CA2222995A1 - Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides - Google Patents

Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Info

Publication number
CA2222995A1
CA2222995A1 CA002222995A CA2222995A CA2222995A1 CA 2222995 A1 CA2222995 A1 CA 2222995A1 CA 002222995 A CA002222995 A CA 002222995A CA 2222995 A CA2222995 A CA 2222995A CA 2222995 A1 CA2222995 A1 CA 2222995A1
Authority
CA
Canada
Prior art keywords
deoxy
polypeptides
glucose
poly
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002222995A
Other languages
French (fr)
Other versions
CA2222995C (en
Inventor
Shalaby W. Shalaby
Steven A. Jackson
Francis Ignatious
Jacques-Pierre Moreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Manufacturing Ireland Ltd
Original Assignee
Biomeasure, Incorporated
Shalaby W. Shalaby
Steven A. Jackson
Francis Ignatious
Jacques-Pierre Moreau
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S .
Kinerton Limited
Ipsen Manufacturing Ireland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeasure, Incorporated, Shalaby W. Shalaby, Steven A. Jackson, Francis Ignatious, Jacques-Pierre Moreau, Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S ., Kinerton Limited, Ipsen Manufacturing Ireland Limited filed Critical Biomeasure, Incorporated
Publication of CA2222995A1 publication Critical patent/CA2222995A1/en
Application granted granted Critical
Publication of CA2222995C publication Critical patent/CA2222995C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
CA002222995A 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides Expired - Fee Related CA2222995C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/468,947 1995-06-06
US08/468,947 US5665702A (en) 1995-06-06 1995-06-06 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
PCT/US1996/007756 WO1996039160A1 (en) 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Publications (2)

Publication Number Publication Date
CA2222995A1 true CA2222995A1 (en) 1996-12-12
CA2222995C CA2222995C (en) 2005-05-10

Family

ID=23861854

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002222995A Expired - Fee Related CA2222995C (en) 1995-06-06 1996-05-24 Ionic molecular conjugates of n-acylated derivatives of poly(2-amino-2-deoxy-d-glucose) and polypeptides

Country Status (21)

Country Link
US (2) US5665702A (en)
EP (1) EP0830137B1 (en)
JP (1) JPH11508289A (en)
KR (1) KR19990022399A (en)
CN (1) CN1192152A (en)
AT (1) ATE245031T1 (en)
AU (1) AU717188B2 (en)
BR (1) BR9609031A (en)
CA (1) CA2222995C (en)
CZ (1) CZ391697A3 (en)
DE (1) DE69629114T2 (en)
DK (1) DK0830137T3 (en)
ES (1) ES2201188T3 (en)
HU (1) HUP9901627A3 (en)
NZ (1) NZ308909A (en)
PL (1) PL323735A1 (en)
PT (1) PT830137E (en)
RU (1) RU2172323C2 (en)
SI (1) SI9620090A (en)
SK (1) SK168397A3 (en)
WO (1) WO1996039160A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6479457B2 (en) * 1995-06-06 2002-11-12 Kinerton Limited Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
WO1999038536A1 (en) * 1998-01-29 1999-08-05 Poly-Med Inc. Absorbable microparticles
JP2002501907A (en) 1998-01-29 2002-01-22 キナートン・リミテッド Method for producing absorbable microparticles
HUP0104579A3 (en) 1998-12-07 2002-05-28 Univ Tulane Glp-1 analogues, pharmaceutical compositions comprising thereof and their use
JP4532618B2 (en) * 1999-02-25 2010-08-25 株式会社グライコメディクス Novel sugar primer
WO2002022154A2 (en) 2000-09-13 2002-03-21 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained drug delivery
US7122622B2 (en) * 2002-04-16 2006-10-17 Biosynthema Inc. Peptide compounds having improved binding affinity to somatostatin receptors
US7244445B2 (en) 2002-07-29 2007-07-17 Poly Med, Inc Conformable, absorbable, solid composite preforms and their use for bone tissue engineering
EP1556087A2 (en) * 2002-10-31 2005-07-27 Pfizer Products Inc. Liquid conjugates of solid pharmaceuticals
EP1583562B1 (en) 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
CA2551039C (en) 2003-12-16 2013-01-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Analogues of glp-1
CA3228910A1 (en) 2005-07-08 2007-01-18 Ipsen Pharma S.A.S Melanocortin receptor ligands
DK2433653T3 (en) 2005-07-15 2019-08-19 Angiochem Inc Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US20100256056A1 (en) 2007-09-07 2010-10-07 Zheng Xin Dong Analogues of exendin-4 and exendin-3
KR20150013339A (en) 2007-11-05 2015-02-04 입센 파마 에스.에이.에스 Use melanocortins to treat insulin sensitivity
WO2009123713A1 (en) * 2008-04-01 2009-10-08 Cornell University Organo-soluble chitosan salts and chitosan-derived biomaterials prepared thereof
MX2011000147A (en) 2008-07-04 2011-05-24 Traslational Cancer Drugs Pharma S L Methods for the treatment and diagnosis of cancer.
AU2009280021B2 (en) 2008-08-07 2012-10-04 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide (GIP) modified at N-terminal
EP2915538A3 (en) 2008-08-07 2015-10-14 Ipsen Pharma S.A.S. Truncated analogues of glucose-dependent insulinotropic polypeptide
US9074014B2 (en) 2008-08-07 2015-07-07 Ipsen Pharma S.A.S. Analogues of glucose-dependent insulinotropic polypeptide
EP2346896A4 (en) 2008-10-15 2014-06-25 Angiochem Inc Etoposide and doxorubicin conjugates for drug delivery
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
BRPI0922689A2 (en) 2008-12-05 2018-11-06 Angiochem Inc. neurotensin conjugates or neurotensin analogs and uses thereof
CN102300987A (en) 2008-12-17 2011-12-28 安吉奥开米公司 Membrane Type-1 Matrix Metalloprotein Inhibitors And Uses Thereof
EP2397152B1 (en) 2009-02-12 2014-05-28 Proyecto de Biomedicina Cima, S.L. Use of cardiotrophin- 1 for the treatment of metabolic diseases
IN2012DN00248A (en) 2009-07-02 2015-05-01 Angiochem Inc
KR101417872B1 (en) 2009-07-22 2014-07-09 입센 파마 에스.에이.에스 Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59
CN103608003B (en) * 2011-06-14 2016-05-04 益普生制药股份有限公司 Contain the slow releasing composition of melanocortin receptor ligands as active component
US9962401B2 (en) * 2011-09-27 2018-05-08 Purdue Research Foundation Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
JPS63258579A (en) * 1987-04-15 1988-10-26 Fuji Boseki Kk Production of carrier for immobilization of physiologically active substance
US5271945A (en) * 1988-07-05 1993-12-21 Takeda Chemical Industries, Ltd. Sustained release microcapsule for water soluble drug
EP0544000B1 (en) * 1990-08-17 1997-05-02 Drug Delivery System Institute, Ltd. N-acetylcarboxymethylchitosan derivative and production thereof
US5298488A (en) * 1990-10-26 1994-03-29 Fuji Photo Film Co., Ltd. CM-chitin derivatives and use thereof
IT1243390B (en) * 1990-11-22 1994-06-10 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION.
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release

Also Published As

Publication number Publication date
AU717188B2 (en) 2000-03-23
DE69629114T2 (en) 2004-04-22
PT830137E (en) 2003-10-31
KR19990022399A (en) 1999-03-25
WO1996039160A1 (en) 1996-12-12
CN1192152A (en) 1998-09-02
US5821221A (en) 1998-10-13
EP0830137B1 (en) 2003-07-16
JPH11508289A (en) 1999-07-21
PL323735A1 (en) 1998-04-14
CZ391697A3 (en) 1998-05-13
CA2222995C (en) 2005-05-10
ES2201188T3 (en) 2004-03-16
US5665702A (en) 1997-09-09
SK168397A3 (en) 1998-04-08
AU5878996A (en) 1996-12-24
ATE245031T1 (en) 2003-08-15
DE69629114D1 (en) 2003-08-21
SI9620090A (en) 1998-08-31
BR9609031A (en) 1999-12-14
HUP9901627A3 (en) 1999-11-29
DK0830137T3 (en) 2003-11-03
NZ308909A (en) 1999-06-29
EP0830137A1 (en) 1998-03-25
EP0830137A4 (en) 2002-06-26
RU2172323C2 (en) 2001-08-20
HUP9901627A1 (en) 1999-09-28

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