CA2185196C - Method and apparatus for skin rejuvenation and wrinkle smoothing - Google Patents
Method and apparatus for skin rejuvenation and wrinkle smoothing Download PDFInfo
- Publication number
- CA2185196C CA2185196C CA002185196A CA2185196A CA2185196C CA 2185196 C CA2185196 C CA 2185196C CA 002185196 A CA002185196 A CA 002185196A CA 2185196 A CA2185196 A CA 2185196A CA 2185196 C CA2185196 C CA 2185196C
- Authority
- CA
- Canada
- Prior art keywords
- skin
- light source
- light
- laser
- pulses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003716 rejuvenation Effects 0.000 title claims description 17
- 230000037303 wrinkles Effects 0.000 title claims description 17
- 238000000034 method Methods 0.000 title abstract description 24
- 238000009499 grossing Methods 0.000 title description 6
- 102000008186 Collagen Human genes 0.000 claims abstract description 23
- 108010035532 Collagen Proteins 0.000 claims abstract description 23
- 229920001436 collagen Polymers 0.000 claims abstract description 23
- 238000001816 cooling Methods 0.000 claims abstract description 23
- 230000005855 radiation Effects 0.000 claims abstract description 19
- 238000001228 spectrum Methods 0.000 claims abstract description 12
- 239000000126 substance Substances 0.000 claims abstract description 12
- 239000010979 ruby Substances 0.000 claims abstract description 6
- 229910001750 ruby Inorganic materials 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 238000010438 heat treatment Methods 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 89
- 210000002615 epidermis Anatomy 0.000 abstract description 22
- 239000002826 coolant Substances 0.000 abstract description 3
- 230000001427 coherent effect Effects 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 9
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 230000001934 delay Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000013021 overheating Methods 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000012260 Accidental injury Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000003079 ectropion Diseases 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000037339 smooth wrinkles Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00137—Details of operation mode
- A61B2017/00154—Details of operation mode pulsed
- A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
Abstract
A method and apparatus for treating skin includes applying pulsed light to the skin to heat and shrinking collagen within the skin, thereby reviving the elasticity of the collagen and of the skin. The epidermis and outer layers of the skin may be protected by cooling with a transparent substance, such as ice or gel, to the skin. The temperature distribution within the skin is controlled by controlling the delay between the time the coolant is applied, and the time the light is applied, by controlling the pulse duration and applying multiple pulses, and by filtering the light and controlling the radiation spectrum, preferably, the spectrum includes light having a wavelength in the range of 600-1200nm. The pulsed light may be incoherent, such as that produced by a flashlamp, or coherent, such as that produced by a Nd(Yag) laser or a ruby laser, and may be directed to the skin using a flexible or rigid light guide. Also, a method and apparatus for cutaneous resurfacing including directing Er:YAG laser light to the skin. The light may be pulsed, preferably with a delay of about 0.5-l0msec between pulses. In one embodiment the pulses have energy fluences of preferably about 100J/cm2.
Description
=
METHOD AND APPARATUS FOR SKIN
REJUVENATION AND WRINKLE SMOOTHING
FIELD OF TH . INVENTION
The present invention relates generally to the art 5, of skin treatment using electromagnetic radiation. More particularly, the invention relates to an efficient method and apparatus for skin rejuvenation by ablation of the outer layer of the skin and wrinkle smoothing (or shrinking) by heating of collagen without damage to the epidermis.
$ACKGROUND OF THE INVENTION
There is a strong desire today to obtain and/or maintain a youthful appearance. One manner of doing so is to remove (or reduce) wrinkles. Additionally it is desirable to rejuvenate the skin by removing an outer layer of skin. There are known techniques for removing wrinkles by peeling the skin. Also, there are known methods for rejuvenating the skin. Unfortunately, all known techniques suffer from lack of efficacy and risk to the patient.
=
METHOD AND APPARATUS FOR SKIN
REJUVENATION AND WRINKLE SMOOTHING
FIELD OF TH . INVENTION
The present invention relates generally to the art 5, of skin treatment using electromagnetic radiation. More particularly, the invention relates to an efficient method and apparatus for skin rejuvenation by ablation of the outer layer of the skin and wrinkle smoothing (or shrinking) by heating of collagen without damage to the epidermis.
$ACKGROUND OF THE INVENTION
There is a strong desire today to obtain and/or maintain a youthful appearance. One manner of doing so is to remove (or reduce) wrinkles. Additionally it is desirable to rejuvenate the skin by removing an outer layer of skin. There are known techniques for removing wrinkles by peeling the skin. Also, there are known methods for rejuvenating the skin. Unfortunately, all known techniques suffer from lack of efficacy and risk to the patient.
=
-2-One known method of skin rejuvenation includes injection of collagen underneath the skin. This has been performed using a bovine collagen injection. For example, microfine collagen has been injected into periocular lines.
Some of the problems with collagen injection include, allergy to collagen and lack of longevity. Also, often there is only partial eradication of the wrinkles.
Peeling most or all of the outer layer of the skin is another known method of rejuvenating the skin. Peeling can be achieved chemically, mechanically or photothermally.
Chemical peeling is often carried out using trichloroacetic acid and phenol. _P.n inability to control the depth of the peeling, possible pigmentary change and risk of scarring are among the problems associated with chemical peeling.
The mechanical method is called transcutaneous blepharoplasty and involves shaving off the outer layer of skin. Skin resectionduring lower lid blepharoplasty frequently results in undesirable side effects, especially ectropion and scleral=show. Moreover, transcutaneous blepharoplasty rarely eradicates all of the wrinkle lines.
Pulsed carbon dioxide laser treatment is a known photothermal method of removing of periocular wrinkles.
However, laser light is heavily absorbed in water and has a very short range in the epidermis. Thus, a high fluence with short pulse durations will evaporate the outer layer of the skin and peels most or all of the epidermis.
The use of CO2 laser light for skin rejuvenation also has undesirable side effects. For example, C02 lasers have small spot size (3mm or less), and thus their use causes valleys and ridges, particularly when resurfacing large areas~ Also, it is difficult to control heat
Some of the problems with collagen injection include, allergy to collagen and lack of longevity. Also, often there is only partial eradication of the wrinkles.
Peeling most or all of the outer layer of the skin is another known method of rejuvenating the skin. Peeling can be achieved chemically, mechanically or photothermally.
Chemical peeling is often carried out using trichloroacetic acid and phenol. _P.n inability to control the depth of the peeling, possible pigmentary change and risk of scarring are among the problems associated with chemical peeling.
The mechanical method is called transcutaneous blepharoplasty and involves shaving off the outer layer of skin. Skin resectionduring lower lid blepharoplasty frequently results in undesirable side effects, especially ectropion and scleral=show. Moreover, transcutaneous blepharoplasty rarely eradicates all of the wrinkle lines.
Pulsed carbon dioxide laser treatment is a known photothermal method of removing of periocular wrinkles.
However, laser light is heavily absorbed in water and has a very short range in the epidermis. Thus, a high fluence with short pulse durations will evaporate the outer layer of the skin and peels most or all of the epidermis.
The use of CO2 laser light for skin rejuvenation also has undesirable side effects. For example, C02 lasers have small spot size (3mm or less), and thus their use causes valleys and ridges, particularly when resurfacing large areas~ Also, it is difficult to control heat
-3-diffusion, and thus the resultant necrosis is difficult to predict and control. Additionally, scar tissue absorbs COZ
laser light differently than normal skin and thus may adversely impact such a treatment.
Thus, it is apparent there is a need for a new method and device with which it is possible to produce efficient wrinkle removal and skin rejuvenation. This apparatus would preferably be able to control the treatment parameters according to characteristics of the tissue, and be easily tunable. The new method and device would preferably provide efficient wrinkle smoothing and skin rejuvenation with minimal side effects.
S TMMARY OF T$$ P RS NT TTTVFNTTCIN
In accordance with one aspect of the invention a method and apparatus for treating skin includes applying pulsed light to the skin to heat and shrinking collagen within the skin, thereby reviving the elasticity of the collagen and of the skin. In one embodiment the method also includes protecting the epidermis and outer layers of the skin by cooling the epidermis and outer layers of the skin.
The cooling may be accomplished by applying a cooled transparent substance; such as ice or gel, to the skin.
In one alternative embodiment the skin is cooled by applying the transparent substance to the skin and then cooling it.
In another alternative embodiment the temperature distribution within the skin is controlled by controlling the delay between the.time the coolant is applied, and the time the light is applied. A microprocessor may be used for determining the delay time in response to a selected skin
laser light differently than normal skin and thus may adversely impact such a treatment.
Thus, it is apparent there is a need for a new method and device with which it is possible to produce efficient wrinkle removal and skin rejuvenation. This apparatus would preferably be able to control the treatment parameters according to characteristics of the tissue, and be easily tunable. The new method and device would preferably provide efficient wrinkle smoothing and skin rejuvenation with minimal side effects.
S TMMARY OF T$$ P RS NT TTTVFNTTCIN
In accordance with one aspect of the invention a method and apparatus for treating skin includes applying pulsed light to the skin to heat and shrinking collagen within the skin, thereby reviving the elasticity of the collagen and of the skin. In one embodiment the method also includes protecting the epidermis and outer layers of the skin by cooling the epidermis and outer layers of the skin.
The cooling may be accomplished by applying a cooled transparent substance; such as ice or gel, to the skin.
In one alternative embodiment the skin is cooled by applying the transparent substance to the skin and then cooling it.
In another alternative embodiment the temperature distribution within the skin is controlled by controlling the delay between the.time the coolant is applied, and the time the light is applied. A microprocessor may be used for determining the delay time in response to a selected skin
-4-temperature profile. Additionally, the temperature distribution may be controlled by controlling the pulse duration and applying multiple pulses. In another embodiment the temperature distribution within the skin is controlled by filtering the light and controlling the radiation spectrum. Preferably, the spectrum includes light having a wavelength in the range of 600-1200nm.
In another embodiment the pulsed light may be incoherent, such as that produced by a flashlamp, or coherent, such as that produced by an Nd(Yag) laser or a ruby laser. -- -In another embodiment the light is directed to the skin using a flexible.or rigid light guide.
In accordance with a second aspect of the invention a method and apparatus for generating a temperature distribution inside a region of skin having a maximum temperature at a selected depth includes cooling the epidermis and outer layers of the skin and applying pulsed light to the skin.
In one embodiment the cooling is accomplished by applying a cooled transparent substance, such as gel or ice, to the skin. Alternatively, the cooling may be accomplished by applying the transparent substance, and then cooling it.
The temperature distribution is further controlled in one embodiment by controlling the delay between the cooling and the light application. In another embodiment the distribution is controlled by controlling the pulse duration and/or applying multiple pulses.
In accordance with a third aspect of the invention a method and apparatus for cutaneous resurfacing includes directing Er:YAG laser light to the skin. The light may be
In another embodiment the pulsed light may be incoherent, such as that produced by a flashlamp, or coherent, such as that produced by an Nd(Yag) laser or a ruby laser. -- -In another embodiment the light is directed to the skin using a flexible.or rigid light guide.
In accordance with a second aspect of the invention a method and apparatus for generating a temperature distribution inside a region of skin having a maximum temperature at a selected depth includes cooling the epidermis and outer layers of the skin and applying pulsed light to the skin.
In one embodiment the cooling is accomplished by applying a cooled transparent substance, such as gel or ice, to the skin. Alternatively, the cooling may be accomplished by applying the transparent substance, and then cooling it.
The temperature distribution is further controlled in one embodiment by controlling the delay between the cooling and the light application. In another embodiment the distribution is controlled by controlling the pulse duration and/or applying multiple pulses.
In accordance with a third aspect of the invention a method and apparatus for cutaneous resurfacing includes directing Er:YAG laser light to the skin. The light may be
- 5 -pulsed, preferably with a delay of about 0.5-10 msec between pulses. In one embodiment the pulses have energy fluences of preferably about 100J/cm2.
In accordance with a fourth aspect of the invention an apparatus for the cutaneous resurfacing of a region of skin, including skin resurfacing or wrinkle smoothing, includes an incoherent light source such as a flashlamp and an Er:YAG laser. The laser can be operated in a multiple pulse mode. A delivery system delivers the incoherent light and laser light to the region to be treated, and the region may be cooled.
Other principal features and advantages of the invention will become apparent to those skilled in the art upon review of the following drawings, the detailed description and the appended claims.
In accordance with a fifth aspect of the present invention, there is provided an apparatus for treating a region of skin comprising;
a pulsed light source for heating and shrinking the collagen in the region of skin to a degree sufficient to reduce wrinkles in the region of skin;
a housing in which the pulsed light source is disposed, wherein the housing includes an aperture disposed with respect to the pulsed light source to direct light emitted from the light source to the region of skin; and a timer, connected to the pulsed light source, for indicating when a delay time has passed after an application of a cooling substance to the skin region.
5a In accordance with a sixth aspect of the present invention, there is provided an apparatus for skin rejuvenation by removing at least an outer layer of skin in a region of skin comprising:
an Er:YAG laser light source disposed in a housing capable of directing light to the region of skin for a duration and with an intensity sufficient to remove the outer layer;
a pulse forming circuit coupled to the Er:YAG laser light source including a pulse delay circuit for providing a delay between sequential pulses of Er:YAG light for a period of time not less than the thermal relaxation time of the skin.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 shows a temperature distribution achieved inside the skin after a cold fluid was applied to the skin, for a plurality of different time delays after the application of the cold gel;
Figure 2 shows a temperature distribution achieved by precooling the skin and applying the light source;
Figure 3 is a schematic illustration of the flashlamp light source according to one preferred embodiment of the present invention; and Figure 4 shows a normalized output filtered radiation spectrum of a flashlamp light source.
Before explaining at least one embodiment of the invention in detail it is to be understood that the invention is not limited in its application to the details
In accordance with a fourth aspect of the invention an apparatus for the cutaneous resurfacing of a region of skin, including skin resurfacing or wrinkle smoothing, includes an incoherent light source such as a flashlamp and an Er:YAG laser. The laser can be operated in a multiple pulse mode. A delivery system delivers the incoherent light and laser light to the region to be treated, and the region may be cooled.
Other principal features and advantages of the invention will become apparent to those skilled in the art upon review of the following drawings, the detailed description and the appended claims.
In accordance with a fifth aspect of the present invention, there is provided an apparatus for treating a region of skin comprising;
a pulsed light source for heating and shrinking the collagen in the region of skin to a degree sufficient to reduce wrinkles in the region of skin;
a housing in which the pulsed light source is disposed, wherein the housing includes an aperture disposed with respect to the pulsed light source to direct light emitted from the light source to the region of skin; and a timer, connected to the pulsed light source, for indicating when a delay time has passed after an application of a cooling substance to the skin region.
5a In accordance with a sixth aspect of the present invention, there is provided an apparatus for skin rejuvenation by removing at least an outer layer of skin in a region of skin comprising:
an Er:YAG laser light source disposed in a housing capable of directing light to the region of skin for a duration and with an intensity sufficient to remove the outer layer;
a pulse forming circuit coupled to the Er:YAG laser light source including a pulse delay circuit for providing a delay between sequential pulses of Er:YAG light for a period of time not less than the thermal relaxation time of the skin.
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 shows a temperature distribution achieved inside the skin after a cold fluid was applied to the skin, for a plurality of different time delays after the application of the cold gel;
Figure 2 shows a temperature distribution achieved by precooling the skin and applying the light source;
Figure 3 is a schematic illustration of the flashlamp light source according to one preferred embodiment of the present invention; and Figure 4 shows a normalized output filtered radiation spectrum of a flashlamp light source.
Before explaining at least one embodiment of the invention in detail it is to be understood that the invention is not limited in its application to the details
-6-of construction-and the arrangement of the components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments or being practiced or catried out in various ways. Also, it is to be understood thatthe phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting.
DETAILED D.S-Rr Pr ON OF T , PREFERRED . ODrMENTS
The invention relates to a new method and apparatus of removing wrinkle and rejuvenating skin.
Generally, in accordance with this invention, wrinkles are smoothed or reduced by collagen molecules shrinking and increasing the elasticity of the skin and collagen, using a short heating impulse (thermal shock). Tissue is heated at a depth of up to a few millimeters by light radiation, while the skin is externally cooled at the surface to avoid overheating the epidermis. The epidermis may be cooled in a variety of ways, including applying a precooled (i.e., a temperature less than the ambient temperature) transparent substance such as ice or cold gel to the skin. The cold substance should cool the skin before and during treatment.
The light (electromagnetic radiation) is applied to the skin in pulses shortly after the application of the cooling material. Alternatively, the fluid or gel could be applied to the skin or skin surface, and then cooled (using thermoelectric cooler, e.g.) shortly before the application of the puised light to the skin.
The light source will preferably provide a spectrum such that the optical depth of penetration into the tissue is of the order of lmm or more. Also, the light 2?85196 -~-source will preferably be able to provide pulses having fluences of the order of 100J/cm2 and peak power of the order of 1000W/cm2. A spot size of the order of 10mm is preferable, to reduce, scattering losses.
Laser light sources that should be appropriate include a Nd(Yag) laser, a ruby laser, an alexandrite laser, diode lasers and others will be suitable. Incoherent light sources such as a xenon flashlamp should also be appropriate.
A method for cutaneous resurfacing (skin rejuvenation) in accordancewith the present invention includes use of an Er,:YAG laser light, which has a most efficient wavelength of 2.94pm. Because the absorption depth of an Er:YAG laser in skin is very small (less than 20 microns), it may be difficult to ablate to a depth of the order of 100 microns or more (typical of the epidermis) with it. However, a deeper depth of peeling can be achieved by extending the pulse length of the laser. While this is hard to achieve using an Er:YAG laser due to the inherent short level lifetime, by providing a few pulses with a variable delay between the pulses this limitation may be overcome.
Evaporated tissue layer thickness may be controlled by the number of pulses and variation of pulse parameters and delay between pulses. -The invention also relates to an apparatus using a flashlamp light source, or any other source with appropriate parameters, for smoothing wrinkles, without damaging the epidermis. Also, an Er:YAG laser is used for efficient skin rejuvenation by removal of the epidermis.
Generally, the device includes a flashlamp that can provide a pulsed light in the range of 600-1200nm for heating of collagen, a filter system that can cut off the radiation spectrum below approximately 600nm, a light guide that can provide an appropriate spot size and can provide fluences of the order:of 100 J/cmZ, andan Er:YAG laser with pulse energy of the order of1J, which can be operated in multiple pulse mode with delays between pulses of less than 50msec for skin rejuvenation (by skin ablative peeling).
In one alternative a light source such as a Nd(Yag) laser or rubylaser with appropriate parameters could replace the flashlamp.
This apparatus is very useful for wrinkle removal and skin rejuvenation. A flashlamp light source, particularly when used with external cooling of skin surface, will generate a temperature distribution inside the skin which has a maximum at depth dependent on the light and cooling. Consequently, it is possible to heat collagen molecules without damaging the epidermis. The temperature distribution in the skin is responsive to the delay time between the cooling and application of light, selection of pulse parameters and the radiation spectrum. Accordingly, appropriate control of these parameters allows control of the temperature distribution. An Er:YAG laser operated in multiple pulse mode is very efficient for cutaneous resurfacing procedures and also enables control of depth of evaporation. Thus, the apparatus is safe with little risk of accidental injury to the operator and patient.
As stated above, wrinkles may be smoothed by shrinking collagen molecules using pulsed heating. The present invention method is realized by heating of tissue to depths of up to a few millimeters by light radiation in association with external cooling of skin outer surface to avoid overheating of epidermis. The epidermis may be cooled using many methods. One preferred method is the application of a previously cooled transparent matter like ice or cold gel on the skin whichcools the skin before and during treatment. A temperature distribution inside the skin similar to one shown in Figure 1 is created a short time (of the order of 1 second) after the application of the cooled material.
As may be seen, the distribution is such that the epidermis and the outer layer of the skin are colder than the more deeper part of the skin. However, the applied light heats up the superficial parts of the skin more than the inner parts, because of the attenuation of light energy fluence by depth, and-due to higher absorption of light by the epidermis.
After heating a temperature distribution such as that shown in Figure 2 results. As may be seen, the deeper -parts of the tissue are heated up to a temperature sufficient to cause collagen shrinking, but without damaging the outer parts of the skin (epidermis).
The temperature distribution generated prior to the application of light (Figure 1) is a function of the initial temperature of the cooling material and the delay time between the application of the caoling material and the application of light. By varying this time the depth of penetration of the "cool front" can bevaried. When collagen that is deeper needs to be treated without influencing the superficial skin, a longer delay time between the application of the coolant and the light can be used. When the superficial collagen needs to be treated, a shorter delay time can be used.
~
In a typical treatment the doctor applies the cold gel to the skin before treatment and then applies the light source. In accordance with one embodiment of the invention, the treatment device:indicates to the doctor when the light source needs to be applied after application of the cooling material, to achieve a desired temperature distribution. A
microprocessor that controls the light generating device may also generate a timing signal for the doctor to accomplish this aspect of the invention.
The applicants have determined that a light source having the-following parameters is suitable for implementing the invention.
Light radiation should penetrate into a tissue at a millimeter depth. Examples of light sources which meet the parameter include flashlamp, diode laser, Nd(Yag) laser and ruby laser.
Optical power should be on the order of 100-1000 W/ cm2 .
Fluence should be on the order of 30-150 J/cm2.
Spot size should be on the order of a few millimeters to some centimeters, preferably variable over a range. -A detailed description of one preferred embodiment will be described with reference to Figure 3. As shown in Figure 3, a treatment device 300 includes a flashlamp 301 which can be operated.in pulse mode, a reflector 302 which forms a light beam and conducts it to a light guide 305 through a filter system 303 and 304. Reflector 302 is located in a treatment head (or housing) 306.
Filter system 303 and 304 may include one or more filters which cut off the radiation spectrum at approximately 550(or 600)-800nm. Filter 303 provides reflection of the part of unused incident radiation and avoids overheating of absorbing filter 304. Absorbing filter cuts off radiation at approximately 550-800nm.
Flexible light guide 305 can be interchanged with a rigid light guide made out of quartz or other types of high optical quality glass. Treatment head 305 is useful for treating large areas.
According to one embodiment, the light energy is applied to the skin using a train of pulses. One advantage of applying a train of pulses is that.the epidermis cools relative to the layer of collagen that is heated in the treatment. Preferably, the apparatus produces a train of pulses with variable delays between pulses in the range of 10's to 100's of milliseconds.
The total number of pulses per pulse train can also be varied. More specifically, for a patient with higher skin absorption due to heavier skin pigmentation a larger number of pulses per train is preferably used.
Similarly, the pulse duration of each pulse in the train can also be varied in order to enable cooling of the epidermis without cooling the collagen. In any event, the total dose to the treated area is the product of the number of pulses and the fluence per pulse. The pulse duration, and train length are controlled in one embodiment by a microprocessor 309. As shown on Figure 3, microprocessor 309 provides control signals to pulse forming network 310.
Pulse forming network 310 provides pulse to flashlamp 301.
The radiation spectrum can be controlled by filter system 303 and 304. Additionally (or alternatively), the spectrum of radiation can be controlled by varying the current density through the flashlamp. If deeper heating is required a longer wavelength radiation is used. Pulse duration may be varied in the range of a few milliseconds to a few ten's of milliseconds.
Other embodiments of the present invention include the use of lasers (those having proper penetration), which can also be very effective to smooth wrinkles. For example, a flashlamp pumped Nd(Yag) laser operating at 1.061,un can provide deep penetration and thus be effective. The laser may be operated in the pulsed train mode, preferably by pulsing the flashlamps that are used to pump the laser.
Similarly, a ruby laser may be used. However, the pulse duration cannot be made too long due to the limited value of the lifetime of the lasing level of these lasers. In the laser embodiment, there is no need for filters since the light is monochromatic. Also this embodiment does not require the use of a figid light guide since flexible light guides are readily available for laser applications and a low divergence laser beam can be easily focused into a small diameter optical fiber. The use of multiple pulses may be particularly useful to- overcome the limited lasing level in the laser embodiment of the invention.
The cutaneous resurfacing method in accordance with the present invention includes an Er:YAG laser light, whose radiation has an absorption depth of much less than that of CO2 laser radiation, of the order of 50 micron is used. Despite the relatively low absorption depth, an appropriate peeling depth is reached by providing multiple pulses. The thickness of the layer of evaporated tissue may be controlled by the number of pulses, the delay between pulses and varying pulse parameters.
Er:YAG lasers produce radiation of 2.94pm, with an energy per pulse of up to 1J. Absorption depth of the radiation is typically about 10}un. Thus, to evaporate an epidermis, a train of pulses should be used. Typical delay between the laser pulses should be in the range of 0.5-lOmsec. The time should preferably be shorter than, or on the order of, the epidermis thermal relaxation time.
Thus, it should be apparent that there has been provided in accordance with the present invention a treatment device that:includes a flashlamp or a near -infrared pulsed laser.in another embodiment, an Er:YAG laser and a coupler that fully satisfy the objectives and advantages set forth above. Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art.
Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.
DETAILED D.S-Rr Pr ON OF T , PREFERRED . ODrMENTS
The invention relates to a new method and apparatus of removing wrinkle and rejuvenating skin.
Generally, in accordance with this invention, wrinkles are smoothed or reduced by collagen molecules shrinking and increasing the elasticity of the skin and collagen, using a short heating impulse (thermal shock). Tissue is heated at a depth of up to a few millimeters by light radiation, while the skin is externally cooled at the surface to avoid overheating the epidermis. The epidermis may be cooled in a variety of ways, including applying a precooled (i.e., a temperature less than the ambient temperature) transparent substance such as ice or cold gel to the skin. The cold substance should cool the skin before and during treatment.
The light (electromagnetic radiation) is applied to the skin in pulses shortly after the application of the cooling material. Alternatively, the fluid or gel could be applied to the skin or skin surface, and then cooled (using thermoelectric cooler, e.g.) shortly before the application of the puised light to the skin.
The light source will preferably provide a spectrum such that the optical depth of penetration into the tissue is of the order of lmm or more. Also, the light 2?85196 -~-source will preferably be able to provide pulses having fluences of the order of 100J/cm2 and peak power of the order of 1000W/cm2. A spot size of the order of 10mm is preferable, to reduce, scattering losses.
Laser light sources that should be appropriate include a Nd(Yag) laser, a ruby laser, an alexandrite laser, diode lasers and others will be suitable. Incoherent light sources such as a xenon flashlamp should also be appropriate.
A method for cutaneous resurfacing (skin rejuvenation) in accordancewith the present invention includes use of an Er,:YAG laser light, which has a most efficient wavelength of 2.94pm. Because the absorption depth of an Er:YAG laser in skin is very small (less than 20 microns), it may be difficult to ablate to a depth of the order of 100 microns or more (typical of the epidermis) with it. However, a deeper depth of peeling can be achieved by extending the pulse length of the laser. While this is hard to achieve using an Er:YAG laser due to the inherent short level lifetime, by providing a few pulses with a variable delay between the pulses this limitation may be overcome.
Evaporated tissue layer thickness may be controlled by the number of pulses and variation of pulse parameters and delay between pulses. -The invention also relates to an apparatus using a flashlamp light source, or any other source with appropriate parameters, for smoothing wrinkles, without damaging the epidermis. Also, an Er:YAG laser is used for efficient skin rejuvenation by removal of the epidermis.
Generally, the device includes a flashlamp that can provide a pulsed light in the range of 600-1200nm for heating of collagen, a filter system that can cut off the radiation spectrum below approximately 600nm, a light guide that can provide an appropriate spot size and can provide fluences of the order:of 100 J/cmZ, andan Er:YAG laser with pulse energy of the order of1J, which can be operated in multiple pulse mode with delays between pulses of less than 50msec for skin rejuvenation (by skin ablative peeling).
In one alternative a light source such as a Nd(Yag) laser or rubylaser with appropriate parameters could replace the flashlamp.
This apparatus is very useful for wrinkle removal and skin rejuvenation. A flashlamp light source, particularly when used with external cooling of skin surface, will generate a temperature distribution inside the skin which has a maximum at depth dependent on the light and cooling. Consequently, it is possible to heat collagen molecules without damaging the epidermis. The temperature distribution in the skin is responsive to the delay time between the cooling and application of light, selection of pulse parameters and the radiation spectrum. Accordingly, appropriate control of these parameters allows control of the temperature distribution. An Er:YAG laser operated in multiple pulse mode is very efficient for cutaneous resurfacing procedures and also enables control of depth of evaporation. Thus, the apparatus is safe with little risk of accidental injury to the operator and patient.
As stated above, wrinkles may be smoothed by shrinking collagen molecules using pulsed heating. The present invention method is realized by heating of tissue to depths of up to a few millimeters by light radiation in association with external cooling of skin outer surface to avoid overheating of epidermis. The epidermis may be cooled using many methods. One preferred method is the application of a previously cooled transparent matter like ice or cold gel on the skin whichcools the skin before and during treatment. A temperature distribution inside the skin similar to one shown in Figure 1 is created a short time (of the order of 1 second) after the application of the cooled material.
As may be seen, the distribution is such that the epidermis and the outer layer of the skin are colder than the more deeper part of the skin. However, the applied light heats up the superficial parts of the skin more than the inner parts, because of the attenuation of light energy fluence by depth, and-due to higher absorption of light by the epidermis.
After heating a temperature distribution such as that shown in Figure 2 results. As may be seen, the deeper -parts of the tissue are heated up to a temperature sufficient to cause collagen shrinking, but without damaging the outer parts of the skin (epidermis).
The temperature distribution generated prior to the application of light (Figure 1) is a function of the initial temperature of the cooling material and the delay time between the application of the caoling material and the application of light. By varying this time the depth of penetration of the "cool front" can bevaried. When collagen that is deeper needs to be treated without influencing the superficial skin, a longer delay time between the application of the coolant and the light can be used. When the superficial collagen needs to be treated, a shorter delay time can be used.
~
In a typical treatment the doctor applies the cold gel to the skin before treatment and then applies the light source. In accordance with one embodiment of the invention, the treatment device:indicates to the doctor when the light source needs to be applied after application of the cooling material, to achieve a desired temperature distribution. A
microprocessor that controls the light generating device may also generate a timing signal for the doctor to accomplish this aspect of the invention.
The applicants have determined that a light source having the-following parameters is suitable for implementing the invention.
Light radiation should penetrate into a tissue at a millimeter depth. Examples of light sources which meet the parameter include flashlamp, diode laser, Nd(Yag) laser and ruby laser.
Optical power should be on the order of 100-1000 W/ cm2 .
Fluence should be on the order of 30-150 J/cm2.
Spot size should be on the order of a few millimeters to some centimeters, preferably variable over a range. -A detailed description of one preferred embodiment will be described with reference to Figure 3. As shown in Figure 3, a treatment device 300 includes a flashlamp 301 which can be operated.in pulse mode, a reflector 302 which forms a light beam and conducts it to a light guide 305 through a filter system 303 and 304. Reflector 302 is located in a treatment head (or housing) 306.
Filter system 303 and 304 may include one or more filters which cut off the radiation spectrum at approximately 550(or 600)-800nm. Filter 303 provides reflection of the part of unused incident radiation and avoids overheating of absorbing filter 304. Absorbing filter cuts off radiation at approximately 550-800nm.
Flexible light guide 305 can be interchanged with a rigid light guide made out of quartz or other types of high optical quality glass. Treatment head 305 is useful for treating large areas.
According to one embodiment, the light energy is applied to the skin using a train of pulses. One advantage of applying a train of pulses is that.the epidermis cools relative to the layer of collagen that is heated in the treatment. Preferably, the apparatus produces a train of pulses with variable delays between pulses in the range of 10's to 100's of milliseconds.
The total number of pulses per pulse train can also be varied. More specifically, for a patient with higher skin absorption due to heavier skin pigmentation a larger number of pulses per train is preferably used.
Similarly, the pulse duration of each pulse in the train can also be varied in order to enable cooling of the epidermis without cooling the collagen. In any event, the total dose to the treated area is the product of the number of pulses and the fluence per pulse. The pulse duration, and train length are controlled in one embodiment by a microprocessor 309. As shown on Figure 3, microprocessor 309 provides control signals to pulse forming network 310.
Pulse forming network 310 provides pulse to flashlamp 301.
The radiation spectrum can be controlled by filter system 303 and 304. Additionally (or alternatively), the spectrum of radiation can be controlled by varying the current density through the flashlamp. If deeper heating is required a longer wavelength radiation is used. Pulse duration may be varied in the range of a few milliseconds to a few ten's of milliseconds.
Other embodiments of the present invention include the use of lasers (those having proper penetration), which can also be very effective to smooth wrinkles. For example, a flashlamp pumped Nd(Yag) laser operating at 1.061,un can provide deep penetration and thus be effective. The laser may be operated in the pulsed train mode, preferably by pulsing the flashlamps that are used to pump the laser.
Similarly, a ruby laser may be used. However, the pulse duration cannot be made too long due to the limited value of the lifetime of the lasing level of these lasers. In the laser embodiment, there is no need for filters since the light is monochromatic. Also this embodiment does not require the use of a figid light guide since flexible light guides are readily available for laser applications and a low divergence laser beam can be easily focused into a small diameter optical fiber. The use of multiple pulses may be particularly useful to- overcome the limited lasing level in the laser embodiment of the invention.
The cutaneous resurfacing method in accordance with the present invention includes an Er:YAG laser light, whose radiation has an absorption depth of much less than that of CO2 laser radiation, of the order of 50 micron is used. Despite the relatively low absorption depth, an appropriate peeling depth is reached by providing multiple pulses. The thickness of the layer of evaporated tissue may be controlled by the number of pulses, the delay between pulses and varying pulse parameters.
Er:YAG lasers produce radiation of 2.94pm, with an energy per pulse of up to 1J. Absorption depth of the radiation is typically about 10}un. Thus, to evaporate an epidermis, a train of pulses should be used. Typical delay between the laser pulses should be in the range of 0.5-lOmsec. The time should preferably be shorter than, or on the order of, the epidermis thermal relaxation time.
Thus, it should be apparent that there has been provided in accordance with the present invention a treatment device that:includes a flashlamp or a near -infrared pulsed laser.in another embodiment, an Er:YAG laser and a coupler that fully satisfy the objectives and advantages set forth above. Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art.
Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.
Claims (18)
1. An apparatus for treating a region of skin comprising;
a pulsed light source for heating and shrinking the collagen in the region of skin to a degree sufficient to reduce wrinkles in the region of skin;
a housing in which the pulsed light source is disposed, wherein the housing includes an aperture disposed with respect to the pulsed light source to direct light emitted from the light source to the region of skin; and a timer, connected to the pulsed light source, for indicating when a delay time has passed after an application of a cooling substance to the skin region.
a pulsed light source for heating and shrinking the collagen in the region of skin to a degree sufficient to reduce wrinkles in the region of skin;
a housing in which the pulsed light source is disposed, wherein the housing includes an aperture disposed with respect to the pulsed light source to direct light emitted from the light source to the region of skin; and a timer, connected to the pulsed light source, for indicating when a delay time has passed after an application of a cooling substance to the skin region.
2. An apparatus according to claim 1, wherein the pulsed light source comprises a microprocessor for determining the delay time in response to a selected skin temperature profile.
3. An apparatus according to claim 1, wherein the pulsed light source comprises a microprocessor for determining the delay time in response to a selected collagen heating depth.
4. An apparatus according to any one of claims 1 to 3 further comprising means for reducing the temperature of the cooling substance, wherein the cooling means is disposed to provide a signal indicative of cooling to the timer.
5. An apparatus according to any one of claims 1 to 4 further comprising a pulse formation circuit and a pulse duration input, wherein the pulse duration circuit is coupled to the pulsed light source and is adapted to control the duration of pulses emitted by the pulsed light source in response to the pulse duration input.
6. An apparatus according to any one of claims 1 to 5, wherein the pulsed light source comprises a laser.
7. An apparatus according to 6, wherein the laser is selected from the group consisting of a Nd (Yag) laser and a ruby laser.
8. An apparatus according to any one of claims 1 to 5, wherein the pulsed light source comprises a noncoherent light source.
9. An apparatus according to any one of claims 1 to 8, further comprising a filter disposed adjacent to the aperture, wherein a temperature distribution within the skin is controlled in response to a radiation spectrum produced by filtering the light.
10. An apparatus according to claim 9, wherein the filter is of the type that only eliminates light having a wavelength outside the range of 600-1200nm.
11. An apparatus according to any one of claims 1 to 10, further comprising a flexible light guide attached adjacent to the aperture.
12. An apparatus according to any one of claims 1 to 10, further comprising a rigid light guide attached adjacent to the aperture.
13. An apparatus according to any one of claims 1 to 12, further comprising a pulse delay in the range of 0.5-10 msec between successive pulses of light emitted by the pulsed light source.
14. Use of the apparatus of any one of claims 1 to 13 for treating a region of skin.
15. An apparatus for skin rejuvenation by removing at least an outer layer of skin in a region of skin comprising:
an Er:YAG laser light source disposed in a housing capable of directing light to the region of skin for a duration and with an intensity sufficient to remove the outer layer;
a pulse forming circuit coupled to the Er:YAG laser light source including a pulse delay circuit for providing a delay between sequential pulses of Er:YAG light for a period of time not less than the thermal relaxation time of the skin.
an Er:YAG laser light source disposed in a housing capable of directing light to the region of skin for a duration and with an intensity sufficient to remove the outer layer;
a pulse forming circuit coupled to the Er:YAG laser light source including a pulse delay circuit for providing a delay between sequential pulses of Er:YAG light for a period of time not less than the thermal relaxation time of the skin.
16. An apparatus according to claim 15, wherein the pulse delay circuit produces a delay in the range of 0.5-10 msec between pulses.
17. An apparatus according to claim 15 or claim 16, wherein the light source is capable of providing pulses having energy fluences on the order of 100 J/cm2.
18. Use of the apparatus of any one of claims 15 to 17 for skin rejuvenation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/529,044 US5964749A (en) | 1995-09-15 | 1995-09-15 | Method and apparatus for skin rejuvenation and wrinkle smoothing |
US08/529,044 | 1995-09-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2185196A1 CA2185196A1 (en) | 1997-03-16 |
CA2185196C true CA2185196C (en) | 2010-03-09 |
Family
ID=24108276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002185196A Expired - Lifetime CA2185196C (en) | 1995-09-15 | 1996-09-10 | Method and apparatus for skin rejuvenation and wrinkle smoothing |
Country Status (9)
Country | Link |
---|---|
US (2) | US5964749A (en) |
EP (1) | EP0763371B1 (en) |
JP (1) | JP3688070B2 (en) |
KR (1) | KR970014789A (en) |
AT (1) | ATE273728T1 (en) |
AU (1) | AU726267B2 (en) |
CA (1) | CA2185196C (en) |
DE (1) | DE69633159T2 (en) |
DK (1) | DK0763371T3 (en) |
Families Citing this family (285)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5964749A (en) * | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
US7115123B2 (en) * | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
US6350276B1 (en) | 1996-01-05 | 2002-02-26 | Thermage, Inc. | Tissue remodeling apparatus containing cooling fluid |
US7189230B2 (en) * | 1996-01-05 | 2007-03-13 | Thermage, Inc. | Method for treating skin and underlying tissue |
US7229436B2 (en) | 1996-01-05 | 2007-06-12 | Thermage, Inc. | Method and kit for treatment of tissue |
US20040000316A1 (en) * | 1996-01-05 | 2004-01-01 | Knowlton Edward W. | Methods for creating tissue effect utilizing electromagnetic energy and a reverse thermal gradient |
US7006874B2 (en) * | 1996-01-05 | 2006-02-28 | Thermage, Inc. | Treatment apparatus with electromagnetic energy delivery device and non-volatile memory |
US7267675B2 (en) * | 1996-01-05 | 2007-09-11 | Thermage, Inc. | RF device with thermo-electric cooler |
US7452358B2 (en) * | 1996-01-05 | 2008-11-18 | Thermage, Inc. | RF electrode assembly for handpiece |
US20030212393A1 (en) * | 1996-01-05 | 2003-11-13 | Knowlton Edward W. | Handpiece with RF electrode and non-volatile memory |
US7141049B2 (en) * | 1999-03-09 | 2006-11-28 | Thermage, Inc. | Handpiece for treatment of tissue |
KR100376650B1 (en) * | 1996-04-09 | 2003-08-25 | 싸이노슈어, 인코포레이티드 | Alexander laser system for the treatment of skin pathological specimens |
US6547781B1 (en) * | 1996-04-09 | 2003-04-15 | Cynsure, Inc. | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
US6096029A (en) * | 1997-02-24 | 2000-08-01 | Laser Skin Toner, Inc. | Laser method for subsurface cutaneous treatment |
US6106514A (en) * | 1996-08-12 | 2000-08-22 | O'donnell, Jr.; Francis E. | Laser method for subsurface cutaneous treatment |
GB9618051D0 (en) | 1996-08-29 | 1996-10-09 | Sls Wales Ltd | Wrinkle removal |
IL119683A (en) * | 1996-11-25 | 2002-12-01 | Rachel Lubart | Method and device for light irradiation into tissue |
US6653618B2 (en) | 2000-04-28 | 2003-11-25 | Palomar Medical Technologies, Inc. | Contact detecting method and apparatus for an optical radiation handpiece |
US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US7204832B2 (en) * | 1996-12-02 | 2007-04-17 | Pálomar Medical Technologies, Inc. | Cooling system for a photo cosmetic device |
US5810801A (en) * | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
EP0885629A3 (en) | 1997-06-16 | 1999-07-21 | Danish Dermatologic Development A/S | Light pulse generating apparatus and cosmetic and therapeutic phototreatment |
JP4014255B2 (en) * | 1997-07-31 | 2007-11-28 | 有限会社開発顧問室 | Laser irradiation device for skin treatment |
WO2000053261A1 (en) * | 1999-03-08 | 2000-09-14 | Asah Medico A/S | An apparatus for tissue treatment and having a monitor for display of tissue features |
US6074382A (en) | 1997-08-29 | 2000-06-13 | Asah Medico A/S | Apparatus for tissue treatment |
US20080027328A1 (en) * | 1997-12-29 | 2008-01-31 | Julia Therapeutics, Llc | Multi-focal treatment of skin with acoustic energy |
US20060184071A1 (en) * | 1997-12-29 | 2006-08-17 | Julia Therapeutics, Llc | Treatment of skin with acoustic energy |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US6113559A (en) * | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
AUPP176898A0 (en) * | 1998-02-12 | 1998-03-05 | Moldflow Pty Ltd | Automated machine technology for thermoplastic injection molding |
EP1062001B1 (en) | 1998-03-12 | 2005-07-27 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
WO1999049937A1 (en) | 1998-03-27 | 1999-10-07 | The General Hospital Corporation | Method and apparatus for the selective targeting of lipid-rich tissues |
DE19823947A1 (en) * | 1998-05-28 | 1999-12-02 | Baasel Carl Lasertech | Method and device for superficial heating of tissue |
US6077294A (en) | 1998-06-11 | 2000-06-20 | Cynosure, Inc. | Method for non-invasive wrinkle removal and skin treatment |
US6595986B2 (en) | 1998-10-15 | 2003-07-22 | Stephen Almeida | Multiple pulse photo-dermatological device |
US6059820A (en) | 1998-10-16 | 2000-05-09 | Paradigm Medical Corporation | Tissue cooling rod for laser surgery |
US20060212025A1 (en) | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6283956B1 (en) | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
US9192780B2 (en) * | 1998-11-30 | 2015-11-24 | L'oreal | Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders |
US6514242B1 (en) * | 1998-12-03 | 2003-02-04 | David Vasily | Method and apparatus for laser removal of hair |
US6692517B2 (en) * | 1999-01-15 | 2004-02-17 | Cynosure, Inc. | Optical radiation treatment for enhancement of wound healing |
US6210426B1 (en) * | 1999-01-15 | 2001-04-03 | Cynosure Inc | Optical radiation treatment for prevention of surgical scars |
GB9905173D0 (en) * | 1999-03-05 | 1999-04-28 | Sls Biophile Limited | Wrinkle reduction |
US20020156471A1 (en) * | 1999-03-09 | 2002-10-24 | Stern Roger A. | Method for treatment of tissue |
US6569155B1 (en) * | 1999-03-15 | 2003-05-27 | Altus Medical, Inc. | Radiation delivery module and dermal tissue treatment method |
US7041094B2 (en) | 1999-03-15 | 2006-05-09 | Cutera, Inc. | Tissue treatment device and method |
GB9912877D0 (en) * | 1999-06-04 | 1999-08-04 | Sls Biophile Limited | Tissue rejuvenation |
CA2471783A1 (en) * | 1999-06-30 | 2003-07-03 | Edward W. Knowlton | Liquid cooled rf handpiece |
US7354423B2 (en) * | 1999-08-09 | 2008-04-08 | J&J Consumer Co., Inc. | Skin abrasion system and method |
US6645184B1 (en) | 1999-08-09 | 2003-11-11 | Brian D. Zelickson | Tape stripping system and method |
US6404787B1 (en) | 1999-12-21 | 2002-06-11 | General Electric Company | Method and apparatus to select a predetermined number of pulses from a laser |
AU784423B2 (en) * | 2000-01-25 | 2006-03-30 | General Hospital Corporation, The | Method and apparatus for medical treatment utilizing long duration electromagnetic radiation |
US7083610B1 (en) * | 2000-06-07 | 2006-08-01 | Laserscope | Device for irradiating tissue |
US6702838B1 (en) | 2000-09-18 | 2004-03-09 | Lumenis Inc. | Method of treating hypotrophic scars enlarged pores |
US6702808B1 (en) | 2000-09-28 | 2004-03-09 | Syneron Medical Ltd. | Device and method for treating skin |
AU2002245163A1 (en) * | 2000-10-20 | 2002-07-24 | Photomedex | Controlled dose delivery of ultraviolet light for treating skin disorders |
US6808532B2 (en) * | 2000-12-15 | 2004-10-26 | Dan E. Andersen | Laser treatment for reducing wrinkles |
US6746444B2 (en) | 2000-12-18 | 2004-06-08 | Douglas J. Key | Method of amplifying a beneficial selective skin response to light energy |
CA2433022C (en) * | 2000-12-28 | 2016-12-06 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic emr treatment of the skin |
US6673095B2 (en) | 2001-02-12 | 2004-01-06 | Wound Healing Of Oklahoma, Inc. | Apparatus and method for delivery of laser light |
WO2002072199A1 (en) | 2001-03-08 | 2002-09-19 | Optomed Optomedical Systems Gmbh | Irradiation arrangement and method for the treatment of acne and acne scars |
DE10123926A1 (en) | 2001-03-08 | 2002-09-19 | Optomed Optomedical Systems Gmbh | irradiation device |
WO2003003903A2 (en) | 2001-07-02 | 2003-01-16 | Palomar Medical Technologies, Inc. | Laser device for medical/cosmetic procedures |
US20030069569A1 (en) | 2001-08-29 | 2003-04-10 | Burdette Everette C. | Ultrasound device for treatment of intervertebral disc tissue |
US7144248B2 (en) * | 2001-10-18 | 2006-12-05 | Irwin Dean S | Device for oral UV photo-therapy |
US7534255B1 (en) | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
US7303578B2 (en) * | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
US8308784B2 (en) | 2006-08-24 | 2012-11-13 | Jackson Streeter | Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease |
US9993659B2 (en) | 2001-11-01 | 2018-06-12 | Pthera, Llc | Low level light therapy for enhancement of neurologic function by altering axonal transport rate |
US10683494B2 (en) | 2001-11-01 | 2020-06-16 | Pthera LLC | Enhanced stem cell therapy and stem cell production through the administration of low level light energy |
US7762965B2 (en) * | 2001-12-10 | 2010-07-27 | Candela Corporation | Method and apparatus for vacuum-assisted light-based treatments of the skin |
US7762964B2 (en) * | 2001-12-10 | 2010-07-27 | Candela Corporation | Method and apparatus for improving safety during exposure to a monochromatic light source |
US7935139B2 (en) * | 2001-12-10 | 2011-05-03 | Candela Corporation | Eye safe dermatological phototherapy |
EP1627662B1 (en) | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
DE60231653D1 (en) * | 2001-12-10 | 2009-04-30 | Inolase 2002 Ltd | Device for extracting air and condensed steam near a skin target area |
US20040082940A1 (en) * | 2002-10-22 | 2004-04-29 | Michael Black | Dermatological apparatus and method |
US20030216719A1 (en) * | 2001-12-12 | 2003-11-20 | Len Debenedictis | Method and apparatus for treating skin using patterns of optical energy |
US20030109787A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser diagnostics |
US20030109860A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser treatment |
US10695577B2 (en) * | 2001-12-21 | 2020-06-30 | Photothera, Inc. | Device and method for providing phototherapy to the heart |
US7464781B2 (en) * | 2002-02-22 | 2008-12-16 | Bombardier Recreational Product Inc. | Three-wheeled vehicle having a split radiator and an interior storage compartment |
US8840608B2 (en) * | 2002-03-15 | 2014-09-23 | The General Hospital Corporation | Methods and devices for selective disruption of fatty tissue by controlled cooling |
MXPA04008992A (en) | 2002-03-15 | 2005-10-18 | Gen Hospital Corp | Methods and devices for selective disruption of fatty tissue by controlled cooling. |
BR0312430A (en) | 2002-06-19 | 2005-04-26 | Palomar Medical Tech Inc | Method and apparatus for treating skin and subcutaneous conditions |
GB2390025B (en) * | 2002-06-28 | 2005-07-27 | Lynton Lasers Ltd | Dermatological treatment apparatus and method |
US7740600B2 (en) * | 2002-08-02 | 2010-06-22 | Candela Corporation | Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment |
US20080131968A1 (en) * | 2002-08-28 | 2008-06-05 | Nomir Medical Technologies, Inc. | Near-infrared electromagnetic modification of cellular steady-state membrane potentials |
US20040156743A1 (en) * | 2002-08-28 | 2004-08-12 | Eric Bornstein | Near infrared microbial elimination laser system |
US8506979B2 (en) | 2002-08-28 | 2013-08-13 | Nomir Medical Technologies, Inc. | Near-infrared electromagnetic modification of cellular steady-state membrane potentials |
US20040126272A1 (en) * | 2002-08-28 | 2004-07-01 | Eric Bornstein | Near infrared microbial elimination laser system |
US7713294B2 (en) | 2002-08-28 | 2010-05-11 | Nomir Medical Technologies, Inc. | Near infrared microbial elimination laser systems (NIMEL) |
DE60313353T2 (en) * | 2002-10-04 | 2007-08-16 | Photokinetix Inc. | PHOTOKINETIC DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES USING PULSATIVE INKOHAERENTEM LIGHT. |
CN1708261B (en) | 2002-10-23 | 2012-07-04 | 帕洛玛医疗技术公司 | Phototreatment device for use with coolants and topical substances |
US6824542B2 (en) * | 2002-11-08 | 2004-11-30 | Harvey H. Jay | Temporary hair removal method |
US7699058B1 (en) | 2002-11-08 | 2010-04-20 | Jay Harvey H | Hair treatment method |
US7931028B2 (en) | 2003-08-26 | 2011-04-26 | Jay Harvey H | Skin injury or damage prevention method using optical radiation |
US6916316B2 (en) * | 2002-11-08 | 2005-07-12 | Harvey H. Jay | Hair treatment method |
US7255560B2 (en) * | 2002-12-02 | 2007-08-14 | Nomir Medical Technologies, Inc. | Laser augmented periodontal scaling instruments |
US7041109B2 (en) * | 2002-12-12 | 2006-05-09 | Kelsey, Inc. | Apparatus and method for interstitial laser therapy of small breast cancers and adjunctive therapy |
US6991644B2 (en) * | 2002-12-12 | 2006-01-31 | Cutera, Inc. | Method and system for controlled spatially-selective epidermal pigmentation phototherapy with UVA LEDs |
US6981970B2 (en) * | 2002-12-16 | 2006-01-03 | Msq (M2) Ltd. | Device and method for treating skin |
JP2006510407A (en) * | 2002-12-18 | 2006-03-30 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | A device for treating human skin with radiation |
US20040147985A1 (en) * | 2003-01-27 | 2004-07-29 | Altus Medical, Inc. | Dermatological treatment flashlamp device and method |
US20050177141A1 (en) * | 2003-01-27 | 2005-08-11 | Davenport Scott A. | System and method for dermatological treatment gas discharge lamp with controllable current density |
EP1610866A2 (en) * | 2003-02-10 | 2006-01-04 | Palomar Medical Technologies, Inc. | Light emitting oral appliance and method of use |
US20070179481A1 (en) * | 2003-02-14 | 2007-08-02 | Reliant Technologies, Inc. | Laser System for Treatment of Skin Laxity |
US7703458B2 (en) * | 2003-02-21 | 2010-04-27 | Cutera, Inc. | Methods and devices for non-ablative laser treatment of dermatologic conditions |
EP1613202B1 (en) | 2003-03-27 | 2011-02-09 | The General Hospital Corporation | Apparatus for dermatological treatment and fractional skin resurfacing |
US7344555B2 (en) | 2003-04-07 | 2008-03-18 | The United States Of America As Represented By The Department Of Health And Human Services | Light promotes regeneration and functional recovery after spinal cord injury |
KR20060041161A (en) * | 2003-04-10 | 2006-05-11 | 라이트 바이오사이언스, 엘엘씨 | Photomodulation methods and devices for regulating cell proliferation and gene expression |
US7470124B2 (en) * | 2003-05-08 | 2008-12-30 | Nomir Medical Technologies, Inc. | Instrument for delivery of optical energy to the dental root canal system for hidden bacterial and live biofilm thermolysis |
US7291140B2 (en) | 2003-07-18 | 2007-11-06 | Cutera, Inc. | System and method for low average power dermatologic light treatment device |
EP1648385B1 (en) | 2003-07-31 | 2016-05-04 | Gentlewaves Llc | System and method for the photodynamic treatment of skin |
IL157229A (en) * | 2003-08-04 | 2006-08-20 | Zamir Tribelsky | Method for energy coupling especially useful for disinfecting and various systems using it |
US8915906B2 (en) | 2003-08-25 | 2014-12-23 | Cutera, Inc. | Method for treatment of post-partum abdominal skin redundancy or laxity |
US7722600B2 (en) | 2003-08-25 | 2010-05-25 | Cutera, Inc. | System and method for heating skin using light to provide tissue treatment |
US8870856B2 (en) | 2003-08-25 | 2014-10-28 | Cutera, Inc. | Method for heating skin using light to provide tissue treatment |
JP2005080747A (en) * | 2003-09-05 | 2005-03-31 | Nippon Lumenis:Kk | Skin aging preventing method with powerful pulsing ray |
US7326199B2 (en) | 2003-12-22 | 2008-02-05 | Cutera, Inc. | System and method for flexible architecture for dermatologic treatments utilizing multiple light sources |
US7282060B2 (en) | 2003-12-23 | 2007-10-16 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling laser-induced tissue treatment |
US7184184B2 (en) * | 2003-12-31 | 2007-02-27 | Reliant Technologies, Inc. | High speed, high efficiency optical pattern generator using rotating optical elements |
US20050143792A1 (en) * | 2003-12-24 | 2005-06-30 | Harvey Jay | Hair treatment method |
US7372606B2 (en) | 2003-12-31 | 2008-05-13 | Reliant Technologies, Inc. | Optical pattern generator using a single rotating component |
US20050143754A1 (en) * | 2003-12-31 | 2005-06-30 | Zelickson Brian D. | Skin abrasion system and method |
US7196831B2 (en) * | 2003-12-31 | 2007-03-27 | Reliant Technologies, Inc. | Two-dimensional optical scan system using a counter-rotating disk scanner |
US7220254B2 (en) * | 2003-12-31 | 2007-05-22 | Palomar Medical Technologies, Inc. | Dermatological treatment with visualization |
US7090670B2 (en) * | 2003-12-31 | 2006-08-15 | Reliant Technologies, Inc. | Multi-spot laser surgical apparatus and method |
US7914523B2 (en) * | 2004-02-06 | 2011-03-29 | Clinique Dr Daniel Barolet Inc. | Method for the treatment of mammalian tissues |
US20060212029A1 (en) * | 2004-02-20 | 2006-09-21 | Arcusa Villacampa Francisco J | Equipment and method for reducing and eliminating wrinkles in the skin |
AU2005231443B2 (en) | 2004-04-01 | 2012-02-23 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
US7842029B2 (en) | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
US20070179482A1 (en) * | 2004-05-07 | 2007-08-02 | Anderson Robert S | Apparatuses and methods to treat biological external tissue |
US8571648B2 (en) * | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
US20050251117A1 (en) * | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method for treating biological external tissue |
US7413572B2 (en) | 2004-06-14 | 2008-08-19 | Reliant Technologies, Inc. | Adaptive control of optical pulses for laser medicine |
US9161815B2 (en) * | 2004-06-21 | 2015-10-20 | Kilolambda Technologies Ltd. | Dermatological laser system and Method for Skin Resurfacing |
US20110160712A1 (en) * | 2004-07-12 | 2011-06-30 | Nikolai Tankovich | Laser treatment system and method for producing thermal cavities and energy droplets |
US7837675B2 (en) * | 2004-07-22 | 2010-11-23 | Shaser, Inc. | Method and device for skin treatment with replaceable photosensitive window |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
ES2643864T3 (en) | 2004-10-06 | 2017-11-24 | Guided Therapy Systems, L.L.C. | Procedure and system for the treatment of tissues by ultrasound |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
US8690779B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Noninvasive aesthetic treatment for tightening tissue |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
FR2878185B1 (en) * | 2004-11-22 | 2008-11-07 | Sidel Sas | PROCESS FOR MANUFACTURING CONTAINERS COMPRISING A HEATING STEP BY MEANS OF A COHERENT ELECTROMAGNETIC RADIATION BEAM |
US10857722B2 (en) * | 2004-12-03 | 2020-12-08 | Pressco Ip Llc | Method and system for laser-based, wavelength specific infrared irradiation treatment |
US7425296B2 (en) * | 2004-12-03 | 2008-09-16 | Pressco Technology Inc. | Method and system for wavelength specific thermal irradiation and treatment |
US7780656B2 (en) * | 2004-12-10 | 2010-08-24 | Reliant Technologies, Inc. | Patterned thermal treatment using patterned cryogen spray and irradiation by light |
US8277495B2 (en) | 2005-01-13 | 2012-10-02 | Candela Corporation | Method and apparatus for treating a diseased nail |
US7291141B2 (en) * | 2005-02-02 | 2007-11-06 | Jay Harvey H | Method and apparatus for enhancing hair removal |
CA2602835A1 (en) | 2005-03-31 | 2006-10-05 | Esther Mayer | Probe device, system and method for photobiomodulation of tissue lining a body cavity |
EP1776158A1 (en) * | 2005-04-14 | 2007-04-25 | Francesco Peluso | Portable electric stimulator for wrinkles with interchangeable microelectrodes applicator |
US7479136B2 (en) * | 2005-04-14 | 2009-01-20 | Dotson Robert S | Ophthalmic phototherapy treatment method |
US20080269730A1 (en) | 2005-04-14 | 2008-10-30 | Dotson Robert S | Ophthalmic Phototherapy Device and Associated Treatment Method |
US20060235493A1 (en) * | 2005-04-14 | 2006-10-19 | Dotson Robert S | Ophthalmic phototherapy device and associated treatment method |
US20130079759A1 (en) | 2005-04-14 | 2013-03-28 | Robert S. Dotson | Ophthalmic Phototherapy Device and Associated Treatment Method |
US7856985B2 (en) * | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
AU2006272766A1 (en) * | 2005-07-21 | 2007-02-01 | Nomir Medical Technologies, Inc. | Near infrared microbial elimination laser system (NIMELS) |
US7955262B2 (en) * | 2005-07-26 | 2011-06-07 | Syneron Medical Ltd. | Method and apparatus for treatment of skin using RF and ultrasound energies |
US20070176262A1 (en) * | 2005-08-11 | 2007-08-02 | Ernest Sirkin | Series connection of a diode laser bar |
US20070173799A1 (en) * | 2005-09-01 | 2007-07-26 | Hsia James C | Treatment of fatty tissue adjacent an eye |
CN101309631A (en) | 2005-09-15 | 2008-11-19 | 帕洛玛医疗技术公司 | Skin optical characterization device |
EP1928549B1 (en) | 2005-09-28 | 2014-06-11 | Candela Corporation | Apparatus for treating cellulite |
US20070083190A1 (en) * | 2005-10-11 | 2007-04-12 | Yacov Domankevitz | Compression device for a laser handpiece |
US20080146970A1 (en) * | 2005-12-06 | 2008-06-19 | Julia Therapeutics, Llc | Gel dispensers for treatment of skin with acoustic energy |
US8540703B2 (en) | 2005-12-23 | 2013-09-24 | Lutronic Corporation | Methods for treating skin conditions using laser |
US7891362B2 (en) * | 2005-12-23 | 2011-02-22 | Candela Corporation | Methods for treating pigmentary and vascular abnormalities in a dermal region |
WO2007073024A2 (en) | 2005-12-23 | 2007-06-28 | Max Engineering Ltd. | Method of curing inflammatory acne by using carbon lotion and pulsed laser |
US8048089B2 (en) | 2005-12-30 | 2011-11-01 | Edge Systems Corporation | Apparatus and methods for treating the skin |
JP2009524487A (en) * | 2006-01-24 | 2009-07-02 | ノミール・メディカル・テクノロジーズ・インコーポレーテッド | Optical method and apparatus for the regulation of biochemical processes in adipose tissue |
US20090254154A1 (en) | 2008-03-18 | 2009-10-08 | Luis De Taboada | Method and apparatus for irradiating a surface with pulsed light |
US7575589B2 (en) | 2006-01-30 | 2009-08-18 | Photothera, Inc. | Light-emitting device and method for providing phototherapy to the brain |
US10357662B2 (en) | 2009-02-19 | 2019-07-23 | Pthera LLC | Apparatus and method for irradiating a surface with light |
US10426548B2 (en) * | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
KR100742973B1 (en) * | 2006-02-22 | 2007-07-27 | 주식회사 루트로닉 | Fatty tissue removing using 1444nm beam oscillating nd:yag laser |
US7854754B2 (en) | 2006-02-22 | 2010-12-21 | Zeltiq Aesthetics, Inc. | Cooling device for removing heat from subcutaneous lipid-rich cells |
US7814915B2 (en) * | 2006-03-03 | 2010-10-19 | Cutera, Inc. | Aesthetic treatment for wrinkle reduction and rejuvenation |
US20070212385A1 (en) * | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
WO2007106856A2 (en) * | 2006-03-14 | 2007-09-20 | Allux Medical, Inc. | Phototherapy device and method of providing phototherapy to a body surface |
WO2007109136A2 (en) * | 2006-03-17 | 2007-09-27 | Light Dimensions, Inc. | Light-based enhancing apparatuses and methods of use |
KR100649890B1 (en) * | 2006-03-27 | 2006-11-28 | 주식회사 루트로닉 | Control method and control structure of laser beam irradiation by using a contact sensor |
US8460280B2 (en) * | 2006-04-28 | 2013-06-11 | Cutera, Inc. | Localized flashlamp skin treatments |
EP2018129B1 (en) | 2006-05-12 | 2020-04-01 | Vytronus, Inc. | Device for ablating body tissue |
US20100198065A1 (en) * | 2009-01-30 | 2010-08-05 | VyntronUS, Inc. | System and method for ultrasonically sensing and ablating tissue |
US8246611B2 (en) | 2006-06-14 | 2012-08-21 | Candela Corporation | Treatment of skin by spatial modulation of thermal heating |
WO2008001284A2 (en) | 2006-06-26 | 2008-01-03 | Koninklijke Philips Electronics N.V. | Device and method for the treatment of skin, and use of the device |
EP2043544A4 (en) * | 2006-07-13 | 2010-12-15 | Reliant Technologies Llc | Apparatus and method for adjustable fractional optical dermatological treatment |
US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
US20080161745A1 (en) * | 2006-09-08 | 2008-07-03 | Oliver Stumpp | Bleaching of contrast enhancing agent applied to skin for use with a dermatological treatment system |
US8292935B2 (en) * | 2006-09-12 | 2012-10-23 | Bistitec Pharma Marketing Ltd | Photonic device and method for treating cervical dysplasia |
US8192474B2 (en) | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
US20080161888A1 (en) * | 2007-01-03 | 2008-07-03 | Candela Corporation | Treatment of Skin by Spatial Modulation of Thermal Injury |
WO2008109554A1 (en) | 2007-03-02 | 2008-09-12 | Candela Corporation | Variable depth skin heating with lasers |
FR2913210B1 (en) * | 2007-03-02 | 2009-05-29 | Sidel Participations | IMPROVEMENTS IN THE HEATING OF PLASTIC MATERIALS BY INFRARED RADIATION |
US20080221649A1 (en) * | 2007-03-09 | 2008-09-11 | Agustina Echague | Method of sequentially treating tissue |
US20080234669A1 (en) * | 2007-03-19 | 2008-09-25 | Kauvar Arielle N B | Method and device for treating skin by superficial coagulation |
US10183183B2 (en) * | 2007-04-13 | 2019-01-22 | Acoustic Medsystems, Inc. | Acoustic applicators for controlled thermal modification of tissue |
US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
FR2917005B1 (en) * | 2007-06-11 | 2009-08-28 | Sidel Participations | HEATING FACILITY FOR PREFORMING BODIES FOR BLOWING CONTAINERS |
US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
US8523927B2 (en) | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
US8285390B2 (en) | 2007-08-21 | 2012-10-09 | Zeltiq Aesthetics, Inc. | Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue |
US20090069795A1 (en) * | 2007-09-10 | 2009-03-12 | Anderson Robert S | Apparatus and method for selective treatment of tissue |
US7740651B2 (en) * | 2007-09-28 | 2010-06-22 | Candela Corporation | Vacuum assisted treatment of the skin |
US8920409B2 (en) * | 2007-10-04 | 2014-12-30 | Cutera, Inc. | System and method for dermatological lesion treatment using gas discharge lamp with controllable current density |
US20090093864A1 (en) * | 2007-10-08 | 2009-04-09 | Anderson Robert S | Methods and devices for applying energy to tissue |
KR100958612B1 (en) | 2007-10-09 | 2010-05-18 | 한국전기연구원 | Laser system for medical cure using pulse trains |
WO2009052866A1 (en) * | 2007-10-25 | 2009-04-30 | Pantec Biosolutions Ag | Laser device and method for ablating biological tissue |
JP5508285B2 (en) | 2008-01-04 | 2014-05-28 | エッジ システムズ コーポレーション | Apparatus and method for treating skin |
JP5181791B2 (en) * | 2008-04-03 | 2013-04-10 | ソニー株式会社 | Voltage controlled variable frequency oscillation circuit and signal processing circuit |
GB2459438B (en) * | 2008-04-10 | 2010-10-06 | Kythera Biopharmaceuticals Inc | Systems and methods for transdermal photo-polymerization |
CN104545998B (en) | 2008-06-06 | 2020-07-14 | 奥赛拉公司 | System and method for cosmetic treatment and imaging |
US9155588B2 (en) | 2008-06-13 | 2015-10-13 | Vytronus, Inc. | System and method for positioning an elongate member with respect to an anatomical structure |
US20100152582A1 (en) * | 2008-06-13 | 2010-06-17 | Vytronus, Inc. | Handheld system and method for delivering energy to tissue |
CA2726934C (en) * | 2008-06-14 | 2018-04-24 | Vytronus, Inc. | System and method for delivering energy to tissue |
US20100049099A1 (en) * | 2008-07-18 | 2010-02-25 | Vytronus, Inc. | Method and system for positioning an energy source |
US10363057B2 (en) | 2008-07-18 | 2019-07-30 | Vytronus, Inc. | System and method for delivering energy to tissue |
US7848035B2 (en) | 2008-09-18 | 2010-12-07 | Photothera, Inc. | Single-use lens assembly |
EP2346428B1 (en) | 2008-09-25 | 2019-11-06 | Zeltiq Aesthetics, Inc. | Treatment planning systems and methods for body contouring applications |
US9220924B2 (en) | 2008-10-30 | 2015-12-29 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US8414508B2 (en) | 2008-10-30 | 2013-04-09 | Vytronus, Inc. | System and method for delivery of energy to tissue while compensating for collateral tissue |
US9033885B2 (en) * | 2008-10-30 | 2015-05-19 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US11298568B2 (en) | 2008-10-30 | 2022-04-12 | Auris Health, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US9192789B2 (en) | 2008-10-30 | 2015-11-24 | Vytronus, Inc. | System and method for anatomical mapping of tissue and planning ablation paths therein |
CA2742787C (en) | 2008-11-17 | 2018-05-15 | Vytronus, Inc. | Systems and methods for ablating body tissue |
US8475379B2 (en) * | 2008-11-17 | 2013-07-02 | Vytronus, Inc. | Systems and methods for ablating body tissue |
US8603073B2 (en) | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
JP2012513837A (en) | 2008-12-24 | 2012-06-21 | ガイデッド セラピー システムズ, エルエルシー | Method and system for fat loss and / or cellulite treatment |
US20100179372A1 (en) * | 2009-01-13 | 2010-07-15 | Glassman Harry A | Method of enhancing skin appearance through the combination of Titan TM and TMR methods |
EP2403598A4 (en) * | 2009-03-05 | 2013-07-31 | Cynosure Inc | Pulsed therapeutic light system and method |
KR101701137B1 (en) | 2009-04-30 | 2017-02-01 | 젤티크 애스세틱스, 인코포레이티드. | Device, system and method of removing heat from subcutaneous lipid-rich cells |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
RU2012107673A (en) | 2009-08-04 | 2013-09-10 | Поллоген Лтд. | COSMETIC REJUVENATION OF SKIN |
US20110190745A1 (en) * | 2009-12-04 | 2011-08-04 | Uebelhoer Nathan S | Treatment of sweat glands |
US9314368B2 (en) | 2010-01-25 | 2016-04-19 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associates devices, systems and methods |
CN102843987A (en) * | 2010-04-13 | 2012-12-26 | 国际商业机器公司 | System and method for modification and/or smoothing of tissue with laser ablation |
US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
KR101269970B1 (en) * | 2010-11-15 | 2013-05-31 | 주식회사 루트로닉 | An optical apparatus for skin treatment and a method for controlling the optical apparatus |
US10722395B2 (en) | 2011-01-25 | 2020-07-28 | Zeltiq Aesthetics, Inc. | Devices, application systems and methods with localized heat flux zones for removing heat from subcutaneous lipid-rich cells |
US20130103123A1 (en) | 2011-10-14 | 2013-04-25 | Sazzadur Rahman Khan | Light-Emitting Devices for Wound Healing |
KR102183581B1 (en) | 2012-04-18 | 2020-11-27 | 싸이노슈어, 엘엘씨 | Picosecond laser apparatus and methods for treating target tissues with same |
WO2014028770A1 (en) | 2012-08-15 | 2014-02-20 | Burdette Everette C | Mri compatible ablation catheter system incorporating directional high-intensity ultrasound for treatment |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
US20160296764A1 (en) * | 2014-07-01 | 2016-10-13 | Gary John Bellinger | Non-invasive and non-ablative soft tissue laser therapy |
CN204017181U (en) | 2013-03-08 | 2014-12-17 | 奥赛拉公司 | Aesthstic imaging and processing system, multifocal processing system and perform the system of aesthetic procedure |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
EP2967633B1 (en) | 2013-03-15 | 2018-04-25 | Edge Systems LLC | Devices for treating the skin |
EP2973894A2 (en) | 2013-03-15 | 2016-01-20 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
US9861442B2 (en) | 2013-03-15 | 2018-01-09 | Nikolai Tankovich | Laser filler |
US10575890B2 (en) | 2014-01-31 | 2020-03-03 | Zeltiq Aesthetics, Inc. | Treatment systems and methods for affecting glands and other targeted structures |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
EP3131630B1 (en) | 2014-04-18 | 2023-11-29 | Ulthera, Inc. | Band transducer ultrasound therapy |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
WO2016040534A1 (en) | 2014-09-09 | 2016-03-17 | LumiThera, Inc. | Multi-wavelength phototherapy devices, systems, and methods for the non-invasive treatment of damaged or diseased tissue |
EP4324414A2 (en) | 2014-12-23 | 2024-02-21 | HydraFacial LLC | Devices and methods for treating the skin using a rollerball or a wicking member |
WO2017070112A1 (en) | 2015-10-19 | 2017-04-27 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
EP3399950A1 (en) | 2016-01-07 | 2018-11-14 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
US10420955B2 (en) | 2016-01-18 | 2019-09-24 | Nikolai Tankovich | Attachable tip for laser hand piece |
PL3405294T3 (en) | 2016-01-18 | 2023-05-08 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
CN114631846A (en) | 2016-08-16 | 2022-06-17 | 奥赛拉公司 | System and method for cosmetic ultrasound treatment of skin |
US11076879B2 (en) | 2017-04-26 | 2021-08-03 | Zeltiq Aesthetics, Inc. | Shallow surface cryotherapy applicators and related technology |
US10632324B2 (en) | 2017-04-27 | 2020-04-28 | 9127-4910 Quebec Inc. | Method for the treatment of skin tissues |
US11944849B2 (en) | 2018-02-20 | 2024-04-02 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
SG11202008151QA (en) | 2018-02-26 | 2020-09-29 | Cynosure Inc | Q-switched cavity dumped sub-nanosecond laser |
CA3107932A1 (en) | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
USD1016615S1 (en) | 2021-09-10 | 2024-03-05 | Hydrafacial Llc | Container for a skin treatment device |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB710484A (en) * | 1949-08-04 | 1954-06-16 | Maria Ruttger Pelli | Apparatus for the treatment of the skin |
DE2609273A1 (en) * | 1976-03-05 | 1977-09-08 | Mutzhas Maximilian F | IRRADIATION DEVICE WITH ULTRAVIOLET RADIATION SOURCE |
US4022534A (en) * | 1976-03-23 | 1977-05-10 | Kollmorgen Corporation | Reflectometer optical system |
JPS56109654A (en) * | 1980-02-01 | 1981-08-31 | Kuraray Co | Dermatological laser treating device |
HU186081B (en) * | 1981-09-02 | 1985-05-28 | Fenyo Marta | Process and apparatus for stimulating healing of pathologic points on the surface of the body first of all of wounds, ulcera and other epithelial lesions |
US4784135A (en) * | 1982-12-09 | 1988-11-15 | International Business Machines Corporation | Far ultraviolet surgical and dental procedures |
US4608978A (en) * | 1983-09-26 | 1986-09-02 | Carol Block Limited | Method and apparatus for photoepiltion |
US5409479A (en) * | 1983-10-06 | 1995-04-25 | Premier Laser Systems, Inc. | Method for closing tissue wounds using radiative energy beams |
JPS62500626A (en) * | 1984-10-25 | 1987-03-12 | キャンデラ・レ−ザ−・コ−ポレ−ション | Method and apparatus for amplifying light to generate a pulsed output beam of light |
US4976709A (en) * | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
US5137530A (en) * | 1985-09-27 | 1992-08-11 | Sand Bruce J | Collagen treatment apparatus |
US5336217A (en) | 1986-04-24 | 1994-08-09 | Institut National De La Sante Et De La Recherche Medicale (Insepm) | Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias |
US4757431A (en) * | 1986-07-01 | 1988-07-12 | Laser Media | Off-axis application of concave spherical reflectors as condensing and collecting optics |
US5259380A (en) * | 1987-11-04 | 1993-11-09 | Amcor Electronics, Ltd. | Light therapy system |
US4930504A (en) * | 1987-11-13 | 1990-06-05 | Diamantopoulos Costas A | Device for biostimulation of tissue and method for treatment of tissue |
DE3906860A1 (en) * | 1988-03-08 | 1989-09-28 | Fraunhofer Ges Forschung | Device for producing an angiography |
EP0368512A3 (en) * | 1988-11-10 | 1990-08-08 | Premier Laser Systems, Inc. | Multiwavelength medical laser system |
US5161526A (en) * | 1989-04-04 | 1992-11-10 | Hellwing Isak A | Method of treating of bleeding in hemophiliacs |
US5486172A (en) * | 1989-05-30 | 1996-01-23 | Chess; Cyrus | Apparatus for treating cutaneous vascular lesions |
US5057104A (en) * | 1989-05-30 | 1991-10-15 | Cyrus Chess | Method and apparatus for treating cutaneous vascular lesions |
US4950880A (en) * | 1989-07-28 | 1990-08-21 | Recon/Optical, Inc. | Synthetic aperture optical imaging system |
SE465953B (en) * | 1990-04-09 | 1991-11-25 | Morgan Gustafsson | DEVICE FOR TREATMENT OF UNDESECTED EXTERNAL ACCOMMODATIONS |
US5207671A (en) * | 1991-04-02 | 1993-05-04 | Franken Peter A | Laser debridement of wounds |
US5769844A (en) * | 1991-06-26 | 1998-06-23 | Ghaffari; Shahriar | Conventional light-pumped high power system for medical applications |
US5217455A (en) * | 1991-08-12 | 1993-06-08 | Tan Oon T | Laser treatment method for removing pigmentations, lesions, and abnormalities from the skin of a living human |
JP2616615B2 (en) * | 1991-10-24 | 1997-06-04 | 松下電器産業株式会社 | Semiconductor laser treatment device |
US5226907A (en) | 1991-10-29 | 1993-07-13 | Tankovich Nikolai I | Hair removal device and method |
US5344418A (en) * | 1991-12-12 | 1994-09-06 | Shahriar Ghaffari | Optical system for treatment of vascular lesions |
IL100545A (en) * | 1991-12-29 | 1995-03-15 | Dimotech Ltd | Apparatus for photodynamic therapy treatment |
US5405368A (en) * | 1992-10-20 | 1995-04-11 | Esc Inc. | Method and apparatus for therapeutic electromagnetic treatment |
CA2093055C (en) * | 1992-04-09 | 2002-02-19 | Shimon Eckhouse | Method and apparatus for therapeutic electromagnetic treatment |
US5527350A (en) | 1993-02-24 | 1996-06-18 | Star Medical Technologies, Inc. | Pulsed infrared laser treatment of psoriasis |
US5591157A (en) * | 1994-09-07 | 1997-01-07 | Hennings; David R. | Method and apparatus for tympanic membrane shrinkage |
US5611795A (en) * | 1995-02-03 | 1997-03-18 | Laser Industries, Ltd. | Laser facial rejuvenation |
US5660836A (en) * | 1995-05-05 | 1997-08-26 | Knowlton; Edward W. | Method and apparatus for controlled contraction of collagen tissue |
US5964749A (en) * | 1995-09-15 | 1999-10-12 | Esc Medical Systems Ltd. | Method and apparatus for skin rejuvenation and wrinkle smoothing |
-
1995
- 1995-09-15 US US08/529,044 patent/US5964749A/en not_active Expired - Lifetime
-
1996
- 1996-08-27 AU AU64310/96A patent/AU726267B2/en not_active Ceased
- 1996-09-10 CA CA002185196A patent/CA2185196C/en not_active Expired - Lifetime
- 1996-09-11 DE DE69633159T patent/DE69633159T2/en not_active Expired - Lifetime
- 1996-09-11 DK DK96306588T patent/DK0763371T3/en active
- 1996-09-11 AT AT96306588T patent/ATE273728T1/en not_active IP Right Cessation
- 1996-09-11 EP EP96306588A patent/EP0763371B1/en not_active Expired - Lifetime
- 1996-09-13 JP JP24369696A patent/JP3688070B2/en not_active Expired - Fee Related
- 1996-09-14 KR KR1019960039986A patent/KR970014789A/en not_active Application Discontinuation
-
1999
- 1999-05-10 US US09/307,874 patent/US6387089B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU6431096A (en) | 1997-03-20 |
DK0763371T3 (en) | 2005-02-28 |
AU726267B2 (en) | 2000-11-02 |
EP0763371B1 (en) | 2004-08-18 |
DE69633159D1 (en) | 2004-09-23 |
EP0763371A2 (en) | 1997-03-19 |
US5964749A (en) | 1999-10-12 |
DE69633159T2 (en) | 2005-09-08 |
ATE273728T1 (en) | 2004-09-15 |
EP0763371A3 (en) | 1999-04-14 |
US6387089B1 (en) | 2002-05-14 |
CA2185196A1 (en) | 1997-03-16 |
KR970014789A (en) | 1997-04-28 |
JP3688070B2 (en) | 2005-08-24 |
JPH09103507A (en) | 1997-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2185196C (en) | Method and apparatus for skin rejuvenation and wrinkle smoothing | |
US7465307B2 (en) | Tissue treatment system | |
US6451007B1 (en) | Thermal quenching of tissue | |
US6666856B2 (en) | Hair removal device and method | |
CA2195294C (en) | Method and apparatus for depilation using pulsed electromagnetic radiation | |
CA2171260C (en) | Method and apparatus for depilation using pulsed electromagnetic radiation | |
US5836999A (en) | Method and apparatus for treating psoriasis using pulsed electromagnetic radiation | |
US5776175A (en) | Method and apparatus for treatment of cancer using pulsed electromagnetic radiation | |
CA2239773C (en) | Pulsed light source for removing biological tissue | |
EP2578175A2 (en) | Method and apparatus for producing thermal damage within the skin | |
KR100722248B1 (en) | Laser treatment apparatus by using multipulse laser | |
CA2364104A1 (en) | Skin wrinkle reduction using pulsed light | |
Lanigan | Therapeutic Applications: Dermatology—Selective Photothermolysis | |
O’Connor et al. | Understanding Lasers, Light Sources, and Other Energy-Based Technology |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20160912 |