CA2190180A1 - Use of Perfluorocarbons for Assisting Normal Breathing in Mammals Having Lung Disorders - Google Patents

Use of Perfluorocarbons for Assisting Normal Breathing in Mammals Having Lung Disorders

Info

Publication number
CA2190180A1
CA2190180A1 CA2190180A CA2190180A CA2190180A1 CA 2190180 A1 CA2190180 A1 CA 2190180A1 CA 2190180 A CA2190180 A CA 2190180A CA 2190180 A CA2190180 A CA 2190180A CA 2190180 A1 CA2190180 A1 CA 2190180A1
Authority
CA
Canada
Prior art keywords
lung
animal
hyperinflated
perfluorocarbons
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2190180A
Other languages
French (fr)
Other versions
CA2190180C (en
Inventor
Leland C. Clark, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tenax Therapeutics Inc
Original Assignee
Leland C. Clark, Jr.
Synthetic Blood International, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland C. Clark, Jr., Synthetic Blood International, Inc. filed Critical Leland C. Clark, Jr.
Publication of CA2190180A1 publication Critical patent/CA2190180A1/en
Application granted granted Critical
Publication of CA2190180C publication Critical patent/CA2190180C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung or hyperinflated lung syndrome, and instilling a perfluorochemical liquid into the trachea for administration in the alveolar sacs of a lung of the animal. The perfluorochemical is permeable to the ambient gas and resides substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O2/CO2 blood gas exchange. In another aspect of the invention, the method further includes the step of alleviating the lung disorder without inducing hyperinflated lung syndrome.
CA002190180A 1994-05-13 1995-05-12 Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders Expired - Fee Related CA2190180C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/242,310 US5674913A (en) 1994-05-13 1994-05-13 Method for assisting normal breathing in a mammal having a lung disorder
US08/242,310 1994-05-13
PCT/US1995/005993 WO1995031191A1 (en) 1994-05-13 1995-05-12 Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders

Publications (2)

Publication Number Publication Date
CA2190180A1 true CA2190180A1 (en) 1995-11-23
CA2190180C CA2190180C (en) 2000-10-03

Family

ID=22914268

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002190180A Expired - Fee Related CA2190180C (en) 1994-05-13 1995-05-12 Use of perfluorocarbons for assisting normal breathing in mammals having lung disorders

Country Status (8)

Country Link
US (1) US5674913A (en)
EP (1) EP0758886B1 (en)
JP (1) JPH10505319A (en)
AT (1) ATE220901T1 (en)
AU (1) AU690277B2 (en)
CA (1) CA2190180C (en)
DE (1) DE69527524D1 (en)
WO (1) WO1995031191A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5628930A (en) * 1992-10-27 1997-05-13 Alliance Pharmaceutical Corp. Stabilization of fluorocarbon emulsions
US5840767A (en) * 1995-12-01 1998-11-24 Synthetic Blood International, Inc. Perfluorocarbons for biological gas exchange and method
US6167887B1 (en) 1997-11-21 2001-01-02 Synthetic Blood International, Inc. Selected C-10 perfluorinated hydrocarbons for liquid ventilation and artificial blood
DE19823606C2 (en) * 1998-05-27 2002-02-28 Draeger Medical Ag Use of perfluorocarbons in a breathing gas mixture as well as the device
RU2206319C2 (en) * 2000-07-20 2003-06-20 Открытое акционерное общество Научно-производственная фирма "Перфторан" Emulsion of perorganofluoric compound for medicinal aim, method for its preparing and methods of treatment and prophylaxis of diseases with its using
EP1365068B1 (en) * 2002-05-10 2008-05-07 The Procter & Gamble Company Embossed tissue having loosened surface fibers and method for its production
US8535691B2 (en) * 2006-02-16 2013-09-17 Peach Technologies, LLC. Perflurochemical treatment process and apparatus
AU2007249200B2 (en) * 2006-05-15 2013-12-19 Virginia Commonwealth University Methods and compositions for controlled and sustained production and delivery of peroxides
CN101646442B (en) 2007-02-23 2013-09-04 21世纪国际新技术株式会社 Therapeutic or prophylactic agent for vasoconstriction
US20090202617A1 (en) * 2008-02-13 2009-08-13 Ward Kevin R Gas based wound and tissue therapeutics
EP2309849B1 (en) * 2008-07-18 2015-09-02 Tenax Therapeutics, Inc. Method of treating traumatic brain injury
US8343515B2 (en) 2008-11-25 2013-01-01 Oxygen Biotherapeutics, Inc. Perfluorocarbon gel formulations
US20100144597A1 (en) * 2008-12-10 2010-06-10 Ward Kevin R Novel combinatorial approaches to enhancing oxygen transport to tissues
US20110086923A1 (en) * 2009-07-28 2011-04-14 Thompson Deborah P Method to increase oxygen in male and female sexual organs through the topical use of perfluorocarbons
WO2012044963A2 (en) 2010-10-01 2012-04-05 Oxygen Biotherapeutics, Inc. Perfluorocarbons for use in treating pruritus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US4173654A (en) * 1977-01-03 1979-11-06 California Institute Of Technology Novel fluorohydrocarbons
EP0491685A4 (en) * 1989-08-28 1993-10-13 K. Michael Sekins Lung cancer hyperthermia via ultrasound and/or convection with perfluorocarbon liquids
US5437272A (en) * 1991-05-01 1995-08-01 Alliance Pharmaceutical Corp. Perfluorocarbon associated gas exchange
CA2102321C (en) * 1991-05-03 1999-11-09 Simon Nicholas Faithfull Partial liquid breathing of fluorocarbons
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
US5295953A (en) * 1992-05-26 1994-03-22 Hemagen/Pfc Method and apparatus for extracorporeal separation of fluorochemicals from whole blood of a patient

Also Published As

Publication number Publication date
CA2190180C (en) 2000-10-03
WO1995031191A1 (en) 1995-11-23
AU690277B2 (en) 1998-04-23
US5674913A (en) 1997-10-07
AU2549395A (en) 1995-12-05
EP0758886A1 (en) 1997-02-26
DE69527524D1 (en) 2002-08-29
JPH10505319A (en) 1998-05-26
ATE220901T1 (en) 2002-08-15
EP0758886B1 (en) 2002-07-24

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