CA2208051A1 - Systems and method for removing free and entrained contaminants in plasma - Google Patents
Systems and method for removing free and entrained contaminants in plasmaInfo
- Publication number
- CA2208051A1 CA2208051A1 CA002208051A CA2208051A CA2208051A1 CA 2208051 A1 CA2208051 A1 CA 2208051A1 CA 002208051 A CA002208051 A CA 002208051A CA 2208051 A CA2208051 A CA 2208051A CA 2208051 A1 CA2208051 A1 CA 2208051A1
- Authority
- CA
- Canada
- Prior art keywords
- plasma
- systems
- leukocytes
- contaminants
- removing free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
Abstract
Systems and methods treat plasma carrying contaminants and leukocytes that are capable of entraining contaminants. The systems and methods separate leukocytes from the plasma by filtration, thereby removing contaminants entrained within leukocytes. The systems and methods also add to the plasma a photoactive material and emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by leukocytes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/574,741 US5935092A (en) | 1990-12-20 | 1995-12-19 | Systems and methods for removing free and entrained contaminants in plasma |
US08/574,741 | 1995-12-19 | ||
PCT/US1996/018875 WO1997022245A1 (en) | 1995-12-19 | 1996-11-26 | Systems and methods for removing free and entrained contaminants in plasma |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2208051A1 true CA2208051A1 (en) | 1997-06-26 |
CA2208051C CA2208051C (en) | 2005-04-12 |
Family
ID=24297431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002208051A Expired - Lifetime CA2208051C (en) | 1995-12-19 | 1996-11-26 | Systems and method for removing free and entrained contaminants in plasma |
Country Status (8)
Country | Link |
---|---|
US (2) | US5935092A (en) |
EP (1) | EP0809433B1 (en) |
JP (1) | JP4239114B2 (en) |
AT (1) | ATE276655T1 (en) |
CA (1) | CA2208051C (en) |
DE (1) | DE69633439T2 (en) |
NO (1) | NO316989B1 (en) |
WO (1) | WO1997022245A1 (en) |
Families Citing this family (37)
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---|---|---|---|---|
US5935092A (en) * | 1990-12-20 | 1999-08-10 | Baxter International Inc. | Systems and methods for removing free and entrained contaminants in plasma |
US6168718B1 (en) | 1996-11-08 | 2001-01-02 | Pall Corporation | Method for purifying blood plasma and apparatus suitable therefor |
US6197207B1 (en) * | 1997-05-21 | 2001-03-06 | Baxter International Inc. | Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products |
DE29801590U1 (en) * | 1998-01-30 | 1998-04-16 | Maco Pharma Int Gmbh | Blood bag system for virus inactivation of blood, blood components and plasma |
FR2774293B1 (en) * | 1998-02-05 | 2000-08-11 | Maco Pharma Sa | PLASMA TRANSFORMATION PROCESS AND DEVICE FOR IMPLEMENTING SAME |
US6669905B1 (en) * | 1998-05-21 | 2003-12-30 | Baxter International Inc. | Systems and methods for collecting plasma that is free or virtually free of cellular blood species |
US6277337B1 (en) | 1998-07-21 | 2001-08-21 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
DE19914850A1 (en) * | 1999-04-01 | 2000-10-05 | Gerhard Saalmann | Device for inactivating viruses, especially human immunodeficiency virus (HIV) from blood products, uses coloring agents and radiation |
US7445756B2 (en) * | 1999-06-03 | 2008-11-04 | Fenwal, Inc. | Fluid processing sets and organizers for the same |
US7025877B1 (en) * | 1999-06-03 | 2006-04-11 | Baxter International Inc. | Processing set for processing and treating a biological fluid |
US7068361B2 (en) * | 1999-06-03 | 2006-06-27 | Baxter International | Apparatus, systems and methods for processing and treating a biological fluid with light |
US6565802B1 (en) * | 1999-06-03 | 2003-05-20 | Baxter International Inc. | Apparatus, systems and methods for processing and treating a biological fluid with light |
DE19938287A1 (en) * | 1999-08-12 | 2001-03-15 | Fresenius Ag | Device and method for autologous transfusion of blood |
JP2003509124A (en) * | 1999-09-16 | 2003-03-11 | バソジェン アイルランド リミテッド | Apparatus and process for conditioning mammalian blood |
US6268120B1 (en) | 1999-10-19 | 2001-07-31 | Gambro, Inc. | Isoalloxazine derivatives to neutralize biological contaminants |
CN1420796A (en) * | 2000-03-31 | 2003-05-28 | 巴克斯特国际公司 | Systems and methods for collecting leukocyte-reduced blood components, including plasma that is free or virtually free of cellular blood species |
US7648699B2 (en) | 2000-06-02 | 2010-01-19 | Caridianbct Biotechnologies, Llc | Preventing transfusion related complications in a recipient of a blood transfusion |
TW590780B (en) | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
US7985588B2 (en) | 2000-06-02 | 2011-07-26 | Caridianbct Biotechnologies, Llc | Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light |
US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
US7264608B2 (en) | 2001-12-05 | 2007-09-04 | Fenwal, Inc. | Manual processing systems and methods for providing blood components conditioned for pathogen inactivation |
WO2004035066A1 (en) * | 2002-10-16 | 2004-04-29 | Asahi Kasei Pharma Corporation | Plasma preparation or serum preparation and process for producing the same |
US8808977B2 (en) * | 2003-05-22 | 2014-08-19 | Beijing Jingjing Medical Equipment Co., Ltd | Method of inactivating virus in circular blood and its applications in treating viral diseases |
FR2857987B1 (en) * | 2003-07-21 | 2005-10-07 | Staubli Sa Ets | FRAME OF LISSES AND WEAVING EQUIPPED WITH AT LEAST ONE SUCH FRAMEWORK |
US20050137517A1 (en) * | 2003-12-19 | 2005-06-23 | Baxter International Inc. | Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation |
DE102006014184A1 (en) * | 2006-03-24 | 2007-09-27 | Heim, Heidrun | Deactivating unwanted organisms in blood plasma, especially viruses, involves adding porphyrin to blood plasma immediately after extracting it from blood and irradiating mixture with xenon radiation |
US7938454B2 (en) | 2007-04-24 | 2011-05-10 | Hyclone Laboratories, Inc. | Sterile connector systems |
CN101668558B (en) * | 2007-04-24 | 2013-01-23 | 海克隆实验室有限公司 | Sterile connector systems |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
JP2014518547A (en) | 2011-04-07 | 2014-07-31 | フェンウォール、インコーポレイテッド | Automated method and system for providing platelet concentrates with reduced residual plasma volume and storage medium for such platelet concentrates |
CN103861325A (en) * | 2012-12-18 | 2014-06-18 | 苏州排头兵药业科技有限公司 | Platelet separator and platelet concentration device |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
TR201910227A2 (en) * | 2019-07-09 | 2019-07-22 | Gazi Enduestri Anonim Sirketi | METHOD OF OBTAINING SOLID PLASMA AS A FILLING MATERIAL |
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US3876738A (en) | 1973-07-18 | 1975-04-08 | Amf Inc | Process for producing microporous films and products |
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EP0155003B1 (en) | 1984-03-15 | 1990-07-04 | ASAHI MEDICAL Co., Ltd. | Filtering unit for removing leukocytes |
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US5229012A (en) * | 1989-05-09 | 1993-07-20 | Pall Corporation | Method for depletion of the leucocyte content of blood and blood components |
DE69005354D1 (en) * | 1989-05-09 | 1994-02-03 | Pall Corp | Device and method for reducing the leukocyte content of blood and blood components. |
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US5935092A (en) * | 1990-12-20 | 1999-08-10 | Baxter International Inc. | Systems and methods for removing free and entrained contaminants in plasma |
EP0516836B1 (en) * | 1990-12-20 | 1996-03-13 | Baxter International Inc. | A device and method for eradicating contaminants in fluids |
US5498336A (en) * | 1991-02-22 | 1996-03-12 | Terumo Kabushiki Kaisha | Leukocyte-removing filter and leukocyte-removing apparatus furnished therewith |
JP3124565B2 (en) * | 1991-02-22 | 2001-01-15 | テルモ株式会社 | Leukocyte removal filter and leukocyte removal device |
WO1992019355A1 (en) * | 1991-05-08 | 1992-11-12 | Baxter International Inc. | Methods for processing red blood cell products for long term storage free of microorganisms |
CA2074671A1 (en) | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
US5549834A (en) * | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
JP3383962B2 (en) * | 1992-02-28 | 2003-03-10 | ニプロ株式会社 | Leukocyte removal filter |
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JP3311091B2 (en) | 1993-06-27 | 2002-08-05 | テルモ株式会社 | Filter for separating white blood cells and filter for separating white blood cells and platelets |
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US5639376A (en) | 1994-01-10 | 1997-06-17 | Hemasure, Inc. | Process for simultaneously removing leukocytes and methylene blue from plasma |
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US6190855B1 (en) * | 1996-10-28 | 2001-02-20 | Baxter International Inc. | Systems and methods for removing viral agents from blood |
-
1995
- 1995-12-19 US US08/574,741 patent/US5935092A/en not_active Expired - Lifetime
-
1996
- 1996-11-26 DE DE69633439T patent/DE69633439T2/en not_active Expired - Lifetime
- 1996-11-26 JP JP52281097A patent/JP4239114B2/en not_active Expired - Lifetime
- 1996-11-26 EP EP96941472A patent/EP0809433B1/en not_active Expired - Lifetime
- 1996-11-26 WO PCT/US1996/018875 patent/WO1997022245A1/en active IP Right Grant
- 1996-11-26 AT AT96941472T patent/ATE276655T1/en not_active IP Right Cessation
- 1996-11-26 CA CA002208051A patent/CA2208051C/en not_active Expired - Lifetime
-
1997
- 1997-08-18 NO NO19973790A patent/NO316989B1/en not_active IP Right Cessation
-
1998
- 1998-05-05 US US09/073,230 patent/US6695805B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO973790D0 (en) | 1997-08-18 |
EP0809433A1 (en) | 1997-12-03 |
EP0809433A4 (en) | 2001-01-10 |
DE69633439T2 (en) | 2005-09-22 |
US6695805B1 (en) | 2004-02-24 |
ATE276655T1 (en) | 2004-10-15 |
JPH11505269A (en) | 1999-05-18 |
JP4239114B2 (en) | 2009-03-18 |
WO1997022245A1 (en) | 1997-06-26 |
CA2208051C (en) | 2005-04-12 |
NO973790L (en) | 1997-10-17 |
US5935092A (en) | 1999-08-10 |
DE69633439D1 (en) | 2004-10-28 |
NO316989B1 (en) | 2004-07-19 |
EP0809433B1 (en) | 2004-09-22 |
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