CA2189754A1 - Self-Emission Noninvasive Infrared Spectrophotometer - Google Patents

Self-Emission Noninvasive Infrared Spectrophotometer

Info

Publication number
CA2189754A1
CA2189754A1 CA2189754A CA2189754A CA2189754A1 CA 2189754 A1 CA2189754 A1 CA 2189754A1 CA 2189754 A CA2189754 A CA 2189754A CA 2189754 A CA2189754 A CA 2189754A CA 2189754 A1 CA2189754 A1 CA 2189754A1
Authority
CA
Canada
Prior art keywords
blood
constituents
infrared
measurements
infrared absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2189754A
Other languages
French (fr)
Other versions
CA2189754C (en
Inventor
James R. Braig
Daniel S. Goldberger
Roger O. Herrera
Bernhard B. Sterling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Optiscan Inc
Original Assignee
James R. Braig
Daniel S. Goldberger
Roger O. Herrera
Bernhard B. Sterling
Optiscan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by James R. Braig, Daniel S. Goldberger, Roger O. Herrera, Bernhard B. Sterling, Optiscan, Inc. filed Critical James R. Braig
Publication of CA2189754A1 publication Critical patent/CA2189754A1/en
Application granted granted Critical
Publication of CA2189754C publication Critical patent/CA2189754C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation

Abstract

A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured by infrared detector (412) at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle monitored by cardiac monitor (718) so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled by (418) when a ratio of the detected signals is taken. The concentration of the blood constituents is then determined in accordance with a polynomial equation.
CA002189754A 1994-05-23 1995-05-22 Self-emission noninvasive infrared spectrophotometer Expired - Fee Related CA2189754C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/247,311 US5515847A (en) 1993-01-28 1994-05-23 Self-emission noninvasive infrared spectrophotometer
US08/247,311 1994-05-23
PCT/US1995/006513 WO1995031930A1 (en) 1994-05-23 1995-05-22 Self-emission noninvasive infrared spectrophotometer

Publications (2)

Publication Number Publication Date
CA2189754A1 true CA2189754A1 (en) 1995-11-30
CA2189754C CA2189754C (en) 2000-08-29

Family

ID=22934429

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002189754A Expired - Fee Related CA2189754C (en) 1994-05-23 1995-05-22 Self-emission noninvasive infrared spectrophotometer

Country Status (6)

Country Link
US (1) US5515847A (en)
EP (1) EP0763999A4 (en)
JP (1) JP3590408B2 (en)
AU (1) AU683757B2 (en)
CA (1) CA2189754C (en)
WO (1) WO1995031930A1 (en)

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