CA2183875A1 - Electrotransport drug delivery device - Google Patents
Electrotransport drug delivery deviceInfo
- Publication number
- CA2183875A1 CA2183875A1 CA002183875A CA2183875A CA2183875A1 CA 2183875 A1 CA2183875 A1 CA 2183875A1 CA 002183875 A CA002183875 A CA 002183875A CA 2183875 A CA2183875 A CA 2183875A CA 2183875 A1 CA2183875 A1 CA 2183875A1
- Authority
- CA
- Canada
- Prior art keywords
- circuit
- electrotransport
- electrical
- delivery device
- disposed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
Abstract
An electrotransport agent delivery device (10) having a simplified structure and case of manufacture is provided. The device (10) utilizes an electrical circuit (40) disposed upon one of two opposing sides (43, 45) of a flexible.
non-conductive substrate (42). The electrical circuit (40) comprises a source of electrical energy (46), one or more electrically conductive circuit pathways (44) and a circuit output means (43). The circuit output means (43) are connected directly or indirectly, e.g., by means of an electrically conductive adhesive (34) to the remaining components of the device such as current distribution members, lead wires, or electrodes (60, 62). In this arrangement the circuit (40) is inverted from that of conventional electrotransport devices such that the surface (45) of the flexible substrate (42) having the electrical crrcuit (40) disposed thereon faces the body surface through which the drug or other agent is delivered by electrotransport. Economical, reel-to-reel methods of manufacturing a one-sided electrotransport circuit (40) are disclosed.
non-conductive substrate (42). The electrical circuit (40) comprises a source of electrical energy (46), one or more electrically conductive circuit pathways (44) and a circuit output means (43). The circuit output means (43) are connected directly or indirectly, e.g., by means of an electrically conductive adhesive (34) to the remaining components of the device such as current distribution members, lead wires, or electrodes (60, 62). In this arrangement the circuit (40) is inverted from that of conventional electrotransport devices such that the surface (45) of the flexible substrate (42) having the electrical crrcuit (40) disposed thereon faces the body surface through which the drug or other agent is delivered by electrotransport. Economical, reel-to-reel methods of manufacturing a one-sided electrotransport circuit (40) are disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/889,950 US5312326A (en) | 1992-06-02 | 1992-06-02 | Iontophoretic drug delivery apparatus |
PCT/US1994/002985 WO1995025562A1 (en) | 1992-06-02 | 1994-03-18 | Electrotransport drug delivery device |
US08/222,122 US5466217A (en) | 1992-06-02 | 1994-04-04 | Iontophoretic drug delivery apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2183875A1 true CA2183875A1 (en) | 1995-09-28 |
CA2183875C CA2183875C (en) | 2003-10-14 |
Family
ID=27377626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002183875A Expired - Fee Related CA2183875C (en) | 1992-06-02 | 1994-03-18 | Electrotransport drug delivery device |
Country Status (8)
Country | Link |
---|---|
US (1) | US5466217A (en) |
EP (1) | EP0751801B1 (en) |
JP (1) | JP3488466B2 (en) |
AT (1) | ATE160510T1 (en) |
CA (1) | CA2183875C (en) |
DE (1) | DE69407061T2 (en) |
ES (1) | ES2112552T3 (en) |
WO (1) | WO1995025562A1 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3565903B2 (en) * | 1994-06-25 | 2004-09-15 | 久光製薬株式会社 | Electrode structure for iontophoresis |
EP1762268A1 (en) | 1995-09-29 | 2007-03-14 | Vyteris, Inc. | Low-cost electrodes for an iontophoretic device |
US6385487B1 (en) | 1996-05-08 | 2002-05-07 | Biophoretic Therapeutic Systems, Llc | Methods for electrokinetic delivery of medicaments |
US5908401A (en) * | 1996-05-08 | 1999-06-01 | The Aps Organization, Llp | Method for iontophoretic delivery of antiviral agents |
US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
US5817151A (en) * | 1996-06-04 | 1998-10-06 | Survivalink Corporation | Circuit detectable packaged medical electrodes |
US5961483A (en) * | 1996-06-19 | 1999-10-05 | Sage; Burton H. | Iontophoretic delivery of cell adhesion inhibitors |
ATE373957T1 (en) | 1997-10-09 | 2007-10-15 | Univ Emory | METHOD AND DEVICE FOR TRANSDERMAL ADMINISTRATION OF LITHIUM |
USRE37796E1 (en) | 1997-12-16 | 2002-07-23 | Biophoretic Therapeutic Systems, Llc | Methods for iontophoretic delivery of antiviral agents |
JP4262410B2 (en) | 1998-01-28 | 2009-05-13 | アルザ・コーポレーション | Electrical transmission electrode assembly with low initial resistance |
US6115638A (en) * | 1998-05-04 | 2000-09-05 | Survivalink Corporation | Medical electrode with conductive release liner |
EP1115454B1 (en) * | 1998-08-31 | 2006-10-25 | Travanti Pharma Inc | Controlled dosage drug delivery system |
US6148231A (en) * | 1998-09-15 | 2000-11-14 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US6477410B1 (en) | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
US6553253B1 (en) | 1999-03-12 | 2003-04-22 | Biophoretic Therapeutic Systems, Llc | Method and system for electrokinetic delivery of a substance |
US6421561B1 (en) * | 1999-12-30 | 2002-07-16 | Birch Point Medical, Inc. | Rate adjustable drug delivery system |
US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
US6653014B2 (en) | 2001-05-30 | 2003-11-25 | Birch Point Medical, Inc. | Power sources for iontophoretic drug delivery systems |
US6916120B2 (en) * | 2002-01-30 | 2005-07-12 | Adc Telecommunications, Inc. | Fiber optic connector and method |
US6745071B1 (en) | 2003-02-21 | 2004-06-01 | Birch Point Medical, Inc. | Iontophoretic drug delivery system |
US7477938B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Cosumer Companies, Inc. | Device for delivery of active agents to barrier membranes |
US7507228B2 (en) | 2003-06-30 | 2009-03-24 | Johnson & Johnson Consumer Companies, Inc. | Device containing a light emitting diode for treatment of barrier membranes |
US7479133B2 (en) * | 2003-06-30 | 2009-01-20 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating acne and rosacea with galvanic generated electricity |
US7477940B2 (en) | 2003-06-30 | 2009-01-13 | J&J Consumer Companies, Inc. | Methods of administering an active agent to a human barrier membrane with galvanic generated electricity |
US20040265395A1 (en) * | 2003-06-30 | 2004-12-30 | Ying Sun | Device for delivery of reducing agents to barrier membranes |
US7477941B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of exfoliating the skin with electricity |
US7476222B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of reducing the appearance of pigmentation with galvanic generated electricity |
US7480530B2 (en) * | 2003-06-30 | 2009-01-20 | Johnson & Johnson Consumer Companies, Inc. | Device for treatment of barrier membranes |
US7477939B2 (en) | 2003-06-30 | 2009-01-13 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating a wound with galvanic generated electricity |
US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
US7486989B2 (en) | 2003-06-30 | 2009-02-03 | Johnson & Johnson Consumer Companies, Inc. | Device for delivery of oxidizing agents to barrier membranes |
US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
CA2586525C (en) | 2004-11-22 | 2013-01-15 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
NZ560516A (en) | 2005-02-01 | 2010-12-24 | Intelliject Inc | A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8386029B2 (en) * | 2005-03-31 | 2013-02-26 | Encore Medical Asset Corporation | Apparatus for electrotherapy drug delivery with added impurities |
US7856263B2 (en) * | 2005-04-22 | 2010-12-21 | Travanti Pharma Inc. | Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis |
CA2935569A1 (en) * | 2006-04-13 | 2007-10-25 | Teva Pharmaceuticals International Gmbh | Transdermal methods and systems for the delivery of anti-migraine compounds |
US7824383B2 (en) * | 2006-06-16 | 2010-11-02 | Family Health International | Vaginal drug delivery system and method |
US8137327B2 (en) * | 2006-06-16 | 2012-03-20 | Family Health International | Vaginal drug delivery system and method |
US7904146B2 (en) * | 2006-11-13 | 2011-03-08 | Travanti Pharma Inc. | Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions |
EP2125075A2 (en) | 2007-01-22 | 2009-12-02 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
EP2644228A1 (en) | 2007-06-27 | 2013-10-02 | The General Hospital Corporation | Method and apparatus for optical inhibition of photodynamic therapy |
US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
US8155737B2 (en) * | 2008-06-19 | 2012-04-10 | Nupathe, Inc. | Pharmacokinetics of iontophoretic sumatriptan administration |
US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
US8150525B2 (en) | 2008-08-27 | 2012-04-03 | Johnson & Johnson Consumer Companies, Inc. | Treatment of hyperhydrosis |
US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
CN102573489A (en) | 2009-08-10 | 2012-07-11 | 纽帕特公司 | Methods for iontophoretically treating nausea and migraine |
WO2011046927A1 (en) * | 2009-10-13 | 2011-04-21 | Nupathe,Inc. | Transdermal methods and systems for the delivery of rizatriptan |
CA2780537A1 (en) | 2009-11-13 | 2011-05-19 | Johnson & Johnson Consumer Companies, Inc. | Galvanic skin treatment device |
CN102762252B (en) | 2010-02-12 | 2015-04-29 | 泰尔茂株式会社 | Iontophoresis patch |
US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
WO2014106056A2 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
AU2016235054B2 (en) | 2015-03-24 | 2020-07-16 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
JP6830067B2 (en) | 2015-06-30 | 2021-02-17 | カレオ,インコーポレイテッド | Automatic syringe that administers medication in a prefilled syringe |
AU2017379094B2 (en) | 2016-12-23 | 2023-08-24 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
US10332623B2 (en) | 2017-01-17 | 2019-06-25 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
US11929160B2 (en) | 2018-07-16 | 2024-03-12 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
CA3145580A1 (en) | 2019-08-09 | 2021-02-18 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE399044A (en) * | 1933-09-09 | |||
US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
US3989816A (en) * | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4250878A (en) * | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
JPS56501274A (en) * | 1979-10-10 | 1981-09-10 | ||
US4424210A (en) * | 1980-04-04 | 1984-01-03 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
US4415563A (en) * | 1980-04-04 | 1983-11-15 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclononan-2-ones |
US4383529A (en) * | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
JPS5810066A (en) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | Plaster structure for ion tofuorese |
EP0092015A1 (en) * | 1982-04-16 | 1983-10-26 | Roland Brodard | Ionizing device |
US4622031A (en) * | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
US4883457A (en) * | 1983-08-18 | 1989-11-28 | Drug Delivery Systems Inc. | Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same |
US4708716A (en) * | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US4725263A (en) * | 1986-07-31 | 1988-02-16 | Medtronic, Inc. | Programmable constant current source transdermal drug delivery system |
US4865582A (en) * | 1987-06-05 | 1989-09-12 | Drug Delivery Systems Inc. | Disposable transdermal drug applicators |
US4942883A (en) * | 1987-09-29 | 1990-07-24 | Newman Martin H | Drug delivery device |
US4927408A (en) * | 1988-10-03 | 1990-05-22 | Alza Corporation | Electrotransport transdermal system |
EP0419473A1 (en) * | 1988-11-28 | 1991-04-03 | Innofinance Altalanos Innovacios Penzintetet | Iontophoresis apparatus |
US5023085A (en) * | 1989-11-29 | 1991-06-11 | Pfizer Inc. | Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals |
US5160316A (en) * | 1990-09-10 | 1992-11-03 | Henley Julian L | Iontophoretic drug delivery apparatus |
CA2123428A1 (en) * | 1991-11-13 | 1993-05-27 | John Corish | Drug delivery device |
US5167167A (en) * | 1991-11-18 | 1992-12-01 | United Technologies Corporation | Rotor trim balancing |
US5312326A (en) * | 1992-06-02 | 1994-05-17 | Alza Corporation | Iontophoretic drug delivery apparatus |
-
1994
- 1994-03-18 AT AT94923145T patent/ATE160510T1/en not_active IP Right Cessation
- 1994-03-18 DE DE69407061T patent/DE69407061T2/en not_active Expired - Lifetime
- 1994-03-18 ES ES94923145T patent/ES2112552T3/en not_active Expired - Lifetime
- 1994-03-18 EP EP94923145A patent/EP0751801B1/en not_active Expired - Lifetime
- 1994-03-18 JP JP52461195A patent/JP3488466B2/en not_active Expired - Fee Related
- 1994-03-18 WO PCT/US1994/002985 patent/WO1995025562A1/en active IP Right Grant
- 1994-03-18 CA CA002183875A patent/CA2183875C/en not_active Expired - Fee Related
- 1994-04-04 US US08/222,122 patent/US5466217A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE160510T1 (en) | 1997-12-15 |
ES2112552T3 (en) | 1998-04-01 |
CA2183875C (en) | 2003-10-14 |
US5466217A (en) | 1995-11-14 |
DE69407061T2 (en) | 1998-06-04 |
EP0751801A1 (en) | 1997-01-08 |
JP3488466B2 (en) | 2004-01-19 |
JPH09510387A (en) | 1997-10-21 |
EP0751801B1 (en) | 1997-11-26 |
DE69407061D1 (en) | 1998-01-08 |
WO1995025562A1 (en) | 1995-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2183875A1 (en) | Electrotransport drug delivery device | |
AU2003231143A1 (en) | Implantable medical lead for electrical stimulation and method of manufacturing the same | |
EP0294882A3 (en) | High voltage semiconductor with integrated low voltage circuitry | |
TW341722B (en) | Surface-mounted semiconductor package and its manufacturing method | |
TW328643B (en) | Semiconductor device and process for producing the same | |
AU4399193A (en) | Iontophoretic drug delivery apparatus | |
DE69026992D1 (en) | Process of mutual connection of electrode connections | |
ES474519A1 (en) | Lead frame and package for establishing electrical connections to electronic components. | |
WO1997016846A3 (en) | Chip module | |
JPS5997676A (en) | Magnetic treating device | |
GR3031594T3 (en) | Energy dissipation resistor for implantable defibrillator. | |
DE69907624D1 (en) | Electromechanical switching device with controlled impedance environment | |
JPS646837Y2 (en) | ||
JPS646836Y2 (en) | ||
JPS6454365A (en) | Prober | |
GB9121604D0 (en) | Pressure-contact type semiconductor device | |
JPS6414997A (en) | Shielding device of electronic apparatus | |
ES274595U (en) | Electronic device electrically connected to external contact elements. | |
JPS6448033A (en) | Packaging structure of liquid crystal panel | |
JPS6455295A (en) | Integrated circuit device | |
JPS62134982A (en) | Flat type led | |
JPS57139948A (en) | Semiconductor device | |
JPS6454364A (en) | Prober | |
JPS57187964A (en) | Hybrid integrated circuit | |
KR960015042B1 (en) | Camera |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |