inhaler featuring disc with dosing holes |
Also Published As
| Publication number | Publication date |
|---|---|
| NO962265D0 (en) | 1996-05-31 |
| NO962265L (en) | 1996-07-31 |
| JPH09509853A (en) | 1997-10-07 |
| US5388573A (en) | 1995-02-14 |
| AU7839394A (en) | 1995-06-19 |
| HUT75136A (en) | 1997-04-28 |
| DE69429286D1 (en) | 2002-01-10 |
| JP3573212B2 (en) | 2004-10-06 |
| DE69429286T2 (en) | 2002-07-18 |
| HU216507B (en) | 1999-07-28 |
| EP0792175B1 (en) | 2001-11-28 |
| CN1143915A (en) | 1997-02-26 |
| WO1995015190A1 (en) | 1995-06-08 |
| AU687101B2 (en) | 1998-02-19 |
| NZ274378A (en) | 1998-01-26 |
| FI962272A (en) | 1996-05-30 |
| EP0792175A4 (en) | 1997-09-03 |
| FI962272A0 (en) | 1996-05-30 |
| ATE209516T1 (en) | 2001-12-15 |
| EP0792175A1 (en) | 1997-09-03 |
| BR9408206A (en) | 1997-08-26 |
| KR960706360A (en) | 1996-12-09 |
| HU9601485D0 (en) | 1996-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |