CA2183875A1 - Electrotransport drug delivery device - Google Patents

Electrotransport drug delivery device

Info

Publication number
CA2183875A1
CA2183875A1 CA002183875A CA2183875A CA2183875A1 CA 2183875 A1 CA2183875 A1 CA 2183875A1 CA 002183875 A CA002183875 A CA 002183875A CA 2183875 A CA2183875 A CA 2183875A CA 2183875 A1 CA2183875 A1 CA 2183875A1
Authority
CA
Canada
Prior art keywords
circuit
electrotransport
electrical
delivery device
disposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002183875A
Other languages
French (fr)
Other versions
CA2183875C (en
Inventor
Robert M. Myers
Ronald P. Haak
Richard W. Plue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Robert M. Myers
Ronald P. Haak
Richard W. Plue
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/889,950 external-priority patent/US5312326A/en
Application filed by Robert M. Myers, Ronald P. Haak, Richard W. Plue, Alza Corporation filed Critical Robert M. Myers
Publication of CA2183875A1 publication Critical patent/CA2183875A1/en
Application granted granted Critical
Publication of CA2183875C publication Critical patent/CA2183875C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs

Abstract

An electrotransport agent delivery device (10) having a simplified structure and case of manufacture is provided. The device (10) utilizes an electrical circuit (40) disposed upon one of two opposing sides (43, 45) of a flexible.
non-conductive substrate (42). The electrical circuit (40) comprises a source of electrical energy (46), one or more electrically conductive circuit pathways (44) and a circuit output means (43). The circuit output means (43) are connected directly or indirectly, e.g., by means of an electrically conductive adhesive (34) to the remaining components of the device such as current distribution members, lead wires, or electrodes (60, 62). In this arrangement the circuit (40) is inverted from that of conventional electrotransport devices such that the surface (45) of the flexible substrate (42) having the electrical crrcuit (40) disposed thereon faces the body surface through which the drug or other agent is delivered by electrotransport. Economical, reel-to-reel methods of manufacturing a one-sided electrotransport circuit (40) are disclosed.
CA002183875A 1992-06-02 1994-03-18 Electrotransport drug delivery device Expired - Fee Related CA2183875C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/889,950 US5312326A (en) 1992-06-02 1992-06-02 Iontophoretic drug delivery apparatus
PCT/US1994/002985 WO1995025562A1 (en) 1992-06-02 1994-03-18 Electrotransport drug delivery device
US08/222,122 US5466217A (en) 1992-06-02 1994-04-04 Iontophoretic drug delivery apparatus

Publications (2)

Publication Number Publication Date
CA2183875A1 true CA2183875A1 (en) 1995-09-28
CA2183875C CA2183875C (en) 2003-10-14

Family

ID=27377626

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002183875A Expired - Fee Related CA2183875C (en) 1992-06-02 1994-03-18 Electrotransport drug delivery device

Country Status (8)

Country Link
US (1) US5466217A (en)
EP (1) EP0751801B1 (en)
JP (1) JP3488466B2 (en)
AT (1) ATE160510T1 (en)
CA (1) CA2183875C (en)
DE (1) DE69407061T2 (en)
ES (1) ES2112552T3 (en)
WO (1) WO1995025562A1 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3565903B2 (en) * 1994-06-25 2004-09-15 久光製薬株式会社 Electrode structure for iontophoresis
EP1762268A1 (en) 1995-09-29 2007-03-14 Vyteris, Inc. Low-cost electrodes for an iontophoretic device
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
US5676648A (en) * 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US5817151A (en) * 1996-06-04 1998-10-06 Survivalink Corporation Circuit detectable packaged medical electrodes
US5961483A (en) * 1996-06-19 1999-10-05 Sage; Burton H. Iontophoretic delivery of cell adhesion inhibitors
ATE373957T1 (en) 1997-10-09 2007-10-15 Univ Emory METHOD AND DEVICE FOR TRANSDERMAL ADMINISTRATION OF LITHIUM
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
JP4262410B2 (en) 1998-01-28 2009-05-13 アルザ・コーポレーション Electrical transmission electrode assembly with low initial resistance
US6115638A (en) * 1998-05-04 2000-09-05 Survivalink Corporation Medical electrode with conductive release liner
EP1115454B1 (en) * 1998-08-31 2006-10-25 Travanti Pharma Inc Controlled dosage drug delivery system
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6553253B1 (en) 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
US6421561B1 (en) * 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
US6653014B2 (en) 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
US6916120B2 (en) * 2002-01-30 2005-07-12 Adc Telecommunications, Inc. Fiber optic connector and method
US6745071B1 (en) 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system
US7477938B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7507228B2 (en) 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7477940B2 (en) 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US20040265395A1 (en) * 2003-06-30 2004-12-30 Ying Sun Device for delivery of reducing agents to barrier membranes
US7477941B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US7476222B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7477939B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7486989B2 (en) 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
CA2586525C (en) 2004-11-22 2013-01-15 Intelliject, Llc Devices, systems, and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
NZ560516A (en) 2005-02-01 2010-12-24 Intelliject Inc A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8386029B2 (en) * 2005-03-31 2013-02-26 Encore Medical Asset Corporation Apparatus for electrotherapy drug delivery with added impurities
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
CA2935569A1 (en) * 2006-04-13 2007-10-25 Teva Pharmaceuticals International Gmbh Transdermal methods and systems for the delivery of anti-migraine compounds
US7824383B2 (en) * 2006-06-16 2010-11-02 Family Health International Vaginal drug delivery system and method
US8137327B2 (en) * 2006-06-16 2012-03-20 Family Health International Vaginal drug delivery system and method
US7904146B2 (en) * 2006-11-13 2011-03-08 Travanti Pharma Inc. Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions
EP2125075A2 (en) 2007-01-22 2009-12-02 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2644228A1 (en) 2007-06-27 2013-10-02 The General Hospital Corporation Method and apparatus for optical inhibition of photodynamic therapy
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
US8155737B2 (en) * 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
CN102573489A (en) 2009-08-10 2012-07-11 纽帕特公司 Methods for iontophoretically treating nausea and migraine
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
CA2780537A1 (en) 2009-11-13 2011-05-19 Johnson & Johnson Consumer Companies, Inc. Galvanic skin treatment device
CN102762252B (en) 2010-02-12 2015-04-29 泰尔茂株式会社 Iontophoresis patch
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
WO2014106056A2 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
AU2016235054B2 (en) 2015-03-24 2020-07-16 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
JP6830067B2 (en) 2015-06-30 2021-02-17 カレオ,インコーポレイテッド Automatic syringe that administers medication in a prefilled syringe
AU2017379094B2 (en) 2016-12-23 2023-08-24 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US10332623B2 (en) 2017-01-17 2019-06-25 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
CA3145580A1 (en) 2019-08-09 2021-02-18 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE399044A (en) * 1933-09-09
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4405616A (en) * 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US3989816A (en) * 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
JPS56501274A (en) * 1979-10-10 1981-09-10
US4424210A (en) * 1980-04-04 1984-01-03 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4415563A (en) * 1980-04-04 1983-11-15 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclononan-2-ones
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
JPS5810066A (en) * 1981-07-10 1983-01-20 株式会社アドバンス Plaster structure for ion tofuorese
EP0092015A1 (en) * 1982-04-16 1983-10-26 Roland Brodard Ionizing device
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4883457A (en) * 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US4708716A (en) * 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
EP0419473A1 (en) * 1988-11-28 1991-04-03 Innofinance Altalanos Innovacios Penzintetet Iontophoresis apparatus
US5023085A (en) * 1989-11-29 1991-06-11 Pfizer Inc. Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
US5160316A (en) * 1990-09-10 1992-11-03 Henley Julian L Iontophoretic drug delivery apparatus
CA2123428A1 (en) * 1991-11-13 1993-05-27 John Corish Drug delivery device
US5167167A (en) * 1991-11-18 1992-12-01 United Technologies Corporation Rotor trim balancing
US5312326A (en) * 1992-06-02 1994-05-17 Alza Corporation Iontophoretic drug delivery apparatus

Also Published As

Publication number Publication date
ATE160510T1 (en) 1997-12-15
ES2112552T3 (en) 1998-04-01
CA2183875C (en) 2003-10-14
US5466217A (en) 1995-11-14
DE69407061T2 (en) 1998-06-04
EP0751801A1 (en) 1997-01-08
JP3488466B2 (en) 2004-01-19
JPH09510387A (en) 1997-10-21
EP0751801B1 (en) 1997-11-26
DE69407061D1 (en) 1998-01-08
WO1995025562A1 (en) 1995-09-28

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