CA2194976A1 - Wound healing agent - Google Patents

Wound healing agent

Info

Publication number
CA2194976A1
CA2194976A1 CA002194976A CA2194976A CA2194976A1 CA 2194976 A1 CA2194976 A1 CA 2194976A1 CA 002194976 A CA002194976 A CA 002194976A CA 2194976 A CA2194976 A CA 2194976A CA 2194976 A1 CA2194976 A1 CA 2194976A1
Authority
CA
Canada
Prior art keywords
wound healing
healing agent
chitosan
polysaccharide
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002194976A
Other languages
French (fr)
Other versions
CA2194976C (en
Inventor
Ibrahim Gouda
Olle Larm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicarb AB
Original Assignee
Ibrahim Gouda
Olle Larm
Medicarb Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ibrahim Gouda, Olle Larm, Medicarb Ab filed Critical Ibrahim Gouda
Publication of CA2194976A1 publication Critical patent/CA2194976A1/en
Application granted granted Critical
Publication of CA2194976C publication Critical patent/CA2194976C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The use of chitosan in combination with a first polysaccharide selected from heparin, heparan sulphate and dextran sulphate for the manufacture of an agent that accelerates, stimulates and/or promotes healing of dermal wounds, said polysaccharide, optionally, being immobilized to the chitosan; and a process for the treatment of dermal wounds.
CA002194976A 1994-07-19 1995-07-18 Wound healing agent Expired - Fee Related CA2194976C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9402531-9 1994-07-19
SE9402531A SE9402531L (en) 1994-07-19 1994-07-19 wound healing agent
PCT/SE1995/000875 WO1996002260A1 (en) 1994-07-19 1995-07-18 Wound healing agent

Publications (2)

Publication Number Publication Date
CA2194976A1 true CA2194976A1 (en) 1996-02-01
CA2194976C CA2194976C (en) 2002-04-30

Family

ID=20394771

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194976A Expired - Fee Related CA2194976C (en) 1994-07-19 1995-07-18 Wound healing agent

Country Status (11)

Country Link
US (1) US5902798A (en)
EP (1) EP0759760B1 (en)
JP (1) JP3337472B2 (en)
AT (1) ATE207753T1 (en)
AU (1) AU691322B2 (en)
CA (1) CA2194976C (en)
DE (1) DE69523585T2 (en)
DK (1) DK0759760T3 (en)
ES (1) ES2161903T3 (en)
SE (1) SE9402531L (en)
WO (1) WO1996002260A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576839A (en) * 1991-09-25 1996-11-19 Minolta Camera Kabushiki Kaisha Camera system including a separatable recorder
SE508760C2 (en) * 1997-04-29 1998-11-02 Medicarb Ab Use of a composition comprising chitosan in combination with a polysaccharide, as an active component in a solvent, for the preparation of a dairy dipping agent for milk producing animals
NL1011680C2 (en) 1999-03-26 2000-09-27 Nutricia Nv Food compositions containing lightly negatively charged, non-digestible polysaccharides and use thereof to reduce transport through tight junctions.
US6391334B1 (en) 1999-10-25 2002-05-21 Amway Corporation Barrier-forming composition
CA2685349C (en) * 1999-11-15 2013-09-17 Bio Syntech Canada Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
ATE247495T1 (en) * 1999-12-09 2003-09-15 Biosyntech Canada Inc MINERAL-POLYMER HYBRID COMPOSITION
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
GB9929472D0 (en) * 1999-12-13 2000-02-09 Btg Int Ltd Polymeric film
IL153490A0 (en) * 2000-06-29 2003-07-06 Biosyntech Canada Inc Composition and method for the repair and regeneration of cartilage and other tissues
DE60125973D1 (en) * 2000-11-15 2007-02-22 Biosyntech Canada Inc METHOD FOR RECOVERING A DAMAGED BAND DISC
US6623761B2 (en) 2000-12-22 2003-09-23 Hassan Emadeldin M. Method of making nanoparticles of substantially water insoluble materials
KR20020066024A (en) * 2001-02-08 2002-08-14 굿젠 주식회사 An ointment composition and film comprising aqueous chitosan and heparin, and wound management products
SE522529C2 (en) 2001-04-12 2004-02-17 Medicarb Ab Effervescent solid composition used for treating dermal wounds comprises chitosan or component releasing carbon dioxide in acidic environment
BR0208858A (en) * 2001-04-12 2004-10-19 Medicarb Ab Effervescent solid matter composition, use thereof, method for treating a mammal suffering from a dermal wound, for treating wound healing of a lactating animal suffering from mastitis and for prophylactic treatment of a lactating animal prone to developing mastitis.
US7297343B2 (en) * 2001-07-31 2007-11-20 Biosurface Engineering Technologies, Inc. Bioactive medical films
KR20020060627A (en) * 2002-01-16 2002-07-18 조석형 Wound Healing of chitosan/anionic polysaccharides complex
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
JP5614913B2 (en) * 2002-07-16 2014-10-29 ピラマル ヘルスケア （カナダ） リミテッド Composition of a cytocompatible, injectable and self-gelling chitosan solution for encapsulating and delivering live cells or biologically active factors
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US20070053848A1 (en) * 2003-08-26 2007-03-08 Stockel Richard F Antimicrobial materials for dental care applications
JP2006347883A (en) * 2003-09-08 2006-12-28 Neetec:Kk Composition for medical treatment comprising sugar chain-containing chitosan derivative and glycosaminoglycan
ES2380340T3 (en) 2003-12-05 2012-05-10 Northwestern University Self-assembling peptide amphiphiles and related methods for the administration of growth factors
US20070086977A1 (en) * 2003-12-22 2007-04-19 Stockel Richard F Method of treating dermatological conditions
US20050136024A1 (en) * 2003-12-22 2005-06-23 Stockel Richard F. Dermatological compositions
US20050283004A1 (en) * 2004-06-18 2005-12-22 Hopax Chemicals Manufacturing Co., Ltd. Alkylsulfonated polyaminosaccharides
MX2007010771A (en) * 2005-03-04 2008-03-10 Univ Northwestern Angiogenic heparin binding peptide amphiphiles.
US20090149421A1 (en) * 2005-11-04 2009-06-11 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
DE102006020035A1 (en) * 2006-04-26 2007-10-31 B. Braun Melsungen Ag Preparation and use of poly (hydroxyethyl starch) chitin and poly (carboxymethyl starch) chitin compounds
EP1958613A1 (en) * 2007-02-15 2008-08-20 Polichem S.A. Dermal film-forming liquid formulations for drug release to skin
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
CN104874007A (en) 2007-08-28 2015-09-02 奥塔哥创新有限公司 Surgical Hydrogel
PL2346573T3 (en) * 2008-11-20 2014-12-31 Laboratori Derivati Organici S P A Use of heparan sulfate in cosmetological and dermatological preparations
US9011920B2 (en) 2008-12-06 2015-04-21 B. Braun Melsungen Ag Transport-mediating colloidal pharmaceutical compounds
CA2755829C (en) 2009-03-31 2016-06-07 B. Braun Melsungen Ag Bonding products of aminated polysaccharides
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use
JP2012529506A (en) * 2009-06-10 2012-11-22 エーエクスセラ アクチエボラグ Use of a composition for treatment of mucositis
WO2011026498A1 (en) 2009-09-01 2011-03-10 Medovent Gmbh Chitosan tissue dressing
EP2542246A1 (en) * 2010-03-03 2013-01-09 Neocutis SA Compositions and methods for treatment of skin diseases and disorders using antimicrobial peptide sequestering compounds
JP6437916B2 (en) 2013-08-13 2018-12-12 生化学工業株式会社 Medicine containing cationized chitosan
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
FR3016882A1 (en) 2014-01-30 2015-07-31 Sofradim Production PROCESS FOR THE PREPARATION OF HIGH-DEGREE ACETYLATION CHITOSAN
US10126298B2 (en) 2015-05-04 2018-11-13 Arman Nabatian Hydrogels containing embedded substrates for targeted binding of molecules
US9248160B1 (en) 2015-07-28 2016-02-02 Zo Skin Health, Inc. Post-procedure skin care systems, compositions, and methods of use thereof
EP4218844A1 (en) 2018-01-12 2023-08-02 Boston Scientific Scimed, Inc. Powder for achieving hemostasis
EP3787593A1 (en) 2018-05-04 2021-03-10 Bonoss Medical Aktiebolag A composition for reduction of scar formation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378017A (en) * 1980-03-21 1983-03-29 Kureha Kagaku Kogyo Kabushiki Kaisha Composite material of de-N-acetylated chitin and fibrous collagen
US4326532A (en) * 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
CA1202904A (en) * 1983-11-21 1986-04-08 Brian G. Sparkes Chitosan based wound dressing materials
JPS61253065A (en) * 1985-05-02 1986-11-10 片倉チツカリン株式会社 Medical composite material of chitosan derivative and collagen and its production
US5037810A (en) * 1987-03-17 1991-08-06 Saliba Jr Michael J Medical application for heparin and related molecules
US4879282A (en) * 1987-03-17 1989-11-07 Saliba Jr Michael J Medical application for heparin and related molecules
DE4200080A1 (en) * 1992-01-03 1993-09-30 Reinmueller Johannes Pharmaceutical composition for wound, scar and keloid treatment
JP3205104B2 (en) * 1992-01-20 2001-09-04 川研ファインケミカル株式会社 Cosmetics
SE9402529D0 (en) * 1994-07-19 1994-07-19 Astra Ab Anti-adherents

Also Published As

Publication number Publication date
SE9402531D0 (en) 1994-07-19
SE9402531L (en) 1996-01-20
JPH10502665A (en) 1998-03-10
EP0759760B1 (en) 2001-10-31
ATE207753T1 (en) 2001-11-15
CA2194976C (en) 2002-04-30
DK0759760T3 (en) 2001-11-26
AU3090295A (en) 1996-02-16
JP3337472B2 (en) 2002-10-21
US5902798A (en) 1999-05-11
AU691322B2 (en) 1998-05-14
ES2161903T3 (en) 2001-12-16
DE69523585D1 (en) 2001-12-06
EP0759760A1 (en) 1997-03-05
DE69523585T2 (en) 2002-04-11
WO1996002260A1 (en) 1996-02-01

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20150720