CA2218112A1 - Hierarchical biological modelling system and method - Google Patents

Hierarchical biological modelling system and method

Info

Publication number
CA2218112A1
CA2218112A1 CA002218112A CA2218112A CA2218112A1 CA 2218112 A1 CA2218112 A1 CA 2218112A1 CA 002218112 A CA002218112 A CA 002218112A CA 2218112 A CA2218112 A CA 2218112A CA 2218112 A1 CA2218112 A1 CA 2218112A1
Authority
CA
Canada
Prior art keywords
information
model
phenomena
balanced
multiple sources
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218112A
Other languages
French (fr)
Other versions
CA2218112C (en
Inventor
Pamela K. Fink
Kenneth S. Kornman
Samuel Holtzman
Thomas S. Paterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interleukin Genetics Inc
Entelos Holding Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08422175 external-priority patent/US5657255C1/en
Application filed by Individual filed Critical Individual
Publication of CA2218112A1 publication Critical patent/CA2218112A1/en
Application granted granted Critical
Publication of CA2218112C publication Critical patent/CA2218112C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/90—Programming languages; Computing architectures; Database systems; Data warehousing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Abstract

A hierarchical biological modelling system and method provides integrated levels of information synthesized from multiple sources (116, 118, 120, 121, 124, 126). An executable model (114) of a biological system is developed from information and structures based on the multiple sources. The model is balanced to ensure that it matches the information and structures. Once the model is created and balanced it can be used to provide insight into phenomena at the cellular, or subcellular level, as well as phenomena at the patient, organ and system levels. From this information, clinical trials can be emulated, biologic targets for drug development can identified and subcellular phenomena over time can be observed. The model provides an integrated view of a multi-variable biological system.
CA002218112A 1995-04-14 1996-04-12 Hierarchical biological modelling system and method Expired - Fee Related CA2218112C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08422175 US5657255C1 (en) 1995-04-14 1995-04-14 Hierarchic biological modelling system and method
US08/422175 1995-04-14
PCT/US1996/005155 WO1996032684A1 (en) 1995-04-14 1996-04-12 Hierarchical biological modelling system and method

Publications (2)

Publication Number Publication Date
CA2218112A1 true CA2218112A1 (en) 1996-10-17
CA2218112C CA2218112C (en) 2007-07-17

Family

ID=38288172

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218112A Expired - Fee Related CA2218112C (en) 1995-04-14 1996-04-12 Hierarchical biological modelling system and method

Country Status (1)

Country Link
CA (1) CA2218112C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7069534B2 (en) 2003-12-17 2006-06-27 Sahouria Emile Y Mask creation with hierarchy management using cover cells
US7844431B2 (en) 2004-02-20 2010-11-30 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8554486B2 (en) 2004-02-20 2013-10-08 The Mathworks, Inc. Method, computer program product, and apparatus for selective memory restoration of a simulation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7069534B2 (en) 2003-12-17 2006-06-27 Sahouria Emile Y Mask creation with hierarchy management using cover cells
US7844431B2 (en) 2004-02-20 2010-11-30 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8234098B2 (en) 2004-02-20 2012-07-31 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8554486B2 (en) 2004-02-20 2013-10-08 The Mathworks, Inc. Method, computer program product, and apparatus for selective memory restoration of a simulation

Also Published As

Publication number Publication date
CA2218112C (en) 2007-07-17

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Effective date: 20160412