CA2188952A1 - Single-piston, multi-mode fluid displacement pump - Google Patents
Single-piston, multi-mode fluid displacement pumpInfo
- Publication number
- CA2188952A1 CA2188952A1 CA002188952A CA2188952A CA2188952A1 CA 2188952 A1 CA2188952 A1 CA 2188952A1 CA 002188952 A CA002188952 A CA 002188952A CA 2188952 A CA2188952 A CA 2188952A CA 2188952 A1 CA2188952 A1 CA 2188952A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- piston
- pump
- side wall
- seal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
- F04B49/12—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00 by varying the length of stroke of the working members
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B2205/00—Fluid parameters
- F04B2205/09—Flow through the pump
Abstract
A single-piston, multimode fluid displacement pump comprising an elongated chamber, a piston reciprocally mounted within the chamber, a driving mechanism axially aligned with the chamber and piston for a accurately positioning the piston within the chamber so as to define a measured fluid displacement, and ports for aspirating and dispensing fluid.
Description
WO 95130089 ~ 1 ~ 8 9 5 ~ PCT/US95/05199 SINGLE-PISTON, MULTI-MODE FLUID DISPLACEMENT PUMP
BACKGRO~JND OF THE INVENTION
In applirqtiQnc such as mPAirql labo.~ and process in~llu~ nl~l;nn~ it is .- often nF~e~ to provide precisely ,.eas.lled q~qntiti~s of a ~qmp~ )entc, or ~e .~ For example, a very small ~ua~llily of s_ rle~ i.e. several microliters, might be diluted with several hundred mic~ of buffa before being mixed with a 4uantily of reagent.
Very alr~cllr~q-t~ dosa~Ps of Qqmpl~ diluent, and reagent have tr3~itionqlly been provided by fluid ~ A~ nt pumps. Such pumps very q-~u-,t~l~ ...~ the u~-lil~ of fluid ~isplcqced In order to Ill~Ul~ fluid tli~l^^~m~nt ac~;ula~l~l~ it is ~s~ to have a precisely ...~-A-hil-~d pump .i~linder and piston and a precise ,..~.l~ni~m for driving the piston to ~licpl^^e the fluid.
Typically, two dirr. .~nl pumps are n~led: one for the very small qua~ of s~nple and another for the much larger 4uanlily of diluent. Fu~ n~ore, it is typical for the precise driving ~ qni~m to be off-axis from the cylinder and co~ f~t~d to the piston by some ,.-~~ irql linkage such as pulleys and drive belts. ~ ~ the driving ...~.Ahqni~... is off-axis, it may introduce s.~bst~,tial strain against the piston, leading to early failure due to wear on the pump seals.
There is a need for a fluid ~ n~ pump which can accept pistons and ch~...be ~ of varying size, dep~ g on the ~luaillily of fluid needed to be measured.
Ideally, such a pump would be able to .1;spe.-~ both a large ~lual~lily of diluent and a tiny ~luanlil~ of sample. ~dditinn~lly, the pump should have a precision driving...~h~nicm axially aligned with the cylinde~ and piston, in order to COIlSC~Ve space and reduce wear on the seals.
9 ~ 2 -SUMMARY OF THE INVEN IION
A single-piston, multimodç fluid ~ ."~"~ pump compricine an ~
cl~a..~her, a piston ~ >cally ll~uunltd within the ch~...he~, a driving ...~hAn.c...
axially aligned with the ch~ e~ and piston for ~ecu-~t~ly po-citi~nine the piston within the çl-~ be so as to define a ,lleasul~d fluid disrl~cemçnt, and ports for ~C.~ t;~ and ;.cl~ns;ne fluid.
The invention rehtes to a fluid ~licl~l~ce~en~ pump, and particularly to a fluid~lispl~^Pm~.nt pump with multim- de oper~tion~ that is, capable of precisely ~ .n.cin~
both very small ql~ntiti~s of sample and s~ll,s~ lly larger qu~ntities of diluent or system fluid.
An object of the invention is to provide a fluid ~1ispl~^~m~nt pump with a single piston for ~ ely ~ e very small qU~ntitiesc ûf sample.
A second object of the invention is to provide a fluid d~ f ..~n~ pump with a single piston for ~ çly d;~ .c;ne ~ .st~ lly hrger qu~ntiti~s of diluent.
A third object of the invention is to provide a fluid tlilcFl~cpm~nt pump with asingle piston capable of ~u-~çly ~ ;ng either very small ~l~lAn~ s of sample or ,.Jbs~; .l;~lly larger ~lU~n~ 5 of diluent.
Still another object of the invention is to provide a fluid ~ic~ nt pump with a very ac~;u~ç precision driving ...~ m which is s ~bst ~ ly axially aligned with the cylinder and piston, thereby ~luci~e wear on the seals and making the pump more c~ t W O 95/30089 PC~rnUS95/05199 - 21~89~
BACKGRO~JND OF THE INVENTION
In applirqtiQnc such as mPAirql labo.~ and process in~llu~ nl~l;nn~ it is .- often nF~e~ to provide precisely ,.eas.lled q~qntiti~s of a ~qmp~ )entc, or ~e .~ For example, a very small ~ua~llily of s_ rle~ i.e. several microliters, might be diluted with several hundred mic~ of buffa before being mixed with a 4uantily of reagent.
Very alr~cllr~q-t~ dosa~Ps of Qqmpl~ diluent, and reagent have tr3~itionqlly been provided by fluid ~ A~ nt pumps. Such pumps very q-~u-,t~l~ ...~ the u~-lil~ of fluid ~isplcqced In order to Ill~Ul~ fluid tli~l^^~m~nt ac~;ula~l~l~ it is ~s~ to have a precisely ...~-A-hil-~d pump .i~linder and piston and a precise ,..~.l~ni~m for driving the piston to ~licpl^^e the fluid.
Typically, two dirr. .~nl pumps are n~led: one for the very small qua~ of s~nple and another for the much larger 4uanlily of diluent. Fu~ n~ore, it is typical for the precise driving ~ qni~m to be off-axis from the cylinder and co~ f~t~d to the piston by some ,.-~~ irql linkage such as pulleys and drive belts. ~ ~ the driving ...~.Ahqni~... is off-axis, it may introduce s.~bst~,tial strain against the piston, leading to early failure due to wear on the pump seals.
There is a need for a fluid ~ n~ pump which can accept pistons and ch~...be ~ of varying size, dep~ g on the ~luaillily of fluid needed to be measured.
Ideally, such a pump would be able to .1;spe.-~ both a large ~lual~lily of diluent and a tiny ~luanlil~ of sample. ~dditinn~lly, the pump should have a precision driving...~h~nicm axially aligned with the cylinde~ and piston, in order to COIlSC~Ve space and reduce wear on the seals.
9 ~ 2 -SUMMARY OF THE INVEN IION
A single-piston, multimodç fluid ~ ."~"~ pump compricine an ~
cl~a..~her, a piston ~ >cally ll~uunltd within the ch~...he~, a driving ...~hAn.c...
axially aligned with the ch~ e~ and piston for ~ecu-~t~ly po-citi~nine the piston within the çl-~ be so as to define a ,lleasul~d fluid disrl~cemçnt, and ports for ~C.~ t;~ and ;.cl~ns;ne fluid.
The invention rehtes to a fluid ~licl~l~ce~en~ pump, and particularly to a fluid~lispl~^Pm~.nt pump with multim- de oper~tion~ that is, capable of precisely ~ .n.cin~
both very small ql~ntiti~s of sample and s~ll,s~ lly larger qu~ntities of diluent or system fluid.
An object of the invention is to provide a fluid ~1ispl~^~m~nt pump with a single piston for ~ ely ~ e very small qU~ntitiesc ûf sample.
A second object of the invention is to provide a fluid d~ f ..~n~ pump with a single piston for ~ çly d;~ .c;ne ~ .st~ lly hrger qu~ntiti~s of diluent.
A third object of the invention is to provide a fluid tlilcFl~cpm~nt pump with asingle piston capable of ~u-~çly ~ ;ng either very small ~l~lAn~ s of sample or ,.Jbs~; .l;~lly larger ~lU~n~ 5 of diluent.
Still another object of the invention is to provide a fluid ~ic~ nt pump with a very ac~;u~ç precision driving ...~ m which is s ~bst ~ ly axially aligned with the cylinder and piston, thereby ~luci~e wear on the seals and making the pump more c~ t W O 95/30089 PC~rnUS95/05199 - 21~89~
Another object of the invention is to provide a precision driving ...~5h3ni~m with few moving parts that has very little slack or play in it, to enh~nr~ the precision and accuracy and reduce the nulllbc~ of moving mPrl~nirAl parts.
BRIEF DESCRIPIION OF THE DRAWINGS
FIG. 1 is a ~-~lK~1;ve view of the fluid ~isr1~^pm~nt pump.
FIG. 2 is a partially broken away scl.e ..AI;c of one prefcll~ e ..bo~ nt of thefluid ~;s~ .".~nl pump.
FIG. 3 is a par~ally broken away sclu .AI;c of a second plefcll~d e-..~;. .v--t of the fluid ~ 1J1~ ...f nl pump.
FIG. 4 is a pa~ally broken away s hf,..~l;r of a third plcfc.l~d c,,lbodi,~ t of the fluid ~ f...- nl pump.
FIG. S is a par~ally broken away s~ l;r of the fluid ~ f -.. .-t pump in a complete system for ~ n~ ~ the sample and diluent.
FIG. 6 shows the sC~ ;r ~!pe~1ir~n of the pump in ~ e diluent to pdme the pump.
FIG. 7 shows the K~ ;c opf-~.l;n~ of the pump in completing the p-;.--;.
cycle.
r FIG. 8 shows the s~ opP~tion of the pump in ~ At;~e a small ~ y of sample.
'`3 5~ -FIG. 9 shows the ~I~ ;c ope,~lion of the pump in ~c~ l;ng a large ~lua~ y of diluent.
DETAILED DESCRIPIION OF THE ~REFERRED EMBODIM~ITS
The mllltim~e fluid .lispl~ pump is shown genPr~lly as nu~bel 10 in the Figures. FIG. 2 shows a first embo limPnt 12 of the pump 10, which is used for ;ng and li~ -cin~ large volumes of fluid. The pump 10 has a hol-cing 14, which comrricp~s a top wall 16, bottom wall 18 and side wall 20. The top wall 16, bottom wall 18, and side wall 20 enclose an interior 22. The inner surface 24 of the side wall 20 has an annular means or groove 26 in which a seal 28 is ....Ju~-led The seal 28, the inner surface 24 of the side wall 20, and the inner surface 30 of the bottom wall 18 form a C1~5~'her 32. The c~ k~ ~ 32 has a first port 34 and a second port 36 for q~;.i.l;,~g and ~ ;.-g fluids. Mounted l~iplocally within the rhs~lser 32 and sliding through the seal 28 is a piston 38.
The piston 38 is driven and accurately positinn~ lnngitl]-lin~lly within the ch~ 32 by a pos l;on;~g means 40. In the p~f~ d e-..bo~ , the positin means 40 col~ ;~s linear ~st~ q~ol or a stepper motor 42 and a lead screw 44, the lead screw being connr~led to the piston 38. In the plc;~ d embo~imPnt, the positinn means 40 is s ~ ;qlly a~ially aligned with the C]~51~1b... 32 and piston 38.
In oper~tinn of the first e ~l~o~ 12, fluid is ~s~ d into the ~ 5~bC 32 by ~c~ g the motor 42 and lead screw 44 to will~w the piston 38 from the cl~...be 32. This ",o~e.l.~n~ creates a partial v~Cuulll in the ch~mbPr 32, allowing fluid to flow into the c~ - be~ 32 through the first port 34. The amount of fluid d is equal to IIr,2x, where r, is the radius of the piston 38 and x is the fli by which the piston is withdrawn. The lict~nce x can be controlled very ~u~t 1~by the stepper motor and lead screw. Fluid is dicpenc~P~ by a~lv~ncing the piston 38 PCT/US95/0~19 2 ~ ~ g 5 2 lP~J~iS 2 6 AP R 1~96 into the challlber 32, forcing fluid out of the pump through the second port 36. The operation ofthe first port 34 and second port 36 is controlled by a valve (not shown) which permits fluid to enter through the first port 34 and exist through the second port 36. The pump is first primed with fluid, by aspirating and dispensing fluid as described above, to remove all air before operation begins.
FIG. 3 shows a second embodiment 46 of the pump 10, used for aspirating and dispensing small volumes of fluid, wherein the chamber 32 is defined by seal 28 in annular groove 26 at the end of the chamber 32 nearest the positioning means 40, and second seal 47 in a second annular groove 48 in the inner surface 24 of the side wall 20 at the end ofthe chamber 32 nearest the bottom wall 18. The piston 38 further comprises a rod 38 with a step 50, thereby forming a larger diameter segment 52 and a smaller diameter segment 54. The step 50 may be machined so as to create a range of differences in diameter between the larger diameter segment 52 and smaller diameter segment 54, thereby creating a range of fluid displ~cçm.onts. Preferably, the chamber 32 is made narrower at some point along its length so as to accommodate and firmly grip the smaller diameter segment 54 by the second seal 47. Alternatively, the outer diameter of seal 47 may be larger than seal 28 rather than ch~nging chamber dimensions. The chamber 32 has a first port 34 and a second port 36 for a~pilalillg and dispensing fluids.
The piston 38 is driven and accurately positioned longit~l-lin~lly within the chamber 32 by a positioning means 40. In the prefelled embodiment, the positioning means 40 comprises a stepper motor 42 and a lead screw 44, the lead screw being connected to the piston 38. In the preferred embodiment, the positioning means 40 is substantially axially aligned with the chamber 32 and piston 38.
In operation of the second embodiment 46, fluid is aspirated into the chamber 32 by actl1ating the motor 42 and lead screw 44 to withdraw the larger diameter /~ME~IDED ~H~ET
WO 95130089 PCTtUS95tO5199 ...c~nt 52 from the c~ 32. This movement creates a partial vacuum in the c~ b~ 32, allowing fluid to flow into the ch~---hc~ 32 through the first port 34. The amount of fluid ~c~ ~ is equal to (IIrl2- IIr22)x, where r~ is the radius of the larga 1;a.~.fta s~ e-~t r2 is the radius of the smaller .1;5,.~ trr ~~ n~, and % is the ~lict~n~e by which the larger 1;s---~t~r is wi~ldlawn. The ~lict~nr~ X can be controlled very ~ tf-ly by the st~pper motor and lead screw. Fluid is ~ by ad~dr,cing the larger .1i~.f ~ se~...e~-l into the c1.s.~ h~r 32, forcing fluid out of the pump through the second port 36. The operation of the first port 34 and second port 36 is controlled by a valve (not shown) which permits fluid to enter through the first port 34 and exit through the second port 36. The pump is first primed with fluid, by ~ t;ng and ~;~ n~ g fluid as 1pc-crihe~ above, to remove all air before opp~ration begins.
FIG. 4 shows a third ~-.-ho~l;..- ~1 56 of the pump 10, used for Aic~ g both hrge and small qu~ s of fluid, ~h~ there is a first (small) cha~llh r 58 in which the larger di5~f t~ le-ll 52 and the smaller ~1i5.,.. t- r se 111~ nt 54 l~Cipl'~dll~
~e~1~r~ and a second ~arge) chb ..hPr 60 in which the smaller dis ~?t ~ ..t 54 l~Cipl~idLC!i. The first (small) cl~-.h~r 58 is sep~dt~d from the second ~arge) 60 by the seal 61 in an annuhr groove 62 in the inna surface 24 of the side wall 20 and by the smaller di5-"~ tt.,~' S~ 54. The first (small) ~h~ ber 58 has a first port 34 and a second port 36 for ~ g and tli~p~ n~ g fluids. The second (large) chsr~ber 60 has a third port 64 for ~l';'; I;ng and ~i~en~ing fluids. It will be seen that the larger ~;~ -elP~ s~GI~f n~ 52 and smaller fli~"-~ t~ -.l 54 define a first fluid fl~a~ volume in the first (small) C]l'll'bf,- 58 equal to the dirr~n~
~t~n the volume of the larger ~ ll'f h l S~-'f -t 52 and the volume of the smaller 1~;5~ ,r ~c...~.nl 54. The smaller fl;~ - Sf~r.l~ent 54 defines a second fluid p~ mfnt volume in the second ~arge) ch-b-~..b- 60 equal to the volume of the smaller ~ t~;r sf~ -nt 54.
W O 95130089 PC~rrUS95/05199 ~1~8952 -FIG. 5 shows the fluid dis~1a~.~ "enl pump 10 in a co,l,l)lele system for g and ~ g the sample 66 and diluent 68. The flow of fluids thl~u h the 'first port 34, second port 36, and third port 64 is controlled by a valve 70. The valve 70 has a first valve conduit 72 c4~-nr~l~ to the second port 36 of the pump 10 by tubing 74, and a second valve conduit 76 conn?~led to the third port 64 of the pump 10 by tubing 80. The valve 70 also has a third valve conduit 82 connP~d to a source of diluent 88 by tubing 89. The valve 70 also has a rotating T-col-n~or 84 with arms 86 for int~.-~-F~ g the various valve con-l.-;lc. A source of sample 90 is connec'~d to the first port 34 of the pump 10 by tubing 91 and pipette 92, as the pipette 92 dips into the sample 66.
The opP~tinn of the third e."bo l;...- n~ will now be d~ ;bed. It will be seen that two ~r~..t ~l;c~ e~ volu~es are available from the pump 10. As larger ~1;Z~ h, S~,~;Jn~nl 52 is ~~ c~d by the pos;linning means 40 into the first (small) c)~a---lD&r 58, a volume of fluid will be ~icpl~ CÇd equal to (IIr,2- IIr22)x, where r, is the radius of the hrger ~ ,... h' ~ nl, r2 iS the radius of the smaller f~ia.... hr.r ~.~ .,nl, and x is the ~ic~nee by which the larger ~iz...- h~,- se~ nl 52 is advanced. The~i;c~n-~ x may be controlled very ~,~u~ ely by the stepper motor 42 and lead screw 44, or other equivalent po~:l;9n;~g means 40. As the smaller ~;z ..~ set--.f-n~ 54 is a~lv~nced by the positinning means 40 into the second ~arge) c . b~ ~ 60, the smaller ~l;z".~t~r S~'L"'-`~ 54 will displace a volume of fluid egual to IIr22x, where r2 is the radius of the smaller 'l;h'~ s~ l and x is the ~ist~nee by which the s, ~ is a~-vanccd.
The pump 10 is initially primed as follows, as shown in FIG. 6 and FIG. 7.
The valve 70 will make a c4nnr~1;nn A b. h~n the third valve conduit 82 and the second valve conduit 76 by ~s;l;o~ing the T-col-nrc.l~r 84 as shown. The smaller~1;z...l ~nr s~ - -t 54 will be withdrawn from the second (large) cl-~-..b~l 60 by the motor 42 in the d-.eclion as shown by the arrow B. As the smaller ~i~...P~. r se~ nl ~1~3~52 54 withdraws from the second (large) c~ ..be 60, a partial vacuum will be created in the second ~arge) cl~s--~ 60, causing diluent 68 to flow from the source of diluent 88 through the tubing 89 and the third valve conduit 82, l}llough the cnnnP~1;nn A in the valve 70, through the second valve conduit 76, tubing 80, and the third port 64 and into the second (large) ~ 5~her 60, as indi(-~q-t~d by the curved arrows. As shown in FIG. 7, the valve 70 then breaks col~n~!;on A and establishes a co~ ~t;nn C bet~the second valve conduit 76 and the first valve conduit 72. The smaller ~1i5~
~ t 54 is then a l~d into the second (large) chqmh~r 60 by the motor 42 in the direction shown by the arrow D. The piston thus forces air and diluent out of the second (large) cllq-mh~r 60, through tubing 80 and the second valve conduit 76, through conn~;nn C in the valve 70, the first valve conduit 72, tubing 74, and second pump port 36 and into the first (small) cl~5..~b~ 58. l~a ~e the second ~ p~ d volumeof Qarge) ~1.5....h~. 60 is much larger than the residual volume in the first (sm~all) ~h~...b-,~ 58, . ir and diluent will be forced out of the first (small) ch5~b~, 58 ~ u~;h the first port 34 and tubing 91 and pipette 92 and into the waste r~e~t~^le 93. The pump, v lve, and all c4n~1;ng ~.lions will now contain only diluent, with no trapped air. This cycle may be l~e~d to ~1i....nale air co r~e~ly.
FIG. 8 shows the op~ n of the pump in ~ I;n~ a small qu&~ of sample. The valve 70 will e~t~qh1i~h c~nl e~;-~n A bel~n the third valve conduit 82 and the third port 64. The motor 42 will withdraw the larger ~ t~ s~.l;.. - nl 52 from the from the first (small) cl~..ker 58, in the direction show by the . rrow B. As the larger ~li5"~i-1t;r ~æ~ nl 52 withdraws, a small volume of sample 66 equal to (IIrl2-IIr22)x as ii~u~sed above will be drawn into the first (small) ch~...b-~r 58 ll~ gh the pipette 92, tubing 91, and first port 34 from the sample source 90. CQnCU~ Y~ a volume of diluent 68 will be drawn into the second (large) e1l5~, b~r 60. All or part of the sample in the first (small) ~ n~ke~ 58 may now be ~ n~ed through the first port 34 by ad~lcing the piston 38 a known ~ict~nr~, with the sample source 90 being 9 ~ 3 9 5 2 PCT/US95/05199 -replaced by a ,~c~p~ e 93. At the same time, diluent will be l~lul~lcd from the second (large) chs-.-hP~ 60 lhr~ugh co~n~~ n A to the source of diluent 88.
FIG. 9 shows the op~ .~t;on of the pump in ~ g a large ~luarllily of diluent.
The valve 70 will est~hli~h conl-Pcl;ol- C bet~cen the first valve conduit 72 and the second valve conduit 76. As the piston 38 is wi~d~wn from the first (small) cl ~...he-58 and second ~arge) c~ ~t 60 by the motor 42 in the d~li~n of the arrow B, a volume of diluent 68 from the source of diluent 88 will be drawn lll~uuE,h the pipette 92, tubing 91, first port 34, second port 36, tubing 74, first valve conduit 72, T-c4nnP,~lor 84, second valve conduit 76, tubing 80, and third port 64 into the first (small) ch~...be~ 58 and second (large) ch~mhe~ 60. The ..~ i...u... volume ~
will equal the sum of the volumes ~ d in the first (small) cl-~."~ 58 and the second (large) cl~ bc~ 60, that is (IIrl2- IIr22)x + IIr22x=IIrl2. The diluent may now be ~ ~n~A by advancing the piston 38, with the source of diluent 88 being l~plac~d with a ,~cep~cl~ 93 for receiving the diluent.
It will be seen that a multi-mode fluid ~ n~ pump with a single piston has been ~esc~il)ed Several P~ -hot1;...Pnt~ have ~IP~ ibed In a first ~ .~bo~ nt~ the single piston is of the same ~ uuglloul its length, lccip~ ing in a single ch "~bPI . In the second c -bo~ t, the piston is tapered so as to compric~P a rod with ~.~ ,,.,~.,lc of two di~f~.~nl ~ t~-~ This produces a pump with a fluid ~ p~
equal to the dirr~.~nce in volumes of the s~ In a third e~.~bo~ ,nt, a second e~ be~ is added, so as to provide two dirr~ t ~ plr~cn~c with the same pump.
In all e "bo~l;- --- .l~, the piston is p~f~l~ly driven by a stepper motor and lead screw ge ~ which is axially aligned with the piston and C~ ber. The pump has the a~lva~ge of being able to very a~u-dt~ly ~i~Pn~P, either very small volumes of sample or larger volumes of diluent, or both at the same time. A further advantage is that the p~eci~ion driving ...~1~An;~m is axially aligned with the piston and r.hA".hf and the two seals which assist in ~lignmP-nt and lG~luoed wear, thereby p~lucil~g less stnun 21 ~895~
BRIEF DESCRIPIION OF THE DRAWINGS
FIG. 1 is a ~-~lK~1;ve view of the fluid ~isr1~^pm~nt pump.
FIG. 2 is a partially broken away scl.e ..AI;c of one prefcll~ e ..bo~ nt of thefluid ~;s~ .".~nl pump.
FIG. 3 is a par~ally broken away sclu .AI;c of a second plefcll~d e-..~;. .v--t of the fluid ~ 1J1~ ...f nl pump.
FIG. 4 is a pa~ally broken away s hf,..~l;r of a third plcfc.l~d c,,lbodi,~ t of the fluid ~ f...- nl pump.
FIG. S is a par~ally broken away s~ l;r of the fluid ~ f -.. .-t pump in a complete system for ~ n~ ~ the sample and diluent.
FIG. 6 shows the sC~ ;r ~!pe~1ir~n of the pump in ~ e diluent to pdme the pump.
FIG. 7 shows the K~ ;c opf-~.l;n~ of the pump in completing the p-;.--;.
cycle.
r FIG. 8 shows the s~ opP~tion of the pump in ~ At;~e a small ~ y of sample.
'`3 5~ -FIG. 9 shows the ~I~ ;c ope,~lion of the pump in ~c~ l;ng a large ~lua~ y of diluent.
DETAILED DESCRIPIION OF THE ~REFERRED EMBODIM~ITS
The mllltim~e fluid .lispl~ pump is shown genPr~lly as nu~bel 10 in the Figures. FIG. 2 shows a first embo limPnt 12 of the pump 10, which is used for ;ng and li~ -cin~ large volumes of fluid. The pump 10 has a hol-cing 14, which comrricp~s a top wall 16, bottom wall 18 and side wall 20. The top wall 16, bottom wall 18, and side wall 20 enclose an interior 22. The inner surface 24 of the side wall 20 has an annular means or groove 26 in which a seal 28 is ....Ju~-led The seal 28, the inner surface 24 of the side wall 20, and the inner surface 30 of the bottom wall 18 form a C1~5~'her 32. The c~ k~ ~ 32 has a first port 34 and a second port 36 for q~;.i.l;,~g and ~ ;.-g fluids. Mounted l~iplocally within the rhs~lser 32 and sliding through the seal 28 is a piston 38.
The piston 38 is driven and accurately positinn~ lnngitl]-lin~lly within the ch~ 32 by a pos l;on;~g means 40. In the p~f~ d e-..bo~ , the positin means 40 col~ ;~s linear ~st~ q~ol or a stepper motor 42 and a lead screw 44, the lead screw being connr~led to the piston 38. In the plc;~ d embo~imPnt, the positinn means 40 is s ~ ;qlly a~ially aligned with the C]~51~1b... 32 and piston 38.
In oper~tinn of the first e ~l~o~ 12, fluid is ~s~ d into the ~ 5~bC 32 by ~c~ g the motor 42 and lead screw 44 to will~w the piston 38 from the cl~...be 32. This ",o~e.l.~n~ creates a partial v~Cuulll in the ch~mbPr 32, allowing fluid to flow into the c~ - be~ 32 through the first port 34. The amount of fluid d is equal to IIr,2x, where r, is the radius of the piston 38 and x is the fli by which the piston is withdrawn. The lict~nce x can be controlled very ~u~t 1~by the stepper motor and lead screw. Fluid is dicpenc~P~ by a~lv~ncing the piston 38 PCT/US95/0~19 2 ~ ~ g 5 2 lP~J~iS 2 6 AP R 1~96 into the challlber 32, forcing fluid out of the pump through the second port 36. The operation ofthe first port 34 and second port 36 is controlled by a valve (not shown) which permits fluid to enter through the first port 34 and exist through the second port 36. The pump is first primed with fluid, by aspirating and dispensing fluid as described above, to remove all air before operation begins.
FIG. 3 shows a second embodiment 46 of the pump 10, used for aspirating and dispensing small volumes of fluid, wherein the chamber 32 is defined by seal 28 in annular groove 26 at the end of the chamber 32 nearest the positioning means 40, and second seal 47 in a second annular groove 48 in the inner surface 24 of the side wall 20 at the end ofthe chamber 32 nearest the bottom wall 18. The piston 38 further comprises a rod 38 with a step 50, thereby forming a larger diameter segment 52 and a smaller diameter segment 54. The step 50 may be machined so as to create a range of differences in diameter between the larger diameter segment 52 and smaller diameter segment 54, thereby creating a range of fluid displ~cçm.onts. Preferably, the chamber 32 is made narrower at some point along its length so as to accommodate and firmly grip the smaller diameter segment 54 by the second seal 47. Alternatively, the outer diameter of seal 47 may be larger than seal 28 rather than ch~nging chamber dimensions. The chamber 32 has a first port 34 and a second port 36 for a~pilalillg and dispensing fluids.
The piston 38 is driven and accurately positioned longit~l-lin~lly within the chamber 32 by a positioning means 40. In the prefelled embodiment, the positioning means 40 comprises a stepper motor 42 and a lead screw 44, the lead screw being connected to the piston 38. In the preferred embodiment, the positioning means 40 is substantially axially aligned with the chamber 32 and piston 38.
In operation of the second embodiment 46, fluid is aspirated into the chamber 32 by actl1ating the motor 42 and lead screw 44 to withdraw the larger diameter /~ME~IDED ~H~ET
WO 95130089 PCTtUS95tO5199 ...c~nt 52 from the c~ 32. This movement creates a partial vacuum in the c~ b~ 32, allowing fluid to flow into the ch~---hc~ 32 through the first port 34. The amount of fluid ~c~ ~ is equal to (IIrl2- IIr22)x, where r~ is the radius of the larga 1;a.~.fta s~ e-~t r2 is the radius of the smaller .1;5,.~ trr ~~ n~, and % is the ~lict~n~e by which the larger 1;s---~t~r is wi~ldlawn. The ~lict~nr~ X can be controlled very ~ tf-ly by the st~pper motor and lead screw. Fluid is ~ by ad~dr,cing the larger .1i~.f ~ se~...e~-l into the c1.s.~ h~r 32, forcing fluid out of the pump through the second port 36. The operation of the first port 34 and second port 36 is controlled by a valve (not shown) which permits fluid to enter through the first port 34 and exit through the second port 36. The pump is first primed with fluid, by ~ t;ng and ~;~ n~ g fluid as 1pc-crihe~ above, to remove all air before opp~ration begins.
FIG. 4 shows a third ~-.-ho~l;..- ~1 56 of the pump 10, used for Aic~ g both hrge and small qu~ s of fluid, ~h~ there is a first (small) cha~llh r 58 in which the larger di5~f t~ le-ll 52 and the smaller ~1i5.,.. t- r se 111~ nt 54 l~Cipl'~dll~
~e~1~r~ and a second ~arge) chb ..hPr 60 in which the smaller dis ~?t ~ ..t 54 l~Cipl~idLC!i. The first (small) cl~-.h~r 58 is sep~dt~d from the second ~arge) 60 by the seal 61 in an annuhr groove 62 in the inna surface 24 of the side wall 20 and by the smaller di5-"~ tt.,~' S~ 54. The first (small) ~h~ ber 58 has a first port 34 and a second port 36 for ~ g and tli~p~ n~ g fluids. The second (large) chsr~ber 60 has a third port 64 for ~l';'; I;ng and ~i~en~ing fluids. It will be seen that the larger ~;~ -elP~ s~GI~f n~ 52 and smaller fli~"-~ t~ -.l 54 define a first fluid fl~a~ volume in the first (small) C]l'll'bf,- 58 equal to the dirr~n~
~t~n the volume of the larger ~ ll'f h l S~-'f -t 52 and the volume of the smaller 1~;5~ ,r ~c...~.nl 54. The smaller fl;~ - Sf~r.l~ent 54 defines a second fluid p~ mfnt volume in the second ~arge) ch-b-~..b- 60 equal to the volume of the smaller ~ t~;r sf~ -nt 54.
W O 95130089 PC~rrUS95/05199 ~1~8952 -FIG. 5 shows the fluid dis~1a~.~ "enl pump 10 in a co,l,l)lele system for g and ~ g the sample 66 and diluent 68. The flow of fluids thl~u h the 'first port 34, second port 36, and third port 64 is controlled by a valve 70. The valve 70 has a first valve conduit 72 c4~-nr~l~ to the second port 36 of the pump 10 by tubing 74, and a second valve conduit 76 conn?~led to the third port 64 of the pump 10 by tubing 80. The valve 70 also has a third valve conduit 82 connP~d to a source of diluent 88 by tubing 89. The valve 70 also has a rotating T-col-n~or 84 with arms 86 for int~.-~-F~ g the various valve con-l.-;lc. A source of sample 90 is connec'~d to the first port 34 of the pump 10 by tubing 91 and pipette 92, as the pipette 92 dips into the sample 66.
The opP~tinn of the third e."bo l;...- n~ will now be d~ ;bed. It will be seen that two ~r~..t ~l;c~ e~ volu~es are available from the pump 10. As larger ~1;Z~ h, S~,~;Jn~nl 52 is ~~ c~d by the pos;linning means 40 into the first (small) c)~a---lD&r 58, a volume of fluid will be ~icpl~ CÇd equal to (IIr,2- IIr22)x, where r, is the radius of the hrger ~ ,... h' ~ nl, r2 iS the radius of the smaller f~ia.... hr.r ~.~ .,nl, and x is the ~ic~nee by which the larger ~iz...- h~,- se~ nl 52 is advanced. The~i;c~n-~ x may be controlled very ~,~u~ ely by the stepper motor 42 and lead screw 44, or other equivalent po~:l;9n;~g means 40. As the smaller ~;z ..~ set--.f-n~ 54 is a~lv~nced by the positinning means 40 into the second ~arge) c . b~ ~ 60, the smaller ~l;z".~t~r S~'L"'-`~ 54 will displace a volume of fluid egual to IIr22x, where r2 is the radius of the smaller 'l;h'~ s~ l and x is the ~ist~nee by which the s, ~ is a~-vanccd.
The pump 10 is initially primed as follows, as shown in FIG. 6 and FIG. 7.
The valve 70 will make a c4nnr~1;nn A b. h~n the third valve conduit 82 and the second valve conduit 76 by ~s;l;o~ing the T-col-nrc.l~r 84 as shown. The smaller~1;z...l ~nr s~ - -t 54 will be withdrawn from the second (large) cl-~-..b~l 60 by the motor 42 in the d-.eclion as shown by the arrow B. As the smaller ~i~...P~. r se~ nl ~1~3~52 54 withdraws from the second (large) c~ ..be 60, a partial vacuum will be created in the second ~arge) cl~s--~ 60, causing diluent 68 to flow from the source of diluent 88 through the tubing 89 and the third valve conduit 82, l}llough the cnnnP~1;nn A in the valve 70, through the second valve conduit 76, tubing 80, and the third port 64 and into the second (large) ~ 5~her 60, as indi(-~q-t~d by the curved arrows. As shown in FIG. 7, the valve 70 then breaks col~n~!;on A and establishes a co~ ~t;nn C bet~the second valve conduit 76 and the first valve conduit 72. The smaller ~1i5~
~ t 54 is then a l~d into the second (large) chqmh~r 60 by the motor 42 in the direction shown by the arrow D. The piston thus forces air and diluent out of the second (large) cllq-mh~r 60, through tubing 80 and the second valve conduit 76, through conn~;nn C in the valve 70, the first valve conduit 72, tubing 74, and second pump port 36 and into the first (small) cl~5..~b~ 58. l~a ~e the second ~ p~ d volumeof Qarge) ~1.5....h~. 60 is much larger than the residual volume in the first (sm~all) ~h~...b-,~ 58, . ir and diluent will be forced out of the first (small) ch5~b~, 58 ~ u~;h the first port 34 and tubing 91 and pipette 92 and into the waste r~e~t~^le 93. The pump, v lve, and all c4n~1;ng ~.lions will now contain only diluent, with no trapped air. This cycle may be l~e~d to ~1i....nale air co r~e~ly.
FIG. 8 shows the op~ n of the pump in ~ I;n~ a small qu&~ of sample. The valve 70 will e~t~qh1i~h c~nl e~;-~n A bel~n the third valve conduit 82 and the third port 64. The motor 42 will withdraw the larger ~ t~ s~.l;.. - nl 52 from the from the first (small) cl~..ker 58, in the direction show by the . rrow B. As the larger ~li5"~i-1t;r ~æ~ nl 52 withdraws, a small volume of sample 66 equal to (IIrl2-IIr22)x as ii~u~sed above will be drawn into the first (small) ch~...b-~r 58 ll~ gh the pipette 92, tubing 91, and first port 34 from the sample source 90. CQnCU~ Y~ a volume of diluent 68 will be drawn into the second (large) e1l5~, b~r 60. All or part of the sample in the first (small) ~ n~ke~ 58 may now be ~ n~ed through the first port 34 by ad~lcing the piston 38 a known ~ict~nr~, with the sample source 90 being 9 ~ 3 9 5 2 PCT/US95/05199 -replaced by a ,~c~p~ e 93. At the same time, diluent will be l~lul~lcd from the second (large) chs-.-hP~ 60 lhr~ugh co~n~~ n A to the source of diluent 88.
FIG. 9 shows the op~ .~t;on of the pump in ~ g a large ~luarllily of diluent.
The valve 70 will est~hli~h conl-Pcl;ol- C bet~cen the first valve conduit 72 and the second valve conduit 76. As the piston 38 is wi~d~wn from the first (small) cl ~...he-58 and second ~arge) c~ ~t 60 by the motor 42 in the d~li~n of the arrow B, a volume of diluent 68 from the source of diluent 88 will be drawn lll~uuE,h the pipette 92, tubing 91, first port 34, second port 36, tubing 74, first valve conduit 72, T-c4nnP,~lor 84, second valve conduit 76, tubing 80, and third port 64 into the first (small) ch~...be~ 58 and second (large) ch~mhe~ 60. The ..~ i...u... volume ~
will equal the sum of the volumes ~ d in the first (small) cl-~."~ 58 and the second (large) cl~ bc~ 60, that is (IIrl2- IIr22)x + IIr22x=IIrl2. The diluent may now be ~ ~n~A by advancing the piston 38, with the source of diluent 88 being l~plac~d with a ,~cep~cl~ 93 for receiving the diluent.
It will be seen that a multi-mode fluid ~ n~ pump with a single piston has been ~esc~il)ed Several P~ -hot1;...Pnt~ have ~IP~ ibed In a first ~ .~bo~ nt~ the single piston is of the same ~ uuglloul its length, lccip~ ing in a single ch "~bPI . In the second c -bo~ t, the piston is tapered so as to compric~P a rod with ~.~ ,,.,~.,lc of two di~f~.~nl ~ t~-~ This produces a pump with a fluid ~ p~
equal to the dirr~.~nce in volumes of the s~ In a third e~.~bo~ ,nt, a second e~ be~ is added, so as to provide two dirr~ t ~ plr~cn~c with the same pump.
In all e "bo~l;- --- .l~, the piston is p~f~l~ly driven by a stepper motor and lead screw ge ~ which is axially aligned with the piston and C~ ber. The pump has the a~lva~ge of being able to very a~u-dt~ly ~i~Pn~P, either very small volumes of sample or larger volumes of diluent, or both at the same time. A further advantage is that the p~eci~ion driving ...~1~An;~m is axially aligned with the piston and r.hA".hf and the two seals which assist in ~lignmP-nt and lG~luoed wear, thereby p~lucil~g less stnun 21 ~895~
and wear on the seals and oc.;~i- g less space. Furthermore, the stepper motor and lead screw ~rr~ng e"-~ has less slack or play in it than a pulley and drive belt The present invention may be embodied in other s~ific forms without dcp~ g from the spirit or e~Pnti~l attributes thereof, and it is thc~ro~ desired that the present embo~1imPnt be c~nQi~P~ed in all l~cls as illl str~tive and not restrictive, f~nce being made to the ~ ded claims rather than to the fcn~ going des~ JI;o~
to inrlir~te the scope of the invention.
to inrlir~te the scope of the invention.
Claims
1. A fluid displacement pump, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) means in the inner surface of the side wall for carrying a seal therein, (c) an elongated chamber, formed by the inner surface of the bottom wall, inner surface of the side wall, and the seal, having a piston reciprocally mounted therein, the piston sliding through the seal, (d) means for accurately positioning the piston within the chamber so as to measure a fluid displacement, wherein the positioning means further comprises a stepper motor and a lead screw, and (e) two ports for aspirating and dispensing fluid from the chamber wherein the positioning means is substantially axially aligned with the piston and chamber.
3. The pump as in claim 1, wherein the piston comprises a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said chamber.
4. The pump as in claim 3, wherein the chamber is sealed by seals through which one of the segments slides.
5. The pump as in claim 3, wherein the chamber is narrowed so as to accommodate and firmly grip the smaller diameter segment.
6. The pump as in claim 3, wherein the positioning means is substantially axially aligned with the piston and chamber.
7. The pump as in claim 6, wherein the positioning means further comprises a stepper motor and a lead screw.
8. The pump as in claim 3, wherein the elongated chamber further comprises a first chamber and a second chamber, separated from each other by a seal through which one of the segments slides, and wherein said first fluid displacement is defined in the first chamber and a second fluid displacement is defined in the second chamber equal to the volume of one of the segments, the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
9. The pump as in claim 8, wherein the positioning means is substantially axially aligned with the chamber and piston.
10. The pump as in claim 9, wherein the positioning means further comprises a stepper motor and a lead screw.
11. The pump as in claim 8, wherein the chamber is narrowed so as to accommodate and firmly grip the smaller diameter segment.
12. A fluid displacement pump, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) an elongated chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a fluid displacement equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said chamber, the smaller diameter segment sliding through the second seal, (f) means for accurately positioning the piston within the chamber so as to measure the fluid displacement, and (g) two ports for aspirating and dispensing fluid from the chamber.
13. The pump as in claim 12, wherein the positioning means is substantially axially aligned with the piston and chamber.
14. The pump as in claim 13, wherein the positioning means further comprises a stepper motor and a lead screw.
15. A fluid displacement pump, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) a first chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement in the first chamber equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said first chamber, (f) a second chamber, sealed from the first chamber, formed by the inner surface of the side wall, the inner surface of the bottom wall, and the second seal, and wherein a second fluid displacement is defined in the second chamber equal to the volume of the smaller diameter segment, and wherein the smaller diameter segment slides through the second seal, and (g) means for accurately positioning the piston within the chamber so as to measure the fluid displacements, and (h) three ports for aspirating and dispensing fluid from the first chamber and second chamber, the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
16. The pump as in claim 15, wherein the positioning means is substantially axially aligned with the piston and chamber.
17. The pump as in claim 16, wherein the positioning means further comprises a stepper motor and a lead screw.
18. A fluid displacement pump for selectively dispensing precise quantities of two fluids, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) a first chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement in the first chamber equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said first chamber, (f) a second chamber, sealed from the first chamber, formed by the inner surface of the side wall, the inner surface of the bottom wall, and the second seal, and wherein a second fluid displacement is defined in the second chamber equal to the volume of the smaller diameter segment, and wherein the smaller diameter segment slides through the second seal, (g) means for accurately positioning the piston within the chamber so as to measure the fluid displacements, (h) three ports for aspirating and dispensing the fluids from the first chamber and second chamber, and (i) valve means for controlling the pump to allow the first chamber to dispense one fluid and the second chamber to dispense a different fluid; the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
19. The pump as in claim 18, wherein the positioning means is substantially axially aligned with the piston and chamber.
20. The pump as in claim 19, wherein the positioning means further comprises a stepper motor and a lead screw.
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) means in the inner surface of the side wall for carrying a seal therein, (c) an elongated chamber, formed by the inner surface of the bottom wall, inner surface of the side wall, and the seal, having a piston reciprocally mounted therein, the piston sliding through the seal, (d) means for accurately positioning the piston within the chamber so as to measure a fluid displacement, wherein the positioning means further comprises a stepper motor and a lead screw, and (e) two ports for aspirating and dispensing fluid from the chamber wherein the positioning means is substantially axially aligned with the piston and chamber.
3. The pump as in claim 1, wherein the piston comprises a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said chamber.
4. The pump as in claim 3, wherein the chamber is sealed by seals through which one of the segments slides.
5. The pump as in claim 3, wherein the chamber is narrowed so as to accommodate and firmly grip the smaller diameter segment.
6. The pump as in claim 3, wherein the positioning means is substantially axially aligned with the piston and chamber.
7. The pump as in claim 6, wherein the positioning means further comprises a stepper motor and a lead screw.
8. The pump as in claim 3, wherein the elongated chamber further comprises a first chamber and a second chamber, separated from each other by a seal through which one of the segments slides, and wherein said first fluid displacement is defined in the first chamber and a second fluid displacement is defined in the second chamber equal to the volume of one of the segments, the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
9. The pump as in claim 8, wherein the positioning means is substantially axially aligned with the chamber and piston.
10. The pump as in claim 9, wherein the positioning means further comprises a stepper motor and a lead screw.
11. The pump as in claim 8, wherein the chamber is narrowed so as to accommodate and firmly grip the smaller diameter segment.
12. A fluid displacement pump, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) an elongated chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a fluid displacement equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said chamber, the smaller diameter segment sliding through the second seal, (f) means for accurately positioning the piston within the chamber so as to measure the fluid displacement, and (g) two ports for aspirating and dispensing fluid from the chamber.
13. The pump as in claim 12, wherein the positioning means is substantially axially aligned with the piston and chamber.
14. The pump as in claim 13, wherein the positioning means further comprises a stepper motor and a lead screw.
15. A fluid displacement pump, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) a first chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement in the first chamber equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said first chamber, (f) a second chamber, sealed from the first chamber, formed by the inner surface of the side wall, the inner surface of the bottom wall, and the second seal, and wherein a second fluid displacement is defined in the second chamber equal to the volume of the smaller diameter segment, and wherein the smaller diameter segment slides through the second seal, and (g) means for accurately positioning the piston within the chamber so as to measure the fluid displacements, and (h) three ports for aspirating and dispensing fluid from the first chamber and second chamber, the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
16. The pump as in claim 15, wherein the positioning means is substantially axially aligned with the piston and chamber.
17. The pump as in claim 16, wherein the positioning means further comprises a stepper motor and a lead screw.
18. A fluid displacement pump for selectively dispensing precise quantities of two fluids, comprising:
(a) a housing, having a top wall, bottom wall, and side wall, the bottom wall and side wall each having an inner surface, the top wall, bottom wall, and side wall enclosing an interior therebetween, (b) a first means in the inner surface of the side wall for carrying a first seal therein, (c) a second means in the inner surface of the side wall for carrying a second seal therein, (d) a first chamber, formed by the inner surface of the side wall, the first seal, and the second seal, having a piston reciprocally mounted therein, (e) the piston further comprising a single stepped rod with a larger diameter segment and a smaller diameter segment, and wherein the piston defines a first fluid displacement in the first chamber equal to the diameter of the larger diameter segment minus the diameter of the smaller diameter segment times the length of piston inserted into said first chamber, (f) a second chamber, sealed from the first chamber, formed by the inner surface of the side wall, the inner surface of the bottom wall, and the second seal, and wherein a second fluid displacement is defined in the second chamber equal to the volume of the smaller diameter segment, and wherein the smaller diameter segment slides through the second seal, (g) means for accurately positioning the piston within the chamber so as to measure the fluid displacements, (h) three ports for aspirating and dispensing the fluids from the first chamber and second chamber, and (i) valve means for controlling the pump to allow the first chamber to dispense one fluid and the second chamber to dispense a different fluid; the pump being capable of aspirating or dispensing either the first fluid displacement or the second fluid displacement or both fluid displacements in a single stroke.
19. The pump as in claim 18, wherein the positioning means is substantially axially aligned with the piston and chamber.
20. The pump as in claim 19, wherein the positioning means further comprises a stepper motor and a lead screw.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/234,282 | 1994-04-28 | ||
| US08/234,282 US5540562A (en) | 1994-04-28 | 1994-04-28 | Single-piston, multi-mode fluid displacement pump |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2188952A1 true CA2188952A1 (en) | 1995-11-09 |
Family
ID=22880718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002188952A Abandoned CA2188952A1 (en) | 1994-04-28 | 1995-04-27 | Single-piston, multi-mode fluid displacement pump |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5540562A (en) |
| EP (1) | EP0757757B1 (en) |
| JP (1) | JPH09512614A (en) |
| CA (1) | CA2188952A1 (en) |
| DE (1) | DE69514098T2 (en) |
| WO (1) | WO1995030089A1 (en) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6007310A (en) * | 1993-11-23 | 1999-12-28 | Sarcos, Lc | Volumetric pump with sterility seal |
| US6409722B1 (en) * | 1998-07-07 | 2002-06-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
| US6234771B1 (en) | 1998-06-02 | 2001-05-22 | Bayer Corporation | Precision pumping device |
| US7811282B2 (en) | 2000-03-06 | 2010-10-12 | Salient Surgical Technologies, Inc. | Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof |
| US8048070B2 (en) | 2000-03-06 | 2011-11-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices, systems and methods |
| US6689131B2 (en) | 2001-03-08 | 2004-02-10 | Tissuelink Medical, Inc. | Electrosurgical device having a tissue reduction sensor |
| US6558385B1 (en) | 2000-09-22 | 2003-05-06 | Tissuelink Medical, Inc. | Fluid-assisted medical device |
| EP1946716B1 (en) * | 2000-03-06 | 2017-07-19 | Salient Surgical Technologies, Inc. | Fluid delivery system and controller for electrosurgical devices |
| DE10129665A1 (en) * | 2001-06-20 | 2003-01-09 | Mueller A & K Gmbh Co Kg | Device for dispensing cold or hot water in measured portions, in particular for the production of beverages |
| EP1435867B1 (en) * | 2001-09-05 | 2010-11-17 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices and systems |
| US6884231B1 (en) | 2002-10-17 | 2005-04-26 | Hamilton Company | Dual chambered fluid displacement apparatus |
| US8475455B2 (en) | 2002-10-29 | 2013-07-02 | Medtronic Advanced Energy Llc | Fluid-assisted electrosurgical scissors and methods |
| US7543720B2 (en) * | 2003-05-05 | 2009-06-09 | The Lee Company | Method and apparatus for dispensing small volumes of fluid |
| GB0321576D0 (en) * | 2003-09-15 | 2003-10-15 | Boc Group Plc | Valving for multi-stage vacuum pumps |
| US20050158191A1 (en) * | 2004-01-21 | 2005-07-21 | Innovative Mechanical Designs, Inc. | Highly accurate pumping device |
| US7727232B1 (en) | 2004-02-04 | 2010-06-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices and methods |
| JP4040049B2 (en) * | 2005-03-18 | 2008-01-30 | 横浜ゴム株式会社 | Shot pump and variable speed two-component metering and mixing device |
| FR2895920B1 (en) * | 2006-01-06 | 2008-04-18 | Gilson Sas Soc Par Actions Sim | MULTIVOLUM PIPETTE. |
| US20080187449A1 (en) * | 2007-02-02 | 2008-08-07 | Tetra Laval Holdings & Finance Sa | Pump system with integrated piston-valve actuation |
| WO2009086448A1 (en) | 2007-12-28 | 2009-07-09 | Salient Surgical Technologies, Inc. | Fluid-assisted electrosurgical devices, methods and systems |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| EP2334234A4 (en) | 2008-09-19 | 2013-03-20 | Tandem Diabetes Care Inc | Solute concentration measurement device and related methods |
| US9254168B2 (en) | 2009-02-02 | 2016-02-09 | Medtronic Advanced Energy Llc | Electro-thermotherapy of tissue using penetrating microelectrode array |
| JP5592409B2 (en) | 2009-02-23 | 2014-09-17 | サリエント・サージカル・テクノロジーズ・インコーポレーテッド | Fluid-assisted electrosurgical device and method of use thereof |
| WO2011014704A2 (en) | 2009-07-30 | 2011-02-03 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| JP2013503723A (en) | 2009-09-08 | 2013-02-04 | サリエント・サージカル・テクノロジーズ・インコーポレーテッド | Cartridge assembly for electrosurgical devices, electrosurgical units, and methods of use thereof |
| WO2011112991A1 (en) | 2010-03-11 | 2011-09-15 | Salient Surgical Technologies, Inc. | Bipolar electrosurgical cutter with position insensitive return electrode contact |
| US20110295249A1 (en) * | 2010-05-28 | 2011-12-01 | Salient Surgical Technologies, Inc. | Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof |
| US9138289B2 (en) | 2010-06-28 | 2015-09-22 | Medtronic Advanced Energy Llc | Electrode sheath for electrosurgical device |
| US8906012B2 (en) | 2010-06-30 | 2014-12-09 | Medtronic Advanced Energy Llc | Electrosurgical devices with wire electrode |
| US9750565B2 (en) | 2011-09-30 | 2017-09-05 | Medtronic Advanced Energy Llc | Electrosurgical balloons |
| US8870864B2 (en) | 2011-10-28 | 2014-10-28 | Medtronic Advanced Energy Llc | Single instrument electrosurgery apparatus and its method of use |
| US20150086386A1 (en) * | 2012-04-23 | 2015-03-26 | Siemens Healthcare Diagnostics Inc. | Multi-chamber pump apparatus, systems, and methods |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9226792B2 (en) | 2012-06-12 | 2016-01-05 | Medtronic Advanced Energy Llc | Debridement device and method |
| US11234760B2 (en) | 2012-10-05 | 2022-02-01 | Medtronic Advanced Energy Llc | Electrosurgical device for cutting and removing tissue |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| US10314647B2 (en) | 2013-12-23 | 2019-06-11 | Medtronic Advanced Energy Llc | Electrosurgical cutting instrument |
| US10813686B2 (en) | 2014-02-26 | 2020-10-27 | Medtronic Advanced Energy Llc | Electrosurgical cutting instrument |
| US9974599B2 (en) | 2014-08-15 | 2018-05-22 | Medtronic Ps Medical, Inc. | Multipurpose electrosurgical device |
| BR112017013218B1 (en) * | 2014-12-19 | 2023-04-18 | Zhengzhou Sanhua Technology & Industry Co., Ltd | CONTROL VALVE TO DELIVER COLOR PASTE |
| US10376302B2 (en) | 2015-02-18 | 2019-08-13 | Medtronic Xomed, Inc. | Rotating electrical connector for RF energy enabled tissue debridement device |
| US11207130B2 (en) | 2015-02-18 | 2021-12-28 | Medtronic Xomed, Inc. | RF energy enabled tissue debridement device |
| US10188456B2 (en) | 2015-02-18 | 2019-01-29 | Medtronic Xomed, Inc. | Electrode assembly for RF energy enabled tissue debridement device |
| US11389227B2 (en) | 2015-08-20 | 2022-07-19 | Medtronic Advanced Energy Llc | Electrosurgical device with multivariate control |
| US11051875B2 (en) | 2015-08-24 | 2021-07-06 | Medtronic Advanced Energy Llc | Multipurpose electrosurgical device |
| US10716612B2 (en) | 2015-12-18 | 2020-07-21 | Medtronic Advanced Energy Llc | Electrosurgical device with multiple monopolar electrode assembly |
| JP7141207B2 (en) * | 2017-11-21 | 2022-09-22 | キヤノンメディカルシステムズ株式会社 | Dispensing syringe pump and automatic analyzer equipped with the same |
| WO2020033598A1 (en) * | 2018-08-07 | 2020-02-13 | Shouyan Lee | Hybrid heart valve function tester specifically designed for production evaluation of prosthetic heart valve products |
| CN112672799B (en) * | 2018-09-25 | 2023-04-04 | 安捷伦科技有限公司 | Two-dimensional fluid separation with push-pull modulation |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US225175A (en) * | 1880-03-02 | Apparatus for drawing liquids from casks | ||
| US1393085A (en) * | 1921-01-06 | 1921-10-11 | Ingersoll Rand Co | Compressor |
| US1695305A (en) * | 1926-10-20 | 1928-12-18 | French Oil Mill Machinery | Ram |
| US2032163A (en) * | 1932-09-30 | 1936-02-25 | Ralph B Bagby | Filling machine |
| US1966498A (en) * | 1933-05-04 | 1934-07-17 | Gross Louis | Fluid measuring and dispensing apparatus |
| US2396602A (en) * | 1938-08-13 | 1946-03-12 | Posch Oskar | Liquid pump |
| US2383324A (en) * | 1942-08-24 | 1945-08-21 | Clair Camille Clare Sprankl Le | Reciprocating pump |
| GB556538A (en) * | 1942-09-25 | 1943-10-08 | Cecil Cyprian Higgens | Improvements in or relating to differential pistons |
| US2508253A (en) * | 1946-09-26 | 1950-05-16 | Dean C Haggardt | Compressor unit |
| US2889108A (en) * | 1955-02-16 | 1959-06-02 | Ingersoll Rand Co | Compressor |
| US3036529A (en) * | 1960-04-07 | 1962-05-29 | Farley J Archer | Pump |
| US3168045A (en) * | 1961-09-13 | 1965-02-02 | Sebastiani Martin | Pump for thick materials |
| US3155041A (en) * | 1963-05-16 | 1964-11-03 | Mansfield Green Inc | Pressure apparatus |
| US3227325A (en) * | 1963-06-26 | 1966-01-04 | Leonard E Bates | Metering dispenser for plastic materials |
| US3333548A (en) * | 1965-06-21 | 1967-08-01 | Prec Scient Company | Positive displacement pump |
| US3471079A (en) * | 1967-09-21 | 1969-10-07 | Elman B Myers | Reciprocating vacuum pump |
| US3695788A (en) * | 1970-01-09 | 1972-10-03 | Bernard A Loomans | Apparatus for pumping fluids |
| US3802805A (en) * | 1970-06-24 | 1974-04-09 | Otto Engineering | Pumping apparatus |
| US3704080A (en) * | 1970-07-22 | 1972-11-28 | Grosvenor M Cross | Fluid engine |
| GB1379023A (en) * | 1971-01-12 | 1975-01-02 | Dilger L | Fluid metering system |
| US4090818A (en) * | 1976-05-25 | 1978-05-23 | Hope Henry F | Adjustable metering pump |
| DK318878A (en) * | 1977-07-20 | 1979-01-21 | J R Meilstrup | PISTON COMPRESSOR NAMELY HIGH PRESSURE AIR COMPRESSOR FOR CHARGING RESPIRATORY AIR BOTTLES FOR DIVERS |
| DK136378A (en) * | 1978-03-28 | 1979-09-29 | Foss A S | DOSAGE PUMPS |
| US4255096A (en) * | 1979-01-08 | 1981-03-10 | Baxter Travenol Laboratories, Inc. | Drive for syringe pump |
| US4657488A (en) * | 1979-12-14 | 1987-04-14 | Rockwell International Corporation | Two stage stepped piston air compressor |
| US4566868A (en) * | 1980-09-17 | 1986-01-28 | Geotechnical Digital Systems Limited | Pressure source |
| US4449897A (en) * | 1981-09-21 | 1984-05-22 | Garrett William R | Single-acting piston pump having two heads |
| US4493614A (en) * | 1982-10-08 | 1985-01-15 | Lifecare Services, Inc. | Pump for a portable ventilator |
| US4568249A (en) * | 1983-08-26 | 1986-02-04 | Todd James W | Variable reciprocating plunger pump |
| US4682712A (en) * | 1983-12-05 | 1987-07-28 | Boehnensieker Franz | Devices for the preparation of a mixture from at least two fluids with a definite mixture ratio |
| SE463221B (en) * | 1985-08-21 | 1990-10-22 | Tetra Pak Ab | Dosing pump |
| IT1186465B (en) * | 1985-12-18 | 1987-11-26 | Tetra Dev Co | PUMPING UNIT FOR FILLING CONTAINERS IN PACKAGING MACHINES |
| JPS62225780A (en) * | 1986-03-26 | 1987-10-03 | Noiberuku Kk | Continuously operating fluid device |
| GB8707881D0 (en) * | 1987-04-02 | 1987-05-07 | Furness Controls Ltd | Standard gas flow apparatus |
| US4941808A (en) * | 1988-06-29 | 1990-07-17 | Humayun Qureshi | Multi-mode differential fluid displacement pump |
| SU1613677A1 (en) * | 1989-01-31 | 1990-12-15 | Волгоградский сельскохозяйственный институт | Multistage positive-displacement machine with differential pistons |
| GB9104097D0 (en) * | 1991-02-27 | 1991-04-17 | Univ Hospital London Dev Corp | Computer controlled positive displacement pump for physiological flow stimulation |
-
1994
- 1994-04-28 US US08/234,282 patent/US5540562A/en not_active Expired - Lifetime
-
1995
- 1995-04-27 DE DE69514098T patent/DE69514098T2/en not_active Expired - Fee Related
- 1995-04-27 WO PCT/US1995/005199 patent/WO1995030089A1/en active IP Right Grant
- 1995-04-27 EP EP95919738A patent/EP0757757B1/en not_active Expired - Lifetime
- 1995-04-27 CA CA002188952A patent/CA2188952A1/en not_active Abandoned
- 1995-04-27 JP JP7528370A patent/JPH09512614A/en active Pending
-
1996
- 1996-07-18 US US08/685,188 patent/US5769615A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5769615A (en) | 1998-06-23 |
| EP0757757B1 (en) | 1999-12-22 |
| JPH09512614A (en) | 1997-12-16 |
| DE69514098D1 (en) | 2000-01-27 |
| US5540562A (en) | 1996-07-30 |
| WO1995030089A1 (en) | 1995-11-09 |
| DE69514098T2 (en) | 2000-07-13 |
| EP0757757A1 (en) | 1997-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2188952A1 (en) | Single-piston, multi-mode fluid displacement pump | |
| US4309156A (en) | Fluid activated pump having variable discharge | |
| US4715791A (en) | Metering pump | |
| US4405294A (en) | Dosing pump | |
| RU2474726C1 (en) | Pump unit with two pumps, system, application, and method | |
| US5817955A (en) | Apparatus for simultaneous aspiration and dispensation of fluids | |
| ATE106991T1 (en) | MULTIPLE DISPLACEMENT PUMP FOR DIFFERENT LIQUIDS. | |
| AR015955A1 (en) | DISPENSER ASSEMBLY FOR A FLUID PRODUCTS DISPENSING MACHINE | |
| WO2006044468A2 (en) | Multiple port dual diameter pumps | |
| KR880001938A (en) | Drive | |
| US3314371A (en) | Diaphragm pump | |
| CN210949012U (en) | Piston type metering pump | |
| US5024587A (en) | Valveless pump | |
| US5213132A (en) | Automatic regulating valve | |
| US6004117A (en) | Displacement pump | |
| EP0101161B1 (en) | Apparatus and method for passing two fluids simultaneously through an analytical flow cell | |
| GB2181494A (en) | Piston dosing pump for a fluid | |
| SU1760338A1 (en) | Metering pump | |
| WO2002031357A2 (en) | Fluid-moving device with integrated valve | |
| US11536266B2 (en) | Modular block for electric pump with limited space requirement and associated pump | |
| KR20010056540A (en) | device for mixing and dispensing two fluid materials | |
| SU877116A1 (en) | Positive-displacement pump | |
| SU1629624A1 (en) | Electric hydraulic pump | |
| SU1724932A1 (en) | Positive-displacement pump | |
| FI66978C (en) | CENTRALSMOERJNINGSSYSTEM OCH DOSERARE FOER ETT DYLIKT SYSTEM |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |