CA2197000A1 - Surface-modifying copolymers having cell adhesion properties - Google Patents

Surface-modifying copolymers having cell adhesion properties

Info

Publication number
CA2197000A1
CA2197000A1 CA002197000A CA2197000A CA2197000A1 CA 2197000 A1 CA2197000 A1 CA 2197000A1 CA 002197000 A CA002197000 A CA 002197000A CA 2197000 A CA2197000 A CA 2197000A CA 2197000 A1 CA2197000 A1 CA 2197000A1
Authority
CA
Canada
Prior art keywords
gly
asp
arg
polyurethane
modifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002197000A
Other languages
French (fr)
Other versions
CA2197000C (en
Inventor
Judy S. Riffle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thoratec LLC
Original Assignee
Judy S. Riffle
Thoratec Laboratories Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Judy S. Riffle, Thoratec Laboratories Corporation filed Critical Judy S. Riffle
Publication of CA2197000A1 publication Critical patent/CA2197000A1/en
Application granted granted Critical
Publication of CA2197000C publication Critical patent/CA2197000C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/458—Block-or graft-polymers containing polysiloxane sequences containing polyurethane sequences

Abstract

A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane-urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative block which is miscible with the poly(urethane) or poly(urethane-urea) base polymer, a polysiloxane hydrophobic soft block, an optional hydrophilic spacer and a peptide selected from the group consisting of Arg-Gly-Asp, X-Arg-Gly-Asp, Arg-Gly-Asp-X and X-Arg-Gly-Asp-X', wherein X and X' are amino acids.
CA002197000A 1995-06-07 1996-05-22 Surface-modifying copolymers having cell adhesion properties Expired - Fee Related CA2197000C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/487,604 1995-06-07
US08/487,604 US5733538A (en) 1995-06-07 1995-06-07 Surface-modifying copolymers having cell adhesion properties
PCT/US1996/007500 WO1996040187A1 (en) 1995-06-07 1996-05-22 Surface-modifying copolymers having cell adhesion properties

Publications (2)

Publication Number Publication Date
CA2197000A1 true CA2197000A1 (en) 1996-12-19
CA2197000C CA2197000C (en) 2003-10-21

Family

ID=23936420

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002197000A Expired - Fee Related CA2197000C (en) 1995-06-07 1996-05-22 Surface-modifying copolymers having cell adhesion properties

Country Status (8)

Country Link
US (1) US5733538A (en)
EP (1) EP0779815B1 (en)
JP (1) JP2001516228A (en)
AU (1) AU5802596A (en)
CA (1) CA2197000C (en)
DE (1) DE69612267T2 (en)
ES (1) ES2155188T3 (en)
WO (1) WO1996040187A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG66458A1 (en) * 1997-05-15 1999-07-20 Givaudan Roure Int Fragrance precursor compounds
US6548263B1 (en) 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6136872A (en) * 1998-11-20 2000-10-24 Shell Oil Company Freeze-dried polystyrene-polysiloxane foams
AUPQ100699A0 (en) 1999-06-17 1999-07-08 Northern Sydney Area Health Service An assist device for the failing heart
US6403063B1 (en) 1999-07-26 2002-06-11 Kenneth I. Sawyer Method of treating nail fungus
KR100312178B1 (en) * 1999-10-06 2001-11-03 서경배 the new amino acid silicon polymers, the method for producing them, the amino acid silicon polymer-suface treated cosmetic particles, and the cosmetic composition including the above particles
AU2001294671A1 (en) 2000-09-25 2002-04-08 The Board Of Trustees Of The University Of Illinois Microfabrication of membranes for the growth of cells
AUPR333301A0 (en) * 2001-02-23 2001-03-22 Northern Sydney Area Health Service Determining the volume of a normal heart and its pathological and treated variants by using dimension sensors
US6783709B2 (en) * 2002-07-10 2004-08-31 The Regents Of The University Of California Self-healing organosiloxane materials containing reversible and energy-dispersive crosslinking domains
ATE459380T1 (en) * 2002-08-13 2010-03-15 Medtronic Inc DOSAGE SYSTEMS OF ACTIVE INGREDIENTS WITH POLY(ETHYLENE-CO(METH)ACRYLATES, MEDICAL DEVICE AND METHOD
CA2494188A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivative
AU2003258209A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
US20040033251A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a polyurethane, medical device, and method
AU2003265446A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
DE60333566D1 (en) * 2002-08-13 2010-09-09 Medtronic Inc MEDICAL DEVICE WITH IMPROVED LIABILITY BETWEEN A POLYMERIC TOUCH AND A SUBSTRATE
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
CA2535345A1 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
US20050095218A1 (en) * 2003-10-29 2005-05-05 The Procter & Gamble Company Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants
WO2005112974A2 (en) * 2004-05-14 2005-12-01 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US8084275B2 (en) * 2005-02-08 2011-12-27 Fujifilm Corporation Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface
JP2007040978A (en) * 2005-06-30 2007-02-15 Fujifilm Corp Method for separating objective element using magnetic nanoparticles
EP2213293A3 (en) * 2005-12-08 2011-09-28 The Polymer Technology Group Incorporated Self-assembling monomers and oligomers as surface-modifying endgroups for polymers
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
JP5062820B2 (en) * 2007-03-23 2012-10-31 株式会社Ａｄｅｋａ Cyclic siloxane compound and positive resist composition using the same
US9994812B2 (en) 2012-04-04 2018-06-12 University Of Washington Through Its Center For Commercialization Systems and method for engineering muscle tissue
WO2014065017A1 (en) * 2012-10-26 2014-05-01 独立行政法人国立循環器病研究センター Artificial blood vessel, and method for producing artificial blood vessel

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689383A (en) * 1986-03-18 1987-08-25 Thoratec Laboratories Corp. Hydroxyl-functional disiloxanes and polysiloxane oligomers
US5079600A (en) * 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US4789601A (en) * 1987-05-04 1988-12-06 Banes Albert J Biocompatible polyorganosiloxane composition for cell culture apparatus
US4839280A (en) * 1987-05-04 1989-06-13 Banes Albert J Apparatus for applying stress to cell cultures
US4822741A (en) * 1987-05-04 1989-04-18 Banes Albert J Biocompatible polyorganosiloxane composition for cell culture apparatus
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5369012A (en) * 1992-03-26 1994-11-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals

Also Published As

Publication number Publication date
DE69612267D1 (en) 2001-05-03
JP2001516228A (en) 2001-09-25
EP0779815A4 (en) 1998-06-03
EP0779815B1 (en) 2001-03-28
WO1996040187A1 (en) 1996-12-19
DE69612267T2 (en) 2001-07-05
ES2155188T3 (en) 2001-05-01
AU5802596A (en) 1996-12-30
EP0779815A1 (en) 1997-06-25
CA2197000C (en) 2003-10-21
US5733538A (en) 1998-03-31

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Legal Events

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MKLA Lapsed

Effective date: 20130522