CA2222103A1 - Inositolglycans having insulin-like action - Google Patents
Inositolglycans having insulin-like actionInfo
- Publication number
- CA2222103A1 CA2222103A1 CA002222103A CA2222103A CA2222103A1 CA 2222103 A1 CA2222103 A1 CA 2222103A1 CA 002222103 A CA002222103 A CA 002222103A CA 2222103 A CA2222103 A CA 2222103A CA 2222103 A1 CA2222103 A1 CA 2222103A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- inositolglycans
- insulin
- action
- r1r2n
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
Abstract
Inositolglycans having insulin-like action Compounds of the formula I
A-Z-R (I) are described, where A is the radical H - P(O)(OH) -, H - P(S)(OH) -, HO--P(S)(OH) -, HS-P(S)(OH) -, (C1-C4) - alkyl - P(O)(OH) -, (C1-C4) - alkyl -P(S)(OH)-, S(O)2(OR1) -, S(O)(OR1)-, NH2 - C(O) -, R1R2N -, R1R2N - C(O) -NH -, R1O - SO2 - NH -, (C1-C4) - alkyl - SO2 -, (C1-C4) - alkyl - S(O) - or R1 - S -, Z is 2 to 6 substituted or unsubstituted sugar radicals and R is substituted or unsubstituted inositol.
The compounds of the formula I are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes.
A-Z-R (I) are described, where A is the radical H - P(O)(OH) -, H - P(S)(OH) -, HO--P(S)(OH) -, HS-P(S)(OH) -, (C1-C4) - alkyl - P(O)(OH) -, (C1-C4) - alkyl -P(S)(OH)-, S(O)2(OR1) -, S(O)(OR1)-, NH2 - C(O) -, R1R2N -, R1R2N - C(O) -NH -, R1O - SO2 - NH -, (C1-C4) - alkyl - SO2 -, (C1-C4) - alkyl - S(O) - or R1 - S -, Z is 2 to 6 substituted or unsubstituted sugar radicals and R is substituted or unsubstituted inositol.
The compounds of the formula I are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19649350.1 | 1996-11-28 | ||
DE19649350A DE19649350A1 (en) | 1996-11-28 | 1996-11-28 | Inositol glycans with an insulin-like effect |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2222103A1 true CA2222103A1 (en) | 1998-05-28 |
CA2222103C CA2222103C (en) | 2007-08-28 |
Family
ID=7813041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002222103A Expired - Fee Related CA2222103C (en) | 1996-11-28 | 1997-11-25 | Inositolglycans having insulin-like action |
Country Status (19)
Country | Link |
---|---|
US (1) | US6004938A (en) |
EP (1) | EP0845475B1 (en) |
JP (1) | JP4299378B2 (en) |
CN (1) | CN1136224C (en) |
AR (1) | AR018246A1 (en) |
AT (1) | ATE290541T1 (en) |
AU (1) | AU728637B2 (en) |
BR (1) | BR9706041C1 (en) |
CA (1) | CA2222103C (en) |
CZ (1) | CZ294886B6 (en) |
DE (2) | DE19649350A1 (en) |
DK (1) | DK0845475T3 (en) |
ES (1) | ES2237784T3 (en) |
HK (1) | HK1008786A1 (en) |
HU (1) | HUP9702242A3 (en) |
PL (1) | PL188604B1 (en) |
PT (1) | PT845475E (en) |
RU (1) | RU2178794C2 (en) |
TR (1) | TR199701432A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7312196B2 (en) * | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
GB9814039D0 (en) * | 1998-06-29 | 1998-08-26 | Univ London | Materials and methods relating to the prevention or treatment of ischaemia-reperfusion injury |
US6953781B2 (en) | 2000-05-12 | 2005-10-11 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
US6759390B2 (en) | 2000-05-12 | 2004-07-06 | Manuel Martin-Lomas | Compounds and their uses |
US6716826B2 (en) | 2000-05-12 | 2004-04-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
EP1409498B1 (en) * | 2000-05-12 | 2008-03-26 | Rodaris Pharmaceuticals Limited | Inositol phosphoglycan derivatives and their medical uses |
US6939857B2 (en) | 2000-05-12 | 2005-09-06 | Rodaris Pharmaceuticals Limited | Compounds and their uses |
CA2433183A1 (en) * | 2000-05-12 | 2001-11-15 | Rodaris Pharmaceuticals Limited | Inositolglycans and their uses |
DE60133137D1 (en) * | 2000-05-12 | 2008-04-17 | Rodaris Pharmaceuticals Ltd | INOSITOLPHOSPHOGLYCANDERIVATE AND ITS MEDICAL USE |
GB0015627D0 (en) * | 2000-06-26 | 2000-08-16 | Rademacher Group Limited | Phosphoglycan messengers and their medical uses |
FR2828206B1 (en) * | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | USE OF LYSYL OXIDASE INHIBITORS FOR CELL CULTURE AND TISSUE ENGINEERING |
EP1503768B1 (en) * | 2002-04-29 | 2015-10-28 | NormOxys, Inc. | Inositol pyrophosphates, and use thereof |
US7943594B2 (en) * | 2002-07-10 | 2011-05-17 | Massachusetts Institute Of Technology | Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans |
CN100369610C (en) * | 2002-10-09 | 2008-02-20 | 中国药科大学 | Plant extract for preventing and treating diabetes, and preparing method and pharmaceutic use thereof |
US20070135389A1 (en) * | 2004-07-06 | 2007-06-14 | Claude Nicolau | Tumor eradication by inositol-tripyrophosphate |
US7745423B2 (en) * | 2004-07-06 | 2010-06-29 | NormOxys, Inc | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin |
US20060106000A1 (en) * | 2004-07-06 | 2006-05-18 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
FR2878850B1 (en) * | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | DERIVATIVES OF INOSITOL-1-PHOSPHATE |
EP2114414B1 (en) * | 2006-12-21 | 2013-11-06 | Trustees Of Tufts College | Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders |
EP2111226A4 (en) * | 2006-12-29 | 2010-02-10 | Normoxys Inc | Cyclitols and their derivatives and their therapeutic applications |
EP2152085A4 (en) * | 2007-05-01 | 2012-05-23 | Normoxys Inc | Erythropoietin complementation or replacement |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4446064A (en) * | 1980-12-19 | 1984-05-01 | The University Of Virginia Alumni Patents Foundation | Insulin mediator substance |
DE3326472A1 (en) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | NEW INSULIN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR TREATING THE DIABETES MELLITUS |
DE3326473A1 (en) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | PHARMACEUTICAL AGENT FOR TREATING THE DIABETES MELLITUS |
US4906468A (en) * | 1986-04-11 | 1990-03-06 | The Rockefeller University | Insulin activity messengers, their antibodies, and thereof |
YU66892A (en) * | 1991-08-20 | 1995-10-24 | Hoechst Ag. | PHOSPHOINOSYTOLGLICAN - A PEPTID WITH ACTION AS INSULIN |
EP0545198B1 (en) * | 1991-11-29 | 1999-09-15 | Hoechst Aktiengesellschaft | Peptides with insulin like activity |
JPH06293790A (en) * | 1993-04-08 | 1994-10-21 | Kyowa Hakko Kogyo Co Ltd | Physiologically active substance, inositol glucan |
US5652221A (en) * | 1994-11-07 | 1997-07-29 | The University Of Virginia Patent Foundation | Method of treating defective glucose metabolism using synthetic insulin substances |
-
1996
- 1996-11-28 DE DE19649350A patent/DE19649350A1/en not_active Withdrawn
-
1997
- 1997-11-13 DE DE59712220T patent/DE59712220D1/en not_active Expired - Fee Related
- 1997-11-13 PT PT97119835T patent/PT845475E/en unknown
- 1997-11-13 AT AT97119835T patent/ATE290541T1/en not_active IP Right Cessation
- 1997-11-13 EP EP97119835A patent/EP0845475B1/en not_active Expired - Lifetime
- 1997-11-13 DK DK97119835T patent/DK0845475T3/en active
- 1997-11-13 ES ES97119835T patent/ES2237784T3/en not_active Expired - Lifetime
- 1997-11-25 CA CA002222103A patent/CA2222103C/en not_active Expired - Fee Related
- 1997-11-26 CN CNB971229589A patent/CN1136224C/en not_active Expired - Fee Related
- 1997-11-26 HU HU9702242A patent/HUP9702242A3/en unknown
- 1997-11-26 AR ARP970105573A patent/AR018246A1/en active IP Right Grant
- 1997-11-26 AU AU45382/97A patent/AU728637B2/en not_active Ceased
- 1997-11-26 TR TR97/01432A patent/TR199701432A2/en unknown
- 1997-11-26 US US08/979,865 patent/US6004938A/en not_active Expired - Fee Related
- 1997-11-27 BR BR9706041-0A patent/BR9706041C1/en active Search and Examination
- 1997-11-27 JP JP32550897A patent/JP4299378B2/en not_active Expired - Fee Related
- 1997-11-27 CZ CZ19973775A patent/CZ294886B6/en not_active IP Right Cessation
- 1997-11-27 RU RU97120547/04A patent/RU2178794C2/en not_active IP Right Cessation
- 1997-11-28 PL PL97323407A patent/PL188604B1/en not_active IP Right Cessation
-
1998
- 1998-07-31 HK HK98109588A patent/HK1008786A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU728637B2 (en) | 2001-01-11 |
HK1008786A1 (en) | 1999-05-21 |
JP4299378B2 (en) | 2009-07-22 |
MX9709207A (en) | 1998-05-31 |
RU2178794C2 (en) | 2002-01-27 |
AR018246A1 (en) | 2001-11-14 |
DE19649350A1 (en) | 1998-06-04 |
CZ377597A3 (en) | 1998-06-17 |
HUP9702242A3 (en) | 1999-01-28 |
PL188604B1 (en) | 2005-03-31 |
CZ294886B6 (en) | 2005-04-13 |
ES2237784T3 (en) | 2005-08-01 |
PT845475E (en) | 2005-06-30 |
BR9706041C1 (en) | 2000-06-06 |
EP0845475A1 (en) | 1998-06-03 |
TR199701432A2 (en) | 1998-06-22 |
HU9702242D0 (en) | 1998-03-02 |
DE59712220D1 (en) | 2005-04-14 |
DK0845475T3 (en) | 2005-06-27 |
CN1184112A (en) | 1998-06-10 |
US6004938A (en) | 1999-12-21 |
HUP9702242A1 (en) | 1998-12-28 |
BR9706041A (en) | 1999-11-23 |
PL323407A1 (en) | 1998-06-08 |
EP0845475B1 (en) | 2005-03-09 |
JPH10158291A (en) | 1998-06-16 |
ATE290541T1 (en) | 2005-03-15 |
CA2222103C (en) | 2007-08-28 |
AU4538297A (en) | 1998-06-04 |
CN1136224C (en) | 2004-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2222103A1 (en) | Inositolglycans having insulin-like action | |
AU8163394A (en) | Treatment of diabetes by administration of myo-inositol | |
CA2103462A1 (en) | X-Ray Contrast Agent | |
CA2048110A1 (en) | Imidazopyridine derivatives and their use | |
CA2060928A1 (en) | Dental/medical composition and use | |
CA2215233A1 (en) | Terminal carboxy or tetrazole groups containing dialkyl ethers | |
CA2056971A1 (en) | Improved platy pigments | |
CA2211314A1 (en) | A process for preparing certain aza cyclohexapeptides | |
CA2205275A1 (en) | Vitamin d3 analogs | |
AU6745696A (en) | The preparation of fluorinated organic compounds | |
CA2166467A1 (en) | Sunscreen agents | |
AU584426B2 (en) | Compounds having a polymerizable acylurethane structure, and their production and use | |
CA2204478A1 (en) | Fluorinated vitamin d3 analogs | |
AU5000193A (en) | Antithrombotic treatment with calix(n)arene compounds | |
IE800477L (en) | Pyrimidine derivatives | |
CA2237897A1 (en) | 25-hydroxy-16-ene-26,27-bishomo-cholecalciferols | |
AU6752990A (en) | Combatting slime-forming microorganisms | |
CA2042535A1 (en) | Process for the preparation of intermediates useful for the synthesis of benzothiazepines | |
CA2092694A1 (en) | Use of pyridylmethylsulphinyl-1h-benzimidazole derivates in the treatment of illnesses caused by helicobacter bacteria | |
WO1997020937A3 (en) | Modification process | |
AU1032392A (en) | Multi-pressure compensation of variable displacement pump | |
CA2083361A1 (en) | Fish production | |
CA2120319A1 (en) | Pharmaceutical for the treatment of skin disorders | |
CA2123083A1 (en) | Uses of 1,1,1,3,3,3-hexafluoropropane | |
CA2034979A1 (en) | Antibiotic, deoxymulundocandin, a process for its production and its useas medicament |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |