CA2190753C - Anti-acne compositions - Google Patents

Anti-acne compositions Download PDF

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Publication number
CA2190753C
CA2190753C CA002190753A CA2190753A CA2190753C CA 2190753 C CA2190753 C CA 2190753C CA 002190753 A CA002190753 A CA 002190753A CA 2190753 A CA2190753 A CA 2190753A CA 2190753 C CA2190753 C CA 2190753C
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Prior art keywords
acne
composition according
composition
benzoyl peroxide
mixtures
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CA002190753A
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CA2190753A1 (en
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Ann Marie Corless
George Endel Deckner
Bonnie Joy Hall
Joseph Anthony Listro
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Reckitt and Colman Overseas Ltd
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Procter and Gamble Co
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38Percompounds, e.g. peracids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Abstract

The present invention relates to anti-acne compositions having good efficacy, low skin irritation, and good physical and chemical stability. These compositions comprise a benzoyl peroxide, a wetting agent, water, a non-volatile emollient component which is a liquid at 25 .degree.C and which has a weighted arithmetic mean solubility parameter of less than or equal to about 7, and a water soluble or dispersible gelling agent.

Description

WO 95/31978 9 ~ ~ 5 ~ PCT/ITS95104734 ANTI-ACNE COMPOSITIONS
TECHNICAL FIELD
The present invention relates to topical anti-acne compositions containing benzoyl peroxide. These compositions are effective for the treatment of acne and also have low skin irritation and good chemical and physical stability. In further embodiments, the present invention also relates io to methods for the treatment of acne.
BACKGROUND OF THE INVENTION
Acne is a common inflammatory pilosebaceous disease characterized by comedones, papules, pustules, inflamed nodules, and pus-filled cysts.
The pathogenesis of acne is complex and is believed to involve an is interaction between hormones, keratinization, sebum, and bacteria. Acne usually begins at puberty when the increase of androgens causes an increase in the size and activity of the sebum producing ducts. These ducts can subsequently become blocked, leading to hyperkeratinization and the formation of acne lesions.
2o Many topical therapeutic agents are employed in the treatment of acne. It is believed that these anti-acne agents work by preventing the blockage of the ducts, by reopening clogged ducts, by acting against infecting bacteria, and by providing a keratolytic effect. Compositions containing benzoyl peroxide are known to be effective for the treatment of 2s acne. For example, U.S. Patent No. 3,535,422, to Cox et al., issued October 20, 1970 discloses compositions containing dispersed benzoyl peroxide in a fluid medium containing water and an organic emollient; U.S.
Patent No. 4,609,674, to Gupte, issued September 2, 1986, discloses stable anhydrous compositions containing benzoyl peroxide in a C6 to C10 3o triglyceride; U.S. Patent No. 4,720,353 to Bell, issued January 19, 1988 discloses water-in-oil emulsion compositions containing benzoyl peroxide;
and U.S. Patent No. 4,387,107, to Klein et al., issued June 7, 1983 discloses aqueous benzoyl peroxide compositions employing dioctyl sodium sulfosuccinate as a wetting agent.
3s Even though the use of benzoyl peroxide for the treatment of acne is well known, benzoyl peroxide has the disadvantage of being very irritating to the skin, causing symptoms such as excessive drying, scaling, swelling, burning, peeling, redness, allergic contact dermatitis, and sensitization.
This irritation problem associated with benzoyl peroxide can cause a patient ao to discontinue or to reduce its usage, thereby sacrificing the anti-acne benefit. See, e.g., Brogden et al., Dru s 8, 417 (1974); Poole et al., Arch.
Derm. 102, 400 (1972); Eaglstein, Arch. Derm., 97,527 (1968); Pace, Can.
Med. Ass. J., 93, 252 (1965); Vasarinsh, Arch. Derm., 98, 183 (1968);
Mysliborski et al., AFP 15, 86 (1977) Hare, Br. J. Clin. Prac:, 29, 63 (1975);
as Fulton, et al., Arch. Derm., 110, 83 (1974); and Wilkinson, et al., Can.
Med Assn. J., 95, 28 (1966).
Many conventional benzoyl peroxide compositions also have poor physical and chemical stability, and tend to lose their anti-acne effectiveness and aesthetic qualities over relatively short periods of time.
so The compositions of the present invention have good anti-acne efficacy, have low skin irritancy, and are physically and chemically stable.
These compositions comprise a dispersion of benzoyl peroxide in a thickened vehicle containing water and a nonvolatile liquid emollient component wherein the weighted arithmetic mean solubility parameter of the ss constituents of the emollient is less than or equal to about 7. Without being limited by theory, it is believed that in.selecting an emollient component with this solubility parameter requirement that the solubilization of the benzoyl peroxide into the product vehicle is minimized, thereby reducing the incidence of unwanted skin irritation and other undesired side effects due to 6o excessive epidermal penetration. It is also believed that the emollient component provides the additional benefit of coating and soothing the skin, thereby further mitigating any potentially irritating effects from the benzoyl peroxide. Also, it is believed that the limited solubility of the benzoyl peroxide in the present compositions provides enhanced chemical and 6s physical stability of the compositions.
It is therefore an object of the present invention to provide topical compositions for the treatment of acne.
It is another object of the present invention to provide topical compositions for the treatment of acne, which comprise benzoyl peroxide as 7o the active ingredient, and which have good efficacy, low skin irritation, and good physical and chemical stability.
. _It is another object of the present invention to provide a method for treating acne in human skin.
These and other objects of this invention will become apparent in light 7s of the following disclosure.

WO 95/31978 ~ ~ 9 0 7 5 3 p~.~g95/04734 SUMMARY OF THE INVENTION
The present invention relates to an anti-acne composition comprising:
(a) from about 0.1 % to about 20% benzoyl peroxide, so (b) from about 0.01 % to about 10% of a wetting agent, (c) from about 20% to about 99.74% water, (d) from about 0.1 % to about 10% of a non-volatile emollient component which is a liquid at 25°C and which has a weighted arithmetic mean solubility parameter of less than or equal to about 7, and 8s (e) from about 0.05% to about 5% of a water soluble or dispersible gelling agent.
All percentages and ratios used herein are by weight of the total composition and all measurements made are at 25°C, unless otherwise designated. All weight percentages, unless otherwise indicated, are on an 9o actives weight basis. The invention hereof can comprise, consist of, or consist essentially of, the essential as well as optional ingredients and components described herein.
DETAILED DESCRIPTION OF THE INVENTION
The compositions of the present invention are useful for treating acne 9s in human skin, i.e. for providing an anti-acne benefit.
The term "chemical stability", as used herein, means that the compositions of the present invention do not exhibit an appreciable breakdown, degradation, disappearance, reaction, or consumption of the benzoyl peroxide. For example, the compositions of the present invention ioo typically retain at least about 80% of the initially added benzoyl peroxide over a period of about 3 months at 45°C.
The term "physical stability", as used herein, means that the compositions of the present invention exhibit physical characteristics such as pH stability, resistance to loss of viscosity, resistance to discoloration, ios resistance to developing off-odors, and the like. For example, the compositions of the present invention typically maintain their physical stability for at least about 3 months at 45°C.
The terms "chemical stability" and "physical stability" have been separately defined herein for convenience. Nevertheless, it is realized that to these two types of stability phenomena are not necessarily distinct and that chemical stability can impact physical stability and vice versa.

WO 95/31978 pCTIUS95/04734 The term "topical application", as used herein, means to apply or spread the anti-acne compositions to the surface of the skin.
The term "pharmaceutically-acceptable", as used herein, means that l is the compositions or components thereof so described are suitable for use in contact with human tissue without undue toxicity, incompatibility, instability, allergic response, and the like.
Benzoyl Peroxide The compositions of the present invention comprise from about 0.1 12o to about 20%, more preferably from about 0.5% to about 15%, and most preferably from about 2.5% to about 10% of benzoyl peroxide.
Benzoyl peroxide, which is also known as dibenzoyl peroxide, can be represented by the chemical formula C14H1004 and the following chemical structure.

C O -O -C
12s See The Merck Index, Tenth Edition, entry 1119, p. 159 (1983), In the compositions of the present invention, the benzoyl peroxide 13o particles are not limited to any particular size and can span a broad range of particle sizes. However, it is found that benzoyl peroxide particles having an -average particle size diameter from about 0.5 microns to about 40 microns are preferred. More preferred are those having an average particle size diameter from about 1 micron to about 20 microns. Most preferred are i3s those having an average particle size diameter from about 1 micron to about microns.
Wetting A4ent The compositions of the present invention comprise from about 0.01 to about 10%, more preferably from about 0.01 % to about 5%, and most l4o preferably from about 0.01 % to about 1 % of a wetting agent. The wetting agent can be a single chemical compound as well as mixtures of two or more chemical compounds.
s . 2190753 Without being limited by theory it is believed that the wetting agent coats the surface of the benzoyl peroxide particles and lowers their surface 14s tension, thereby helping to maintain the benzoyl peroxide as a dispersion in the formulation matrix and aiding the distribution of the benzoyl peroxide upon the skin.
A wide variety of wetting agents useful in the present invention are disclosed in McCutcheon's Volume 2: Functional Materials, North American lso Edition pp. 117-137 (1992) and CTFA Cosmetic Ingredient Handbook, Second Edition, p. 597 (Section Entitled Suspending Agents) (1992), A preferred wetting agent is a dimethicone copolyol, which is a polymer of dimethylsiloxane with polyoxyethylene andlor polyoxypropylene iss side chains. A typical dimethicone copolyol is represented by the chemical .
formula (CH3)3SiO[(CH3)2Si0]x[(CH3)RSiO]ySi(CH3)3 wherein R is C3H50(C2H40)m(C3Hg0)nH, x is an integer from about 1 to about 500, y is an integer from about 1 to about 500, m is ari integer from about 1 to about 250, and n is an integer from about 1 to about 250, (these integer i6o values being chosen to achieve the desired molecular weight and degree of ethoxylation and propoxylation). Examples of commercially available dimethicone copolyols useful herein are sold by Dow Coming Corporation as Dow Coming~ 190, 193, Q2-5220, 2501 Wax, 2-5324 fluid, and 3225C
(this later material being sold as a mixture with cyclomethicone). Preferred i6s among these materials are the Dow Coming~ 190 and 193 silicone copolyol materials. See DiSapio et al., "Silicone Glycols For Cosmetic And Toiletry Application", IFSCC, September 1988, London; Dow Coming Technical Bulletin, Shaping Solutions For Personal Care", 1993; U.S.
Patent No. 4,122,029, to Gee et al., issued October 24, 1978, U.S. Patent mo No. 4,265,878, to Keil, issued May 5, 1981; and U.S. Patent No. 4,421,769, to Dixon et al., issued December 20, 1983, Nonlimiting examples of other wetting agents include the following materials dioctyl sodium sulfosuccinate, sodium lauraminodipropionate, i7s caprylyl pyrollidone, dimethyl octynediol, tetramethyl decynediol, and mxitures thereof. Preferred among these other wetting agents is dioctyl sodium sulfosuccinate, which is described in the CTFA Cosmetic In4redient Handbook Second Edition 1992, p. 127, s .w 2194753 -1so Also, useful as wetting agents in the present invention are various fluorinated and perfluorined materials such as the Fluoradtm fluorochemical surfactants described in The 3M Company's Product Information Bulletin Entitled Flourad Fluorochemical Surfactants, March 1993ro A preferred fluorinated lss wetting agent among these materials is a fluorinated alkyl ester sold under the tradename FC-430.
Water The compositions of the present invention comprise from about 20% to about 99.74%, more preferably from about 50% to about 95%, and most 19o preferably from about 70% to about 90% of water.
Non-volatile Emollient Component The compositions of the present invention comprise from about 0.1 to about 10%, more preferably from about 0.5% to about 7.5%, and most preferably from about 1 % to about 5% of a non-volatile emollient component 19s that is a liquid at about 25°C and that has a weighted arithmetic mean solubility parameter of less than or equal to about 7. By "emollient"
component is meant that the material is soothing to the skin or mucous membranes and is effective in making the skin feel soft, smooth, or supple.
By "liquid at about 25°C" is meant that the emollient component has a Zoo melting point, at 1 atmosphere pressure, that is less than or equal to about 25°C. By "nonvolatile" is meant that the emollient component has a boiling point, at 1 atmosphere pressure, greater than or equal to about 100°C.
The emollient components useful herein can include a single chemical compound as well as mixtures of two or more chemical compounds as long Zos as the overall emollient component meets the melting point, boiling point, and solubility parameter requirements described herein.
The emollients useful herein preferably have a weighted arithmetic mean solubility parameter of less than or equal to about 7, preferably from about 1 to about 6.5, more preferably from about 5 to about 6.5, and most 21o preferably from about 5 to about 6. Solubility parameters are well known to the formulation chemist of ordinary skill in the art and are routinely used as a guide for determining compatibilities and solubilities of materials in the formulation process. Without being limited by theory, it is believed that by choosing a nonvolatile, liquid emollient component having a low solubility its parameter, that the solubility of the relatively polar benzoyl peroxide molecule in the emollient component will be minimized, thereby diminishing WO 95/31978 PC'T/US95/04734 undue skin irritation caused by excessive epidermal penetration of the benzoyl peroxide. Also, it is believed that the nonvolatile, liquid emollients provide the additional benefit of coating and soothing the skin, thereby 2ZO protecting against irritation by the benzoyl peroxide.
The solubility parameter of a chemical compound, 8, is defined as the square root of the cohesive energy density for that compound. Typically, a solubility parameter for a compound is calculated from tabulated values of the additive group contributions for the heat of vaporization and molar 22s volume of the components of that compound, using the following equation:
~ Ei i s -~ mi i 23o wherein Ei Ei = the sum of the heat of vaporization additive group contributions, and ~. m, = the sum of the molar volume additive group contributions i i Standard tabulations of heat of vaporization and molar volume additive group contributions for a wide variety of atoms and groups of atoms are 23s collected in Barton, A.F.M. Handbook of Solubility Parameters, CRC Press, Chapter 6, Table 3, pp. 64-66 (1985), .
The above solubility parameter equation is described in Fedors, R.F., "A Method for Estimating Both the Solubility Parameters and Molar Volumes of Liquids", Polymer Enaineerin4 and Science, vol. 14, 24o no. 2, pp. 147-154 (February 1974, _ _ Solubility parameters obey the law of mixtures such that the solubility parameter for a mixture of materials is given by the weighted arithmetic mean (i.e. the weighted average) of the solubility parameters for each 2as component of that mixture. See, Handbook of Chemistry and Physics, 57th 8 _ edition, CRC Press, p. C-726 (1976-1977.).
Formulation chemists typically report and use solubility parameters in units of (cal/cm3)1/2. The tabulated values of additive group contributions 2so for heat of vaporization in the Handbook of Solubility Parameters are reported in units of kJ/mol. However, these tabulated heat of vaporization values are readily converted to callmol using the following well-known relationships:
1 Jlmol = 0.239006 callmol and 1000 J = 1 kJ.
2ss See Gordon, A.J. et al., The Chemist's Companion, John Wiley 8~ Sons, pp.
456-463, (1972), Solubility parameters have also been tabulated for a wide variety of chemical materials. Tabulations of solubility parameters are found in the above-cited Handbook of Solubility Parameters.
26o A wide variety of nonvolatile emollients are useful herein, nonlimiting examples of which are listed in McCutcheon's, Vol. 2 Functional Materials.
North American Edition, (1992), pp. 137-168, and CTFA Cosmetic Inoredient Handbook, Second Edition (1992) which lists Skin-Conditioning Agents at pp. 572-575 2ss and Skin Protestants at p. 580, Among the nonvolatile emollient materials useful herein especially preferred are silicones, hydrocarbons, esters, and mixtures thereof.
Examples of silicone emollients include polyalkylsiloxanes, cyclic 27o polyalkylsiloxanes, and polyalkylarylsiloxanes. The polyalkylsiloxanes useful herein include, for example, polyalkylsiloxanes with viscosities of from about 0.5 to about 100,000 centistokes at 25°C. Such polyalkylsiloxanes correspond to the general chemical formula R3Si0[R2Si0]xSiR3 wherein R is an alkyl group (preferably R is methyl or 27s ethyl, more preferably methyl) and x is an integer from 0 to about 500, chosen to achieve the desired molecular weight. Commercially available polyalkylsiloxanes include the polydimethylsiloxanes, which are also known as dimethicones, nonlimiting examples of which include the Vicasil~ series sold by General Electric Company and the Dow Coming~ 200 series sold ego by Dow Coming Corporation. Specific examples of polydimethyisiloxanes useful as emollients herein include Dow Corning~ 200 fluid having a viscosity of 0.65 centistokes and a boiling point of 100°C, Dow Coming~
225 fluid having a viscosity of 10 centistokes and a boiling point greater than 200°C, and Dow Corning~ 200 fluids having viscosities of 50, 350, and 28s 12,500 centistokes, respectively, and boiling points greater than 200°C.
Cyclic polyalkylsiloxanes useful herein include those corresponding to the general chemical formula [SiR2-O]n wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl) and n is an integer from about 3 to about 8, more preferably n is an integer from about 3 to about 7, and 29o most preferably n is an integer from about 4 to about 6. When R is methyl, these materials are typically referred to as cyclomethicones. Commercially available cyclomethicones include Dow Corning~ 244 fluid having a viscosity of 2.5 centistokes, and a boiling point of 172°C, which primarily contains the cyclomethicone tetramer (i.e. n=4), Dow Corning~ 344 fluid 29s having a viscosity of 2.5 centistokes and a boiling point of 178°C, which primarily contains the cyclomethicone pentamer (i.e. n=5), Dow Coming~
245 fluid having a viscosity of 4.2 centistokes and a boiling point of 205°C, which primarily contains a mixture of the cyclomethicone tetramer and pentamer (i.e. n=4 and 5), and Dow Coming~ 345 fluid having a viscosity of 300 4.5 centistokes and a boiling point of 217°, which primarily contains a mixture of the cyclomethicone tetramer, pentamer, and hexamer (i.e. n=4, 5, and 6). Also useful are materials such as trimethylsiloxysilicate, which is a polymeric material corresponding to the general chemical formula [(CH2)3Si01~21x[Si02]y, wherein x is an integer from about 1 to about 500 3os and y is an integer from about 1 to about 500. A commercially available trimethylsiloxysilicate is sold as a mixture with dimethicone as Dow Coming ~ 593 fluid. Also useful herein are dimethiconols, which are hydroxy terminated dimethyl silicones. These materials can be represented by the general chemical formulas R3Si0[R2Si0JXSiR20H and 3io HOR2Si0[R2Si0]xSiR20H wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl) and x is an integer from 0 to about 500, chosen to achieve the desired molecular weight. Commercially available dimethiconols are typically sold as mixtures with dimethicone or cyclomethicone (e.g. Dow Coming~ 1401, 1402, and 1403 fluids). Also 31s useful herein are polyalkylaryl siloxanes, with polymethylphenyl siloxanes having viscosities from about 15 to about 65 centistokes at 25°C being preferred. These materials are available, for example, as SF 1075 methylphenyl fluid (sold by General Electric Company) and 556 Cosmetic Grade phenyl trimethicone fluid (sold by Dow Corning Corporation).
32o Hydrocarbons useful herein include straight and branched chain hydrocarbons having from about 10 to about 30 carbon atoms, more preferably from about 12 to about 24 carbon atoms, and most preferably from about 16 to about 22 carbon atoms. Nonlimiting examples of these hydrocarbon materials include dodecane, squalane, cholesterol, 32s hydrogenated polyisobutylene, docosane (i.e. a C22 hydrocarbon), hexadecane, isohexadecane (a commercially available hydrocarbon sold as Permethyl~ 101A by Presperse, South Plainfield, NJ). Other hydrocarbon materials useful herein include paraffins and mineral oils such as USP light mineral oil (e.g., Klearol~ available from Witco Corp., Melrose Park, IL) and 33o USP heavy mineral oil (e.g. Klearol~ available from Witco Corp., Melrose Park, IL).
Also useful as nonvolatile emollients are esters, including esters of monofunctional and difunctional fatty acids that have been esterified with alcohols and polyols (i.e. alcohols having two or more hydroxy groups). A
s3s wide variety of esters are useful herein, with long chain esters of long chain fatty acids being preferred (i.e. C10-40 fatty acids esterified with C10-40 fatty alcohols). Nonlimiting examples of esters useful herein include those selected from the group consisting of diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol 34o distearate, 2-ethylhexyl palmitate, isodecyl neopentanoate, C12_15 alcohols benzoate, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenrate, and mixtures thereof.
Water Soluble or Dispersible Gellin4 Agent The compositions of the present invention comprise from about 0.05%
34s to about 5%, more preferably from about 0.1 % to about 2.5%, and most preferably from about 0.25% to about 1 % of a water soluble or dispersible gelling agent. By 'wvater soluble or dispersible" as used herein means that the gelling agents are soluble or dispersible in water at a level of at least about 0.25% by weight at 25°C. The gelling agent can be a single chemical 3so compound as well as mixtures of two or more chemical compounds.
Nonlimiting classes of water soluble or dispersible gelling agents include those selected from the group consisting of carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums, vinyl ether/maleic anhydride copolymers, r 2190753 ass crosslinked poly(N-vinylpyrrolidones), and mixtures thereof. See U.S.
Patent No., 4,387,107, to Klein et al., issued June 7, 1983 which lists a variety of thickening or gelling agents Carboxylic Acid Polymers These polymers are crosslinked 36o compounds containing one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and the substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol.
The preferred carboxylic acid polymers are of two general types. The first 36s type of polymer is a crosslinked homopolymer of an acrylic acid monomer or derivative thereof (e.g., wherein the acrylic acid has substituents on the two and three carbon positions independently selected from the group consisting of C1~ alkyl, -CN, -COOH, and mixtures thereof). The second type of polymer is a crosslinked copolymer having a first monomer selected 37o from the group consisting of an acrylic acid monomer or derivative thereof (as just described in the previous sentence), a short chain alcohol (i.e. a C1~) acrylate ester monomer or derivative thereof (e.g., wherein the acrylic acid portion of the ester has substituents on the two and three carbon positions independently selected from the group consisting of C alkyl, -37s CN, -COOH, and mixtures thereof), and mixtures thereof; andl a second monomer which is a long chain alcohol (i.e. C8~0) acryiate ester monomer or derivative thereof (e.g., wherein the acrylic acid portion of the ester has substituents on the two and three carbon positions independently selected from the group consisting of C~~ alkyl, -CN, -COOH, and mixtures thereof).
38o Combinations of these two types of polymers are also useful herein.
In the first type of crosslinked homopolymers the monomers are preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacryiic acid, and mixtures thereof, with acrylic acid being most preferred. In the second type of crosslinked copolymers the acrylic acid ass monomer or derivative thereof is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid, methacrylic acid, and mixtures thereof being most preferred. The short chain alcohol acrylate ester monomer or derivative thereof is preferably selected from the group consisting of C alcohol s9o acrylate esters, C 1 ~ alcohol methacrylate esters, C 1 ~ alcohol ethacrylate esters, and mixtures thereof, with the C 1 ~ alcohol acrylate esters, C 1 ~

alcohol methacrylate esters, and mixtures thereof, being most preferred.
The long chain alcohol acrylate ester monomer is selected from C alkyl acrylate esters, with C 10_30 alkyl acrylate esters being preferred. 8~0 39s The crosslinking agent in both of these types of polymers is a polyalkenyl polyether of a polyhydric alcohol containing more than one alkenyl ether group per molecule, wherein the parent polyhydric alcohol contains at least 3 carbon atoms and at least 3 hydroxyl groups. Preferred crosslinkers are those selected from the group consisting of allyl ethers of 40o sucrose and allyl ethers of pentaerythritol, and mixtures thereof. These polymers useful in the present invention are more fully described in U.S.
Patent No. 5,087,445, to Haffey et al., issued February 11, 1992; U.S.
Patent No. 4,509,949, to Huang et al., issued April 5, 1985; U.S. Patent No.
2,798,053, to Brown, issued July 2, 1957;.
4os ~ See also, CTFA International Cosmetic Ingredient Dictionary, fourth edition, 1991, pp. 12 and 80;, Examples of commercially availble hompolymers of the first type useful herein include the carbomers, which are homopolymers of acrylic 4to acid crosslinked with allyl ethers of sucrose or pentaerytritol. The carbomers are available as the Carbopoi~ 900 series from B.F. Goodrich.
Examples of commercially available copolymers of the second type useful herein include copolymers of C alkyl acrylates with one or more monomers of acrylic acid, methacrylic acid, or one of their short chain (i.e.
4ts C1~ alcohol) esters, wherein the crosslinking agent is an allyl ether of sucrose or pentaerytritol. These copolymers are known as acrylates/C10-30 alkyl acrylate crosspolymers and are commerically available as Carbopol ~ 1342, Pemulen TR-1, and Pemuien TR-2, from B. F. Goodrich. In other words, examples of carboxylic acid polymer thickeners useful herein are 42o those selected from the group consisting of carbomers, acrylates/C10-C30 alkyl acrylate crosspolymers, and mixtures thereof.
Crosslinked Polvacrvlate Polymers The crosslinked polyacrylate polymers useful as thickeners include both cationic and nonionic polymers, with the cationics being generally preferred. Examples of useful crosslinked 42s nonionic polyacrylate polymers and crosslinked cationic polyacrylate polymers are those described in U.S. Patent 5,100,660, to Hawe et al., issued March 31, 1992; U.S. Patent 4,849,484, to Heard, issued July 18, 1989; U.S. Patent 4,835,206, to Farrar et al., issued May 30, 1989; U.S.

~ ~~gp753 WO 95/31978 ' PCT/US95/04734 Patent 4,628,078 to Glover et al. issued December 9, 1986; U.S. Patent 430 4,599,379 to Flesher et al. issued July 8, 1986; and EP 228,868, to Farrar et al., published July 15, 1987. , The crosslinked polyacrylate polymers are high molecular weight materials that can be characterized by the general formula:
(A) (B) (C) 43s and comprise the monomer units (A) , (B) , wherein) (A~ is a , and (C) I
m n dialkylaminoalkyl acrylate monomer or its quaternary ammonium or acid addition salt, (B) is a dialkylaminoalkyl methacrylate monomer or its quaternary ammonium or acid addition salt, (C) is a monomer that is polymerizable with (A) or (B), for example a monomer having a carbon-aao carbon double bond or other such polymerizable functional group, I is an integer of 0 or greater, m is an integer of 0 or greater, n is an integer of 0 or greater, but where either I or m, or both, must be 1 or greater.

The (C) monomer can be selected from any of the commonly used monomers. Nonlimiting examples of these monomers include ethylene, aas propylene, butylene, isobutylene, eicosene, malefic anhydride, acrylamide, methacrylamide, malefic acid, acrolein, cyclohexene, ethyl vinyl ether, and methyl vinyl ether. In the cationic polymers of the present invention, (C) is preferably acrylamide. The alkyl portions of the (A) and (B) monomers are short chain length alkyls such as C -C , preferably C -C
, more preferably 4so C
-C
, and most preferably C
-C2 When quatemz ed,5the polymers are preferably quatemized with short chain alkyls, i.e., C -C
, preferably C -C5, more preferably C -C
, and most preferably C
-C2. The acid addition salts refer to polymers having protonated amino groups.
Acid addition salts can be performed through the use of halogen (e.g. chloride), acetic, ass phosphoric, nitric, citric, or other acids.

These (A) (B) (C) polymers also comprise a crosslinking agent, I
m n which is most typically a material containing two or more unsaturated functional groups. The crosslinking agent is reacted with the monomer units of the polymer and is incorporated into the polymer thereby forming links or 4so covalent bonds between two or more individual polymer chains or between two or more sections of the same polymer chain. Nonlimiting examples of suitable crosslinking agents include those selected from the group consisting of methylenebisacrylamides, diallyldialkyl ammonium halides, polyalkenyl polyethers of polyhydric alcohols, ally) acrylates, i a6s v nyloxyalkylacrylates, and polyfunctional vinylidenes. Specific examples of WO 95/31978 ~ ~ 9 0 7 5 3 PCT/US95/04734 crosslinking agents useful herein include those selected from the group consisting of methylenebisacrylamide, ethylene glycol di-(meth)acrylate, di-(meth)acrylamide, cyanomethylacrylate, vinyloxyethylacrylate, vinyloxyethylmethacrylate, allyl pentaerythritol, trimethylolpropane 47o diallylether, allyl sucrose, butadiene, isoprene, divinyl benzene, divinyl naphthalene, ethyl vinyl ether, methyl vinyl ether, and allyl acrylate. Other crosslinkers include formaldehyde and glyoxal. Preferred for use herein as a crosslinking agent is methylenebisacrylamide.
Widely varying amounts of the crosslinking agent can be employed 47s depending upon the properties desired in the final polymer, e.g.
viscosifying effect. Without being limited by theory, it is believed that incorporation of a crosslinking agent into these cationic polymers provides a material that is a more effective viscosifying agent without negatives such as stringiness and viscosity breakdown in the presence of electrolytes. The crosslinking agent, 48o when present, can comprise from about 1 ppm to about 1000 ppm, preferably from about 5 ppm to about 750 ppm, more preferably from about 25 ppm to about 500 ppm, even more preferably from about 100 ppm to about 500 ppm, and most preferably from about 250 ppm to about about 500 ppm of the total weight of the polymer on a weight/weight basis.
ass The intrinsic viscosity of the crosslinked polymer, measured in one molar sodium chloride solution at 25oC, is generally above 6, preferably from about 8 to about 14. The molecular weight (weight average) of the crosslinked polymers hereof is high, and is believed to typically be between about 1 million and about 30 million. The specific molecular weight is not 49o critical and lower or higher weight average molecular weights can be used as long as the polymer retains its intended viscosifying effects in water or other aqueous carriers of the compositions hereof. Preferably, a 1.0%
solution of the golymer (on an actives basis) in deionized water will have a viscosity at 25 C of at least about 20,000 cP, preferably at least about 49s 30,000 cP, when measured at 20 RPM by a Brookfield RVT (Brookfield Engineering Laboratories, Inc. Stoughton, MA, USA).
These cationic polymers can be made by polymerization of an aqueous solution containing from about 20% to about 60%, generally from about 25% to about 40%, by weight monomer, in the presence of an initiator soo (usually redox or thermal) until the polymerization terminates. The crosslinking agent can also be added to the solution of the monomers to be polymerized, to incorporate it into the polymer. In the polymerization reactions, the temperature generally starts between about Oo and 95 C.
The polymerization can be conducted by forming a reverse phase sos dispersion of an aqueous phase of the monomers (and also any additional crosslinking agents) into a nonaqueous liquid, e.g. mineral oil, lanolin, isododecane, oleyl alcohol, and other volatile and nonvolatile esters, ethers, and alcohols, and the like.
All percentages describing the polymer in this section of the sio description herein are molar, unless otherwise specified. When the polymer contains (C) monomer, the molar proportion of (C) monomer, based on the total molar amount of (A), (B), and (C), can be from 0% to about 99%. The molar proportions of (A) and (B) can each be from 0% to 100%. When acrylamide, is used as the (C) monomer, it will preferably be used at a level sls of from about 20% to about 99%, more preferably from about 50% to about 90%.
Where monomer (A) and (B) are both present, the ratio of monomer (A) to monomer (B) in the final polymer, on a molar basis, is preferably from about 99:5 to about 15:85, more preferably from about 80:20 to about 20:80.
s2o Alternatively, in another class of polymers, the ratio is from about 5:95 to about 50:50, preferably from about 5:95 to about 25:75.
In another alternative class of polymers, the ratio (A):(B) is from about 50:50 to about 85:15. Preferably the ratio (A):(B) is about 60:40 to about 85:15, most preferably about 75:25 to about 85:15.
s2s Most preferred is where monomer (A) is not present and the ratio of monomer (B):monomer (C) is from about 30:70 to about 70:30, preferably from about 40:60 to about 60:40 and most preferably from about 45:55 to about 55:45.
Cationic polymers that are useful herein that are especially preferred sso are those conforming to the general structure (A)I(B) (C)n wherein I is zero, (B) is methyl quatemized dimethylaminoethyl met~acryiate, the ratio of (B):(C) is from about 45:55 to about 55:45, and the crosslinking agent is methylenebisacrylamide. An example of such a cationic polymer is one that is commercially available as a mineral oil dispersion (which can also include sss various dispersing aids such as PPG-1 trideceth~) under the trademark Salcare~ SC92 from Allied Colloids Ltd. (Norfolk, Virginia). This polymer has the proposed CTFA designation, "Polyquaternium 32 (and) Mineral Oil".
Other cationic polymers useful herein, are those not containing acrylamide or other (C) monomers, that is, n is zero. In these polymers the WO 95/31978 ~ PCT/US95/04734 sao (A) and (B) monomer components are as described above. An especially preferred group of these non-acrylamide containing polymers is one in which I is also zero. In this instance the polymer is essentially a homopolymer of a dialkylaminoalkyl methacrlyate monomer or its quaternary ammonium or acid addition salt. These diaklylaminoalkyl methacrylate sas polymers preferably contain a crosslinking agent as described above.
A cationic polymer, which is essentially a homopolymer, useful herein is one conforming to the general structure (A) (B) (C) wherein I is zero, (B) is methyl quaternized dimethylaminoethyl rnethacrylate, n is zero, and the crosslinking agent is methylenebisacrylamide. An example of such a sso homopolymer is commercially available as a mixture containing approximately 50% of the polymer, approximately 44% mineral oil, and approximately 6% PPG-1 trideceth-6 as a dispersing aid, from Allied Colloids Ltd, (Norfolk, VA) under the trademark Salcare~ SC95. This polymer has recently been given the CTFA designation "Polyquaternium 37 sss (and) Mineral Oil (and) PPG-1 Trideceth-6".
Polyacrvlamide Polymers Also useful herein are polyacrylamide polymers, especially non-ionic polyacrylamide polymers including substituted branched or unbranched polymers. These polymers can be formed from a variety of monomers including acrylamide and methacrylamide which are s6o unsubstituted or subtituted with one or two alkyl groups (preferably C1 to C5). Preferred are acrylate amide and methacrylate amide monomers in which the amide nitrogen is unsubstituted, or substituted with one or two C1 to C5 alkyl groups (preferably methyl, ethyl, or propyl), for example, acrylamide, methacrylamide, N-methacrylamide, N-methylmethacrylamide, s6s N,N-dimethylmethacrylamide, N-isopropylacrylamide, N-isopropylmethacrylamide, and N,N-dimethylacrylamide. These polymers have a molecular weight greater than about 1,000,000 preferably greater than about 1,5000,000 and range up to about 30,000,000. Most preferred among these polyacrylamide polymers is the non-ionic polymer given the s7o CTFA designation polyacrylamide and isoparaffin and laureth-7, available under the Tradename Sepigel from Seppic Corporation (Fai~eld, NJ).
Other polyacrylamide polymers useful herein include mufti-block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids. Commercially available examples of these s7s mufti-block copolymers include Hypan SR150H, SS500V, SS500W, SSSA100H, from Lipo Chemicals, Inc., (Patterson, NJ).

Polysaccharides A wide variety of polysaccharides are useful herein. By "polysaccharides" are meant gelling agents containing a backbone of repeating sugar (i.e. carbohydrate) units. Nonlimiting examples of sso polysaccharide gelling agents include those selected from the group consisting of cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose s8s sulfate, and mixtures thereof. Also useful herein are the alkyl substituted celluloses. In these polymers, the hydroxy groups of the cellulose polymer is hydroyxalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose which is then further modified with a C10-C30 straight chain or branched chain alkyl group through an ether linkage.
s9o Typically these polymers are ethers of C10-C30 straight or branched chain alcohols with hydroxyalkylcelluloses. Examples of alkyl groups useful herein include those selected from the group consisting of stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl (i.e. alkyl groups derived from the alcohols of coconut oil), palmityl, oleyl, linoleyl, linolenyl, ricinoleyl, s9s behenyl, and mixtures thereof.
Preferred among the alkyl hydroxyalkyl cellulose ethers is the material given the CTFA designation cetyl hydroxyethylcellulose, which is the ether of cetyl alcohol and hydroxyethylcellulose. This material is sold under the tradename Natrosol~ CS Plus from Aqualon Corporation. Other useful 60o polysaccharides include scleroglucans comprising a linear chain of (1->3) linked glucose units with a (1->6) linked glucose every three units, a commercially available example of which is Clearogeltm CS11 from Michel Mercier Products Inc. (Mountainside, NJ).
ums Other gelling agents useful herein include materials which are 6os primarily derived from natural sources. Nonlimiting examples of these gelling agent gums include materials selected from the group consisting of acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, bentonite, calcium alginate, calcium carrageenan, carnitine, carrageenan, com starch, dextrin,. gelatin, gellan gum, guar gum, guar 6io hydroxypropyltrimonium chloride, hectorite, hyaluroinic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, magnesium aluminum silicate, manesium silicate, magnesium trisilicate, montmorillonite. natto gum, potassium alginate, potassium . 2190753 carrageenan, propylene glycol alginate, sclerotium gum, sodium 61s carboyxmethyl dextran, sodium carrageenan, sodium polyacrylate starch, sodium silicoaluminate, starchlacrylates/acrylamide copolymer, tragacanth gum, xanthan gum, and mixtures thereof.
Crosslinked Vinyl EtherIMaleic Anhydride Copolymers Other gelling agents useful herein include crosslinked copolymers of alkyl vinyl ethers and 6zo malefic anhdride. In these copolymers the vinyl ethers are represented by the formula R-O-CH==CH2 wherein R is a C1-C6 alkyl group, preferably R
is methyl. Preferred crosslinking agents are C4-C20 dienes, preferably C6 to C16 dienes, and most preferably C8 to C12 dienes. A particularly preferred copolymer is one formed from methyl vinyl ether and malefic 62s anhydride wherein the copolymer has been crosslinked with decadiene, and wherein the polymer when diluted as a 0.5% aqueous solution at pH 7 at 25 °C has a viscosity of 50,000-70,000 cps when measured using a Brookfield RTV viscometer, spindle #7 at 10 rpm. This copolymer has the CTFA
designation PVM/MA decadiene crosspolymer and is commercially available 63o as Stabileze~" 06 from International Specialty Products (Wayne NJ).
Crosslinked aoly(N-vinylpyrrolidones) Crosslinked polyvinyl(N-pyrrolidones) useful herein as gelling agents include those described in U.S. Patent No. 5,139,770, to Shih et al, issued August 18, 1992, and U.S.
Patent No. 5,073,614, to Shih et al., issued December 17, 19910 63s These gelling agents typically contain from about 0.25% to about 1 % by weight of a crosslinking agent selected from the group consisting of divinyl ethers and diallyl ethers of terminal diols containing from about 2 to about 12 carbon atoms, divinyl ethers and diallyl ethers of polyethylene glycofs 6ao containing from about 2 to about 600 units, dienes having from about 6 to about 20 carbon atoms, divinyl benzene, vinyl and allyl ethers of pentaerythritol, and the like. Typically, these gelling agents have a viscosity from about 25,000 cps to about 40,000 cps when measured as a ~5%
aqueous solution at 25°C using a Brookfield RVT viscometer with Spindle Gas #6 at 10 rpm. Commercially available examples of these polymers include ACP-1120, ACP-1179, and ACP-1180, available from International Specialty Products (Wayne, NJ).
Additional Components The compositions of the present invention can comprise a wide range 6so of additional components. The CTFA Cosmetic In4redient Handbook, WO 95131978 ' ~ 1 9 0 ~ ~ ~ p~~S95/04734 Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of nonlimiting cosmetic and pharamceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention.
6ss Nonlimiting examples of functional classes of ingredients are described at page 537 of this reference. Examples of these functional classes include:
abrasives, absorbents, other anti-acne agents, anticaking agents, antifoaming agents, antimicrobial agents, antioxidants, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical 66o additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, external analgesics, film formers, fragrance components, humectants, opacifying agents, pH adjusters, preservatives, propellants, reducing agents, skin bleaching agents, skin-conditioning agents (humectants, miscellaneous, and occulsive), sunscreen agents, and ~s ultraviolet light absorbers.
Some nonlimiting examples of these additional components cited in the CTFA Cosmetic In4redient Handbook, as well as other materials useful herein, include the following: vitamins and derivatives thereof (e.g tocopherol, tocopherol acetate, retinoic acid, retinol, retinoids, and the like);
67o polymers for aiding the film-forming properties and substantivity of the composition (such as a copolymer of eicosene and vinyl pyrrolidone, an example of which is available from GAF Chemical Corporation as Ganex~
V-220); preservatives for maintaining the antimicrobial integrity of the compositions; other anti-acne medicaments (e.g., resorcinol, sulfur, salicylic 67s acid, erythromycin, zinc, and the like); skin bleaching (or lightening) agents including but not limited to hydroquinone, kojic acid; antioxidants; chelators and sequestrants; and aesthetic components such as fragrances, pigments, colorings, essential oils, skin sensates, astringents, skin soothing agents, skin healing agents and the like, nonlimiting examples of these aesthetic 6so components include panthenol and derivatives (e.g. ethyl panthenol), aloe vera, pantothenic acid and its derivatives, clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate, allantoin, bisabolol, dipotassium glycyrrhizinate and the like; and skin conditioning agents such as the propoxylated glycerols described in U.S. Patent No.
6ss 4,976,953, to Orr et al., issued December 11, 1990, Methods For Treatin4 Acne WO 95/31978 ~ ~ ~ ~ 7 5 3 PCT/US95/04734 The compositions of the present invention are useful for treating acne in human skin. To obtain an anti-acne benefit, an effective amount of the 69o compositions of the present invention are applied to the skin. The term "effective" means an amount of the compositions of the present invention to provide an anti-acne benefit, but not so much as to cause any undesirable side effects or skin reactions.
A wide range of quantities of the compositions of the present invention 69s can be employed to provide an anti-acne benefit. Quantities of the present compositions which are typically applied to provide an anti-acne benefit can range from about 0.1 mglcm2 to about 10 mg/cm2. A particularly useful amount to use is about 2 mg/cm2.
EXAMPLES
70o The following examples further describe and demonstrate embodiments within the scope of the present invention. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.
7os Ingredients are identified by chemical or CTFA name.

Anti-Acne Gel An anti-acne gel is prepared by combining the following ingredients 7io using conventional mixing techniques.
In4redients Weight Percent Water qs100 ms Benzoyl Peroxidel 10.00 Carbomer 9802 0.65 Disodium EDTA 0.10 Sodium Hydroxide 0.12 Dimethicone Copolyol3 0.10 72o Dimethicone4 1.0 1 Lucidol~ 70 from Elf Atochem, which is a powder containing 70% benzoyl peroxide active. 14.29% percent of this powder is added to the composition to account for the 70% activity .

72s 2 Carbopol~ 980 from B.F. Goodrich.
3 Dow Corning~ 193 from Dow Corning.
4 Dow Corning~ 200 Fluid (350 centistoke) from Dow Corning.
In a suitable vessel a benzoyl peroxide slurry is prepared by 73o combining the benzoyl peroxide with approximately 17% of the water. This slurry is passed through a Colloid or Urschel mill to disperse the benzoyl peroxide, followed by rinsing the mill with approximately an additional 6% of the water, this rinse being added to the total slurry.
In a separate vessel a 5% sodium hydroxide solution is prepared 7ss using approximately 2.5% of the water.
In another vessel the carbomer 980 is gradually combined with the remaining water with agitation to disperse and hydrate the carbomer. The carbomer dispersion is then transferred to a vessel equipped with a high shear mixer (Day Mixer, Serial No. 88612, Day Mixing, Cincinnati, OH) for 7ao blending the remaining ingredients. Next, the disodium EDTA is added and mixed until dissolved. The dimethicone copolyol is then added and stirred until uniform. Next, the benzoyl peroxide slurry is added and the mixture is stirred until uniform. The dimethicone is then added and the mixture stirred for 5 minutes to fully disperse the silicone. Next, the 5% NaOH solution is 74s gradually added with continuous mixing. The compositions is then mixed for 3-5 minutes until homogeneous.
The resulting anti-acne composition exhibits tow skin irritation and good physical and chemical stability, and is useful for topical application to human skin for the treatment of acne.
7so Anti-Acne Gel An antiacne gel is prepared by combining the following ingredients using conventional mixing techniques.
75s In4redients Weight Percent Water qs100 Benzoyl Peroxidel 10.00 76o Carbomer 9802 0.65 Disodium EDTA 0.10 21,9053 Sodium Hydroxide 0.12 Bentonite 1.0 Dimethicone Copolyol3 0.10 7ss Dimethicone4 1.0 1 Lucidol~ 70 from Elf Atochem, which is a powder containing 70% benzoyl peroxide active. 14.29% percent of this powder is added to the composition to account for the 70% activity.
770 2 Carbopol~ 980 from B. F. Goodrich.
3 Dow Coming~ 193 from Dow Corning.
4 Dow Coming~ 200 Fluid (350 centistoke) from Dow Corning.
In a suitable vessel a benzoyl peroxide slurry is prepared by 77s combining the benzoyl peroxide with 17% of the water. This slurry is passed through a Colloid or Urschel mill to disperse the benzoyl peroxide, followed by rinsing the mill with approximately an additional 6% of the water, this rinse being added to the total slung.
In a separate vessel a 5% sodium hydroxide solution is prepared 7so using 2.5% of the water.
In another vessel the carbomer 980 is gradually combined with the remaining water with agitation to disperse and hydrate the carbomer. The carbomer dispersion is then transferred to a vessel equipped with a high shear mixer (Day Mixer, Serial No. 88612, Day Mixing, Cincinnati, OH) for 7ss blending the remaining ingredients. Next, the disodium EDTA is added and mixed until dissolved. The dimethicone copolyol is then added and stirred until uniform. The bentonite is added to the mixture which is stirred with sufficient agitation until dispersed. Next, the benzoyl peroxide slung is added and the mixture is stirred until uniform. The dimethicone is then 79o added and the mixture stirred for 5 minutes to fully disperse the silicone.
Next, the 5% NaOH solution is gradually added with continuous mixing.
The compositions is then mixed for 3-5 minutes until homogeneous.
The resulting anti-acne composition exhibits low skin irritation and good physical and chemical stability, and is useful for topical application to 79s human skin for the treatment of acne.

Anti-Acne Gel v z~ 9oos~

An antiacne gel is prepared by combining the following ingredients using conventional mixing techniques.
soo In4redients Weight Percent Water qs100 Benzoyl Peroxidel 2.50 gos Carbomer 9802 0.65 Disodium EDTA 0.10 Sodium Hydroxide 0.12 Bentonite 1.0 Dimethicone Copolyol3 0.10 glo Dimethicone4 1.0 1 Lucidol~ 70 from Elf Atochem, which is a powder containing 70% benzoyl peroxide active. 3.57% percent of this powder is added to the composition to account for the 70% activity.
sls 2 Carbopol~ 980 from B.F. Goodrich.
3 Dow Coming~ 193 from Dow Corning.
4 Dow Coming~ 200 Fluid (350 centistoke) from Dow Coming.
In a suitable vessel a benzoyl peroxide slurry is prepared by $2o combining the benzoyl peroxide with 17% of the water. This slurry is passed through a Colloid or Urschei mill to disperse the benzoyl peroxide, followed by rinsing the mill with approximately an additional 6°~ of the water, this rinse being added to the total slurry.
In a separate vessel a 5% sodium hydroxide solution is prepared s2s using 2.5°r6 of the water.
In another vessel the carbomer 980 is gradually combined with the remaining water with agitation to disperse and hydrate the carbomer. The carbomer dispersion is then transferred to a vessel equipped with a high shear mixer (Day Mixer, Serial No. 88612, Day Mixing, Cincinnati, OH) for 83o blending the remaining ingredients. Next, the disodium EDTA is added and mixed until dissolved. The dimethicone copolyol is then added and stirred until uniform. The bentonite is added to the mixture which is stirred with sufficient agitation until dispersed. Next, the benzoyl peroxide slurry is added and the mixture is stirred until uniform. The dimethicone is then ~191~753 WO 95/31978 PCTlUS95/04734 sss added and the mixture stirred for 5 minutes to fully disperse the silicone.
Next, the 5% NaOH solution is gradually added with continuous mixing.
The compositions is then mixed for 3-5 minutes until homogeneous.
The resulting anti-acne composition exhibits low skin irritation and good physical and chemical stability, and is useful for topical application to s4o human skin for the treatment of acne.

Anti-Acne Gel An antiacne gel is prepared by combining the following ingredients 84s using conventional mixing techniques.
In4redients Wei4ht Percent Water qs100 gso Benzoyl Peroxidel 10.00 Carbomer 9802 0.65 Disodium EDTA 0.10 Sodium Hydroxide 0.12 Bentonite 1.0 sss Dioctyl Sodium Sulfosuccinate 0.10 Dimethicone3 1.0 1 Lucidol~ 70 from Elf Atochem, which is a powder containing 70% benzoyl peroxide active. 14.29% percent of this powder is added to the composition 86o to account for the 70% activity.
2 Carbopol~-980 from B.F. Goodrich.
3 Dow Coming~ 200 Fluid (350 centistoke) from Dow Corning.
In a suitable vessel a benzoyl peroxide slurry is prepared by g6s combining the benzoyl peroxide with 17% of the water. This slurry is passed through a Colloid or Urschel mill to disperse the benzoyl peroxide, followed by rinsing the mill with approximately an additional 6% of the water, this rinse being added to the total slurry.
In a separate vessel a 5% sodium hydroxide solution is prepared s7o using 2.5% of the water.

In another vessel the carbomer 980 is gradually combined with the remaining water with agitation to disperse and hydrate the carbomer. The carbomer dispersion is then transferred to a vessel equipped with a high shear mixer (Day Mixer, Serial No. 88612, Day Mixing, Cincinnati, OH) for s7s blending the remaining ingredients. Next, the disodium EDTA is added and mixed until dissolved. The dioctyl sodium sulfosuccinate is then added and stirred until uniform. The bentonite is added to the mixture which is stirred with sufficient agitation until dispersed. Next, the benzoyl peroxide slurry is added and the mixture is stirred until uniform. The dimethicone is then gso added and the mixture stirred for 5 minutes to fully disperse the silicone.
Next, the 5% NaOH solution is gradually added with continuous mixing.
The compositions is then mixed for 3-5 minutes until homogeneous.
The resulting anti-acne composition exhibits low skin irritation and good physical and chemical stability, and is useful for topical application to s8s human skin for the treatment of acne.

Anti-Acne Gel An antiacne gel is prepared by combining the following ingredients g9o using conventional mixing techniques.
Ingredients Weight Percent Water qs100 s9s Benzoyl Peroxidel 2.50 Carbomer 9802 0.65 Disodium EDTA 0.10 Sodium Hydroxide 0.12 Bentonite 1.0 90o Dimethicone Copolyol3 0.10 Cyclomethicone (and) Dimethiconol4 3.0 1 Lucidol~ 70 from Elf Atochem, which is a powder containing 70°~
benzoyl peroxide active. 3.57% percent of this powder is added to the composition 9os to account for the 70% activity.
2 Carbopol~ 980 from B. F. Goodrich.
3 Dow Coming~ 193 from Dow Corning.

WO 95/31978 Z 19 07 53 pCT/U895104734 4 Dow Corning~ Q2-1401 Fluid from Dow Corning.
9io In a suitable vessel a benzoyl peroxide slurry is prepared by combining the benzoyl peroxide with 17% of the water. This slurry is passed through a Colloid or Urschel mill to disperse the benzoyl peroxide, followed by rinsing the mill with approximately an additional 6°h of the water, this rinse being added to the total slurry.
9is In a separate vessel a 5% sodium hydroxide solution is prepared using 2.5% of the water.
In another vessel the carbomer 980 is gradually combined with the remaining water with agitation to disperse and hydrate the carbomer. The carbomer dispersion is then transferred to a vessel equipped with a high 92o shear mixer (Day Mixer, Serial No. 88612, Day Mixing, Cincinnati, OH) for blending the remaining ingredients. Next, the disodium EDTA is added and mixed until dissolved. The dimethicone copolyol is then added and stirred until uniform. The bentonite is added to the mixture which is stirred with sufficient agitation until dispersed. Next, the benzoyl peroxide slung is 92s added and the mixture is stirred until uniform. The cyclomethicone (and) dimethiconol is then added and the mixture stirred for 5 minutes to fully disperse the silicone. Next, the 5% NaOH solution is gradually added with continuous mixing. The compositions is then mixed for 3-5 minutes until homogeneous.
93o The resulting anti-acne composition exhibits tow skin irritation and good physical and chemical stability, and is useful for topical application to human skin for the treatment of acne.
WHAT IS CLAIMED IS:

Claims (24)

1. An anti-acne composition comprising:
(a) from about 0.1 % to about 20% benzoyl peroxide, (b) from about 0.01 % to about 10% of a wetting agent, (c) from about 20% to about 99.74% water, (d) from about 0.1 % to about 10% of a non-volatile emollient component which is a liquid at 25°C and which has a weighted arithmetic mean solubility parameter of less than or equal to about 7, and (e) from about 0.05% to about 5% of a water soluble or dispersible gelling agent.
2. A composition according to Claim 1 comprising from about 0.5% to about 15% benzoyl peroxide.
3. A composition according to Claim 1 comprising from about 2.5% to about 10% benzoyl peroxide.
4. A composition according to Claim 3 wherein said wetting agent is a dimethicone copolyol corresponding to the chemical formula (CH3)3SiO[(CH3)2SiO]x[(CH3)RSiO]y Si(CH3)g wherein R is C3H5O(C2H4O m(C3H6O)n H, x is an integer from 1 to about 500, y is an integer from about 1 to about 500, x is an integer from about 1 to about 250, and y is an integer from about 1 to about 250.
5. A composition according to Claim 3 wherein said wetting agent is selected from the group consisting of dioctyl sodium sulfosuccinate, sodium lauraminodipropionate, caprylyl pyrollidone, dimethyl octynediol, tetramethyl decynediol, and mixtures thereof.
6. A composition according to Claim 3 wherein said wetting agent is dioctyl sodium sulfosuccinate.
7. A composition according to Claim 4 wherein said emollient component is selected from the group consisting of silicones, hydrocarbons, esters, and mixtures thereof.
8. A composition according to Claim 7 wherein said emollient is a silicone selected from the group consisting of polyalkylsiloxanes, cyclic polyalkylsiloxanes, polyalkylarylsiloxanes, and mixtures thereof.
9. A composition according to Claim 8 wherein said emollient is a polyalkylsiloxane corresponding to the chemical formula R3SiO[R2SiO]x SiR3 wherein R is an alkyl group selected from methyl or ethyl and x is an integer from 0 to about 500.
10. A composition according to Claim 9 wherein R in said polyalkylsiloxane is methyl.
11. A composition according to Claim 8 wherein said emollient is a cyclic polyalkylsiloxane corresponding to the chemical formula [SiR2-O]n wherein R is an alkyl group selected from methyl or ethyl, and n is an integer from about 3 to about 7.
12. A composition according to Claim 8 wherein said emollient is a hydrocarbon selected from the group consisting of dodecane, squalane, cholesterol, hydrogenated polyisobutylene, docosane, hexadecane, isohexadecane, paraffins, mineral oil, and mixtures thereof.
13. A composition according to Claim 8 wherein said emollient is an ester selected from the group consisting of diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, 2-ethylhexyl palmitate, isodecyl neopentanoate, C12-15 alcohols benzoate, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenrate, and mixtures thereof.
14. A composition according to Claim 9 wherein said water soluble or dispersible gelling agent is selected from the group consisting of carboxylic acid polymers, crosslinked polyacrylate polymers, polacrylamide polymers, polysaccharides, gums, crosslinked ether/maleic anhydride copolymers, cellulosic thickeners, crosslinked poly(N-vinylpyrrolidones), and mixtures thereof.
15. A composition according to Claim 14 wherein said gelling agent is a carboxylic acid polymer selected from the group consisting of carbomers, acrylates/C 10-alkyl acrylate cross polymers, and mixtures thereof.
16. A composition according to Claim 15 wherein said benzoyl peroxide has an average particle size diameter from about 0.5 to about 40 microns.
17. A use of an anti-acne effective amount of the composition of Claim 1 for the treatment of acne in a human in need thereof.
18. A use of an anti-acne effective amount of the composition of Claim 4 for the treatment of acne in a human in need thereof.
19. A use of an anti-acne effective amount of the composition of Claim 7 for the treatment of acne in a human in need thereof.
20. A use of an anti-acne effective amount of the composition of Claim 15 for the treatment of acne in a human in need thereof.
21. A use of an anti-acne effective amount of the composition of Claim 1 for the production of a medicament for the treatment of acne in a human in need thereof.
22. A use of an anti-acne effective amount of the composition of Claim 4 for the production of a medicament for the treatment of acne in a human in need thereof.
23. A use of an anti-acne effective amount of the composition of Claim 7 for the production of a medicament for the treatment of acne in a human in need thereof.
24. A use of an anti-acne effective amount of the composition of Claim 15 for the production of a medicament for the treatment of acne in a human in need thereof.
CA002190753A 1994-05-19 1995-04-19 Anti-acne compositions Expired - Lifetime CA2190753C (en)

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US08/245,777 1994-05-19
US08/245,777 US5470884A (en) 1994-05-19 1994-05-19 Anti-acne compositions
PCT/US1995/004734 WO1995031978A1 (en) 1994-05-19 1995-04-19 Anti-acne compositions

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WO1995031978A1 (en) 1995-11-30
CN1079669C (en) 2002-02-27
CN1148808A (en) 1997-04-30
ES2224125T3 (en) 2005-03-01
EP0759749B1 (en) 2004-07-07
CA2190753A1 (en) 1995-11-30
DE69533239T2 (en) 2005-08-18
US5470884A (en) 1995-11-28
DE69533239D1 (en) 2004-08-12
EP0759749A1 (en) 1997-03-05
ATE270546T1 (en) 2004-07-15

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