CA2214195A1 - Medication delivery pen having a 31 gauge needle - Google Patents
Medication delivery pen having a 31 gauge needle Download PDFInfo
- Publication number
- CA2214195A1 CA2214195A1 CA002214195A CA2214195A CA2214195A1 CA 2214195 A1 CA2214195 A1 CA 2214195A1 CA 002214195 A CA002214195 A CA 002214195A CA 2214195 A CA2214195 A CA 2214195A CA 2214195 A1 CA2214195 A1 CA 2214195A1
- Authority
- CA
- Canada
- Prior art keywords
- gauge needle
- medication delivery
- delivery pen
- assembly
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/348—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly
Abstract
A needle assembly for a medication delivery pen having a 31 gauge needle cannulathat reduces penetration force during an injection process resulting in less pain to the patient without causing any loss in performance or structural integrity.
Description
~3DICATION DELIVERY PEN ELA.VING A. 3I GA.IJGE NEEDLE
. . .
BACKG~OUND OF TE~ ~VENTION
1. Field ofthe Invention.
The subject irivention relates to a medication delivery pen having a 31 gauge needle.
. . .
BACKG~OUND OF TE~ ~VENTION
1. Field ofthe Invention.
The subject irivention relates to a medication delivery pen having a 31 gauge needle.
2. ~ack~round Description.
Medication delivery pens are hypodermic syringes used for self-injection of precisely measured doses of medication. Pens are widely used, for example, by diabetics to dispense insulin.
.
A typical prior art medication delivery pen includes a cartridge which contains a volume of liquid medication sufficient for several doses. The cartridge ;n~ ld~s an elongated generally tubular glass cartridge having a pierceable rubber septum which extends across the open distal end of the car~lidge and ~ securely heId in position by a .. . ..
.
.
metallic sleeve that is crimped to the distal end of the cartridge. The cartridge also includes a rubber stopper in sliding fluid-tight engagement with interior walls of the cartridge.
Such a medication delivery pen also includes a unitarily molded cartridge retainer having a small diameter tubular neck dimensioned for tightly çn~ging the neck of the cartridge and the metallic sleeve crimped thereon so as to support and position the entire ~ cartridge. Exterior regions at the extreme distal end of the tubular neck are formed with an array of threads for threadedly receiving the mounting cap of a needle assembly. The medication delivery pen further includes a dosing al~pal~Lus that is engaged with the proximal end of the cartridge retainer having a plunger for ~ng~ging the rubber stopper of the cartridge. The dosing apparatus includes a dose setting structure used to select the longitudinal distance through which the plunger will move, and dispensing means for driving the plunger the selected distance.
The needle assembly for the medication delivery pen includes an elongate needle c~nn~ having opposed prox~,llal and distal points and a lumen e~t~nding therethrough.
A plastic cork is adhered to an intermediate position along the needle cannula and in turn is rigidly connected to an end wall of a cylindrical cap. The cylindrical wall of the cap surrounds the proximal point on the needle cannula and inc,l~ldes an array of internal threads for ~n~,~ing the external threads on the neck of the cartridge retainer.
The medication delivery pen may be used by urging the cap of the needle assemblyover the neck of the cartridge retainer sufficiently for the proximal point of the needle ~ nmll~ to pierce the rubber septum ofthe cartridge. The cap is then rotated to threadedly CA 0221419~ 1997-08-28 engage the neck of the cartridge retainer. The user then manipulates the dosing apparatus to select an appropriate dose. A protective shield over the distal end of the needle cannula is then removed, and the distal point of the needle cannula is injected. The user then actuates the dispensing means of the prior art dosing apparatus to urge the stopper of the 5 cartridge distally and to deliver medication through the lumen of the needle cannula. The needle is then withdrawn, and the needle assembly is separated from the cartridge retainer and safely discarded. The rubber septum of the cartridge reseals itself, and may be pierced ~ again for a subsequent ~(lmini~tration of medication. This process may be carried out repeatedly until all of the medication in the cartridge has been used.
A problem with currently available needle assemblies for use on medication delivery pens is the size of the c~nn~ Prior to the present invention, 27, 28, 29 and 30 gauge needle c~nn~ have been commonly used on medication delivery pens, with 30 gauge being the smallest diameter possible. Even though smaller gauges, i.e., 29 and 30 5 gauge, have helped to reduce pain to patients during injection, there is still a need to provide needle assemblies for medication delivery pens with smaller c~nnlll~ diameters since small diameter needles are perceived by patients to cause less pain during the injection. However, no one skilled in the art has suggested and no one has provided patients with needle assemblies having a diameter less than 30 gauge.
SUMMA~Y OF T~ INVENTION
The present invention overcomes the 30 gauge limit that has existed for pen needle assemblies by providing a 3 l gauge needle assembly for use on medication delivery pens.
2 5 The 3 l gauge needle provides a patient with a needle assembly having a smaller cannula , size without loss in per~ormance or structural integrity. The 3 l gauge needle assembly mounts on a needle mounting tip of a cartridge retainer assembly on a medication delivery pen and is used like prior art needle assemblies to pierce a patient's arm during an injection process.
However, since the 31 gauge needle cannula is smaller than prior art needle cannulas the penetration force is decreased which reduces the pain caused during an injection procedure. In addition, the smaller cannula size will be seen by the patient prior to the injection so that perceived pain or anticipated pain is also reduced. The reduction in 10 actual and perceived/anticipated pain provided by using the 3 l gauge needle on the medication delivery pen is a major benefit to patients that need numerous injections each day, i.e., diabetics requiring insulin injections.
These and other aspects, features and advantages of the present invention will 15 become apparent from the following detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRA~INGS
2 0 Fig. 1 is an exploded perspective view of a medication delively pen having a needle assembly in accordance with the subject invention; and Fig. 2 is a cross-sectional view of a cartridge retainer assembly of the medication delivery pen.
~ , , , DETAILl~P PESCRIPTIQN OF THE PREFERRED EM~C)l~)I~NT
A needle assembly for use on a medication delive~y pen 1 1, in accordance w~th the subject invention, is identified generally by the numeral 46 in Fig. l As shown in Fig. 1 5 medication delivery pen 11 includes a cartridge retainer assembly 10, a dosing apparatus 38 and a cartridge assembly 22. Needle assembly 46, as described in more detail below, is designed to be attached to a needle mounting insert tip 20 on cartridge retainer assembly Cartridge retainer assembly 10, as shown in Figs. 1 and 2, includes an elongate generally tubular body 12 with opposed proximal and distal ends 14 and 16, respectively.
A generally tubular needle mounting insert tip 20 is snap-fit mounted in distal end 16 of body 12 and cartridge retainer assembly 10 is dimensioned and configured to receive a cartridge assembly 22 therein.
Cartridge assembly 22 includes an open proximal end 26 and a distal end 25 defined by an inwardly converging shoulder 28. A small diameter neck 30 projects distally from shoulder 28 on cartridge assembly 22, and is provided with a large ~ met~r annular bead 24 e~n~ling circu,l~,e"Lially thereabout at the extreme distal end of neck 30. A
2 o pierceable and resealable rubber septum 32 extends completely across the open distal end defined by neck 30. Rubber septum 32 is held in place by a metallic sleeve 34 which is crimped around bead 24 at the distal end of neck 30. Medication such as insulin or heparin is pre-filled into cartridge assembly 22 and is retained therein by a rubber stopper 36. Stopper 36 is in sliding fluid-tight engagement with the tubular wall of cartridge assembly 22. Distally directed forces on stopper 36 urge the medication from pen 11 as explained further below.
Dosing ~Ippdlal~lS 38 in medication delivery pen 11 is generally cylindrical andincludes opposed proximal and distal ends 40 and 42, respectively. Threads 41 are S disposed at distal end 42 of dosing apparatus 38 for releasable threaded engagement with proximal end 14 of body 12 of cartridge retainer assembly 10. A plunger rod 44 projects distally from dosing apparatus 38 and is dimensioned to engage stopper 36 of cartridge assembly 22. Dosing apparatus 38 also includes known mech~ni.cm~ for setting a selected dose of medication to be delivered by pen 11. A dispensing mech~ni~m (not shown) is 10 operative to drive plunger rod 44 a selected distance in a distal direction for moving stopper 36 a distance that will inject the selected dose of medication from cartridge assembly 22. Although a particular prior art dosing apparatus 38 is depicted in Fig. 1, it is to be understood that other dosing apparatus can be used with the needle assembly of the subject invention.
Needle assembly 46, according to the present invention, includes a 31 gauge needle c~nnl71~ 48 with opposed ~ imal and distal tips 50 and 52, respectively, and a lumen 51 ~.~çn~lin~ entirely therethrough. The dimensions of 31 gauge needle cannula 48 are set forth below:
Parameter Value Outer Diameter 0.010"-0.0105"
Inner Diameter 0.0045"-0.006"
Wall Thickness0.00225"-0.00275"
Usablelength 0.315" (8mm) CA 0221419~ 1997-08-28 Cannula ~laterial Stainless Steel Of course, 31 gauge needle cannulas of other lengths can also be used, i.e., 0.236" (6mm) or 0.394" (I Omm), and still remain within the scope of the present invention. A cork 54 is securely affixed at an intermediate position along needle cannula 48, and a cap 56 is securely affixed to cork 54. Cap 56 of needle assembly 46 includes an array of internal threads (not shown) for removable mounting needle assembly 46 to needle mounting inse~t tip 20 on cartridge retainer assembly 10. It is to be understood, however, that other releasable engagement means between needle assembly 46 and cartridge retainer assembly 10 can be provided. For example, external threads can be formed on needle assembly 46 lo and corresponding internal threads can be defined on cartridge retainer assembly 10 or a bayonet style mounting using lugs and slots can be used. In addition, needle assembly 46 could be "snap fit" on to cartridge retainer assembly 10.
As shown in Fig. 1, body 12 of cartridge retainer assembly 10 includes a plurality 15 of inwardly projecting supports 65 separated from one another by notches 62, wherein supports 65 are used to hold insert tip 20 in distal end 16 of cartridge retainer assembly 10. Fig. 2 is a cross-sectional view of cartridge retainer assembly 10 that shows cartridge assembly 22 within a cartridge receiving chamber 68. Figs. 1 and 2 also show an array of threads 13 on proximal end 14 of body 12 used to engage threads 41 on distal end 42 of 20 dosing apparatus 38.
Needle mounting insert tip 20 of cartridge retainer assembly 10 includes opposedproximal and distal ends 72 and 74, respectively. As shown in Fig. 2, proxi,llal end 72 of needle mounting insert tip 20 includes a rim 76 extending thel~rlonl that is diametrically CA 0221419~ 1997-08-28 , dimensioned to closely engage metallic sleeve 34 crimped to cartridge assembly 22 for holding mbber septum 32 in place. Distal end 74 of needle mounting insert tip ~0 includes a generally annular end wall 84 having an aperture 86 extending therethrough for access by proximal point 50 of needle cannula 48. An array of outwardly disposed threads 88 is defined intermediate proximal and distal ends 72 and 74, respectively. Threads 88 are disposed and dimensioned for eng~ging threads on needle assembly 46.
Assembly of medication delivery pen 11 is performed by inserting cartridge assembly 22 into cartridge retainer assembly 10. More particularly, neck 30 and crimped 0 metallic sleeve 34 of cartridge assembly 22 are inserted in a proximal to distal direction into open proximal end 14 of body 12 of cartridge retainer assembly 10. Crimped metallic sleeve 34 eventually will pass entirely through body 12, and further advancement of cartridge assembly 22 into cartridge retainer assembly 10 will require entry of crimped metallic sleeve 34 into rim 76 extending from proximal end 72 of needle mounting insert tip 20. Considerable dimensional variation and eccentricities between the neck and body of prior art cartridges are ~nown to exist. If such eccentricities do exist, crimped metallic sleeve 34 will rest on rim 76 of insert tip 20 to center sleeve 34 relative to body 12 into a position that conforms with any dimensional incon.~i~t~ncies or eccentricities in cartridge assembly 22.
Further distally directed movement of cartridge assembly 22 into cartridge retainer assembly 10 will cause shoulder 28 of cartridge assembly 22 to seat against rim 76 of insert tip 20. ~im 76 therefore defines the fully seated position of cartridge assembly 22 in cartridge retainer assembly 10 and functions to securely engage cartridge assembly 22. In 2 5 this fully seated position, as shown most clearly in Fig. 2, septum 32 of cartridge assembly CA 0221419~ 1997-08-28 22 is spaced proximally from distal wall 84 of needle mounting insert tip 20. Dosin~
apparatus 38 is then assembled to proximal end 14 of the body of cartridge retainer assembly 10 such that plunger rod 44 of dosing apparatus 38 engages stopper 26 of cartridge assembly 22.
Medication delivery pen 11 is used by mounting needle assembly 46 to needle mounting insert tip 20 of cartridge retainer assembly 10. This mounting is achieved by moving needle assembly 46 in a proximal direction over needle mounting insert tip 20 until the threads (not shown) of cap 56 engage external threads 88 on needle mounting insert lo tip 20. Threads 88 of needle mounting insert tip 20 are spaced from the extreme distal end of needle mounting insert tip 20, therefore, the initial axial advancement of cap 56 over needle mounting insert tip 20 will cause proximal point 50 of needle cannula 48 to pierce rubber septum 32 of cartridge assembly 22 prior to rotational threaded engagement of needle assembly 46 with needle mounting insert tip 20. Thus, the bevel which defines 5 proximal point 50 will advance axially through septum 32 without a rotation that could tear rubber septum 32.
After threads of cap 56 engage threads 88 of needle mounting insert tip 20, further advancement of needle assembly 46 requires relative rotation between cap 56 and needle 20 mounting insert tip 20. It will be appreciated that needle mounting insert tip 20 is too small to be readily griped by the user of medication delivery pen 11, and is partly covered by cap 56. However, the relative rotation can be achieved by rotating body 12 ofcartridge retainer assembly 10. Since needle mounting insert tip 20 is locked to distal end 16 on body 12 of cartridge retainer assembly 10, rotation of body 12 is transmitted to 25 needle mounting insert tip 20 and enables complete rotational engagement of needle CA 0221419~ 1997-08-28 assembly 46.
Use of medication delivery pen l l proceeds in a conventional manner with dosingapparatus 38. Actuation of dosing apparatus 38 causes liquid medication in cartridge assembly 22 to be urged in a distal direction through lumen 51 of needle cannula 48. This distally directed liquid pressure also will cause septum 32 to distend in a distal direction.
However, as noted above and as shown in Fig. 2, septum 32 is spaced proximally from cork ~4 of needle assembly 46, and will not be urged into contact with cork 54. Thus, drooling or weeping of liquid medication can be substantially prevented. This is enabled 0 because cartridge assembly 22 is supported and accurately positioned by engagement of cartridge shoulder 28 with rim 76 on insert tip 20. Hence neck 30 and crimped metallic sleeve 34 need not be closely engaged by needle mounting insert tip 20. After medication delivery pen l 1 has been used, needle assembly 46 is separated from needle mounting insert tip 20 and discarded.
In the foregoing discussion, it is to be understood that the above-described embodiments of the present invention are simply illustrative of various features of a cartridge retainer assembly for a medication delivery pen. Other suitable variations, ~ modifications and combinations of these features could be made to or used in these 2 0 embodiments and still remain within the scope of the present invention.
Medication delivery pens are hypodermic syringes used for self-injection of precisely measured doses of medication. Pens are widely used, for example, by diabetics to dispense insulin.
.
A typical prior art medication delivery pen includes a cartridge which contains a volume of liquid medication sufficient for several doses. The cartridge ;n~ ld~s an elongated generally tubular glass cartridge having a pierceable rubber septum which extends across the open distal end of the car~lidge and ~ securely heId in position by a .. . ..
.
.
metallic sleeve that is crimped to the distal end of the cartridge. The cartridge also includes a rubber stopper in sliding fluid-tight engagement with interior walls of the cartridge.
Such a medication delivery pen also includes a unitarily molded cartridge retainer having a small diameter tubular neck dimensioned for tightly çn~ging the neck of the cartridge and the metallic sleeve crimped thereon so as to support and position the entire ~ cartridge. Exterior regions at the extreme distal end of the tubular neck are formed with an array of threads for threadedly receiving the mounting cap of a needle assembly. The medication delivery pen further includes a dosing al~pal~Lus that is engaged with the proximal end of the cartridge retainer having a plunger for ~ng~ging the rubber stopper of the cartridge. The dosing apparatus includes a dose setting structure used to select the longitudinal distance through which the plunger will move, and dispensing means for driving the plunger the selected distance.
The needle assembly for the medication delivery pen includes an elongate needle c~nn~ having opposed prox~,llal and distal points and a lumen e~t~nding therethrough.
A plastic cork is adhered to an intermediate position along the needle cannula and in turn is rigidly connected to an end wall of a cylindrical cap. The cylindrical wall of the cap surrounds the proximal point on the needle cannula and inc,l~ldes an array of internal threads for ~n~,~ing the external threads on the neck of the cartridge retainer.
The medication delivery pen may be used by urging the cap of the needle assemblyover the neck of the cartridge retainer sufficiently for the proximal point of the needle ~ nmll~ to pierce the rubber septum ofthe cartridge. The cap is then rotated to threadedly CA 0221419~ 1997-08-28 engage the neck of the cartridge retainer. The user then manipulates the dosing apparatus to select an appropriate dose. A protective shield over the distal end of the needle cannula is then removed, and the distal point of the needle cannula is injected. The user then actuates the dispensing means of the prior art dosing apparatus to urge the stopper of the 5 cartridge distally and to deliver medication through the lumen of the needle cannula. The needle is then withdrawn, and the needle assembly is separated from the cartridge retainer and safely discarded. The rubber septum of the cartridge reseals itself, and may be pierced ~ again for a subsequent ~(lmini~tration of medication. This process may be carried out repeatedly until all of the medication in the cartridge has been used.
A problem with currently available needle assemblies for use on medication delivery pens is the size of the c~nn~ Prior to the present invention, 27, 28, 29 and 30 gauge needle c~nn~ have been commonly used on medication delivery pens, with 30 gauge being the smallest diameter possible. Even though smaller gauges, i.e., 29 and 30 5 gauge, have helped to reduce pain to patients during injection, there is still a need to provide needle assemblies for medication delivery pens with smaller c~nnlll~ diameters since small diameter needles are perceived by patients to cause less pain during the injection. However, no one skilled in the art has suggested and no one has provided patients with needle assemblies having a diameter less than 30 gauge.
SUMMA~Y OF T~ INVENTION
The present invention overcomes the 30 gauge limit that has existed for pen needle assemblies by providing a 3 l gauge needle assembly for use on medication delivery pens.
2 5 The 3 l gauge needle provides a patient with a needle assembly having a smaller cannula , size without loss in per~ormance or structural integrity. The 3 l gauge needle assembly mounts on a needle mounting tip of a cartridge retainer assembly on a medication delivery pen and is used like prior art needle assemblies to pierce a patient's arm during an injection process.
However, since the 31 gauge needle cannula is smaller than prior art needle cannulas the penetration force is decreased which reduces the pain caused during an injection procedure. In addition, the smaller cannula size will be seen by the patient prior to the injection so that perceived pain or anticipated pain is also reduced. The reduction in 10 actual and perceived/anticipated pain provided by using the 3 l gauge needle on the medication delivery pen is a major benefit to patients that need numerous injections each day, i.e., diabetics requiring insulin injections.
These and other aspects, features and advantages of the present invention will 15 become apparent from the following detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRA~INGS
2 0 Fig. 1 is an exploded perspective view of a medication delively pen having a needle assembly in accordance with the subject invention; and Fig. 2 is a cross-sectional view of a cartridge retainer assembly of the medication delivery pen.
~ , , , DETAILl~P PESCRIPTIQN OF THE PREFERRED EM~C)l~)I~NT
A needle assembly for use on a medication delive~y pen 1 1, in accordance w~th the subject invention, is identified generally by the numeral 46 in Fig. l As shown in Fig. 1 5 medication delivery pen 11 includes a cartridge retainer assembly 10, a dosing apparatus 38 and a cartridge assembly 22. Needle assembly 46, as described in more detail below, is designed to be attached to a needle mounting insert tip 20 on cartridge retainer assembly Cartridge retainer assembly 10, as shown in Figs. 1 and 2, includes an elongate generally tubular body 12 with opposed proximal and distal ends 14 and 16, respectively.
A generally tubular needle mounting insert tip 20 is snap-fit mounted in distal end 16 of body 12 and cartridge retainer assembly 10 is dimensioned and configured to receive a cartridge assembly 22 therein.
Cartridge assembly 22 includes an open proximal end 26 and a distal end 25 defined by an inwardly converging shoulder 28. A small diameter neck 30 projects distally from shoulder 28 on cartridge assembly 22, and is provided with a large ~ met~r annular bead 24 e~n~ling circu,l~,e"Lially thereabout at the extreme distal end of neck 30. A
2 o pierceable and resealable rubber septum 32 extends completely across the open distal end defined by neck 30. Rubber septum 32 is held in place by a metallic sleeve 34 which is crimped around bead 24 at the distal end of neck 30. Medication such as insulin or heparin is pre-filled into cartridge assembly 22 and is retained therein by a rubber stopper 36. Stopper 36 is in sliding fluid-tight engagement with the tubular wall of cartridge assembly 22. Distally directed forces on stopper 36 urge the medication from pen 11 as explained further below.
Dosing ~Ippdlal~lS 38 in medication delivery pen 11 is generally cylindrical andincludes opposed proximal and distal ends 40 and 42, respectively. Threads 41 are S disposed at distal end 42 of dosing apparatus 38 for releasable threaded engagement with proximal end 14 of body 12 of cartridge retainer assembly 10. A plunger rod 44 projects distally from dosing apparatus 38 and is dimensioned to engage stopper 36 of cartridge assembly 22. Dosing apparatus 38 also includes known mech~ni.cm~ for setting a selected dose of medication to be delivered by pen 11. A dispensing mech~ni~m (not shown) is 10 operative to drive plunger rod 44 a selected distance in a distal direction for moving stopper 36 a distance that will inject the selected dose of medication from cartridge assembly 22. Although a particular prior art dosing apparatus 38 is depicted in Fig. 1, it is to be understood that other dosing apparatus can be used with the needle assembly of the subject invention.
Needle assembly 46, according to the present invention, includes a 31 gauge needle c~nnl71~ 48 with opposed ~ imal and distal tips 50 and 52, respectively, and a lumen 51 ~.~çn~lin~ entirely therethrough. The dimensions of 31 gauge needle cannula 48 are set forth below:
Parameter Value Outer Diameter 0.010"-0.0105"
Inner Diameter 0.0045"-0.006"
Wall Thickness0.00225"-0.00275"
Usablelength 0.315" (8mm) CA 0221419~ 1997-08-28 Cannula ~laterial Stainless Steel Of course, 31 gauge needle cannulas of other lengths can also be used, i.e., 0.236" (6mm) or 0.394" (I Omm), and still remain within the scope of the present invention. A cork 54 is securely affixed at an intermediate position along needle cannula 48, and a cap 56 is securely affixed to cork 54. Cap 56 of needle assembly 46 includes an array of internal threads (not shown) for removable mounting needle assembly 46 to needle mounting inse~t tip 20 on cartridge retainer assembly 10. It is to be understood, however, that other releasable engagement means between needle assembly 46 and cartridge retainer assembly 10 can be provided. For example, external threads can be formed on needle assembly 46 lo and corresponding internal threads can be defined on cartridge retainer assembly 10 or a bayonet style mounting using lugs and slots can be used. In addition, needle assembly 46 could be "snap fit" on to cartridge retainer assembly 10.
As shown in Fig. 1, body 12 of cartridge retainer assembly 10 includes a plurality 15 of inwardly projecting supports 65 separated from one another by notches 62, wherein supports 65 are used to hold insert tip 20 in distal end 16 of cartridge retainer assembly 10. Fig. 2 is a cross-sectional view of cartridge retainer assembly 10 that shows cartridge assembly 22 within a cartridge receiving chamber 68. Figs. 1 and 2 also show an array of threads 13 on proximal end 14 of body 12 used to engage threads 41 on distal end 42 of 20 dosing apparatus 38.
Needle mounting insert tip 20 of cartridge retainer assembly 10 includes opposedproximal and distal ends 72 and 74, respectively. As shown in Fig. 2, proxi,llal end 72 of needle mounting insert tip 20 includes a rim 76 extending thel~rlonl that is diametrically CA 0221419~ 1997-08-28 , dimensioned to closely engage metallic sleeve 34 crimped to cartridge assembly 22 for holding mbber septum 32 in place. Distal end 74 of needle mounting insert tip ~0 includes a generally annular end wall 84 having an aperture 86 extending therethrough for access by proximal point 50 of needle cannula 48. An array of outwardly disposed threads 88 is defined intermediate proximal and distal ends 72 and 74, respectively. Threads 88 are disposed and dimensioned for eng~ging threads on needle assembly 46.
Assembly of medication delivery pen 11 is performed by inserting cartridge assembly 22 into cartridge retainer assembly 10. More particularly, neck 30 and crimped 0 metallic sleeve 34 of cartridge assembly 22 are inserted in a proximal to distal direction into open proximal end 14 of body 12 of cartridge retainer assembly 10. Crimped metallic sleeve 34 eventually will pass entirely through body 12, and further advancement of cartridge assembly 22 into cartridge retainer assembly 10 will require entry of crimped metallic sleeve 34 into rim 76 extending from proximal end 72 of needle mounting insert tip 20. Considerable dimensional variation and eccentricities between the neck and body of prior art cartridges are ~nown to exist. If such eccentricities do exist, crimped metallic sleeve 34 will rest on rim 76 of insert tip 20 to center sleeve 34 relative to body 12 into a position that conforms with any dimensional incon.~i~t~ncies or eccentricities in cartridge assembly 22.
Further distally directed movement of cartridge assembly 22 into cartridge retainer assembly 10 will cause shoulder 28 of cartridge assembly 22 to seat against rim 76 of insert tip 20. ~im 76 therefore defines the fully seated position of cartridge assembly 22 in cartridge retainer assembly 10 and functions to securely engage cartridge assembly 22. In 2 5 this fully seated position, as shown most clearly in Fig. 2, septum 32 of cartridge assembly CA 0221419~ 1997-08-28 22 is spaced proximally from distal wall 84 of needle mounting insert tip 20. Dosin~
apparatus 38 is then assembled to proximal end 14 of the body of cartridge retainer assembly 10 such that plunger rod 44 of dosing apparatus 38 engages stopper 26 of cartridge assembly 22.
Medication delivery pen 11 is used by mounting needle assembly 46 to needle mounting insert tip 20 of cartridge retainer assembly 10. This mounting is achieved by moving needle assembly 46 in a proximal direction over needle mounting insert tip 20 until the threads (not shown) of cap 56 engage external threads 88 on needle mounting insert lo tip 20. Threads 88 of needle mounting insert tip 20 are spaced from the extreme distal end of needle mounting insert tip 20, therefore, the initial axial advancement of cap 56 over needle mounting insert tip 20 will cause proximal point 50 of needle cannula 48 to pierce rubber septum 32 of cartridge assembly 22 prior to rotational threaded engagement of needle assembly 46 with needle mounting insert tip 20. Thus, the bevel which defines 5 proximal point 50 will advance axially through septum 32 without a rotation that could tear rubber septum 32.
After threads of cap 56 engage threads 88 of needle mounting insert tip 20, further advancement of needle assembly 46 requires relative rotation between cap 56 and needle 20 mounting insert tip 20. It will be appreciated that needle mounting insert tip 20 is too small to be readily griped by the user of medication delivery pen 11, and is partly covered by cap 56. However, the relative rotation can be achieved by rotating body 12 ofcartridge retainer assembly 10. Since needle mounting insert tip 20 is locked to distal end 16 on body 12 of cartridge retainer assembly 10, rotation of body 12 is transmitted to 25 needle mounting insert tip 20 and enables complete rotational engagement of needle CA 0221419~ 1997-08-28 assembly 46.
Use of medication delivery pen l l proceeds in a conventional manner with dosingapparatus 38. Actuation of dosing apparatus 38 causes liquid medication in cartridge assembly 22 to be urged in a distal direction through lumen 51 of needle cannula 48. This distally directed liquid pressure also will cause septum 32 to distend in a distal direction.
However, as noted above and as shown in Fig. 2, septum 32 is spaced proximally from cork ~4 of needle assembly 46, and will not be urged into contact with cork 54. Thus, drooling or weeping of liquid medication can be substantially prevented. This is enabled 0 because cartridge assembly 22 is supported and accurately positioned by engagement of cartridge shoulder 28 with rim 76 on insert tip 20. Hence neck 30 and crimped metallic sleeve 34 need not be closely engaged by needle mounting insert tip 20. After medication delivery pen l 1 has been used, needle assembly 46 is separated from needle mounting insert tip 20 and discarded.
In the foregoing discussion, it is to be understood that the above-described embodiments of the present invention are simply illustrative of various features of a cartridge retainer assembly for a medication delivery pen. Other suitable variations, ~ modifications and combinations of these features could be made to or used in these 2 0 embodiments and still remain within the scope of the present invention.
Claims (9)
1. A medication delivery pen for delivering medication to a patient during an injection procedure comprising:
a needle assembly having a 31 gauge needle cannula;
a cartridge assembly containing medication having a proximal and distal end, said proximal end including an array of threads and a stopper and said distal end including means for attaching said needle assembly so that medication can flow through said 31 gauge needle cannula during an injection procedure; and a dosing apparatus having opposed proximal and distal ends with an array of threads at said distal end for threaded engagement with said threads at said proximal end of said cartridge assembly, said dosing apparatus further comprising a plunger rod projecting beyond said distal end of said dosing apparatus for selective engagement with said stopper in said cartridge assembly, and means for moving said plunger rod distally in said dosing apparatus selected amounts, whereby said plunger rod moves said stopper in said cartridge assembly to dispense medication from said cartridge assembly through said 31 gauge needle cannula.
a needle assembly having a 31 gauge needle cannula;
a cartridge assembly containing medication having a proximal and distal end, said proximal end including an array of threads and a stopper and said distal end including means for attaching said needle assembly so that medication can flow through said 31 gauge needle cannula during an injection procedure; and a dosing apparatus having opposed proximal and distal ends with an array of threads at said distal end for threaded engagement with said threads at said proximal end of said cartridge assembly, said dosing apparatus further comprising a plunger rod projecting beyond said distal end of said dosing apparatus for selective engagement with said stopper in said cartridge assembly, and means for moving said plunger rod distally in said dosing apparatus selected amounts, whereby said plunger rod moves said stopper in said cartridge assembly to dispense medication from said cartridge assembly through said 31 gauge needle cannula.
2. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has an outer diameter less than 0.0105 inches.
3. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has an outer diameter no smaller than 0.010 inches and no larger than 0.0105 inches.
4. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has an inner diameter no smaller than 0.0045 inches and no larger than 0.006 inches.
5. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula is made of stainless steel.
6. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has a usable length of approximately 0.315 inches.
7. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has a usable length of approximately 0.236 inches.
8. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has a usable length of approximately 0.394 inches.
9. A medication delivery pen according to claim 1, wherein said 31 gauge needle cannula has a wall thickness no smaller than 0.00225 inches and no larger than 0.00275 inches.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/721,368 | 1996-09-26 | ||
US08/721,368 US6146361A (en) | 1996-09-26 | 1996-09-26 | Medication delivery pen having a 31 gauge needle |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2214195A1 true CA2214195A1 (en) | 1998-03-26 |
Family
ID=24897700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002214195A Abandoned CA2214195A1 (en) | 1996-09-26 | 1997-08-28 | Medication delivery pen having a 31 gauge needle |
Country Status (4)
Country | Link |
---|---|
US (2) | US6146361A (en) |
EP (1) | EP0832661A3 (en) |
JP (2) | JPH10113390A (en) |
CA (1) | CA2214195A1 (en) |
Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7235056B2 (en) | 1996-05-17 | 2007-06-26 | Amira Medical | Body fluid sampling device and methods of use |
US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
HU222513B1 (en) | 1998-01-30 | 2003-08-28 | Novo Nordisk A/S | An injection syringe |
PL345336A1 (en) * | 1998-07-08 | 2001-12-17 | Novo Nordisk As | A medical delivery device and a cartridge assembly for use in the same |
JP2003517345A (en) * | 1999-05-28 | 2003-05-27 | ノヴォ ノルディスク アクティーゼルスカブ | Manufacturing method and system for plastic needle |
TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
US6494865B1 (en) * | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
JP2003531646A (en) * | 2000-01-18 | 2003-10-28 | スターリング メディヴェイションズ インコーポレイテッド | Pen needle assembly and adapter |
USD461555S1 (en) | 2000-05-25 | 2002-08-13 | Jean Marc Binet | Safety syringe |
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
US6540675B2 (en) * | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
JP4187922B2 (en) * | 2000-09-14 | 2008-11-26 | テルモ株式会社 | Liquid injection needle and liquid injection device |
JP2007283132A (en) * | 2000-09-14 | 2007-11-01 | Terumo Corp | Liquid injection needle and liquid injector |
KR20030079958A (en) | 2001-01-22 | 2003-10-10 | 에프. 호프만-라 로슈 아게 | Lancet device having capillary action |
US6595960B2 (en) * | 2001-04-12 | 2003-07-22 | Becton, Dickinson And Company | Flexible needle assembly |
DK1409044T3 (en) * | 2001-07-16 | 2008-01-02 | Lilly Co Eli | Injection apparatus without cartridge for multiple doses |
DE10163327A1 (en) * | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Reservoir module with piston rod |
DE10163328B4 (en) * | 2001-07-30 | 2005-08-11 | Tecpharma Licensing Ag | Administration device with anti-rotation device |
DE10163325B4 (en) * | 2001-07-30 | 2005-07-28 | Tecpharma Licensing Ag | Locking lock for connection of housing sections of an administering device |
DE10163326A1 (en) * | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Administration device with dosing device |
DE20112501U1 (en) * | 2001-07-30 | 2002-12-19 | Disetronic Licensing Ag | Locking lock for connecting housing parts of an injection or infusion device |
US20030100883A1 (en) * | 2001-08-31 | 2003-05-29 | Kristensen Lars Thougaard | Cartridge for liquid insulin |
KR20040029015A (en) * | 2001-08-31 | 2004-04-03 | 노보 노르디스크 에이/에스 | A cartridge for liquid insulin |
WO2003039369A1 (en) | 2001-09-26 | 2003-05-15 | Roche Diagnostics Gmbh | Method and apparatus for sampling bodily fluid |
JP3999489B2 (en) * | 2001-10-19 | 2007-10-31 | 住友ゴム工業株式会社 | Syringe |
DE20209051U1 (en) * | 2001-12-21 | 2003-04-24 | Disetronic Licensing Ag | Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop |
JP2003199827A (en) * | 2001-12-28 | 2003-07-15 | Terumo Corp | Syringe |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
FR2837735B1 (en) * | 2002-04-02 | 2004-07-23 | Prodonta | TOOL HOLDER FOR BENDING DEFORMABLE TOOL |
EP3375463A1 (en) | 2002-05-06 | 2018-09-19 | Becton, Dickinson and Company | Method and device for controlling drug pharmacokinetics |
US7654986B2 (en) * | 2002-07-03 | 2010-02-02 | Novo Nordisk A/S | Needle mounting system and a method for mounting a needle assembly |
DE10232411A1 (en) * | 2002-07-17 | 2004-02-05 | Disetronic Licensing Ag | Administration device with adjustable dosing stop |
US7021463B2 (en) | 2002-09-06 | 2006-04-04 | Becton, Dickinson And Company | Pen needle sharps port |
CN1723053A (en) | 2002-09-12 | 2006-01-18 | 儿童医院医疗中心 | Method and device for painless injection of medication |
WO2004060160A1 (en) * | 2002-12-24 | 2004-07-22 | Roche Diagnostics Gmbh | A sampling device utilizing biased capillary action |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US9205197B2 (en) | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
GB0308267D0 (en) | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
JP2004343275A (en) * | 2003-05-14 | 2004-12-02 | Murata Mach Ltd | Image processing system and scanner |
US20050027255A1 (en) * | 2003-07-31 | 2005-02-03 | Sid Technologies, Llc | Automatic injector |
WO2005025641A2 (en) | 2003-08-28 | 2005-03-24 | Becton, Dickinson And Company | Intradermal injection device |
US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
CA2584760C (en) | 2004-10-21 | 2013-12-24 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
WO2006114396A1 (en) | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | Injection device |
US20060281187A1 (en) * | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
US8801631B2 (en) * | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
WO2007041244A2 (en) | 2005-09-30 | 2007-04-12 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
US8133202B2 (en) * | 2005-10-13 | 2012-03-13 | Becton, Dickinson And Company | Disposable needle and hub assembly |
HUE029798T2 (en) * | 2005-11-04 | 2017-03-28 | Glaxosmithkline Llc | Methods for administering hypoglycemic agents |
US7842008B2 (en) | 2005-11-21 | 2010-11-30 | Becton, Dickinson And Company | Intradermal delivery device |
WO2007083518A1 (en) * | 2006-01-23 | 2007-07-26 | Yoshio Oyama | An ampoule usable as a syringe and a syringe unit comprising the ampoule |
GB0603926D0 (en) * | 2006-02-28 | 2006-04-05 | Owen Mumford Ltd | Syringes |
CN101400394B (en) | 2006-03-10 | 2012-07-04 | 诺沃-诺迪斯克有限公司 | An injection device having a gearing arrangement |
US8298194B2 (en) | 2006-03-10 | 2012-10-30 | Novo Nordisk A/S | Injection device and a method of changing a cartridge in the device |
EP2019701B1 (en) | 2006-05-16 | 2010-02-24 | Novo Nordisk A/S | A gearing mechanism for an injection device |
ES2389866T3 (en) | 2006-05-18 | 2012-11-02 | Novo Nordisk A/S | Injection device with locking mode |
DE602007012354D1 (en) | 2006-07-15 | 2011-03-17 | Novo Nordisk As | MEDICAL DISCHARGE SYSTEM WITH ROTATABLE END CAP |
US8653066B2 (en) | 2006-10-09 | 2014-02-18 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US20090124996A1 (en) * | 2006-11-03 | 2009-05-14 | Scott Heneveld | Apparatus and methods for injecting high viscosity dermal fillers |
CN101541364B (en) | 2006-11-21 | 2012-07-18 | 诺沃-诺迪斯克有限公司 | Medical delivery system comprising locking ring with l-shaped grooves |
AU2008213084B2 (en) | 2007-02-05 | 2013-03-28 | Novo Nordisk A/S | Injection button |
US8353878B2 (en) | 2007-03-23 | 2013-01-15 | Novo Nordisk A/S | Injection device comprising a locking nut |
USD675316S1 (en) | 2007-08-22 | 2013-01-29 | Novo Nordisk A/S | Needle hub |
US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
WO2009044401A2 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
WO2009086250A1 (en) | 2007-12-21 | 2009-07-09 | Aesthetic Sciences Corporation | Self-contained pressurized injection device |
EP2240022B1 (en) | 2008-01-09 | 2016-12-28 | Charleston Laboratories, Inc. | Bilayered tablets comprising oxycodone and promethazine |
EP2240225B1 (en) * | 2008-01-15 | 2016-12-07 | Becton, Dickinson and Company | Medical injector with pen needle assembly |
FR2926997B1 (en) * | 2008-02-04 | 2012-06-29 | Bernard Hertzog | SOFT FLEXIBLE NEEDLES FOR SKIN INJECTION WITHOUT PAIN |
JP5313236B2 (en) | 2008-04-10 | 2013-10-09 | パナソニック株式会社 | Drug administration device |
JP5816080B2 (en) | 2008-05-30 | 2015-11-17 | インテュイティ メディカル インコーポレイテッド | Body fluid collection device and collection site interface |
CA2726067C (en) | 2008-06-06 | 2020-10-20 | Intuity Medical, Inc. | Detection meter and mode of operation |
JP2011522594A (en) | 2008-06-06 | 2011-08-04 | インテュイティ メディカル インコーポレイテッド | Medical diagnostic apparatus and method |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
US8617126B2 (en) * | 2008-09-15 | 2013-12-31 | Medimop Medical Projects Ltd. | Painless injector |
US9427529B2 (en) | 2008-09-15 | 2016-08-30 | Medimop Medical Projects Ltd. | Safeguard mechanism for autoinjector needle |
US20100145305A1 (en) * | 2008-11-10 | 2010-06-10 | Ruth Alon | Low volume accurate injector |
US8152779B2 (en) * | 2008-12-30 | 2012-04-10 | Medimop Medical Projects Ltd. | Needle assembly for drug pump |
US8573027B2 (en) | 2009-02-27 | 2013-11-05 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
US9250106B2 (en) | 2009-02-27 | 2016-02-02 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
KR101162529B1 (en) * | 2009-04-24 | 2012-07-03 | 이희영 | Injector for injecting medical yarn |
WO2011006012A1 (en) | 2009-07-08 | 2011-01-13 | Charleston Laboratories Inc. | Pharmaceutical compositions |
CA2921304C (en) | 2009-07-30 | 2018-06-05 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US10071196B2 (en) | 2012-05-15 | 2018-09-11 | West Pharma. Services IL, Ltd. | Method for selectively powering a battery-operated drug-delivery device and device therefor |
US8157769B2 (en) * | 2009-09-15 | 2012-04-17 | Medimop Medical Projects Ltd. | Cartridge insertion assembly for drug delivery system |
US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
US8919605B2 (en) | 2009-11-30 | 2014-12-30 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
CN102762245A (en) * | 2009-12-28 | 2012-10-31 | 斯坦利·金 | Pain free hypodermic needle |
US8348898B2 (en) | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
PL2563813T3 (en) | 2010-04-30 | 2016-01-29 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
US9022988B1 (en) | 2010-05-07 | 2015-05-05 | Kavan J. Shaban | System and method for controlling a self-injector device |
US9452261B2 (en) | 2010-05-10 | 2016-09-27 | Medimop Medical Projects Ltd. | Low volume accurate injector |
MX2012014975A (en) | 2010-06-22 | 2013-03-12 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3. |
EP2584964B1 (en) | 2010-06-25 | 2021-08-04 | Intuity Medical, Inc. | Analyte monitoring devices |
CN106880493B (en) * | 2011-01-17 | 2021-03-12 | 阿克蒂夫帕克股份有限公司 | Aseptic cartridge and dispenser device |
WO2012106634A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
USD702834S1 (en) | 2011-03-22 | 2014-04-15 | Medimop Medical Projects Ltd. | Cartridge for use in injection device |
US20130085349A1 (en) | 2011-06-21 | 2013-04-04 | Yofimeter, Llc | Analyte testing devices |
US8672883B2 (en) | 2011-07-11 | 2014-03-18 | C. Garyen Denning | Fluid delivery device and methods |
WO2013020103A1 (en) | 2011-08-03 | 2013-02-07 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
CN102327656B (en) * | 2011-10-18 | 2013-05-08 | 清华大学 | Disposable array miniature injection needle head |
AU2012326097B2 (en) | 2011-10-20 | 2015-08-13 | Becton, Dickinson And Company | Mixing element for container assemblies |
US9533106B2 (en) | 2011-12-29 | 2017-01-03 | Novo Nordisk A/S | Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism |
US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9421323B2 (en) | 2013-01-03 | 2016-08-23 | Medimop Medical Projects Ltd. | Door and doorstop for portable one use drug delivery apparatus |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
CA2897334A1 (en) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
US9011164B2 (en) | 2013-04-30 | 2015-04-21 | Medimop Medical Projects Ltd. | Clip contact for easy installation of printed circuit board PCB |
CA2912283A1 (en) | 2013-06-21 | 2014-12-21 | Intuity Medical, Inc. | Analyte monitoring system with audible feedback |
EP3033087A4 (en) | 2013-08-16 | 2017-03-15 | The J. David Gladstone Institutes | Compositions and methods for identifying latently infected cells |
NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
EP3206751A4 (en) | 2014-10-14 | 2018-06-13 | The J. David Gladstone Institutes | Compositions and methods for reactivating latent immunodeficiency virus |
US11400218B2 (en) * | 2015-03-23 | 2022-08-02 | Sanofi-Aventis Deutschland Gmbh | Housing for an injection device and interconnection of housing components |
US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
US10149943B2 (en) | 2015-05-29 | 2018-12-11 | West Pharma. Services IL, Ltd. | Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly |
US11207465B2 (en) | 2015-06-04 | 2021-12-28 | West Pharma. Services Il. Ltd. | Cartridge insertion for drug delivery device |
US9987432B2 (en) | 2015-09-22 | 2018-06-05 | West Pharma. Services IL, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
US10086145B2 (en) | 2015-09-22 | 2018-10-02 | West Pharma Services Il, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
JP7017512B2 (en) | 2015-10-09 | 2022-02-08 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Bending fluid path type accessories for filled fluid containers |
EP4310503A3 (en) | 2015-12-30 | 2024-03-20 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
CN113041432B (en) | 2016-01-21 | 2023-04-07 | 西医药服务以色列有限公司 | Medicament delivery device comprising a visual indicator |
JP6542481B2 (en) | 2016-01-21 | 2019-07-10 | ウェスト ファーマ サービシーズ イスラエル リミテッド | system |
EP3711793B1 (en) | 2016-01-21 | 2021-12-01 | West Pharma Services IL, Ltd. | A method of connecting a cartridge to an automatic injector |
CA3055170A1 (en) | 2016-03-04 | 2017-09-08 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
US10376647B2 (en) | 2016-03-18 | 2019-08-13 | West Pharma. Services IL, Ltd. | Anti-rotation mechanism for telescopic screw assembly |
WO2017187262A1 (en) | 2016-04-25 | 2017-11-02 | Marc Andrew Koska | Medical delivery system |
EP3463526A1 (en) | 2016-06-02 | 2019-04-10 | West Pharma. Services Il, Ltd. | Three position needle retraction |
USD839422S1 (en) * | 2016-07-08 | 2019-01-29 | Gerresheimer Regensburg Gmbh | Needle protection for a syringe device |
JP7059251B2 (en) | 2016-08-01 | 2022-04-25 | ウェスト ファーマ サービシーズ イスラエル リミテッド | A spring that prevents the door from closing halfway |
JP6869327B2 (en) | 2016-08-01 | 2021-05-12 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Anti-rotation cartridge |
US10251964B2 (en) | 2016-08-23 | 2019-04-09 | Drma Group International Llc | Self-disinfecting needleless device |
US10195110B2 (en) | 2016-09-08 | 2019-02-05 | Drma Group International Llc | Capping device for disinfecting medical container |
US10391294B2 (en) | 2016-09-12 | 2019-08-27 | Drma Group International Llc | Disinfecting cap |
US10926025B2 (en) | 2016-09-15 | 2021-02-23 | Tandem Diabetes Care, Inc. | Vial supporter for medicament pump |
US10610676B2 (en) | 2016-09-26 | 2020-04-07 | Drma Group International Llc | Disinfecting luer connector |
US10182968B2 (en) | 2017-03-06 | 2019-01-22 | Drma Group International Llc | Disinfecting capping device for sharp medical objects |
CN110869072B (en) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | Modular drive mechanism for a wearable injector |
US11541219B2 (en) | 2017-07-10 | 2023-01-03 | Drma Group International Llc | Capping device for disinfecting medical injection membranes |
SI3658184T1 (en) | 2017-07-27 | 2024-01-31 | Alexion Pharmaceuticals, Inc., | High concentration anti-c5 antibody formulations |
EP4360651A2 (en) | 2017-08-24 | 2024-05-01 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
EP3710086A4 (en) | 2017-11-17 | 2021-11-17 | Koska Family Limited | Systems and methods for fluid delivery manifolds |
WO2019126133A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals, Inc. | Liquid formulations of anti-cd200 antibodies |
CN114470420A (en) | 2017-12-22 | 2022-05-13 | 西氏医药包装(以色列)有限公司 | Syringe adapted for cartridges of different sizes |
WO2020041333A1 (en) | 2018-08-22 | 2020-02-27 | The J. David Gladstone Institutes | Methods for treating cardiac valve disease |
US11154663B2 (en) * | 2018-10-25 | 2021-10-26 | Sharps Technology Inc. | Pre-filled safety needle and syringe system |
CA3177829A1 (en) | 2018-12-12 | 2020-06-18 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
US20220364119A1 (en) | 2019-06-14 | 2022-11-17 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J.David Gladst | Compositions and methods for treating an immunodeficiency virus infection with a therapeutic interfering particle |
EP4106724A1 (en) | 2020-02-18 | 2022-12-28 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
BR112022021450A2 (en) | 2020-04-24 | 2022-12-27 | Millennium Pharm Inc | CD19 OR LEADING FRAGMENT, METHOD OF TREATMENT OF A CANCER, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID, VECTOR AND, ISOLATED CELL |
WO2021226564A1 (en) * | 2020-05-08 | 2021-11-11 | Koska Family Limited | Systems and methods for pre-filled multi-liquid medical delivery devices |
WO2022036041A1 (en) | 2020-08-14 | 2022-02-17 | Kite Pharma, Inc | Improving immune cell function |
CN116615443A (en) | 2020-09-14 | 2023-08-18 | Vor生物制药股份有限公司 | Single domain antibodies to CD33 |
WO2022066834A1 (en) * | 2020-09-25 | 2022-03-31 | Becton, Dickinson And Company | Washer component for cartridges and medical injection device including the same |
US11052196B1 (en) | 2020-11-03 | 2021-07-06 | Sun Pharmaceutical Industries Limited | Method of injecting octreotide acetate into the body |
JP2024505790A (en) | 2020-12-18 | 2024-02-08 | モメンタ ファーマシューティカルズ インコーポレイテッド | Antibodies against integrin alpha 11 beta 1 |
WO2022192439A1 (en) | 2021-03-11 | 2022-09-15 | Kite Pharma, Inc. | Improving immune cell function |
CN117425673A (en) | 2021-04-09 | 2024-01-19 | 武田药品工业株式会社 | Antibodies targeting complement factor D and uses thereof |
CA3216770A1 (en) | 2021-04-26 | 2022-11-03 | Tomoki Yoshihara | Anti-clec12a antibodies and uses thereof |
CN117580860A (en) | 2021-04-26 | 2024-02-20 | 米伦纽姆医药公司 | anti-ADGRE 2 antibodies and uses thereof |
USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
WO2023068382A2 (en) | 2021-10-20 | 2023-04-27 | Takeda Pharmaceutical Company Limited | Compositions targeting bcma and methods of use thereof |
WO2023201238A1 (en) | 2022-04-11 | 2023-10-19 | Vor Biopharma Inc. | Binding agents and methods of use thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4313439A (en) * | 1980-03-24 | 1982-02-02 | Biotek, Inc. | Automated, spring-powered medicament infusion system |
US4552561A (en) * | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
US4692142A (en) * | 1986-02-24 | 1987-09-08 | Dignam Bernard J | Sutureless infusion cannula for ophthalmic surgery |
GB8704027D0 (en) * | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
US4944677A (en) * | 1987-06-29 | 1990-07-31 | Raymond Joseph Alexandre | Intraosseus dental anesthesia apparatus and method |
US4973318A (en) * | 1988-02-10 | 1990-11-27 | D.C.P. Af 1988 A/S | Disposable syringe |
US4917670A (en) * | 1988-03-22 | 1990-04-17 | Hurley Ronald J | Continuous spinal anesthesia administering apparatus and method |
US4894054A (en) * | 1988-06-20 | 1990-01-16 | Miskinyar Shir A | Preloaded automatic disposable syringe |
US4969884A (en) * | 1988-12-28 | 1990-11-13 | Alza Corporation | Osmotically driven syringe |
NL8803204A (en) * | 1988-12-29 | 1990-07-16 | Tno | MEDICINAL NEEDLE FOR SINGLE USE. |
US5374256A (en) * | 1989-06-16 | 1994-12-20 | Science Incorporated | Fluid container for use with a fluid delivery apparatus |
FR2651314A1 (en) * | 1989-08-25 | 1991-03-01 | Taddei Andre | PORTABLE DEVICE FOR PERFORMING MULTIPLE ASSAYS OF A LIQUID OR PASTY PRODUCT. |
JPH03275214A (en) * | 1990-03-26 | 1991-12-05 | Suzuka Fuji Xerox Kk | Multilayered metallic pipe, manufacture thereof and injecting needle |
US5226896A (en) * | 1990-04-04 | 1993-07-13 | Eli Lilly And Company | Dose indicating injection pen |
US5151093A (en) * | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
US5709668A (en) * | 1991-01-16 | 1998-01-20 | Senetek Plc | Automatic medicament injector employing non-coring needle |
AU654857B2 (en) * | 1991-03-29 | 1994-11-24 | Collagen Corporation | Device and method for treating facial lines |
DK134691D0 (en) * | 1991-07-12 | 1991-07-12 | Novo Nordisk As | APPARATUS |
DK175491D0 (en) * | 1991-10-18 | 1991-10-18 | Novo Nordisk As | APPARATUS |
CA2098399A1 (en) * | 1991-10-22 | 1993-04-23 | Eugene Roberts | Method for memory enhancement and quality of life improvement |
US5279586A (en) * | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
JPH0686745A (en) * | 1992-09-08 | 1994-03-29 | Tokyo Electric Co Ltd | Suction port body of vacuum cleaner |
US5472022A (en) * | 1993-11-02 | 1995-12-05 | Genentech, Inc. | Injection pen solution transfer apparatus and method |
US5540657A (en) * | 1994-07-15 | 1996-07-30 | Collagen Corporation | Delivery device for injectable materials |
US5540357A (en) * | 1994-08-10 | 1996-07-30 | Loctite Corporation | Microwaveable adhesive charge comprising shaped adhesive body |
US5582598A (en) * | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
ATE196096T1 (en) * | 1996-04-24 | 2000-09-15 | Novo Nordisk As | INJECTION NEEDLE |
-
1996
- 1996-09-26 US US08/721,368 patent/US6146361A/en not_active Expired - Lifetime
-
1997
- 1997-06-05 US US08/869,612 patent/US6200296B1/en not_active Expired - Lifetime
- 1997-08-28 CA CA002214195A patent/CA2214195A1/en not_active Abandoned
- 1997-09-15 EP EP97307156A patent/EP0832661A3/en not_active Withdrawn
- 1997-09-18 JP JP9253025A patent/JPH10113390A/en active Pending
-
2000
- 2000-06-01 JP JP2000003748U patent/JP3073754U/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6200296B1 (en) | 2001-03-13 |
JP3073754U (en) | 2000-12-08 |
JPH10113390A (en) | 1998-05-06 |
EP0832661A3 (en) | 1998-06-03 |
US6146361A (en) | 2000-11-14 |
EP0832661A2 (en) | 1998-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6146361A (en) | Medication delivery pen having a 31 gauge needle | |
US5549575A (en) | Cartridge retainer assembly for medication delivery pen | |
JP4892161B2 (en) | Flexible needle assembly | |
EP2324875B1 (en) | Hub assembly having a hidden needle for a drug delivery pen | |
US3895633A (en) | Large capacity syringe | |
US7566324B2 (en) | Injection device comprising a needle cover | |
JP3824649B2 (en) | Pen syringe with cartridge loading mechanism | |
US9078977B2 (en) | Dual shielded syringe | |
JP4554577B2 (en) | Alignment aid for attaching the needle to the injection device | |
EP2506897B1 (en) | Pen needle removal device for a drug delivery device | |
US20070293819A1 (en) | Pen needle and safety shield system | |
US20050277896A1 (en) | Device for securing injection needles | |
EP0325049B1 (en) | Single-use syringe | |
US20100256572A1 (en) | Pre-Filled Syringe Apparatus Having Internal Guard | |
JP2006501036A (en) | Drug administration pen | |
US20040193110A1 (en) | Pen needle and safety shield system | |
US2864366A (en) | Hypodermic syringe adapter | |
JP7090084B2 (en) | Cap for integrated filling and injection of safety needle device | |
EP0829268A2 (en) | Non-floatable insulin cartridge holder for medication delivery pen | |
CN110152126B (en) | Pen needle | |
US20060111676A1 (en) | Passively guarded, pre-filled injection syringe | |
US20210128817A1 (en) | Needle unit with biostatic chamber | |
JPH0336360Y2 (en) | ||
US20020128610A1 (en) | Pen syringe needle adapter | |
CN112770797B (en) | Improvements relating to substance delivery devices |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |