CA2218555A1 - Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs - Google Patents
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugsInfo
- Publication number
- CA2218555A1 CA2218555A1 CA002218555A CA2218555A CA2218555A1 CA 2218555 A1 CA2218555 A1 CA 2218555A1 CA 002218555 A CA002218555 A CA 002218555A CA 2218555 A CA2218555 A CA 2218555A CA 2218555 A1 CA2218555 A1 CA 2218555A1
- Authority
- CA
- Canada
- Prior art keywords
- compositions
- nonsteroidal antiinflammatory
- methods
- antiinflammatory drugs
- toxicity induced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising: (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed.
The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/425,090 | 1995-04-19 | ||
US08/425,090 US6051588A (en) | 1995-04-19 | 1995-04-19 | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US08/543,208 US5703073A (en) | 1995-04-19 | 1995-10-13 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US08/543,208 | 1995-10-13 | ||
PCT/US1996/004931 WO1996032946A1 (en) | 1995-04-19 | 1996-04-11 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2218555A1 true CA2218555A1 (en) | 1996-10-24 |
CA2218555C CA2218555C (en) | 2003-09-23 |
Family
ID=27026571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002218555A Expired - Fee Related CA2218555C (en) | 1995-04-19 | 1996-04-11 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
Country Status (6)
Country | Link |
---|---|
US (11) | US5703073A (en) |
EP (1) | EP0821589B1 (en) |
JP (2) | JPH11509519A (en) |
AU (1) | AU710951B2 (en) |
CA (1) | CA2218555C (en) |
WO (1) | WO1996032946A1 (en) |
Families Citing this family (119)
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-
1995
- 1995-10-13 US US08/543,208 patent/US5703073A/en not_active Expired - Lifetime
-
1996
- 1996-04-11 WO PCT/US1996/004931 patent/WO1996032946A1/en active Application Filing
- 1996-04-11 EP EP96911685A patent/EP0821589B1/en not_active Expired - Lifetime
- 1996-04-11 CA CA002218555A patent/CA2218555C/en not_active Expired - Fee Related
- 1996-04-11 JP JP8531797A patent/JPH11509519A/en active Pending
- 1996-04-11 AU AU54493/96A patent/AU710951B2/en not_active Ceased
-
1997
- 1997-09-16 US US08/931,564 patent/US6057347A/en not_active Expired - Fee Related
-
1999
- 1999-01-22 US US09/235,801 patent/US6083515A/en not_active Expired - Fee Related
- 1999-01-22 US US09/235,804 patent/US6043233A/en not_active Expired - Fee Related
- 1999-01-22 US US09/235,803 patent/US6048858A/en not_active Expired - Fee Related
-
2000
- 2000-03-03 US US09/518,541 patent/US6323234B1/en not_active Expired - Fee Related
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2001
- 2001-08-30 US US09/941,690 patent/US6482846B1/en not_active Expired - Fee Related
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2002
- 2002-10-22 US US10/277,202 patent/US6790864B2/en not_active Expired - Fee Related
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2004
- 2004-09-01 US US10/930,901 patent/US20050038029A1/en not_active Abandoned
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2006
- 2006-08-18 US US11/505,905 patent/US20060276439A1/en not_active Abandoned
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2007
- 2007-06-26 JP JP2007167646A patent/JP2007291127A/en active Pending
-
2008
- 2008-07-16 US US12/174,510 patent/US20080275010A1/en not_active Abandoned
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JPH11509519A (en) | 1999-08-24 |
EP0821589A1 (en) | 1998-02-04 |
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US20080275010A1 (en) | 2008-11-06 |
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US6057347A (en) | 2000-05-02 |
CA2218555C (en) | 2003-09-23 |
US6323234B1 (en) | 2001-11-27 |
AU710951B2 (en) | 1999-09-30 |
WO1996032946A1 (en) | 1996-10-24 |
EP0821589A4 (en) | 2002-05-15 |
US6083515A (en) | 2000-07-04 |
US20060276439A1 (en) | 2006-12-07 |
EP0821589B1 (en) | 2009-02-04 |
JP2007291127A (en) | 2007-11-08 |
AU5449396A (en) | 1996-11-07 |
US6043233A (en) | 2000-03-28 |
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