CA2219132A1 - Nucleosides with anti-hepatitis b virus activity - Google Patents
Nucleosides with anti-hepatitis b virus activityInfo
- Publication number
- CA2219132A1 CA2219132A1 CA002219132A CA2219132A CA2219132A1 CA 2219132 A1 CA2219132 A1 CA 2219132A1 CA 002219132 A CA002219132 A CA 002219132A CA 2219132 A CA2219132 A CA 2219132A CA 2219132 A1 CA2219132 A1 CA 2219132A1
- Authority
- CA
- Canada
- Prior art keywords
- hepatitis
- nucleosides
- virus activity
- hbv
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
A method for the treatment of a host, and in particular, a human, infected with HBV is provided that includes administering an HBV-treatment amount of the stabilized nucleotide of a nucleoside which exhibits anti-hepatitis B activity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2538205A CA2538205C (en) | 1995-06-07 | 1996-06-07 | Nucleosides with anti-hepatitis b virus activity |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48571695A | 1995-06-07 | 1995-06-07 | |
US08/485,716 | 1995-06-07 | ||
PCT/US1996/010026 WO1996040164A1 (en) | 1995-06-07 | 1996-06-07 | Nucleosides with anti-hepatitis b virus activity |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2538205A Division CA2538205C (en) | 1995-06-07 | 1996-06-07 | Nucleosides with anti-hepatitis b virus activity |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2219132A1 true CA2219132A1 (en) | 1996-12-19 |
CA2219132C CA2219132C (en) | 2007-03-06 |
Family
ID=23929192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002219132A Expired - Fee Related CA2219132C (en) | 1995-06-07 | 1996-06-07 | Nucleosides with anti-hepatitis b virus activity |
Country Status (11)
Country | Link |
---|---|
US (4) | US6245749B1 (en) |
EP (2) | EP1655033A1 (en) |
JP (2) | JP4413996B2 (en) |
AT (1) | ATE346651T1 (en) |
AU (1) | AU722214B2 (en) |
CA (1) | CA2219132C (en) |
DE (1) | DE69636734T2 (en) |
DK (1) | DK0831852T3 (en) |
ES (1) | ES2276404T3 (en) |
PT (1) | PT831852E (en) |
WO (1) | WO1996040164A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
CA2637774C (en) | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
PT831852E (en) | 1995-06-07 | 2007-02-28 | Uab Research Foundation | Nucleosides with anti-hepatitis b virus activity |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
EP1754710A3 (en) * | 1998-02-25 | 2007-12-19 | Emory University | 2'-Fluoroncucleosides |
EP1058686B1 (en) * | 1998-02-25 | 2006-11-02 | Emory University | 2'-fluoronucleosides |
KR100886653B1 (en) | 1998-02-25 | 2009-03-04 | 에모리 유니버시티 | 2'-Fluoronucleosides |
US6531590B1 (en) * | 1998-04-24 | 2003-03-11 | Isis Pharmaceuticals, Inc. | Processes for the synthesis of oligonucleotide compounds |
WO2000009531A2 (en) * | 1998-08-10 | 2000-02-24 | Novirio Pharmaceuticals Limited | β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B |
US6444652B1 (en) | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
US6407077B1 (en) | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
MXPA01004504A (en) | 1998-11-05 | 2005-04-19 | Centre Nat Rech Scient | Nucleosides with anti-hepatitis b virus activity. |
US6545021B1 (en) * | 1999-02-12 | 2003-04-08 | G.D. Searle & Co. | Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
US6121437A (en) * | 1999-03-16 | 2000-09-19 | Isis Pharmaceuticals, Inc. | Phosphate and thiophosphate protecting groups |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
KR101201552B1 (en) | 2000-10-18 | 2012-11-15 | 파마셋 인코포레이티드 | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
CA2826505A1 (en) | 2001-05-18 | 2002-11-28 | Rakesh Kumar | Antiviral nucleosides |
US7049303B2 (en) * | 2001-11-07 | 2006-05-23 | Medical Research Council | Inhibition of viruses |
WO2003053360A2 (en) | 2001-12-20 | 2003-07-03 | Pharmassett Ltd. | Treatment of ebv and khsv infection and associated abnormal cellular proliferation |
SE521676C2 (en) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Use of glycosaminoglycans for the prevention and treatment of pain in full-term pregnancy |
TWI244393B (en) | 2002-08-06 | 2005-12-01 | Idenix Pharmaceuticals Inc | Crystalline and amorphous forms of beta-L-2'-deoxythymidine |
AU2003278816A1 (en) | 2002-09-13 | 2004-04-30 | Idenix (Cayman) Limited | ss-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES |
CN1293884C (en) * | 2002-10-29 | 2007-01-10 | 南京长澳医药科技有限公司 | Application of 6-methocy bideoxy bideoxy guanosine in preparation of antihepatitis B medicine |
ATE442375T1 (en) * | 2002-10-31 | 2009-09-15 | Metabasis Therapeutics Inc | CYTARABINE MONOPHOSPHATE PRODRUGS |
EP1745573A4 (en) | 2003-03-20 | 2010-05-26 | Microbiol Quimica Farmaceutica | Methods of manufacture of 2 -deoxy- beta-l-nucleosides |
US20040200730A1 (en) * | 2003-04-14 | 2004-10-14 | Kyo Jibiki | Hydrometallurgical copper recovery process |
CN1812995A (en) | 2003-04-28 | 2006-08-02 | 艾登尼科斯(开曼)有限公司 | Industrially scalable nucleoside synthesis |
WO2005003374A2 (en) | 2003-06-30 | 2005-01-13 | Idenix (Cayman) Limited | SYNTHESIS OF β-L-2-DEOXY NUCLEOSIDES |
NO324263B1 (en) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Chemical compounds, their use in the treatment of cancer, and pharmaceutical compositions comprising such compounds |
GB0625283D0 (en) * | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
US7951789B2 (en) * | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
MX2012011222A (en) | 2010-04-01 | 2013-01-18 | Centre Nat Rech Scient | Compounds and pharmaceutical compositions for the treatment of viral infections. |
WO2012154321A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2013019967A1 (en) * | 2011-08-02 | 2013-02-07 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
TW201542581A (en) | 2013-09-11 | 2015-11-16 | Univ Emory | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
JP2017520545A (en) | 2014-07-02 | 2017-07-27 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Prodrug compounds and their use |
JOP20170038B1 (en) * | 2016-02-12 | 2021-08-17 | Merck Sharp & Dohme | Compounds for use for treatment and prophylaxis of HIV infection |
WO2022204014A1 (en) * | 2021-03-25 | 2022-09-29 | Per Os Biosciences, Llc. | Compositions and methods for treating coronavirus |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000137A (en) | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
US4140761A (en) | 1977-04-11 | 1979-02-20 | The United States Of America As Represented By The Department Of Health, Education & Welfare | Modification of hepatitis B virus infection in chronic carriers of hepatitis B surface antigen |
JPS5668674A (en) | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
JPS62501712A (en) | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | Anti-HTLV-3/LAV agent containing 2',3'-dideoxyinosine, 2',3'-dideoxyguanosine or 2',3'-dideoxyadenosine |
US4879277A (en) | 1985-08-26 | 1989-11-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral compositions and methods |
ATE190064T1 (en) | 1985-09-17 | 2000-03-15 | Wellcome Found | COMBINATION THERAPEUTIC NUCLEOSIDES WITH OTHER THERAPEUTICALLY EFFECTIVE COMPONENTS. |
US4916122A (en) | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
US4963533A (en) | 1986-10-24 | 1990-10-16 | Stichting Rega Vzw (Rega) | Therapeutic application of dideoxycytidinene |
AU613026B2 (en) | 1987-03-24 | 1991-07-25 | Nycomed As | 2',3' dideoxyribofuranoxide derivatives |
US5185437A (en) | 1987-04-09 | 1993-02-09 | Burroughs Wellcome Co. | Therapeutic nucleosides |
SE8701605D0 (en) | 1987-04-16 | 1987-04-16 | Astra Ab | NOVEL MEDICINAL COMPOUNDS |
AU2526188A (en) | 1987-09-22 | 1989-04-18 | Regents Of The University Of California, The | Liposomal nucleoside analogues for treating aids |
US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5270315A (en) | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
US5041449A (en) | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US5466806A (en) | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US4900828A (en) | 1988-05-12 | 1990-02-13 | Hoffmann-Laroche Inc. | Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine |
GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
SE8802687D0 (en) | 1988-07-20 | 1988-07-20 | Astra Ab | NUCLEOSIDE DERIVATIVES |
JP2788084B2 (en) | 1988-12-19 | 1998-08-20 | ザ ウエルカム フアウンデーシヨン リミテツド | Antiviral compounds |
DE69233014T2 (en) | 1989-02-08 | 2004-01-08 | Biochem Pharma Inc., Laval | METHOD FOR THE PRODUCTION OF ANTIVIRAL SUBSTITUTED 1, 3-OXATHIOLANS |
UA45942A (en) | 1989-02-08 | 2002-05-15 | Біокем Фарма, Інк. | 1,3-OXATHYOLANE, ITS DERIVATIVES, METHOD (OPTIONS) OF ITS PREPARATION AND PHARMACEUTICAL COMPOSITION |
NZ233197A (en) | 1989-04-13 | 1991-11-26 | Richard Thomas Walker | Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions |
US5059690A (en) | 1990-03-01 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Purinyl tetrahydrofurans |
US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
US5463092A (en) | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
IE904378A1 (en) | 1989-12-20 | 1991-07-03 | Abbott Lab | Analogs of oxetanyl purines and pyrimidines |
US5276151A (en) | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
EP0531452A4 (en) | 1990-05-29 | 1993-06-09 | Vical, Inc. | Synthesis of glycerol di- and triphosphate derivatives |
CA2083386C (en) | 1990-06-13 | 1999-02-16 | Arnold Glazier | Phosphorous prodrugs |
FR2663636B1 (en) | 1990-06-26 | 1992-10-09 | Centre Nat Rech Scient | PROCESS FOR THE FUNCTIONALIZATION OF AN OLIGONUCLEOTIDE. |
SE9003151D0 (en) | 1990-10-02 | 1990-10-02 | Medivir Ab | NUCLEOSIDE DERIVATIVES |
US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
DK0560794T3 (en) | 1990-11-13 | 1996-12-23 | Iaf Biochem Int | Substituted 1,3-oxathiolanes with antiviral properties |
US5587480A (en) | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
US5179104A (en) | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
US5248776A (en) | 1990-12-05 | 1993-09-28 | University Of Georgia Research Foundation, Inc. | Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides |
US5444063A (en) | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
WO1992010496A1 (en) | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES |
IL100502A (en) | 1991-01-03 | 1995-12-08 | Iaf Biochem Int | Pharmaceutical compositions containing cis-4-amino-1(hydroxymethyl-1,3-oxathiolan-5-yl)-1H-pyrimid-2-one nucleoside or its derivatives |
IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
DE69233693T2 (en) | 1991-03-06 | 2008-01-24 | Emory University | Salts and amides of (-) cis 5-fluoro-2'-deoxy-3'-thiacytidine suitable for the treatment of hepatitis B |
GB9104740D0 (en) | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
WO1992018517A1 (en) | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
GB9110874D0 (en) | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
ZA923640B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
GB9111902D0 (en) | 1991-06-03 | 1991-07-24 | Glaxo Group Ltd | Chemical compounds |
CA2112803A1 (en) * | 1991-07-12 | 1993-01-21 | Karl Y. Hostetler | Antiviral liponucleosides: treatment of hepatitis b |
US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
GB9116601D0 (en) | 1991-08-01 | 1991-09-18 | Iaf Biochem Int | 1,3-oxathiolane nucleoside analogues |
FR2685331A1 (en) | 1991-12-12 | 1993-06-25 | Centre Nat Rech Scient | PHOSPHOTRIESTERS OF DDU, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
FR2684997A1 (en) | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | DERIVATIVES OF 9- (BETA-D-XYLOFURANNOSYL) ADENINE AND 1- (BETA-D-XYLOFURANNOSYL) CYTOSINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
FR2684996A1 (en) | 1991-12-12 | 1993-06-18 | Centre Nat Rech Scient | 2 ', 3'-DIDESOXY-3'-AMINOTHYMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS. |
US5770725A (en) | 1992-05-25 | 1998-06-23 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
US5849905A (en) | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
FR2692265B1 (en) | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | BIOLOGICALLY ACTIVE COMPOUNDS OF THE PHOSPHOTRIESTER TYPE. |
WO1994005300A1 (en) | 1992-09-03 | 1994-03-17 | Biochem Pharma Inc. | Use of rapamycin in the treatment of aids |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
FR2705099B1 (en) | 1993-05-12 | 1995-08-04 | Centre Nat Rech Scient | Phosphorothioate triester oligonucleotides and process for their preparation. |
WO1994026273A1 (en) | 1993-05-12 | 1994-11-24 | Hostetler Karl Y | Acyclovir derivatives for topical use |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
EP0631783A1 (en) * | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives |
CA2637774C (en) | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
FR2709754B1 (en) | 1993-09-10 | 1995-12-01 | Centre Nat Rech Scient | Compounds 2 'or 3'-deoxy- and 2', 3'-dideoxy-beta-L-pentofuranonucleosides, preparation process and therapeutic application, in particular anti-viral. |
FR2711655A1 (en) | 1993-10-21 | 1995-05-05 | Centre Nat Rech Scient | 3'-phosphononucleoside compounds and method of preparation |
US5587362A (en) | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
US5696277A (en) | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
PT831852E (en) * | 1995-06-07 | 2007-02-28 | Uab Research Foundation | Nucleosides with anti-hepatitis b virus activity |
US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
WO2000009531A2 (en) * | 1998-08-10 | 2000-02-24 | Novirio Pharmaceuticals Limited | β-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B |
-
1996
- 1996-06-07 PT PT96919349T patent/PT831852E/en unknown
- 1996-06-07 AT AT96919349T patent/ATE346651T1/en active
- 1996-06-07 WO PCT/US1996/010026 patent/WO1996040164A1/en active IP Right Grant
- 1996-06-07 EP EP05077806A patent/EP1655033A1/en not_active Withdrawn
- 1996-06-07 DK DK96919349T patent/DK0831852T3/en active
- 1996-06-07 CA CA002219132A patent/CA2219132C/en not_active Expired - Fee Related
- 1996-06-07 EP EP96919349A patent/EP0831852B1/en not_active Expired - Lifetime
- 1996-06-07 DE DE69636734T patent/DE69636734T2/en not_active Expired - Lifetime
- 1996-06-07 ES ES96919349T patent/ES2276404T3/en not_active Expired - Lifetime
- 1996-06-07 JP JP50216397A patent/JP4413996B2/en not_active Expired - Fee Related
- 1996-06-07 AU AU61707/96A patent/AU722214B2/en not_active Ceased
-
1998
- 1998-07-09 US US09/112,878 patent/US6245749B1/en not_active Expired - Lifetime
-
2001
- 2001-06-12 US US09/879,854 patent/US7468357B2/en not_active Expired - Fee Related
-
2005
- 2005-07-12 US US11/180,964 patent/US20050277616A1/en not_active Abandoned
-
2007
- 2007-03-23 JP JP2007077327A patent/JP2007204485A/en active Pending
-
2008
- 2008-12-15 US US12/316,627 patent/US20090105185A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2219132C (en) | 2007-03-06 |
DE69636734D1 (en) | 2007-01-11 |
DE69636734T2 (en) | 2007-10-18 |
EP0831852B1 (en) | 2006-11-29 |
AU6170796A (en) | 1996-12-30 |
EP1655033A1 (en) | 2006-05-10 |
EP0831852A4 (en) | 1999-03-31 |
US20050277616A1 (en) | 2005-12-15 |
PT831852E (en) | 2007-02-28 |
US7468357B2 (en) | 2008-12-23 |
ES2276404T3 (en) | 2007-06-16 |
US20020107221A1 (en) | 2002-08-08 |
JPH11507381A (en) | 1999-06-29 |
AU722214B2 (en) | 2000-07-27 |
DK0831852T3 (en) | 2007-03-19 |
JP4413996B2 (en) | 2010-02-10 |
JP2007204485A (en) | 2007-08-16 |
EP0831852A1 (en) | 1998-04-01 |
US20090105185A1 (en) | 2009-04-23 |
US6245749B1 (en) | 2001-06-12 |
ATE346651T1 (en) | 2006-12-15 |
WO1996040164A1 (en) | 1996-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2219132A1 (en) | Nucleosides with anti-hepatitis b virus activity | |
AU6924796A (en) | 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c | |
ZA97721B (en) | Methods for retreatment of patients afflicted with hepatitis C using consensus interferon. | |
AU7954694A (en) | Nucleosides with anti-hepatitis b virus activity | |
CA2268703A1 (en) | Enantiomerically pure .beta.-d-dioxolane nucleosides with selective anti-hepatitis b virus activity | |
PL324906A1 (en) | Vaccines against viral hepatitis of c type | |
HUP9802324A3 (en) | Use of ribavirin and interferon alpha for the treatment of hepatitis c | |
EP1808434A3 (en) | Use of 5-fluoro-2'-deoxy-3'-thiacytidine fo the treatment of hepatitis B | |
EP0595436A3 (en) | Porcine respiratory and reproductive disease virus, vaccines and viral DNA. | |
PL321966A1 (en) | Vaccine against viral hepatitis of b type | |
CA2215190A1 (en) | Aryl-ester phosphoramidate derivatives of nucleosides | |
CA2197319A1 (en) | Lipid analogs for treating viral infections | |
CA2210353A1 (en) | Stabilized external guide sequences | |
AU6518890A (en) | 6-amino-1,2-benzopyrones useful for treatment of viral diseases | |
AU1905399A (en) | Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds | |
CA2143204A1 (en) | Use of Dideoxy Nucleoside Analogues in the Treatment of Viral Infections | |
EA200100494A3 (en) | Synthesis, anti-human immunodeficiency virus and anti-hepatitis b virus activities of 1,3-oxaselenolane nucleosides | |
AU2001249564A1 (en) | Method of treating hepatitis delta viral infection | |
HUP0100087A3 (en) | Nucleosides analogues, the use thereof for producing medicaments useful against retroviral infections and hepatitis b virus and the same medicaments | |
WO2000018417A3 (en) | Treatment of hepatitis b infection with thymosin alpha 1 and lamivudine | |
AU3530293A (en) | Compositions for the treatment of infection and disease caused by hepatitis B virus (HBV) | |
AU6157996A (en) | Nucleotide and amino acid sequences of hypervariable region 1 of the envelope 2 gene of hepatitis c virus | |
ZA964094B (en) | Compositions and methods for the diagnosis of and vaccination against hepatitis c virus (hcv) | |
AU6221996A (en) | Oligonucleotides specific for hepatitis c virus | |
USD376646S (en) | Syringe shield |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150608 |